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1,670 results on '"Wittert, Gary a."'

202. Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 ( mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice

Author

Tangseefa, Pawanrat, primary, Martin, Sally K., additional, Arthur, Agnieszka, additional, Panagopoulos, Vasilios, additional, Page, Amanda J., additional, Wittert, Gary A., additional, Proud, Christopher G., additional, Fitter, Stephen, additional, and Zannettino, Andrew C.W., additional

Published
2021
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203. Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT

Author

Ng Tang Fui, Mark, primary, Hoermann, Rudolf, additional, Bracken, Karen, additional, Handelsman, David J, additional, Inder, Warrick J, additional, Stuckey, Bronwyn G A, additional, Yeap, Bu B, additional, Ghasem-Zadeh, Ali, additional, Robledo, Kristy P, additional, Jesudason, David, additional, Zajac, Jeffrey D, additional, Wittert, Gary A, additional, and Grossmann, Mathis, additional

Published
2021
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204. Usability, Acceptability, and Safety Analysis of a Computer-Tailored Web-Based Exercise Intervention (ExerciseGuide) for Individuals With Metastatic Prostate Cancer: Multi-Methods Laboratory-Based Study (Preprint)

Author

Evans, Holly EL, primary, Forbes, Cynthia C, additional, Galvão, Daniel A, additional, Vandelanotte, Corneel, additional, Newton, Robert U, additional, Wittert, Gary, additional, Chambers, Suzanne, additional, Vincent, Andrew D, additional, Kichenadasse, Ganessan, additional, Girard, Danielle, additional, Brook, Nicholas, additional, and Short, Camille E, additional

Published
2021
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211. Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer

Author

Miladinovic, Dushan, Cusick, Thomas, Mahon, Kate, Haynes, Anne, Cortie, Colin H, Meyer, Barbara J, Stricker, Phillip, Wittert, Gary, Butler, Lisa, Horvath, Lisa, Hoy, Andrew, Miladinovic, Dushan, Cusick, Thomas, Mahon, Kate, Haynes, Anne, Cortie, Colin H, Meyer, Barbara J, Stricker, Phillip, Wittert, Gary, Butler, Lisa, Horvath, Lisa, and Hoy, Andrew

Abstract

The prostate is surrounded by periprostatic adipose tissue (PPAT), the thickness of which has been associated with more aggressive prostate cancer (PCa). There are limited data regarding the functional characteristics of PPAT, how it compares to subcutaneous adipose tissue (SAT), and whether in a setting of localized PCa, these traits are altered by obesity or disease aggressiveness. PPAT and SAT were collected from 60 men (age: 42-78 years, BMI: 21.3-35.6 kg/m2) undergoing total prostatectomy for PCa. Compared to SAT, adipocytes in PPAT were smaller, had the same basal rates of fatty acid release (lipolysis) yet released less polyunsaturated fatty acid species, and were more sensitive to isoproterenol-stimulated lipolysis. Basal lipolysis of PPAT was increased in men diagnosed with less aggressive PCa (Gleason score (GS) ≤ 3 + 4) compared to men with more aggressive PCa (GS ≥ 4 + 3) but no other measured adipocyte parameters related to PCa aggressiveness. Likewise, there was no difference in PPAT lipid biology between lean and obese men. In conclusion, lipid biological features of PPAT do differ from SAT; however, we did not observe any meaningful difference in ex vivo PPAT biology that is associated with PCa aggressiveness or obesity. As such, our findings do not support a relationship between altered PCa behavior in obese men and the metabolic reprogramming of PPAT.

Published
2020

218. The impact of a meal, snack, or not eating during the night shift on simulated driving performance post-shift

Author

Gupta, Charlotte C, primary, Centofanti, Stephanie, additional, Dorrian, Jillian, additional, Coates, Alison M, additional, Stepien, Jacqueline M, additional, Kennaway, David, additional, Wittert, Gary, additional, Heilbronn, Leonie, additional, Catcheside, Peter, additional, Tuckwell, Georgia A, additional, Coro, Daniel, additional, Chandrakumar, Dilushi, additional, and Banks, Siobhan, additional

Published
2020
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220. Obesity

Author

Khoo, Joan, primary, Chen, Richard Y. T., additional, and Wittert, Gary A., additional

Published
2012
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221. Leptin prevents obesity induced by a high-fat diet after diet-induced weight loss in the marsupial S. crassicaudata

Author

Wittert, Gary A., Turnbull, Helen, Hope, Perdita, Morley, John E., and Horowitz, Michael

