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1,361 results on '"Xu Jiake"'

206. Donkey genomes provide new insights into domestication and selection for coat color

Author

National Natural Science Foundation of China, Natural Science Foundation of Shandong Province, Wang, Changfa, Li, Haijing, Guo, Yu, Huang, Jinming, Sun, Yan, Min, Jiumeng, Wang, Jinpeng, Fang, Xiaodong, Zhao, Zicheng, Wang, Shuai, Zhang, Yanlin, Liu, Qingfeng, Jiang, Qiang, Wang, Xiuge, Guo, Yijun, Yang, Chunhong, Wang, Yinchao, Tian, Fang, Zhuang, Guilong, Fan, Yanna, Gao, Qican, Li, Yuhua, Ju, Zhihua, Li, Jianbin, Li, Rongling, Hou, Minghai, Yang, Guiwen, Liu, Guiqin, Liu, Wenqiang, Guo, Jiao, Pan, Shanshan, Fan, Guangyi, Zhang, Wei, Zhang, Ruitao, Yu, Jie, Zhang, Xinhao, Yin, Qi, JI, Chuanliang, Yue, Guidong, Liu, Mei, Xu, Jiake, Liu, Shimin, Jordana, Jordi, Noce, Antonia, Amills, Marcel, Wu, Dong Dong, Li, Shuaicheng, Zhou, Xiangshan, Zhong, Jifeng, National Natural Science Foundation of China, Natural Science Foundation of Shandong Province, Wang, Changfa, Li, Haijing, Guo, Yu, Huang, Jinming, Sun, Yan, Min, Jiumeng, Wang, Jinpeng, Fang, Xiaodong, Zhao, Zicheng, Wang, Shuai, Zhang, Yanlin, Liu, Qingfeng, Jiang, Qiang, Wang, Xiuge, Guo, Yijun, Yang, Chunhong, Wang, Yinchao, Tian, Fang, Zhuang, Guilong, Fan, Yanna, Gao, Qican, Li, Yuhua, Ju, Zhihua, Li, Jianbin, Li, Rongling, Hou, Minghai, Yang, Guiwen, Liu, Guiqin, Liu, Wenqiang, Guo, Jiao, Pan, Shanshan, Fan, Guangyi, Zhang, Wei, Zhang, Ruitao, Yu, Jie, Zhang, Xinhao, Yin, Qi, JI, Chuanliang, Yue, Guidong, Liu, Mei, Xu, Jiake, Liu, Shimin, Jordana, Jordi, Noce, Antonia, Amills, Marcel, Wu, Dong Dong, Li, Shuaicheng, Zhou, Xiangshan, and Zhong, Jifeng

Abstract

Current knowledge about the evolutionary history of donkeys is still incomplete due to the lack of archeological and whole-genome diversity data. To fill this gap, we have de novo assembled a chromosome-level reference genome of one male Dezhou donkey and analyzed the genomes of 126 domestic donkeys and seven wild asses. Population genomics analyses indicate that donkeys were domesticated in Africa and conclusively show reduced levels of Y chromosome variability and discordant paternal and maternal histories, possibly reflecting the consequences of reproductive management. We also investigate the genetic basis of coat color. While wild asses show diluted gray pigmentation (Dun phenotype), domestic donkeys display non-diluted black or chestnut coat colors (non-Dun) that were probably established during domestication. Here, we show that the non-Dun phenotype is caused by a 1 bp deletion downstream of the TBX3 gene, which decreases the expression of this gene and its inhibitory effect on pigment deposition.

