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8,222 results on '"Yazawa, K."'

202. NEITHER COMPLEMENT INHIBITION NOR DEPLETION OF NATURAL ANTIBODY IS REQUIRED TO AVOID HYPERACUTE OR ACCELERATED ACUTE REJECTION FOLLOWING GALT-KO PIG-TO-BABOON RENAL TRANSPLANTATION

Author

Yazawa, K, primary, Hisashi, Y, additional, Shimizu, A, additional, O’Malley, P, additional, Nuhn, M, additional, Moran, S, additional, Nobori, S, additional, Vagefi, P A., additional, Buhler, L, additional, Cooper, D K.C., additional, Hawley, R, additional, Schuurman, H-J, additional, Greenstein, J, additional, Sachs, D H., additional, and Yamada, K, additional

Published
2004
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203. UNDETECTABLE LEVELS OF GAL-ALPHA-1,3-GAL EXPRESSION ARE REQUIRED TO AVOID HYPERACUTE OR ACCELERATED ACUTE REJECTION IN PIG-TO-BABOON RENAL TRANSPLANTATION

Author

Yazawa, K, primary, Shimizu, A, additional, Hisashi, Y, additional, Nuhn, M, additional, Nobori, S, additional, Moran, S, additional, O’Malley, P, additional, Cooper, D K.C., additional, Hawley, R, additional, Shuurman, H J., additional, Greenstein, J, additional, Sachs, D H., additional, and Yamada, K, additional

Published
2004
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204. CO-TRANSPLANTING A VASCULARIZED DONOR THYMIC GRAFT AND LIFE-SUPPORTING KIDNEY USING GALT-KO DONORS IN BABOONS

Author

Yamada, K, primary, Yazawa, K, additional, Shimizu, A, additional, Nuhn, M, additional, Moran, S, additional, Hisashi, Y, additional, Nobori, S, additional, Fishman, J, additional, Cooper, D K.C., additional, Hawley, R, additional, Patience, C, additional, Greenstein, J, additional, Schuurman, H, additional, Sykes, M, additional, and Sachs, D H., additional

Published
2004
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214. The postantifungal effect of 5-fluorocytosine on Candida albicans.

Author

Scalarone, Gene M., Mikami, Yuzuru, Kurita, Nobuyuki, Yazawa, Katsukiyo, Miyaji, Makoto, Scalarone, G M, Mikami, Y, Kurita, N, Yazawa, K, and Miyaji, M

Abstract

The in-vitro postantifungal effect (PAFE) of 5-fluorocytosine for for short periods of time was investigated. Yeast cells were exposed for 0·5,1 or 2 h to a range of concentrations (0·1–3·2 mg/L) of 5-fluorocytosine. The PAFE was quantitated by determinations of the number of colony forming units at hourly intervals (0–10 h) after removal of the drug by dilution. The length of the PAFE was dependent upon the concentration of 5-fluorocytosine and the duration of exposure. An exposure time of 0·5 h resulted in PAFE's ranging from 0 to 4·2 h. Exposure times of 1 and 2 h resulted in longer PAFEs and in many instances suppression of cell growth was seen for the entire evaluation period (up to ten hours). [ABSTRACT FROM PUBLISHER]

Published
1992

215. In-vitro activity of flomoxef, a new oxacephem group antibiotic, against Nocardia in comparison with other cephalosporins.

Author

Yazawa, Katsukiyo, Mikami, Yuzuru, Uno, Jun, Otozai, Kiyotaka, Arai, Tadashi, Yazawa, K, Mikami, Y, Uno, J, Otozai, K, and Arai, T

Abstract

The susceptibility of 113 strains of pathogenic Nocardia, N. asteroides, N. farcinica, N. nova, N. brasiliensis and N. otitidiscaviarum to a new oxacephem antibiotic flomoxef was determined by an agar dilution method in comparison with those of 13 other cephalosporins. Flomoxef was two to 50 times more active against these pathogenic Nocardia than other cephalopsorins tested. However, there were differences in susceptibility to this antibiotic among these Nocardia strains. N. asteroides was the most sensitive species, followed by N. farcinica and N. nova. N. brasiliensis was moderately sensitive and N. otitidiscaviarum was resistant. [ABSTRACT FROM AUTHOR]

Published
1989

220. Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA).

