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State-of-the-art lithium (Li)-ion batteries are approaching their specific energy limits yet are challenged by the ever-increasing demand of today’s energy storage and power applications, especially for electric vehicles. Li metal is considered an ultimate anode material for future high-energy rechargeable batteries when combined with existing or emerging high-capacity cathode materials. However, much current research focuses on the battery materials level, and there have been very few accounts of cell design principles. Here we discuss crucial conditions needed to achieve a specific energy higher than 350 Wh kg −1 , up to 500 Wh kg −1 , for rechargeable Li metal batteries using high-nickel-content lithium nickel manganese cobalt oxides as cathode materials. We also provide an analysis of key factors such as cathode loading, electrolyte amount and Li foil thickness that impact the cell-level cycle life. Furthermore, we identify several important strategies to reduce electrolyte-Li reaction, protect Li surfaces and stabilize anode architectures for long-cycling high-specific-energy cells.

BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease with limited therapeutic options. Recent studies have demonstrated that chemokines play a vital role in IPF pathogenesis. In the present study, we explored whether the gene signature associated with chemokines could be used as a reliable biological marker for patients with IPF.MethodsChemokine-related differentially expressed genes (CR-DEGs) in IPF and control lung tissue samples were identified using data from the Gene Expression Omnibus database. A chemokine-related signature of the diagnostic model was established using the LASSO-Cox regression. In addition, unsupervised cluster analysis was conducted using consensus-clustering algorithms. The CIBERSORT algorithm was used to calculate immune cell infiltration across patient subgroups. Finally, we established a mouse model of bleomycin-induced pulmonary fibrosis and a model of fibroblasts treated with TGFβ1. Expression levels of chemokine-related signature genes were determined using real-time quantitative polymerase chain reaction (RT-qPCR).ResultsWe established a chemokine-related eleven-gene signature of a diagnostic model consisting of CXCL2, CCRL2, ARRB1, XCL1, GRK5, PPBP, CCL19, CCL13, CCL11, CXCL6, and CXCL13, which could easily distinguish between IPF patients and controls. Additionally, we identified two subtypes of IPF samples based on chemokine-related gene expression. Pulmonary function parameters and stromal scores were significantly higher in subtype 1 than in subtype 2. Several immune cell types, especially plasma cells and macrophages, differ significantly between the two subtypes. RT-qPCR results showed that the expression levels of Cxcl2 and Ccl2 increased considerably in bleomycin-induced mice. Meanwhile, Arrb1, Ccrl2, Grk5, and Ppbp expression was significantly reduced. Furthermore, multiple chemokine-related genes were altered in TGFβ1 or TNFα-induced fibroblast cells.ConclusionsA novel chemokine-related eleven-signature of diagnostic model was developed. These genes are potential biomarkers of IPF and may play essential roles in its pathogenesis.

1.2 billion people and 90% of the national GDP are concentrated in China's seven river basins (RB7). Streamflow variation of RB7 caused by climate change and human disturbance posing a severe challenge to the water resources security situation in China. Quantifying streamflow changes under these two stresses is crucial for deeply understanding hydrologic process and reasonably utilizing water resource. The present study analyzed the trends of data series with Sen’s slope estimator and Mann-Kendall test, and quantified the influences of precipitation (P), potential evapotranspiration (ET0) and underlying surface parameter (ω) on streamflow variation by Budyko hypothesis-based elasticity coefficient method in 9 catchments controlled by mainstream hydrological stations from seven major river basins across China. Results showed that: Annual streamflow in LRB, YRB1, and HaiRB displayed significant downward trends of −0.16, −0.67 and −0.53 mm·y−1 during 1961–2020. Except for HuaiRB, the annual streamflow series of other catchments experienced significant mutations during 1984–2000. The elasticity coefficient εP ranged from 1.65 to 3.56, εET0 ranged from −2.56 to −0.65, and εω ranged from −3.79 to −0.52. A higher sensitivity of streamflow to P and ω, comparing to ET0. Streamflow in the north basins was more sensitive to driving factors than in the south basins across China. Variations in annual streamflow in LRB and YZRB were mainly ascribed to the changes in P, with the contribution rates ranging 65.1–162%, while the underlying surface change dominated the streamflow reduction in SHRB, HaiRB, HuaiRB, YRB, and PRB, with the contribution rates ranging 60.0–163%. ET0 had a weak effect on streamflow change in most basins. The change of underlying surface ω was largely due to vegetation cover changing, urbanization expanding, water consumption increasing and water conservancy constructing.