Published
2020

207. Three-dimensional ordered macropore structural TiO2 modified with Ni as photocatalysts

Author

Hu Wang, Penghui Bai, Kai Lei, Juan Xie, Xu Jiake, and Chenjie Wang

Subjects
Materials science, Metals and Alloys, chemistry.chemical_element, Surfaces and Interfaces, Microstructure, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Catalysis, chemistry.chemical_compound, Nickel, chemistry, Chemical engineering, Transition metal, Titanium dioxide, Materials Chemistry, Photocatalysis, Degradation (geology), Photodegradation
Abstract

The microstructure of catalysts and surface doped transition metals are the important factors that affect the photocatalytic performance a lot. In this study, Titanium dioxide (TiO2) photocatalysts with structure of three-dimensional ordered macropore (3DOM) were synthesized and modified with nickel (Ni) in order to enhance the photocatalytic performance of degradation methylene blue. The results suggested that the photodegradation rate of 3DOM structural TiO2 reached 82% when the degradation time was 60 min, which was greater than the disordered structural TiO2 of 47%, because of the special three-dimensional complex porous microstructure. The degradation rate of 3DOM structural TiO2 with modified Ni was as high as 94% when the degradation time was 30 min, which was greater than that of the disordered structural TiO2 (24%) and 3DOM structural TiO2 (56%). The effect of microstructure and Ni modification on photocatalytic performance was also discussed in this work.

Published
2021

210. Systemic Administration of Fibroblast Growth Factor 21 Improves the Recovery of Spinal Cord Injury (SCI) in Rats and Attenuates SCI-Induced Autophagy

Author

Zhu, Sipin, primary, Ying, Yibo, additional, Ye, Lin, additional, Ying, Weiyang, additional, Ye, Jiahui, additional, Wu, Qiuji, additional, Chen, Min, additional, Zhu, Hui, additional, Li, Xiaoyang, additional, Dou, Haicheng, additional, Xu, Huazi, additional, Wang, Zhouguang, additional, and Xu, Jiake, additional

Published
2021
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211. Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair

Author

Chen, Kai, primary, Liao, Shijie, additional, Li, Yicheng, additional, Jiang, Haibo, additional, Liu, Yun, additional, Wang, Chao, additional, Kuek, Vincent, additional, Kenny, Jacob, additional, Li, Boxiang, additional, Huang, Qian, additional, Hong, Jianxin, additional, Huang, Yan, additional, Chim, Shek Man, additional, Tickner, Jennifer, additional, Pavlos, Nathan J., additional, Zhao, Jinmin, additional, Liu, Qian, additional, Qin, An, additional, and Xu, Jiake, additional

Published
2021
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221. Hydrogen evolution performance of Ni loading on the carbon-based catalysts

Author

Xu Jiake, Juan Xie, Chenjie Wang, Penghui Bai, and Hu Wang

Subjects
Tafel equation, Materials science, Graphene, chemistry.chemical_element, Carbon black, Overpotential, Condensed Matter Physics, Catalysis, law.invention, Nickel, chemistry, Chemical engineering, law, General Materials Science, Cyclic voltammetry, Carbon
Abstract

High-performance hydrogen evolution catalysts are compelling for the conversion of energy. In this work, nickel particles were loaded on the surface of two kinds of carbon-based materials (graphene and Cabot conductive carbon black Vxc-72) by using a mild chemical method. The prepared Ni/Graphene and Ni/Vxc-72 show excellent hydrogen evolution reaction performance in 1.0 M KOH media. In particular, the overpotential of Ni/Graphene is only 29 mV (at 10 mA/cm2), and the Tafel slope is 87 mV/dec. It is also proved that Ni/Graphene has good stability by chronoamperometry and cyclic voltammetry. These findings suggest the loading nickel on the carbon-base catalysts can improve the hydrogen evolution performance.

