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4,196 results on '"Yao Jing"'

217. Evaluation of the safety and efficacy of a novel Anatomical classification and dUal anchoRing theory to Optimize the tavR strategy for pure severe Aortic regurgitation (AURORA): a prospective cohort study

Author

Yao, Jing, Lu, Zhi-Nan, Modine, Thomas, Jilaihawi, Hasan, Piazza, Nicolo, Tang, Yi-Da, Xu, Ji-Zhe, Peng, Xiao-Ping, Wang, Hai-Ping, Li, Chuan-Bao, Chen, Hui, Liu, Chang-Fu, Jiang, Zheng-Ming, Li, Jie, Yu, Fei-Cheng, Han, Ke, Wang, Sheng, Huang, Hui, and Song, Guang-Yuan

Published
2022
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229. In vivo and in vitro chemical composition and biological activity of traditional vs. dispensing granule decoctions of Coptidis Rhizoma: A comparative study.

Author

Wang, Panpan, Gui, Xinjing, Xu, Manwen, Dong, Fengyu, Li, Yuanyuan, Wang, Qi, Wang, Yanli, Yao, Jing, Lu, Lu, and Liu, Ruixin

Abstract

Coptidis Rhizoma (CR) holds significant clinical importance. In this study, we conducted a comparative analysis of CR's dispensing granule decoction (DGD) and traditional decoction (TD) to establish a comprehensive evaluation method for the quality of DGD. We selected nine batches of DGD (three from each of manufacturers A, B and C) and 10 batches of decoction pieces for analysis. We determined the content of representative components using high‐performance liquid chromatography and assessed the content of blood components in vivo post‐administration using ultra‐performance liquid chromatography–mass spectrometry. The antibacterial activity was measured using the drug‐sensitive tablet method. To evaluate the overall consistency of DGD and TD, we employed the CRITIC method and Grey relational analysis method. Our CRITIC results indicated no significant difference between the CRITIC scores of DGD‐B and TD, with DGD‐B exhibiting the highest consistency and overall quality. However, DGD‐A and DGD‐C showed variations in CRITIC scores compared with TD. After equivalent correction, the quality of DGD‐A and DGD‐C approached that of TD. Furthermore, our Grey relational analysis results supported the findings of the CRITIC method. This study offers a novel approach to evaluate the consistency between DGD and TD, providing insights into improving the quality of DGD. [ABSTRACT FROM AUTHOR]

Published
2024
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230. Development of a Two-Dimensional Liquid Chromatography Online Deproteinization Method for Determining Paclitaxel-Related Substances in a Paclitaxel Injection (Albumin-Bound).

Author

Yao, Jing, Zhao, Xuejia, Jiang, Yifei, Zuo, Limin, Qiu, Xiaodan, Lian, Xiaofang, Liu, Huiyi, Jia, Qingying, Sun, Huimin, and Shan, Guangzhi

Subjects
*HIGH performance liquid chromatography, *LIQUID chromatography, *LIQUID analysis, *PACLITAXEL, *POWER resources, *SOLID phase extraction
Abstract

To determine the paclitaxel-related substances in a paclitaxel injection (albumin-bound), it is necessary to remove human blood albumin from the sample via solid-phase extraction and subsequently perform high-performance liquid chromatography analysis. The pre-processing operation is complicated, the duration of analysis is long, and much human power and material resources are needed in the sample testing process. Thus, the purpose of this study was to develop a quick two-dimensional liquid chromatography method that requires less consumables and possesses high sensitivity. Samples were directly injected into one-dimensional solid-phase extraction columns to remove human blood albumin. Paclitaxel and its related substances in the solid-phase extraction columns were then eluted into two-dimensional analytical columns through valve switching technology. The sample pretreatment step can be omitted in this method, which allows for the analysis of paclitaxel and its related substances to be completed more quickly, within only 15 min, under the developed two-dimensional elution conditions. The established method had good linearity (R2 = 0.9994), limit of detection (0.25 μg·mL−1), limit of quantification (0.5 μg·mL−1), precision (RSD = 0.5%), and accuracy (102.53–107.97%). [ABSTRACT FROM AUTHOR]

Published
2024
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