In order to make battery recycling process greener and more cost-effective, an innovative whole process electrolysis (WPE) concept is proposed in this work. Herein, proof-of-concept for the WPE battery recycling approach is carried out. A recycling routine producing PbI2 from spent lead-acid battery is designed based on the WPE concept. Details of the recycling routine is discussed, and zero energy consumption & zero waste generation for the whole process can be proved. The WPE battery recycling concept is expected to be an alternative choice to the traditional metallurgical battery recycling approach, to realize more sustainable battery recycling.

Abstract The tailings dam system is complex, and the dam structure changes continuously over time, which can make it difficult to identify key hazards of failure and characterize the accident formation process. To solve the above problems, based on complex network theory, the paper uses the identified hazards and the relationship between hazards to construct the propagation network of tailings dam failure risk (PNTDFR). The traditional analysis methods of network centrality usually focus on one aspect of the information of the network, while it cannot take into account to absorb the advantages of different methods, resulting in the difference between identified key nodes and real key hazards. To find the key hazards of tailing dam failure, based on the characteristics of multi-stage propagation of failure risk, the paper proposes a multi-stage collaborative hazard remediation method (MCHRM) to determine the importance of hazard nodes by absorbing the advantages of different centrality methods under different hazard remediation (deletion) ratios. The paper applies the above methods to Feijão Dam I. It can be found that when the priority remediation range is increased to 45%, the key hazards obtained by the MCHRM will cover all the causes of accidents proposed by the Dam I failure investigation expert group. Besides, the paper compares the monitoring data, daily inspection results and safety evaluation information of key hazards with the ‘Grading standards of hazard indicators’, and obtains the formation process of the Dam I failure and 30 key hazards in trigger state.

Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of benzene. It features special physical and chemical properties, and thus has the potential to serve as a new type of pharmacophore for drug design and discovery. Based on the relative positions of two cage carbons, icosahedral closo-carboranes can be classified into three isomers, ortho-carborane (o-carborane, 1,2-C2B10H12), meta-carborane (m-carborane, 1,7-C2B10H12), and para-carborane (p-carborane, 1,12-C2B10H12), and all of them can be deboronated to generate their nido- forms. Cage compound carborane and its derivatives have been demonstrated as useful chemical entities in antitumor medicinal chemistry. The applications of carboranes and their derivatives in the field of antitumor research mainly include boron neutron capture therapy (BNCT), as BNCT/photodynamic therapy dual sensitizers, and as anticancer ligands. This review summarizes the research progress on carboranes achieved up to October 2021, with particular emphasis on signaling transduction pathways, chemical structures, and mechanistic considerations of using carboranes.

Abstract Objective Esophageal carcinoma (ESCA) is deadly cancer worldwide with unknown etiology. This study aimed to investigate the impact and mechanism of RAD6 on the development of Esophageal squamous cell carcinoma (ESCC). Expressions of RAD6A and RAD6B in ESCA were investigated from TCGA dataset and their expressions in tissue sample of ESCA patients and cells were determined. Functional experiments were conducted to explore the impact of RAD6A and RAD6B on malignant characteristics of several kinds of ESCC cells. Animal experiment was established and injected with RAD6A and RAD6B shRNA to evaluate the effect on tumor growth. RAD6A and RAD6B were up-regulated in ESCC cells and tissues. Overexpressed RAD6A and RAD6B similarly increased ESCC cell proliferation, invasion and migration and silencing of RAD6 exerted opposite effects. Knockdown of RAD6A suppressed tumor growth and decreased the level of H2B, as data demonstrated positive correlation between RAD6A and CCNB1 in ESCC tissues. Collectively, this study elucidates that RAD6 is up-regulated in ESCC and promotes the progression of ESCC through up-regulation of CCNB1 to enhance H2B ubiquitination. These evidence provide a novel insight into the pathogenesis of ESCC and might contribute to the development of targeted therapy.

