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A highly sensitive molecular imprinted-based electrochemical sensor for resveratrol is described. Electrodeposition and electropolymerization techniques were successively used to prepare gold nanoparticles (AuNPs) and polyaniline (PANI) film on glassy carbon electrode. The as-formed porous PANI/AuNPs composite acted as a conducting network mediating electron transfer, and offered supporting matrix for anchoring the imprinted elements—polyacrylamide (PAM) that was chemically polymerized at the composite interface using acrylamide as functional monomer and resveratrol as template molecule in an amiable condition, thereby forming a molecular imprinted polymer (MIP) capable of specifically recognizing and electrochemically responding to resveratrol. The preparation conditions were carefully investigated aiming to obtain a high-performance MIP-based sensor for electrochemical sensing of resveratrol. Quantification was performed by differential pulse voltammetry in pH 4.0 phosphate buffer. The peak current was directly proportional to resveratrol concentration ranging from 1.0 μM to 200 μM, with detection limit of 87 nM. A variety of commonly coexisting ingredients such as ferulic acid, catechin, caffeic acid, vanillin, and protocatechin acid cannot produce detectable current signal in the given analytical condition, enabling the direct detection of resveratrol in wines without the requirement of sample pretreatment (e.g., chromatographic separation or solvent extraction).

Using HER2-targeted antibody drug conjugates (ADC), we tested the therapeutic efficacy, direct impact on cancer stem cells (CSCs), and potential added benefit when combined with PD-L1 blockade in immunocompetent mouse tumor models. Two murine mammary tumor models were used in this study: D2F2/E2, a cell line resulting from stable transfection of parental D2F2 murine mammary tumor cells with wild-type human HER2, and 4T1-HER2, derived from parental 4T1 by stable transduction with wild-type human HER2. We demonstrate that HER2-targeted ADC treatment induced both cellular and humoral anti-HER2 adaptive immune responses which effectively targeted both bulk tumor and cancer stem cells. We recently investigated induction of host immunity using a tumor re-challenge strategy in tumor free animals subjected to ADC or ADC + anti-PD-L1 therapy. D2F2/E2 tumor-bearing mice were treated with ADC or ADC + anti-PD-L1 to generate tumor free mice. These tumor free animals were re-challenged with the relevant tumor D2F2/E2 or irrelevant tumor WT 4T1 respectively. While all the tumor free animals re-challenged with WT 4T1 showed aggressive tumor growth, ADC-treated tumor free animals re-challenged with D2F2/E2 demonstrated significantly (p Citation Format: You Qin, Hannah E. Dobson, Frank I. Comer, Alfred E. Chang, Max S. Wicha, Qiao Li. Specific anti-HER2 host immunity conferred by HER2-targeted antibody drug conjugate therapy and checkpoint blockade [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 514.

Ethnopharmacological relevance With the spread of Coronavirus Disease 2019 (COVID-19), combination with traditional Chinese medicine (TCM) has been widely used as a prevention and therapy strategy in China. Xin guan No.1 (XG-1) prescription is a preventive formula recommended by the Hunan Provincial Administration of TCM to prevent the pandemic of COVID-19. Aim of the study To explore the potential preventive mechanisms of XG-1 against COVID-19 in the combination of network pharmacology approach, single-cell RNA expression profiling analysis, molecular docking and retrospective study. Materials and Methods Encyclopedia of Traditional Chinese Medicine (ETCM) database was used to determine the meridian tropism, active components and target genes of XG-1. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis were conducted by R Cluster Profiler package (3.14.3). Single cell RNA sequencing(scRNA-seq) data of human lung (GSE122960) was downloaded from Gene Expression Omnibus (GEO) database and analyzed by R Seurat package (3.1.2). Cytoscape (3.7.2) was used to construct the interaction network. The main ingredients in XG-1 were identified by HPLC- Q-TOF -MS and used for molecular docking with COVID-19 3CL hydrolytic enzyme and angiotensin converting enzyme II (ACE2). A retrospective study of 47 close contact participants from Dongtang Community of Hunan Province was conducted to evaluated the preventive effect of XG-1. Results According to the network pharmacology analysis, XG-1 formula was closely related to lung-, spleen- and stomach-meridians and include a total of 206 active components and 853 target genes. GO and KEGG pathway enrichment revealed that XG-1 mainly regulated cellular amino acid metabolism process and neuroactive ligand-receptors interaction. The scRNA-seq profiling showed that angiotensin converting enzyme 2 (ACE2) was principally expressed in alveolar type 2 epithelial cells (AT2). 153 genes were up-regulated in AT2 cells expressing ACE2 and 12 genes were obtained by intersecting with XG-1 target genes, of which 3 were related to immunity. Five main chemical ingredients were detected in XG-1 sample by HPLC-Q-TOF-MS. The molecular docking showed that Rutin, Liquiritin and Astragaloside Ⅳ had a good affinity with COVID-19 3CL hydrolytic enzyme and ACE2. Compared with participants who didn’t take XG-1, preventive treatment with XG-1gradules resulted in a significant lower rate of testing positive for SARS-CoV-2 nucleic acid (p, Graphical abstract Image 1

