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202. Frequent expression of MAGE1 tumor antigens in bronchial epithelium of smokers without lung cancer

Author

J. Jack Lee, Li Mao, Ashutosh Pathak, Hongli Tang, Jonathan M. Kurie, You H. Fan, Diane D. Liu, Manisha Bhutani, Waun Ki Hong, and Rodolfo C. Morice

Subjects
Oncology, endocrine system, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, medicine.disease_cause, Malignant transformation, Immunology and Microbiology (miscellaneous), Internal medicine, medicine, Lung cancer, neoplasms, Melanoma-associated antigen, Lung, Oncogene, business.industry, Cancer, Articles, General Medicine, Immunotherapy, respiratory system, medicine.disease, respiratory tract diseases, medicine.anatomical_structure, Immunology, Carcinogenesis, business
Abstract

Melanoma antigens (MAGE) are frequently expressed in lung cancer and are promising targets of anticancer immunotherapy. Our preliminary data suggested that MAGE may be expressed during early lung carcinogenesis, raising the possibility of targeting MAGE as a lung cancer prevention strategy. The purpose of this study was to investigate MAGE activation patterns in the airways of chronic smokers without lung cancer. MAGE-A1, -A3 and -B2 gene expression was determined in bronchial brush cells from chronic former smokers without lung cancer by reverse transcription-PCR (RT-PCR). The results were correlated with clinical parameters. The 123 subjects had a median age of 57 years, a median of 40 pack-years smoking history, and had quit smoking for at least one year prior to enrollment. Among the subjects, 31 (25%), 38 (31%), and 46 (37%) had detectable MAGE-A1, -A3 and -B2 expression, respectively, in their bronchial brush samples. Expression of MAGE-A1 and -B2 positively correlated with pack-years smoking history (P=0.03 and 0.03, respectively). The frequency of expression did not decrease despite a prolonged smoking cessation period. In conclusion, MAGE-A1, -A3 and -B2 genes are frequently expressed in the bronchial epithelial cells of chronic smokers without lung cancer, suggesting that chronic exposure to cigarette smoke activates these genes even before the malignant transformation of bronchial cells in susceptible individuals. Once activated, the expression persists despite long-term smoking cessation. These data support the targeting of MAGE as a novel lung cancer prevention strategy.

Published
2010

209. Comparison of key fine-line BEOL metallization schemes for beyond 7 nm node

Author

Nogami, T., primary, Zhang, X., additional, Kelly, J., additional, Briggs, B., additional, You, H., additional, Patlolla, R., additional, Huang, H., additional, McLaughlin, P., additional, Lee, J., additional, Shobha, H., additional, Nguyen, S., additional, DeVries, S., additional, Demarest, J., additional, Lian, G., additional, Li, J., additional, Maniscalco, J., additional, Bhosale, P., additional, Lin, X., additional, Peethala, B., additional, Lanzillo, N., additional, Kane, T., additional, Yang, C. C., additional, Motoyama, K., additional, Sil, D., additional, Spooner, T., additional, Canaperi, D., additional, Standaert, T., additional, Lian, S., additional, Grill, A., additional, Edelstein, D., additional, and Paruchuri, V., additional

Published
2017
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213. The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)

