1,010 results on '"Xueyan Li"'
Search Results
202. New insight into enhanced photocatalytic selectivity of g-C3N4 by nitrogen vacancy introduction: Experimental study and theoretical calculation
- Author
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Xueyan, Li, primary, Guanlong, Wang, additional, Chenrui, Lan, additional, Xiaoli, Dong, additional, and Xiufang, Zhang, additional
- Published
- 2022
- Full Text
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203. Hydrogen sulfide inhibits lipopolysaccharide-based neuroinflammation-induced astrocyte polarization after cerebral ischemia/reperfusion injury
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Xueyan Li, Xiaojiao Yin, Jiazhuang Pang, Zhiwu Chen, and Jiyue Wen
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Pharmacology - Published
- 2023
204. Electrocatalytic dechlorination of aqueous trichloroacetic acid by Vitamin B12 modified iron electrode
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Xiaoyan Ma, Sinong Huang, Yuhong Jin, Hang Jiang, Liangjie Tang, Yifei Wu, Yongjiong Ni, Shijun Zhu, Xueyan Li, and Andrea M. Dietrich
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Process Chemistry and Technology ,Chemical Engineering (miscellaneous) ,Pollution ,Waste Management and Disposal - Published
- 2023
205. Selective activation of peroxymonosulfate govern by B-site metal in delafossite for efficient pollutants degradation: Pivotal role of d orbital electronic configuration
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Ying Zhao, Shixuan Chen, Hang Qie, Shishu Zhu, Changyong Zhang, Xueyan Li, Wei Wang, Jun Ma, and Zhiqiang Sun
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Environmental Engineering ,Ecological Modeling ,Pollution ,Waste Management and Disposal ,Water Science and Technology ,Civil and Structural Engineering - Published
- 2023
206. Fe2P nanoparticle-decorated porous biochar for high-efficiency electrosynthesis of ammonia from toxic nitrite
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Jiao Hu, Tiantian Zhao, Hua Zhang, Xueyan Li, Anxian Shi, Xue Li, Quan Wang, and Guangzhi Hu
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General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
207. A New Time-Window Prediction Model For Traumatic Hemorrhagic Shock Based on Interpretable Machine Learning
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Li Tanshi, Hongxin Wang, Wei Chen, Guo Xin, Zhaohong Wang, Jing Li, Yuzhuo Zhao, Xiucheng Li, Cong Feng, Lijing Jia, Zijian Wei, Zheyuan Yu, Jiaming Wang, Heng Zhang, Hui Han, Shuxiao Pan, Xueyan Li, and Ruiqi Jia
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Male ,systolic blood pressure ,Computer science ,the Medical Information Mart for Intensive Care III ,95% confidence interval ,Critical Care and Intensive Care Medicine ,computer.software_genre ,Clinical Science Aspects ,AUPRC ,DBP ,Machine Learning ,Time windows ,HR ,heart rate ,Interpretability ,electronic medical record ,RESP ,prediction window ,AUROC ,LOS ,TEMP ,EMR ,IQR ,area under the receiver operating characteristic curve ,blood pressure ,Middle Aged ,base excess ,PaCO2 ,partial pressure of carbon dioxide ,shock index ,95% CI ,Shapley additive explanation ,Hct ,area under the precision-recall curve ,SHAP ,platelets ,Emergency Medicine ,Female ,Algorithms ,PLAGH-ERD ,partial pressure of oxygen ,Adult ,TCO2 ,interquartile range ,hematocrit ,mean blood pressure ,total carbon dioxide ,BE ,the PLA General Hospital Emergency Rescue Database ,PLT ,WBC ,Shock, Hemorrhagic ,Machine learning ,traumatic hemorrhagic shock ,BP ,THS ,length of stay ,MBP ,Humans ,respiration rate ,SI ,SBP ,Aged ,Lac ,lactate ,Vital Signs ,business.industry ,Hb ,diastolic blood pressure ,temperature ,PaO2 ,hemoglobin ,Logistic Models ,Hemorrhagic shock ,Artificial intelligence ,time series ,MIMIC III ,Blood Gas Analysis ,business ,computer ,white blood cell count - Abstract
Early warning prediction of traumatic hemorrhagic shock (THS) can greatly reduce patient mortality and morbidity. We aimed to develop and validate models with different stepped feature sets to predict THS in advance. From the PLA General Hospital Emergency Rescue Database and Medical Information Mart for Intensive Care III, we identified 604 and 1,614 patients, respectively. Two popular machine learning algorithms (i.e., extreme gradient boosting [XGBoost] and logistic regression) were applied. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the performance of the models. By analyzing the feature importance based on XGBoost, we found that features in vital signs (VS), routine blood (RB), and blood gas analysis (BG) were the most relevant to THS (0.292, 0.249, and 0.225, respectively). Thus, the stepped relationships existing in them were revealed. Furthermore, the three stepped feature sets (i.e., VS, VS + RB, and VS + RB + sBG) were passed to the two machine learning algorithms to predict THS in the subsequent T hours (where T = 3, 2, 1, or 0.5), respectively. Results showed that the XGBoost model performance was significantly better than the logistic regression. The model using vital signs alone achieved good performance at the half-hour time window (AUROC = 0.935), and the performance was increased when laboratory results were added, especially when the time window was 1 h (AUROC = 0.950 and 0.968, respectively). These good-performing interpretable models demonstrated acceptable generalization ability in external validation, which could flexibly and rollingly predict THS T hours (where T = 0.5, 1) prior to clinical recognition. A prospective study is necessary to determine the clinical utility of the proposed THS prediction models.
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- 2021
208. Catalytic [3+3] Annulation of <scp>β‐Ketoethers</scp> and Cyclopropenones via C(sp 3 )—O/C—C Bond Cleavage under <scp>Transition‐Metal</scp> Free Conditions
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Junbiao Chang, Dachang Bai, Xueyan Li, Bingbing Zheng, and Junyan Chen
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Annulation ,Transition metal ,Chemistry ,General Chemistry ,Medicinal chemistry ,Bond cleavage ,Catalysis - Published
- 2021
209. Parental Stress and Home Activities for Young Children during the Stay-at-home Quarantine Time in China
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Chenyi Zhang, Wei Qiu, Hongli Li, Liying Zhang, Xueyan Li, Jia Li, and Juan Li
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law ,Environmental health ,Quarantine ,Pandemic ,Multilevel model ,Developmental and Educational Psychology ,Parental stress ,Psychology ,Research findings ,China ,Education ,law.invention - Abstract
Research Findings: Hierarchical regression analyses were conducted to examine the associations among the family pandemic experience, home activities during the stay-at-home quarantine, and level of...
