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204. High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation

Author

Anli Wang, Xuzhi Wan, Pan Zhuang, Wei Jia, Yang Ao, Xiaohui Liu, Yimei Tian, Li Zhu, Yingyu Huang, Jianxin Yao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Jiye Wang, Weixuan Yao, Jingjing Jiao, and Yu Zhang

Subjects
Multidisciplinary
Abstract

Western dietary patterns have been unfavorably linked with mental health. However, the long-term effects of habitual fried food consumption on anxiety and depression and underlying mechanisms remain unclear. Our population-based study with 140,728 people revealed that frequent fried food consumption, especially fried potato consumption, is strongly associated with 12% and 7% higher risk of anxiety and depression, respectively. The associations were more pronounced among male and younger consumers. Consistently, long-term exposure to acrylamide, a representative food processing contaminant in fried products, exacerbates scototaxis and thigmotaxis, and further impairs exploration ability and sociality of adult zebrafish, showing anxiety- and depressive-like behaviors. Moreover, treatment with acrylamide significantly down-regulates the gene expression of tjp2a related to the permeability of blood–brain barrier. Multiomics analysis showed that chronic exposure to acrylamide induces cerebral lipid metabolism disturbance and neuroinflammation. PPAR signaling pathway mediates acrylamide-induced lipid metabolism disorder in the brain of zebrafish. Especially, chronic exposure to acrylamide dysregulates sphingolipid and phospholipid metabolism, which plays important roles in the development of anxiety and depression symptoms. In addition, acrylamide promotes lipid peroxidation and oxidation stress, which participate in cerebral neuroinflammation. Acrylamide dramatically increases the markers of lipid peroxidation, including (±)5-HETE, 11(S)-HETE, 5-oxoETE, and up-regulates the expression of proinflammatory lipid mediators such as (±)12-HETE and 14(S)-HDHA, indicating elevated cerebral inflammatory status after chronic exposure to acrylamide. Together, these results both epidemiologically and mechanistically provide strong evidence to unravel the mechanism of acrylamide-triggered anxiety and depression, and highlight the significance of reducing fried food consumption for mental health.

Published
2023
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205. Supplementary Tables S1-3 from Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma

Author

Hui-Chuan Sun, De-Ning Ma, Bo-Gen Ye, Ning Zhang, Ling-Qun Kong, Ke-Zhi Zhang, Yuan-Yuan Zhang, Hao Cai, Zong-Tao Chai, Xiao-Dong Zhu, and Jian-Yang Ao

Abstract

Supplementary Table S1: Primer sequence of gene used for qPCR in mouse. Supplementary Table S2: Primer sequence of gene used for qPCR in human. Supplementary Table S3: List of antibodies used for immunohistochemical staining.

Published
2023
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207. Supplementary figures S1-9 from Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma

Author

Hui-Chuan Sun, De-Ning Ma, Bo-Gen Ye, Ning Zhang, Ling-Qun Kong, Ke-Zhi Zhang, Yuan-Yuan Zhang, Hao Cai, Zong-Tao Chai, Xiao-Dong Zhu, and Jian-Yang Ao

Abstract

Figure S1. Microscope pictures, and CSF1R expression of M(CSF1) cells and M(CSF2) cells. Figure S2. Microarray and qRT-PCR difference between M(LPS IFNÃŽÃ,³)/M(IL4), and between M(CSF1)/M(CSF2) cells. Figure S3. Effect of PLX3397 on the population doubling curve of the hepatoma cell lines, HUVEC, LX2, M(CSF2) cells, and T cells. Figure S4. Microvessel density expression in the vehicle and PLX3397 groups. Figure S5. TAMs of PLX3397-treated tumors were promoted towards a M1 phenotype. Figure S6. CSF2 is a key factor in between M(CSF1) and M(CSF2) cells. Figure S7. The tumor immunity environment was ameliorated after CSF1R inhibition in the allograft hepatoma model. Figure S8. CSF1R inhibition retarded HepG2 and HCCLM3 mice orthotopic xenograft growth. Figure S9. TAMs of PLX3397-treated tumors were promoted towards a M1 phenotype was also found in the xenografts after CSF1R inhibition.