Author

Matz, Melissa, primary, Coleman, Michel P, additional, Sant, Milena, additional, Chirlaque, Maria Dolores, additional, Visser, Otto, additional, Gore, Martin, additional, Allemani, Claudia, additional, Bouzbid, S., additional, Hamdi-Chérif, M., additional, Zaidi, Z., additional, Bah, E., additional, Swaminathan, R., additional, Nortje, S.H., additional, Stefan, D.C., additional, El Mistiri, M.M., additional, Bayo, S., additional, Malle, B., additional, Manraj, S.S., additional, Sewpaul-Sungkur, R., additional, Fabowale, A., additional, Ogunbiyi, O.J., additional, Bradshaw, D., additional, Somdyala, N.I.M., additional, Abdel-Rahman, M., additional, Jaidane, L., additional, Mokni, M., additional, Kumcher, I., additional, Moreno, F., additional, González, M.S., additional, Laura, E.A., additional, Espinola, S.B., additional, Calabrano, G.H., additional, Carballo Quintero, B., additional, Fita, R., additional, Garcilazo, D.A., additional, Giacciani, P.L., additional, Diumenjo, M.C., additional, Laspada, W.D., additional, Green, M.A., additional, Lanza, M.F., additional, Ibañez, S.G., additional, Lima, C.A., additional, Lobo de Oliveira, E., additional, Daniel, C., additional, Scandiuzzi, C., additional, De Souza, P.C.F., additional, Melo, C.D., additional, Del Pino, K., additional, Laporte, C., additional, Curado, M.P., additional, de Oliveira, J.C., additional, Veneziano, C.L.A., additional, Veneziano, D.B., additional, Alexandre, T.S., additional, Verdugo, A.S., additional, Azevedo e Silva, G., additional, Galaz, J.C., additional, Moya, J.A., additional, Herrmann, D.A., additional, Vargas, S., additional, Herrera, V.M., additional, Uribe, C.J., additional, Bravo, L.E., additional, Arias-Ortiz, N.E., additional, Jurado, D.M., additional, Yépez, M.C., additional, Galán, Y.H., additional, Torres, P., additional, Martínez-Reyes, F., additional, Pérez-Meza, M.L., additional, Jaramillo, L., additional, Quinto, R., additional, Cueva, P., additional, Yépez, J.G., additional, Torres-Cintrón, C.R., additional, Tortolero-Luna, G., additional, Alonso, R., additional, Barrios, E., additional, Nikiforuk, C., additional, Shack, L., additional, Coldman, A.J., additional, Woods, R.R., additional, Noonan, G., additional, Turner, D., additional, Kumar, E., additional, Zhang, B., additional, McCrate, F.R., additional, Ryan, S., additional, Hannah, H., additional, Dewar, R.A.D., additional, MacIntyre, M., additional, Lalany, A., additional, Ruta, M., additional, Marrett, L., additional, Nishri, D.E., additional, McClure, C., additional, Vriends, K.A., additional, Bertrand, C., additional, Louchini, R., additional, Robb, K.I., additional, Stuart-Panko, H., additional, Demers, S., additional, Wright, S., additional, George, J.T., additional, Shen, X., additional, Brockhouse, J.T., additional, O'Brien, D.K., additional, Ward, K.C., additional, Almon, L., additional, Bates, J., additional, Rycroft, R., additional, Mueller, L., additional, Phillips, C., additional, Brown, H., additional, Cromartie, B., additional, Schwartz, A.G., additional, Vigneau, F., additional, MacKinnon, J.A., additional, Wohler, B., additional, Bayakly, A.R., additional, Clarke, C.A., additional, Glaser, S.L., additional, West, D., additional, Green, M.D., additional, Hernandez, B.Y., additional, Johnson, C.J., additional, Jozwik, D., additional, Charlton, M.E., additional, Lynch, C.F., additional, Huang, B., additional, Tucker, T.C., additional, Deapen, D., additional, Liu, L., additional, Hsieh, M.C., additional, Wu, X.C., additional, Stern, K., additional, Gershman, S.T., additional, Knowlton, R.C., additional, Alverson, J., additional, Copeland, G.E., additional, Rogers, D.B., additional, Lemons, D., additional, Williamson, L.L., additional, Hood, M., additional, Hosain, G.M., additional, Rees, J.R., additional, Pawlish, K.S., additional, Stroup, A., additional, Key, C., additional, Wiggins, C., additional, Kahn, A.R., additional, Schymura, M.J., additional, Leung, G., additional, Rao, C., additional, Giljahn, L., additional, Warther, B., additional, Pate, A., additional, Patil, M., additional, Schubert, S.S., additional, Rubertone, J.J., additional, Slack, S.J., additional, Fulton, J.P., additional, Rousseau, D.L., additional, Janes, T.A., additional, Schwartz, S.M., additional, Bolick, S.W., additional, Hurley, D.M., additional, Richards, J., additional, Whiteside, M.A., additional, Nogueira, L.M., additional, Herget, K., additional, Sweeney, C., additional, Martin, J., additional, Wang, S., additional, Harrelson, D.G., additional, Keitheri Cheteri, M.B., additional, Farley, S., additional, Hudson, A.G., additional, Borchers, R., additional, Stephenson, L., additional, Espinoza, J.R., additional, Weir, H.K., additional, Edwards, B.K., additional, Wang, N., additional, Yang, L., additional, Chen, J.S., additional, Song, G.H., additional, Gu, X.P., additional, Zhang, P., additional, Ge, H.M., additional, Zhao, D.L., additional, Zhang, J.H., additional, Zhu, F.D., additional, Tang, J.G., additional, Shen, Y., additional, Wang, J., additional, Li, Q.L., additional, Yang, X.P., additional, Dong, J., additional, Li, W., additional, Cheng, L.P., additional, Chen, J.G., additional, Huang, Q.H., additional, Huang, S.Q., additional, Guo, G.P., additional, Wei, K., additional, Chen, W.Q., additional, Zeng, H., additional, Demetriou, A.V., additional, Pavlou, P., additional, Mang, W.K., additional, Ngan, K.C., additional, Kataki, A.C., additional, Krishnatreya, M., additional, Jayalekshmi, P.A., additional, Sebastian, P., additional, Sapkota, S.D., additional, Verma, Y., additional, Nandakumar, A., additional, Suzanna, E., additional, Keinan-Boker, L., additional, Silverman, B.G., additional, Ito, H., additional, Nakagawa, H., additional, Hattori, M., additional, Kaizaki, Y., additional, Sugiyama, H., additional, Utada, M., additional, Katayama, K., additional, Narimatsu, H., additional, Kanemura, S., additional, Koike, T., additional, Miyashiro, I., additional, Yoshii, M., additional, Oki, I., additional, Shibata, A., additional, Matsuda, T., additional, Nimri, O., additional, Ab Manan, A., additional, Bhoo Pathy, N., additional, Chimedsuren, O., additional, Tuvshingerel, S., additional, Al Khater, A.H.M., additional, Al-Eid, H., additional, Jung, K.W., additional, Won, Y.J., additional, Chiang, C.J., additional, Lai, M.S., additional, Suwanrungruang, K., additional, Wiangnon, S., additional, Daoprasert, K., additional, Pongnikorn, D., additional, Geater, S.L., additional, Sriplung, H., additional, Eser, S., additional, Yakut, C.I., additional, Hackl, M., additional, Mühlböck, H., additional, Oberaigner, W., additional, Zborovskaya, A.A., additional, Aleinikova, O.V., additional, Henau, K., additional, Van Eycken, L., additional, Dimitrova, N., additional, Valerianova, Z., additional, Šekerija, M., additional, Zvolský, M., additional, Engholm, G., additional, Storm, H., additional, Innos, K., additional, Mägi, M., additional, Malila, N., additional, Seppä, K., additional, Jégu, J., additional, Velten, M., additional, Cornet, E., additional, Troussard, X., additional, Bouvier, A.M., additional, Faivre, J., additional, Guizard, A.V., additional, Bouvier, V., additional, Launoy, G., additional, Arveux, P., additional, Maynadié, M., additional, Mounier, M., additional, Fournier, E., additional, Woronoff, A.S., additional, Daoulas, M., additional, Clavel, J., additional, Le Guyader-Peyrou, S., additional, Monnereau, A., additional, Trétarre, B., additional, Colonna, M., additional, Cowppli-Bony, A., additional, Molinié, F., additional, Bara, S., additional, Degré, D., additional, Ganry, O., additional, Lapôtre-Ledoux, B., additional, Grosclaude, P., additional, Estève, J., additional, Bray, F., additional, Piñeros, M., additional, Sassi, F., additional, Stabenow, R., additional, Eberle, A., additional, Erb, C., additional, Nennecke, A., additional, Kieschke, J., additional, Sirri, E., additional, Kajueter, H., additional, Emrich, K., additional, Zeissig, S.R., additional, Holleczek, B., additional, Eisemann, N., additional, Katalinic, A., additional, Brenner, H., additional, Asquez, R.A., additional, Kumar, V., additional, Ólafsdóttir, E.J., additional, Tryggvadóttir, L., additional, Comber, H., additional, Walsh, P.M., additional, Sundseth, H., additional, Devigili, E., additional, Mazzoleni, G., additional, Giacomin, A., additional, Bella, F., additional, Castaing, M., additional, Sutera, A., additional, Gola, G., additional, Ferretti, S., additional, Serraino, D., additional, Zucchetto, A., additional, Lillini, R., additional, Vercelli, M., additional, Busco, S., additional, Pannozzo, F., additional, Vitarelli, S., additional, Ricci, P., additional, Pascucci, C., additional, Autelitano, M., additional, Cirilli, C., additional, Federico, M., additional, Fusco, M., additional, Vitale, M.F., additional, Usala, M., additional, Cusimano, R., additional, Mazzucco, W., additional, Michiara, M., additional, Sgargi, P., additional, Maule, M.M., additional, Sacerdote, C., additional, Tumino, R., additional, Di Felice, E., additional, Vicentini, M., additional, Falcini, F., additional, Cremone, L., additional, Budroni, M., additional, Cesaraccio, R., additional, Contrino, M.L., additional, Tisano, F., additional, Fanetti, A.C., additional, Maspero, S., additional, Candela, G., additional, Scuderi, T., additional, Gentilini, M.A., additional, Piffer, S., additional, Rosso, S., additional, Sacchetto, L., additional, Caldarella, A., additional, La Rosa, F., additional, Stracci, F., additional, Contiero, P., additional, Tagliabue, G., additional, Dei Tos, A.P., additional, Zorzi, M., additional, Zanetti, R., additional, Baili, P., additional, Berrino, F., additional, Gatta, G., additional, Sant, M., additional, Capocaccia, R., additional, De Angelis, R., additional, Liepina, E., additional, Maurina, A., additional, Smailyte, G., additional, Agius, D., additional, Calleja, N., additional, Siesling, S., additional, Visser, O., additional, Larønningen, S., additional, Møller, B., additional, Dyzmann-Sroka, A., additional, Trojanowski, M., additional, Góźdż, S., additional, Mężyk, R., additional, Grądalska-Lampart, M., additional, Radziszewska, A.U., additional, Didkowska, J.A., additional, Wojciechowska, U., additional, Błaszczyk, J., additional, Kępska, K., additional, Bielska-Lasota, M., additional, Kwiatkowska, K., additional, Forjaz, G., additional, Rego, R.A., additional, Bastos, J., additional, Silva, M.A., additional, Antunes, L., additional, Bento, M.J., additional, Mayer-da-Silva, A., additional, Miranda, A., additional, Coza, D., additional, Todescu, A.I., additional, Valkov, M.Y., additional, Adamcik, J., additional, Safaei Diba, C., additional, Primic-Žakelj, M., additional, Žagar, T., additional, Stare, J., additional, Almar, E., additional, Mateos, A., additional, Quirós, J.R., additional, Bidaurrazaga, J., additional, Larrañaga, N., additional, Díaz García, J.M., additional, Marcos, A.I., additional, Marcos-Gragera, R., additional, Vilardell Gil, M.L., additional, Molina, E., additional, Sánchez, M.J., additional, Franch Sureda, P., additional, Ramos Montserrat, M., additional, Chirlaque, M.D., additional, Navarro, C., additional, Ardanaz, E.E., additional, Moreno-Iribas, C.C., additional, Fernández-Delgado, R., additional, Peris-Bonet, R., additional, Galceran, J., additional, Khan, S., additional, Lambe, M., additional, Camey, B., additional, Bouchardy, C., additional, Usel, M., additional, Ess, S.M., additional, Herrmann, C., additional, Bulliard, J.L., additional, Maspoli-Conconi, M., additional, Frick, H., additional, Kuehni, C.E., additional, Schindler, M., additional, Bordoni, A., additional, Spitale, A., additional, Chiolero, A., additional, Konzelmann, I., additional, Dehler, S.I., additional, Matthes, K.L., additional, Rashbass, J., additional, Stiller, C., additional, Fitzpatrick, D., additional, Gavin, A., additional, Bannon, F., additional, Black, R.J., additional, Brewster, D.H., additional, Huws, D.W., additional, White, C., additional, Finan, P., additional, Allemani, C., additional, Bonaventure, A., additional, Carreira, H., additional, Coleman, M.P., additional, Di Carlo, V., additional, Harewood, R., additional, Liu, K., additional, Matz, M., additional, Montel, L., additional, Nikšić, M., additional, Rachet, B., additional, Sanz, N., additional, Spika, D., additional, Stephens, R., additional, Peake, M., additional, Chalker, E., additional, Newman, L., additional, Baker, D., additional, Soeberg, M.J., additional, Aitken, J., additional, Scott, C., additional, Stokes, B.C., additional, Venn, A., additional, Farrugia, H., additional, Giles, G.G., additional, Threlfall, T., additional, Currow, D., additional, You, H., additional, Hendrix, J., additional, and Lewis, C., additional

