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UNC51-like kinase1 (ULK1) recruits its binding partners and initiates the autophagy process in cancer. ULK1 is significantly overexpressed in Non-small cell lung cancer (NSCLC) and negatively correlated with clinical prognosis in NSCLC patients. Based upon the binding features of ULK1, we explored the pharmacophore modeling to discover the common anchoring features. It was verified by synthesizing 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives, as well as subsequently elucidating the structure-activity relationships (SAR). Among all the obtained ULK1 inhibitors, 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine (3s), was the most active one. The docking analysis was conducted to compare 3s and SBI-0206965, which further elucidated the roles of the H-bond donor. This compound inhibited the proliferation of A549 cells and showed strong inhibitory activity against ULK1 kinase. Moreover, we found that compound 3s could induce apoptosis while simultaneously blocking autophagy. Collectively, these findings shed new light on compound 3s that would be utilized as a promising candidate drug for the future NSCLC therapy.

Due to the fact that HI mass measurements are not available for large galaxy samples at high redshifts, we apply a photometric estimator of the HI-to-stellar mass ratio (M_HI/M_*) calibrated using a local Universe sample of galaxies to a sample of galaxies at z ~ 1 in the DEEP2 survey. We use these HI mass estimates to calculate HI mass functions (HIMFs) and cosmic HI mass densities (Omega_HI), and to examine the correlation between star formation rate and HI gas content, for galaxies at z ~ 1. We have estimated HI gas masses for ~ 7,000 galaxies in the DEEP2 survey with redshifts in the range 0.75 < z < 1.4 and stellar masses M_* > 10^{10} M_solar, using a combination of the rest-frame ultraviolet-optical colour (NUV - r) and stellar mass density (mu_*) as a way to estimate M_HI/M_*. It is found that the high mass end of high-z HI mass function (HIMF) is quite similar to that of the local HIMF. The lower limit of Omega_HI,limit = 2.1 * 10^{-4} h_70^{-1}, obtained by directly integrating the HI mass of galaxies with M_* > 10^{10} M_solar, confirms that massive star-forming galaxies do not dominate the neutral gas at z ~ 1. We study the evolution of the HI mass to stellar mass ratio from z ~ 1 to today and find a steeper relation between HI gas mass fraction and stellar mass at higher redshifts. Specifically, galaxies with M_* = 10^{11} M_solar at z ~ 1 are found to have 3 - 4 times higher neutral gas fractions than local galaxies, while the increase is as high as 4 - 12 times at M_* = 10^{10} M_solar. The quantity M_HI/SFR exhibits very large scatter, and the scatter increases from a factor of 5 - 7 at z = 0 to factors close to a hundred at z = 1. This implies that there is no relation between HI gas and star formation in high redshift galaxies. The HI gas must be linked to cosmological gas accretion processes at high redshifts., 10 pages, 13 figures, A&A accepted

Changing-look Active Galactic Nuclei (CL-AGNs) are a subset of AGNs in which the broad Balmer emission lines appear or disappear within a few years. We use the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey to identify five CL-AGNs. The 2-D photometric and kinematic maps reveal common features as well as some unusual properties of CL-AGN hosts as compared to the AGN hosts in general. All MaNGA CL-AGNs reside in the star-forming main sequence, similar to MaNGA non-changing-look AGNs (NCL-AGNs). The $80\% \pm 16\%$ of our CL-AGNs do possess pseudo-bulge features, and follow the overall NCL-AGNs $M_{BH}-\sigma_{*}$ relationship. The kinematic measurements indicate that they have similar distributions in the plane of angular momentum versus galaxy ellipticity. MaNGA CL-AGNs however show a higher, but not statistically significant ($20\% \pm 16\%$) fraction of counter-rotating features compared to that ($1.84\% \pm 0.61\%$) in general star-formation population. In addition, MaNGA CL-AGNs favor more face-on (axis ratio $>$ 0.7) than that of Type I NCL-AGNs. These results suggest that host galaxies could play a role in the CL-AGN phenomenon., Comment: 11 pages, 4 tables, 4 figures. Accepted for publication in MNRAS

Serotonin (5-hydroxytraptamine, 5-HT) is a neurotransmitter plays important roles in emotion and motivation. The action of 5-HT varies across nucleus and the receptor sub-types. Lateral habenula (LHb) in a brain area reciprocally connects with raphe nucleus and plays important roles in emotion and depression. In this study, we aimed to study the role of 5-HT1 receptor in LHb on fear learning. 15 minutes before or immediate after the fear conditioning, 5-Carboxyamidotrypamine maleate salt (5-CT), an agonist of 5-HT1 receptor, was bilaterally delivered into LHb (1μg/μl, 1μl/side) in rats. We found that activation of 5-HT1 receptor in LHb impaired the acquisition but not consolidation of fear memory in rats, which was accompanied by impaired long-term potentiation (LTP) and decreased phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subunit 1 (GluA1) at the Ser845 site in hippocampus. In addition, 5-CT decreased the time spent in center area of the open field and time spent in open arm in elevated plus maze. These results suggest that activation of 5-HT1 receptor in LHb impaired acquisition of hippocampal dependent fear memory and increased anxiety- like behavior in rats.

With the rapid development of cancer-targeted nanotechnology, a variety of nanoparticle-based drug delivery systems have clinically been employed in cancer therapy. However, multidrug resistance significantly impacts the therapeutic efficacy. Physical non-drug therapy has emerged as a new and promising strategy. This study aimed to determine whether novel folate-nanobubbles (F-NBs), combined with therapeutic ultrasound (US), could act as a safe and effective physical targeted cancer therapy. Using folate-conjugated N-palmitoyl chitosan (F-PLCS), we developed novel F-NBs and characterised their physicochemical properties, internalization mechanism, targeting ability, therapeutic effects, and killing mechanism. The results showed that the novel F-NBs selectively accumulated in FR-positive endothelial cells and tumour cells via FR coupled with clathrin- and caveolin-mediated endocytosis in vitro and in vivo. In addition, the F-NBs killed target cells by an intracellular explosion under US irradiation. Hoechst/PI staining demonstrated that apoptosis and necrosis accounted for a large proportion of cell death in vivo. F-NBs combined with US therapy significantly inhibited tumour growth and improved the overall survival of tumour-bearing mice. Under US irradiation, the novel F-NBs selectively killed FR-positive tumour cells in vitro and in vivo via intracellular explosion and therefore is a promising alternative for targeted cancer treatment.

