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1,734 results on '"Wesseling, Pieter"'

201. IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO

Author

Reuss, David E., Mamatjan, Yasin, Schrimpf, Daniel, Capper, David, Hovestadt, Volker, Kratz, Annekathrin, Sahm, Felix, Koelsche, Christian, Korshunov, Andrey, Olar, Adriana, Hartmann, Christian, Reijneveld, Jaap C., Wesseling, Pieter, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Herold-Mende, Christel, Aldape, Kenneth, and von Deimling, Andreas

Published
2015
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204. Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial

Author

Tesileanu, C. Mircea S., primary, Sanson, Marc, additional, Wick, Wolfgang, additional, Brandes, Alba A., additional, Clement, Paul M., additional, Erridge, Sara C., additional, Vogelbaum, Michael A., additional, Nowak, Anna K., additional, Baurain, Jean-Francois, additional, Mason, Warren P., additional, Wheeler, Helen, additional, Chinot, Olivier L., additional, Gill, Sanjeev, additional, Griffin, Matthew, additional, Rogers, Leland, additional, Taal, Walter, additional, Rudà, Roberta, additional, Weller, Michael, additional, McBain, Catherine, additional, van Linde, Myra E., additional, Aldape, Kenneth, additional, Jenkins, Robert B., additional, Kros, Johan M., additional, Wesseling, Pieter, additional, von Deimling, Andreas, additional, Hoogstrate, Youri, additional, de Heer, Iris, additional, Atmodimedjo, Peggy N., additional, Dubbink, Hendrikus J., additional, Brouwer, Rutger W.W., additional, van IJcken, Wilfred F.J., additional, Cheung, Kin Jip, additional, Golfinopoulos, Vassilis, additional, Baumert, Brigitta G., additional, Gorlia, Thierry, additional, French, Pim J., additional, and van den Bent, Martin J., additional

Published
2022
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206. Erratum:Rapid early progression (REP) of glioblastoma is an independent negative prognostic factor: Results from a systematic review and meta-analysis (Neuro-Oncology Advances (2022) 4:1 (vdac075) DOI: 10.1093/noajnl/vdac075)

Author

Waqar, Mueez, Roncaroli, Federico, Lehrer, Eric J., Palmer, Joshua D., Villanueva-Meyer, Javier, Braunstein, Steve, Hall, Emma, Aznar, Marianne, de Witt Hamer, Philip C., D'Urso, Pietro I., Trifiletti, Daniel, Quiñones-Hinojosa, Alfredo, Wesseling, Pieter, Borst, Gerben R., Neurosurgery, Amsterdam Neuroscience - Systems & Network Neuroscience, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Pathology, and AII - Cancer immunology

Abstract

This is an erratum to: Mueez Waqar, Federico Roncaroli, Eric J Lehrer, Joshua D Palmer, Javier Villanueva-Meyer, Steve Braunstein, Emma Hall, Marianne Aznar, Philip C De Witt Hamer, Pietro I D'Urso, Daniel Trifiletti, Alfredo Quiñones- Hinojosa, Pieter Wesseling, Gerben R Borst, Rapid early progression (REP) of glioblastoma is an independent negative prognostic factor: Results from a systematic review and meta-analysis, Neuro-Oncology Advances, Volume 4, Issue 1, January-December 2022, vdac075, https://doi.org/10.1093/ noajnl/vdac075 In the originally published version of this manuscript, the surname of author Gerben R Borst was inadvertently misspelled as Gerben R Bors. This error has been corrected.