We previously tested HER2-targeted antibody drug conjugates (ADC) in immunocompromised (SCID) mice, precluding evaluation of host immunity, impact on cancer stem cells (CSCs), and potential benefit when combined with PD-L1 blockade. In this study, we tested HER2-targeted ADC in two immunocompetent mouse tumor models. HER2-targeted ADC specifically inhibited the growth of HER2-expressing tumors, prolonged animal survival, and reduced HER2(+) and PD-L1(+) cells. ADC plus anti-PD-L1 antibody augmented therapeutic efficacy, modulated immune gene signatures, increased the number and function of CD3(+) and CD19(+) tumor-infiltrating lymphocytes (TILs), induced tumor antigen specific immunological memory, stimulated B cell activation, differentiation, and IgG1 production both systemically and in the tumor microenvironment. In addition, ADC therapy modulated T cell subsets and their activation in TILs. Furthermore, HER2-targeted ADC reduced the number and tumorigenicity of ALDH(hi) CSCs. This study demonstrates that HER2-targeted ADC effectively targets ALDH(hi) CSCs and this effect is augmented by co-administration of anti-PD-L1 antibody.

In the recent paper [1], we carry out the numerical calculations for back-to-back dihadron and hadron-jet angular correlations within the Sudakov resummation framework. This framework allows us to compute transverse momentum broadening and away-side angular correlations in pp collisions for the first time and use it as the baseline to study the medium effects in AA collisions. It paves the way for the quantitative study of jet-medium interaction and the transport properties of QGP. This proceeding is mainly a brief summary of that paper.

A brief review of some of recent progresses on theoretical and phenomenological jet quenching studies in heavy-ion collisions is provided, with particular focus on the nuclear modification of jet rate, shape and structure.

We study the evolution of full jet shower in quark-gluon plasma via solving a set of coupled differential transport equations for the three-dimensional momentum distributions of quarks and gluons contained in the full jets. The evolution equations include all partonic splitting processes as well as the collisional energy loss and transverse momentum broadening for both the leading and radiated partons of the full jets. Combining with realistic hydrodynamic simulation for the space-time evolution of the fireball created in Pb+Pb collisions at 2.76A TeV, we calculate the nuclear modification of single inclusive full jet spectra, the momentum imbalance of photon-jet and dijet pairs, and jet shape function (at partonic level). The roles of various jet-medium interaction mechanisms on the modification of full jet energy and internal structure are studied.

We study the nuclear modification of full jet structure in relativistic heavy-ion collisions, with the inclusion of the effect of the medium response. The evolution of full jet shower is described by a set of transport equations, and the space-time evolution of quark-gluon plasma is simulated by solving relativistic hydrodynamic equations coupled with the energy and momentum depositions by jets as the source terms. We study the effect of medium response to full jet shower and present how jet-induced flow contributes to the full jet structure in PbPb collisions at the LHC.

We establish a linear Boltzmann transport (LBT) model coupled to hydrodynamical background to study hard parton evolution in heavy-ion collisions. Both elastic and inelastic scatterings are included in our calculations; and heavy and light flavor partons are treated on the same footing. Within this LBT model, we provide good descriptions of heavy and light hadron suppression from RHIC to the LHC energies. Possible solutions to the R AA vs. v 2 puzzle are discussed.