Published
2017
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216. Assembly of One-Dimensional Organic Luminescent Nanowires Based on Quinacridone Derivatives

Author

Bai Yang, Junhu Zhang, Dongge Ma, Dingke Zhang, Jia Wang, Jingying Zhang, Yue Wang, Yunfeng Zhao, and You H

Subjects
chemistry.chemical_classification, Materials science, Analytical chemistry, Nanowire, Nanotechnology, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, General Energy, Nanocrystal, chemistry, Quinacridone, Nano, Nanorod, Emission spectrum, Physical and Theoretical Chemistry, Luminescence, Alkyl
Abstract

The quinacridone derivatives N,N‘-dialkyl-1,3,8,10-tetramethylquinacridone (CnTMQA, n = 6, 10, 14) were used as building blocks to assemble luminescent nano- and microscale wires. It was demonstrated that CnTMQA with different lengths of alkyl chains display obviously different wire formation properties. C10TMQA and C14TMQA showed a stronger tendency to form 1-D nano- and microstructures compared with C6TMQA. The C10TMQA molecules could be employed to fabricate the wires with different diameters, which exhibited a size-dependent luminescence property. The emission spectrum of the C10TMQA wires with diameters of 200−500 nm shows a broad emission band at 560 nm and a shoulder at around 535 nm, while the emission spectrum of the C10TMQA wires with diameters of 2−3 μm reveals a narrower emission band at 563 nm. For the CnTMQA-based samples with different morphologies, the emission property change tendency agrees with that of the powder X-ray diffraction patterns of these samples.

Published
2007

217. New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development

Author

Adel K. El-Naggar, Li Mao, You H. Fan, Edward S. Kim, Jing Wang, Jean Pierre J. Issa, Lei Feng, Curtis R. Pickering, Scott M. Lippman, J. Jack Lee, Jean Philippe Foy, Jaroslav Jelinek, Steven H. Lin, Pierre Saintigny, Wenhua Lang, Waun Ki Hong, Vassiliki A. Papadimitrakopoulou, William N. William, Mitchell J. Frederick, Jeffrey N. Myers, and Li Zhang

Subjects
Male, Cancer Research, chemistry.chemical_compound, Angiotensin, 2.1 Biological and endogenous factors, Aetiology, Promoter Regions, Genetic, Cancer, Mouth neoplasm, Methylation, Phenotype, Oncology, CpG site, DNA methylation, Carcinoma, Squamous Cell, Disease Progression, Mouth Neoplasms, Female, Sequence Analysis, Receptor, Type 1, Clinical Sciences, Oncology and Carcinogenesis, Biology, Article, Receptor, Angiotensin, Type 1, Disease-Free Survival, Cell Line, Promoter Regions, Rare Diseases, Genetic, Clinical Research, Genetics, Humans, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Gene, Proportional Hazards Models, Carcinoma, Promoter, Sequence Analysis, DNA, DNA, DNA Methylation, Molecular biology, stomatognathic diseases, chemistry, Squamous Cell, CpG Islands, Digestive Diseases, Precancerous Conditions, DNA hypomethylation, Follow-Up Studies
Abstract

DNA promoter methylation of tumor suppressor genes and global DNA hypomethylation are common features of head and neck cancers. Our goal was to identify early DNA methylation changes in oral premalignant lesions (OPL) that may serve as predictive markers of developing oral squamous cell carcinoma (OSCC). Using high-throughput DNA methylation profiles of 24 OPLs, we found that the top 86 genes differentially methylated between patients who did or did not develop OSCC were simultaneously hypermethylated, suggesting that a CpG island methylation phenotype may occur early during OSCC development. The vast majority of the 86 genes were nonmethylated in normal tissues and hypermethylated in OSCC versus normal mucosa. We used pyrosequencing in a validation cohort of 44 patients to evaluate the degree of methylation of AGTR1, FOXI2, and PENK promoters CpG sites that were included in the top 86 genes and of LINE1 repetitive element methylation, a surrogate of global DNA methylation. A methylation index was developed by averaging the percent methylation of AGTR1, FOXI2, and PENK promoters; patients with a high methylation index had a worse oral cancer–free survival (P = 0.0030). On the other hand, patients with low levels of LINE1 methylation had a significantly worse oral cancer–free survival (P = 0.0153). In conclusion, AGTR1, FOXI2, and PENK promoter methylation and LINE1 hypomethylation may be associated with an increased risk of OSCC development in patients with OPLs. Cancer Prev Res; 8(11); 1027–35. ©2015 AACR.

