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1,207 results on '"Yamada, Ryo"'

215. Serum microRNA-126 and -223 as new-generation biomarkers for sarcoidosis in patients with heart failure

Author

Fujiwara, Wakaya, primary, Kato, Yasuchika, additional, Hayashi, Mutsuharu, additional, Sugishita, Yoshinori, additional, Okumura, Satoshi, additional, Yoshinaga, Masataka, additional, Ishiguro, Tomoya, additional, Yamada, Ryo, additional, Ueda, Sayano, additional, Harada, Masahide, additional, Naruse, Hiroyuki, additional, Ishii, Junnichi, additional, Ozaki, Yukio, additional, and Izawa, Hideo, additional

Published
2018
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224. Additional file 5: Figure S4. of A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension

Author

Higasa, Koichiro, Ogawa, Aiko, Terao, Chikashi, Shimizu, Masakazu, Kosugi, Shinji, Yamada, Ryo, Date, Hiroshi, Matsubara, Hiromi, and Matsuda, Fumihiko

Abstract

Disruption of wild type acceptor site by the single nucleotide variants (c.853-2Aâ >â G) predicted from in silico programs. (PDF 184Â kb)

Published
2017
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225. Additional file 4: Figure S3. of A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension

Author

Higasa, Koichiro, Ogawa, Aiko, Terao, Chikashi, Shimizu, Masakazu, Kosugi, Shinji, Yamada, Ryo, Date, Hiroshi, Matsubara, Hiromi, and Matsuda, Fumihiko

Abstract

Creation of the new splice acceptor site by the three base insertion (NM_001204.6:c.1277-10_1277-9insGGG) predicted from in silico programs. (PDF 218Â kb)

Published
2017
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226. Additional file 3: Figure S2. of A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension

Author

Higasa, Koichiro, Ogawa, Aiko, Terao, Chikashi, Shimizu, Masakazu, Kosugi, Shinji, Yamada, Ryo, Date, Hiroshi, Matsubara, Hiromi, and Matsuda, Fumihiko

Abstract

Possible pathogenic variants found in the intron of BMPR2 in family 4. A rare three base insertion (GGG) at 10 bases upstream from exon 10 creates identical sequences around the canonical splicing site (ACAGGG). By the insertion, an out-of-frame protein could be translated due to the new splice acceptor site. (PDF 411Â kb)

Published
2017
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228. Additional file 2: Figure S1. of A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension

Author

Higasa, Koichiro, Ogawa, Aiko, Terao, Chikashi, Shimizu, Masakazu, Kosugi, Shinji, Yamada, Ryo, Date, Hiroshi, Matsubara, Hiromi, and Matsuda, Fumihiko

Abstract

Large deletion found in the patient in family 8. (a) The large deletion was supported by depth of coverage and discordant paired-end reads. (b) The length of the deletion was approximately 6.5 kilobases and spanned the entire region of exon 3. Breakpoints of the large heterozygous deletion were located in the Alu repeat sequences, which were supported by read depths and paired-end reads spanning the long region. (PDF 529Â kb)

Published
2017
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233. A Circularly Arranged Sextuple Triptycene Gear Molecule

Author

Ube, Hitoshi, Yamada, Ryo, Ishida, Jun-ichi, Sato, Hiroyasu, Shiro, Motoo, and Shionoya, Mitsuhiko

Abstract

Herein we report the synthesis of a circularly arranged sextuple triptycene gear molecule, hexakis(10-dodecyloxy-9-triptycyl)ethynylbenzene, via the trimerization of the corresponding triyne with a cobalt catalyst. The six triptycene gears are closely engaged with each other as confirmed by single crystal X-ray structure analysis, and their motion in solution was established by NMR spectroscopy. Notably, when one bulky RuCp* complex was attached to one triptycene gear, the whole movement of the six gears was highly restricted via their mechanical engagement. Development of such a multigear molecule would provide a structural basis for molecular motion transmission systems with a switching function.

Published
2024
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234. Multifunctional Octamethyltetrasila[2.2]cyclophanes: Conformational Variations, Circularly Polarized Luminescence, and Organic Electroluminescence

Author

Shimada, Masaki, Yamanoi, Yoshinori, Ohto, Tatsuhiko, Pham, Song-Toan, Yamada, Ryo, Tada, Hirokazu, Omoto, Kenichiro, Tashiro, Shohei, Shionoya, Mitsuhiko, Hattori, Mineyuki, Jimura, Keiko, Hayashi, Shigenobu, Koike, Hikaru, Iwamura, Munetaka, Nozaki, Koichi, and Nishihara, Hiroshi

Abstract

Both symmetrical and unsymmetrical cyclophanes containing disilane units, tetrasila[2.2]cyclophanes 1–9, were synthesized. The synand anticonformations and the kinetics of inversion between two anti-isomers were investigated by X-ray diffraction and variable-temperature NMR analysis, respectively. The flipping motion of two aromatic rings was affected by the bulkiness of the aromatic moiety (1vs 6), the phase (solid vs solution), and the inclusion by host molecules (1vs 1⊂[Ag2L]2+). The photophysical, electrochemical, and structural properties of the compounds were thoroughly investigated. Unsymmetrical tetrasila[2.2]cyclophanes 5–8displayed blue–green emission arising from intramolecular charge transfer. Compound 6emitted a brilliant green light in the solid state under 365 nm irradiation and showed a higher fluorescence quantum yield in the solid state (Φ = 0.49) than in solution (Φ = 0.05). We also obtained planar chiral tetrasila[2.2]cyclophane 9, which showed interesting chiroptical properties, such as a circularly polarized luminescence (CPL) with a dissymmetry factor of |glum| = ca. 2 × 10–3at 500 nm. Moreover, an organic green light-emitting diode that showed a maximum external quantum efficiency (ηext) of ca. 0.4% was fabricated by doping 4,4′-bis(2,2′-diphenylvinyl)-1,1′-biphenyl with 6.