Bacterial blight (BB) caused by Xanthomonas axonopodis pv. dieffenbachiae (Xad) is the most destructive disease of ornamental anthurium. In the present study, foliar resistance of 21 anthurium cultivars were assessed under shaded field and laboratory conditions by injection inoculation of 3 × 108 cfu/ml Xad; disease severity was evaluated using a pretransformed rating scale after symptoms survey. Then six selected cultivars with different resistance levels were evaluated for the induced activities of six defence-related enzymes. The obtained results indicated that the same cultivar shared identical resistance under both conditions, but there was a great variation among the cultivars. Anthurium cv. Pink Champion and Manaka showed the highest resistance, and five other cultivars were highly susceptible. The activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) in the resistant cultivars increased much faster and reached much higher peak levels than those in susceptible cultivars. Further analyses revealed that the relative resistance index (RRI) significantly positively correlated with the activities of SOD, APX, POD and PAL, but not with catalase (CAT) and polyphenol oxidase (PPO), suggesting that early rapid accumulation of SOD, APX, PAL and POD might be an important mechanism of defence against Xad and could serve as one of the valuable physiological indices for the prediction of BB resistance in anthurium germplasm. Consequently, the identified resistant cultivars and the induced defence enzymes will facilitate the phytopathological research and enhance blight resistance selection in future breeding.

Laplacian Eigenmaps is a popular nonlinear dimensionality reduction technique and there exist various scenarios of its extensions. In this paper, a semi-supervised rough fuzzy Laplacian Eigenmaps (SSRFLE) approach is developed for dimensionality reduction of high dimensional hybrid data. In the proposed method, a set of semi-supervised fuzzy similarity granules are constructed to characterize the similarity between samples according to the principle that homogeneous samples have higher similarity degrees than heterogeneous samples. A neighborhood rough fuzzy set model of such fuzzy similarity granules is built to assess the degrees two samples belong to the same class. A Laplacian nearest neighborhood graph and a class-related neighborhood graph are constructed to characterize the topological structure between samples and between each sample and its prototype to ensure homogeneous samples being mapped closer to and more compact around the prototypes in a lower dimensional space. In view of the fact that different features bring out distinct impacts on performances of feature extraction and clustering, the significance of each feature is assessed by designing an information entropy measure and the weighted distance between samples is incorporated into the proposed technique. A series of simulation experiments on real world hybrid datasets are carried out. Experimental results show superior performance of the proposed method in classification accuracy and data visualization compared with other state of the art semi-supervised methods.

The Lossen rearrangement is a classic process for transforming activated hydroxamic acids into isocyanate under basic or thermal conditions. In the current report we disclosed a consecutive Lossen rearrangement/transamidation reaction in which unactivated hydroxamic acids were converted into N-substituted formamides in a one-pot manner under catalyst- and additive-free conditions. One feature of this novel transformation is that the formamide plays triple roles in the reaction by acting as a readily available solvent, a promoter for additive-free Lossen rearrangement, and a source of the formyl group in the final products. Acyl groups other than formyl could also be introduced into the product when changing the solvent to other low molecular weight aliphatic amide derivatives. The solvent-promoted Lossen rearrangement was better understood by DFT calculations, and the intermediacy of isocyanate and amine was supported well by experiments, in which the desired products were obtained in excellent yields under similar conditions. Not only monosubstituted formamides were synthesized from hydroxamic acids, but also N,N-disubstituted formamides were obtained when secondary amines were used as precursors.

A new amphiphilic organoplatinum(ii) metallaclip was designed and fabricated successfully through coordination driven self-assembly. It can further self-assemble into multi-dimensional well-defined micro-structures with different CH3OH/H2O ratios, and show enhanced fluorescence emission in water.

Based on the cascade utilization of high-temperature waste heat and selective non-catalytic reduction (SNCR) technology, a new-type coke oven regenerator with ammonia injection space was proposed. By changing the structure and operating parameters, the high-temperature heat storage and NO emission reduction are achieved synergistically. A three-dimensional model was used to study the flow, heat transfer, and SNCR process inside the regenerator. The validity of the model was verified. Results showed that the new-type regenerator had a significant cascade utilization characteristics of waste heat. There was a competitive reaction between NH3 + NO → N2 and NH3 → NO during the coupled SNCR process. The optimal reaction temperature window was 911 ~ 984°C, and the residence time was 0.21 ~ 0.38 s. The mixing of the reductant with the flue gas and the complete contact of NH3 with NO determined high NO reduction efficiency. Furthermore, combining multiple operating parameters, a strategy was proposed to ensure the outlet NO/NH3 concentration meets the emission standard requirements.

Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopamine receptor agonists (apomorphine 0.05 mg/kg; SKF38393 0.01 mg/kg; bromocriptine 0.05 mg/kg), which have no effects on spatial recognition memory, were injected intraperitoneally into mice 30 minutes before a memory test in a two-trial recognition Y-maze. The Y-maze is based on the innate tendency of rodents to explore novel environments and is therefore suitable for exploring the effects of morphine on learning and memory. Our results showed that both D1-like and D2-like dopamine receptor agonists dose-dependently impaired the retrieval of spatial recognition memory in the Y-maze, and co-administration of memory ineffective doses of apomorphine (0.05 mg/kg), SKF38393 (0.01 mg/kg), or bromocriptine (0.05 mg/kg) and of morphine (2.5 mg/kg) resulted in impaired spatial recognition memory retrieval in mice. These findings suggest the existence of interactions between morphine and dopamine receptor agonists in memory processing and that activation of the dopamine system might contribute to morphine-induced impairment of memory, which could provide insight into human addiction.

The conversion of ≡Fe(III) to ≡Fe(II) in the heterogeneous Fenton is low efficient to enhance catalytic activity. Biogenic schwertmannite (Sch), as an iron-based catalyst, is usually formed via Fe(II) oxidation mediated by Acidithiobacillus ferrooxidans (A. ferrooxidans), and contains low organic carbon mainly originated from exopolymeric substances. Owing to the magnetic inter-attraction between A. ferrooxidans and Fe3O4, the introduction of strong magnetic Fe3O4 during synthesis process of biogenic Sch can modify more organic carbon in Sch-based catalyst. Surprisingly, Fe3O4-loaded Sch with organic carbon (Fe3O4/Sch/C) exhibits much higher activity for fluoroquinolone antibiotics degradation than Sch, Fe3O4, and Fe3O4-loaded Sch without organic carbon, which is mainly ascribed to more electrons provided by organic carbons for promoting ≡Fe(II) generation in heterogeneous Fenton. This finding not only provides an ecofriendly, cost-effective, and efficient catalyst, but also gives a new sights into the potential application of iron oxyhydroxysulfate with green carbon-source for contaminants removal.