Published
2015

219. Global surveillance of cancer survival 1995-2009: Analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)

Author

Allemani, C, Weir, HK, Carreira, H, Harewood, R, Spika, D, Wang, XS, Bannon, F, Ahn, JV, Johnson, CJ, Bonaventure, A, Marcos-Gragera, R, Stiller, C, Azevedo E Silva, G, Chen, WQ, Ogunbiyi, OJ, Rachet, B, Soeberg, MJ, You, H, Matsuda, T, Bielska-Lasota, M, Storm, H, Tucker, TC, Coleman, MP, Bouzbid, S, Hamdi-Chérif, M, Zaidi, Z, Bah, E, Swaminathan, R, Nortje, SH, Stefan, CD, El Mistiri, MM, Bayo, S, Malle, B, Manraj, SS, Sewpaul-Sungkur, R, Fabowale, A, Bradshaw, D, Somdyala, NIM, Abdel-Rahman, M, Jaidane, L, Mokni, M, Kumcher, I, Moreno, F, González, MS, Laura, E, Pugh, FV, Torrent, ME, Carballo Quintero, B, Fita, R, Garcilazo, D, Giacciani, PL, Diumenjo, MC, Laspada, WD, Green, MA, Lanza, MF, Ibañez, SG, Lima, CA, Lobo, E, Daniel, C, Scandiuzzi, C, De Souza, PCF, Del Pino, K, Laporte, C, Curado, MP, de Oliveira, JC, Veneziano, CLA, Veneziano, DB, Alexandre, TS, Verdugo, AS, Koifman, S, Galaz, JC, Moya, JA, Herrmann, DA, Jofre, AM, Uribe, CJ, Bravo, LE, Lopez Guarnizo, G, Jurado, DM, Yepes, MC, Galán, YH, Torres, P, Martínez-Reyes, F, Jaramillo, L, Quinto, R, Cueva, P, Yépez, J, Torres-Cintrón, CR, Tortolero-Luna, G, Alonso, R, Barrios, E, Russell, C, Shack, L, Coldman, AJ, Woods, RR, Noonan, G, Turner, D, Kumar, E, Zhang, B, McCrate, FR, and Ryan, S

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Infant, Newborn, Infant, Middle Aged, Global Health, Survival Analysis, Young Adult, Age Distribution, General & Internal Medicine, Neoplasms, Child, Preschool, Humans, Female, Registries, Sex Distribution, Child, Aged
Abstract

© 2015 Allemani et al. Open Access article distributed under the terms of CC BY. Background Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. Methods Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75 000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. Findings 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. Interpretation International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems. Funding Canadian Partnership Against Cancer (Toronto, Canada), Cancer Focus Northern Ireland (Belfast, UK), Cancer Institute New South Wales (Sydney, Australia), Cancer Research UK (London, UK), Centers for Disease Control and Prevention (Atlanta, GA, USA), Swiss Re (London, UK), Swiss Cancer Research foundation (Bern, Switzerland), Swiss Cancer League (Bern, Switzerland), and University of Kentucky (Lexington, KY, USA).

Published
2015

220. Regulation of DGKεActivity and Substrate Acyl Chain Specificity by Negatively Charged Phospholipids

Author

Bozelli, José Carlos, Yune, Jenny, Hou, You H., Chatha, Preet, Fernandes, Alexia, Cao, Zihao, Tong, Yufeng, and Epand, Richard M.

Abstract

Diacylglycerol kinase ε(DGKε) is a membrane-bound enzyme that catalyzes the ATP-dependent phosphorylation of diacylglycerol to form phosphatidic acid (PA) in the phosphatidylinositol cycle. DGKεlacks a putative regulatory domain and has recently been reported to be regulated by highly curved membranes. To further study the effect of other membrane properties as a regulatory mechanism of DGKε, our work reports the effect of negatively charged phospholipids on DGKεactivity and substrate acyl chain specificity. These studies were conducted using purified DGKεand detergent-free phospholipid aggregates, which present a more suitable model system to access the impact of membrane physical properties on membrane-active enzymes. The structural properties of the different model membranes were studied by means of differential scanning calorimetry and 31P-NMR. It is shown that the enzyme is inhibited by a variety of negatively charged phospholipids. However, PA, which is a negatively charged phospholipid and the product of DGKεcatalyzed reaction, showed a varied regulatory effect on the enzyme from being an activator to an inhibitor. The type of feedback regulation of DGKεby PA depends on the particular PA molecular species as well as the physical properties of the membrane that the enzyme binds to. In the presence of highly packed PA-rich domains, the enzyme is activated. However, its acyl chain specificity is only observed in liposomes containing 1,2-dioleoyl PA in the presence of Ca2+. It is proposed that to endow the enzyme with its substrate acyl chain specificity, a highly dehydrated (hydrophobic) membrane interface is needed. The presence of an overlap of mechanisms to regulate DGKεensures proper phosphatidylinositol cycle function regardless of the trigged stimulus and represents a sophisticated and specialized manner of membrane-enzyme regulation.

Published
2020
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221. Highly Enhanced Luminescence from Single-Crystalline C60·1m-xylene Nanorods

Author

Mingguang Yao, Tian Cui, Dingke Zhang, Bingbing Liu, Yuanyuan Hou, Shidan Yu, Guangtian Zou, Dongge Ma, You H, Bertil Sundqvist, Dedi Liu, and Lin Wang

Subjects
Materials science, Photoluminescence, Orders of magnitude (temperature), Icosahedral symmetry, General Chemical Engineering, Xylene, Nanotechnology, General Chemistry, chemistry.chemical_compound, Crystallography, symbols.namesake, chemistry, Materials Chemistry, symbols, Molecule, Nanorod, van der Waals force, Raman spectroscopy
Abstract

Single-crystalline C60·1m-xylene nanorods with a hexagonal structure were successfully synthesized by evaporating a C60 solution in m-xylene at room temperature. The ratio of the length to the diameter of the nanorods can be controlled in the range of ≈10 to over 1000 for different applications. The photoluminescence (PL) intensity of the nanorods is about 2 orders of magnitude higher than that for pristine C60 crystals in air. Both UV and Raman results indicate that there is no charge transfer between C60 and m-xylene. It was found that the interaction between C60 and m-xylene molecules is of the van der Waals type. This interaction reduces the icosahedral symmetry of C60 molecule and induces strong PL from the solvate nanorods.

