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To realize multi-band mode conversion in a high-power microwave incoherent power combination system, a tri-band conversion system (at X-, Ku-, and Ka-bands) is proposed in this paper. The tri-band conversion system mainly consists of three parts: a dual-band multiplexer, a circular waveguide with a 90° bend, and a tri-band mode converter. To investigate the mode coupling characteristics in the system, every part is carefully analyzed and verified. Numerical and simulation results show that the final conversion efficiencies of the conversion system are 98.9% [coaxial transverse electromagnetic (TEM) mode–coaxial TE11 mode at 10.16 GHz], 99.1% (coaxial TEM mode–coaxial TE11 mode at 14.45 GHz), and 99.6% (circular TM01–circular TE11 at 30.5 GHz). Meanwhile, its maximum power handling capacities reached 1.5 GW, 957.6 MW, and 726.2 MW. The good agreement between theoretical analyses and simulation results demonstrates that the proposed tri-band system is feasible in high-power microwave applications.

The auto-regulation method is a rising training strategy to improve strength and motor performance, and the Autoregulatory Progressive Resistance Exercise (APRE), Rating of Perceived Exertion program (RPE), and Velocity-Based Training (VBT) are the three common auto-regulation programs. However, whether the auto-regulation method is more effective than the traditional strength training (the fixed-loading method) in maximum strength training is still unclear. The present study searched the Pubmed, SPORTDiscus, Web of Science, Embase, EBSCO, Cochrane, CNKI, and CQVIP databases, and included eight related studies published between 2010 and 2020, with a total of 166 subjects including division 1 college players and athletes with at least 1-year training history, and interventions ranging from 5 to 10 weeks. A meta-analysis was performed to check the difference between the two training methods, and analyzed the differences in the existing auto-regulation programs' effectiveness. The overall results showed that the auto-regulation method was more effective than the fixed-loading method in maximum strength training (effect size = 0.64; P < 0.001; I2 = 0%). In specific, the pooled results in subgroup analysis indicated that the auto-regulation method may effectively improve the strength performance in squat (effect size = 4.64; P < 0.05; I2 = 54%) and bench press (effect size = 3.21; P < 0.05; I2 = 62%). Greater benefits of the auto-regulation method on strength improvement could be achieved in an 8-week or even shorter training (effect size = 0.87; P < 0.001; I2 = 0%) compared with those of 8–10 weeks (effect size = 0.32; P < 0.001; I2 = 0%). The APRE is the most effective training program among the three auto-regulation programs (effect size = 0.78; P < 0.001; I2 = 0%). In conclusion, the auto-regulation method could be more effective than the fixed-loading method in maximum strength training. The APRE is a convenient and effective training program that may be considered a practical training program to replace traditional training in athletes.

Obesogenic diets contribute to the pathology of osteoarthritis (OA) by altering systemic and local metabolic inflammation. Yet, it remains unclear how quickly and reproducibly the body responds to weight loss strategies and improve OA. In this study we tested whether switching obese diet to a normal chow diet can mitigate the detrimental effects of inflammatory pathways that contribute to OA pathology. Male C57BL/6 mice were first fed with obesogenic diet (high fat diet) and switched to normal chow diet (obese diet → normal diet) or continued obese diet or normal diet throughout the experiment. A mouse model of OA was induced by surgical destabilization of the medial meniscus (DMM) model into the knee joint. Outcome measures included changes in metabolic factors such as glucose, insulin, lipid, and serum cytokines levels. Inflammation in synovial biopsies was scored and inflammation was determined using FACs sorted macrophages. Cartilage degeneration was monitored using histopathology. Our results indicate, dietary switching (obese diet → normal diet) reduced body weight and restored metabolic parameters and showed less synovial tissue inflammation. Systemic blood concentrations of pro-inflammatory cytokines IL-1α, IL-6, IL-12p40, and IL-17 were decreased, and anti-inflammatory cytokines IL-4 and IL-13 were increased in dietary switch group compared to mice that were fed with obesogenic diet continuously. Although obese diet worsens the cartilage degeneration in DMM OA model, weight loss induced by dietary switch does not promote the histopathological changes of OA during this study period. Collectively, these data demonstrate that switching obesogenic diet to normal improved metabolic syndrome symptoms and can modulate both systemic and synovium inflammation levels.

PurposeBoth tinnitus and type 2 diabetes mellitus (T2DM) are linked with cognitive decline and brain dysfunction. This study used arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) to examine the abnormal cerebral blood flow (CBF) patterns existed in tinnitus patients and potential relationships between the abnormal CBF and cognitive performance. The impact of T2DM on CBF alterations in tinnitus patients was further explored.MethodsSixty tinnitus patients and 40 non-tinnitus subjects were recruited. CBF images were collected and analyzed using ASL perfusion fMRI. Brain regions with CBF alterations between tinnitus patients and non-tinnitus controls were identified by one-way analysis of variance. Interaction effects between tinnitus and T2DM for CBF changes were also selected. Then, correlation analyses were calculated to specify the link between CBF changes and cognitive performance and between CBF changes and diabetic characteristics.ResultsTinnitus patients showed decreased CBF, primarily in the auditory area and default mode network (DMN), compared with non-tinnitus controls. Decreased CBF in these regions was correlated with executive function and attention. The interaction effect between tinnitus and T2DM was significant in the right medial prefrontal gyrus. Additionally, CBF in the right medial prefrontal gyrus was correlated with tinnitus distress and cognitive performance. In tinnitus patients, Hemoglobin A1c was associated with CBF in the right medial prefrontal gyrus.ConclusionTinnitus affects brain perfusion in the auditory area and DMN. T2DM and uncontrolled glucose levels may aggravate a CBF decrease in tinnitus patients. These new findings implied that tinnitus patients may benefit from blood glucose control in terms of their cognitive function and tinnitus distress.

IntroductionKidney renal clear cell carcinoma (KIRC) has a high incidence globally, and its pathogenesis remains unclear. Long non-coding RNA (lncRNA), as a molecular sponge, participates in the regulation of competitive endogenous RNA (ceRNA). We aimed to construct a ceRNA network and screened out possible lncRNAs to predict KIRC prognosis.Material and methodsAll KIRC data were downloaded from the TCGA database and screened to find the possible target lncRNA; a ceRNA network was designed. Next, GO functional enrichment and KEGG pathway of differentially expressed mRNA related to lncRNA were performed. We used Kaplan-Meier curve analysis to predict the survival of these RNAs. We used Cox regression analysis to construct a model to predict KIRC prognosis.ResultsIn the KIRC datasets, 1457 lncRNA, 54 miRNA and 2307 mRNA were screened out. The constructed ceRNA network contained 81 lncRNAs, nine miRNAs, and 17 mRNAs differentially expressed in KIRC. Survival analysis of all differentially expressed RNAs showed that 21 lncRNAs, four miRNAs, and two mRNAs were related to the overall survival rate. Cox regression analysis was performed again, and we found that eight lncRNAs were related to prognosis and used to construct predictive models. Three lnRNAs from independent samples were meaningful.ConclusionThe construction of ceRNA network was involved in the process and transfer of KIRC, and three lncRNAs may be potential targets for predicting KIRC prognosis.

