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Isotopic ratios of radioxenons sampled in the atmosphere or subsurface can be used to verify the occurrence of an underground nuclear explosion (UNE). Differences in the half-lives of radioactive xenon precursors and their decay-chain networks produce different time-dependent concentration profiles of xenon isotopes allowing isotopic ratios to be used for tracking UNE histories including estimating the time of detonation. In this study, we explore the potential effects of post-detonation cavity processes: precipitation of iodine precursors, gas seepage, and prompt venting on radioxenon isotopic evolution which influences UNE histories. Simplified analytical models and closed-form solutions yielding a potentially idealized radioactive decay/ingrowth chain in a closed and well-mixed system typically have limited application by not including the partitioning of the radionuclide inventory between a gas phase and rock melt created by the detonation and by ignoring gas transport from the cavity to host rock or ground surface. In reality, either subsurface transport or prompt release that is principally responsible for gas signatures violates the closed-system (or batch-mode) assumption. A closed-form solution representing time-dependent source-term activities is extended by considering the cavity partitioning process, slow seepage, and/or prompt release of gases from the cavity and applied to realistic systems. [ABSTRACT FROM AUTHOR]

Pulsed xenon lamp is often used for performance testing of solar cells because its spectrum is most similar to sunlight. The pulsed xenon lamp power supply is the key factor to ensure the reliable operation of the pulsed xenon lamp and improve the photoelectric conversion efficiency. In order to solve the problems of the traditional pulsed xenon lamp power supply with large volume, large noise interference and low reliability, a highreliability pulsed xenon lamp power supply was designed. Staggered parallel Buck was adopted to reduce the output ripple, and the digital control scheme of the improved nested working sequence was used to improve the working reliability of the pulsed xenon lamp. By building an experimental prototype and testing, it is proved that the pulsed power supply can make the pulsed xenon lamp light up 100% and keep working stably. [ABSTRACT FROM AUTHOR]

Quantum-mechanical simulations of the nonlinear response of a one-dimensional quantum system with the energy structure close to that of the xenon atom to an ultraviolet femtosecond pulse with an intensity of 1–100 TW/cm2 reveal the dispersion of the cubic nonlinearity coefficient in the range of 266–400 nm and its intensity dependence. This excludes the description of the response of bound electrons as . The calculation of the polarization with this one-dimensional quantum model can be used to simulate the propagation of ultraviolet femtosecond radiation in a gas. [ABSTRACT FROM AUTHOR]

The optical radiation in a gaseous medium upon the irradiation of a lithium layer with a fast electron beam of a 5 ns duration has been studied. The irradiation chamber was filled with argon, krypton, or xenon at a pressure of 10 kPa up to 60 kPa. The lines of lithium atoms appear in the emission spectrum at a lithium layer temperature of 650–680 K, and the intensity of these lines sharply increases with the increasing temperature of the lithium layer. The optical radiation arises from both the transitions of noble gas atoms and the transition of the lithium atom in a time of about 20–30 ns. The duration of the radiation pulses at half maximum at temperatures above 800 K was 60–100 ns at a wavelength of 610.4 nm and 140–220 ns at 670.8 nm in krypton and argon. The various mechanisms for the population of lithium levels during the radiation pulse are discussed. [ABSTRACT FROM AUTHOR]

In a previous study, in silico screening of the binding of almost all proteins in the Protein Data Bank to each of the five noble gases xenon, krypton, argon, neon, and helium was reported. This massive and rich data set requires analysis to identify the gas-protein interactions that have the best binding strengths, those where the binding of the noble gas occurs at a site that can modulate the function of the protein, and where this modulation might generate clinically relevant effects. Here, we report a preliminary analysis of this data set using a rational, heuristic score based on binding strength and location. We report a partial prioritized list of xenon protein targets and describe how these data can be analyzed, using arginase and carbonic anhydrase as examples. Our aim is to make the scientific community aware of this massive, rich data set and how it can be analyzed to accelerate future discoveries of xenon-induced biological activity and, ultimately, the development of new "atomic" drugs. [ABSTRACT FROM AUTHOR]

Changes in the structure of polycrystalline indium oxide after irradiation with xenon ions with energies of 140 and 300 keV have been studied. Irradiation with xenon ions was found to change the chemical composition of indium oxide, was accompanied by phase transformations, increased the intensity of reflected x-ray lines of the indium oxide structure, and increased the unit-cell constant over the depth of the sample. The x-ray method was used to separate the elastic and inelastic effects of xenon ions on the structure of indium oxide. The concentration of xenon ions dissolved over the depth of the sample was determined as a function of the irradiation energy. A structural model of the dissolution of xenon ions in the indium oxide lattice was presented and explained the formation of an ionic bond of xenon with indium and oxygen atoms and anionic vacancies. The intercalation of xenon ions into the octahedral positions of indium oxide led to the formation of an interstitial solid solution based on indium oxide along the depth of the sample. The energy of defect formation in the structure of indium oxide after irradiation of the samples was found to depend on the dose of xenon ions and the irradiation energy. Experimental and theoretical calculations were made to determine the lattice parameter and ionic radius of xenon in the XeO2 compound. The correct formation mechanism of an interstitial solid solution based on indium oxide was found. A mathematical model that explains the increase in the reflected x-ray intensity of indium oxide lines over the depth of the sample after irradiation with xenon ions was calculated. [ABSTRACT FROM AUTHOR]