Published
2006

222. Novel 〈110〉-Oriented Organic−Inorganic Perovskite Compound Stabilized by N-(3-Aminopropyl)imidazole with Improved Optical Properties

Author

Cuikun Lin, Wen Wang, Ziyong Cheng, Yinyan Li, Guoli Zheng, J. Lin, and You H

Subjects
Photoluminescence, Materials science, Ligand, General Chemical Engineering, Inorganic chemistry, Halide, General Chemistry, Crystal structure, Crystallography, chemistry.chemical_compound, chemistry, Materials Chemistry, Imidazole, Hydrobromic acid, Thin film, Perovskite (structure)
Abstract

In the organic−inorganic perovskites family, the 〈100〉-oriented type has been extensively investigated as a result of its unique magnetic, optical, and electrical properties, and only one type of 〈110〉-oriented hybrid perovskite stabilized by methylammonium and iodoformamidinium cations or the latter themselves has been known so far. In this paper, another novel 〈110〉-oriented organic−inorganic perovskite (C6H13N3)PbBr4 (compound 1) has been prepared by reacting N-(3-aminopropyl)imidazole (API) with PbBr2 in hydrobromic acid. The crystal structure is determined, which indicates that the perovskite is stabilized by API. The introduction of the optically active organic ligand API into the hybrid perovskite results in a red shift and a great enhancement of photoluminescence in the perovskite with respect to organic ligand API itself. These results have been explained according to calculation based on density-functional theory. Moreover, the excellent film processing ability for the perovskite (C6H13N3)PbBr4 ...

Published
2006

223. Knocking down PFL can improve myocardial ischemia/reperfusion injury in rats by up-regulating heat shock protein-20.

Author

YIN, R.-L., YOU, H., WU, Y.-M., YE, F.-L., GU, W.-X., and SHEN, J.

Abstract

OBJECTIVE: To investigate the effect and mechanism of long non-coding ribonucleic acid (lncRNA) PFL on myocardial ischemia/reperfusion (I/R) injury in rats, and to provide a reference for the prevention and treatment of myocardial infarction (MI) in clinic. MATERIALS AND METHODS: According to the random number table, 60 male Sprague-Dawley (SD) rats were randomly divided into 3 groups: Control group (n=20), I/R group (n=20), and I/R + PFL small interfering ribonucleic acid (siRNA) group (n=20). The I/R model was established by ligating the left anterior descending coronary artery (LAD) and then recanalizing it. PFL siRNAs were injected intravenously into the tail vein of rats in I/R + PFL siRNA group to construct a PFL knockout model. Triphenyl tetrazolium chloride (TTC) test was used to detect the infarction area of each group. Echocardiography was adopted to measure the ejection fraction [EF (%)] and fraction shortening [FS (%)] of rats in each group. Hematoxylin and eosin (H&E) staining was applied to detect the morphological changes in myocardial cells in each group. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was conducted to detect the apoptosis levels of myocardial cells and fibroblasts in heart tissues in each group. Meanwhile, the protein expression levels of apoptosis-related genes, Bcl-2-associated X protein (BAX), and Bcl-2, were measured via Western blotting. Also, the expression level of heat shock protein 20 (HSP-20) in the heart of three groups of rats was examined using immunohistochemical staining. Finally, the effects of PFL siRNAs on the expression level of HSP-20 were detected via Western blotting. RESULTS: PFL siRNAs could significantly improve I/R-induced cardiac insufficiency in rats, thus increasing EF (%) and FS (%) (p<0.05). Besides, PFL siRNAs could remarkably inhibit cardiac infarction caused by I/R injury and reduce the infarction area from (59.54±3.45)% to (24.85±1.30)% (p<0.05). H&E staining results manifested that, compared with those in I/R group, the cardiac myofilament was better in alignment, degradation and necrosis were milder, and cell edema was notably reduced in I/R + PFL siRNA group. Immunohistochemistry and Western blotting results showed that PFL siRNAs could remarkably reverse the decrease in the HSP-20 expression caused by I/R (p<0.05). CONCLUSIONS: We found that PFL knockdown can significantly improve the myocardial injury caused by I/R and improve the cardiac function in rats. The mechanism may be related to the activation of HSP-20 by PFL siRNAs. Therefore, PFL is expected to become a new target for the treatment of MI. [ABSTRACT FROM AUTHOR]

Published
2019

224. Automatic extraction of flood inundation areas from SAR images: a case study of Jilin, China during the 2017 flood disaster.

Author

Wang, F., Wan, L., Zhang, T., You, H. J., and Liu, M.

Subjects
FLOOD control, SYNTHETIC aperture radar, PROBABILITY density function, HAZARD mitigation
Abstract

Flood is one of the most frequent and widespread natural hazards globally, which can cause tremendous economic damage and human casualties. As such, flood event monitoring is essential, for which Synthetic Aperture Radar (SAR), with high spatial resolution as well as all-weather and all-time capabilities, can provide high-quality data support. However, algorithms for automatic flood inundation mapping that do not require ancillary data are limited. In this study, we propose a hybrid methodology that combines automatic thresholds selection, pixel- and object-based classification, and bidirectional region growing method for extracting flood inundation areas. This is a fully automatic approach that does not require the assistance of ancillary data. Firstly, the gamma distribution is used to estimate the probability density function (PDF) of 'open water' and to set thresholds. Then, we introduce a two-step classification approach, applying the pixel- and object-based classifications; the former is easy to implement with low computational complexity and stable performance, whereas the latter can reduce noise pixels and is less sensitive to SAR intrinsic speckle. The two-step classification is employed to yield core flooded and non-flooded regions that are used as seeds for region growing. Furthermore, we propose a bidirectional region growing approach that grows regions for flooded and non-flooded regions simultaneously to eliminate areas of uncertainty, while minimizing under- and over-detection. We verified the proposed approach by applying it to real flood events that occurred in Jilin, China on 13 July 2017 and 20 July 2017. The experimental results demonstrate the effectiveness and reliability of the proposed approach. [ABSTRACT FROM AUTHOR]

Published
2019
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225. In-situ x-ray reflectivity study of incipient oxidation of Pt(111) surface in electrolyte solutions.

Author

You, H., Zurawski, D. J., Nagy, Z., and Yonco, R. M.

Subjects
*ELECTROLYTIC reduction, *OXIDATION, *ELECTROLYTE solutions
Abstract

Electrochemical oxidation causes the lifting of Pt atoms of the surface layer, substantiating a place-exchange mechanism. Furthermore, for a charge transfer of ≲1.7e-/Pt atom, the flat surface is recovered by reduction, while the surface is irreversibly roughened by more excessive oxidation. Roughening involves only the atoms in the top layer. [ABSTRACT FROM AUTHOR]

Published
1994
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226. Al–Ga interdiffusion, carbon acceptor diffusion, and hole reduction in carbon-doped Al0.4Ga0.6As/GaAs superlattices: The As4 pressure effect.

Author

You, H. M., Tan, T. Y., Gösele, U. M., Lee, S.-T., Höfler, G. E., Hsieh, K. C., and Holonyak, N.

Subjects
*CARBON, *DIFFUSION, *SUPERLATTICES
Abstract

Presents a study which examined Al-Ga interdiffusion, carbon acceptor diffusion and hole reduction in carbon doped Al[sub0.4]Ga[sub0.6]As/GaAs superlattices annealed under different ambient As[sub4] pressure conditions. Experimental details; Results and discussion; Conclusions.