Author

Takahashi, M, Totsuka, Y, Masuda, M, Fukuda, K, Oguri, A, Yazawa, K, Sugimura, T, and Wakabayashi, K

Abstract

Docosahexaenoic acid (DHA), a major component of fish oil, suppresses the formation and growth of aberrant crypt foci induced by 1,2-dimethylhydrazine and azoxymethane. In the present study we examined the effects of intragastric gavage administration of DHA on the yield of rat colonic aberrant crypt foci due to treatment with a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), which induces colon cancer in male F344 rats and is considered to be a possible human colon carcinogen. Male F344 rats were given a standard diet (AIN-76A) and received 10 doses of PhIP (75 mg/kg body wt, by intragastric intubation, on days 1-5 and 8-12) with or without intragastric application of 1 ml DHA 4 h prior to each carcinogen treatment, followed by further DHA dosing. The numbers of PhIP-induced aberrant crypt foci per colon after 4 and 12 weeks DHA administration were significantly reduced to 47 and 38% respectively of the values obtained when PhIP alone was used. The mean number of aberrant crypts per focus was also decreased by DHA treatment. At week 4 the PhIP-DNA adduct levels in the colon of rats from the PhIP+DHA group were approximately two thirds of the PhIP group value. The results thus suggest that DHA exerts a preventive effect on PhIP-induced colon carcinogenesis. [ABSTRACT FROM PUBLISHER]

Published
1997
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221. Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA).

Author

Takahashi, M, Fukutake, M, Isoi, T, Fukuda, K, Sato, H, Yazawa, K, Sugimura, T, and Wakabayashi, K

Abstract

The effects of intragastric gavage administration of docosahexaenoic acid (DNA) , a major component of fish oil, on azoxymethane (AOM)-induced colon carcinogenesis in rats was investigated. Male F344 rats were treated with 15 mg/kg body wt of AOM once a week, for two weeks. The animals were given either 1 ml of DHA or water intragastrically 5 times a week, starting the day before the first carcinogen treatment. The numbers of AOM-induced aberrant crypt foci in the rats given DHA were 76% and 62% of the control values, at 4 and 12 weeks, respectively. After 36 weeks of DHA treatment, colon tumors were counted and examined histologically. The blood plasma levels of prostaglandin E2 (PGE2) and polyunsaturated fatty acids were also quantified. The incidences of colon cancer did not differ, being 96% and 92% in the AOM and AOM+DHA groups, respectively. Colon cancer multiplicity was, however, significantly decreased by the DHA treatment; 3.65 +/- 2.18 in the AOM group and 2.41 +/- 1.58 in the AOM+DHA group (P <0.01). Notably, the numbers of moderately differentiated adenocarcinomas in the middle and distal colon in the DHA-treated group were lower than in the AOM group. The levels of PGE2 and arachidonic acid in the blood plasma of DHA-treated rats were also significantly lower than in the AOM group. These results suggest that DHA exerts its inhibitory effect on colon carcinogenesis by modulating lipid metabolism and inhibiting the arachidonic cascade. [ABSTRACT FROM PUBLISHER]

Published
1997
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230. Positive effects of kidney transplantation on bone mass

Author

Yazawa, K, primary, Ishikawa, T, additional, Ichikawa, Y, additional, Shin, J, additional, Usui, Y, additional, Hanafusa, T, additional, Fukunishi, T, additional, Sakai, R, additional, Nagano, S, additional, Fujita, N, additional, and Mizuno, K, additional

Published
1998
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