To characterize morphology and physicochemical properties of nanolayers the surface-sensitive X-ray spectroscopy techniques are often successfully applied. These techniques are still being developed in order to achieve better depth resolution and detection limits. In this article, we present measurements of morphology of Ti nanolayers (deposited on Si substrate) with thickness of 25 nm, 50 nm and 75 nm, unmodified and irradiated with Xeq＋ ions (where q is the charge state of the ion), which were carried out using synchrotron radiation (SR) based XRR technique. The nanolayers were irradiated with low-energy (of the order of hundreds of keV) highly charged Xeq＋ (q = 25, 30, 35) ions, at the Kielce EBIS facility (Jan Kochanowski University, Kielce, Poland). The SR-XRR measurements were performed at Elettra Synchrotron X-ray fluorescence beamline, using X-ray beam with energy of 6.0 keV. The obtained reflectivity curves were modelled by creating a structure consisting (from the bottom to the top) of silicon substrate (Si), main Ti layer, TiO 2 layer, and TiO 2 (a) amorphous layer, with contamination of hydrocarbons, carboxylates or alkoxides. The experimental results obtained with the SR-XRR technique for the nanolayers, unmodified and irradiated with the Xeq＋, show the dependence of the TiO 2 layers morphology on the Xe ions charge state. In the article the sample preparation, measurement using SR-XRR and the data analysis procedures are described in details and the advantages and disadvantages of the SR-XRR technique in the context of nanolayer studies are discussed. [ABSTRACT FROM AUTHOR]

The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsin (pH 1.2). Inhalation of the oxygen-xenon mixture inhibited the development and reduced the intensity of the inflammatory process in the lung tissue, which was assessed by the dynamics of lung weight and body weight of animals: the therapeutic exposure decreased both parameters. It was found that the thrombogenic stimulus, pathognomonic for the development of acute respiratory distress syndrome, decreased under the effect of oxygen-xenon inhalations, while the level of natural anticoagulant antithrombin III increased. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Culture & Haci Bektas Veli Research Quarterly is the property of Turkish Cultur & Haci Bektas Veli Research Quarterly and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: This study aimed to assess the color stability of resin cements subjected to xenon radiation and evaluate their color change (ΔE) during time. Materials and Methods: In this in vitro experimental study, 15 specimens (8 mm in diameter and 2 mm in height) were made from a light-cured resin cement (Choice 2, Bisco, USA) and two dual-cured resin cements (Panavia F2 and V5, Kuraray Co, Ltd, Osaka, Japan). For assessment of color change, ΔE parameters were measured immediately (ΔE1) and 24 h (ΔE2) after polymerization using XRiteCi64 spectrophotometer. Next, they were subjected to xenon lamp radiation (122 h at 35C° and 22% humidity in off mode and 95% in light mode). Then, their color change was measured again (ΔE3). The mean ΔE and standard deviation of all specimens were calculated, and data analysis was done using analysis of variance and Tukey's honestly significant difference. Results: L* values had a tendency to decrease and Panavia F2 and Choice 2 had the highest change after accelerated aging. The comparison of Δa and Δb showed no significant difference between cements except Δa in Panavia F2. All the values were clinically acceptable (ΔE >3.3). The lowest Δ E1 was for Panavia V5 and the highest Δ E1 was measured for Panavia F2. After accelerated aging, there was no significant difference between Panavia V5 and choice 2 (P > 0/05). Conclusions: Following polymerization and under xenon radiation, ΔE of all the specimens was clinically acceptable. [ABSTRACT FROM AUTHOR]

Abstract The interface between two‐dimensional (2D) crystals often forms a Moiré superstructure that imposes a new periodicity, which is a key element in realizing complex electronic phases as evidenced in twisted bilayer graphene. Acombined angle‐resolved photoemission spectroscopy measurements and first‐principles calculations reveal the formation of a Moiré superstructure between a 2D Dirac semi‐metallic crystal, graphene, and a 2D insulating crystal of noble gas, xenon. Incommensurate diffraction pattern and folded Dirac cones around the Brillouin zone center imply the formation of hexagonal crystalline array of xenon atoms. The velocity of Dirac fermions increases upon the formation of the 2D xenon crystal on top of graphene due to the enhanced dielectric screening by the xenon over‐layer. These findings not only provide a novel method to produce a Moiré superstructure from the adsorption of noble gas on 2D materials, but also to control the physical properties of graphene by the formation of a graphene‐noble gas interface.