To study the effect of loading rate on the progressive damage and failure characteristics of coal, an ultrasonic detector and a camera were used to measure the P-wave velocity and record the failure process of cuboid coal samples in uniaxial compression tests with five loading rates. The mechanical properties, damage process, and failure characteristics of the samples were analysed, and the mechanism of the advancing velocity of the working face in coal failure was discussed. The results show that, as the loading rate increases, the peak strength of the sample generally shows an increasing trend, but the elastic modulus changes irregularly. The sample is more prone to local failure before the peak strength. An increase in the loading rate rapidly promotes damage in the sample and accelerates the transition from internal damage to macroscopic failure, with no obvious effect on the ratio of damage threshold to corresponding peak strength. At low loading rates, the samples mainly experienced static failure; the failure form was spalling, and the failure range was wide. At high loading rates, the samples were prone to dynamic failure in the local area, manifested as the ejection of slabs and debris. A greater loading rate produced smaller and thinner slabs and a greater ejection velocity. Properly increasing the advancing velocity of the working face is conducive to reducing spalling to prevent large-area roof fall, but it may increase the possibility of coal burst in local areas. The results of this study provide a reference for roof control and coal burst disaster prevention on the working face in deep coal mining.

A dual-polarized continuous transverse stub (CTS) K-band antenna with reconfigurable four beams and low profile is proposed based on substrate-integrated-waveguide (SIW) design. It consists of a line source generator (LSG) on the bottom surface, a spherical-wave to plane-wave transforming part on the middle layer, and CTS radiators on the top surface. Particularly, the LSG has four SIW-based H-plane horns, and a chip is integrated to switch among the two pairs of horns, so as to transfer the quasi-TEM waves on the bottom surface by a ±10° deflection angle to the middle layer for the CTS radiators on the top surface, resulting in four reconfigurable scanning beams with 10° for two polarizations. The measurements show that it realizes four reconfigurable beams with a 25.8 dBi gain at 24 GHz, verifying the design. The proposed antenna takes into account the advantages of reconfigurable multi-beam, dual polarization, low side lobes, low profile, and high gain, which can be applied to K-band sensing, especially for wind profile radars.

Wind profile radar systems require antennas with multiple radiation beams for detecting wind velocity, as well as with a low sidelobe and dual polarization for enhancing the sensitivity for the weak signal reflected from the turbulence. This paper proposes a lens antenna operating at 24 GHz with four reconfigurable beams for wind profile radars. This lens antenna includes 2 × 2 corrugated horn antennas for radiating 24 GHz waves in two polarizations, and the dielectric lens for modulating four radiation beams with a high gain and low sidelobe. Experiments demonstrate that this lens antenna can realize reconfigurable beams with deflections of ±15° in dual polarizations, meanwhile with the gain of 30.58 dBi and the sidelobe of −20 dB. This proposed lens antenna can be applied to mmWave wind profile radars of wind turbines for enhancing wind power efficiency.

Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by exocrine gland involvement and marked lymphocytic infiltration. Numerous reports of patients with Sjögren’s syndrome have described kidney damage, mainly involving distal tubule dysfunction, severe renal calcification, kidney stones, and rickets. We herein describe a patient with primary Sjögren’s syndrome who developed type I renal tubular acidosis with hypokalemia as the first symptom. This case highlights the possibility that an underlying autoimmune disorder should be considered in a patient presenting with distal tubular acidosis or recurrent hypokalemic periodic paralysis because treatment of the primary disease improves the outcome.

Abstract A team effort to develop a Community Integrated Earth System Model (CIESM) was initiated in China in 2012. The model was based on NCAR Community Earth System Model (Version 1.2.1) with several novel developments and modifications aimed to overcome some persistent systematic biases, such as the double Intertropical Convergence Zone problem and underestimated marine boundary layer clouds. Aerosols' direct and indirect effects are prescribed using the MACv2‐SP approach and data sets. The spin‐up of a 500‐year preindustrial simulation and three historical simulations are described and evaluated. Prominent improvements include alleviated double Intertropical Convergence Zone problem, increased marine boundary layer clouds, and better El Niño Southern Oscillation amplitude and periods. One deficiency of the model is the significantly underestimated Arctic and Antarctic sea ice in warm seasons. The historical warming is about 0.55 °C greater than observations toward 2014. CIESM has an equilibrium climate sensitivity of 5.67 K, mainly resulted from increased positive shortwave cloud feedback. Our efforts on porting and redesigning CIESM for the heterogeneous Sunway TaihuLight supercomputer are also introduced, including some ongoing developments toward a future version of the model.

Intestinal floras influence a lot of biological functions of the organism. Although animal model are strong tools for researches on the relationship between host and microbe, a physiologically relevant in vitro human gut model was still required. Here, a novel human gut-vessel microfluidic system was established to study the host–microbial interaction. Peristaltic motion of the cells on the chip was driven by a pneumatic pump. When intestinal epithelial cells (Caco2) were co-cultured with vascular endothelial cells (HUVECs) on the peristaltic microfluidic chip, Caco2 showed normal barrier and absorption functions after 5 days cultivation, which generally took 21 days in static Transwell models. Intestinal microvilli and glycocalyx layer were seen after 4 days cultivation, and Lactobacillus casei was successfully co-cultured for a week in the intestinal cavity. A model for intestinal damage and inflammatory responses caused by E. coli was set up on this chip, which were successfully suppressed by Lactobacillus casei or antibiotic. In summary, this human gut-vessel microfluidic system showed a good potential for investigating the host–microbial interaction and the effect and mechanism of microbiome on intestinal diseases in vitro.

Abstract Cloud partition between liquid and ice phases and their vertical distributions are crucial to energy budget and global climate. Liquid and ice cloud fractions simulated by Community Atmosphere Model version 5.3 and Cloud Feedback Model Intercomparison Project Observational Simulator Package version 1.4 are evaluated by comparing to satellite retrieval data from Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observation. Model underestimates liquid cloud by 3.3%, 5.5%, and 3.1% and overestimates ice cloud by 1.5%, 6.3%, and 4.6% in high, medium, and low levels, respectively. The misclassification of liquid cloud to ice cloud occurs in all model levels, leading to an overall underestimation of supercooled liquid fraction (SLF) globally and a shift of 50% SLF line from about −20°C in observation to −5°C in model. Specifically, model produces excessive ice cloud in extratropics and insufficient liquid cloud in tropics at mixed‐phase levels with temperature between 0 and −40°C.

Since the discovery of TAR DNA-binding protein 43 (TDP-43) in 1995, our understanding of its role continues to expand as research progresses. In particular, its role in the pathogenesis of Alzheimer’s disease (AD) has drawn increasing interest in recent years. TDP-43 may participate in various pathogenic mechanisms underlying AD, such as amyloid β deposition, tau hyperphosphorylation, mitochondrial dysfunction, and neuroinflammation. Because AD is complex and heterogeneous, and because of the distinct characteristics of TDP-43, mostly seen in the oldest-old and those with more severe clinical phenotype, subcategorization based on specific features or biomarkers may significantly improve diagnosis and treatment. AD-like cognitive dysfunction associated with TDP-43 pathology may therefore be a distinct encephalopathy, referred to as limbic-predominant age-related TDP-43 encephalopathy (LATE).