Three new diterpenoid alkaloids (1–3), and eight known alkaloids (4–11) were isolated from the aerial parts of Delphinium grandiflorum. Grandifline A (1) represents an unprecedented diterpenoid alkaloid ring system featuring a C-7 N C 17 hemiaminal moiety and a lactone fragment through the linkage of C-17 O C 19 unit. And we named this newly-discovered class of rearranged C19-diterpenoid alkaloid scaffold as grandiflodines (B-12). Grandifline B (2) is the first naturally-occurring 7,17-secolycoctonine diterpenoid alkaloid with a C-7 O C 17 unit forming a hemiacetal. Their structures were elucidated via spectroscopic data and single-crystal X-ray diffraction analysis. The protective effects of compounds 1–11 on H2O2-induced cardiomyocytes injury were assayed. And compounds 6 and 10 showed significant protective effects, with IC50 values of 1.881 ± 0.680 μM and 1.904 ± 0.750 μM, respectively. Further, compound 6 could reduce oxidative damage by inhibiting cell death via the AMPK/AKT/mTOR signaling pathway in H2O2-induced H9C2 cells.

// Meisheng Zou 1,2,* , Chixiong Huang 1,* , Xinzhong Li 1 , Xiang He 1 , Yanmei Chen 1 , Wangjun Liao 3 , Yulin Liao 1 , Jie Sun 1,4 , Ze Liu 2 , Lintao Zhong 1 and Jianping Bin 1 1 Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China 2 Wards of Cadres, Guangzhou General Hospital of Guangzhou Military Region, Guangzhou, China 3 Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China 4 Department of Cardiology, Zhongshan Hospital, Sun Yat-Sen University, Zhongshan, China * These authors have contributed equally to this work Correspondence to: Jianping Bin, email: // Lintao Zhong, email: // Keywords : thoracic aortic dissection, circular RNA, microarray, biomathematics, Pathology Section Received : February 12, 2017 Accepted : June 18, 2017 Published : July 05, 2017 Abstract Objective: To assess the circular RNAs (circRNAs) expression profile and explore the potential functions in human thoracic aortic dissection (TAD). Methods: The differentially expressed circRNAs profiles of the aortic segments between human type A TAD patients ( n =3) and age-matched normal donors (NA; n =3) were analyzed using the Arraystar human circRNAs microarray. Quantitative real-time PCR was used to validate the expression pattern of circRNAs, parental genes, and hsa-miR-320a; Western blotting confirmed MMP9 expression with additional samples. Bioinformatic tools including network analysis, Gene ontology, and KEGG pathway analysis were utilized. Results: Among 8,173 detected circRNA genes, 156 upregulated and 106 downregulated significantly in human TAD as compared to NA (P£0.05). Quantitative real-time PCR showed an elevated expression of the upregulated hsa_circRNA_101238, hsa_circRNA_104634, hsa_circRNA_002271, hsa_circRNA_102771, hsa_circRNA_104349, COL1A1, and COL6A3 and reduced of the downregulated hsa_circRNA_102683, hsa_circRNA_005525, hsa_circRNA_103458, and FLNA. Gene ontology analysis revealed that the parental genes favored several pathological processes, such as negative regulation of cell proliferation and extracellular matrix organization. The circRNA-miRNA co-expression network predicted that 33 circRNAs might interact with at least one target miRNAs altered in TAD. KEGG pathway analysis revealed that 28 altered miRNAs were enriched on focal adhesion and vascular smooth muscle contraction. The hsa_circRNA_101238-miRNA-mRNA network indicated the highest degree of hsa-miR-320a. Quantitative real-time PCR and Western blot manifested the low expression of hsa-miR-320a and high of MMP9 in human TAD tissues, respectively. Conclusions: This study revealed hundreds of differentially expressed circular RNAs in human TAD, suggesting that hsa_circRNA_101238 might inhibit the expression of hsa-miR-320a and increase that of MMP9 in TAD.

With the flourish development of computer vision technology, hand gesture recognition plays a more and more vital role in human-computer interaction for its convenient and nonverbal communication. However, confusion caused by similar gestures brings inherent errors when considering enough meaningful gestures in the database. In this paper, an automatic feature extraction for similar gesture recognition is proposed with respect to confusion arising in similar gestures. Except the orientation feature, four additional innovative features are extracted to distinguish all the similar gestures remarkably in the experimental database containing 10 numbers and 26 letters. Compared with the conventional method that a couple of similar gestures are extracted as a specific feature, the proposed method distinguishes similar gestures with automatic distinctive feature extraction. Experimental results show high recognition rate and versatility of the proposed method.

Advanced maternal or paternal age is associated with increased risks of cognitive and emotional disorders. Chronic stress is also a common experience in human life that causes psychiatric diseases. However, the synergistic effects of these two factors on offspring are rarely studied. In the present study, the offspring of both young (3-4 months) and old (12-14 months) rat parents were given CUMS for 21 days at the age of 4 weeks. The effects of advanced parental age and chronic unpredictable mild stress (CUMS) on emotional and cognitive behaviors and the related cellular mechanisms were investigated by using behavioral and electrophysiological techniques. We found that CUMS decreased sucrose consumption, increased anxiety, and impaired learning and memory in offspring from both old and young breeders. However, advanced parental age impaired fear memory and spatial memory mainly in female offspring. The serum corticosterone of female offspring was lower than males, but advanced parental age significantly elevated serum corticosterone in female offspring in response to electrical foot shocks. In addition, hippocampal LTD was severely impaired in female offspring from older parents. Our results indicated that female offspring from older breeders might be more sensitive to stress, and the hippocampal function was more vulnerable. These results might provide experimental basis for the prevention and treatment of advanced parental age related psychiatric disorders in future.