IntroductionXenon exhibits significant neuroprotection against a wide range of neurological insults in animal models. However, clinical evidence that xenon improves outcomes in human studies of neurological injury remains elusive. Previous reviews of xenon's method of action have not been performed in a systematic manner. The aim of this review is to provide a comprehensive summary of the evidence underlying the cellular interactions responsible for two phenomena associated with xenon administration: anesthesia and neuroprotection.MethodsA systematic review of the preclinical literature was carried out according to the PRISMA guidelines and a review protocol was registered with PROSPERO. The review included both in vitro models of the central nervous system and mammalian in vivo studies. The search was performed on 27th May 2022 in the following databases: Ovid Medline, Ovid Embase, Ovid Emcare, APA PsycInfo, and Web of Science. A risk of bias assessment was performed utilizing the Office of Health Assessment and Translation tool. Given the heterogeneity of the outcome data, a narrative synthesis was performed.ResultsThe review identified 69 articles describing 638 individual experiments in which a hypothesis was tested regarding the interaction of xenon with cellular targets including: membrane bound proteins, intracellular signaling cascades and transcription factors. Xenon has both common and subtype specific interactions with ionotropic glutamate receptors. Xenon also influences the release of inhibitory neurotransmitters and influences multiple other ligand gated and non-ligand gated membrane bound proteins. The review identified several intracellular signaling pathways and gene transcription factors that are influenced by xenon administration and might contribute to anesthesia and neuroprotection.DiscussionThe nature of xenon NMDA receptor antagonism, and its range of additional cellular targets, distinguishes it from other NMDA antagonists such as ketamine and nitrous oxide. This is reflected in the distinct behavioral and electrophysiological characteristics of xenon. Xenon influences multiple overlapping cellular processes, both at the cell membrane and within the cell, that promote cell survival. It is hoped that identification of the underlying cellular targets of xenon might aid the development of potential therapeutics for neurological injury and improve the clinical utilization of xenon.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: 336871.

Xenon, an inert gas commonly used in medicine, has been considered as a potential option for prolonged preservation of donor packed red blood cells (pRBCs) under hypoxic conditions. This study aimed to investigate how xenon affects erythrocyte parameters under prolonged storage. In vitro model experiments were performed using two methods to create hypoxic conditions. In the first method, xenon was introduced into bags of pRBCs which were then stored for 42 days, while in the second method, xenon was added to samples in glass tubes. The results of our experiment showed that the presence of xenon resulted in notable alterations in erythrocyte morphology, similar to those observed under standard storage conditions. For pRBC bags, hemolysis during storage with xenon exceeded the acceptable limit by a factor of six, whereas the closed-glass-tube experiment showed minimal hemolysis in samples exposed to xenon. Notably, the production of deoxyhemoglobin was specific to xenon exposure in both cell suspension and hemolysate. However, this study did not provide evidence for the purported protective properties of xenon.

Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine in full concordance with personalized medicine. A wide range of hyperpolarized (HP) 129Xe biosensors have been recently developed, demonstrating their potential applications in molecular settings, and achieving notable success within in vitro studies. The favorable nuclear magnetic resonance properties of 129Xe, coupled with its non-toxic nature, high solubility in biological tissues, and capacity to dissolve in blood and diffuse across membranes, highlight its superior role for applications in molecular MRI settings. The incorporation of reporters that combine signal enhancement from both hyperpolarized 129Xe and chemical exchange saturation transfer holds the potential to address the primary limitation of low sensitivity observed in conventional MRI. This review provides a summary of the various applications of HP 129Xe biosensors developed over the last decade, specifically highlighting their use in MRI. Moreover, this paper addresses the evolution of in vivo applications of HP 129Xe, discussing its potential transition into clinical settings.

We present measurements from laser-produced plasmas generated using cryogenic Xe targets and quantify the emission characteristics in the soft x-ray region (1 to 6 nm). The system is based on a LN2-cooled rotating drum, which allows for a high repetition rate, and Nd:YAG laser systems with energies up to 325 mJ on-target with pulse lengths of 130 ps, 600 ps, or 6.5 ns. High resolution spectra are measured using a grazing incidence spectrometer, and we present the first quantitative conversion efficiency (CE) measurements for Xe in this range. Data show CE values up to ∼1% at 6 nm and ∼0.08% at 1.5 nm (for 2% bandwidth and 2π solid angle), and there are lower limits on the required laser intensities and energies on target to achieve these efficiencies. In addition, the emission spot size is directly measured at 2 nm (620 eV) using a point-projection slit imaging method, with optimized emission spot sizes of ∼20 μm. [ABSTRACT FROM AUTHOR]

The nature of irradiation-induced precipitates and their interaction with helium bubbles in a nickel-based Hastelloy N alloy were investigated using helium and subsequent xenon ions irradiation at 650 °C. The irradiation by xenon ions has induced the formation of precipitates which were identified as the Mo-Cr enriched M2C-type carbides with a hexagonal close-packed structure. The different behaviors of helium bubbles inside and outside of the precipitates were quantified by bubble size and density. The coupling mechanism between the bubble evolution and precipitate growth under irradiation-induced cascades was unveiled. This work will benefit a further quantitative model describing the interaction between the helium bubbles and growing precipitates under irradiation. [ABSTRACT FROM AUTHOR]

The development of sensitive and chemically selective MRI contrast agents is imperative for the early detection and diagnosis of many diseases. Conventional responsive contrast agents used in 1 H MRI are impaired by the high abundance of protons in the body. 129 Xe hyperCEST NMR/MRI comprises a highly sensitive complement to traditional 1 H MRI because of its ability to report specific chemical environments. To date, the scope of responsive 129 Xe NMR contrast agents lacks breadth in the specific detection of small molecules, which are often important markers of disease. Herein, we report the synthesis and characterization of a rotaxane-based 129 Xe hyperCEST NMR contrast agent that can be turned on in response to H2 O2 , which is upregulated in several disease states. Added H2 O2 was detected by 129 Xe hyperCEST NMR spectroscopy in the low micromolar range, as well as H2 O2 produced by HEK 293T cells activated with tumor necrosis factor.