Published
2022

209. Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis

Author

Tortajada, Salvador, Fuster-Garcia, Elies, Vicente, Javier, Wesseling, Pieter, Howe, Franklyn A., Julià-Sapé, Margarida, Candiota, Ana-Paula, Monleón, Daniel, Moreno-Torres, Àngel, Pujol, Jesús, Griffiths, John R., Wright, Alan, Peet, Andrew C., Martínez-Bisbal, M. Carmen, Celda, Bernardo, Arús, Carles, Robles, Montserrat, and García-Gómez, Juan Miguel

Published
2011
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210. Rare central nervous system tumors in adults: a population-based study of ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors

Author

Ho, Vincent K Y, primary, Gijtenbeek, Anja (J) M M, additional, Wagemakers, Michiel, additional, Taal, Walter, additional, van Linde, Myra E, additional, Swaak-Kragten, Annemarie T, additional, Kurt, Erkan, additional, van der Weide, Hiske L, additional, Wesseling, Pieter, additional, de Vos, Filip Y, additional, and Bromberg, Jacoline E C, additional

Published
2022
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211. Oligosarcomas, IDH-mutant are distinct and aggressive

Author

Suwala, Abigail K., primary, Felix, Marius, additional, Friedel, Dennis, additional, Stichel, Damian, additional, Schrimpf, Daniel, additional, Hinz, Felix, additional, Hewer, Ekkehard, additional, Schweizer, Leonille, additional, Dohmen, Hildegard, additional, Pohl, Ute, additional, Staszewski, Ori, additional, Korshunov, Andrey, additional, Stein, Marco, additional, Wongsurawat, Thidathip, additional, Cheunsuacchon, Pornsuk, additional, Sathornsumetee, Sith, additional, Koelsche, Christian, additional, Turner, Clinton, additional, Le Rhun, Emilie, additional, Mühlebner, Angelika, additional, Schucht, Philippe, additional, Özduman, Koray, additional, Ono, Takahiro, additional, Shimizu, Hiroaki, additional, Prinz, Marco, additional, Acker, Till, additional, Herold-Mende, Christel, additional, Kessler, Tobias, additional, Wick, Wolfgang, additional, Capper, David, additional, Wesseling, Pieter, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Hartmann, Christian, additional, and Reuss, David E., additional

Published
2021
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212. Relapsed Medulloblastoma in Pre-Irradiated Patients: Current Practice for Diagnostics and Treatment

Author

Hill, Rebecca M., primary, Plasschaert, Sabine L. A., additional, Timmermann, Beate, additional, Dufour, Christelle, additional, Aquilina, Kristian, additional, Avula, Shivaram, additional, Donovan, Laura, additional, Lequin, Maarten, additional, Pietsch, Torsten, additional, Thomale, Ulrich, additional, Tippelt, Stephan, additional, Wesseling, Pieter, additional, Rutkowski, Stefan, additional, Clifford, Steven C., additional, Pfister, Stefan M., additional, Bailey, Simon, additional, and Fleischhack, Gudrun, additional

Published
2021
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214. A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Author

Pfister, Stefan M., primary, Reyes-Múgica, Miguel, additional, Chan, John K.C., additional, Hasle, Henrik, additional, Lazar, Alexander J., additional, Rossi, Sabrina, additional, Ferrari, Andrea, additional, Jarzembowski, Jason A., additional, Pritchard-Jones, Kathy, additional, Hill, D. Ashley, additional, Jacques, Thomas S., additional, Wesseling, Pieter, additional, López Terrada, Dolores H., additional, von Deimling, Andreas, additional, Kratz, Christian P., additional, Cree, Ian A., additional, and Alaggio, Rita, additional

Published
2021
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216. EPCO-17. METHYLATION ANALYSIS OF MATCHED PRIMARY AND RECURRENT IDHmt ASTROCYTOMA; AN UPDATE FROM THE GLIOMA LONGITUDINAL ANALYSIS NL (GLASS-NL) CONSORTIUM

Author

Vallentgoed, Wies, primary, Niers, Anneke, additional, van Garderen, Karin, additional, van den Bent, Martin, additional, Draaisma, Kaspar, additional, de Heer, Iris, additional, Kouwenhoven, Mathilde, additional, Kros, Johan, additional, Martin, Ivonne, additional, Robe, Pierre, additional, Smits, Marion, additional, Tesileanu, Mircea, additional, van Thuijl, Hinke, additional, Verhaak, Roel, additional, Westerman, Bart, additional, van de Wiel, Mark, additional, Ylstra, Bauke, additional, de Leng, Wendy, additional, Wesseling, Pieter, additional, and French, Pim, additional