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- 2021
210. Comparison of cecal microbiota composition in hybrid pigs from two separate three-way crosses
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Jinming Ran, Huang Ying, Xueyan Li, Zhenhui Cao, Chunlian Song, Liyan Shen, Yuting Yang, Hengxin Jiang, Huan Gao, Xian Li, Zhao Sumei, and Hongbin Pan
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0301 basic medicine ,Physiology ,030106 microbiology ,Gut flora ,Article ,duroc pig ,03 medical and health sciences ,Clostridium ,Animal science ,Genetics ,Prevotella ,Eubacterium ,cecal microbiota ,16s rrna sequencing ,General Veterinary ,biology ,berkshire pig ,three-way cross model ,biology.organism_classification ,16S ribosomal RNA ,Parabacteroides ,Animal Biotechnology ,saba pig ,030104 developmental biology ,QL1-991 ,Animal Science and Zoology ,Roseburia ,Bacteroides ,Zoology ,Food Science - Abstract
Objective: The intestinal microbiota plays an important role in host physiology, metabolism, immunity, and behavior. And host genetics could influence the gut microbiota of hybrid animals. The three-way cross model is commonly utilized in commercial pig production; however, the use of this model to analyse the gut microbial composition is rarely reported. Methods: Two three-way hybrid pigs were selected, with Saba pigs as the starting maternal pig: Duroc× (Berkshire×Saba) (DBS) pig, Berkshire×(Duroc×Saba) (BDS) pig. One hundred pigs of each model were reared from 35 days (d) to 210 d. The body weight or feed consumption of all pigs were recorded and their feed/gain (F/G) ratio was calculated. On day 210, 10 pigs from each three-way cross were selected for slaughter, and cecal chyme samples were collected for 16S rRNA gene sequencing. Results: The final body weight (FBW) and average daily gain (ADG) of DBS pigs were significantly higher than those of BDS pigs (p0.05). At the genus level, the abundance of Prevotella, Roseburia, and Anaerovibrio in DBS pigs was significantly lower than in BDS pigs (pabundance of Eubacterium, Clostridium XI, Bacteroides, Methanomassiliicoccus, and Parabacteroides in DBS pigs was significantly higher than in BDS pigs (pBacteroides, ClostridiumXI, and Parabacteroides but negatively correlated with the Prevotella, Prevotella/Bacteroides (P/B) ratio, Roseburia, and Anaerovibrio. Conclusion: These results indicated that host genetics affect the cecal microbiota composition and the porcine gut microbiota is associated with growth performance, thereby suggesting that gut microbiota composition may be a useful biomarker in porcine genetics and breeding.
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- 2021
211. Three-Dimensional Reconstruction of Single Input Image Based on Point Cloud
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Yu Hou, Ruifeng Zhai, Xueyan Li, Junfeng Song, Xuehan Ma, Shuzhao Hou, and Shuxu Guo
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Computers in Earth Sciences - Abstract
Three-dimensional reconstruction from a single image has excellent future prospects. The use of neural networks for three-dimensional reconstruction has achieved remarkable results. Most of the current point-cloud-based three-dimensional reconstruction networks are trained using nonreal data sets and do not have good generalizability. Based on the Karlsruhe Institute of Technology and Toyota Technological Institute at Chicago ()data set of large-scale scenes, this article proposes a method for processing real data sets. The data set produced in this work can better train our network model and realize point cloud reconstruction based on a single picture of the real world. Finally, the constructed point cloud data correspond well to the corresponding three-dimensional shapes, and to a certain extent, the disadvantage of the uneven distribution of the point cloud data obtained by light detection and ranging scanning is overcome using the proposed method.
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- 2021
212. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
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Wei Sun, Zhi Cheng, Jiuyu Wang, Jing Yang, Xueyan Li, Jinlong Wang, Minxuan Chen, Xiaoqi Yang, Gang Sheng, Jizhong Lou, and Yanli Wang
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MOBILE genetic elements ,CRISPRS ,DNA denaturation ,MOBILE commerce - Abstract
Anti-CRISPR (Acr) proteins are encoded by phages and other mobile genetic elements and inhibit host CRISPR-Cas immunity using versatile strategies. AcrIIC4 is a broad-spectrum Acr that inhibits the type II-C CRISPR-Cas9 system in several species by an unknown mechanism. Here, we determined a series of structures of Haemophilus parainfluenzae Cas9 (HpaCas9)-sgRNA in complex with AcrIIC4 and/or target DNA, as well as the crystal structure of AcrIIC4 alone. We found that AcrIIC4 resides in the crevice between the REC1 and REC2 domains of HpaCas9, where its extensive interactions restrict the mobility of the REC2 domain and prevent the unwinding of target double-stranded (ds) DNA at the PAM-distal end. Therefore, the full-length guide RNA:target DNA heteroduplex fails to form in the presence of AcrIIC4, preventing Cas9 nuclease activation. Altogether, our structural and biochemical studies illuminate a unique Acr mechanism that allows DNA binding to the Cas9 effector complex but blocks its cleavage by preventing R-loop formation, a key step supporting DNA cleavage by Cas9. [ABSTRACT FROM AUTHOR]
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- 2023
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213. The Study on the Re-constructing Poor Spots in Beijing.
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Xiaojun Zhang, Xueyan Li, Weihong Yin, Yuansuo Zhang, Suocheng Dong, and Jinrui Wang
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- 2006
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214. Effect of SOCS3 on vocal fold fibroblast activation by regulating the JAK2/STAT3 signalling pathway
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Xueyan Li, Rong Hu, Haizhou Wang, and Wen Xu
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Transforming Growth Factor beta ,Cell Biology ,General Medicine ,Vocal Cords ,Tyrphostins ,Fibroblasts ,Developmental Biology - Abstract
To explore the regulation of SOCS3 in the JAK2/STAT3 pathway during vocal fold fibroblast activation after vocal fold injury.Normal vocal fold fibroblasts (VFFs), injured VFFs, and simulated injured VFFs (normal VFFs supplemented with transforming growth factor beta [TGF-β]) were treated with a JAK2 inhibitor (AG490), and SOCS3 was overexpressed in each group. Type I collagen (COL1), α-smooth muscle actin (α-SMA), SOCS3, JAK2, and STAT3 were detected using immunofluorescence, quantitative real-time polymerase chain reaction (qRT-PCR), and western blotting.Compared with normal VFFs, expression of SOCS3 was lower, but p-JAK/p-STAT3 and JAK2/STAT3 were higher in injured and simulated injured VFFs. After the addition of AG490, COL1 and α-SMA expressions did not change significantly in normal VFFs but was significantly decreased in the other two groups. The protein and mRNA expression levels of SOCS3 were significantly increased, while those of p-JAK/p-STAT3 and JAK2/STAT3 were significantly decreased. When SOCS3 was overexpressed, the COL1 and α-SMA expression levels in normal VFFs were not altered significantly, whereas they were significantly decreased in injured and simulated injured VFFs. The expression of p-JAK2/p-STAT3 significantly decreased when SOCS3 was overexpressed in injured and simulated injured VFFs.SOCS3 may regulate the activation of JAK2/STATA3 pathway after vocal fold injury. In addition, SOCS3 may inhibit excessive activation of vocal fold fibroblasts by downregulating JAK2/STAT3 in the early stages of vocal fold injury.
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- 2022
215. Tannic acid-crosslinked
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Xueyan, Li, Shibin, Sun, Xiaofan, Feng, Yuxin, Chen, Shaojuan, Chen, Jianwei, Ma, and Fang, Zhou
- Abstract
Bacterial infection and massive blood loss are major challenges for global public health. Herein, a series of tannic acid encapsulated
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- 2022
216. Complete mitochondrial genome of Pectocera sp. (Elateridae: Dendrometrinae: Oxynopterini) and its phylogenetic implications
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Jinwu He, Yuhao Yao, Zhiwei Dong, Yongying Ruan, Zhou Chang, Ruoping Zhao, Wen Wang, and Xueyan Li
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Coleoptera ,RNA, Transfer ,Physiology ,Insect Science ,Genome, Mitochondrial ,Animals ,General Medicine ,Biochemistry ,Phylogeny - Abstract
The Elateridae family (click beetles) represents a highly diverse lineage that possesses a specialized clicking mechanism to startle predators. At present, however, phylogenetic relationships, especially among recognized subfamilies, remain contentious. Mitochondrial genomes (mitogenomes) can help resolve previously intractable phylogenetic relationships using morphological or limited molecular data. Here, we report the complete mitogenome of Pectocera sp. (Elateridae: Dendrometrinae: Oxynopterini), which was 15,962 bp in length and showed a typical gene number and order as most beetle mitogenomes, including 13 protein-coding genes (PCGs), 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 noncoding control region (AT-rich region). Comparative genomic analyses showed a high degree of feature similarity among Pectocera sp. and other click beetles. Evolutionary analysis of all PCGs based on the nonsynonymous/synonymous substitution rate ratio (ω) indicated that cox1 and atp8 exhibited the lowest and highest evolutionary rates, respectively, and that the evolutionary rates of all PCGs, except for cox3, nad2, and nad3, were lower than the average ω of click beetles. Phylogenetic analyses based on concatenated and coalescent approaches indicated that Pectocera sp. was sister to Campsosternus auratus in the same tribe (Oxynopterini) with high support. This study offers insight into the mitogenomic basis of Pectocera sp. and provides an important data resource for exploring the taxonomy, phylogeny, and evolution of click beetles.