Published
2023
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226. Colony-stimulating factor-1-induced AIF1 expression in tumor-associated macrophages enhances the progression of hepatocellular carcinoma

Author

Hao Cai, Xiao-Dong Zhu, Jian-Yang Ao, Bo-Gen Ye, Yuan-Yuan Zhang, Zong-Tao Chai, Cheng-Hao Wang, Wen-Kai Shi, Man-Qing Cao, Xiao-Long Li, and Hui-Chuan Sun

Subjects
aif1, c-jun, csf1/csf1r, cxcl16, hepatocellular carcinoma, tumor-associated macrophages, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

M2-polarized (alternatively activated) macrophages play an important role in the progression of hepatocellular carcinoma (HCC). Allograft inflammatory factor 1 (AIF1) is overexpressed in M2-polarized macrophages. This study explored the role of AIF1 in tumor-associated macrophages in HCC. Macrophages were stimulated with colony-stimulating factor 1 (CSF1) to characterize the regulatory pathway of AIF1 in macrophages. The chromatin immunoprecipitation and luciferase reporter gene assay were conducted to examine transcription factors associated with AIF1 expression. AIF1 was down or upregulated, and the effects on tumor progression were evaluated by using in vitro and in vivo co-culture systems. A cytokine array was performed to screen the downstream functional components of AIF1. Tumor tissue from 206 patients with HCC were used to explore the clinical significance of AIF1. AIF1 induced a M2-like phenotype of macrophages. By facilitating the binding of c-Jun to the promoter of AIF1, CSF1 secreted from hepatoma cells increased AIF1 expression through the CSF1R-MEK1/2-Erk1/2-c-Jun axis. AIF1 expressed in macrophages promoted the migration of hepatoma cells in co-culture system of RAW264.7 and Hepa1-6 and tumor growth in an animal model. The cytokine array showed that CXCL16 was increased in RAW264.7 cells with overexpressed AIF1, leading to enhanced tumor cell migration. In human HCC tissue, AIF1-positive macrophages in the adjacent microenvironment was associated with microvascular invasion and advanced TNM stages and with patients' overall and disease-free survival (p = 0.002 for both). AIF1 expression in macrophages plays a pivotal role in the interaction between macrophages and hepatoma cells.

Published
2017
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228. Microsatellite records for volume 8, issue 4

Author

Ojeda, Alejandra Paola, Hilsdorf, Alexandre Wagner Silva, Leite, Ana Caroline, Yang, Ao-ao, Izuno, Ayako, He, Chongbo, Zhou, Chun-ya, Kyogoku, Daisuke, Caneppele, Danilo, Zhu, Dongmei, da Fonseca, Fernando Stopato, Yin, Hao, Kato, Hidetoshi, Vilar, Jackeline Alves, Li, Jiale, Peng, Jianqing, Arima, Kurumi, Zhu, Ling, Yefeng, L. V., Tian, Meilin, Di, Mingyu, Nakahama, Naoyuki, Li, Shilei, Wang, Weimin, Song, Wen, Liu, Weidong, Liu, Xiaojun, Han, Xuekai, Pan, Ying, Su, Yong-quan, Tsuda, Yuichi, Isagi, Yuji, Li, Yunfeng, Zhuang, Zhi-meng, Bai, Zhiyi, and Zhou, Zunchun

Published
2016
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229. Analysis and Design of the LC Filter Rectifier With Zero Input Impedance Angle for IPT System

Author

Mai, Jianwei, Yang, Ao, Wang, Yijie, and Xu, Dianguo

Abstract

An LC filter rectifier with a diode bridge is widely used in an inductive power transfer (IPT) system. However, when the load resistance reduces, the rectifier input impedance becomes capacitive. In addition, the filtered inductor is not infinite, and its harmonic currents cause the input impedance to be biased inductively. In order to solve the above two problems, a novel LC filter rectifier is proposed in this article, which achieves zero input impedance angle of the rectifier. First, the mechanism of the traditional LC rectifier filter is analyzed in detail, and an accurate circuit model is proposed. Then, an improved LC filter rectifier is analyzed and designed, and the input impedance angle of the rectifier is zero. Finally, a prototype with the load of 8–120 Ω is built, which verified the correctness and feasibility of the improved rectifier. Compared with the traditional rectifier, the efficiency of the IPT system with an improved rectifier is increased by 1.10%, and the output voltage fluctuation is smaller.

Published
2023
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240. The divergent vertical pattern and assembly of soil bacterial and fungal communities in response to short-term warming in an alpine peatland

Author

Wang, Xiaodong, primary, Li, Yong, additional, Yan, Zhongqing, additional, Hao, Yanbin, additional, Kang, Enze, additional, Zhang, Xiaodong, additional, Li, Meng, additional, Zhang, Kerou, additional, Yan, Liang, additional, Yang, Ao, additional, Niu, Yuechuan, additional, and Kang, Xiaoming, additional

Published
2022
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