Visible-light-driven bismuth vanadate (BiVO4) photocatalysts were prepared by the co-precipitation method. The BiVO4 samples were characterized using X-ray diffraction, UV–visible diffuse reflectance, electrochemical impedance spectroscopy (EIS), photocurrent, and as well as electron microscopy (SEM, TEM). The photocatalytic activity of the as-prepared BiVO4 samples was tested through the photocatalytic oxidation of glyphosate under visible light irradiation. The dark yellow amorphous BiVO4 powder was prepared by the HAc method after drying at 70 °C, but the bright yellow monoclinic BiVO4 was obtained after keeping at room temperature in the air for several days. The dependence of the room temperature crystallization on moisture can explain the low crystallization temperature found in this work. The BiVO4 sample calcined at 400 °C by the HAc method showed the highest photocatalytic activity for glyphosate degradation under visible light irradiation because of its high charge separation efficiency proven by EIS and photocurrent.

Polygonatum (Asparagaceae) is a medicinal and food plant that is naturally distributed in most of countries throughout the temperate Northern Hemisphere. Here we report on the complete chloroplast ...

Lilium pumilum DC. is a useful plant species not only for its showy flowers but also for its edible and medicinal values. Here we report on the complete chloroplast genome sequence of L. pumilum. T...

Lilium brownii F.E.Brown var. viridulum Baker is a medicinal and food plant that is widely distributed in northern and eastern Asia. Here, we report on the complete chloroplast genome sequence of L. brownii var. viridulum. The chloroplast genome is 152,665 bp in size and includes two inverted repeat regions of 53,052 bp, which is separated by a large single-copy region of 82,085 bp and a small single-copy region of 17,528 bp. A total of 131 genes were predicted, including 38 tRNA, 8 rRNA, and 85 protein-coding genes. Phylogenetic analysis placed L. brownii var. viridulum under the family Liliaceae.

We investigate the decorrelation of 2nd and 3rd order anisotropic flow for charged particles in two different pseudo rapidity ( η ) windows by varying the pseudo rapidity gap, in an event-by-event (3+1)D ideal hydrodynamic model, with fluctuating initial conditions from A Multi-Phase Transport (AMPT) model. We visualize the parton distribution at initial state for Pb+Pb collisions at LHC and Au+Au collisions at RHIC, and demonstrate the longitudinal fluctuations originating from the asymmetry between forward and backward going participants, the fluctuations of the string length and the fluctuations due to finite number of partons at different beam energies. The decorrelation of anisotropic flow of final hadrons with large η gaps is found to originate from the spatial decorrelation along the longitudinal direction in the AMPT initial conditions through hydrodynamic evolution. The agreement between our results and recent CMS data in most centralities suggests that the string-like mechanism of initial parton production in AMPT model captures the initial longitudinal fluctuation that is responsible for the measured decorrelation of anisotropic flow in Pb+Pb collisions at LHC. Our predictions for Au+Au collisions at the highest RHIC energy show stronger longitudinal decorrelation than at LHC, indicating larger longitudinal fluctuations at lower beam energies.

We study the medium modification of heavy quarks produced in heavy-ion collisions. The evolution of heavy quarks inside the QGP is described using a modified Langevin framework that simultaneously incorporates their collisional and radiative energy loss. Within this framework, we provide good descriptions of the heavy meson suppression and predictions for the two-particle correlation functions of heavy meson pairs.

Objective: To analyze the effect of Danshen injection on PILON fracture healing as well as BMP-7, TGF-β1 and bFGF expression. Methods: A total of 78 patients with PILON fracture were randomly divided into observation group and control group (n=39), control group received routine open reduction and internal fixation, observation group received Danshen injection after operation, and then differences in mortise shape under X ray and ankle function parameters as well as serum levels of bone metabolism markers and osteogenesis-related factors were compared between two groups of patients after operation. Results: Mortise width, depth, coronal angle and sagittal angle values of observation group after operation were lower than those of control group (P

We study the medium-induced gluon emission process experienced by a hard jet parton propagating through the dense nuclear matter in the framework of deep inelastic scattering off a large nucleus. We work beyond the collinear rescattering expansion and the soft gluon emission limit, and derive a closed formula for the medium-induced single gluon emission spectrum from a heavy or light quark jet interacting with the dense nuclear medium via transverse and longitudinal scatterings. Without performing the collinear rescattering expansion, the medium-induced gluon emission spectrum is controlled by the full distribution of the differential elastic scattering rates between the propagating partons and the medium constituents. We further show that if one utilizes heavy static scattering centers for the traversed nuclear matter and takes the soft gluon emission limit, our result can reduce to the first order in opacity Djordjevic-Gyulassy-Levai-Vitev formula., 21 pages, 14 figures