The high energy density advantage of lithium (Li) metal batteries (LMBs) makes them increasingly desirable; however, problems such as strong reactivity and dendrite growth of Li metal anode limit their practical uses. In this work, a novel Li‐containing glycerol (LiGL) or lithicone protection layer on a 50 μm thick Li metal anode is employed for improving the performance of LMBs. This LiGL layer was accurately deposited via a molecular layer deposition (MLD) process at 150 °C, using lithium tert‐butoxide and glycerol as precursors. The as‐formed LiGL coating layer is highly tunable in its thickness by simply adjusting MLD cycles and shows a good stability and outstanding ionic transport properties. The LiGL layer is found to effectively mitigate side reactions and enhance cycling stability in both symmetric cells and full cells. Specifically, the LMBs with LiGL@Li anode of 400 MLD cycles and LiNi0.6Mn0.2Co0.2O2 cathode enable a capacity retention of ≈87%, much higher than ≈35% of the cells with bare Li after 200 cycles at a charge/discharge current density of 2.1 mA cm−2. This work paves a feasible way for practical LMBs with improved capacity and stability through applying an innovative protection layer on Li metal anodes. [ABSTRACT FROM AUTHOR]

The lifespan of lithium (Li) metal batteries (LMBs) can be greatly improved by the formation of inorganic‐rich electrode‐electrolyte interphases (EEIs) (including solid‐electrolyte interphase on anode and cathode‐electrolyte interphase on cathode). In this work, a localized high‐concentration electrolyte containing lithium bis(fluorosulfonyl)imide (LiFSI) salt, 1,2‐dimethoxyethane (DME) solvent and 1,2‐bis(1,1,2,2‐tetrafluoroethoxy)ethane (BTFEE) diluent is optimized. BTFEE is a fluorinated ether with weakly‐solvating ability for LiFSI so it also acts as a co‐solvent in this electrolyte. It can facilitate anion decomposition at electrode surfaces and promote the formation of more inorganic‐rich EEI layers. With an optimized molar ratio of LiFSI:DME:BTFEE = 1:1.15:3, LMBs with a high loading (4 mAh cm−2) lithium nickel manganese cobalt oxide (LiNi0.8 Mn0.1 Co0.1) cathode can retain 80% capacity in 470 cycles when cycled in a voltage range of 2.8–4.4 V. The fundamental understanding on the functionality of BTFEE revealed in this work provides new perspectives on the design of practical high‐energy density battery systems. [ABSTRACT FROM AUTHOR]

Inverse Uncertainty Quantification (IUQ) has gained increasing attention in the field of nuclear engineering, especially nuclear thermal-hydraulics (TH), where it serves as an important tool for quantifying the uncertainties in the physical model parameters (PMPs) while making the model predictions consistent with the experimental data. In this paper, we present an extension to an existing Bayesian inference-based IUQ methodology by employing a hierarchical Bayesian model and variational inference (VI), and apply this novel framework to a real-world nuclear TH scenario. The proposed approach leverages a hierarchical model to encapsulate group-level behaviors inherent to the PMPs, thereby mitigating existing challenges posed by the high variability of PMPs under diverse experimental conditions and the potential overfitting issues due to unknown model discrepancies or outliers. To accommodate computational scalability and efficiency, we utilize VI to enable the framework to be used in applications with a large number of variables or datasets. The efficacy of the proposed method is evaluated against a previous study where a No-U-Turn-Sampler was used in a Bayesian hierarchical model. We illustrate the performance comparisons of the proposed framework through a synthetic data example and an applied case in nuclear TH. Our findings reveal that the presented approach not only delivers accurate and efficient IUQ without the need for manual tuning, but also offers a promising way for scaling to larger, more complex nuclear TH experimental datasets.