Published
1993
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227. Disordering in 69GaAs/71GaAs isotope superlattice structures.

Author

Tan, T. Y., You, H. M., Yu, S., Gösele, U. M., Jäger, W., Boeringer, D. W., Zypman, F., Tsu, R., and Lee, S.-T.

Subjects
*GALLIUM arsenide, *SUPERLATTICES, *MOLECULAR beam epitaxy, *SECONDARY ion mass spectrometry, *TRANSMISSION electron microscopy
Abstract

Investigates gallium self-diffusion in gallium arsenide by disordering reactions. Application of undoped gallium arsenide (GaAs)/GaAs isotope superlattice structures grown by molecular beam epitaxy; Characterizations by secondary ion mass spectrometry, capacitance-voltage and transmission electron microscopy; Cause of the release of Ga vacancies into the superlattice layers.

Published
1992
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228. Raman scattering and x-ray diffractometry studies of epitaxial TiO2 and VO2 thin films and multilayers on α-Al2O3(1120).

Author

Foster, C. M., Chiarello, R. P., Chang, H. L. M., You, H., Zhang, T. J., Frase, H., Parker, J. C., and Lam, D. J.

Subjects
RAMAN effect, OPTICAL diffraction, EPITAXY, X-rays
Abstract

Presents a study that investigated Raman scattering and x-ray diffractometry of epitaxial TiO[sub2] and VO[sub2] thin films and multilayers on α-Al[sub2]O[sub3]. Analysis of x-ray diffraction results; Discussion on the adherence of single-layer films to Raman selection rules of TiO[sub2] and VO[sub2] single crystals; Details on growth conditions and film composition.

Published
1993
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229. Sol−Gel-Derived BPO4/Ba2+ as a New Efficient and Environmentally-Friendly Bluish-White Luminescent Material

Author

You H, Yong-Chun Luo, Zewei Quan, Jiye Fang, Jun-Wu Zhang, Jun Lin, and Chensheng Lin

Subjects
Photoluminescence, Materials science, General Chemical Engineering, Analytical chemistry, Quantum yield, General Chemistry, law.invention, Condensed Matter::Materials Science, law, Materials Chemistry, Light emission, Emission spectrum, Chromaticity, Electron paramagnetic resonance, Luminescence, Spectroscopy
Abstract

In this paper, BPO4 and Ba2+-doped BPO4 powder samples were prepared by the sol-gel process using glycerol and poly(ethylene glycol) as additives. The structure and optical properties of the resulting samples were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM), diffuse reflection spectra, photoluminescence (PL) excitation and emission spectra, quantum yield, kinetic decay, and electron paramagnetic resonance (EPR), respectively. It was found that the undoped BPO4 showed a weak purple blue emission (409 nm, lifetime 6.4 ns) due to the carbon impurities involved in the host lattice. Doping Ba2+ into BPO4 resulted in oxygen-related defects as additional emission centers which enhanced the emission intensity greatly (> 10x) and shifted the emission to a longer-wavelength region (lambda(max) = 434 nm; chromaticity coordinates: x = 0.174, y = 0. 187) with a bluish-white color. The highest emission intensity was obtained ;when doping 6 mol % Ba2+ in BPO4, which has a quantum yield as high as 31%. The luminescent mechanisms of BPO4 and Ba2+-doped BPO4 were discussed in detail according to the existing models for silica-based materials.

Published
2005

230. Insect cells–Baculovirus system: Factors affecting growth and low MOI infection

Author

Jose C. Merchuk, You H. Zhang, and Giora Enden

Subjects
Environmental Engineering, Insect cell, Inoculation, viruses, Cell, Biomedical Engineering, Insect cell culture, Bioengineering, Biology, Virology, Virus, Multiplicity of infection, medicine.anatomical_structure, medicine, Infection dynamics, Gene, Biotechnology
Abstract

The use of low multiplicity of infection (MOI) for the production of baculovirus in insect cell sytems is an attractive alternative for large-scale production processes. Such processes may be focused on the production of biological insecticides or on the expression of medically useful foreign genes. In the present study, the effect of MOI, cell inoculum age and inoculation procedure (carry-over of spent medium from the pre-culture) was studied. While some influences of inoculum age and medium were found, the overhelming effect is related to MOI. The data obtained describe the dynamics of the changes of non-occluded virus (NOV) in time, giving a useful insight into the mechanism of the cell–virus system.

Published
2005

231. Differences in impact of Aboriginal and Torres Strait Islander status on cancer stage and survival by level of socio-economic disadvantage and remoteness of residence-A population-based cohort study in Australia

Author

Tervonen, HE, Aranda, S, Roder, D, Walton, R, Baker, D, You, H, Currow, D, Tervonen, HE, Aranda, S, Roder, D, Walton, R, Baker, D, You, H, and Currow, D

Abstract

© 2016. Background: Aboriginal and Torres Strait Islander people (referred to in this paper as "Aboriginal people") generally have lower cancer survivals and more advanced stages at diagnosis than non-Aboriginal people. There is conflicting evidence on whether these disparities vary by socio-economic disadvantage and geographic remoteness. This study examines variations in these disparities in New South Wales (NSW), Australia. Methods: Data for cancers diagnosed in 2000-2008 were extracted from the NSW Cancer Registry (n = 264,219). Missing Aboriginal status (13.3%) was multiply imputed. Logistic regression and competing risk regression models were used to examine likelihood of advanced summary stage and risk of cancer death among Aboriginal compared with non-Aboriginal people by socio-economic disadvantage (categorised into quintiles 1: least disadvantaged-5: most disadvantaged) and remoteness. Results: Aboriginal people showed a general pattern of more advanced stage at diagnosis compared with non-Aboriginal people across socio-economic disadvantage and remoteness categories. After adjusting for demographic factors, year of diagnosis, summary stage and cancer site, Aboriginal people living outside the least disadvantaged areas had an increased risk of cancer death compared with non-Aboriginal people living in similar areas (sub-hazard ratio SHR 1.41, 95% confidence interval CI 1.09-1.81; SHR 1.59, 95%CI 1.31-1.93; SHR 1.42, 95%CI 1.22-1.64 and SHR 1.34, 95%CI 1.22-1.48 for quintiles 2-5, respectively). Compared with non-Aboriginal people, Aboriginal people had an elevation in the risk of cancer death irrespective of the remoteness, with the most pronounced elevations detected in remote/very remote areas (SHR 1.56, 95%CI 1.10-2.21). Conclusion: Compared with non-Aboriginal people, Aboriginal people had a higher risk of cancer death and higher likelihood of more advanced stage across socio-economic disadvantage and remoteness categories. All areas appear to require

Published
2016

233. What factors are predictive of surgical resection and survival from localised nonsmall cell lung cancer?

Author

Currow, DC, You, H, Aranda, S, McCaughan, BC, Morrell, S, Baker, DF, Walton, R, and Roder, DM