Published
2021
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217. PATH-23. OLIGOSARCOMA, IDH-MUTANT IS A DISTINCT AGGRESSIVE TYPE

Author

Suwala, Abigail K, primary, Felix, Marius, additional, Friedel, Dennis, additional, Stichel, Damian, additional, Schrimpf, Daniel, additional, Hewer, Ekkehard, additional, Schweizer, Leonille, additional, Dohmen, Hildegard, additional, Pohl, Ute, additional, Erny, Daniel, additional, Koelsche, Christian, additional, Turner, Clinton, additional, Özduman, Koray, additional, Prinz, Marco, additional, Acker, Till, additional, Herold-Mende, Christel, additional, Wick, Wolfgang, additional, Capper, David, additional, Wesseling, Pieter, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Hartmann, Christian, additional, and Reuss, David, additional

Published
2021
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218. EPCO-09. LONGITUDINAL ANALYSIS OF DIFFUSE GLIOMA REVEALS CELL STATE DYNAMICS AT RECURRENCE ASSOCIATED WITH CHANGES IN GENETICS AND THE MICROENVIRONMENT

Author

Varn, Frederick, primary, Johnson, Kevin, additional, Wade, Taylor, additional, Malta, Tathiane, additional, Sabedot, Thais, additional, Barthel, Floris, additional, Kim, Hoon, additional, Ahmed, Nazia, additional, Datta, Indrani, additional, Barnholtz-Sloan, Jill, additional, Bakas, Spyridon, additional, D'Angelo, Fulvio, additional, Gan, Hui, additional, Garofano, Luciano, additional, Huse, Jason, additional, Khasraw, Mustafa, additional, Kocakavuk, Emre, additional, Migliozzi, Simona, additional, Ormond, David, additional, Paek, Sun Ha, additional, Van Meir, Erwin, additional, Walenkamp, Annemiek, additional, Watts, Colin, additional, Weller, Michael, additional, Weiss, Tobias, additional, Wesseling, Pieter, additional, Stead, Lucy, additional, Poisson, Laila, additional, Noushmehr, Houtan, additional, Iavarone, Antonio, additional, and Verhaak, Roel, additional

Published
2021
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221. Human pontine glioma cells can induce murine tumors

Author

Caretti, Viola, Sewing, A. Charlotte P., Lagerweij, Tonny, Schellen, Pepijn, Bugiani, Marianna, Jansen, Marc H. A., van Vuurden, Dannis G., Navis, Anna C., Horsman, Ilona, Vandertop, W. Peter, Noske, David P., Wesseling, Pieter, Kaspers, Gertjan J. L., Nazarian, Javad, Vogel, Hannes, Hulleman, Esther, Monje, Michelle, and Wurdinger, Thomas

Published
2014
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223. Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

Author

Heim, Stephanie, Sill, Martin, Jones, David T.W., Vasiljevic, Alexandre, Jouvet, Anne, Fèvre-Montange, Michelle, Wesseling, Pieter, Beschorner, Rudi, Mittelbronn, Michel, Kohlhof, Patricia, Hovestadt, Volker, Johann, Pascal, Kool, Marcel, Pajtler, Kristian W., Korshunov, Andrey, Ruland, Vincent, Sperveslage, Jan, Thomas, Christian, Witt, Hendrik, von Deimling, Andreas, Paulus, Werner, Pfister, Stefan M., Capper, David, and Hasselblatt, Martin

Published
2016
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224. Longitudinal characteristics of T2-FLAIR mismatch in IDH-mutant astrocytomas: Relation to grade, histopathology, and overall survival in the GLASS-NL cohort.