This systematic review and meta-analysis aimed to evaluate the accuracy of fine-needle aspiration (FNA) and core-needle biopsy (CNB) in diagnosing thyroid cancer. The PubMed, Embase, and Cochrane Library databases were retrieved up to May 2019, and the overall accuracy of FNA and CNB in diagnosing thyroid cancer was evaluated by meta-analysis. The sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were calculated. The summary receiver operating characteristic (ROC) curve was estimated, and the area under the ROC curve (AUC) was calculated. Ten eligible studies, involving 10,078 patients with 10,842 thyroid nodules, were included. The overall sensitivity and specificity of FNA and CNB for thyroid cancer were 0.72 [95 % confidence interval (CI): 0.69–0.74], 0.99 (95% CI: 0.98–0.99), and 0.83 (95% CI: 0.81–0.85), 0.99 (95% CI: 0.98–0.99), respectively. Other parameters used to assess efficacy included PLR 41.71 (2.15–808.27) and 51.56 (3.20–841.47), NLR 0.31 (0.22–0.42) and 0.22 (0.15–0.32), for FNA and CNB, respectively. Overall, the pooled summary ROC (AUC) value of FNA and CNB was 0.9025 and 0.7926, respectively. No significant difference was observed between the two AUCs of FNA and CNB (P = 0.164). FNA and CNB are still similar as first-line diagnostic tools. FNA remains a good first-line method for detecting thyroid malignancies.

Oncolytic viruses represent a promising therapeutic modality, but they have yet to live up to their therapeutic potential. Safety and efficacy concerns impel us to identify least toxic oncolytic agents that would generate durable and multifaceted anti-tumor immune responses to disrupt the tumors. Here we describe a rational engineered oncolytic herpes virus (OVH) that is a selective killer for targeting tumors, has strong safety records, induces complete regression of tumors in multiple tumor models, and elicits potent antitumor immunity. By far, the potential of OVs in promoting the tumor antigen-specific humoral immune responses remains obscure. In this study, we found that effective treatment by OVH induced immunogenic cell death, which facilitates to elicit humoral immune responses. Depletion experiments revealed that B cells were required for maximal antitumor efficacy of oncolytic immunotherapy. Both serum transfer and antibody treatment experiments revealed that endogenous oncolysis-induced antigen-targeting therapeutic antibodies can lead to systemic tumor regression. Our data demonstrate that tumor-targeting immune modulatory properties confer oncolytic OVH virotherapy as potent immunotherapeutic cancer vaccines that can generate specific and efficacious antitumor humoral responses by eliciting endogenous tumor antigen-targeting therapeutic antibodies in situ, resulting in an efficacious and tumor-specific therapeutic effect.

To study the effect of excavation unloading on hard rock failure, a series of true-triaxial compression tests, biaxial compression tests, and true-triaxial unloading compression tests (two different unloading rates) at different confining pressures was conducted on red sandstone cube samples. The strength and failure characteristics and their relationship for red sandstone unloading at different unloading rates and confining pressures were analyzed. Based on the test results, the effects of the unloading rate and confining pressure on the strength and failure characteristics of hard rock were explored, and a reasonable explanation for unloading-induced spalling in hard rock tunnels was presented. The results show the stress-strain curve of highly stressed red sandstone exhibits a stress step during unloading, and the higher the unloading rate, the lower the stress level required for a stress step. The rock strength-weakening effect induced by unloading was confirmed. The mechanical properties of red sandstone become more unstable and complicated after unloading. After the red sandstone is unloaded to a two-dimensional stress state, with increasing confining pressure, the strength increases first and then decreases; the failure mode changes from a low-confining pressure tensile-shear failure to a high-confining pressure tensile failure; and the geometries of the slabs change from large thick plates and wedges to medium- and small-sized thin plates. At equal confining pressures, the higher the unloading rate, the lower the strength (i.e., the strength-weakening effect is more pronounced), the thinner the slab, and the lower the confining pressure required for the failure mode to change from tensile-shear failure to tensile failure. The unloading rate and confining pressure affect the strength and failure characteristics by affecting the crack initiation type and propagation direction in hard rock. For deep hard rock tunnels with high unloading rate and axial stress, neglecting the effects of unloading rate and axial stress will lead to a dangerous support design. For deep hard rock ore, if the maximal horizontal principal stress exceeds the critical confining pressure, the mining surface should be perpendicular to the direction of the minimal horizontal principal stress. The results of this study are of great engineering significance for guiding deep hard rock tunnel construction and mining.

Phosphorus (P) is an essential macronutrient for plant growth and development. The concentration of flavonol, a natural plant antioxidant, is closely related to phosphorus nutritional status. However, the regulatory networks of flavonol biosynthesis under low Pi stress are still unclear. In this study, we identified a PFG-type MYB gene, NtMYB12, whose expression was significantly up-regulated under low Pi conditions. Overexpression of NtMYB12 dramatically increased flavonol concentration and the expression of certain flavonol biosynthetic genes (NtCHS, NtCHI, and NtFLS) in transgenic tobacco. Moreover, overexpression of NtMYB12 also increased the total P concentration and enhanced tobacco tolerance of low Pi stress by increasing the expression of Pht1-family genes (NtPT1 and NtPT2). We further demonstrated that NtCHS-overexpressing plants and NtPT2-overexpressing plants also had increased flavonol and P accumulation and higher tolerance to low Pi stress, showing a similar phenotype to NtMYB12-overexpressing transgenic tobacco under low Pi stress. These results suggested that tobacco NtMYB12 acts as a phosphorus starvation response enhancement factor and regulates NtCHS and NtPT2 expression, which results in increased flavonol and P accumulation and enhances tolerance to low Pi stress.

Objective(s): A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods: In this study, we used the Oncomine™ database to determine the expression patterns of RHBDD1 in normal and breast cancer tissues. We performed lentiviral transfection of RHBDD1-specific small interfering RNA into the breast cancer cell lines ZR-75-30 and MDA-MB-231 in order to investigate the effects of RHBDD1 deficiency on breast cancer metastasis. Results: We found that knockdown of RHBDD1 inhibited breast cancer cell migration and invasion in vitro. Moreover, knockdown of RHBDD1 promoted epithelial–mesenchymal transition (EMT) by suppressing the expression of MPP2, MPP9, fibronectin 1, vimentin, SRY-box 2, zinc finger E-box binding homeobox 1, and snail family transcriptional repressor 1, and promoting the expression of cadherin 1. Additionally, knockdown of RHBDD1 inhibited the protein expression and phosphorylation of Akt.Conclusion: Our data indicate that RHBDD1 overexpression may promote breast cancer metastasis via the regulation of EMT, suggesting that RHBDD1 may be an important regulator of breast cancer metastasis.