Galactic outflows are believed to play an important role in regulating star formation in galaxies, but estimates of the outflowing mass and momentum have historically been based on uncertain assumptions. Here, we measure the mass, momentum, and energy outflow rates of seven nearby star-forming galaxies using ultraviolet absorption lines and observationally motivated estimates for the density, metallicity, and radius of the outflow. Low-mass galaxies generate outflows faster than their escape velocities with mass outflow rates up to twenty times larger than their star formation rates. These outflows from low-mass galaxies also have momenta larger than provided from supernovae alone, indicating that multiple momentum sources drive these outflows. Only 1-20\% of the supernovae energy is converted into kinetic energy, and this fraction decreases with increasing stellar mass such that low-mass galaxies drive more efficient outflows. We find scaling relations between the outflows and the stellar mass of their host galaxies (M$_\ast$) at the 2-3$\sigma$ significance level. The mass-loading factor, or the mass outflow rate divided by the star formation rate, scales as M$_\ast^{-0.4}$ and with the circular velocity as v$_\mathrm{circ}^{-1.6}$. The scaling of the mass-loading factor is similar to recent simulations, but the observations are a factor of five smaller, possibly indicating that there is a substantial amount of unprobed gas in a different ionization phase. The outflow momenta are consistent with a model where star formation drives the outflow while gravity counteracts this acceleration., Comment: 10 pages, 5 figures. Accepted for publication in MNRAS

The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals.

Background The impact of remote ischaemic preconditioning (RIPC) on major clinical outcomes in patients undergoing cardiovascular surgery remains controversial. We systematically reviewed the available evidence to evaluate the potential benefits of RIPC in such patients. Methods PubMed, Embase, and Cochrane Library databases were searched for relevant randomised controlled trials (RCTs) conducted between January 2006 and March 2016. The pooled population of patients who underwent cardiovascular surgery was divided into the RIPC and control groups. Trial sequential analysis was applied to judge data reliability. The pooled relative risks (RRs) with 95% confidence intervals (CIs) between the groups were calculated for all-cause mortality, major adverse cardiovascular and cerebral events (MACCEs), myocardial infarction (MI), and renal failure. Results RIPC was not associated with improvement in all-cause mortality (RR, 1.04; 95%CI, 0.82–1.31; I 2 =26%; P>0.05) or MACCE incidence (RR, 0.90; 95%CI, 0.71–1.14; I 2 =40%; P>0.05) after cardiovascular surgery, and both results were assessed by trial sequential analysis as sufficient and conclusive. Nevertheless, RIPC was associated with a significantly lower incidence of MI (RR, 0.87; 95%CI, 0.76–1.00; I 2 =13%; P≤0.05). However, after excluding a study that had a high contribution to heterogeneity, RIPC was associated with increased rates of renal failure (RR, 1.53; 95%CI, 1.12–2.10; I 2 =5%; P≤0.05). Conclusions In patients undergoing cardiovascular surgery, RIPC reduced the risk for postoperative MI, but not that for MACCEs or all-cause mortality, a discrepancy likely related to the higher rate of renal failure associated with RIPC.

In carbonylation of ethylene glycol to ethylene carbonate with urea catalyzed by ZnO, which was considered as a heterogeneous catalyst. ZnO is observed to be dissolved in the reactants probably due to the formation of Zn(NCO) 2 (NH 3 ) 2 making the reaction homogeneously catalyzed. To our knowledge, it is firstly reported that the reaction experienced three states including ZnO dissolution, homogeneous catalysis, and precipitate formation. The precipitate was characterized to be a mixture containing Zn(OH) 2 , ZnCO 3 , and Zn(NCO) 2 with a ratio of 8.5:6.1:1. Possible mechanisms of ZnO dissolution and precipitation were proposed.

Thinning algorithms often cause stroke distortions at the crosses or intersections of strokes, which lead to bad results in pattern recognition tasks. In order to overcome these drawbacks, this paper proposes a parallel thinning algorithm based on stroke continuity detection. In the algorithm, before it uses the conditions of parallel algorithms to delete a boundary point, it first detects whether the boundary point is a reserved point to keep stroke’s continuity or not. Consequently, it can produce a skeleton with good symmetry, control the large deformation at the cross or intersection of strokes, and make a better skeleton more quickly. Moreover, it is practically immune to noise.

In this work, we present the effects of high pressure on the structure and stability of cesium azide (CsN3) with the pressure up to ∼30.0 GPa, as studied by Raman and IR spectroscopy. Three phase transitions of Phase II → III → IV → V were revealed at ∼0.5, ∼3.7, and ∼16.0 GPa. The abnormal softening behavior of T(Eg) mode reveals the shearing distortion during Phase II → III transition. Moreover, changes of lattice modes and splitting of the degenerate T(Eg) and R(Eg) modes in Phase III indicate the breaking of crystallographically equivalent condition of azide ions. Phase IV was found to possess the C2/m structure, and Phase V has a lower symmetry structure than other phases. The IR measurements show the evolution of the N═N═N bending modes and the IR-active behavior of the symmetric stretch ν1 mode under pressure, which collectively reveal the rotation and bending of the azide ions upon compression. The azide ions groups were found to further bend under pressure, and the bent azide ions might enhance p...

We have reported the high-pressure behavior of 4-acetamidobenzenesulfonyl azide (C8H8N4O3S, 4-ABSA) by in situ Raman scattering, IR absorption, and synchrotron angle-dispersive X-ray diffraction (ADXRD) measurements in diamond anvil cells with the pressure up to ∼13 GPa at room temperature. All of the fundamental vibrational modes of 4-ABSA at ambient pressure were analyzed by combination of experimental measurements and theoretical calculations using the density functional theory method. Detailed Raman and IR spectroscopic analyses reveal two phase transitions in the pressure region of 0.8–2 and 4.2 GPa, respectively, which are confirmed by the changes in the ADXRD patterns. The first phase transition in the pressure region of 0.8–2 GPa is attributed to the ring distortion and the rotation of CH3 group, whereas the second phase transition at 4.2 GPa might be induced by the rearrangement of azide group and hydrogen bonds. The analyses of the N3 vibrational modes suggest that the bent azide group rotates p...