Author

Garderen, Karin A van, Vallentgoed, Wies R, Lavrova, Anna, Niers, Johanna M, Leng, Wendy W J de, Hoogstrate, Youri, Heer, Iris de, Ylstra, Bauke, Dijk, Erik van, Klein, Stefan, Draaisma, Kaspar, Robe, Pierre A J T, Verhaak, Roel G W, Westerman, Bart A, French, Pim J, Bent, Martin J van den, Kouwenhoven, Mathilde C M, Kros, Johan M, Wesseling, Pieter, and Smits, Marion

Published
2023
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227. In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

Author

Mir, Shahryar E., De Witt Hamer, Philip C., Krawczyk, Przemek M., Balaj, Leonora, Claes, An, Niers, Johanna M., Van Tilborg, Angela A.G., Zwinderman, Aeilko H., Geerts, Dirk, Kaspers, Gertjan J.L., Peter Vandertop, W., Cloos, Jacqueline, Tannous, Bakhos A., Wesseling, Pieter, Aten, Jacob A., Noske, David P., Van Noorden, Cornelis J.F., and Würdinger, Thomas

Published
2010
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229. Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

Author

Sievers, Philipp, primary, Henneken, Sophie C., additional, Blume, Christina, additional, Sill, Martin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Okonechnikov, Konstantin, additional, Reuss, David E., additional, Benzel, Julia, additional, Maaß, Kendra K., additional, Kool, Marcel, additional, Sturm, Dominik, additional, Zheng, Tuyu, additional, Ghasemi, David R., additional, Kohlhof-Meinecke, Patricia, additional, Cruz, Ofelia, additional, Suñol, Mariona, additional, Lavarino, Cinzia, additional, Ruf, Viktoria, additional, Boldt, Henning B., additional, Pagès, Mélanie, additional, Pouget, Celso, additional, Schweizer, Leonille, additional, Kranendonk, Mariëtte E. G., additional, Akhtar, Noreen, additional, Bunkowski, Stephanie, additional, Stadelmann, Christine, additional, Schüller, Ulrich, additional, Mueller, Wolf C., additional, Dohmen, Hildegard, additional, Acker, Till, additional, Harter, Patrick N., additional, Mawrin, Christian, additional, Beschorner, Rudi, additional, Brandner, Sebastian, additional, Snuderl, Matija, additional, Abdullaev, Zied, additional, Aldape, Kenneth, additional, Gilbert, Mark R., additional, Armstrong, Terri S., additional, Ellison, David W., additional, Capper, David, additional, Ichimura, Koichi, additional, Reifenberger, Guido, additional, Grundy, Richard G., additional, Jabado, Nada, additional, Krskova, Lenka, additional, Zapotocky, Michal, additional, Vicha, Ales, additional, Varlet, Pascale, additional, Wesseling, Pieter, additional, Rutkowski, Stefan, additional, Korshunov, Andrey, additional, Wick, Wolfgang, additional, Pfister, Stefan M., additional, Jones, David T. W., additional, von Deimling, Andreas, additional, Pajtler, Kristian W., additional, and Sahm, Felix, additional

Published
2021
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233. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Author

Stupp, Roger, Hegi, Monika E, Mason, Warren P, van den Bent, Martin J, Taphoorn, Martin JB, Janzer, Robert C, Ludwin, Samuel K, Allgeier, Anouk, Fisher, Barbara, Belanger, Karl, Hau, Peter, Brandes, Alba A, Gijtenbeek, Johanna, Marosi, Christine, Vecht, Charles J, Mokhtari, Karima, Wesseling, Pieter, Villa, Salvador, Eisenhauer, Elizabeth, Gorlia, Thierry, Weller, Michael, Lacombe, Denis, Cairncross, J Gregory, and Mirimanoff, René-Olivier

Published
2009
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234. Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1

Author

Sievers, Philipp, Sill, Martin, Blume, Christina, Tauziede-Espariat, Arnault, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Dogan, Helin, Hartmann, Christian, Mawrin, Christian, Hasselblatt, Martin, Stummer, Walter, Schick, Uta, Hench, Jürgen, Frank, Stephan, Ketter, Ralf, Schweizer, Leonille, Schittenhelm, Jens, Puget, Stéphanie, Brandner, Sebastian, Jaunmuktane, Zane, Küsters, Benno, Abdullaev, Zied, Pekmezci, Melike, Snuderl, Matija, Ratliff, Miriam, Herold-Mende, Christel, Unterberg, Andreas, Aldape, Kenneth, Ellison, David W, Wesseling, Pieter, Reifenberger, Guido, Wick, Wolfgang, Perry, Arie, Varlet, Pascale, Pfister, Stefan M, Jones, David TW, von Deimling, Andreas, Sahm, Felix, and German Consortium 'Aggressive Meningiomas'