Abstract Background Myocardial fibrosis is a common pathophysiological process that is related to ventricular remodeling in congenital heart disease. However, the presence, characteristics, and clinical significance of myocardial fibrosis in Ebstein’s anomaly have not been fully investigated. This study aimed to evaluate myocardial fibrosis using cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) and T1 mapping techniques, and to explore the significance of myocardial fibrosis in adolescent and adult patients with Ebstein’s anomaly. Methods Forty-four consecutive patients with unrepaired Ebstein’s anomaly (34.0 ± 16.2 years; 18 males), and an equal number of age- and gender-matched controls, were included. A comprehensive CMR protocol consisted of cine, LGE, and T1 mapping by modified Look-Locker inversion recovery (MOLLI) sequences were performed. Ventricular functional parameters, native T1, extracellular volume (ECV), and LGE were analyzed. Associations between myocardial fibrosis and disease severity, ventricular function, and NYHA classification were analyzed. Results LGE was found in 10 (22.7%) patients. Typical LGE in Ebstein’s anomaly was located in the endocardium of the septum within the right ventricle (RV). The LV ECV of Ebstein’s anomaly were significantly higher than those of the controls (30.0 ± 3.8% vs. 25.3 ± 2.3%, P

Background Icaritin (ICT) is a prenylflavonoid derivative from Epimedium brevicornum Maxim. ICT has been shown to have neuroprotective effects. We investigate how ICT affects secretion of amyloid precursor protein (APP). Methods We exposed APP-PS1-HEK293 cells to ICT to investigate its effect on beta-site amyloid cleaving enzyme (BACE)1. Cell viability was evaluated by MTT and lactate dehydrogenase (LDH) assays. The half-maximal inhibitory concentration (IC50) of ICT for BACE1 was measured using fluorescence resonance energy transfer. Effects of ICT on the mRNA expression of APP were assessed by quantitative polymerase chain reaction, and protein expression was measured by western blotting and immunofluorescence. Results Icaritin inhibited BACE1 activity and IC50 was 5.70 ± 1.09 μM. Compared with the control group, at ICT concentrations of 5 μM and 10 μM, the viability increased and LDH leakage decreased in APP-PS1-293 cells. Also, mRNA expression of A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) increased, while that of BACE1 and presenilin-1 (PS1) decreased, upon ICT treatment. Western blotting and immunofluorescence confirmed that protein expression of ADAM10, BACE1 and PS1 showed the same trend. Expression of the APP fragments sAPPβ and C-terminal fragment β decreased, while that of sAPPα increased, upon ICT treatment. Expression of amyloid β peptides in APP-PS1-HEK293 cells was lower in ICT-treated groups compared with that in the control group. Conclusions Icaritin, as a BACE1 inhibitor, inhibits APP secretion in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway.

Alternaria late blight (ALB), caused mainly by the fungal pathogen Alternaria alternata, is an important pistachio disease that causes severe tree defoliation and fruit shell staining. Its control relies on multiple fungicide sprays, including carboxamide fungicides. In 2015, we surveyed 35 orchards representing nine pistachio producing counties of California to determine the current situation of Alternaria resistance to four widely used carboxamide fungicide active ingredients. This survey showed that isolates collected in the northern (Tehama, Glenn and Colusa counties) and southern (Tulare, Kings and Kern counties) Central Valley presented higher frequencies of carboxamide resistance than isolates collected from orchards in the central region (Fresno, Madera and Merced counties). The number of carboxamide usages in a year is the main factor determining elevated resistance. By extracting the A. alternata DNA and sequencing the carboxamide target genes, we evaluated the prevalence of specific molecular alterations (mutations) associated with carboxamide fungicide resistance. Finally, we identified cross-resistance patterns among different carboxamide fungicides, leading to recommendations about combinations to avoid.

Abstract Background To assess the oncologic outcomes of radiation therapy (RT) combined with maximal androgen blockade (MAB) and prostate-specific antigen (PSA) kinetics in patients with localized, high-risk prostate carcinoma (PCa). Methods Three-hundred twenty individuals with localized PCa who underwent RT + MAB in 2001–2015 were evaluated retrospectively. All patients had received 36 months of MAB therapy and 45 Gy of pelvic irradiation, plus a dose-escalated external beam radiation therapy (DE-EBRT) boost to 76~81 Gy (MAB + EBRT group), or a low-dose-rate prostate permanent brachytherapy (LDR-PPB) boost to 110 Gy with I-125 (MAB + EBRT + PPB group). Results Follow-up median is 90 months, ranging from 12 to 186 months; 117 (36.6%) and 203 (63.4%) cases underwent MAB + EBRT and MAB + EBRT + PPB, respectively. Multivariate Cox regression showed that the PPB regimen and PSA kinetics were positive indicators of oncologic outcomes. Compared with MAB + EBRT, MAB + EBRT + PPB remarkably improved PSA kinetics more pronouncedly: PSA nadir (1.3 ± 0.7 vs 0.11 ± 0.06 ng/mL); time of PSA decrease to nadir (7.5 ± 1.8 vs 3.2 ± 2.1 months); PSA doubling time (PSADT; 15.6 ± 4.2 vs 22.6 ± 6.1 months); decrease in PSA (84.6 ± 6.2% vs 95.8 ± 3.4%). Additionally, median times of several important oncologic events were prolonged in the MAB + EBRT + PPB group compared with the MAB + EBRT group: overall survival (OS; 12.3 vs 9.1 years, P

Abstract Background Ischemic stroke-induced neuroinflammation is mainly mediated by microglial cells. The nuclear factor kappa B (NF-κB) pathway is the key transcriptional pathway that initiates inflammatory responses following cerebral ischemia. OTULIN, a critical negative regulator of the NF-κΒ signaling pathway, exerts robust effects on peripheral immune cell-mediated inflammation and is regarded as an essential mediator for repressing inflammation in vivo. The effect of OTULIN on inflammatory responses in the central nervous system (CNS) was previously unstudied. This current study investigated the anti-inflammatory effect of OTULIN both in vitro and in vivo in ischemic stroke models. Methods Sprague-Dawley (SD) rats were subjected to transient middle cerebral artery occlusion (tMCAO) or an intraperitoneal injection of lipopolysaccharide (LPS). Overexpression of the OTULIN gene was utilized to observe the effect of OTULIN on ischemic stroke outcomes. The effect of OTULIN overexpression on microglia-mediated neuroinflammation was examined in rat primary microglia (PM) and in the microglial cell line N9 after induction by oxygen-glucose deprivation (OGD)-treated neuronal medium. The activation and inflammatory responses of microglia were detected using immunofluorescence, ELISA, and qRT-PCR. The details of molecular mechanism were assessed using Western blotting. Results In the tMCAO rats, the focal cerebral ischemia/reperfusion injury induced a continuous increase in OTULIN expression within 72 h, and OTULIN expression was increased in activated microglial cells. OTULIN overexpression obviously decreased the cerebral infarct volume, improved the neurological function deficits, and reduced neuronal loss at 72 h after reperfusion, and it also inhibited the activation of microglia and attenuated the release of TNF-α, IL-1β, and IL-6 by suppressing the NF-κB pathway at 24 h after tMCAO. In vitro, OTULIN overexpression inhibited the microglia-mediated neuroinflammation by reducing the production of TNF-α, IL-1β, and IL-6 via depressing the NF-κB pathway in both PM and N9 cells. Conclusions OTULIN provides a potential therapeutic target for ischemic brain injury by ameliorating the excessive activation of microglial cells and neuroinflammation through repressing the NF-κB signaling pathway.