To test the performance of direct chemiluminescence immunoassay(CLIA) in the determination of serum 25-hydroxyvitamin D [25(OH)D] concentration.The CLIA analyzer of Italy DiaSorin was used to measure the 25(OH)D concentrations in the Standard Reference Material 972 a of National Institute of Standards and Technology, DiaSorin control materials, blind samples of Vitamin D External Quality Assessment Scheme(DEAQS), and outpatient serum samples. The functional sensitivity, precision, accuracy, recovery, and linearity were evaluated, and the samples of mild hemolysis, 5 days' storage at 4 ₿ and1 year's storage at-80 ₿were tested for 25(OH)D.The functional sensitivity was4 ng/mL. The coefficient of variations of intra-and inter batch were8. 1%. The relative deviation was-3. 1%-5. 7%. The recovery rates were 82. 8%-112. 9% and it had good linearity in the range of 7. 6-128. 1 ng/mL. Compared with fresh serum, the serum 25(OH)D concentration was not affected by mild hemolysis or being stored at 4 ₿for 5 days, but averagely decreased at 7. 6% by being stored at-80 ₿for more than 1 year. Compared with others, the deviation was-2. 9%-3. 6%. The differences in precision, accuracy and recovery of this method among the three different hospitals is slightly.The performance of direct CLIA for 25(OH)D assay meet the basic technical requirements for laboratory medicine, and is laborsaving and timesaving.

Objective Secretagogin, a Ca2+ binding protein, is one of the most abundant proteins in pancreatic β-cells and is critical for maintaining the structural integrity and signaling competence of β-cells. This study seeks to assess the concentrations of plasma secretagogin in participants with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (T2DM) and to explore its relationship to parameters of glucose and lipid metabolism, first-phase insulin secretion, insulin resistance and pancreatic β-cell function. Materials and Methods A total of 126 eligible subjects were divided into three groups: a normal glucose tolerance (NGT, n=45), a pre-DM (n=30), and a T2DM (n=51) group. An intravenous glucose tolerance test (IVGTT) was performed, and clinical and biochemical parameters were measured for all subjects. Results Plasma secretagogin levels were significantly higher in both pre-DM and T2DM patients compared with NGT subjects and were highest in the T2DM group. Correlation analysis showed that plasma secretagogin levels were positively correlated with fasting plasma glucose, postchallenge plasma glucose (2hPG), HbA1c and body mass index (BMI) but were not correlated with waist-hip ratio, blood pressure, lipid profiles, fasting serum insulin, homeostasis model assessment for insulin resistance, homeostasis model assessment for β-cell function and first-phase insulin secretion indicators. Multiple logistic regression analysis revealed that 2hPG and BMI were independent predictors for elevation of plasma secretagogin concentrations. Conclusions Increased circulating secretagogin might be a molecular predictor for early diagnosis of diabetes. Further studies are needed to confirm this finding and explore the role of secretagogin in obesity.

The YAP signaling activation in epithelial cells is essential for intestinal regeneration and tumorigenesis. However, the molecular mechanism linking stromal signals to YAP-mediated intestinal regeneration and tumorigenesis is poorly defined. Here we report a stroma-epithelia YAP signaling axis essential for stromal cells to modulate epithelial cell growth during intestinal regeneration and tumorigenesis. Specifically, upon inflammation and in cancer, an oncogenic transcription factor ETS1 in stromal cells induces expression of a secreted protein ISLR that can directly binds to a transmembrane protocadherin FAT1 on the surface of epithelial cells. This binding suppressed the Hippo signaling by disrupting MST1-FAT1 association, resulting in YAP signaling activation. Deletion of Islr in stromal cells in mice markedly impaired intestinal regeneration, and suppressed tumorigenesis in the colon. Moreover, the expression of stromal cell-specific ISLR and ETS1 significantly increased in inflamed mucosa of human IBD patients and in human colorectal adenocarcinoma, accounting for the epithelial YAP hyperactivation. Collectively, our findings uncovered a molecular mechanism governing signals for communication between stroma and epithelium during tissue regeneration and tumorigenesis.

A series of potential chiral compounds containing an α,β-unsaturated ketone was developed for anion detection. The interplay of compounds and biological momentous anions (Cl−, H2PO4−, I−, AcO−, HS−, F−, and Br−) was evaluated by UV-vis experiments, fluorescence experiments, and electrochemical tests. By comparison, compound 1 had the best selectivity and compound 5 had the strongest binding ability among the five compounds. And compound 5 had the highest sensitivity to H2PO4− among the measured anions, and it also can be applied to actual samples, the content of H2PO4− tested in the potassium dihydrogen phosphate fertilizer solution reached above 97.5% of the marked content, and the recovery rates were within the range of 98.5–99.1%, attesting that this method was reliable for the test of H2PO4− in fertilizer. Through HRMS titration, circular dichroism and optical rotation experiments, the probable interacted mechanism was proved that the interaction site was the C=C of the α,β-unsaturated ketone structure. In addition, the interacted mechanism was researched from the perspective of chirality. Furthermore, theoretical investigation analysis was introduced to reveal that the roles of molecular frontier orbitals in molecular interplay were determined. Therefore, this series of potential chiral compounds has potential application prospects in anion recognition.

We present a method of fitting optical spectra of galaxies using a basis set of six vectors obtained from principal component analysis (PCA) of a library of synthetic spectra of 40000 star formation histories (SFHs). Using this library, we provide estimates of resolved effective stellar mass-to-light ratio ($\log \Upsilon^*$) for thousands of galaxies from the SDSS-IV/MaNGA integral-field spectroscopic survey. Using a testing framework built on additional synthetic SFHs, we show that the estimates of stellar mass-to-light ratio are reliable (as are their uncertainties) at a variety of signal-to-noise ratios, stellar metallicities, and dust attenuation conditions. Finally, we describe the future release of the resolved stellar mass-to-light ratios as a SDSS-IV/MaNGA Value-Added Catalog (VAC) and provide a link to the software used to conduct this analysis.