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- 2022
217. Characterization and expression analysis of bHLH transcription factors reveal their putative regulatory effects on nectar spur development in Aquilegia species
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Xueyan Li, Hui Huang, and Zhi-Qiang Zhang
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Genetics ,General Medicine - Abstract
Nectar spur is a hollow extension of certain flower parts and shows strikingly diverse size and shape in Aquilegia. Nectar spur development is involved in cell division and expansion processes. The basic helix-loop-helix (bHLH) transcription factors (TFs) control a diversity of organ morphogenesis, including cell division and cell expansion processes. However, the role of bHLH genes in nectar spur development in Aquilegia is mainly unknown. We conducted a genome-wide identification of the bHLH gene family in Aquilegia to determine structural characteristics and phylogenetic relationships, and to analyze expression profiles of these genes during the development of nectar spur in spurless and spurred species. A total of 120 AqbHLH genes were identified from the Aquilegia coerulea genome. The phylogenetic tree showed that AqbHLH proteins were divided into 15 subfamilies, among which S7 and S8 subfamilies occurred marked expansion. The AqbHLH genes in the same clade had similar motif composition and gene structure characteristics. Conserved residue analysis indicated nineteen residues with conservation of more than 50% were found in the four conserved regions. In the upstream sequence of AqbHLH genes, the light-responsive element was the most abundant cis-acting element. Eighteen AqbHLH genes showed syntenic relationships, and eight genes from four syntenic pairs underwent tandem duplications. According to the expression profiling analysis by public RNA-Seq data and qRT-PCR results, five AqbHLH genes, including AqbHLH027, AqbHLH046, AqbHLH082, AqbHLH083 and AqbHLH092, were differentially expressed between different tissues in A. coerulea at early developmental stages, as well as between spurless and spurred Aquilegia species. Of them, AqbHLH046 was not only highly expressed in spur compared with blade, but also showed higher expression levels in spurred species than spurless specie, suggesting it plays an essential role in the development of spur by regulating cell division. This study lays a foundation to investigate the function of AqbHLH genes family in nectar spur development, and has potential implications for speciation and genetic breeding in the genus Aquilegia.
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- 2022
218. Insight into UV-LED/PS/Fe(Ⅲ) and UV-LED/PMS/Fe(Ⅲ) for p-arsanilic acid degradation and simultaneous arsenate immobilization
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Anhong Cai, Xiao Ling, Lei Wang, Qian Sun, Shiqing Zhou, Wenhai Chu, Xueyan Li, and Jing Deng
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Environmental Engineering ,Ecological Modeling ,Oxidants ,Pollution ,Ferric Compounds ,Arsenic ,Peroxides ,Arsanilic Acid ,Animals ,Arsenates ,Waste Management and Disposal ,Oxidation-Reduction ,Water Pollutants, Chemical ,Water Science and Technology ,Civil and Structural Engineering - Abstract
As a feed additive, p-arsanilic acid (p-ASA) is hardly metabolized in animal bodies and is excreted chemically unchanged via feces and urine, which can be transformed into more toxic inorganic arsenic species and other organic by-products upon degradation in the aquatic environment. In this study, UV-LED/persulfate (PS)/Fe(Ⅲ) and UV-LED/peroxymonosulfate (PMS)/Fe(Ⅲ) processes were developed to remove p-ASA and immobilize the formed inorganic arsenic via tuning solution pH. UV-LED/PMS/Fe(Ⅲ) (90.8%) presented the best performance for p-ASA degradation at pH 3.0, and the p-ASA degradation in these processes both followed the pseudo-first-order kinetics. The ∙OH played the major role in UV-LED/PS/Fe(Ⅲ) and UV-LED/PMS/Fe(Ⅲ) systems. Solution pH greatly affected the p-ASA degradation and the maximum removal can be achieved at pH 3.0 due to the presence of more Fe(OH)(H
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- 2022
219. Degradation of tetracycline by UV/Fe
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Hanxuan, Zeng, Shuwen, Shen, Anhong, Cai, Qian, Sun, Lei, Wang, Shijun, Zhu, Xueyan, Li, and Jing, Deng
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Sulfates ,Ultraviolet Rays ,Drinking Water ,Iron ,Tetracycline ,DNA, Ribosomal ,Anti-Bacterial Agents ,Water Purification ,Kinetics ,Superoxides ,Reactive Oxygen Species ,Oxidation-Reduction ,Humic Substances ,Water Pollutants, Chemical - Abstract
As a widely produced and used antibiotic, tetracycline (TC) has been frequently found in rivers, soil and drinking water. In this study, the degradation of TC was investigated by UV/Fe
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- 2022
220. Genome‐wide identification, phylogeny and transcriptional profiling of SNARE genes in Cytospora chrysosperma
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Xueyan Li, Chengming Tian, and Dianguang Xiong
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biology ,Physiology ,Phylogenetics ,Cytospora ,Genetics ,Profiling (information science) ,Identification (biology) ,Plant Science ,Computational biology ,biology.organism_classification ,Agronomy and Crop Science ,Gene ,Genome - Published
- 2021
221. Optimal consumption and portfolios with the hyperbolic absolute risk aversion preference under the CEV model
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Xueyan Li, Hao Chang, and Xingjiang Chen
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Statistics and Probability ,Consumption (economics) ,021103 operations research ,0211 other engineering and technologies ,Elasticity (data store) ,02 engineering and technology ,Variance (accounting) ,01 natural sciences ,Hyperbolic absolute risk aversion ,010104 statistics & probability ,Constant elasticity of variance model ,Econometrics ,0101 mathematics ,Constant (mathematics) ,Preference (economics) ,Expected utility hypothesis ,Mathematics - Abstract
This paper studies the optimal investment-consumption decision under the constant elasticity of variance (CEV) model for an individual seeking to maximize the expected utility from cumulative consu...
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- 2021
222. A strategy for preparing efficient Ag/p-BNNS nanocatalyst with a synergistic effect between Ag and p-BNNS
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Qiong Lu, Jing An, Wang Desong, Qingzhi Luo, Yandong Duan, Xueyan Li, Rong Yin, and Chengchun Tang
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010405 organic chemistry ,Catalyst support ,Thermal decomposition ,Dangling bond ,chemistry.chemical_element ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Hydrogen storage ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Chemical bond ,Boron nitride ,Physical and Theoretical Chemistry ,Boron - Abstract
Porous hexagonal boron nitride nanosheets (p-BNNS) have demonstrated advantages in hydrogen storage, water purification and catalyst support. Boron nitride (BN) is generally considered chemically inert, but functionalized h-BN by physical or chemical methods breed new properties and applications and can catalyze some reactions. Herein, we developed a strategy to prepare a Ag/p-BNNS nanocatalyst via in-situ thermal decomposition of AgNO 3 at 400 °C in air (Ag/p-BNNS-Air). Results suggested that Ag nanoparticles (NPs) with a diameter of ca. 2.41 nm can be evenly anchored and dispersed on the p-BNNS and the new B O Ag chemical bonds were formed between Ag NPs and the boron dangling bonds at the edges of p-BNNS. Ag/p-BNNS-Air exhibits 20–55 fold for catalytic performance enhancement compared with that of p-BNNS-Air and Ag/p-BNNS-N2, which is attributed to the small-sized, uniformly dispersed Ag NPs and the synergistic effect between Ag and the B O bonds of p-BNNS. Our results provide a new approach for the rational design and development of metal composites and open the way to a range of important applications of p-BNNS-based materials.