The development of sensitive and chemically selective MRI contrast agents is imperative for the early detection and diagnosis of many diseases. Conventional responsive contrast agents used in 1 H MRI are impaired by the high abundance of protons in the body. 129 Xe hyperCEST NMR/MRI comprises a highly sensitive complement to traditional 1 H MRI because of its ability to report specific chemical environments. To date, the scope of responsive 129 Xe NMR contrast agents lacks breadth in the specific detection of small molecules, which are often important markers of disease. Herein, we report the synthesis and characterization of a rotaxane-based 129 Xe hyperCEST NMR contrast agent that can be turned on in response to H2 O2 , which is upregulated in several disease states. Added H2 O2 was detected by 129 Xe hyperCEST NMR spectroscopy in the low micromolar range, as well as H2 O2 produced by HEK 293T cells activated with tumor necrosis factor.

Xenon possesses some, but not all, of the clinical features of an ideal anesthetic agent. Besides well-known advantages of rapid awakening, stable hemodynamics and lack of biotransformation, preclinical data lead to the expectation of xenon's advantageous use for settings of acute ongoing brain injury; a single randomized clinical trial using an imaging biomarker for assessing brain injury corroborated xenon's preclinical efficacy in protecting the brain from further injury. In this review, we discuss the mechanisms and hence the putative applications of xenon for brain protection in neurosurgery. Although the expense of this rare monoatomic gas will likely prevent its widespread penetration into routine clinical neurosurgical practice, we draw attention to the theoretical benefits of xenon anesthesia over other anesthetic regimens for awake craniotomy and for neurosurgery in older, high-risk, and sicker patients.

Gas-filled proportional detectors of ionizing radiation often contain such elements as thin anode wire, which make them sensitive to external acoustic or vibrational impact. This study investigates such sensitivity for the case of the proportional γ-radiation detectors filled with high-purity xenon gas. The detector demonstrates a dependence of its signal noise on the external acoustic wave frequency, the character of which most likely depends on the design of the detector, i.e. on such parameters as diameter and tension strength of the anode wire, etc. To suppress the negative impact of acoustic noise on the characteristics of the detector, the detector digital signal is processed in a Field-Programmable Gate Array board. The authors investigate the algorithm of «time windows», which allows separating (filtering) low-frequency noise in the output signal of a gas-filled detector, which arises due to the influence of external sound, from the useful signal, i.e. the ionization pulses. This approach allows performing spectral measurements of γ-radiation with a significant acoustic noise background, when detectors with a conventional analog spectrometric channel cannot handle the task.

Kirkwood–Buff Integral (KBI) theory is an important method for the analysis of the structural and thermodynamic properties of liquid solutions. For solids, the calculation of KBIs has become possible only recently through the finite-volume generalisation of KBI theory, but it has so far only been applied to monoatomic crystals. Here, we show that KBI theory can be applied to solid mixtures and compute the KBIs of a ArxXe1−x solid solution, for 0

Management of elderly and senile patients is a major challenge due to significant comorbidity, especially in surgery under general anesthesia.The aim of the review was to identify the optimal method of anesthesia for knee arthroplasty in elderly patients based on the available clinical and experimental studies.We searched PubMed, Medline, and Elibrary.ru databases for relevant sources. Out of more than 300 publications initially analyzed, 113 literature sources (dating from 1951 to 2021) were included in the review, of which 80 were published within the last five years (2016–2021). The inclusion criteria were high informative value and relevance, except for sources cited as historical references. Both randomized multicenter studies and individual case reports were included in the review. Exclusion criteria were low informative value, outdated and repetitive data.We reviewed the physiology of elderly and senile patients, various variants of anesthesia, the use of neuroaxial anesthesia and peripheral regional blocks, xenon-based general anesthesia, assessed the advantages and drawbacks of each method, and discussed the monitoring of the depth of anesthesia and the issues of inraoperative awareness during knee arthroplasty in elderly and senile patients.Conclusion. The choice of anesthesia for knee arthroplasty in elderly and senile patients should be based on the risks of decompensation of cardiovascular comorbidities and cognitive impairment. No known anesthetic method is ideal in terms of safety. The use of xenon as the main anesthetic seems promising due to its cardio- and neuroprotective properties. However, its use is limited due to relatively high cost. Therefore, the search for optimal (lower than recommended) inhalation concentrations may lead to expanding use of xenon in elderly and senile patients. At the same time, the use of lower concentrations of the drug is associated with the intraoperative awakening and the need for its combination with narcotic analgesics or amnestic agents, which may not be optimal. In addition, the protective effect of xenon retrograde amnesia against the stress of unintended intraoperative awakening has not been studied, and routine methods of monitoring the depth of hypnosis when using xenon often yield skewed measurement results inconsistent with the clinical manifestations of anesthesia.Therefore, there is a need for further studies concerning the retrograde amnesic effect of xenon and search for optimal methods of assessing the depth of hypnosis when using this gas to safely reduce its inhalation concentration.