Subjects
Obesity -- Research, Leptin -- Research, Biological sciences
Abstract

Wittert, Gary A., Helen Turnbull, Perdita Hope, John E. Morley, and Michael Horowitz. Leptin prevents obesity induced by a high-fat diet after diet-induced weight loss in the marsupial S. crassicaudata. Am J Physiol Regul Integr Comp Physiol 286: R734-R739, 2004; 10.1152/ajpregu.00240.2003.--The aims of this study were to determine in the marsupial Sminthopsis crassicaudata, the effects of leptin on food intake, body weight, tail width (a reflection of fat stores), and leptin mRNA, after caloric restriction followed by refeeding ad libitum with either a standard or high-fat preferred diet. S. crassicaudata (n = 32), were fed standard laboratory diet (LabD; 1.01 kcal/g, 20% fat) ad libitum for 3 days. On days 4-10, animals received LabD at 75% of basal intake and then (days 11-25) were fed either LabD or a choice of LabD and mealworms (MW; 2.99 kcal/g, 30% fat); during this time, half the animals (n = 8) in each group received either leptin (2.5 mg/kg) or PBS intraperitoneally two times daily. On day 26, animals were killed and fat was removed for assay of leptin mRNA. At baseline, body weight, tail width, and food intake were similar in each group. After caloric restriction, body weight (P < 0.001) and tail width (P < 0.001) decreased. On return to ad libitum feeding in the PBS-treated animals, body weight and tail width returned to baseline in the LabD-fed animals (P < 0.001) and increased above baseline in the MW-fed animals (P < 0.001). In the LabD groups, tail width (P < 0.001) and body weight (P < 0.001) decreased after leptin compared with PBS. In the MW groups, the increase in tail width (P < 0.001) and body weight (P = 0.001) were attenuated after leptin compared with PBS. The expression of leptin mRNA in groups fed MW were greater in PBS than in leptin-treated animals (P < 0.05). Therefore, after diet-induced weight loss, leptin prevents a gain in fat mass in S. crassicaudata; this has potential implications for the therapeutic use of leptin. adipose tissue; resistance; Sminthopsis crassicaudata

Published
2004

233. Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status

Author

Wittert, Gary A., Chapman, Ian M., Haren, Matthew T., Mackintosh, Shylie, Coates, Penelope, and Morley, John E.

Subjects
Testosterone -- Physiological aspects, Aged men -- Physiological aspects, Health, Seniors
Abstract

Background. Loss of muscle mass (sarcopenia) leads to frailty in older men. The decline in testosterone over the life span may contribute to this muscle loss. We studied the ability of oral testosterone to prevent muscle loss in older men over a 12-month period. Methods. A standard dose (80 mg twice daily) of testosterone undecanoate or placebo was administered for 1 year to 76 healthy men aged 60 years or older. All men had a free testosterone index of 0.3-0.5, which represents a value below the normal lower limit for young men (19-30 years), but remains within the overall normal male range. Measurements of body composition, muscle strength, hormones, and safety parameters were obtained at 0, 6, and 12 months. Results. Lean body mass increased (p = .0001) and fat mass decreased (p = .02) in the testosterone as compared with the placebo-treated group. There were no significant effects on muscle strength. There was a significant increase in hematocrit (0.02%) in the testosterone-treated group (p = .03). Plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels were similar in both groups, but there was a decrease in high-density lipoprotein cholesterol (-0.1 mmol/L) at 12 months in the testosterone group as compared to the placebo group (p = 0.026). There were no differences in prostate-specific antigen or systolic or diastolic blood pressure between the groups. Conclusion. Oral testosterone administration to older relatively hypogonadal men results in an increase in muscle mass and a decrease in body fat.

Published
2003

244. Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial

Author

Evans, Holly EL, primary, Forbes, Cynthia C, additional, Galvão, Daniel A, additional, Vandelanotte, Corneel, additional, Newton, Robert U, additional, Wittert, Gary, additional, Chambers, Suzanne, additional, Vincent, Andrew D, additional, Kichenadasse, Ganessan, additional, Brook, Nicholas, additional, Girard, Danielle, additional, and Short, Camille E, additional

Published
2020
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245. Serum Testosterone is Inversely and Sex Hormone-binding Globulin is Directly Associated with All-cause Mortality in Men

Author

Yeap, Bu B, primary, Marriott, Ross J, additional, Antonio, Leen, additional, Chan, Yi X, additional, Raj, Suchitra, additional, Dwivedi, Girish, additional, Reid, Christopher M, additional, Anawalt, Bradley D, additional, Bhasin, Shalender, additional, Dobs, Adrian S, additional, Hankey, Graeme J, additional, Matsumoto, Alvin M, additional, Norman, Paul E, additional, O’Neill, Terence W, additional, Ohlsson, Claes, additional, Orwoll, Eric S, additional, Vanderschueren, Dirk, additional, Wittert, Gary A, additional, Wu, Frederick C W, additional, and Murray, Kevin, additional

Published
2020
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246. Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone–binding globulin in men from UK Biobank

Author

Yeap, Bu B., primary, Marriott, Ross J., additional, Antonio, Leen, additional, Bhasin, Shalender, additional, Dobs, Adrian S., additional, Dwivedi, Girish, additional, Flicker, Leon, additional, Matsumoto, Alvin M., additional, Ohlsson, Claes, additional, Orwoll, Eric S., additional, Raj, Suchitra, additional, Reid, Christopher M., additional, Vanderschueren, Dirk, additional, Wittert, Gary A., additional, Wu, Frederick C. W., additional, and Murray, Kevin, additional

Published
2020
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248. Men’s sexual help-seeking and care needs after radical prostatectomy or other non-hormonal, active prostate cancer treatments

Author

Hyde, Melissa K., primary, Opozda, Melissa, additional, Laurie, Kirstyn, additional, Vincent, Andrew D., additional, Oliffe, John L., additional, Nelson, Christian J., additional, Dunn, Jeff, additional, Chung, Eric, additional, Gillman, Michael, additional, Manecksha, Rustom P., additional, Wittert, Gary, additional, and Chambers, Suzanne K., additional

Published
2020
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249. Examining the Priorities, Needs and Preferences of Men with Metastatic Prostate Cancer in Designing a Personalised eHealth Exercise Intervention

Author

Evans, Holly E. L., primary, Forbes, Cynthia C., additional, Vandelanotte, Corneel, additional, Galvão, Daniel A., additional, Newton, Robert U., additional, Wittert, Gary, additional, Chambers, Suzanne, additional, Kichenadasse, Ganessan, additional, Brook, Nicholas, additional, Girard, Danielle, additional, and Short, Camille E., additional

Published
2020
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