Ethnopharmacological relevance Chaihu-Longgu-Muli decoction (CLMD) is a well-known ancient formula in traditional Chinese medicine (TCM) to relieve disorder, clear away heat, tranquilize the mind and allay excitement. It has been used for the therapy of neuropsychiatric disorders such as epilepsy, dementia, insomnia, anxiety, and depression for several centuries in China. Aim of the study This paper is based on the assumption that the mechanism by which CLMD relieves epileptic symptoms in rats is associated with improving autophagy. Several experimental methods are designed to testify the hypothesis. Materials and methods The lithium-pilocarpine-induced epilepsy model was established in rats. The seizure frequency was recorded. Morphology and number of autophagosomes in hippocampal dentate gyrus was detected with a transmission electron microscope (TEM). Expression of Beclin-1, microtubule-associated proteins 1A/1B light chain 3 (LC3), and mammalian target of rapamycin (mTOR) in dentate gyrus was measured by immunofluorescence assay, quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western-blotting. Results CLMD could significantly relieve the seizure frequency and improve autophagy in hippocampal dentate gyrus. Meanwhile, the level of Beclin-1 and LC3B decreased significantly, while mTOR increased remarkably after medical intervention. Conclusions CLMD could improve autophagy in hippocampal dentate gyrus due to epilepsy, especially at high dose. The mechanism may be related to upregulated expression of mTOR and downregulated expression of Beclin-1 and LC3B.

Quinoa, a food crop native to South America, is now gaining much attention in China. Quinoa was introduced to China in the 1960s; however, it was only distributed in scattered districts until 2008. The foundation of the Quinoa Committee of the Crop Science Society of China (QCCSSC) in 2015 has promoted the combination of policy-makers, researchers, manufacturers, and farmers related to quinoa. In 2018, the harvest area of quinoa in China increased to nearly 12,000 ha, with a total production of 20,000 tons distributed in 24 provinces. Through the collaboration of enterprise and research institutes, quinoa cultivation techniques were integrated into different eco-regions, and a series of stabilized breeding materials was gained. Additionally, 14 varieties were certified by provincial or municipal cultivar registration committees. Quinoa products, such as noodles, liquor, and yogurt, were developed based on nutritional and technological research. Thanks to the promulgation of the first Chinese industrial standard for quinoa, quinoa products are now available both in online shops and offline supermarkets. Above all, China is undergoing an adjustment of sustainable agricultural policy and increasing demands for more nutritional and diversified foods, demonstrating a great prospect for quinoa. Resumen La quinua, un cultivo alimenticio originario de América del Sur, ahora está ganando mucha atención en China. La quinua se introdujo en China en la década de 1960; sin embargo, solo se distribuyó en distritos dispersos hasta 2008. La fundación del Comité de Quinua de la Sociedad de Ciencia de Cultivos de China (QCCSSC) en 2015 ha promovido la combinación de creadores de políticas, investigadores, fabricantes y agricultores relacionados con la quinua. En 2018, el área de cosecha de la quinua en China aumentó a casi 12,000 ha, con una producción total de 20,000 toneladas distribuidas en 24 provincias. A través de la colaboración de empresas e institutos de investigación, las técnicas de cultivo de quinua se integraron en diferentes ecorregiones y se obtuvo una serie de materiales de reproducción estabilizados. Adicionalmente, 14 variedades fueron certificadas por comités de registro de cultivares provinciales o municipales. Los productos de la quinua, como los fideos, el licor y el yogur, se desarrollaron a partir de investigaciones nutricionales y tecnológicas. Gracias a la promulgación del primer estándar industrial chino para la quinua, los productos de quinua ahora están disponibles tanto en las tiendas en línea como en los supermercados fuera de línea. Por encima de todo, China está experimentando un ajuste de la política agrícola sostenible y la creciente demanda de alimentos más nutritivos y diversificados, lo que demuestra una gran perspectiva para la quinua.