Business parks account for 30% of China’s total carbon emissions. Exploring emissions reduction approaches for business parks is crucial to achieve a net-zero emissions target, as well as for achieving a representative example for all types of emissions entities. Business parks mainly adopt two types of emissions reduction approaches: energy-saving renovations and purchasing carbon reduction products. However, there are limited studies focusing on the optimal combinations of the two approaches for reaching net-zero emissions and evaluating the cost effectiveness. To find a feasible and quantified way to build net-zero business park, a comprehensive path decision model is proposed. The problem is broken down into two parts: the optimal carbon reduction portfolio and the optimal electricity saving were researched. For the optimal product portfolio, the Markowitz theory is employed to balance the risk of carbon reduction products with the expected cost. In the part of optimal electricity saving, considering a ten-year life cycle, the total cost includes renovation investment, carbon reduction products cost, and cost saving of electricity consumption reduction. Based on the energy consumption, technical, and price data, the combination of energy-saving renovations and carbon reduction products is optimized. The model suggests a business park can save 24% of energy consumption through renovation investment and purchase CCER as 66% of the carbon reduction product portfolio. Taking only purchasing carbon reduction products as a benchmark to assess economic efficiency, implementing an optimized level of energy-saving renovation is found to save 16% of the comprehensive cost for the life cycle required to achieve zero carbon emissions. This model provides a new comprehensive optimization idea that will help future parks make decisions to achieve zero-carbon emission targets.

Epicenter locations are generally adjacent to active faults and past seismicity regions. Past earthquake catalogs and the geometry of the active faults can provide key prior knowledge concerning earthquake forecasts. In this study, we first introduce two straightforward dedicated models, the proximity-to-past-earthquakes (PPE) and proximity-to-mapped-faults (PMF) models, to fit the seismicity in the Sichuan-Yunnan region, China. The hybrid proximity-to-known-sources (PKS) model with the optimized model parameters is then used to estimate the probability of earthquake occurrence. Second, to compare the PKS forecast efficiency to those of different models, retrospective tests are applied to a dataset located in the Sichuan-Yunnan region. The results show that the probability maps derived from PPE, PMF, and PKS have non-uniform Poisson distribution features and that there is forecasting significance for past cases of moderate earthquakes in the test region. Finally, using Molchan error diagram tests, we find that the hybrid PKS model performs better than the other models in the testing region. The unsatisfactory performance of the PMF model for earthquake forecasting may lie both in the incompleteness of the fault database and the lack of consideration of co-seismic ruptures. Therefore, one of the three models can be used as a base model for comparing and evaluating earthquake forecast strategies.

The beam spreading, spectral degree of coherence and evolution behavior of the intensity profile of partially coherent Lorentz-Gaussian elliptical multi-Gaussian correlation Schell-Model beam propagating in anisotropic atmospheric turbulence are studied. The analytical expressions of cross-spectral density function, as well as root mean square (rms) beam width, are derived based on the extended Huygens-Fresnel principle and the relationship of Lorentz distribution and Hermitian Gaussian function. With the increases of propagation distance, the elliptical beam will first evolve into Gaussian beam and then change back to elliptical beam. In anisotropic atmospheric turbulence, the influence of the inner scale of turbulence on the spectral degree of coherence and rms beam width are obviously greater than that of the outer scale. For Lorentz-Gaussian elliptical multi-Gaussian correlated Schell-Model beams, better propagation performance was found in anisotropic atmospheric turbulence with larger anisotropic factor and smaller inner scale.

A large number of cracks exist in natural rock masses, which significantly affects the stability of surrounding rocks in engineering under impact loading. Repeated impact tests by Split Hopkinson Pressure Bar are performed on non-penetrating cracked granite specimens with different prefabricated-crack inclination angles (0, 30, 45, 60, and 90°). The damage evolution law of cracked rock under repeated impact loading is investigated. Macroscopic damage variables considering geometric and mechanical parameters of cracks are proposed. Further, a constitutive model for the impact loading test is developed based on the coupling damage. It has been found that, the impact resistance of fractured rock first decreases and then increases with the increased prefabricated-crack inclination angle. The impact resistance for specimens with an inclination angle of 45° is the minimum. Theoretical results from the developed model agree with the experimental data. The model could well describe the progressive damage characteristics of cracked rock masses.