Published
2021

222. Molecular structure, expression, and the emerging role of Siglec‐15 in skeletal biology and cancer.

Author

Rashid, Sarah, Song, Dezhi, Yuan, Jinbo, Mullin, Benjamin H., and Xu, Jiake

Subjects
MOLECULAR structure, PROGRAMMED death-ligand 1, BIOLOGY, ADAPTOR proteins, MEMBRANE proteins, OSTEOCLASTS
Abstract

Siglec‐15, a Siglec family member and type‐1 transmembrane protein, is expressed mainly in human macrophages and dendritic cells. It is comprised of a lysine‐containing transmembrane domain, two extracellular immunoglobulin (Ig)‐like domains and a short cytoplasmic domain. Siglec‐15 is highly conserved in vertebrates and acts as an immunoreceptor. It exerts diverse functions on osteoclast physiology as well as the tumor microenvironment. Siglec‐15 interacts with adapter protein DAP12 ‐ Syk signaling pathway to regulate the RANKL/RANK‐mediated PI3K, AKT, and ERK signaling pathways during osteoclast formation in vitro. Consistently, the lack of the Siglec‐15 gene in mice leads to impaired osteoclast activity and osteopetrosis in vivo. In addition, Siglec‐15 is expressed by tumor‐associated macrophages (TAMs) and regulates the tumor microenvironment by activating the SYK/MAPK signaling pathway. Interestingly, Siglec‐15 shares sequence homology to programmed death‐ligand 1 (PD‐L1) and has a potential immune‐regulatory role in cancer immunology. Thus, Siglec‐15 might also represent an alternative target for the treatment of cancers that do not respond to anti‐PD‐L1/PD‐1 immunotherapy. Understanding the role of Siglec‐15 in osteoclastogenesis and the tumor microenvironment will help us to develop new treatments for bone disorders and cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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223. Roburic acid attenuates osteoclastogenesis and bone resorption by targeting RANKL‐induced intracellular signaling pathways.

Author

Wang, Gang, Chen, Kai, Ma, Chao, Wang, Chao, Chen, Delong, He, Jianbo, Liu, Yuhao, Jiang, Tao, Yuan, Jinbo, Chen, Leilei, He, Wei, and Xu, Jiake

Subjects
BONE resorption, CELLULAR signal transduction, OSTEOCLASTOGENESIS, HEMOPROTEINS, HEME oxygenase, ADAPTOR proteins, EXTRACELLULAR signal-regulated kinases
Abstract

Excessive activity of osteoclasts contributes to skeletal diseases such as osteoporosis and osteolysis. However, current drugs targeting osteoclast have various deficiencies, placing natural compounds as substitutions of great potential. Roburic acid (RA) is a triterpenoid exacted from Radix Gentianae Macrophyllae, which exhibits inhibitory effects on inflammation and oxidation. By employing an in vitro osteoclastogenesis model, this study investigates the effects and mechanisms of RA on intracellular signaling induced by receptor activator of nuclear factor‐κB ligand (RANKL). As expected, RA at a concentration scope from 1 to 10 μM dampened the osteoclast differentiation of bone marrow macrophages (BMMs) but without cell toxicity. Interestingly, RA showed no effect on osteoblastogenesis in vitro. Furthermore, RA mitigated F‐actin ring formation, hydroxyapatite resorption, and gene expression in osteoclasts. Mechanistically, RA suppressed TNF receptor‐associated factor 6 (TRAF6), the crucial adaptor protein following RANKL‐RANK binding. On the one hand, RA downregulated the nuclear factor‐κB (NF‐κB) activity, extracellular regulated protein kinases (ERK) phosphorylation, and calcium oscillations. On the other hand, RA upregulated the antioxidative response element (ARE) response and the protein expression of heme oxygenase (HO)‐1. These upstream alterations eventually led to the suppression of the nuclear factor of activated T cells 1 (NFATc1) activity and the expression of proteins involved in osteoclastogenesis and bone resorption. Furthermore, by using an ovariectomized (OVX) mice model, RA was found to have therapeutic effects against bone loss. On account of these findings, RA could be used to restrain osteoclasts for treating osteoporosis and other osteolytic diseases. [ABSTRACT FROM AUTHOR]

Published
2022
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227. A missense mutation sheds light on a novel structure–function relationship of RANKL