We present a sample of 48 nearby galaxies with central, biconical outflows identified by the Mapping Nearby Galaxies at APO (MaNGA) survey. All considered galaxies have star formation driven bi-conical central outflows (SFB), with no signs of AGN. We find that the SFB outflows require high central concentration of the star formation rate. This increases the gas velocity dispersion over the equilibrium limit and helps maintain the gas outflows. The central starbursts increase the metallicity, extinction, and the alpha/Fe ratio in the gas. Significant amount of young stellar population at the centers suggests that the SFBs are associated with the formation of young bulges in galaxies. More than 70% of SFB galaxies are group members or have companions with no prominent interaction, or show asymmetry of external isophotes. In 15% SFB cases stars and gas rotate in the opposite directions, which points at the gas infall from satellites as the primary reason for triggering the SFB phenomena., 10 pages, 10 figures. Accepted by ApJ

Ethnopharmacological relevance Si-Miao-Yong-An decoction (SMYAD) is a traditional Chinese herbal formulation. SMYAD first appeared in the Eastern Han Dynasty according to the “Shen Yi Mi Zhuan”. Then the formula was recorded in the “Yan Fang Xin Bian” edited by medical scientist Bao Xiangao in the Qing Dynasty. This well-known prescription has been traditionally used for gangrene and vascular vasculitis. It is mainly used for cardiovascular and endocrine diseases in current clinical applications and research. Aim of study In this study, the potential mechanisms of SMYAD against cardiac fibrosis and hypertrophy in the β-adrenoceptor agonist isoprenaline induced heart failure model were investigated. Materials and methods The heart failure animal model was established via injected isoprenaline in rats. Echocardiography was used to detect the structure and function of the heart. HE staining and Masson's trichrome staining was performed to assess myocardial tissue morphology. The serum biochemical indexes were detected by dedicated biochemical kit. BNP was tested by ELISA kit. The levels of mRNA were detected by RT-qPCR. Cardiomyocyte morphology was assessed by immunofluorescence. Phosphorylated and total p38, Akt were analyzed by Western blot. The production of reactive oxygen species (ROS) was tested by CM-H2DCFDA probe. Formula identification of chemical constituents of SMYAD in plasma was disclosed through ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS). Results SMYAD was able to improve the heart function in ISO induced heart failure rat model via protecting rat from developing cardiac hypertrophy and fibrosis. SMYAD also decreased plasma expression of these biochemical indexes. It was found that SMYAD could regulate cardiac hypertrophy and fibrosis makers’ mRNA levels in vitro and vivo. In addition, SMYAD inhibited the phosphorylation of p38 and Akt, which are key mediators in the pathological process of ISO-induced cardiac hypertrophy and myocardial fibrosis. It also showed that the components of SMYAD in rat plasma exerted myocardial cell protective activity. Conclusion In summary, SMYAD may comprise more than one active ingredient to the pursuit of combination therapies instead of specifically target a single disease-causing molecule. These experimental results suggest that SMYAD may be a potential drug candidate in diseases of cardiac hypertrophy and myocardial fibrosis caused by β-adrenoceptor abnormalities.

We analyze the intrinsic velocity dispersion properties of 648 star-forming galaxies observed by the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, to explore the relation of intrinsic gas velocity dispersions with star formation rates (SFRs), SFR surface densities ($\rm{\Sigma_{SFR}}$), stellar masses and stellar mass surface densities ($\rm{\Sigma_{*}}$). By combining with high z galaxies, we found that there is a good correlation between the velocity dispersion and the SFR as well as $\rm{\Sigma_{SFR}}$. But the correlation between the velocity dispersion and the stellar mass as well as $\rm{\Sigma_{*}}$ is moderate. By comparing our results with predictions of theoretical models, we found that the energy feedback from star formation processes alone and the gravitational instability alone can not fully explain simultaneously the observed velocity-dispersion/SFR and velocity-dispersion/$\rm{\Sigma_{SFR}}$ relationships., Comment: 11 pages, 11 figures. Accepted for publication in MNRAS

Using the integral field unit (IFU) data from Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, we study the kinematics of gas and stellar components in an edge-on Seyfert 2 galaxy, SDSS J171359.00+333625.5, with X-shaped bi-conical outflows. The gas and stars therein are found to be counter-rotating, indicating that the collision between the inner and external gas might be an effective way to dissipate the angular momentum, which leads to remarkable gas accretion into the galaxy center. Large [OIII]$\lambda$5007 equivalent width and AGN-like line ratio in the large bi-conical region suggest that the gas is ionized by the central AGN. The gas velocity in the bi-cone region shows that ionized gas is receding relative to the galaxy center, which could be the joint effect of inflows, outflows and disk rotation. We are probably witnessing the case where a great amount of gas in the disk is being efficiently accreted into the central black hole, and the AGN-driven galactic winds are blown out along the bi-cone. The kinematics of oxygen, including rotation velocity and velocity dispersion, is different from other elements, like hydrogen, nitrogen and sulfur. The rotation velocity estimated from oxygen is slower than from other elements. The velocity dispersion of other elements follows galactic gravitational potential, while the velocity dispersion of oxygen stays roughly constant along the galactic major-axis. The further advanced observations, e.g. of cold gas or with an IFU of higher spatial resolution, are required to better understand this object., Comment: 11 pages, 7 figures, accepted by MNRAS

Negative feedback from accretion onto super-massive black holes (SMBHs), that is to remove gas and suppress star formation in galaxies, has been widely suggested. However, for Seyfert galaxies which harbor less active, moderately accreting SMBHs in the local universe, the feedback capability of their black hole activity is elusive. We present spatially-resolved H$\alpha$ measurements to trace ongoing star formation in Seyfert galaxies and compare their specific star formation rate with a sample of star-forming galaxies whose global galaxy properties are controlled to be the same as the Seyferts. From the comparison we find that the star formation rates within central kpc of Seyfert galaxies are mildly suppressed as compared to the matched normal star forming galaxies. This suggests that the feedback of moderate SMBH accretion could, to some extent, regulate the ongoing star formation in these intermediate to late type galaxies under secular evolution., Comment: 12 pages, 7 figures, accepted by MNRAS

ObjectiveSystematic Review was used to evaluate the efficacy and safety of Dalfampridine (DAP) in the treatment of Mobility Disability (MS) in patients with Multiple Sclerosis.MethodsClinical randomized controlled studies about DAP and placebo in the treatment of Mobility Disability in patients with Multiple Sclerosis until March 2019 were explored by searching Embase, PubMed, Cochrane, Web of Knowledge, and ClinicalTrials.gov. Literature screening, data extraction, quality assessment, and statistical analysis were performed by using Stata 14.0.Results10 papers were included in the meta-analysis, and the number of patients was 2100. In conclusion, the application of DAP in clinical can significantly improve the Mobility Disability of patients [OR = 2.73, 95%CI (1.66, 4.50), P10 mg) is a litter higher than the placebo control group.ConclusionDAP can effectively improve Mobility Disability in patients with Multiple Sclerosis, which is safe and reliable in specific DAP usage doses.