A 12-port antenna array operating in the long term evolution (LTE) band 42 (3400-3600 MHz), LTE band 43 (3600-3800 MHz), and LTE band 46 (5150-5925 MHz) for 5G massive multiple-input multiple-output (MIMO) applications in mobile handsets is presented. The proposed MIMO antenna is composed of three different antenna element types, namely, inverted π-shaped antenna, longer inverted L-shaped open slot antenna, and shorter inverted L-shaped open slot antenna. In total, eight antenna elements are used for the 8×8 MIMO in LTE bands 42/43, and six antenna elements are designed for the 6×6 MIMO in LTE band 46. The proposed antenna was simulated, and a prototype was fabricated and tested. The measured results show that the LTE bands 42/43/46 are satisfied with reflection coefficient better than -6 dB, isolation lower than -12 dB, and total efficiencies of higher than 40%. In addition to that, the proposed antenna array has also shown good MIMO performances with an envelope correlation coefficient lower than 0.15, and ergodic channel capacities higher than 34 and 26.5 b/s/Hz in the LTE bands 42/43 and LTE band 46, respectively. The hand phantom effects are also investigated, and the results show that the proposed antenna array can still exhibit good radiation and MIMO performances when operating under data mode and read mode conditions.

A multi-band 10-antenna array working at the sub-6-GHz spectrum (LTE bands 42/43 and LTE band 46) for massive multiple-input multiple-output (MIMO) applications in future 5G smartphones is proposed. To realize 10 × 10 MIMO applications in three LTE bands, 10 T-shaped coupled-fed slot antenna elements that can excite dual resonant modes are integrated into a system circuit board. Spatial and polarization diversity techniques are implemented on these elements so that the improved isolation and mitigated coupling effects can be achieved. The proposed antenna array was manufactured and experimentally measured. Desirable antenna efficiencies of higher than 42% and 62% were measured in the low band and high band, respectively. Vital results, such as the envelope correlation coefficient, channel capacity, and mean effective gain ratio, have also been computed and analyzed. The calculated ergodic channel capacities of the 10 × 10 MIMO system working in the LTE bands 42/43 and LTE band 46 reached up to 48 and 51.4 b/s/Hz, respectively.

The title of data scientist has been described as one of the sexiest jobs of the 21st century. Numerous efforts have been made to define the job of a data scientist in a qualitative manner by, for example, listing the job functions and required skill sets of data scientists. However, to the best of our knowledge, no attempt has been made to define the term data scientist in a scientific manner. In this paper, we address this issue by using a data-driven approach to answer three questions: (1) What is a proper definition of the term data scientist from a market-demand perspective? (2) Do self-described data scientists meet the market demand? and (3) Finally, how can companies efficiently recruit data scientists that match their openings? To answer these questions, we crawl two data sets for the supply and demand sides. For the former, we collect a set of data scientist user profiles from LinkedIn; for the latter, we collect a set of data scientist job descriptions from Monster. We first parse the set of data scientist job descriptions via natural language processing techniques and derive a scientific definition of the job of a data scientist via a clustering algorithm. Second, we use the same approach to determine that, under the aforementioned definition, self-claimed data scientists on the market would meet the market demand with a high probability. Finally, we introduce a distance-metric learning approach that can be used by companies to find data scientist candidates that match their openings. We achieve an average precision of 12.31%; i.e., one in ten candidates with matching qualifications would accept a given offer. The application of this quantitative approach could significantly reduce the human-resource costs incurred by companies in recruiting matching data scientists.

Surface defect detection for printed circuit board (PCB) is indispensable for managing PCB production quality. However, automatic detection of PCB surface defects is still a challenging task because, even within the same category of surface defect, defects present great differences in morphology and pattern. Although many computer vision-based detectors have been established to handle these problems, current detectors struggle to achieve high detection accuracy, fast detection speed and low memory consumption simultaneously. To address those issues, we propose a cost-effective deep learning (DL)-based detector based on the cutting-edge YOLOv4 to detect PCB surface defect quickly and efficiently. The YOLOv4 is improved upon with respect to its backbone network and the activation function in its neck/prediction network. The improved YOLOv4 is evaluated with a customized dataset, collected from a PCB factory. The experimental results show that the improved detector achieved a high performance, scoring 98.64% on mean average precision (mAP) at 56.98 frames per second (FPS), outperforming the other compared SOTA detectors. Furthermore, the improved YOLOv4 reduced the parameter space of YOLOv4 from 63.96 M to 39.59 M and the number of multiply-accumulate operations (Madds) from 59.75 G to 26.15 G.

The phytochrome-interacting factors (PIFs) proteins belong to the subfamily of basic helix–loop–helix (bHLH) transcription factors and play important roles in chloroplast development and chlorophyll biosynthesis. Currently, knowledge about the PIF gene family in Camellia sinensis remains very limited. In this study, seven PIF members were identified in the C. sinensis genome and named based on homology with AtPIF genes in Arabidopsis thaliana. All C. sinensis PIF (CsPIF) proteins have both the conserved active PHYB binding (APB) and bHLH domains. Phylogenetic analysis revealed that CsPIFs were clustered into four groups—PIF1, PIF3, PIF7, and PIF8—and most CsPIFs were clustered in pairs with their corresponding orthologs in Populus tremula. CsPIF members in the same group tended to display uniform or similar exon–intron distribution patterns and motif compositions. CsPIF genes were differentially expressed in C. sinensis with various leaf colors and strongly correlated with the expression of genes involved in the chlorophyll metabolism pathway. Promoter analysis of structural genes related to chlorophyll metabolism found DNA-binding sites of PIFs were abundant in the promoter regions. Protein–protein interaction networks of CsPIFs demonstrated a close association with phytochrome, PIF4, HY5, TOC1, COP1, and PTAC12 proteins. Additionally, subcellular localization and transcriptional activity analysis suggested that CsPIF3b was nuclear localized protein and possessed transcriptional activity. We also found that CsPIF3b could activate the transcription of CsHEMA and CsPOR in Nicotiana benthamiana leaves. This work provides comprehensive research of CsPIFs and would be helpful to further promote the regulation mechanism of PIF on chlorophyll metabolism in C. sinensis.

