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1,003 results on '"Yu, Jinhua"'

213. Prediction of programmed cell death protein 1 in hepatocellular carcinoma patients using radiomics analysis with radiofrequency-based ultrasound multifeature maps.

Author

Qingmin Wang, Yi Dong, Tianlei Xiao, Shiquan Zhang, Jinhua Yu, Leyin Li, Qi Zhang, Yuanyuan Wang, Yang Xiao, Wenping Wang, Wang, Qingmin, Dong, Yi, Xiao, Tianlei, Zhang, Shiquan, Yu, Jinhua, Li, Leyin, Zhang, Qi, Wang, Yuanyuan, Xiao, Yang, and Wang, Wenping

Subjects
RADIOMICS, HEPATOCELLULAR carcinoma, FEATURE extraction, ULTRASONIC imaging, ATRIAL flutter, SUPPORT vector machines, VENTRICULAR arrhythmia
Abstract

Background: This study explored the feasibility of radiofrequency (RF)-based radiomics analysis techniques for the preoperative prediction of programmed cell death protein 1 (PD-1) in patients with hepatocellular carcinoma (HCC).Methods: The RF-based radiomics analysis method used ultrasound multifeature maps calculated from the RF signals of HCC patients, including direct energy attenuation (DEA) feature map, skewness of spectrum difference (SSD) feature map, and noncentrality parameter S of the Rician distribution (NRD) feature map. From each of the above ultrasound maps, 345 high-throughput radiomics features were extracted. Then, the useful radiomics features were selected by the sparse representation method and input into support vector machine (SVM) classifier for PD-1 prediction.Results and Conclusion: Among all the RF-based prediction models and the ultrasound grayscale comparative model, the RF-based model using all of the three ultrasound feature maps had the highest prediction accuracy (ACC) and area under the curve (AUC), which were 92.5% and 94.23%, respectively. The method proposed in this paper is effective for the meaningful feature extraction of RF signals and can effectively predict PD-1 in patients with HCC. [ABSTRACT FROM AUTHOR]

Published
2022
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219. Additional file 1 of Circular RNA SIPA1L1 promotes osteogenesis via regulating the miR-617/Smad3 axis in dental pulp stem cells

Author

Xingyun Ge, Zehan Li, Zhou, Zhou, Yibo Xia, Minxia Bian, and Yu, Jinhua

Subjects
stomatognathic system
Abstract

Additional file 1: Figure S1. Phenotype identification of DPSCs. A. Morphology of primary generation DPSCs B. Flow cytometry showed that DPSCs were negative for hematopoietic markers of CD34 and CD45. C. Flow cytometry demonstrated that DPSCs presented positive for CD29, CD73, CD90 and CD105. D. Trilineage differentiation (adipogenic, osteogenic and chondrogenic differentiations) of DPSCs analyzed by Oil red O staining, Alizarin red S staining and Alcian blue staining respectively. Immunofluorescence assay revealed that cultured DPSCs were positive for STRO-1. Scale bar = 100 μm. Figure S2. CircSIPA1L1 have no effect on DPSCs proliferation. A. Cell cycle phases in different group for proliferation index (PI=G2M+S) by flow cytometry analysis. B-D. EdU assay showed no significant difference in EdU-positive cell ratio between NC group and circSIPA1L1 group or between the Si-NC, Si-circSIPA1L1-1 and Si-circSIPA1L1-3 groups (N.S., P > 0.05). E, F. The influences of circSIPA1L1 on the cell proliferation capability was detected at 450 nm with CCK-8. CCK-8 assay showed no significant difference in cell proliferation between NC group and circSIPA1L1 group or between the Si-NC, Si-circSIPA1L1-1 and Si-circSIPA1L1-3 groups from 0 to 9 days (P>.05). CCK-8, cell counting kit-8; DPSCs, dental pulp stem cells; EdU, 5-ethynyl-20-deoxyuridine assay; PI, propidium iodide. N.S: P > 0.05.