Subjects
Aged, 80 and over, Male, Lung Neoplasms, Time Factors, Middle Aged, Prognosis, Risk Assessment, Survival Rate, Risk Factors, General & Internal Medicine, Carcinoma, Non-Small-Cell Lung, Humans, Female, Registries, New South Wales, Pneumonectomy, Neoplasm Staging, Retrospective Studies, Follow-Up Studies, Aged
Abstract

© 2014, Australasian Medical Publishing Co. Ltd. All rights reserved. Objective: To investigate opportunities to reduce lung cancer mortality after diagnosis of localised non-small cell lung cancer (NSCLC) in New South Wales through surgical resection.Main outcome measures: Resection rates and lung cancer mortality.Design, patients and setting: In this cohort study, resection rates and lung cancer mortality risk were explored using multivariate logistic regression and competing risk regression, respectively. Data for 3040 patients were extracted from the NSW Central Cancer Registry for the diagnostic period 1 January 2003 to 31 December 2007. Subset analyses for patients at low surgical risk indicated resection rates and outcomes under ideal circumstances.Results: The resection rate in NSW was estimated to be between 38% and 43%, peaking at 59% by local health district (LHD) of residence. Not having a resection was associated with older age, lower socioeconomic status, lack of private health insurance, and residence by LHD. Adjusted 5-year cumulated probabilities of death were 76% in absence of resection, 30% for wedge resection, 18% for segmental resection, 22% for lobectomy and 45% for pneumonectomy. Of 255 “low surgical risk” patients, 71% had a resection. Those not receiving a resection had a higher probability of death (adjusted subhazard ratio, 14.1; 95% CI, 7.2–27.5). If the low overall resection rate of 38%–43% in NSW were increased to 59% (the highest LHD resection rate), the proportion of all patients with localised NSCLC dying of NSCLC in the 5 years from diagnosis would decrease by about 10%, based on differences in probabilities of death by resection estimated in this study.Conclusions: Potential exists to reduce deaths from NSCLC in NSW through increased resection.

Published
2014

243. 3D scan to product design: Methods, techniques, and cases

Author

Lee, W. (author), Lee, B. (author), Kim, S. (author), Jung, H. (author), Jeon, E. (author), Choi, T. (author), You, H. (author), Lee, W. (author), Lee, B. (author), Kim, S. (author), Jung, H. (author), Jeon, E. (author), Choi, T. (author), and You, H. (author)

Abstract

3D scanning technology has derived great opportunities for ergonomic product designs. This paper is aimed to introduce various research cases and methods based on 3D scanning have conducted by an ergonomics laboratory in South Korea. Sizing systems and representative 3D models developed on anthropometric measurements and 3D scan images with technical know-how were applied to the design of various products. Head, face, ear, upper limb, and waist parts, and full body in seated were anthropometrically analyzed for the design of headwear (e.g., helmet, goggle, and headphone), oxygen mask, earphone, arm-wear (e.g., watch, armband), hip protector, and vehicle seat, Customized software for the efficient analyses such as measurement of anthropometric dimensions, analysis of sizing systems, extraction of representative models, and virtual fit evaluation between products and the body were developed and applied in the product design process with massive 3D images. Representative models (e.g., torso and head) were printed in 3D for effective usage to the design and evaluation of related products. Advanced methods and techniques such as finite element modeling, morphing, and skin deformation have been applied to 3D scanned images for an advanced design of product shapes in further researches., Industrial Design, Industrial Design Engineering

Published
2015

245. Wealth transfers via equity transactions

Author

Sloan, RG, Sloan, RG, You, H, Sloan, RG, Sloan, RG, and You, H

Abstract

Previous research indicates that firms issue shares when their stock is overpriced and repurchase shares when their stock is underpriced. Such transactions transfer wealth from transacting stockholders to ongoing stockholders. We quantify the magnitude of these wealth transfers and analyze their implications. Strikingly, we find that for the average firm-year, these wealth transfers approximate 40% of net income. We also find that these wealth transfers can be predicted using a variety of firm characteristics and that future wealth transfers are an important determinant of current stock prices.

Published
2015

246. New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development.

Author

Foy, Jean-Philippe, Foy, Jean-Philippe, Pickering, Curtis R, Papadimitrakopoulou, Vassiliki A, Jelinek, Jaroslav, Lin, Steven H, William, William N, Frederick, Mitchell J, Wang, Jing, Lang, Wenhua, Feng, Lei, Zhang, Li, Kim, Edward S, Fan, You H, Hong, Waun K, El-Naggar, Adel K, Lee, J Jack, Myers, Jeffrey N, Issa, Jean-Pierre, Lippman, Scott M, Mao, Li, Saintigny, Pierre, Foy, Jean-Philippe, Foy, Jean-Philippe, Pickering, Curtis R, Papadimitrakopoulou, Vassiliki A, Jelinek, Jaroslav, Lin, Steven H, William, William N, Frederick, Mitchell J, Wang, Jing, Lang, Wenhua, Feng, Lei, Zhang, Li, Kim, Edward S, Fan, You H, Hong, Waun K, El-Naggar, Adel K, Lee, J Jack, Myers, Jeffrey N, Issa, Jean-Pierre, Lippman, Scott M, Mao, Li, and Saintigny, Pierre

Abstract

DNA promoter methylation of tumor suppressor genes and global DNA hypomethylation are common features of head and neck cancers. Our goal was to identify early DNA methylation changes in oral premalignant lesions (OPL) that may serve as predictive markers of developing oral squamous cell carcinoma (OSCC). Using high-throughput DNA methylation profiles of 24 OPLs, we found that the top 86 genes differentially methylated between patients who did or did not develop OSCC were simultaneously hypermethylated, suggesting that a CpG island methylation phenotype may occur early during OSCC development. The vast majority of the 86 genes were nonmethylated in normal tissues and hypermethylated in OSCC versus normal mucosa. We used pyrosequencing in a validation cohort of 44 patients to evaluate the degree of methylation of AGTR1, FOXI2, and PENK promoters CpG sites that were included in the top 86 genes and of LINE1 repetitive element methylation, a surrogate of global DNA methylation. A methylation index was developed by averaging the percent methylation of AGTR1, FOXI2, and PENK promoters; patients with a high methylation index had a worse oral cancer-free survival (P = 0.0030). On the other hand, patients with low levels of LINE1 methylation had a significantly worse oral cancer-free survival (P = 0.0153). In conclusion, AGTR1, FOXI2, and PENK promoter methylation and LINE1 hypomethylation may be associated with an increased risk of OSCC development in patients with OPLs.