Subjects
Male, German Consortium “Aggressive Meningiomas”, DNA Mutational Analysis, Clinical Sciences, DNA methylation profile, Cohort Studies, Young Adult, Rare Diseases, Genetic, otorhinolaryngologic diseases, Genetics, Humans, 2.1 Biological and endogenous factors, Aetiology, Child, neoplasms, Clear cell, Cancer, Pediatric, Neurology & Neurosurgery, Brain Neoplasms, Human Genome, Neurosciences, Non-Histone, DNA, DNA Methylation, SMARCE1, Immunohistochemistry, nervous system diseases, Brain Disorders, Brain tumor, Chromosomal Proteins, DNA-Binding Proteins, Brain Cancer, Neoplasm Recurrence, Treatment Outcome, Local, Mutation, Disease Progression, Neoplasm, Female, Meningioma, Epigenesis, Genome-Wide Association Study
Abstract

Clear cell meningioma represents an uncommon variant of meningioma that typically affects children and young adults. Although an enrichment of loss-of-function mutations in the SMARCE1 gene has been reported for this subtype, comprehensive molecular investigations are lacking. Here we describe a molecularly distinct subset of tumors (n = 31), initially identified through genome-wide DNA methylation screening among a cohort of 3093 meningiomas, of which most were diagnosed histologically as clear cell meningioma. This cohort was further supplemented by an additional 11 histologically diagnosed clear cell meningiomas for analysis (n = 42). Targeted DNA sequencing revealed SMARCE1 mutations in 33/34 analyzed samples, accompanied by a nuclear loss of expression determined via immunohistochemistry and a decreased SMARCE1 transcript expression in the tumor cells. Analysis of time to progression or recurrence of patients within the clear cell meningioma group (n = 14) in comparison to those with meningioma WHO grade 2 (n = 220) revealed a similar outcome and support the assignment of WHO grade 2 to these tumors. Our findings indicate the existence of a highly distinct epigenetic signature of clear cell meningiomas, separate from all other variants of meningiomas, with recurrent mutations in the SMARCE1 gene. This suggests that these tumors may arise from a different precursor cell population than the broad spectrum of the other meningioma subtypes.

Published
2021

239. Optical genome mapping identifies a germline retrotransposon insertion inSMARCB1in two siblings with atypical teratoid rhabdoid tumors

Author

Sabatella, Mariangela, primary, Mantere, Tuomo, additional, Waanders, Esmé, additional, Neveling, Kornelia, additional, Mensenkamp, Arjen R, additional, Dijk, Freerk, additional, Hehir‐Kwa, Jayne Y, additional, Derks, Ronnie, additional, Kwint, Michael, additional, O'Gorman, Luke, additional, Tropa Martins, Madalena, additional, Gidding, Corrie EM, additional, Lequin, Maarten H, additional, Küsters, Benno, additional, Wesseling, Pieter, additional, Nelen, Marcel, additional, Biegel, Jacklyn A, additional, Hoischen, Alexander, additional, Jongmans, Marjolijn C, additional, and Kuiper, Roland P, additional

Published
2021
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240. Abstract 3147: Stereotactic image-guided epigenome profiling reveals a neural stem cell evolutionary origin of diffuse gliomas

Author

Barthel, Floris P., primary, Verburg, Niels, additional, Rockne, Russell, additional, Eijgelaar, Roelant, additional, Anderson, Kevin, additional, Müller, Domenique, additional, Branciamore, Sergio, additional, Johnson, Kevin C., additional, Wesseling, Pieter, additional, Hamer, Philip C. de Witt, additional, and Verhaak, Roel G., additional