This document is a corrigendum for an article titled "Xenon attenuated neonatal lipopolysaccharide exposure induced neuronal necroptosis and subsequently improved cognition in juvenile rats." The corrigendum acknowledges an error in Figure 3 of the original article and provides the corrected figure. The authors apologize for the error and state that it does not affect the scientific conclusions of the article. The corrigendum also includes contact information for the authors and information about the publication and copyright. [Extracted from the article]

Background: Xenon and argon inhalation were included on the WADA Prohibited List in 2014 due to the reported positive effects on erythropoiesis and steroidogenesis that occur as a result of their application. Thus, the systematic review of studies supporting these notions is of interest. Methods: A thorough search on the effects of xenon and argon inhalation on erythropoiesis and steroidogenesis, as well as their negative effects on human health and method detection was conducted. Pubmed and Google Scholar databases and the Cochrane Library were researched, as well as the WADA research section. The search was conducted in accordance with the PRISMA guidelines. All articles written in English and published between 2000 and 2021 were analyzed, as well as reference studies meeting the search criteria. Results: At present, there are only two publications in healthy human subjects evaluating the effects of xenon inhalation on erythropoiesis that found no conclusive evidence of a positive effect on erythropoiesis. This research was published following the inclusion of this gas on the WADA Prohibited List in 2014 and had a high risk of bias. There were no studies available on the effect of argon inhalation on erythropoiesis. Furthermore, no studies were found on the effect of xenon or argon inhalation on steroidogenesis in healthy subjects and no studies relating to the effects of xenon or argon inhalation on erythropoiesis and steroidogenesis were found on the WADA website. Conclusion: There is still inconclusive evidence to support the administration of xenon and argon inhalations on erythropoiesis and steroidogenesis and their positive effects on health. Further research is warranted to establish the effects of these gases. Additionally, improved communication between anti-doping authorities and all key stakeholders is required to support the inclusion of various substances on recognized prohibited lists.

Ultrashort pulse X-ray free electron lasers (XFFLs) provided us with an unprecedented regime of X-ray intensities, revolutionizing ultrafast structure determination and paving the way to the novel field of non-linear X-ray optics. While pioneering studies revealed the formation of a nanoplasma following the interaction of an XFEL pulse with nanometer-scale matter, nanoplasma formation and disintegration processes are not completely understood, and the behavior of trapped electrons in the electrostatic potential of highly charged species is yet to be decrypted. Here we report the behavior of the nanoplasma created by a hard X-ray pulse interacting with xenon clusters by using electron and ion spectroscopy. To obtain a deep insight into the formation and disintegration of XFEL-ignited nanoplasma, we studied the XFEL-intensity and cluster-size dependencies of the ionization dynamics. We also present the time-resolved data obtained by a near-infrared (NIR) probe pulse in order to experimentally track the time evolution of plasma electrons distributed in the XFEL-ignited nanoplasma. We observed an unexpected time delay dependence of the ion yield enhancement due to the NIR pulse heating, which demonstrates that the plasma electrons within the XFEL-ignited nanoplasma are inhomogeneously distributed in space. [ABSTRACT FROM AUTHOR]

Background: The purpose of this study was to look at the long-term effects of retinal phototoxicity after macular hole repair surgery using xenon endolight illumination and Brilliant blue G (BBG) dye. Case presentation: An elderly man in his late seventies underwent para plana vitrectomy with BBG dye to repair an idiopathic full-thickness macular hole (MH) in his right eye. Prior to macular hole surgery, his visual acuity in the right eye was 6/60, N24 at the time of presentation. The MH closed with type 1 closure immediately after surgery, but there was extensive damage to the outer retinal layers and retinal pigment epithelium (RPE) at the macula, resulting in a reduction in visual acuity to 2/60. We presumed that the combination of BBG and xenon light, is the probable reason of retinotoxicity in the current patient. There was a progressive increase in the area of retinal and RPE layer damage and choroidal thinning over a 4-year period. Conclusion: Due to combined BBG-induced dye and endoilluminator toxicity, a rare case of continuously progressing RPE layer damage with choroidal thinning over a long follow-up interval was described. Such long-term effects of BBG and endolight induced retinotoxicity have not been reported in the literature, to the best of our knowledge. [ABSTRACT FROM AUTHOR]

G protein-coupled receptors can adopt many different conformational states, each of them exhibiting different restraints towards downstream signaling pathways. One promising strategy to identify and quantify this conformational landscape is to introduce a cysteine at a receptor site sensitive to different states and label this cysteine with a probe for detection. Here, the application of NMR of hyperpolarized 129Xe for the detection of the conformational states of human neuropeptide Y2 receptor is introduced. The xenon trapping cage molecule cryptophane-A attached to a cysteine in extracellular loop 2 of the receptor facilitates chemical exchange saturation transfer experiments without and in the presence of native ligand neuropeptide Y. High-quality spectra indicative of structural states of the receptor–cage conjugate were obtained. Specifically, five signals could be assigned to the conjugate in the apo form. After the addition of NPY, one additional signal and subtle modifications in the persisting signals could be detected. The correlation of the spectroscopic signals and structural states was achieved with molecular dynamics simulations, suggesting frequent contact between the xenon trapping cage and the receptor surface but a preferred interaction with the bound ligand. [ABSTRACT FROM AUTHOR]

