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Dust trapping in the global pressure bump induced by magnetospheric truncation offers a promising formation mechanism for close-in super-Earths/sub-Neptunes. These planets likely form in evolved protoplanetary discs, where the gas temperature at the expanding truncation radius become amiable to refractory solids. However, dust accumulation may alter the disc opacity such that thermal evolution is inevitable. To better understand how thermodynamics affects this planet formation pathway, we conduct a suite of local dust evolution simulations in an idealized inner disc model. Our calculations take into account self-consistent opacity-dependent temperature changes as well as dust evaporation and vapour condensation. We find that disc thermal evolution regulates dust growth and evolution, discouraging any accumulation of small particles that drives the increase of opacity and temperature. Significant retention of dust mass takes place when the disc environments allow runaway growth of large solids beyond the fragmentation barrier, where small particles are then swept up and preserved. Our results further validate dust accumulation near disc truncation as a promising mechanism to form close-in planets. [ABSTRACT FROM AUTHOR]

Cherries (subg. Cerasus) belong to Prunus s.l. (Rosaceae) and are widely distributed in temperate and subtropical regions of the Northern Hemisphere. Given its ornamental and edible functions, it is a hugely preferred germplasm resource for human societies. However, the interspecific phylogenetic relationships, divergence times, and routes of this subgenus remain unclear. To reveal its enigmatic and intricate evolutionary history, we newly sequenced 12 subg. Cerasus species, reconstructed the plastome phylogeny with 24 previously published subg. Cerasus species. This study supports that subg. Cerasus split into five clades, among which P. mahaleb is the basal group of subg. Cerasus ; P. campanulata is genetically distantly related to P. cerasoides and is not recommended for treatment as a variety of the latter; P. subhirtella is involved in the speciation of P. yedoensis. Molecular dating and ancestral area reconstructions infer that subg. Cerasus originated in the Eastern Mediterranean–Central Asia before 11.57 Mya (95% HPD = 5.34–19.1 Mya) and subsequently spread into the Qinghai-Tibetan Plateau (QTP) and adjacent regions. The first dispersal event of modern subg. Cerasus was facilitated by 'out-of-QTP', colonizing North America across the Bering Land Bridge and re-dispersing into Europe from the Late Miocene to Pliocene and forming the initial distribution pattern of extant subg. Cerasus in the Pliocene; The end of the Quaternary glacial period witnessed a second dispersal event, and core subg. Cerasus population diversity flourished radially in its separate refugia during the Late Pleistocene. [ABSTRACT FROM AUTHOR]

Background: Bilious vomiting in a child potentially portends the dire emergency of intestinal malrotation with volvulus, necessitating prompt surgical management, with differentials including small-bowel atresia, duodenal stenosis, annular pancreas, and intussusception. Although the upper-gastrointestinal series (UGI) is the diagnostic investigation of choice, up to 15% of the studies are inconclusive, thereby posing a diagnostic challenge. Case Reports: We report a case series of 3 children referred for bilious vomiting, whose initial UGI was inconclusive and who were eventually confirmed to have intestinal malrotation at surgery. The first child was a female born at 37 weeks with antenatally diagnosed situs inversus and levocardia, who developed bilious vomiting on day 1 of life. The duodenojejunal flexure (DJ) could not be visualized on the UGI because of faint opacification on first pass of the contrast and subsequent overlap with the proximal jejunal loops. The second child was a male born at 36 weeks, presenting at age 4 months with bilious vomiting of 2 days duration. The third child was a female born at 29 weeks, presenting with bilious aspirates on day 3 of life. UGI for all 3 showed persistent hold-up of contrast at the proximal duodenum with no opacification of the distal duodenum or small bowel. Adjunctive techniques during the UGI and ultrasound examination helped achieve a preoperative diagnosis of malrotation in these children. Conclusions: Application of diagnostic adjuncts to an inconclusive initial UGI may help elucidate a preoperative diagnosis of intestinal malrotation in infantile bilious vomiting. [ABSTRACT FROM AUTHOR]

Background/Aims: Plumbagin (PL) has been shown to effe ctively inhibit autophagy, suppressing invasion and migration of hepatocellular carcinoma (HCC) cells. However, the specific mechanism remains unclear. This study aimed to investigate the effect of PL on tumor growth factor (TGF)-ß-induced epithelial-mesenchymal transition (EMT) in HCC. Methods: Huh-7 cells were cultured, and in vivo models of EMT and HCC-associated lung metastasis were developed through tail vein and in situ injections of tumor cells. In vivo imaging and hematoxylin and eosin staining were used to evaluate HCC modeling and lung metastasis. After PL intervention, the expression levels of Snail, vimentin, E-cadherin, and N-cadherin in the liver were evaluated through immunohistochemistry and Western blot. An in vitro TGF-ß-induced cell EMT model was used to detect Snail, vimentin, E-cadherin, and N-cadherin mRNA levels through a polymerase chain reaction. Their protein levels were detected by immunofluorescence staining and Western blot. Results: In vivo experiments demonstrated that PL significantly reduced the expression of Snail, vimentin, and N-cadherin, while increasing the expression of E-cadherin at the protein levels, effectively inhibiting HCC and lung metastasis. In vitro experiments confirmed that PL up-regulated epithelial cell markers, down-regulated mesenchymal cell markers, and inhibited EMT levels in HCC cells. Conclusion: PL inhibits Snail expression, up-regulates E-cadherin expression, and down-regulates N-cadherin and vimentin expression, preventing EMT in HCC cells and reducing lung metastasis. [ABSTRACT FROM AUTHOR]

By performing global hydrodynamical simulations of accretion discs with driven turbulence models, we demonstrate that elevated levels of turbulence induce highly stochastic migration torques on low-mass companions embedded in these discs. This scenario applies to planets migrating within gravito-turbulent regions of protoplanetary discs as well as stars and black holes embedded in the outskirts of active galactic nucleus (AGN) accretion discs. When the turbulence level is low, linear Lindblad torque persists in the background of stochastic forces and its accumulative effect can still dominate over relatively long time-scales. However, in the presence of very stronger turbulence, classical flow patterns around the companion embedded in the disc are disrupted, leading to significant deviations from the expectations of classical Type I migration theory over arbitrarily long time-scales. Our findings suggest that the stochastic nature of turbulent migration can prevent low-mass companions from monotonically settling into universal migration traps within the traditional laminar disc framework, thus reducing the frequency of three-body interactions and hierarchical mergers compared to previously expected. We propose a scaling for the transition mass ratio from classical to chaotic migration q  ∝ αR, where αR is the Reynolds viscosity stress parameter, which can be further tested and refined by conducting extensive simulations over the relevant parameter space. [ABSTRACT FROM AUTHOR]