Published
2021
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241. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

Author

Louis, David N, primary, Perry, Arie, additional, Wesseling, Pieter, additional, Brat, Daniel J, additional, Cree, Ian A, additional, Figarella-Branger, Dominique, additional, Hawkins, Cynthia, additional, Ng, H K, additional, Pfister, Stefan M, additional, Reifenberger, Guido, additional, Soffietti, Riccardo, additional, von Deimling, Andreas, additional, and Ellison, David W, additional

Published
2021
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242. Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study

Author

von Hoff, Katja, primary, Haberler, Christine, additional, Schmitt-Hoffner, Felix, additional, Schepke, Elizabeth, additional, de Rojas, Teresa, additional, Jacobs, Sandra, additional, Zapotocky, Michal, additional, Sumerauer, David, additional, Perek-Polnik, Marta, additional, Dufour, Christelle, additional, van Vuurden, Dannis, additional, Slavc, Irene, additional, Gojo, Johannes, additional, Pickles, Jessica C, additional, Gerber, Nicolas U, additional, Massimino, Maura, additional, Gil-da-Costa, Maria Joao, additional, Garami, Miklos, additional, Kumirova, Ella, additional, Sehested, Astrid, additional, Scheie, David, additional, Cruz, Ofelia, additional, Moreno, Lucas, additional, Cho, Jaeho, additional, Zeller, Bernward, additional, Bovenschen, Niels, additional, Grotzer, Michael, additional, Alderete, Daniel, additional, Snuderl, Matija, additional, Zheludkova, Olga, additional, Golanov, Andrey, additional, Okonechnikov, Konstantin, additional, Mynarek, Martin, additional, Juhnke, Björn Ole, additional, Rutkowski, Stefan, additional, Schüller, Ulrich, additional, Pizer, Barry, additional, von Zezschwitz, Barbara, additional, Kwiecien, Robert, additional, Wechsung, Maximilian, additional, Konietschke, Frank, additional, Hwang, Eugene I, additional, Sturm, Dominik, additional, Pfister, Stefan M, additional, von Deimling, Andreas, additional, Rushing, Elisabeth J, additional, Ryzhova, Marina, additional, Hauser, Peter, additional, Łastowska, Maria, additional, Wesseling, Pieter, additional, Giangaspero, Felice, additional, Hawkins, Cynthia, additional, Figarella-Branger, Dominique, additional, Eberhart, Charles, additional, Burger, Peter, additional, Gessi, Marco, additional, Korshunov, Andrey, additional, Jacques, Tom S, additional, Capper, David, additional, Pietsch, Torsten, additional, and Kool, Marcel, additional

Published
2021
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243. Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study

Author

van den Bent, Martin J, primary, Tesileanu, C Mircea S, additional, Wick, Wolfgang, additional, Sanson, Marc, additional, Brandes, Alba Ariela, additional, Clement, Paul M, additional, Erridge, Sarah, additional, Vogelbaum, Michael A, additional, Nowak, Anna K, additional, Baurain, Jean Français, additional, Mason, Warren P, additional, Wheeler, Helen, additional, Chinot, Olivier L, additional, Gill, Sanjeev, additional, Griffin, Matthew, additional, Rogers, Leland, additional, Taal, Walter, additional, Rudà, Roberta, additional, Weller, Michael, additional, McBain, Catherine, additional, Reijneveld, Jaap, additional, Enting, Roelien H, additional, Caparrotti, Francesca, additional, Lesimple, Thierry, additional, Clenton, Susan, additional, Gijtenbeek, Anja, additional, Lim, Elizabeth, additional, Herrlinger, Ulrich, additional, Hau, Peter, additional, Dhermain, Frederic, additional, de Heer, Iris, additional, Aldape, Kenneth, additional, Jenkins, Robert B, additional, Dubbink, Hendrikus Jan, additional, Kros, Johan M, additional, Wesseling, Pieter, additional, Nuyens, Sarah, additional, Golfinopoulos, Vassilis, additional, Gorlia, Thierry, additional, French, Pim, additional, and Baumert, Brigitta G, additional