Galaxy mergers and interactions are expected to play a significant role leading to offsets between gas and stellar motions in galaxies. Herein we crossmatch galaxies in MaNGA MPL-8 with the Dark Energy Spectroscopic Instrument (DESI) Legacy Surveys and identify 311 merging galaxies that have reliable measurements of the $\Delta$PA, the difference between the stellar and gas kinematic position angles to investigate the impacts of merging on gas-stellar rotation misalignments. We find that the merging fractions of misaligned galaxies (30$^\circ$ $\leqslant$ $\Delta$PA $, Comment: 11 pages, 6 figures, accepted by MNRAS

MiRNAs regulate the cardiomyocyte (CM) cell cycle at the post-transcriptional level, affect cell proliferation, and intervene in harmed CM repair post-injury. The present study was undertaken to characterize the role of let-7i-5p in the processes of CM cell cycle and proliferation and to reveal the mechanisms thereof. In the present study, we used real-time qPCR (RT-qPCR) to determine the up-regulated let-7i-5p in CMs during the postnatal switch from proliferation to terminal differentiation and further validated the role of let-7i-5p by loss- and gain-of-function of let-7i-5p in CMs in vitro and in vivo. We found that the overexpression of let-7i-5p inhibited CM proliferation, whereas the suppression of let-7i-5p significantly facilitated CM proliferation. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of CMs. Supperession of let-7i-5p promoted the recovery of heart function post-myocardial infarction by enhancing E2F2 and CCND2. Collectively, our results revealed that let-7i-5p is involved in the regulation of the CM cell cycle and further impacts proliferation, which may offer a new potential therapeutic strategy for cardiac repair after ischemic injury.

Background Antisense long noncoding RNAs (lnc RNA s) are single‐stranded RNA s that overlapped gene‐coding regions on the opposite DNA strand and play as critical regulators in cardiovascular diseases. The high conservation and stability may be good advantages for antisense lnc RNA s. However, the roles of antisense lnc RNA s in cardiomyocyte proliferation and cardiac regeneration are still unknown. Methods and Results In this study, we found that Silent information regulator factor 2 related enzyme 1 (Sirt1) antisense lnc RNA expression was significantly increased during heart development. By gain and loss function of Sirt1 antisense lnc RNA using adenovirus and locked nucleic acid, respectively, we demonstrated that Sirt1 antisense lnc RNA promoted cardiomyocyte proliferation in vitro and in vivo, and the suppression of Sirt1 antisense lnc RNA inhibited cardiomyocyte proliferation. Moreover, overexpression of Sirt1 antisense lnc RNA enhanced cardiomyocyte proliferation, attenuated cardiomyocyte apoptosis, improved cardiac function, and decreased mortality rate after myocardial infarction. Furthermore, Sirt1 antisense lnc RNA can bind the Sirt1 3′‐untranslated region, enhancing the stability of Sirt1 and increasing Sirt1 abundance at both the mRNA and protein levels. Finally, we found that Sirt1 was involved in Sirt1 antisense lnc RNA ‐induced cardiomyocyte proliferation. Conclusions The present study identified Sirt1 antisense lnc RNA as a novel regulator of cardiomyocyte proliferation and cardiac regeneration by interacting and stabilizing Sirt1 mRNA , which may serve as an effective gene target for preventing myocardial infarction.

A series of chemsensors (1–4) containing fluorobenzene group based on coumarin derivatives have been developed for the selective and sensitive detection of H2S. The advantages of the synthesized fluorescent probe (compound 1) were the low detection limit (4 × 10−6 mol·L−1), good selectivity and high sensitivity which had been demonstrated through UV-vis, fluorescent titration experiments. Besides cytotoxicity test of compounds (1 and 2) was studied and the results indicated that compounds (1 and 2) showed almost no cytotoxicityat at a concentration of 150 μg·mL−1. The interacted mechanism was the thiolysis reaction of dinitrophenyl ether which had been confirmed by fluorescence and HRMS titration experiment. In addition, probe 1 can also detect HS− selectively by naked eye in pure DMSO solvent.

Roxarsone (ROX), as an antibiotic widely used in livestock industry, faces enormous challenges in its safe and effective disposal. Schwertmannite (Sch) is regarded as an appropriate environmental material for ROX decontamination, owing to its bi-functional properties of Fenton-activation and arsenic-sorption. In this study, MoS2-modified Sch (MoS2@Sch) catalyst was constructed to improve the catalytic activity for photo-Fenton reaction. The resultant MoS2@Sch showed a uniform spheroidal particles structure with average size of 750 nm, and Fe-O-Mo bond was formed in MoS2@Sch structure. Above 85% of ROX was efficiently degraded by MoS2@Sch-mediated UV-assisted heterogeneous Fenton reaction within 40 min, and the generated arsenate (As(V)) was simultaneously immobilized by catalyst. The contribution of reactive species involved in UV/MoS2@Sch-H2O2 reaction followed an order of OH ≫ O2– > h+. The improved catalytic activity of MoS2@Sch was attributable to more effective Fe3+/Fe2+ conversion, which originated from the extra electron supply from Mo4+ redox and MoS2 excitation under UV irradiation. According to theoretical computation and intermediates identification, ROX was finally transformed into CO2, NO3–, and As(V). The finding indicated that Sch-based material was alternative catalyst to realize the safe disposal of organoarsenic, whereas the stability and reusability should be further optimized for practical application.

Background and objective Due to the lack of training data, the accurate classification of skin lesions still has great challenges. Generative adversarial networks (GANs) have been used to synthesize dermoscopy images successfully. Unfortunately, previous methods usually directly feed category labels into GANs and cannot provide effective information gain for the classification model. This paper studies a specific conditional image synthesis method, which could convert semantic segmentation map to dermoscopy image. Methods We proposed a conditional GANs (CGAN) for high-resolution dermoscopy images synthesis. First, we established an effective label mapping with pathological significance by combining the segmentation mask and category label of skin lesions. Then, a CGAN based on the image-to-image translation framework is constructed and took the previous label mapping as input to generate dermoscopy images. Especially, the shallow and deep features are combined together in the generator to avoid the loss of semantic information, and discriminator-based feature matching loss is introduced to improve the quality of generated images. Results The proposed method is evaluated in ISIC-2017 skin dataset. Compared with several representative GANs architectures including the newest semantic image synthesis method, the proposed method has better performance in both visual effect and quantitative evaluation. Moreover, by using the generated images, the average AUC values of several skin lesion classification models can be improved effectively. Conclusions The proposed method can generate high-realistic and high-resolution demoscopy images, leading to performance improvement of skin lesion classification models, which could also be helpful for solving data shortages and classes imbalance problems in the field of medical image analysis.