Excessive exploitation of the groundwater has resulted in obvious three-dimensional (3D) deformation features on the surface of the Beijing Plain. This paper, by combining Interferometric Synthetic Aperture Radar (InSAR) and Global Positioning System (GPS) technologies, has obtained time-series information of the 3D surface deformation in the Beijing Plain, analyzing its spatial distribution characteristics. On this basis, the relationship between different controlling factors with the 3D deformation of the surface has been analyzed as well. The following results are obtained: (1) From 2013 to 2018, the land subsidence, which generally showed the trend of slowing down, was mainly concentrated in the eastern, northern, and southern regions of Beijing Plain, with multiple subsidence centers. (2) Under the International Terrestrial Reference Frame 2005 (ITRF2005), the horizontal direction of all GPS points in the plain is basically the same, with the dominant movement direction being NE112.5°~NE113.8°. Under the Eurasian reference frame, the horizontal movement rate of GPS points significantly decreases. The movement rate and direction of each point are not characteristic of overall trend activity. (3) The distribution and extent of the 3D surface deformation in the Beijing Plain are controlled by the basement structure. Part of the subsided area corresponds to a Quaternary depression formed at the junction of active faults disrupting the area. Similarly, the distribution of horizontal deformation in the E-W and N-S directions of the plain is controlled by the regional basement structure comprising major faults bounding horizontal deformation. (4) Groundwater exploitation is the main cause of the 3D surface deformation in the Beijing Plain. The groundwater funnels of the second and third confined aquifer are in suitable agreement with the land subsidence. The horizontal movement in the Beijing Plain is either directed toward the center of the groundwater or the land subsidence funnel, and the deformation is directed from areas with higher to areas with lower groundwater levels.

The pathogenesis of respiratory diseases is complex, and its occurrence and development also involve a series of pathological processes. The present research methods are have difficulty simulating the natural developing state of the disease in the body, and the results cannot reflect the real growth state and function in vivo. The development of microfluidic chip technology provides a technical platform for better research on respiratory diseases. The size of its microchannel can be similar to the space for cell growth in vivo. In addition, organ-on-a-chip can achieve long-term co-cultivation of multiple cells and produce precisely controllable fluid shear force, periodically changing mechanical force, and perfusate with varying solute concentration gradient. To sum up, the chip can be used to analyze the specific pathophysiological changes of organs meticulously, and it is widely used in scientific research on respiratory diseases. The focus of this review is to describe and discuss current studies of artificial respiratory systems based on organ-on-a-chip technology and to summarize their applications in the real world.

A key problem in the field of quantum computing is understanding whether quantum machine learning (QML) models implemented on noisy intermediate-scale quantum (NISQ) machines can achieve quantum advantages. Recently, Huang et al. [Nat Commun 12, 2631] partially answered this question by the lens of quantum kernel learning. Namely, they exhibited that quantum kernels can learn specific datasets with lower generalization error over the optimal classical kernel methods. However, most of their results are established on the ideal setting and ignore the caveats of near-term quantum machines. To this end, a crucial open question is: does the power of quantum kernels still hold under the NISQ setting? In this study, we fill this knowledge gap by exploiting the power of quantum kernels when the quantum system noise and sample error are considered. Concretely, we first prove that the advantage of quantum kernels is vanished for large size of datasets, few number of measurements, and large system noise. With the aim of preserving the superiority of quantum kernels in the NISQ era, we further devise an effective method via indefinite kernel learning. Numerical simulations accord with our theoretical results. Our work provides theoretical guidance of exploring advanced quantum kernels to attain quantum advantages on NISQ devices.

Abstract Background Given the important roles of the receptor-mediated lysophosphatidic acid (LPA) signaling in both reproductive tract function and gynecological cancers, it will be informative to investigate the potential role of LPA in the development of adenomyosis. The objective of this study was to evaluate the levels of LPA in plasma and the expression of six LPA receptors in the endometrial tissue collected from women with and without adenomyosis. Methods Plasma and endometrial tissue samples were collected form women with and without adenomyosis. The levels of LPA in plasma were determined by using high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Immunohistochemistry was performed to evaluate the expression of six LPA receptors (LPA1–6) in endometrial tissue samples. The effects of LPA on IL-8 production, VEGF production and cell proliferation in human endometrial stromal cells (ESCs) were also assessed. Results LPA1 staining was localized to the cytoplasm, membrances of the epithelial cells of the endometrial glands, and there was little staining in the stromal cells. LPA2–5 staining were localized to the nuclei of stromal and glandular cells. Plasma levels of LPA were increased in adenomyosis. LPA1, LPA4 and LPA5 immunoreactivity were significantly higher in the adenomyosis group than in the control group, while LPA2 and LPA3 immunoreactivity were significantly lower in the adenomyosis group than in the control group. LPA6 was undetectable in the endometria. LPA induced the release of IL-8 from ESCs but did not affect cell proliferation and VEGF production. Conclusion These results indicate that elevated plasma levels of LPA and aberrant expression of LPA receptors in the endometria may be associated with the development of adenomyosis.

Abstract Background Radiation for Graves’ ophthalmopathy (GO) has traditionally utilized lateral opposing fields (LOF) or three-dimensional conformal radiotherapy (3DCRT) technique. The current study was conducted to report clinical outcomes and therapeutic effects of intensity modulated radiation therapy (IMRT) in treating GO patients. Methods One hundred sixteen patients with GO were treated with IMRT as initial local therapy between July 2010 and August 2013, with a median follow-up of 62 months (range 45–81 months). Radiotherapy dose was 20 Gy in 10 fractions within two to three weeks. The immediate and long-term response to IMRT was evaluated in GO severity score and in each category of symptoms. Acute and long-term complications were recorded to assess its safety. Results Symptom severity score significantly fell from the start of treatment to 4- or 6- month post-IMRT (P

Reliable and accurate facial skin extraction is the most critical and urgent issue for adaptive skin detection. Aiming at resolving this issue, the authors propose an adaptive skin detection method using face location and facial structure estimation. The face location algorithm is developed to improve the reliability of face detection and extract a face region with a high proportion of skin. Facial structure estimation is exploited to further reduce the impact of non‐skin factors on dynamic skin colour modelling. The colour space distribution model of extracted facial skin is very close to that of real facial skin. Finally, the skin in an image is obtained by using a hybrid colour space strategy. Extensive experimental comparisons with some state‐of‐the‐art methods have shown the superior performance of the proposed method.

Climate models repeatedly show a warm and dry bias over the central United States, but the origin of this bias remains unclear. Here the authors associate this bias to precipitation deficits in models and after applying a correction, projected precipitation in this region shows no significant changes.