The honey locusts (genus Gleditsia) are a genus of high-value trees in Asia. Seed beetle, Megabruchidius dorsalis (Fåhraeus) (Col.: Chrysomelidae: Bruchinae), is a Gleditsia oligophagous pest that causes severe yield reduction. To understand the cold tolerance of M. dorsalis adults, this study investigated its cold tolerance strategy and the influence of low temperatures on its physiology and biochemistry. The low-temperature treatments were divided into three groups: long-term temperature acclimation (Group 1; 15°C, or 20°C, or 25°C, or 28°C [control check, CK] for 10 days), short-term low-temperature exposure (Group 2; 0°C or 4°C for 2 h), and long-term low-temperature induction (Group 3; 0°C or 4°C for 1, 3, or 5 d). The supercooling point (SCP; temperature at which spontaneous nucleation and ice lattice growth begin), freezing point (FP; temperature at which insect fluids freeze), low lethal temperature (LLT; temperature at which all individuals are killed), water, lipid, glycerol, and total sugars contents were measured under different temperature stresses. The results showed that M. dorsalis adults were a freeze-avoidant species. The SCP and LLT at 28°C were −10.62°C and −19.48°C, respectively. The SCP and FP of long-term temperature acclimation (15°C, or 20°C, or 25°C) were significantly lower than that of the control group (28°C). The water content of the long-term low temperature induction (0°C) group was significantly lower than that of the control group. The lipid and glycerol content in the acclimated group at 20°C and 25°C were significantly higher than in the control group. M. dorsalis adults may maintain their biofluids in a supercooled state via cryoprotectant accumulation and cryoprotective dehydration to prevent ice nucleation. This study provides a theoretical basis for future research on overwintering and potential distribution and related prediction of M. dorsalis adults.

Geothermal reservoirs are reformed by thermal and chemical stimulation combined with hydrofracture, which is more effective in forming artificial fracture networks. It is critical for the efficient development of geothermal resources to understand the changes in the physical properties of hot dry rock (HDR) during reservoir reconstruction. Granite samples subjected to thermal stimulation at different temperatures are conducted with static immersion tests of different chemical solutions for 48 days to study the effects of thermal and chemical stimulation on HDR. P-wave velocities, porosity, and thermophysical parameters (thermal conductivity and thermal diffusivity) of thermal-chemical-modified granite are measured by ultrasonic testing (UT), nuclear magnetic resonance (NMR), and transient plane source (TPS), respectively. The effects of different heat-treatment temperatures and chemical solutions on the physical properties of granites are studied. After that, the functional relationship between the physical parameters and heat-treatment temperature is quantitatively characterized, and the correlation between the different physical parameters is analyzed. The thermal and chemical damage mechanisms of granite are revealed from its physical properties, pore structures, and mineral compositions. Results showed that thermal stimulation is more likely to change the physical properties of granites than chemical stimulation, and the physical properties significantly changed at a temperature threshold of 300°C. The mass of thermal-chemical-modified granites decreased with the increased heat-treatment temperature; the P-wave velocity decreased linearly; the porosity increased nonlinearly; the thermal conductivity decreased exponentially; the thermal diffusivity decreased linearly. Porosity increased with the decreased P-wave velocity, which presented a nonlinear relationship. The thermophysical parameters are negatively correlated with porosity and positively correlated with the P-wave velocity. The acid solution stimulation further caused the decreased P-wave velocity and increased porosity of heat-treated granite samples, which reduced the thermal conductivity of samples. However, the alkaline solution stimulation is the opposite. The pore structure development and phase transformation are the essential reasons for the changes in the physical properties of thermal-chemical-modified granites.