Many processed EEG monitors (pEEG) are unreliable when non-GABAergic anesthetic agents are used. The primary aim of the study was to compare the response of the Bispectral Index (BIS) during emergence from anesthesia maintained by xenon and sevoflurane. To better understand the variation in response of pEEG to these agents, we also compared several EEG derived parameters relevant to pEEG monitoring during emergence. Twenty-four participants scheduled for lithotripsy were randomized to receive xenon or sevoflurane anesthesia. Participants were monitored with the BIS and had simultaneous raw EEG collected. BIS index values were compared at three key emergence timepoints: first response, eyes open and removal of airway. Two sets of EEG derived parameters, three related to the BIS: relative beta ratio, SynchFastSlow and SynchFastSlow biocoherence, and two unrelated to the BIS: spectral edge frequency and the composite cortical state, were calculated for comparison. BIS index values were significantly lower in the xenon group than the sevoflurane group at each emergence timepoint. The relative beta ratio parameter increased significantly during emergence in the sevoflurane group but not in the xenon group. The spectral edge frequency and composite cortical state parameters increased significantly in both groups during emergence. The BIS index is lower at equivalent stages of behavioural response during emergence from xenon anesthesia when compared to sevoflurane anesthesia, most likely due to differences in how these two agents influence the relative beta ratio. The spectral edge frequency and composite cortical state might better reflect emergence from xenon anaesthesia. Clinical trial number and registry Australia New Zealand Clinical Trials Registry Number: ACTRN12618000916246. [ABSTRACT FROM AUTHOR]

Xenon/krypton (Xe/Kr) separation is an important task in industry, yet it remains challenging to develop adsorbents with high Xe/Kr selectivity and adsorption capacity of Xe, especially at low partial pressures. Herein, we report a series of microporous carbon molecular sieves (CMSs) for Xe/Kr separation. Those materials have ideal bimodal pore size distributions that not only provide substantial space for the accommodation of gas molecules, but also allow selective diffusion of gas molecules. Additionally, the carbon frameworks decorated with polar oxygen-containing functional groups afford higher affinity for Xe than Kr, which is proven by density functional theory (DFT) calculations and charge density difference analysis. The optimal C-PVDC-700 exhibits a high selectivity of Xe/Kr and, more importantly, a record-high uptake of Xe (2.93 mmol g−1) at 0.2 bar and 298 K, which is the highest among all the reported carbon adsorbents. Breakthrough experiments confirm the excellent performance of such CMSs for Xe/Kr separation, and the dynamic adsorption uptake of Xe and productivity of high-purity Kr are calculated to be 2.91 mmol g−1 and 208 mL g−1 (9.29 mmol g−1), respectively, which also set up a new benchmark for Xe/Kr separation of carbon adsorbents. [ABSTRACT FROM AUTHOR]

High-throughput transparent and flexible electronics are essential technologies for next-generation displays, semiconductors, and wearable bio-medical applications. However, to manufacture a high-quality transparent and flexible electrode, conventional annealing processes generally require 5 min or more at a high temperature condition of 300 °C or higher. This high thermal budget condition is not only difficult to apply to general polymer-based flexible substrates, but also results in low-throughput. Here, we report a high-quality transparent electrode produced with an extremely low thermal budget using Xe-flash lamp rapid photonic curing. Photonic curing is an extremely short time (~ μs) process, making it possible to induce an annealing effect of over 800 °C. The photonic curing effect was optimized by selecting the appropriate power density, the irradiation energy of the Xe-flash lamp, and Ag layer thickness. Rapid photonic curing produced an ITO–Ag–ITO electrode with a low sheet resistance of 6.5 ohm/sq, with a high luminous transmittance of 92.34%. The low thermal budget characteristics of the rapid photonic curing technology make it suitable for high-quality transparent electronics and high-throughput processes such as roll-to-roll. [ABSTRACT FROM AUTHOR]

It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer's disease (AD), while the gaseous anaesthetic xenon (Xe) exhibits many features of a putative neuroprotective agent. Loss of synapses is regarded as one key cause of dementia in AD. Multiple EGF-like domains 10 (MEGF10) is one of the phagocytic receptors which assists the elimination of synapses by astrocytes. Here, we investigated how β-amyloid peptide 1–42 (Aβ1–42), Iso and Xe interact with MEGF10-dependent synapse elimination. Murine cultured astrocytes as well as cortical and hippocampal ex vivo brain slices were treated with either Aβ1–42, Iso or Xe and the combination of Aβ1–42 with either Iso or Xe. We quantified MEGF10 expression in astrocytes and dendritic spine density (DSD) in slices. In brain slices of wild type and AAV-induced MEGF10 knock-down mice, antibodies against astrocytes (GFAP), pre- (synaptophysin) and postsynaptic (PSD95) components were used for co-localization analyses by means of immunofluorescence-imaging and 3D rendering techniques. Aβ1–42 elevated pre- and postsynaptic components inside astrocytes and decreased DSD. The combined application with either Iso or Xe reversed these effects. In the presence of Aβ1–42 both anaesthetics decreased MEGF10 expression. AAV-induced knock-down of MEGF10 reduced the pre- and postsynaptic marker inside astrocytes. The presented data suggest Iso and Xe are able to reverse the Aβ1–42-induced enhancement of synaptic elimination in ex vivo hippocampal brain slices, presumably through MEGF10 downregulation. [ABSTRACT FROM AUTHOR]