Background Patients with head and neck cancer (HNC) who are receiving radiotherapy commonly face detrimental complications, including oral issues. However, oral symptoms are not well understood given the lack of available specific assessment instruments. The Vanderbilt Head and Neck Symptom Survey version (VHNSS) 2.0 is an instrument specifically developed to identify oral symptoms in HNC patients receiving radiotherapy in the United States. Objective To perform the translation and cross-cultural adaptation of the original English version of VHNSS 2.0 into a Chinese version (Mainland China). Methods The translation and cultural adaptation process involved translation by independent translators, construction of a consensus version, back translation into the original English version, analysis by the expert committee and a pretest. The pretest was administered to 90 patients with HNC to assess the feasibility and practicality of the tool. Results The final Chinese version approved by the expert committee was well understood by all participants in the study. The instrument had satisfactory content validity, with indexes of 0.83 for semantic and idiomatic equivalence, 0.90 for cultural equivalence, and 0.91 for conceptual equivalence. Furthermore, this version had good internal consistency, with Cronbach's alpha coefficients ranging from 0.74 to 0.95. Conclusion The Chinese version of VHNSS 2.0 was translated and cross-culturally adapted for use in China. This translation is a feasible instrument to assess oral health-related quality of life in HNC patients undergoing radiotherapy and will be useful for symptom management by clinicians and researchers in China.

Using the dilute-dense factorization in the color glass condensate framework, we investigate the azimuthal angular correlation between a heavy quarkonium and a charged light hadron in proton-nucleus collisions. We extract the second harmonic v2, commonly known as the elliptic flow, with the light hadron as the reference. This particular azimuthal angular correlation between a heavy meson and a light hadron was first measured at the LHC recently. The experimental results indicate that the elliptic flows for heavy flavor mesons (J/ψ and D0) are almost as large as those for light hadrons. Our calculation demonstrates that this result can be naturally interpreted as an initial state effect due to the interaction between the incoming partons from the proton and the dense gluons inside the target nucleus. Since the heavy quarkonium v2 exhibits a weak mass dependence according to our calculation, we predict that the heavy quarkonium ϒ should have a similar elliptic flow as compared to that of the J/ψ, which can be tested in future measurements.

Herpes simplex encephalitis (HSE) is the most common infectious disease of the central nervous system worldwide. However, the pathogenesis of HSE is not clear. Research has shown that the immune response mediated by the toll-like receptor 3 (TLR3) signaling pathway is essential to protect the central nervous system against herpes simplex virus (HSV) infection. However, an excessive immune response may cause tissue damage accompanied by pathological changes. The aim of this study was to explore the molecular mechanism via which corilagin controls HSE through the TLR3 signaling pathway in vitro and in vivo. Cells and mice were pre-treated with polyriboinosinic polyribocytidylic acid [poly(I:C)] or HSV type 1, and then treated with corilagin. After treatment, the mRNA and protein levels of TLR3, TLR-like receptor-associated interferon factor (TRIF), tumor necrosis factor (TNF) receptor type 1-associated DEATH domain protein (TRADD), TNF receptor-associated factor (TRAF) 3 and 6, nuclear factor-kappa-B (NF-κB) essential modulator (NEMO), P38, and interferon regulatory factor 3 (IRF3) were decreased. Interleukin-6 (IL-6), TNF-α, and type 1 interferon-β were also decreased. When TLR3 expression was silenced or increased, corilagin still inhibited the expression of TLR3 and its downstream mediators. Hematoxylin-eosin (HE) staining and immunohistochemical examinations of mouse brain tissues revealed that corilagin lessened the degree of brain inflammation. Altogether, these results suggest that corilagin may regulate the immune response in HSE and relieve inflammatory injury by interfering with the TLR3 signaling pathway.

The authors have retracted this article [1] because of numerous errors in the figures. Specifically

Traditional Chinese medicine formula granules (TCMFGs), an advanced dosage form of traditional Chinese medicine, are entering the market on a large scale. However, little attention has been paid to the simultaneous efficacy assessment and quality control of this advanced dosage form. In this study, a comprehensive comparison of the pharmacological activity and chemical consistency of TCMFGs from different manufacturers was performed. Ge-Gen decoction (GGD) samples were used as the target TCMFG. The in vitro anti-inflammatory effects among different types of GGDs indicate that all of them showed different abilities to reduce the lipopolysaccharide-activated production of nitric oxide, interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α. The results from a dimethylbenzene-induced inflammation model in mice indicated that the nine samples in this study showed significant in vivo anti-inflammatory effects. Qualitative and quantitative analyses were performed by multiwavelength ultra-high-performance liquid chromatography with diode array detection and electrospray ionization with quadrupole time-of-flight-tandem mass spectrometry. To visually interpret the differences in the chemical materials, a scatter plot analysis was performed. According to the scatter plot analysis, nine compounds were evaluated as important contributors to the differences. This is the first report of TCMFGs on the basis of the spectrum-effect consistency.