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- 2021
223. Nanoscale covalent organic frameworks for enhanced photocatalytic hydrogen production
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Wei Zhao, Liang Luo, Muyu Cong, Xueyan Liu, Zhiyun Zhang, Mounib Bahri, Boyu Li, Jing Yang, Miaojie Yu, Lunjie Liu, Yu Xia, Nigel D. Browning, Wei-Hong Zhu, Weiwei Zhang, and Andrew I. Cooper
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Science - Abstract
Abstract Nanosizing confers unique functions in materials such as graphene and quantum dots. Here, we present two nanoscale-covalent organic frameworks (nano-COFs) that exhibit exceptionally high activity for photocatalytic hydrogen production that results from their size and morphology. Compared to bulk analogues, the downsizing of COFs crystals using surfactants provides greatly improved water dispersibility and light-harvesting properties. One of these nano-COFs shows a hydrogen evolution rate of 392.0 mmol g−1 h−1 (33.3 μmol h−1), which is one of the highest mass-normalized rates reported for a COF or any other organic photocatalysts. A reverse concentration-dependent photocatalytic phenomenon is observed, whereby a higher photocatalytic activity is found at a lower catalyst concentration. These materials also show a molecule-like excitonic nature, as studied by photoluminescence and transient absorption spectroscopy, which is again a function of their nanoscale dimensions. This charts a new path to highly efficient organic photocatalysts for solar fuel production.
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- 2024
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224. Cost‑effectiveness analysis of tislelizumab plus chemotherapy in Chinese patients with advanced or metastatic oesophageal squamous cell carcinoma
- Author
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Li Zhang, Henghai Su, Xueyan Liang, Xiaoyu Chen, and Yan Li
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Cost-effectiveness analysis ,Tislelizumab ,Oesophageal squamous cell carcinoma ,RATIONALE-306 ,Chemotherapy ,Medicine ,Science - Abstract
Abstract The RATIONALE-306 study revealed that patients with advanced or metastatic oesophageal squamous cell carcinoma (OSCC) could benefit from treatment with tislelizumab plus chemotherapy. This study aimed to evaluate the cost-effectiveness of tislelizumab plus chemotherapy for treating OSCC from the perspective of the Chinese healthcare system. Partitioned survival model estimated the cost-effectiveness of tislelizumab plus chemotherapy compared with chemotherapy alone for treating OSCC using RATIONALE-306 data. Costs and utilities were obtained from local databases and published studies. Costs, quality-adjusted life-years (QALYs), life-years, incremental cost-effectiveness ratios (ICER), incremental net health benefits (INHB), and incremental net monetary benefits (INMB) were outcomes. Price simulation were conducted at the willingness-to-pay (WTP) threshold. Sensitivity and subgroup analyses were performed to assess model robustness. Compared with chemotherapy alone, tislelizumab plus chemotherapy yielded an ICER of USD 27,896/QALY, gained an additional 0.414 QALYs and 0.751 life-years, and increased the cost by USD 11,560. Probabilistic sensitivity analysis revealed that tislelizumab plus chemotherapy was cost-effective at the WTP of USD 38,258/QALY with probability of 94.43%. When the price in China was less than USD 3.714 per mg, the price simulation results indicated that tislelizumab plus chemotherapy was cost-effective at a WTP threshold of USD 38,258. Tislelizumab plus chemotherapy yielded an INHB of 0.112 QALYs and an INMB of USD 4,279 compared with chemotherapy alone at a WTP threshold of USD 38,258. Based on the sensitivity analyses, the above results were stable. A general trend was observed for subgroups with better survival benefits related to a higher probability of cost-effectiveness. From the Chinese healthcare perspective, tislelizumab plus chemotherapy is more cost-effective than chemotherapy alone as a first-line therapy for OSCC. These findings can help clinicians make optimal clinical decisions and assist decision-makers in evaluating the cost-effectiveness of tislelizumab in clinical practice.
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- 2024
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225. First-line serplulimab plus chemotherapy versus chemotherapy in PD-L1-positive esophageal squamous-cell carcinoma: a cost-effectiveness analysis
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Xueyan Liang, Mingyu Meng, Shiran Qin, Xiaoyu Chen, and Yan Li
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Serplulimab ,Esophageal squamous cell carcinoma ,Cost-effectiveness ,Chemotherapy ,Partitioned survival model ,Medicine ,Science - Abstract
Abstract Patients with PD-L1-positive esophageal squamous-cell carcinoma (ESCC) were significantly more likely to survive when treated with serplulimab plus cisplatin plus 5-fluorouracil (serplulimab-CF). At this point, it is unknown whether this expensive therapy is cost-effective. From the Chinese healthcare system's perspective, we aimed to evaluate serplulimab-CF versus CF alone for cost-effectiveness. A partitioned survival model was constructed based on the ASTRUM-007 trial. Quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratio (ICER) were calculated. A further analysis of subgroups and scenarios was conducted. The willingness to pay (WTP) threshold of $38,258/QALY or $84,866/QALY is defined as three times the per capita gross domestic product value of the general region or affluent region. Compared with CF alone, in the overall (scenario 1), patients with PD-L1 expression level of 1 ≤ CPS
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- 2024
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226. Cytotoxicity, endocrine disrupting activity, and chemical analysis of 42 food contact silicone rubber products
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Di Feng, Xueyan Li, Xiaojie Fan, Yifan Guo, Jingwei Zhang, Hang Yuan, Wenjuan Wang, Tingting Zhao, and Tian Han
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Environmental Engineering ,Environmental Chemistry ,Pollution ,Waste Management and Disposal - Published
- 2023
227. Degradation of antiviral drug acyclovir by thermal activated persulfate process: Kinetics study and modeling
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Chunsheng Ding, Zhiyue Cai, Chenkai Hu, Jia Lei, Lei Wang, Qingsong Li, Xueyan Li, and Jing Deng
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Environmental Engineering ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Environmental Chemistry ,General Medicine ,General Chemistry ,Pollution - Published
- 2023
228. Three-electrode germanium-on-silicon avalanche photodiode array
- Author
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XiaoBin Liu, XueTong Li, ZiHao ZHi, YingZhi Li, BaiSong Chen, QiJie Xie, Quanxin Na, XueYan Li, PengFei Guo, FengLi Gao, GuoQiang Lo, BoNan Kang, and Junfeng Song
- Subjects
Atomic and Molecular Physics, and Optics - Abstract
In this Letter, we report a bridge-connected three-electrode germanium-on-silicon (Ge-on-Si) avalanche photodiode (APD) array compatible with the complementary metal-oxide semiconductor (CMOS) process. In addition to the two electrodes on the Si substrate, a third electrode is designed for Ge. A single three-electrode APD was tested and analyzed. By applying a positive voltage on the Ge electrode, the dark current of the device can be reduced, and yet the response of the device can be increased. Under a dark current of 100 nA, as the voltage on Ge increases from 0 V to 15 V, the light responsivity is increased from 0.6 A/W to 1.17 A/W. We report, for the first time to the best of our knowledge, the near-infrared imaging properties of an array of three-electrode Ge-on-Si APDs. Experiments show that the device can be used for LiDAR imaging and low-light detection.