The N 4,5 OO Auger electron spectrum in the kinetic energy region (14–37) eV has been measured with high resolution at electron incident energies between 71 eV and 2019 eV. The Auger and satellite lines are assigned by comparison with previous literature data. Several states which correspond to the resonant Auger transitions from the 4d 3/2, 5/2 6p states are observed. The PCI effects on the N 5 -O 2,3 O 2,3 (1S 0) Auger peak when the incident electron energy approaches to the N 5 edge (67.55 eV) is investigated and it is found that the dependence of the energy shift on the excess energy, E exc , is well represented by the function E exc β with β = (-1.40 ± 0.05). The "N 3 " N 4,5 O 2,3 Coster-Kronig spectrum is measured at various electron incident energies. The assignments of the features are made in comparison with a similar spectrum from synchrotron radiation measured by Kivimäki et al. [J. Electron Spectrosc. Relat. Phenom. 1999, 101 – 103 , 43–47]. The Auger spectrum in the kinetic energy regions (68–78) eV and (90–138) eV is observed for the first time in an electron impact experiment and a comparison is made with the photoionization experiment by Hikosaka et al. [Phys. Rev. A 2007, 76 , 032708]. [ABSTRACT FROM AUTHOR]

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Copyright of Academic Journal of Agriculture / Akademik Ziraat Dergisi is the property of University of Ordu, Faculty of Agriculture, Academic Journal of Agriculture and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The inert gas xenon (Xe) is increasingly used in medicine as a universal anesthetic, a regulator of cellular metabolism, and a broad-spectrum organoprotector. Commonly utilized Xe inhalation requires expensive equipment that is not universally available. Here we describe the production process and physical characteristics of a solid, highly stable xenon carrier based on α-cyclodextrin (α-CD), developed for oral administration. It was found, that the interaction of α-CD with Xe in an aqueous solution and elevated pressure leads to precipitation of the α-CD-Xe complex. We have discovered three new properties of the resulting complex that promote long-term storage and oral delivery of Xe. (i) At temperatures below 0 °C, the precipitated α-CD-Xe complex containing water is so stable that it allows the removal of water by vacuum freeze-drying (lyophilization). (ii). Lyophilized α-CD-Xe remains stable for months at room temperature. (iii) Upon contact with water, α-CD-Xe rapidly releases gaseous Xe. As revealed in the forced swim test, after oral administration of lyophilized α-CD-Xe to rats, the duration of swimming was significantly increased. The obtained data open up prospects for the development of drugs based on the lyophilized α-CD-Xe complex suitable for storage, transportation, and medical use, including outside the hospital. [Display omitted] • A method of lyophilization of cyclodextrin complex with xenon has been developed. • The lyophilized complex can be stored for many months in the absence of moisture. • Upon contact with water or body fluids, xenon is rapidly released. • Oral administration of the drug to rats increases muscle endurance. [ABSTRACT FROM AUTHOR]

In order to solve the problem of organic mineral processing agent pollution, photoactivated persulfate system was used to degrade ester-105. The effects of light intensity, potassium persulfate concentration, pH value, common cationic ions and other factors on ester-105 degradation were investigated, and the system was simulated by kinetic model. The results showed that the degradation of ester-105 by photoactivated persulfate followed the zero-order kinetics. Under different illumination conditions, the degradation rate of mercury lamp is high but the reaction is too fast, so xenon lamps are used to simulate sunlight exposure better. In a certain range, increasing xenon lamp power and potassium persulfate concentration can promote degradation, and the reaction rate constant increases. The strong acidity of the solution is conducive to degradation, while alkalinity inhibits degradation. A certain concentration of anions such as Cl-, NO3- and HCO3- can promote the degradation of pollutants, and Fe2+ has a significant promoting effect. The quenching agent is added to capture the free radicals, so that • OH and SO4- play the oxidation role together. [ABSTRACT FROM AUTHOR]

Maintaining the electric fields necessary for the current generation of noble liquid time projection chambers (TPCs), with drift lengths exceeding 1 m, requires a large negative voltage applied to their cathode. Delivering such high voltage is associated with an elevated risk of electrostatic discharge and electroluminescence, which would be detrimental to the performance of the experiment. The Xenon Breakdown Apparatus (XeBrA) is a 5-l, high voltage test chamber built to investigate the contributing factors to electrical breakdown in noble liquids. In this work, we present the main findings after conducting scans over stressed electrode areas, surface finish, pressure, and high voltage ramp speed in the medium of liquid xenon. Area scaling and surface finish were observed to be the dominant factors affecting breakdown, whereas no significant changes were observed with varying pressure or ramp speed. A general rise in both the anode current and photon rate was observed in the last 30 s, leading up to a breakdown, with a marked increase in the last couple of seconds. In addition, the position of breakdowns was reconstructed with a system of high-speed cameras and a moderate correlation with the Fowler–Nordheim field emission model was found. Tentative evidence for bubble nucleation being the originating mechanism of breakdown in the liquid was also observed. We deem the results presented in this work to be of particular interest for the design of future, large TPCs, and practical recommendations are provided. [ABSTRACT FROM AUTHOR]

The continuous emanation of 222 Rn from detector surfaces causes the dominant background in current liquid xenon time projection chambers (TPCs) searching for dark matter. A significant reduction is required for the next generation of detectors which are aiming to reach the neutrino floor, such as DARWIN. 222 Rn -induced backgrounds can be reduced using a hermetic TPC, in which the sensitive target volume is mechanically separated from the rest of the detector containing the majority of Rn-emanating surfaces. We present a hermetic TPC that mainly follows the well-established design of leading xenon TPCs and has been operated successfully over a period of several weeks. By scaling up the results achieved to the DARWIN-scale, we show that the hermetic TPC concept can reduce the 222 Rn concentration to the required level, even with imperfect separation of the volumes. [ABSTRACT FROM AUTHOR]