Published
2020
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220. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases

Author

Duan Zhentao, Li Hongying, Ji Shuying, Ma Dafeng, Cui Shihong, Xi Jie, Wang Hong-wu, Ding Guifeng, Zhang Wenhao, Xu Minjuan, Yuan Wenjun, Xu Zhihong, Liao Tao, Deng Jihong, Yin Jie, Heng Mingli, Ding Yajuan, Bu Huaien, He Jing, Yang Cuirong, Cai Yan, Sun Xiaotong, Fan Yang, Sun Juying, Zhang Guanli, Ma Yuyan, Shi Tianyun, Dong Linhong, Cao Shan, Yan Qian, Zhao Ziwei, Wang Zhengling, Wang Jinhua, Li Hong, Zhou Jian, Teng Hong, Wang Zhong, Wang Ying, Jin Lin, Liu Xinghui, Yang Yimei, Zhang Meihua, Ma Fengchun, Zhao Renfeng, Lv Zhihui, Zhong Yonghong, Lu Wei, Fan Ling, Luo Xiucui, Wang Ruihua, Yu Jinhua, and Fu Fen

Subjects
medicine.medical_specialty, Nausea, business.industry, Incidence (epidemiology), General Medicine, Abdominal distension, Motherwort, 030226 pharmacology & pharmacy, Rash, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Heart rate, medicine, Chills, medicine.symptom, business, Adverse effect
Abstract

OBJECTIVE To investigate the safety profiles of Motherwort injection (MI). METHODS A multi-center, prospective and drug-derived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications. This study was based on a very large population after the injection was approved and marketed in China. All patients using the injection in participating hospitals were monitored to determine the incidence, pattern, severity and outcome of associated adverse events. RESULTS The post-marketing surveillance was performed in 10 094 female patients from April to December, 2015. The incidence of adverse drug reactions (ADRs) was 0.79‰ (8/10 094). Among the 8 patients, the reported adverse events mainly included systemic abnormalities, such as fever, chills and eyelid edema; skin and appendages disorders, such as pruritus and rash; gastrointestinal disorders, such as nausea, abdominal distension and pain; heart rate and rhythm disorders, such as palpitation and increased heart rate. All of these ADRs were mild in severity. CONCLUSION In this study the ADRs incidence rate of MI is very low, which supports that it is generally safe for use in obstetric and gynecological diseases. However, the total number of 8 ADRs recorded over a relatively short time span seems limited, and the low number of reports could not represent an absolute guarantee of safety.

Published
2018

238. Molecular subgrouping of medulloblastoma based on few-shot learning of multitasking using conventional MR images: a retrospective multicenter study

Author

Chen, Xi, primary, Fan, Zhen, additional, Li, Kay Ka-Wai, additional, Wu, Guoqing, additional, Yang, Zhong, additional, Gao, Xin, additional, Liu, Yingchao, additional, Wu, Haibo, additional, Chen, Hong, additional, Tang, Qisheng, additional, Chen, Liang, additional, Wang, Yuanyuan, additional, Mao, Ying, additional, Ng, Ho-Keung, additional, Shi, Zhifeng, additional, Yu, Jinhua, additional, and Zhou, Liangfu, additional

Published
2020
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248. Ultrasound-Based Radiomic Nomogram for Predicting Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.

Author

Tong, Yuyang, Li, Ji, Huang, Yunxia, Zhou, Jin, Liu, Tongtong, Guo, Yi, Yu, Jinhua, Zhou, Shichong, Wang, Yuanyuan, and Chang, Cai