- Published
- 2023
229. Facile preparation of α-MnO2 nanowires for assembling free-standing membrane with efficient Fenton-like catalytic activity
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Yufei Zhen, Zhiqiang Sun, Ziye Jia, Caihong Liu, Shishu Zhu, Xueyan Li, Wei Wang, and Jun Ma
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General Chemistry - Published
- 2023
230. Genome-wide identification and gene-editing of pigment transporter genes in the swallowtail butterfly Papilio xuthus
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Xueyan Li, Wen Wang, Zhou Chang, Lei Chen, Jinwu He, Zhiwei Dong, Wei Liu, Wenting Wan, Ruoping Zhao, and Guichun Liu
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Male ,Heme binding ,Papilio xuthus ,lcsh:QH426-470 ,lcsh:Biotechnology ,Gene Expression ,ATP-binding cassette transporter ,Biology ,03 medical and health sciences ,0302 clinical medicine ,lcsh:TP248.13-248.65 ,Genetics ,Animals ,ATP-binding cassette (ABC) transporters ,Gene ,CRISPR/Cas9 ,Swallowtail butterfly ,030304 developmental biology ,0303 health sciences ,Glycoprotein binding ,Pigmentation ,Rab transporters ,biology.organism_classification ,Bombyx ,lcsh:Genetics ,Larva ,Iron ion binding ,Rab ,Transcriptome ,Butterflies ,030217 neurology & neurosurgery ,Biotechnology ,Research Article - Abstract
Background Insect body coloration often functions as camouflage to survive from predators or mate selection. Transportation of pigment precursors or related metabolites from cytoplasm to subcellular pigment granules is one of the key steps in insect pigmentation and usually executed via such transporter proteins as the ATP-binding cassette (ABC) transmembrane transporters and small G-proteins (e.g. Rab protein). However, little is known about the copy numbers of pigment transporter genes in the butterfly genomes and about the roles of pigment transporters in the development of swallowtail butterflies. Results Here, we have identified 56 ABC transporters and 58 Rab members in the genome of swallowtail butterfly Papilio xuthus. This is the first case of genome-wide gene copy number identification of ABC transporters in swallowtail butterflies and Rab family in lepidopteran insects. Aiming to investigate the contribution of the five genes which are orthologous to well-studied pigment transporters (ABCG: white, scarlet, brown and ok; Rab: lightoid) of fruit fly or silkworm during the development of swallowtail butterflies, we performed CRISPR/Cas9 gene-editing of these genes using P. xuthus as a model and sequenced the transcriptomes of their morphological mutants. Our results indicate that the disruption of each gene produced mutated phenotypes in the colors of larvae (cuticle, testis) and/or adult eyes in G0 individuals but have no effect on wing color. The transcriptomic data demonstrated that mutations induced by CRISPR/Cas9 can lead to the accumulation of abnormal transcripts and the decrease or dosage compensation of normal transcripts at gene expression level. Comparative transcriptomes revealed 606 ~ 772 differentially expressed genes (DEGs) in the mutants of four ABCG transporters and 1443 DEGs in the mutants of lightoid. GO and KEGG enrichment analysis showed that DEGs in ABCG transporter mutants enriched to the oxidoreductase activity, heme binding, iron ion binding process possibly related to the color display, and DEGs in lightoid mutants are enriched in glycoprotein binding and protein kinases. Conclusions Our data indicated these transporter proteins play an important role in body color of P. xuthus. Our study provides new insights into the function of ABC transporters and small G-proteins in the morphological development of butterflies.
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- 2021
231. Precise Demand Forecast Analysis of New Retail Target Products Based on Combination Model
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Weiwei Yao, Jinli Jiang, and Xueyan Li
- Subjects
Inventory management ,Computer science ,Order (business) ,Linear regression ,Econometrics ,Diversification (finance) ,Autoregressive integrated moving average ,Demand forecasting ,Multiple linear regression model - Abstract
In order to satisfy the consumers’ pursuit of diversification of goods, new retail enterprises begin to gradually produce small quantities and various kinds of products, which makes the sales data become more complex and various, and then makes the inventory management more difficult. Therefore, it is very necessary to establish an accurate demand prediction model for the sub-category stratum. In this paper, we firstly consider the effect of external macrofactors on sales, and establish a multiple linear regression model to forecast the sales of the target products. Then we consider the regularity and trendency of previous sales, comparing the fitting degree of different parameter ARIMA models, and finally establish the ARIMA (2, 2, 1) model with the best prediction effect. Finally, in the light of the fitting degree, the two models are given different weights, and a predictive model that combines multiple linear regression and ARIMA (2, 2, 1) is established. It can be shown from the results that the prediction effect of combined model is better and it can accurately predict needs for new retail goods, thereby reducing the difficulty of inventory management and improving corporate competitiveness.
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- 2021
232. An electrochemical method for the sensitive and rapid sensing of Sudan I in food based on Ni–Fe bimetal organic frameworks
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Xiuxiu Sun, Maoguo Li, Xueyan Li, Ani Zhou, and Zichun Zhu
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Detection limit ,Sudan I ,medicine.diagnostic_test ,Scanning electron microscope ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Bimetal ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Spectrophotometry ,Electrode ,Materials Chemistry ,medicine ,Differential pulse voltammetry ,0210 nano-technology ,Bimetallic strip - Abstract
Traditional metal–organic frameworks (MOFs), although have the ability to accumulate some chemicals from solution, are usually electrochemically inert. Here, spherical MIL-53(NiFe) MOFs have been synthesized via a simple solvothermal method. A series of characterization methods including scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectrophotometry, energy dispersive X-ray spectroscopy (EDS), and element mapping were used to investigate this material. An MIL-53(NiFe)/AB/GCE-modified electrode was constructed using acetylene black (AB) as the conductive substrate, which can make up for the electrochemical inertness of metal in the MOFs to some extent. Moreover, the bimetallic center can coordinate with the azo functional group in Sudan I to some extent, which is beneficial to the binding of the molecules to the electrode. Thus, the sensitive and rapid detection of Sudan I can be realized. The quantitative determination of Sudan I was carried out via the differential pulse voltammetry (DPV) method in a wider linear range (0.005–10 μM) and lower detection limit (0.002 μM, S/N = 3). The developed method can be successfully applied to the detection of Sudan I in chilli powder and tomato paste with satisfactory results.
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- 2021
233. Precision-Improved Pulsed Laser Ranging by Multidelayed Echo Signals Triggering
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Fengli Gao, Changchun Ding, Min Tao, Liangli Gao, Xueyan Li, Jian Guan, Tao Peng, Zhixin Song, and Siyao Yu
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Materials science ,Pulse (signal processing) ,business.industry ,Echo (computing) ,Ranging ,Chip ,Laser ,Signal ,law.invention ,Lidar ,Optics ,law ,Logic gate ,Electrical and Electronic Engineering ,business ,Instrumentation - Abstract
We propose a pulsed laser ranging method based on a multiecho delay trigger, which improves the precision of pulsed laser ranging. A signal delay unit is used to accurately delay the pulse-echo signal. In a fixed time window, the echo delay pulse triggers the laser transmitter to generate pulsed laser light; meanwhile, the counter records several echo pulses received, and then, the actual distance can be calculated. In terms of improving the ranging precision, this method overcomes the essential of higher time resolution time-to-digital converter (TDC) chip in traditional time-of-flight (TOF) pulsed laser ranging. The method can be realized by using a field-programmable logic gate array (FPGA) chip, a delay unit, and a set of laser transmitters and receivers, which makes the system structure simple and low cost. Experimental results show that this method can achieve more accurate distance measurement and significantly reduced error, to the best of our knowledge, which improves the pulsed laser ranging from centimeter- to millimeter-order precisions. We believe that this method has a promising application prospect in the field of high-precision pulsed laser ranging of fixed targets.
