Search

With the rise of the sharing economy, shared bicycles have become an important component of urban transportation. This paper explores the nonlinear dual oligopoly system for the Cournot model in the bike-sharing market; both operators have maximized profits as their competitive goals. The analysis of pivotal factors influencing passenger preferences, including pricing discounts and comfort levels, is meticulously depicted by a bifurcation diagram. A new chaotic attractor—the shared bicycle attractor—is discovered. The research results indicate that larger discounts and adjustment speeds can cause the system to be in a chaotic state, which is not conducive to the long-term development of operators, although discounts can indeed attract more passengers to a certain extent. On the other hand, the increase in the marginal cost of comfort loss can also make it difficult for enterprises to operate, which requires continuous technological innovation to improve the comfort of cycling. [ABSTRACT FROM AUTHOR]

Nowadays, engine room simulators have become an important tool for maritime training, but programming engine room simulators often involves handling large amounts of data, making the process inefficient. This paper proposes an innovative visual modeling method for the ship pipeline network program in engine room simulators, aimed at addressing the heavy programming tasks associated with traditional text-based design and calculation methods when dealing with complex and large-scale pipeline systems. By creating Scalable Vector Graphics (SVG) images and using Windows Presentation Foundation (WPF) to place controls, an intuitive graphical user interface is built, allowing programmers to easily operate through the graphical interface. Subsequently, You Only Look Once version 5 (YOLOv5) object detection technology is used to identify the completed SVG images and WPF controls, generating corresponding Comma-Separated Values (CSV) files, which are then used as data input via C# (C Sharp). Through automated data processing and equipment recognition, compared to traditional manual design processes (such as using Matlab or C++ for pipeline design), this method reduces human errors and improves programming accuracy. Customization of key pipeline characteristics (such as maximum flow and flow direction) enhances the accuracy and applicability of the pipeline network model. The intuitive user interface design also allows nonprofessional users to easily design and optimize pipeline systems. The results show that this tool not only improves the efficiency of data processing and calculation but also demonstrates excellent performance and broad application prospects in the design and optimization of ship pipeline systems. In the future, this tool is expected to be more widely promoted in ship pipeline network education and practical applications, driving the field towards more efficient and intelligent development. [ABSTRACT FROM AUTHOR]

Aims: A recent guideline presented by the ESC Congress in 2022 had indicated a novel therapy targeted at pulmonary artery hypertension, known as pulmonary artery denervation (PADN), which get inspired from a laboratorial trial that could lowering the pulmonary artery pressure through the intervention on the animals. Our aim is to conduct a network meta‐analysis to compare the efficacy and safety of PADN from six aspects with the current conventional therapies. Methods and results: According to the PRISMA guidance, databases including Ovid, ClinicalTrials.gov, Medline, Embase, and PubMed were searched from inception to 22 August 2023, along with a full assessment of the previous five meta‐analyses. Data were extracted and curated for Bayesian network meta‐analysis. The primary outcome was the change in the 6‐min walking distance (6MWD) from baseline with a secondary outcome called change in mean pulmonary artery pressure (mPAP) from baseline. The four safety outcomes included risk of clinical worsening, hospitalization, mortality and severe adverse events (SAEs). The comparison is structured on a contrast model based on 65 randomized controlled trials (RCTs) on PADN and the other conventional mainstream drugs. PADN had a better effect in improving 6MWD than Placebo (−77.76 m, 95% CI: −102.04 to −54.34 m), Macitentan (−65.32 m, 95% CI: −95.34 to −36.1 m), Bosentan (−64.5 m, 95% CI: −94.7 to −35.07 m), Iloprost (−62.66 m, 95% CI: −99.48 to −27.13 m), Oxygen (−62.42 m, 95% CI: −100.01 to −25.78 m), Treprostinil (−62.01 m, 95% CI: −89.04 to −35.61 m), Riociguat (−60.59 m, 95% CI: −86.11 to −35.98 m), Selexipag (−47.2 m, 95% CI: −85.61 to −10.19 m), Sildenafil (−44.92 m, 95% CI: −74.43 to −16.15 m), or Sitaxsentan (−39.53 m, 95% CI: −78.99 to −0.76 m). PADN had a better antihypertensive effect than placebo and showed statistical significant lower risks to induce clinical worsening and re‐hospitalization than treprostinil, riociguat, and placebo groups. No statistically significant difference in risk of mortality and severe adverse events was observed between PADN versus the other interventions. Conclusions: Compared with 16 types of conventional therapies and Placebo, PADN has advantage over nine single therapies and Placebo in improving 6MWD and appears to be better than two types of dual‐drug combined therapies while with no statistical significance. PADN shows a favourable antihypertensive effect on mPAP and has a lower risk to trigger clinical worsening or hospitalization, while its risk on mortality and severe adverse events is still inconclusive. [ABSTRACT FROM AUTHOR]

Human exposure to various N,N′-substituted p-phenylenediamine-derived quinones (PPDQs) has been of increasing concern. Recent studies have examined N-phenyl-N′-(1,3-dimethylbutyl)-p-phenylenediamine-derived quinone (6PPDQ) in human urine to evaluate human exposure. However, other PPDQs in human urine have not been thoroughly investigated. This study analyzed six PPDQs in urine collected from 149 healthy individuals in Taizhou, China. All target PPDQs were detected, with 6PPDQ (mean 2.4 ng/mL,