We study the nuclear modification of the splitting function of groomed jets in relativistic heavy-ion collisions within the higher twist formalism. With the assumption of coherent energy loss of the two prongs, we find a non-monotonic dependence on jet energy for the nuclear modification of the jet splitting function, and provide a simultaneous description of the experimental data at RHIC and the LHC. On the contrary, the same experiment data cannot be explained within the picture of independent energy loss of the two prongs within the groomed jet.

We study the suppressions of high transverse momentum single hadron and dihadron productions in high-energy heavy-ion collisions based on the framework of a next-to-leading-order perturbative QCD parton model combined with the higher-twist energy loss formalism. Our model can provide a consistent description for the nuclear modification factors of single hadron and dihadron productions in central and non-central nucleus–nucleus collisions at RHIC and the LHC energies. We quantitatively extract the value of jet quenching parameter $$\hat{q}$$ via a global $$\chi ^2$$ analysis, and obtain $${\hat{q}}/{T^3} = 4.1$$ –4.4 at $$T = 378$$ MeV at RHIC and $${\hat{q}}/{T^3} = 2.6$$ –3.3 at $$T = 486$$ MeV at the LHC, which are consistent with the results from JET Collaboration. We also provide the predictions for the nuclear modification factors of dihadron productions in Pb + Pb collisions at $$\sqrt{s_\mathrm{{NN}}}$$ = 5.02 TeV and in Xe + Xe collisions at $$\sqrt{s_\mathrm{{NN}}}$$ = 5.44 TeV.

The High Twist approach has been used to calculate parton energy loss and the medium modified fragmentation function due to multiple parton scattering. We revisit this problem for the deeply inelastic scattering (DIS) process with a Generalized High Twist approach. In this approach, the differential radiated gluon number distribution can be expressed in terms of the unintegrated gluon distribution function, or the transverse momentum dependent jet transport coefficient. The radiated gluon spectrum can be calculated without soft gluon and static medium approximation. In these limits, one can recover the GLV result in first order opacity approximation.

International audience; In the recent two papers, we establish the Sudakov resummation improved perturbative QCD calculation approach to quantitatively study the dijet and photon-jet transverse momentum imbalances in high energy proton-proton collisions. The hard splittings have been taken into account by the next-to-leading order calculation in perturbative QCD, while, the soft gluon radiations (parton shower) have been taken care of by the Sudakov resummation. Based on BDMPS energy loss approach, we calculate the transverse momentum imbalances in the nucleus-nucleus collisions as well and extract the value of $\hat q$. This proceeding is a summary of these two papers.

With our coupled jet-fluid model, we study the nuclear modifications of full jets and jet structures for single inclusive jet and $\gamma$-jet events in relativistic heavy-ion collisions. The evolution of full jet showers is studied via a set of coupled transport equations including the effects of collisional energy loss, transverse momentum broadening and medium-induced splitting. The dynamics of the jet energy and momentum deposited into the medium is described by hydrodynamic equations with source terms. Our detailed analysis indicates that collisional absorption (energy loss) tends to narrow the jet shape function while transverse momentum kicks and medium-induced radiations broaden the jet transverse profile. Also, jet-induced flow plays a significant contribution to jet shape function and dominates at large angles away from the jet axis. The final nuclear modification pattern for the jet shape function is a combined effect from various jet-medium interaction mechanisms. Our detailed studies for single inclusive jets and $\gamma$-jets for various kinematics indicate that the nuclear modification of jet shape has strong dependence on jet energy and collision energy, and weak dependence on jet flavor (quark or gluon)., Comment: 5 pages, 3 figures, Proceedings of Hard Probes 2018, 30 September-5 October, Aix-Les-Bains, France