Abstract

Rationale and Objectives: Accurate preoperative identification of lateral cervical lymph node metastasis (LNM) is important for decision-making and clinical management of patients with papillary thyroid carcinoma (PTC). The aim of this study was to develop an ultrasound (US)-based radiomic nomogram to preoperatively predict the lateral LNM in PTC patients.Methods: In this retrospective study, a total of 886 patients were enrolled and randomly divided into 2 groups. Radiomic features were extracted from the preoperative US images. A radiomic signature was constructed using the least absolute shrinkage and selection operator algorithm in the training set. Multivariate logistic regression was performed to develop the radiomic nomogram, which incorporating the radiomic signature and the selected clinical characteristics. The performance of the nomogram was assessed by its discrimination, calibration, and clinical usefulness in both the training and validation sets.Results: The radiomic signature was significantly associated with the lateral LNM in both cohorts (p< 0.001). The nomogram that consisted of radiomic signature, US-reported cervical lymph node (CLN) status, and CT-reported CLN status demonstrated good discrimination and calibration in the training and validation sets with an AUC of 0.946 and 0.914, respectively. The decision curve analysis indicated that the radiomic nomogram was worthy of clinical application.Conclusion: The radiomic nomogram proposed here has good performance for noninvasively predicting the lateral LNM and might be used to facilitate clinical decision-making and potentially improve the survival outcome in selected patients. [ABSTRACT FROM AUTHOR]

Published
2021
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249. Assessing changes in climate suitability and yields of maize and sorghum crops over Kenya in the twenty-first century.

Author

Mumo, Lucia, Yu, Jinhua, Ojara, Moses, Lukorito, Cromwel, and Kerandi, Noah

Subjects
*CLIMATE change, *SORGHUM, *TWENTY-first century, *CROPS, *CROP yields, *FOOD security, *CORN
Abstract

Climate change has and will continue to affect food security in different dimensions. This study aims at comparing current and future maize and sorghum climate suitability and yield using five state-of-art climate models in the Representative Concentration Pathways (RCP8.5) in Couple Intercomparison Project Phase 5 (CMIP5). The study considered 1970–2000 as the baseline and 2040–2060 (the 2050s) and 2061–2080 (2070s) as the projection periods. The mechanist FAO Eco-crop model and statistical crop model were used. The results show that rainfall and temperature are projected to increase by 2050s and 2070s with certain (uncertainty) in temperature (rainfall) projection. The central and western highlands are the optimum suitable zones for maize. Gradual reduction of maize suitable zone is anticipated leading to a yield loss of 10.8% (23.7%) by 2050s (2070s). The sorghum climate suitable areas are expected to increase in the future leading to a yield gain of 114% (80.7%) by 2050s (2070s) from the baseline yield. Currently, temperature creates more uncertainties in crop yield than rainfall. The findings of this research enlighten the policymakers and farmers on the probable susceptibilities of the agricultural system in future climate and the viable strategic measures to curb food insecurity over the country. [ABSTRACT FROM AUTHOR]

Published
2021
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250. Expert consensus on irrigation and intracanal medication in root canal therapy

Author

Zou, Xiaoying, Zheng, Xin, Liang, Yuhong, Zhang, Chengfei, Fan, Bing, Liang, Jingping, Ling, Junqi, Bian, Zhuan, Yu, Qing, Hou, Benxiang, Chen, Zhi, Wei, Xi, Qiu, Lihong, Chen, Wenxia, He, Wenxi, Xu, Xin, Meng, Liuyan, Zhang, Chen, Chen, Liming, Deng, Shuli, Lei, Yayan, Xie, Xiaoli, Wang, Xiaoyan, Yu, Jinhua, Zhao, Jin, Shen, Song, Zhou, Xuedong, and Yue, Lin

Abstract

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. Additionally, ambiguous clinical indications for root canal medication and non-standardized dressing protocols must be clarified. Inappropriate intracanal medication may present side effects and jeopardize the therapeutic outcomes. Indeed, clinicians have been aware of these concerns for years. Based on the current evidence of studies, this article reviews the properties of various irrigants and intracanal medicaments and elucidates their effectiveness and interactions. The evolution of different kinetic irrigation methods, their effects, limitations, the paradigm shift, current indications, and effective operational procedures regarding intracanal medication are also discussed. This expert consensus aims to establish the clinical operation guidelines for root canal irrigation and a position statement on intracanal medication, thus facilitating a better understanding of infection control, standardizing clinical practice, and ultimately improving the success of endodontic therapy.

Published
2024
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