- Published
- 2021
234. Research on Precision Teaching in Higher Education Classrooms in the Context of Big Data
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Xueyan Li
- Published
- 2021
235. Comprehensive Evaluation of Tourism Development Potential in Anhui Province Based on Cluster Analysis and Factor Analysis
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Xueyan Li, Xiaoxiao Zhan, and Jinli Jiang
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Geography ,Index system ,Ranking ,Regional science ,Disease cluster ,Tourism ,Urban tourism - Abstract
In order to improve the potential of urban tourism in Anhui Province, the comprehensive evaluation of the development level of urban tourism in Anhui Province is carried out. Firstly, the comprehensive evaluation index system of the development level of tourism is constructed. Secondly, 16 cities in Anhui Province are divided into four categories through cluster analysis, and Hefei has the best tourism development. Then factor analysis is carried out to get the ranking of each prefecture-level city. The top two cities in tourism development level are Hefei and Huangshan. Finally, the conclusion is that the tourism development level of 16 cities in Anhui Province is not balanced and the tourism industry is still to be developed.
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- 2021
236. Chromatin accessibility profiling provides insights into larval cuticle color and adult longevity in butterflies
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Chu-Yang Mao, Zhiwei Dong, Wenting Wan, Xueyan Li, Xiang-Yu Pan, Guichun Liu, Jinwu He, Wei Liu, Hu Ping, Yandong Ren, Wen Wang, Zhou Chang, Ruoping Zhao, Jun Li, and Jie Yang
- Subjects
Melanogenesis ,Papilio xuthus ,media_common.quotation_subject ,Ontogeny ,Longevity ,ATAC-seq ,Biology ,Kallima inachus ,Animals ,Letter to the Editor ,Gene ,Ecology, Evolution, Behavior and Systematics ,media_common ,Ecology ,Pigmentation ,Gene Expression Regulation, Developmental ,Pigments, Biological ,Phenotypic trait ,biology.organism_classification ,Chromatin ,Pupa ,QL1-991 ,Evolutionary biology ,Larva ,Animal Science and Zoology ,Integumentary System ,Transcriptome ,Zoology ,Butterflies - Abstract
Butterflies are diverse in virtually all aspects of their ontogeny, including morphology, life history, and behavior. However, the developmental regulatory mechanisms underlying the important phenotypic traits of butterflies at different developmental stages remain unknown. Here, we investigated the developmental regulatory profiles of butterflies based on transposase accessible chromatin sequencing (ATAC-seq) at three developmental stages in two representative species ( Papilio xuthus and Kallima inachus). Results indicated that 15%-47% of open chromatin peaks appeared in associated genes located 3 kb upstream (i.e., promoter region) of their transcription start site (TSS). Comparative analysis of the different developmental stages indicated that chromatin accessibility is a dynamic process and associated genes with differentially accessible (DA) peaks show functions corresponding to their phenotypic traits. Interestingly, the black color pattern in P. xuthus 4th instar larvae may be attributed to promoter peak-related genes involved in the melanogenesis pathway. Furthermore, many longevity genes in 5th instar larvae and pupae showed open peaks 3 kb upstream of their TSS, which may contribute to the overwintering diapause observed in K. inachus adults. Combined with RNA-seq analysis, our data demonstrated that several genes enriched in the melanogenesis and longevity pathways also exhibit higher expression, confirming that the expression of genes may be closely related to their phenotypic traits. This study offers new insights into larval cuticle color and adult longevity in butterflies and provides a resource for investigating the developmental regulatory mechanisms underlying butterfly ontogeny.
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- 2021
237. Author response: Admixture of evolutionary rates across a butterfly hybrid zone
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Tianzhu Xiong, Xueyan Li, Masaya Yago, and James Mallet
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- 2022
238. Value of CT Radiomics and Clinical Features in Predicting Bone Metastases in Patients with NSCLC
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Lu Chen, Lijuan Yu, Xueyan Li, Zhanyu Tian, and Xiuyan Lin
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Keratin-19 ,Lung Neoplasms ,Article Subject ,Antigens, Neoplasm ,Predictive Value of Tests ,Carcinoma, Non-Small-Cell Lung ,Humans ,Radiology, Nuclear Medicine and imaging ,Bone Neoplasms ,Tomography, X-Ray Computed ,Retrospective Studies - Abstract
Objective. To explore the CT radiomic features and clinical imaging features of the primary tumor in patients with nonsmall cell lung cancer (NSCLC) before treatment and their predictive value for the occurrence of bone metastases. Methods. From June 2017 to June 2021, 195 patients with NSCLC who were pathologically diagnosed without any treatment in the Cancer Hospital Affiliated to Hainan Medical College were retrospectively analyzed, and they were divided into a bone metastasis group and a nonbone metastasis group. The relationship between clinical imaging features and bone metastasis in patients was analyzed by the t-test, rank sum test, and χ2 test. At the same time, ITK software was used to extract the radiomic characteristics of the primary tumor of the patients, and the patients were randomly divided into a training group and a validation group in a ratio of 7 : 3. The training model was validated in the validation group, and the performance of the model for predicting bone metastases in NSCLC patients was verified by the ROC curve, and a multivariate logistic regression prediction model was established based on the omics parameters extracted from the best prediction model combined with clinical image features. Results. Seven features were screened from the primary tumor by LASSO to establish a model for predicting metastasis. The area under the curve was 0.82 and 0.73 in the training and validation sets. The best omics signature and univariate analysis suggested clinical imaging factors P < 0.05 associated with bone metastases were included in multivariate binary logistic analysis to obtain clinical characteristics of the primary tumor such as gender (OR = 0.141, 95% CI: 0.022–0.919, P = 0.04), increased Cyfra21-1 (OR = 0.12, 95% CI: 0.018–0.782, P = 0.027), Fe content in blood (OR = 0.774, 95% CI: 0.626–0.958, P = 0.018), CT signs such as lesion homogeneity (OR = 0.052, 95% CI: 0.006–0.419, P = 0.006), pleural indentation sign (OR = 0.007, 95% CI: 0.001–0.696, P = 0.034), and omics characteristics glszm_Small Area High Gray Level Emphasis (OR = 0.016, 95% CI: 0.001–0.286, P = 0.005) were independent risk factors for bone metastasis in patients. Conclusion. The prediction model established based on radiomics and clinical imaging features has high predictive performance for the occurrence of bone metastasis in NSCLC patients.
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- 2022
239. A comparison of oxidation and re-flocculation behaviors of Fe
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Xiao, Ling, Anhong, Cai, Minjie, Chen, Honglei, Sun, Shanlin, Xu, Zhiyuan, Huang, Xueyan, Li, and Jing, Deng
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Sewage ,Flocculation ,Water ,Hydrogen Peroxide ,Reactive Oxygen Species ,Oxidation-Reduction ,Waste Disposal, Fluid - Abstract
In this study, Fe
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- 2022
240. Learning-based landmark detection in pelvis x-rays with attention mechanism: data from the osteoarthritis initiative
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Yun Pei, Lin Mu, Chuanxin Xu, Qiang Li, Gan Sen, Bin Sun, Xiuying Li, and Xueyan Li
- Subjects
Radiography ,X-Rays ,Osteoarthritis ,Humans ,Tomography, X-Ray Computed ,General Nursing ,Pelvis - Abstract
Patients with developmental dysplasia of the hip can have this problem throughout their lifetime. The problem is difficult to detect by radiologists throughout x-ray because of an abrasion of anatomical structures. Thus, the landmarks should be automatically and precisely located. In this paper, we propose an attention mechanism of combining multi-dimension information on the basis of separating spatial dimension. The proposed attention mechanism decouples spatial dimension and forms width-channel dimension and height-channel dimension by 1D pooling operations in the height and width of spatial dimension. Then non-local means operations are performed to capture the correlation between long-range pixels in width-channel dimension, as well as that in height-channel dimension at different resolutions. The proposed attention mechanism modules are inserted into the skipped connections of U-Net to form a novel landmark detection structure. This landmark detection method was trained and evaluated through five-fold cross-validation on an open-source dataset, including 524 pelvis x-ray, each containing eight landmarks in pelvis, and achieved excellent performance compared to other landmark detection models. The average point-to-point errors of U-Net, HR-Net, CE-Net, and the proposed network were 3.5651 mm, 3.6118 mm, 3.3914 mm and 3.1350 mm, respectively. The results indicate that the proposed method has the highest detection accuracy. Furthermore, an open-source pelvis dataset is annotated and released for open research.