Published
2024
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235. Electrical conductance measurement of HgII-mediated DNA duplex in buffered aqueous solution.

Author

Yamada, Ryo, Nomura, Issei, Yamaguchi, Yuki, Matsuda, Yosuke, Hattori, Yoshikazu, Tada, Hirokazu, Ono, Akira, and Tanaka, Yoshiyuki

Subjects
*AQUEOUS solutions, *SINGLE-stranded DNA, *DNA, *SCANNING tunneling microscopy
Abstract

Electrical properties of metal-mediated DNA duplexes (metallo-DNA) have been of particular interest because of their potential applications in DNA-based nanoelectronics. We prepared HgII-mediated DNA duplex with NH2 anchors and measured the electrical conductance of single-molecule metallo-DNA via scanning tunneling microscopy-based break junction method in the buffered solution. Three conductance values were observed that may correspond to different conformations of the metallo-DNA molecule bridged over metallic electrodes. [ABSTRACT FROM AUTHOR]

Published
2020
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236. Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson.

Author

Hosoda, Yoshikatsu, Miyake, Masahiro, Meguro, Akira, Tabara, Yasuharu, Iwai, Sachiko, Ueda-Arakawa, Naoko, Nakano, Eri, Mori, Yuki, Yoshikawa, Munemitsu, Nakanishi, Hideo, Khor, Chiea-Chuen, Saw, Seang-Mei, Yamada, Ryo, Matsuda, Fumihiko, Cheng, Ching-Yu, Mizuki, Nobuhisa, Tsujikawa, Akitaka, Yamashiro, Kenji, Kawaguchi, Takahisa, and Setoh, Kazuya

Subjects
KERATOCONUS, ARTIFICIAL intelligence, GENOMES, COMPUTER systems, CORNEAL transplantation
Abstract

Keratoconus is a common ocular disorder that causes progressive corneal thinning and is the leading indication for corneal transplantation. Central corneal thickness (CCT) is a highly heritable characteristic that is associated with keratoconus. In this two-stage genome-wide association study (GWAS) of CCT, we identified a locus for CCT, namely STON2 rs2371597 (P = 2.32 × 10−13), and confirmed a significant association between STON2 rs2371597 and keratoconus development (P = 0.041). Additionally, strong STON2 expression was observed in mouse corneal epithelial basal cells. We also identified SMAD3 rs12913547 as a susceptibility locus for keratoconus development using predictive analysis with IBM's Watson question answering computer system (P = 0.001). Further GWAS analyses combined with Watson could effectively reveal detailed pathways underlying keratoconus development. Yoshikatsu Hosoda et al. study the genetic basis for central corneal thickness (CCT) that is associated with keratoconus. They identify two susceptibility loci, STON2 rs2371597 and SMAD3 rs12913547, using two-step genome-wide association study (GWAS) and predictive analysis with IBM's Watson question answering computer system, respectively. [ABSTRACT FROM AUTHOR]

Published
2020
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240. Role of selected polymorphisms in determining muscle fiber composition in Japanese men and women

Author

Kumagai, Hiroshi, primary, Tobina, Takuro, additional, Ichinoseki-Sekine, Noriko, additional, Kakigi, Ryo, additional, Tsuzuki, Takamasa, additional, Zempo, Hirofumi, additional, Shiose, Keisuke, additional, Yoshimura, Eiichi, additional, Kumahara, Hideaki, additional, Ayabe, Makoto, additional, Higaki, Yasuki, additional, Yamada, Ryo, additional, Kobayashi, Hiroyuki, additional, Kiyonaga, Akira, additional, Naito, Hisashi, additional, Tanaka, Hiroaki, additional, and Fuku, Noriyuki, additional

Published
2018
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243. Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers

Author

Kawaguchi, Takahisa, primary, Shima, Toshihide, additional, Mizuno, Masayuki, additional, Mitsumoto, Yasuhide, additional, Umemura, Atsushi, additional, Kanbara, Yoshihiro, additional, Tanaka, Saiyu, additional, Sumida, Yoshio, additional, Yasui, Kohichiro, additional, Takahashi, Meiko, additional, Matsuo, Keitaro, additional, Itoh, Yoshito, additional, Tokushige, Katsutoshi, additional, Hashimoto, Etsuko, additional, Kiyosawa, Kendo, additional, Kawaguchi, Masanori, additional, Itoh, Hiroyuki, additional, Uto, Hirofumi, additional, Komorizono, Yasuji, additional, Shirabe, Ken, additional, Takami, Shiro, additional, Takamura, Toshinari, additional, Kawanaka, Miwa, additional, Yamada, Ryo, additional, Matsuda, Fumihiko, additional, and Okanoue, Takeshi, additional

Published
2018
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245. Relationship between slip angle in ramp test and coefficient of friction values at shoe-floor interface measured with cart-type friction measurement device

Author

YAMAGUCHI, Takeshi, primary, YAMADA, Ryo, additional, WARITA, Iori, additional, SHIBATA, Kei, additional, OHNISHI, Akihito, additional, SUGAMA, Atsushi, additional, HINOSHITA, Mamoru, additional, SAKAUCHI, Koichi, additional, MATSUKAWA, Seiko, additional, and HOKKIRIGAWA, Kazuo, additional

Published
2018
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