Published
2015

247. Multifunctional luminescent nanomaterials from NaLa(MoO 4) 2:Eu 3+ /Tb 3+ with tunable decay lifetimes, emission colors, and enhanced cell viability

Author

Yang, M, Liang, Y, Gui, Q, Zhao, B, Jin, D, Lin, M, Yan, L, You, H, Dai, L, Liu, Y, Yang, M, Liang, Y, Gui, Q, Zhao, B, Jin, D, Lin, M, Yan, L, You, H, Dai, L, and Liu, Y

Abstract

A facile, but effective, method has been developed for large-scale preparation of NaLa(MoO 4) 2 nanorods and microflowers co-doped with Eu 3+ and Tb 3+ ions (abbreviated as: NLM:Ln 3+). The as-synthesized nanomaterials possess a pure tetragonal phase with variable morphologies from shuttle-like nanorods to microflowers by controlling the reaction temperature and the amount of ethylene glycol used. Consequently, the resulting nanomaterials exhibit superb luminescent emissions over the visible region from red through yellow to green by simply changing the relative doping ratios of Eu 3+ to Tb 3+ ions. Biocompatibility study indicates that the addition of NLM:Ln 3+ nanomaterials can stimulate the growth of normal human retinal pigment epithelium (ARPE-19) cells. Therefore, the newly-developed NaLa(MoO 4) 2 nanomaterials hold potentials for a wide range of multifunctional applications, including bioimaging, security protection, optical display, optoelectronics for information storage, and cell stimulation.

Published
2015

248. Effect of 5′‐inosine monophosphate (IMP) and 5′‐guanosine monophosphate (GMP) on the growth, immunity and muscle composition of turbot, Scophthalmus maximus (Linnaeus, 1758).

Author

Li, M., Chen, Y., Xia, S., Zhao, W., Li, N., You, H., Yang, L., Wang, X., Rajkumar, M., and Geng, X.

Subjects
GUANYLIC acid, PSETTA maxima, NUCLEOTIDES, ACID phosphatase, AQUACULTURE industry
Abstract

Abstract: We evaluated the effect of different concentrations of 5′‐inosine monophosphate (IMP) and 5′‐guanosine monophosphate (GMP) on the growth, immunity and muscle composition of turbot Scophthalmus maximus. Eight diets (containing no IMP or GMP, or 0.5 g/kg IMP, 1.0 g/kg IMP, 2.0 g/kg IMP, 0.5 g/kg GMP, 1.0 g/kg GMP, 2.0 g/kg GMP, or 0.5 g/kg IMP plus 0.5 g/kg GMP) were prepared. A total of 360 fish (average body weight of 105 g) were randomly selected and placed in groups into 24 plastic aquaria (8 treatments × 3 replicates × 15 individuals per plastic aquaria). The tanks were maintained at the temperature of 15 ± 2°C. The experimental diets were fed for 60 days. The specific growth rate (SGR) was significantly higher in S. maximus fed with IMP or GMP compared with fish fed neither IMP nor GMP. The highest SGR was observed in fish fed with 1.0 g/kg IMP. Supplementation with these dietary nucleotides had a positive, but not significant effect on the activity of superoxide dismutase, alkaline phosphatase and acid phosphatase. There was a significant difference in the moisture and crude lipid content of muscle from S. maximus fed the different diets compared with control fish. The highest moisture content was 83.44 for a diet of 0.5 g/kg IMP plus 0.5 g/kg GMP, which was also significantly higher when compared to fish fed alternative diets. The crude lipid content of S. maximus fed diets containing either IMP or GMP was significantly higher than those fed diets without IMP or GMP. Thus, according to these results, the optimal level of dietary IMP is 1.0 g/kg, which correlates with the largest increase in growth performance of S. maximus. [ABSTRACT FROM AUTHOR]

Published
2018
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249. The importance of dermoscopy for the diagnosis of acquired bilateral telangiectatic macules: the angioid streak pattern reveals underlying chronic liver disease.

Author

Kim, G.‐W., Shin, K., Kim, T.‐W., You, H.‐S., Jin, H.‐J., Shim, W.‐H., Kim, H.‐S., Ko, H.‐C., Kim, B.‐S., and Kim, M.‐B.

Subjects
LIVER disease diagnosis, CHRONIC diseases, ANGIOID streaks, RETINAL diseases, PATIENT selection
Abstract

Abstract: Background: Acquired bilateral telangiectatic macules (ABTM) are a newly recognized disease entity, which manifest as multiple telangiectatic pigmented macules confined mostly to the upper arms. Objectives: To evaluate clinical and dermoscopic features in a group of 50 patients with ABTM and to determine the diagnostic usefulness of dermoscopy in ABTM. Methods: Patients were selected from two tertiary teaching hospitals in Korea [Pusan National University Hospitals (Busan and Yangsan)]. Fifty patients (41 males and 9 females; mean age 48.1 years; range 26–78 years) with ABTM were included in the study. The dermoscopic findings were graded using a 4‐point scale: none (0), mild (1), moderate (2) and severe (3). In addition, the results of 23 patients with and 27 patients without chronic liver disease (CLD) were compared to determine whether the presence of CLD affects dermoscopic findings. Results: Three distinct dermoscopic patterns were observed; brown pigmentations, telangiectasia (linear‐irregular vessels) and an angioid streak pattern. Brown pigmentation in the group without CLD had higher severity score than those in CLD group (mean score: 2.00 vs. 1.48, P = 0.033). However, mean telangiectasia severity score was higher in the CLD group (2.14 vs. 1.39, P < 0.001). The angioid streak pattern was more severe and more common in patients with CLD than in those without [1.37 vs. 0.35 (P < 0.001) and 63.0% vs. 26.1%, respectively]. Conclusions: Detailed observations with dermoscopy can provide first clues of the presence of ABTM and underlying chronic liver disease. [ABSTRACT FROM AUTHOR]

Published
2018
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250. Effect of layering and doping on the magnetic anisotropy of the layered manganites La[sub 2-2x]Sr[sub 1+2x]Mn[sub 2]O[sub 7] (x=0.3-0.4).

Author

Welp, U., Berger, A., Vlasko-Vlasov, V. K., You, H., Gray, K. E., and Mitchell, J. F.

Subjects
MANGANITE, ANISOTROPY, MAGNETIZATION, MAGNETIC properties
Abstract

Magnetization experiments were performed on a series of single crystals of the bilayer manganites La[sub 2-2x]Sr[sub 1+2x]Mn[sub 2]O[sub 7]. The magnetic anisotropy constants were determined by fitting expressions based on the tetragonal anisotropy energy to the magnetization curves. It is shown that there is a significant dipolar contribution to the first order anisotropy constant arising from the layered crystal structure. This contribution determines the magnetization direction in the doping range x=0.32-0.33 where the anisotropy due to the electronic structure is small. With increasing doping the magnetic anisotropy changes from strong uniaxial anong the c axis (Kapprox. 2.5x10[sup 6] erg/cm[sup 3]) at x=0.3 to strong easy plane (Kapprox. -3.7x10[sup 6] erg/cm[sup 3]) at x=0.4 in an almost linear fashion. This evolution is explained through the change of the orbital nature of the e[sub g] electrons from predominantly d[sub 3z[sup 2]-r[sup 2]] to predominantly d[sub ! x[sup 2]-y[sup 2]]. On the samples displaying easy-plane anisotropy a small anisotropy in the basal plane of about -7x10[sup 4] erg/cm[sup 3] was determined with (110) being the easy axis. An estimate of the spin-wave gap based on these results is in reasonable agreement with experimental determinations. © 2001 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
2001
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