Heavy quarks serve as ideal probes of the QGP properties produced in energetic nuclear collisions, and provide a unique opportunity to study the mass effects on parton energy loss. We develop a multi-stage approach for heavy quark evolution inside the QGP, in which heavy quarks first undergo a rare-scattering multiple-emission evolution at momenta large compared to their mass (sensitive only to the transverse diffusion coefficient $\hat{q}$ ), and then evolve through a single-scattering induced emission (Gunion-Bertsch) stage at momenta comparable to their mass [sensitive to not only $\hat{q}$, but also the longitudinal drag $\hat{e}$ and diffusion $\hat{e}_2$ coefficients]. This multi-stage approach is coupled to a (2+1)-D viscous hydrodynamic model for a quantitative investigation of charm vs. beauty quark energy loss inside the QGP. Based on this approach, we find that drag induced radiation has a considerable impact on the energy loss of intermediate $p_T$ massive beauty quarks. This effect increases the suppression of B mesons and narrows the difference between the $R_{AA}$ of B and D mesons. Our results are consistent with the experimental data at the LHC and contribute to a more quantitative understanding of the transverse momentum dependence of the mass hierarchy of parton energy loss inside the QGP., Comment: 5 pages, 2 figures, Latex, Proceedings of the International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions, 30 September - 5 October 2018, Aix-Les-Bains, Savoie, France

With our coupled jet-fluid model, we study the nuclear modifications of full jets and jet structures for single inclusive jets and $\gamma$-jets in Pb+Pb collisions at $5.02$~ATeV and $2.76$~ATeV. The in-medium evolution of full jet shower is described by a set of coupled transport equations including the effects of collisional energy loss, transverse momentum broadening and medium-induced splitting process. The dynamical evolution of bulk medium is simulated by solving relativistic hydrodynamic equation with source term which accounts for the energy and momentum deposited by hard jet shower to soft medium. Our study demonstrates that the hydrodynamic medium response to jet propagation significantly enhances the broadening of jet shape at large angles and is essential for the cone-size dependence of jet energy loss and nuclear modification factor of inclusive jet production. It is also found that the nuclear modification pattern of jet shape is sensitive to jet energy but has weak dependence on the flavor of the parton that initiates the jet. Our result can naturally explain the different nuclear modification patterns of jet shape functions for single inclusive jet and $\gamma$-jet events as observed by the CMS Collaboration, and can be tested in the future by measuring the jet shape function over a wider range of jet energies in heavy-ion collisions., Comment: 10 pages, 8 figures. To be published in PLB

Ursolic acid (UA) is a biologically active compound, commonly used in traditional Chinese medicine (TCM). It has been reported to exhibit strong anticancer properties against a variety of cancers. Our previous studies showed that UA promoted apoptosis in colorectal cancer (CRC) cells and inhibited cellular proliferation and angiogenesis. However, the effect and underlying molecular mechanism of UA in CRC progression remain unclear. In the present study, the role of UA in suppressing the migration and invasion of human colon cancer HCT116 and HCT-8 cells was investigated, using Transwell assays. In addition, to evaluate whether the anticancer properties of UA were mediated by the regulation of a double-negative feedback loop consisting of the transforming growth factor-β1 (TGF-β1)/zinc finger E-box-binding homeobox (ZEB1) pathway and microRNA (miR)-200a/b/c, reverse transcription-quantitative PCR and western blot analysis were performed. The results indicated that UA treatment significantly suppressed cellular growth, migration and invasion in HCT116 and HCT-8 cells in a dose-dependent manner. Furthermore, following UA treatment, several crucial mediators of the TGF-β1 signaling pathway, including TGF-β1, phosphorylated (p)-Smad2/3, p-focal adhesion kinase and ZEB1, were significantly downregulated in the HCT116 and HCT-8 cell lines compared with the control group. Furthermore, the ratio of N-cadherin/E-cadherin, two proteins directly downstream of the TGF-β1 signaling pathway, was found to be downregulated in UA treated CRC cells. Finally, UA significantly upregulated miR200a/b/c, with miR-200c exhibiting the highest increase in expression levels following UA treatment. Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-β1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer.

It is widely acknowledged that heavy flavor probes are sensitive to the properties of the quark-gluon plasma and are often considered an important tool for the plasma tomography studies. Forward rapidity observables can provide further insight on the dynamics of the medium due to the interplay between the medium size and the differences in the production spectra of heavy quark probes. In this proceedings we present the nuclear modification factor $R_\text{AA}$'s for B and D mesons, as well as heavy flavor leptons, in the rapidity range $-4.0 < y < 4.0$ obtained from relativistic Langevin equation with gluon radiation coupled with a (3+1)-dimensional viscous hydrodynamics medium background. We present comparison with experimental data at mid-rapidity as well as predictions for different rapidity ranges., 4 pages, 4 figures, contribution to the proceedings of Quark Matter - XXVIII international conference on ultrarelativistic heavy-ion collisions (Wuhan, China, 4-9 November, 2019)