Histone acetylation is a prevalent post-translational modification phenomenon, which is closely related to numerous physiological and pathological processes. In this work, a label-free ratiometric fluorescent biosensing platform based on the change of fluorescence resonance energy transfer (FRET) ratio from polyfluorene derivative (PFP) to fluorescein (FL) via competitive reactions is designed for monitoring histone acetylation. Polycationic substrate peptides could gradually displace PFP in PFP/FL probe, thus resulting in low FRET efficiency. In the presence of histone acetyltransferases (HAT), it can catalyze the acetylation of substrate polypeptide lysine residue, altering the intrinsic charge and diminishing the electrostatic interaction with fluorescein, leading to FRET recovery. Under the optimal conditions, the fabricated assay exhibits a wide linear range of 0.5–500 nM with a detection limit of 0.21 nM for HAT activity detection. The assay was applied to evaluate HAT inhibition by C646, and an IC50 value of 24.3 µM was obtained. Moreover, the proposed method is applicable for the evaluation of histone deacetylases (HDAC) activity with a linear range from 0.5 to 500 nM and a detection limit of 0.46 nM. The developed protocol could be a promising prospect for clinical diagnosis and drug discovery that are related to HAT/HDAC activity.

Three new heterometallic coordination polymers [Dy2(pydc)6Mg3(H2O)6]·11H2O (1), [Dy(pydc)3][Mg(H2O)6]·Him·7H2O (2), and [Dy(pydc)3(im)2Mg(H2O)2]·Him·3H2O (3) (H2pydc = pyridine-2,6-dicarbolylic acid, im = imidazole) were solvothermally synthesized by reacting H2pydc, Dy(NO3)3·6H2O, MgCl2·6H2O and imidazole at 393 K for 48 h. They were characterized by elemental analysis, IR, TG and XRD. The three compounds are different in structure. Coordination polymer 1 exhibits a three-dimensional network structure with topology symbol of {44.62}3{49.66}2. Complex 2 is a zero-dimensional ionic complex. Coordination polymer 3 displays a one-dimensional chain structure. The solid-state luminescence properties for 1–3 were determined. They all show characteristic emission spectra of Dy(III) ions.

Coordination polymers [Ln(bta)0.5(ox)0.5(H2O)2]·2H2O (Ln = Tb (1), Eu (2), H2ox = oxalic acid; H4bta = 1,2,4,5-benzenetetracarboxylic acid) were hydrothermally synthesized, and characterized by elemental analysis, IR, TG, XRD as well as single-crystal X-ray diffraction. Coordination polymers 1–2 display three-dimensional (3D) network structures, which can be simplified into a 3D network with topology symbol of {412·63}, and the topology type is pcu. The luminescence properties of 1 and 2 show characteristic emission of Tb(III) and Eu(III) ions, respectively. The solid-state quantum yield Фtotal is 19.96 ± 2.00% and 6.84 ± 0.68% while the fluorescence decay lifetime is τ = 560.2990 μs and τ = 233.8299 μs for 1 and 2, respectively.

Red-emitting CaMoO4:Eu3+ nanosheets were prepared via a facile precipitation method at room temperature without any organic additives. The structural characterization indicates that these nanosheets are single-crystalline with an average diameter of ∼1.657 μm and a thickness of ∼10 nm. We investigated the high-pressure behaviors of bulk CaMoO4 and CaMoO4:Eu3+ nanosheets by in situ high-pressure synchrotron angle-dispersive X-ray diffraction (XRD) technique at room temperature with the pressures up to 35.0 and 40.1 GPa, respectively. Two pressure-induced phase transitions were observed for both bulk CaMoO4 and CaMoO4:Eu3+ nanosheets in the range of studied pressure. The two high-pressure phases were analyzed and identified to be monoclinic structures with I2/a and P21/n space group, respectively. The compressibility of the CaMoO4 is highly non-isotropic, and the c-axis is more compressible than a-axis and b-axis. Furthermore, the compressibility of the c-axis of CaMoO4:Eu3+ nanosheets is greater than that of bulk CaMoO4. On the release of pressure from 35.0 to 40.1 GPa, the initial phase is recovered, implying that the observed structural modifications are reversible. CaMoO4: Eu3+ sheets also show higher luminescence efficiency that of bulk CaMoO4: Eu3+, which is reflected in higher Ω2 value. The continuous shift of emission peaks indicates the changes in local symmetry of Eu3+ with pressure, which is consistent with our high-pressure XRD study. The potential applications of CaMoO4:Eu3+ nanosheets were explored and our findings show that white light with excellent color quality (CRI>90) and a high LER up to 345 lm/W could be achieved.

Two new heterometallic coordination polymers (CPs) [Ln2 (pydc)6Mg3(H2O)6]·11H2O (Ln ​= ​Eu (1), Tb (2); H2pydc ​= ​pyridine-2,6-dicarbolylic acid) were synthesized by solvothermal method at 120 ​°C in 48 ​h. Interestingly, after being left in the mother liquor for 3 days at room temperature, the crystal structures of the coordination polymers transform into anionic complexes 2 [Mg(H2O)6]·2 [Ln (pydc)3]·2Him·im•8H2O (Ln ​= ​Eu (3), Tb (4); im ​= ​imidazole; Him ​= ​protonated imidazole) by single-crystal-to-single-crystal transformation. The four complexes were characterized by elemental analysis, IR, TG, XRD as well as single-crystal X-ray diffraction. Coordination polymers 1 and 2 exhibit three-dimensional network structure and their topology symbol is {44.62}3{49.66}2, whereas complexes 3 and 4 are zero dimensional molecules. The luminescence properties of the complexes were determined at solid state. They show characteristic emission spectra of Eu(III) and Tb(III) ions, respectively. The quantum yield Фtotal is 48.42 ​± ​10%, 95.65 ​± ​10%, 44.22 ​± ​10%, and 76.97 ​± ​10% for coordination polymers 1 (Mg–Eu), 2 (Mg–Tb), 3 (Mg–Eu), and 4 (Mg–Tb), respectively. The corresponding fluorescence decay lifetime of 1–4 is τobs1 ​= ​1884.72 ​± ​1.51, 1777.75 ​± ​1.45, 1625.17 ​± ​1.40, and 1487.75 ​± ​1.36 ​μs? The effect of Mg(II) on the fluorescence properties of the lanthanide coordination polymers was investigated.