Abstract Background Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investigate the association of circulating ZAG with metabolic syndrome (MetS) in middle-aged and older Chinese adults. Methods Four hundred eighty nine individuals (234 healthy controls and 255 MetS patients) were examined. All individuals were screened for MetS according to the diagnostic guidelines of the United States National Cholesterol Education Program (NCEP) Expert Panel Adult Treatment Panel (ATP) III criteria. Circulating ZAG and ADI levels were measured by ELISA. Blood fat, glucose and insulin were measured with a commercial kit. Circulating ZAG levels were compared with various parameters in study subjects. Results Plasma ZAG levels were lower in MetS patients compared to those of the healthy controls (35.0 ± 11.7 vs. 46.1 ± 18.6 mg/L, P

This paper addresses the impact of climate change on the water cycle and resource changes in the Eastern Monsoon Region of China (EMRC). It also represents a summary of the achievements made by the National Key Basic Research and Development Program (2010CB428400), where the major research focuses are detection and attribution, extreme floods and droughts, and adaptation of water resources management. Preliminary conclusions can be summarized into four points: 1) Water cycling and water resource changes in the EMRC are rather complicated as the region is impacted by natural changes relating to the strong monsoon influence and also by climate change impacts caused by CO2 emissions due to anthropogenic forcing; 2) the rate of natural variability contributing to the influence on precipitation accounts for about 70%, and the rate from anthropogenic forcing accounts for 30% on average in the EMRC. However, with future scenarios of increasing CO2 emissions, the contribution rate from anthropogenic forcing will increase and water resources management will experience greater issues related to the climate change impact; 3) Extreme floods and droughts in the EMRC will be an increasing trend, based on IPCC-AR5 scenarios; 4) Along with rising temperatures of 1 °C in North China, the agricultural water consumption will increase to about 4% of total water consumption. Therefore, climate change is making a significant impact and will be a risk to the EMRC, which covers almost all of the eight major river basins, such as the Yangtze River, Yellow River, Huaihe River, Haihe River, and Pearl River, and to the South-to-North Water Diversion Project (middle line). To ensure water security, it is urgently necessary to take adaptive countermeasures and reduce the vulnerability of water resources and associated risks.

Abstract The size and function of the left atrium (LA) and right atrium (RA) are related closely with the prognosis of cardiovascular diseases. However, their normal reference values, as measured by cardiac magnetic resonance (CMR), are not well established in Chinese populations. Healthy Chinese subjects (n = 135, 66 males, age 23–83 years) without cardiovascular risk factors were recruited. We imaged the LA and RA of all subjects using short axis and long axis slices by steady-state free precession (SSFP) sequences using a 3.0T scanner. The size and functional parameters were measured. Age and gender differences in LA were further explored. The normal reference values of atrial dimensions, volumes, and empty fractions (EFs) were provided by short axis (SAX) and area-length methods. Volumes and EFs derived by the area-length method showed correlated well with those derived by the by SAX method, but significantly underestimated the volumes (all P

A practical method using single-shot ptychographic imaging (SPI) in the transform domain is proposed for multiple-image hiding. The excellent compressibility of SPI can bring high multiplexing capacity and imperceptibility to the proposed multiple-image hiding system. The security is mainly supported by the imperceptibility and the large quantity of scrambling modes, and security will be improved greatly with the increase of hidden images. Furthermore, the successful combination with the discrete cosine transform-domain algorithm can not only further enhance the imperceptibility and security but indicates that SPI-based multiple-image hiding is compatible with transform domain algorithms as well. Optical experiments demonstrate the high feasibility, multiplexing capacity, imperceptibility, and security of the proposed technique. The proposed method may open up a novel research perspective for multiple-image hiding combined with various efficient transform domain algorithms.

Objective To investigate the effects of Huang Qin Hua Shi (HQ) decoction on the hypothalamic–pituitary–adrenal (HPA) axis in rats under high-temperature (hT)- and high-humidity (hH)-induced stress. Methods Male rats were randomized into four groups: rats without stress; rats induced with hT (35 ± 1°C) and hH (85 ± 5% humidity); rats induced with hT and hH and treated with HQ decoction; and rats induced with hT and hH and treated with mifepristone. After 3 weeks, rats underwent the Morris water maze and open-field test. Rat hypothalami were analyzed pathologically using hematoxylin and eosin staining and glucocorticoid receptor (GR) mRNA expression was evaluated by in situ hybridization. Serum levels of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosteroid (CORT) were assessed by enzyme-linked immunosorbent assay. Results The administration of mifepristone or HQ in stressed rats significantly improved their performance in the Morris water maze test and increased the central-to-peripheral ratio and incidence of deep rearing in the open-field test. Mifepristone and HQ also reversed histological changes in the hypothalami of stressed rats. Compared with control rats, GR mRNA expression in the hypothalamus and serum CRH, ACTH, and CORT were significantly elevated in rats stressed with hT and hH, and these changes were attenuated by mifepristone and HQ. Conclusion HQ decoction protects against hT- and hH-induced cognitive-behavioral disorder and its therapeutic effect is associated with decreased HPA axis activity.

Multiple system atrophy (MSA) is the most rapidly progressive neurodegenerative disorder among the various types of synucleinopathies. The cause of MSA remains unknown, but it can involve the extrapyramidal system, the pyramidal system, the autonomic nerves and the cerebellum. The main clinical manifestations are Parkinson's symptoms, cerebellar ataxia, pyramidal tract signs and autonomic nervous system disorders. Depending on the initial predominant motor deficits, MSA is subclassified into either Parkinsonian type (MSA-P) or cerebellar type (MSA-C). MSA is rare in the Zunyi area of Guizhou Province, so when it is observed for the first time it often results in a convoluted diagnosis and treatment process, which takes a lot of time, money, manpower and material resources, which can also have a psychological impact on the patient. This report describes the case of a 60-year-old woman who presented with syncope for 1 year combined with dizziness for 1 day. She had been diagnosed twice with transient ischaemic attack in the previous 6 months. Cranial magnetic resonance imaging suggested widening of the cerebellar sulcus and mild cerebellar atrophy. Based on the patient’s medical history, physical signs and auxiliary examinations, she was diagnosed with MSA-C.

The lipopolysaccharide O-antigen structure expressed by the European Helicobacter pylori model strain G27 encompasses a trisaccharide, an intervening glucan-heptan and distal Lewis antigens that promote immune escape. However, several gaps still remain in the corresponding biosynthetic pathway. Here, systematic mutagenesis of glycosyltransferase genes in G27 combined with lipopolysaccharide structural analysis, uncovered HP0102 as the trisaccharide fucosyltransferase, HP1283 as the heptan transferase, and HP1578 as the GlcNAc transferase that initiates the synthesis of Lewis antigens onto the heptan motif. Comparative genomic analysis of G27 lipopolysaccharide biosynthetic genes in strains of different ethnic origin revealed that East-Asian strains lack the HP1283/HP1578 genes but contain an additional copy of HP1105 and JHP0562. Further correlation of different lipopolysaccharide structures with corresponding gene contents led us to propose that the second copy of HP1105 and the JHP0562 may function as the GlcNAc and Gal transferase, respectively, to initiate synthesis of the Lewis antigen onto the Glc-Trio-Core in East-Asian strains lacking the HP1283/HP1578 genes. In view of the high gastric cancer rate in East Asia, the absence of the HP1283/HP1578 genes in East-Asian H. pylori strains warrants future studies addressing the role of the lipopolysaccharide heptan in pathogenesis.