Molten salt reactor operation will necessitate circulation of a cover gas to remove certain evolved fission products and maintain an inert atmosphere. The cover gas leaving the reactor core is expected to contain both noble and non-noble gases, aerosols, volatile species, tritium, and radionuclides and their daughters. To remove these radioactive gases, it is necessary to develop a robust off-gas system, along with novel sensors to monitor the gas stream and the treatment system performance. In this study, a metal organic framework (MOF) was engineered for the capture of Xe, a major contributor to the off-gas source term. The engineered MOF column was tested with a laser-induced breakdown spectroscopy (LIBS) sensor for noble gas monitoring. The LIBS sensor was used to monitor breakthrough tests with various Xe, Kr, and Ar mixtures to determine the Xe selectivity of the MOF column. This study offers an initial demonstration of the feasibility of monitoring off-gas treatment systems using a LIBS sensor to aid in the development of new capture systems for molten salt reactors. [ABSTRACT FROM AUTHOR]

The reaction between H3OSbF6, XeF5SbF6, and M(SbF6)2 (M=Ca, Cd) in anhydrous HF gave (H3O)(XeF5)2M2(SbF6)7 ⋅ nHF salts (n=3.95 for M=Ca and n=3.21 for M=Cd) upon crystallization. Their crystal structures consist of SbF6 units connecting M2+ centers located in the same plane. In this way, slabs are formed, each slab containing a layer of M2+ cations. The [XeF5]+ and [H3O]+ cations are located between adjacent slabs. Single crystals of (O2)(XeF5)2Sr4(SbF6)11 ⋅ 8HF were grown from aHF solution prepared by reaction between O2SbF6, XeF2, SrF2, SbF3 and UV‐irradiated F2. Attempts to grow single crystals of the fluoridoantimonate(V) salt containing simultaneously the cation [H3O]+ and XeF2 coordinated to an M2+ metal center failed. Instead, only a few single crystals of the H3O[Sr(HF)2]3(SbF6)6(Sb2F11) salt were observed. An attempt to grow single crystals of NH4XeF5MnF6 from aHF solution yielded only a mixture of (XeF5)2MnF6 and (NH4)2MnF6. [ABSTRACT FROM AUTHOR]

In recent years, the use of xenon as a modern inhalation anesthetic has become more and more attractive because of its minimal side effects and its intra-/postoperative neuro-, cardio-, and renoprotective properties. Recent studies have demonstrated that this is due to the inhibition of norepinephrine reuptake, an increase in the production of a specific regulatory protein, hypoxia-inducible factor 1α (HIF-1α) and, therefore, the secretion of the hormone erythropoietin. Given the pharmacological properties of this gas, there is a probability of its use by some athletes to gain competitive advantage. Therefore, the purpose of this article was to study the fundamental possibility of the direct, simple, and specific determination of xenon in the equilibrium vapor phase of whole blood samples from healthy volunteers (n = 10) by a GC-MS/MS triple quadrupole system in the selective reaction monitoring (pseudo-SRM) mode m/z 129 → 129, 131 → 131, 132 → 132 after five-day gas inhalation procedures with a xenon-oxygen mixture 25 : 75 (v/v). Three characteristic isotopes with the highest intensity were selected for the determination, which made it possible to unambiguously detect an inert gas by the above-mentioned method. This approach can be used to detect the inert gas from WADA Prohibited List in whole blood samples collected under the Athlete Biological Passport (ABP) program. [ABSTRACT FROM AUTHOR]

After emergency protection activation, a boric acid solution is immediately introduced into the VVER-1200 reactor core until the concentration of the acid reaches the shutdown value. Then the control rods are raised after which the permission to start up the reactor is obtained. After reaching the minimum controlled level, first, makeup with a high flow rate of pure condensate is carried out to the starting range; the first circuit is mixed; and then pure condensate is added at a low flow rate. However, the technical regulations for safe operation specify that the pure condensate flow rate in the starting range should not exceed the value set for the compensation for xenon poisoning by more than 10 t/h, and the positive reactivity insertion rate should not exceed 0.02 βeff/min. It is not entirely clear how the pure condensate flow rate can be estimated, since the power unit is not equipped with instruments that measure the level of xenon poisoning and the reactivity insertion rate. The pure condensate flow rate that the operator can use in the starting range in the presence of xenon processes is determined. [ABSTRACT FROM AUTHOR]

Although critical for development of novel therapies, understanding altered lung function in disease models is challenging because the transport and diffusion of gases over short distances, on which proper function relies, is not readily visualized. In this review we summarize progress introducing hyperpolarized 129Xe imaging as a method to follow these processes in vivo. The work is organized in sections highlighting methods to observe the gas replacement effects of breathing (Gas Dynamics during the Breathing Cycle) and gas diffusion throughout the parenchymal airspaces (3). We then describe the spectral signatures indicative of gas dissolution and uptake (4), and how these features can be used to follow the gas as it enters the tissue and capillary bed, is taken up by hemoglobin in the red blood cells (5), re-enters the gas phase prior to exhalation (6), or is carried via the vasculature to other organs and body structures (7). We conclude with a discussion of practical imaging and spectroscopy techniques that deliver quantifiable metrics despite the small size, rapid motion and decay of signal and coherence characteristic of the magnetically inhomogeneous lung in preclinical models (8). [ABSTRACT FROM AUTHOR]