To enable next-generation high-energy-density lithium (Li)-metal batteries (LMBs), an electrolyte that has simultaneous high Li-metal Coulombic efficiency (CE) and high anodic stability on cathodes is of significant importance. Sulfones are known for strong resistance against oxidation, yet their application in LMBs is restricted because of their poor compatibility with Li-metal anodes, high viscosity, and poor wettability. Here, we demonstrate that a high Li CE over 98% can be achieved in concentrated sulfone-based electrolytes. Furthermore, the viscosity and wettability issues of sulfones are resolved by the addition of a fluorinated ether, 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether, to form a localized high-concentration electrolyte (LHCE), which not only provides further improvement in Li CE (98.8%) but also remains anodically stable with high-voltage cathodes, suppresses Al corrosion, and enables LMBs to operate in a wide temperature range. As a result, significantly improved cycling performance of LMBs has been realized with sulfone-based LHCE. For high-voltage rechargeable lithium (Li)-metal batteries (LMBs), electrolytes with good stabilities on both the highly oxidative cathodes and the highly reductive Li-metal anodes are urgently desired. Sulfones have excellent oxidative stability, yet their high viscosity, poor wettability, and, in particular, incompatibility with Li anodes greatly hinder their applications in LMBs. Here, we demonstrate that a high Li Coulombic efficiency (CE) of 98.2% during repeated Li plating and stripping cycles can be realized in concentrated lithium bis(fluorosulfonyl)imide (LiFSI)-tetramethylene sulfone electrolyte. More importantly, the localized high-concentration electrolyte, formed by the dilution of the high-concentration electrolyte with a non-solvating fluorinated ether, 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether, solves the viscosity and wettability issues, further improves Li CE (98.8%), and improves the high-voltage (4.9 V) performance of LMBs with effective Al protection. High-voltage batteries with Li-metal anodes can offer desirable high energy densities. Despite their excellent oxidative stability, sulfones have various limitations to be useful in Li-metal batteries, in particular their instability with Li metal. Here, we achieved a high Li Coulombic efficiency of nearly 99% in a sulfone-based localized high-concentration electrolyte (LHCE) with the addition of a non-solvating co-solvent. In addition, this co-solvent is highly beneficial for realizing stable battery cycling up to 4.9 V.

Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low cellular oxygen levels, are often overexpressed and activated in breast cancer. HIFs modulate the primary transcriptional response of downstream pathways and target genes in response to hypoxia, including glycolysis, angiogenesis and metastasis. They can promote the development of breast cancer and are associated with poor prognosis of breast cancer patients by regulating cancer processes closely related to tumor invasion, metastasis and drug resistance. Thus, specific targeting of HIFs may improve the efficiency of cancer therapy. In this review, we summarize the advances in HIF-related molecular mechanisms and clinical and preclinical studies of drugs targeting HIFs in breast cancer. Given the rapid progression in this field and nanotechnology, drug delivery systems (DDSs) for HIF targeting are increasingly being developed. Therefore, we highlight the HIF related DDS, including liposomes, polymers, metal-based or carbon-based nanoparticles.

Lithium metal has been considered the "holy grail" anode material for rechargeable batteries despite the fact that its dendritic growth and low Coulombic efficiency (CE) have crippled its practical use for decades. Its high chemical reactivity and low stability make it difficult to explore the intrinsic chemical and physical properties of the electrochemically deposited lithium (EDLi) and its accompanying solid electrolyte interphase (SEI). To prevent the dendritic growth and enhance the electrochemical reversibility, it is crucial to understand the nano- and mesostructures of EDLi. However, Li metal is very sensitive to beam damage and has low contrast for commonly used characterization techniques such as electron microscopy. Inspired by biological imaging techniques, this work demonstrates the power of cryogenic (cryo)-electron microscopy to reveal the detailed structure of EDLi and the SEI composition at the nanoscale while minimizing beam damage during imaging. Surprisingly, the results show that the nucleation-dominated EDLi (5 min at 0.5 mA cm-2) is amorphous, while there is some crystalline LiF present in the SEI. The EDLi grown from various electrolytes with different additives exhibits distinctive surface properties. Consequently, these results highlight the importance of the SEI and its relationship with the CE. Our findings not only illustrate the capabilities of cryogenic microscopy for beam (thermal)-sensitive materials but also yield crucial structural information on the EDLi evolution with and without electrolyte additives.