Macrophage activation syndrome (MAS) is a rare and severe complication of Kawasaki disease (KD). The clinical feature, early diagnosis and treatment options, and prognosis need to be further determined in patients with KD complicated with MAS. In this report, we retrospectively analyzed three KD patients complicated with MAS who were treated in pediatric intensive care units (PICU) and reviewed the relevant literatures. We find that being male, being age over 2 years old, incomplete KD, intravenous immunoglobulin (IVIG) non-responder, or persistent fever greater than 10 days are all highly associated with occurrence of MAS. Additional work-ups should be performed promptly in patient with above predisposing factors to rule out complication of MAS. Patients with KD complicated with MAS are at a higher risk of having coronary artery involvement or aneurysm formation, which can be reversed with timely treatment. Early identification and prompt treatment are key points for improving the prognosis of KD patients complicated with MAS.

Chronic obstructive pulmonary disease (COPD) often causes diaphragm dysfunction, which is the main contributor to neuro-muscular respiratory failure and associated with the prognosis of COPD. However, the morphological changes in diaphragm during the development of COPD are complicated and underlying mechanisms have not been absolutely elucidated. Considering smoking is one of the most leading and important risk factors for development of COPD, we set out to investigate the effects of smoking on muscle fibre remodeling and underlying mechanisms in diaphragms. Rats were randomly exposed to cigarette smoke (CS) for one of three durations of 4, 8, and 12 weeks. CS exposure resulted in increased percentage of type I muscle fibres, enhanced apoptosis index, endoplasmic reticulum (ER) dilation, elevated expression of glucose-regulated protein 78, C/EBP homologous protein, caspase-12, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), cytochrome c oxidase 4, Sdhb, p53 and a reduction in fibre diameters in rat diaphragms. The results indicated that CS exposure induced a shift to muscle fibres with aerobic metabolism in predominance in rat diaphragms, which may be dependent on the regulation of PGC-1α and p53. Additionally, ER stress (ERS) associated apoptosis may contribute to the pathogenesis of diaphragmatic muscle atrophy induced by CS exposure.

Objective Early hematoma growth is a major determinant of early neurological deterioration and poor clinical outcome in patients with spontaneous intracerebral hemorrhage (ICH). Inflammation plays a major role in the pathophysiology of ICH. This study aimed to evaluate the potential of the neutrophil-to-lymphocyte ratio (NLR) for predicting early hematoma growth after ICH. Methods A retrospective review was performed of patients with acute spontaneous ICH who were admitted to the Stroke Center of the First People’s Hospital of Jingmen between January 2014 and January 2017. The NLR was computed from admission blood work. Brain computed tomography scans were performed at admission and repeated within 24 hours. Hematoma growth was defined as absolute growth >6 mL or relative growth >33%. Results A total of 123 patients were included and early hematoma growth occurred in 30 (24%) patients. Multivariate analysis showed that the NLR (odds ratio, 1.22; 95% confidence interval, 1.09–1.38) was independently associated with early hematoma growth. The best predictive cut-off of the NLR for early hematoma growth was 6.49 (sensitivity, 50%; specificity, 69%). Conclusions A high NLR is independently predictive of early hematoma growth and may aid in risk stratification of patients with ICH on admission.

Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. In recent years, it has been found that IDH mutations are closely related to the occurrence and development of glioma, and it is a notable potential therapeutic target. First, IDH mutations can produce high levels of 2-hydroxyglutaric acid (2-HG), thereby inhibiting glioma stem cell differentiation. At the same time, IDH mutations can upregulate vascular endothelial growth factor (VEGF) to promote the formation of the tumor microenvironment. In addition, IDH mutations can also induce high levels of hypoxia-inducible factor-1α (HIF-1α) to promote glioma invasion. Ultimately, these changes will lead to the development of glioma. Currently, a large number of IDH inhibitors and vaccines have entered clinical trials, representing progress in the treatment of glioma patients.

Insulin antibody (IA) may potentially affect a patient’s glycemic control due to its variability in both binding and/or releasing insulin. However, the association between IA titer and daily glycemic variability (GV) is still unknown. We thus performed this cross-sectional, retrospective case-control study to assess the relationship between IA titer and mean amplitude glycemic excursion (MAGE) in type 2 diabetes mellitus (T2DM) patients using a continuous glucose monitoring (CGM) system. We recruited 100 eligible patients (IA>5%, IA positive) and divided them into two groups—a low (L) group and a high (H) group—based on their IA titer. The control (C) group consisted of 47 patients (IA≤5%, IA negative) matched for age, BMI, gender, and glycosylated hemoglobin A1c (HbA1c). The CGM determined the GV of enrolled patients. The primary outcome was the relationship between the IA titer and the MAGE, and the secondary outcome was the differences of GV among the three groups. We found that patients in the H group had higher levels of blood glucose fluctuation parameters than those in the L and C groups. The Ln(IA) was positively correlated with Ln(MAGE) even after adjusting for age, gender, BMI, HbA1c, and fasting and postprandial C-peptide(r=0.423, p

For global optimal control strategy, it is not only necessary to know the driving cycle in advance but also difficult to implement online because of its large calculation volume. As an artificial intelligent-based control strategy, reinforcement learning (RL) is applied to an energy management strategy of a super-mild hybrid electric vehicle. According to time-speed datasets of sample driving cycles, a stochastic model of the driver’s power demand is developed. Based on the Markov decision process theory, a mathematical model of an RL-based energy management strategy is established, which assumes the minimum cumulative return expectation as its optimization objective. A policy iteration algorithm is adopted to obtain the optimum control policy that takes the vehicle speed, driver’s power demand, and state of charge (SOC) as the input and the engine power as the output. Using a MATLAB/Simulink platform, CYC_WVUCITY simulation model is established. The results show that, compared with dynamic programming, this method can not only adapt to random driving cycles and reduce fuel consumption of 2.4%, but also be implemented online because of its small calculation volume.

Giant left atrium is a condition characterized by an extreme enlargement of the left atrium with a diameter more than 80 mm and it is usually associated with long standing rheumatic mitral valve disease. We present a case of giant left atrium with massive calcification in a female patient who had a history of rheumatic heart disease, severe mitral stenosis, permanent atrial fibrillation, and cerebral infarctions. Keywords: Giant left atrium, Calcification, Case report

Metamaterial antennas consisting of periodical units are suitable for achieving tunable properties by employing active elements to each unit. However, for compact metamaterials with a very limited number of periodical units, resonance blindness exists. In this paper, we introduce a method to achieve continuous tuning without resonance blindness by exploring hence, taking advantage of nonlinear properties of PIN diodes. First, we obtain the equivalent impedance of the PIN diode through measurements, then fit these nonlinear curves with mathematical expressions. Afterwards, we build the PIN diode model with these mathematical equations, making it compatible with implementing co-simulation between the passive electromagnetic model and the active element of PIN diodes and, particularly, the nonlinear effects can be considered. Next, we design a compact two-unit metamaterial antenna as an example to illustrate the electromagnetic co-simulation. Finally, we implement the experiments with a micro-control unit to validate this method. In addition, the nonlinear stability and the supplying voltage tolerance of nonlinear states for both two kinds of PIN diodes are investigated as well. This method of obtaining smooth tuning with nonlinear properties of PIN diodes can be applied to other active devices, if only PIN diodes are utilized.