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- 2022
241. Comparison of UV and UV-LED activated sodium percarbonate for the degradation of O-desmethylvenlafaxine
- Author
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Jing Deng, Anhong Cai, Xiao Ling, Qian Sun, Tianxin Zhu, Qingsong Li, Xueyan Li, and Weizhu Chen
- Subjects
Environmental Engineering ,Photolysis ,Phenols ,Desvenlafaxine Succinate ,Venlafaxine Hydrochloride ,Environmental Chemistry ,Humans ,General Medicine ,General Environmental Science - Abstract
As an active metabolite of venlafaxine and emerging antidepressant, O-desmethylvenlafaxine (ODVEN) was widely detected in different water bodies, which caused potential harm to human health and environmental safety. In this study, the comparative work on the ODVEN degradation by UV (254 nm) and UV-LED (275 nm) activated sodium percarbonate (SPC) systems was systematically performed. The higher removal rate of ODVEN can be achieved under UV-LED direct photolysis (14.99%) than UV direct photolysis (4.57%) due to the higher values of photolysis coefficient at the wavelength 275 nm. Significant synergistic effects were observed in the UV/SPC (80.38%) and UV-LED/SPC (53.57%) systems and the former exhibited better performance for the elimination of ODVEN. The degradation of ODVEN all followed the pseudo-first-order kinetics well in these processes, and the pseudo-first-order rate constant (k
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- 2022
242. Genome-wide identification and expression analysis of bHLH transcription factors reveal their putative regulatory effects on petal nectar spur development in Aquilegia
- Author
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Xueyan Li, Hui Huang, and Zhi-Qiang Zhang
- Abstract
The basic helix-loop-helix (bHLH) transcription factors (TFs) control a diversity of organ morphogenesis involved in cell division and cell expansion processes. The development of petal nectar spur, which plays important roles in plant-pollinator interaction and adaptive radiation, comprised cell division and cell expansion phases in Aquilegia. Here, we conducted a genome-wide identification of the bHLH gene family in Aquilegia to determine the characteristics and the expression profiles of this gene family during the development of petal nectar spur. A total of 120 AqbHLH proteins were identified from the Aquilegia coerulea genome. The phylogenetic tree showed that AqbHLH members were divided into 15 subfamilies, among which S7 and S8 subfamilies occurred marked expansion. Nineteen residues with conservation of more than 50% were found in the four conserved regions. The publicly RNA-Seq data and qRT-PCR results showed that AqbHLH027, AqbHLH083, AqbHLH046, and AqbHLH092 would be associated with the development of petal nectar spur by regulating cell division and cell cycle in phase I. While AqbHLH036 might participate the spur cell elongation and cell expansion in phase Ⅱ. This study provides useful insights for further probing on the function of AqbHLH TFs in the regulation of petal nectar spur development.
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- 2022
243. Comprehensive Evaluation of Lithium-ion Battery Recycling Station Based on Pythagorean Intuitionistic Fuzzy Analysis Modified Expression Difference
- Author
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Zhongwei Cheng, Shaotong Wu, Lifeng Yang, Xueyan Li, and Feiyu Chen
- Abstract
With the popularity of lithium-ion battery (LIB) vehicles, End of Life-lithium-ion batteries (EoL-LIB) pollute the environment, but their recycling has great economic value. Therefore, service efficiency and location of EoL-LIB recycling station (ELRS) have become a concern. Aiming at the comprehensive evaluation of the service efficiency of ELRSs, this study constructed an evaluation index system of the service efficiency of ELRSs, including 5 first-level indicators, such as incentive factors of system sound, economic benefit, social effect, technological innovation and management innovation. In this study, the fuzzy analytic hierarchy process (FAHP), the fuzzy processing of 7-granularity language variables and the intuitionistic fuzzy weighted mean (IFWA) operator aggregate quantitative evaluation matrix were adopted. Based on the prospect theory, a weight correction model of individual expression tendency index was constructed. Secondly, we used Maximum deviation method (MDM) and Shapley fuzzy measure to build a two-stage optimization model, and then determined the optimal weight. Thirdly, according to performance function and accuracy function, we used Partition normalized weighted Bonferroni mean (PFPNWBM) operator to calculate the optimal ranking of ELRSs. Finally, an example was given to analyze the difference between the first-order linear optimization model and the two-stage optimization model, and the practical value of using Shapley function-based two-stage linear optimization model to evaluate the comprehensive service efficiency of ELRSs was verified.
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- 2022
244. Unraveling spongy Co
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Hanxuan, Zeng, Xiao, Ling, Hao, Zhu, Jing, Deng, Xiaoyan, Ma, Haojie, Zhang, Lin, Deng, Zhou, Shi, and Xueyan, Li
- Abstract
Peroxymonosulfate (PMS) activation induced by tricobalt tetroxide spinel (Co
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- 2022
245. A novel pre-magnetized ZVI/PS pretreatment for improving sludge dewaterability: The role of EPS fractions
- Author
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Xiao Ling, Minjie Chen, Anhong Cai, Honglei Sun, Shanlin Xu, Lei Wang, Xueyan Li, and Jing Deng
- Subjects
History ,Environmental Engineering ,Polymers and Plastics ,Sewage ,Iron ,Water ,General Medicine ,Management, Monitoring, Policy and Law ,Waste Disposal, Fluid ,Industrial and Manufacturing Engineering ,Business and International Management ,Waste Management and Disposal ,Oxidation-Reduction ,Filtration - Abstract
The dewaterability of waste-activated sludge (WAS) has been extensively examined using zero-valent iron (ZVI)-based advanced oxidation processes (AOPs). However, the high dosage and low utilization efficiencies of ZVI cast doubt on the dependability and viability of ZVI-based AOPs. In this study, we successfully demonstrated pre-magnetization as an efficient, chemical-free, and ecological method for improving the efficiency of sludge dewatering by ZVI/persulfate (PS) process, in which the reduction ratios of capillary suction time (CST) and specific resistance to filtration (SRF) increased by 8.67% and 11.06% under optimal conditions, respectively. The highly active Fe
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- 2022
246. Dynamic origin of anomalous subsidence of Jurassic Ordos basin
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Neng Wan, Shaofeng Liu, Guangting Liu, and Xueyan Li
- Abstract
The Jurassic Ordos basin is generally considered an intracontinental basin characterized by rapid subsidence rate along western margin and slow subsidence rate within basin interior. However, the formation mechanism of Ordos basin was not yet well understood. Flexural backstripping of stratigraphic record spanning from 174-153Ma, along three well sections perpendicular to the western margin of Ordos basin clearly demonstrates that there were long wavelength anomalous subsidence components, termed residual subsidence, in addition to those induced by thrust loads and sediment loads. Flexural components exhibit similar spatial and temporal trends along three sections. Simulations demonstrates that the foredeep is only 80-100 km wide, corresponding to effective thickness of 15-20 km. Contribution by flexural component relative to cumulative subsidence decreases from 50-60% to -15% within foredeep from thrust front towards basin interior, while residual subsidence could account for 40-50% of cumulative subsidence for areas outboard extent of foredeep. From 174-153 Ma, residual subsidence increases from ~150 m to ~330 m, ~200 m to ~390 m, ~180 m to ~480 m in southern, middle and northern section respectively. Our results indicate that thrust loads could act as the dominant driver for subsidence of foredeep while other mechanism needs to be raised to explain the basin-wide anomalous residual subsidence. The general agreement regarding both magnitude and trends along all three sections between dynamic topography predicted by geodynamic models and residual subsidence separated from flexural modeling, indicates that the anomalous subsidence component might be of dynamic origin, related to subduction of paleo-Pacific plate initiated from latest Early Jurassic.