Abstract Circular RNA (circRNA), a closed continuous loop formed by back-splicing, has been confirmed to be implicated in a variety of human diseases including cancers. However, the underlying molecular mechanism of circRNA regulating the progression of renal cell carcinoma (RCC) remains largely unclear. In the present study, we identified a novel circular RNA, circESRP1, that derived from the ESRP1 gene locus at 8q22.1 exons. Lower expression of circESRP1 was found in clear cell RCC (ccRCC) tissues and cell lines. Besides, circESRP1 expression level showed inversely correlated with the advanced tumor size, TNM stage and distant metastasis of ccRCC. The expression level of circESRP1 exhibited a positive correlation with CTCF protein but negatively correlated with miR-3942 in 79 ccRCC tissues. In vivo experiments, we found that overexpression of circESRP1 effectively repressed xenograft tumor growth and inhibited c-Myc-mediated EMT progression. CircESRP1 acted as a sponge to competitively bind with miR-3942 as confirmed through RNA pull-down, RIP and dual-luciferase reporter assays. Moreover, CTCF, a downstream target of miR-3942, was validated to specifically promote the circESRP1 transcript expression and regulated by circESRP1/miR-3942 pathway to form a positive feedback loop. We also revealed that the circESRP1/miR-3942/CTCF feedback loop regulated the ccRCC cell functions via c-Myc mediated EMT process. This study provides a novel regulatory model of circRNA via forming a positive-feedback loop that perpetuates the circESRP1/miR-3942/CTCF axis, suggesting that this signaling may serve as a novel target for the treatment of ccRCC.

Rib fracture is the most common injury in chest trauma. Most of patients with rib fractures were treated conservatively, but up to 50% of patients, especially those with combined injury such as flail chest, presented chronic pain or chest wall deformities, and more than 30% had long-term disabilities, unable to retain a full-time job. In the past two decades, surgery for rib fractures has achieving good outcomes. However, in clinic, there are still some problems including inconsistency in surgical indications and quality control in medical services. Before the year of 2018, there were 3 guidelines on the management of regional traumatic rib fractures were published at home and abroad, focusing on the guidance of the overall treatment decisions and plans; another clinical guideline about the surgical treatment of rib fractures lacks recent related progress in surgical treatment of rib fractures. The Chinese Society of Traumatology, Chinese Medical Association, and the Chinese College of Trauma Surgeons, Chinese Medical Doctor Association organized experts from cardiothoracic surgery, trauma surgery, acute care surgery, orthopedics and other disciplines to participate together, following the principle of evidence-based medicine and in line with the scientific nature and practicality, formulated the Chinese consensus for surgical treatment of traumatic rib fractures (STTRF 2021). This expert consensus put forward some clear, applicable, and graded recommendations from seven aspects: preoperative imaging evaluation, surgical indications, timing of surgery, surgical methods, rib fracture sites for surgical fixation, internal fixation method and material selection, treatment of combined injuries in rib fractures, in order to provide guidance and reference for surgical treatment of traumatic rib fractures.

Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization. With no curative therapy for IBD at present, the development of effective therapeutics is highly advocated. Drug delivery systems have been extensively studied to transmit therapeutics to inflamed colon sites through the enhanced permeability and retention (EPR) effect caused by the inflammation. However, the drug still could not achieve effective concentration value that merely utilized on EPR effect and display better therapeutic efficacy in the inflamed region because of nontargeted drug release. Substantial researches have shown that some specific receptors and cell adhesion molecules highly expresses on the surface of colonic endothelial and/or immune cells when IBD occurs, ligand-modified drug delivery systems targeting such receptors and cell adhesion molecules can specifically deliver drug into inflamed sites and obtain great curative effects. This review introduces the overexpressed receptors and cell adhesion molecules in inflamed colon sites and retrospects the drug delivery systems functionalized by related ligands. Finally, challenges and future directions in this field are presented to advance the development of the receptor-mediated targeted drug delivery systems for the therapy of IBD.

Abstract This study investigated the effects of electro-dewatering on subsequent low-temperature drying at various potentials and the characteristics of low-temperature air-drying sludge were explored through experiments and multi-physical modeling. Experimental results showed that the extracellular polymeric substance (EPS) content in the sludge was reduced during electro-dewatering process, even the species of organic matter was changed, as well as the dewatered cake tend to form many seepage channels, crack and a certain number of holes. These changes in the properties and structure were conducive to the subsequent low-temperature drying process. For air-drying process, the mass of the sludge cake variation was simulated and results were consistent with the experimental phenomenon. Firstly, the weight of the sludge cake was decreased approximately linearly with time, then tended to stable and reached the dewatering limitation finally. The applied higher electric field intensity (25 V cm−1) in the front-end electro-dewatering were conducive to promote water vapor diffusion activity in air-drying stage. Energy consumption and yield analysis results indicated that the combined technology has lower energy consumption and higher yield than that of directly low-temperature drying.