Author

Qiu, Heng, primary, Qin, An, additional, Cheng, Taksum, additional, Chim, Shek M., additional, Smithers, Luke, additional, Chen, Kai, additional, Song, Dezhi, additional, Liu, Qian, additional, Zhao, Jinmin, additional, Wang, Chao, additional, Teguh, Dian, additional, Zhang, Ge, additional, Tickner, Jennifer, additional, Vrielink, Alice, additional, Pavlos, Nathan J., additional, and Xu, Jiake, additional

Published
2020
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229. Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Author

Chen, Delong, primary, Ye, Zhen, additional, Wang, Chao, additional, Wang, Qingqing, additional, Wang, Haibin, additional, Kuek, Vincent, additional, Wang, Ziyi, additional, Qiu, Heng, additional, Yuan, Jinbo, additional, Kenny, Jacob, additional, Yang, Fan, additional, He, Jianbo, additional, Liu, Yun, additional, Wang, Gang, additional, Zhang, Meng, additional, Zhang, Gangyu, additional, Wang, Junjian, additional, Chen, Peng, additional, and Xu, Jiake, additional

Published
2020
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230. Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways

Author

Liao, Shijie, primary, Feng, Wenyu, additional, Liu, Yun, additional, Wang, Ziyi, additional, Ding, Xiaofei, additional, Song, Fangming, additional, Lin, Xixi, additional, Song, Huijie, additional, KC, Anil, additional, Su, Yuangang, additional, Liang, Jiamin, additional, Xu, Jiake, additional, Liu, Qian, additional, and Zhao, Jinmin, additional

Published
2020
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232. Carnosol suppresses RANKL‐induced osteoclastogenesis and attenuates titanium particles‐induced osteolysis

Author

Li, Yongxian, primary, Lin, Sipeng, additional, Liu, Panjie, additional, Huang, Jianbin, additional, Qiu, Junxiong, additional, Wen, Zhenkang, additional, Yuan, Jinbo, additional, Qiu, Heng, additional, Liu, Yuhao, additional, Liu, Qian, additional, Zhou, Tengpeng, additional, Luo, Peijie, additional, Guo, Huizhi, additional, Ma, Yanhuai, additional, Guo, Danqing, additional, Mo, Guoye, additional, Tang, Yongchao, additional, Xu, Liangliang, additional, Liang, De, additional, Xu, Jiake, additional, Ding, Yue, additional, and Zhang, Shuncong, additional

Published
2020
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241. Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen‐Dependent Bone Loss in Mice

Author

Wang, Qingqing, primary, Chen, Delong, additional, Jin, Haiming, additional, Ye, Zhen, additional, Wang, Chao, additional, Chen, Kai, additional, Kuek, Vincent, additional, Xu, Ke, additional, Qiu, Heng, additional, Chen, Peng, additional, Song, Dezhi, additional, Zhao, Jinmin, additional, Liu, Qian, additional, Davis, Rohan A., additional, Song, Fangming, additional, and Xu, Jiake, additional

Published
2020
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244. Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Author

Mullin, Benjamin H., primary, Tickner, Jennifer, additional, Zhu, Kun, additional, Kenny, Jacob, additional, Mullin, Shelby, additional, Brown, Suzanne J., additional, Dudbridge, Frank, additional, Pavlos, Nathan J., additional, Mocarski, Edward S., additional, Walsh, John P., additional, Xu, Jiake, additional, and Wilson, Scott G., additional

Published
2020
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246. Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Author

Tian, Kun, primary, Su, Yuangang, additional, Ding, Jiaxin, additional, Wang, Dairong, additional, Zhan, Yunfei, additional, Li, Yicheng, additional, Liang, Jiamin, additional, Lin, Xixi, additional, Song, Fangming, additional, Wang, Ziyi, additional, Xu, Jiake, additional, Liu, Qian, additional, and Zhao, Jinmin, additional

Published
2020
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