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- 2022
247. Single-trial-based temporal principal component analysis on extracting event-related potentials of interest for an individual subject
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Guanghui Zhang, Xueyan Li, Yingzhi Lu, Timo Tiihonen, Zheng Chang, and Fengyu Cong
- Subjects
back-projection ,single-trial analysis ,individual subject ,principal component analysis ,General Neuroscience ,event-related potentials - Abstract
Background: Temporal principal component analysis (tPCA) has been widely used to extract event-related potentials (ERPs) at group level of multiple subjects ERP data and it assumes that the underlying factor loading is fixed across participants. However, such assumption may fail to work if latency and phase for one ERP vary considerably across participants. Furthermore, effect of number of trials on tPCA decomposition has not been systematically examined as well, especially for within-subject PCA. New method: We reanalyzed a real ERP data of an emotional experiment using tPCA to extract N2 and P2 from single-trial EEG of an individual. We also explored influence of the number of trials (consecutively increased from 10 to 42 trials) on PCA decomposition by comparing temporal correlation, the statistical result, Cronbach’s alpha, spatial correlation of both N2 and P2 for the proposed method with the conventional time-domain analysis, trial-averaged group PCA, and single-trial-based group PCA. Results: The results of the proposed method can enhance spatial and temporal consistency. We could obtain stable N2 with few trials (about 20) for the proposed method, but, for P2, approximately 30 trials were needed for all methods. Comparison with Existing Method(s): About 30 trials for N2 were required and the reconstructed P2 and N2 were poor correlated across participants for the other three methods. Conclusion: The proposed approach may efficiently capture variability of one ERP from an individual that cannot be extracted by group PCA analysis. peerReviewed
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- 2022
248. Trends in the prevalence of osteoporosis and effects of heavy metal exposure using interpretable machine learning
- Author
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Hewei Xiao, Xueyan Liang, Huijuan Li, Xiaoyu Chen, and Yan Li
- Subjects
Machine learning ,Heavy metals ,Osteoporosis ,Blood ,Urinary ,Environmental pollution ,TD172-193.5 ,Environmental sciences ,GE1-350 - Abstract
There is limited evidence that heavy metals exposure contributes to osteoporosis. Multi-parameter scoring machine learning (ML) techniques were developed using National Health and Nutrition Examination Survey data to predict osteoporosis based on heavy metal exposure levels. For generating an optimal predictive model for osteoporosis, 12 ML models were used. Identification was carried out using the model that performed the best. For interpretation of models, Shapley additive explanation (SHAP) methods and partial dependence plots (PDP) were integrated into a pipeline and incorporated into the ML pipeline. By regressing osteoporosis on survey cycles, logistic regression was used to evaluate linear trends in osteoporosis over time. For the purpose of training and validating predictive models, 5745 eligible participants were randomly selected into training and testing set. It was evident from the results that the gradient boosting decision tree model performed the best among the predictive models, attributing to an accuracy rate of 89.40 % in the testing set. Based on the model results, the area under the curve and F1 score were 0.88 and 0.39, respectively. As a result of the SHAP analysis, urinary Co, urinary Tu, blood Cd, and urinary Hg levels were identified as the most influential factors influencing osteoporosis. Urinary Co (0.20–6.10 μg/mg creatinine), urinary Tu (0.06–1.93 μg/mg creatinine), blood Cd (0.07–0.50 μg/L), and urinary Hg (0.06–0.75 μg/mg creatinine) levels displayed a distinctive upward trend with risk of osteoporosis as values increased. Our analysis revealed that urinary Co, urinary Tu, blood Cd, and urinary Hg played a significant role in predictability.
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- 2024
- Full Text
- View/download PDF
249. Predicting the properties of bitumen using machine learning models trained with force field atom types and molecular dynamics simulations
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Eli I. Assaf, Xueyan Liu, Peng Lin, Shisong Ren, and Sandra Erkens
- Subjects
Molecular Dynamics ,Machine Learning ,Bitumen Design ,Chemical Descriptors ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
This study enhances the molecular analysis of bitumen by transitioning from traditional chemical descriptors, such as SARA (Saturates, Aromatics, Resins, and Asphaltenes) fractions and elemental compositions, to specific force field atom types in Molecular Dynamics (MD) models. This shift improves the precision in predicting material properties critical for bituminous material characterization. Machine Learning Models (MLMs) were developed to use these atom types as input features, inherently reflecting fundamental chemical characteristics. Trained on data from over 1,770 LAMMPS simulations of diverse bitumen types and conditions, these MLMs enable the prediction of properties like density, heat capacity, solubility parameters, and thermal expansion coefficients without the need for additional MD simulations. The models utilize 30 chemical descriptors corresponding to specific atom types in the PCFF force field, which collectively account for over 95% of the influence on these properties. By accurately predicting fundamental, thermodynamic, and kinetic properties, the use of MLMs and force field atom types allows researchers to efficiently tweak the chemical nature of organic molecules and mixtures to achieve desired properties. With near-instantaneous prediction times, these MLMs offer valuable insights for advancing bitumen research in the construction and petroleum industries, reducing the need for more intensive simulation techniques.
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- 2024
- Full Text
- View/download PDF
250. Evaluation of the therapeutic effects of photodynamic therapy in vulvar lichen sclerosus and impact on patient quality of life and sexual funtion
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Yanxia Cao, Zhongyu Qu, Xiangqin Sun, Guoying Cui, Hao Wei, Zhifeng Wang, and Xueyan Lin
- Subjects
Vulvar lichen sclerosus ,Photodynamic therapy ,Quality of life,sexual function ,Medicine (General) ,R5-920 - Abstract
Background: Vulvar lichen sclerosus (VLS) is often associated with irritable symptoms of itching, burning pain and can lead to scarring, architectural changes and sexual dysfunction as well as a decline in quality of life. The etiology of the disease is unknown. This study sought to assess the therapeutic effects of Photodynamic Therapy (PDT) in VLS, and improvment of patient quality of life and sexual funtion. Methods: From January 2022 to April 2023, a total of 65 patients with vulvar sclerosus (VLS) were treated with PDT in our hospital. All 65 patients were divided into two groups: early-stage group and late-stage group. The Cattaneo scoring method, the Dermatology Life Quality Index (DLQI) and the Female Sexual Function Index (FSFI) scores were used to evaluate the clinical effectiveness of the treatment on patients’ symptoms and clincal signs, quality of life as well as sexual function before and at 6-month after treatment. Results: The total effective rate of early-stage patients was significantly greater than that of late-stage patients at 6-month after PDT treatment (90.91 % [40/44] vs 76.19 % [16/21], p < 0.05). At 6-month follow-up, the symptoms and clinical signs of patients in early-stage group were significantly improved compared with baseline, the average scores of itching, skin elasticity, whitening and lesion range were significantly lower than the scores before treatment (p < 0.05). In late-stage group, The decrease in scores of itching, whitening and lesion range at the 6-months follow-up is significant(p < 0.05), but skin elasticity (p = 0.0625). On post-treatment follow-up examination, FSFI score was seen to have significantly improved in early-stage patients(from a median score of 17.45 to 21.1, p < 0.05); DLQI also significantly improved after treatment (from a median score of 7 to 4, p < 0.05). In late stage patients, The DLQI score improved significantly after treatment (from a median score of 18 to 15, p < 0.05). However, the improvement in sexual function is not statistically significant (pre-treatment: median=10.55, post-treatment: median=10, p = 0.1865). Conclusion: Photodynamic therapy can effectively improve most symptoms and clinical signs, as well as quality of life of patients with VLS, especially for earlly stage patients. Moreover, improvement in sexual function is observed in early stage patients after PDT treatment. This study suggests that early and timely PDT treatment are recommended to achieve better results.
- Published
- 2024
- Full Text
- View/download PDF
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