Published
2021
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244. Clinical characteristics of subsequent histologically confirmed meningiomas in long-term childhood cancer survivors: A Dutch LATER study

Author

Verbruggen, Lisanne C., primary, Kok, Judith L., additional, Teepen, Jop C., additional, Janssens, Geert O., additional, de Boer, Charlotte M., additional, Stalpers, Lukas J.A., additional, Vernooij, Meike W., additional, van Dulmen-den Broeder, Eline, additional, Loonen, Jacqueline J., additional, van den Heuvel-Eibrink, Marry M., additional, Tissing, Wim J.E., additional, van der Heiden-van der Loo, Margriet, additional, Versluys, Anne Birgitta, additional, Neggers, Sebastian J.C.M.M., additional, van Leeuwen, Flora E., additional, Hoving, Eelco W., additional, Wesseling, Pieter, additional, Kremer, Leontine C.M., additional, Ronckers, Cécile M., additional, van der Pal, Helena J.H., additional, Louwerens, Marloes, additional, de Vries, Andrica, additional, Jaspers, Monique, additional, Hollema, Nynke, additional, den Hartogh, Jaap, additional, and Schouten-van Meeteren, Netteke, additional

Published
2021
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245. Spatial concordance of DNA methylation classification in diffuse glioma

Author

Verburg, Niels, primary, Barthel, Floris P, additional, Anderson, Kevin J, additional, Johnson, Kevin C, additional, Koopman, Thomas, additional, Yaqub, Maqsood M, additional, Hoekstra, Otto S, additional, Lammertsma, Adriaan A, additional, Barkhof, Frederik, additional, Pouwels, Petra J W, additional, Reijneveld, Jaap C, additional, Rozemuller, Annemieke J M, additional, Beliën, Jeroen A M, additional, Boellaard, Ronald, additional, Taylor, Michael D, additional, Das, Sunit, additional, Costello, Joseph F, additional, Vandertop, William Peter, additional, Wesseling, Pieter, additional, de Witt Hamer, Philip C, additional, and Verhaak, Roel G W, additional

Published
2021
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246. Distribution of GOPC:ROS1 and other ROS1 fusions in glioma types

Author

Sievers, Philipp, primary, Stichel, Damian, additional, Sill, Martin, additional, Schrimpf, Daniel, additional, Sturm, Dominik, additional, Selt, Florian, additional, Ecker, Jonas, additional, Miele, Evelina, additional, Kranendonk, Mariëtte E. G., additional, Tops, Bastiaan B. J., additional, Kohlhof-Meinecke, Patricia, additional, Beschorner, Rudi, additional, Kramm, Christof M., additional, Hasselblatt, Martin, additional, Reifenberger, Guido, additional, Capper, David, additional, Wesseling, Pieter, additional, Milde, Till, additional, Korshunov, Andrey, additional, Witt, Olaf, additional, Pfister, Stefan M., additional, Wick, Wolfgang, additional, von Deimling, Andreas, additional, Jones, David T. W., additional, and Sahm, Felix, additional

Published
2021
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247. Spatial concordance of DNA methylation classification in diffuse glioma.

Author

Verburg, Niels, Verburg, Niels, Barthel, Floris P, Anderson, Kevin J, Johnson, Kevin C, Koopman, Thomas, Yaqub, Maqsood M, Hoekstra, Otto S, Lammertsma, Adriaan A, Barkhof, Frederik, Pouwels, Petra JW, Reijneveld, Jaap C, Rozemuller, Annemieke JM, Beliën, Jeroen AM, Boellaard, Ronald, Taylor, Michael D, Das, Sunit, Costello, Joseph F, Vandertop, William Peter, Wesseling, Pieter, de Witt Hamer, Philip C, Verhaak, Roel GW, Verburg, Niels, Verburg, Niels, Barthel, Floris P, Anderson, Kevin J, Johnson, Kevin C, Koopman, Thomas, Yaqub, Maqsood M, Hoekstra, Otto S, Lammertsma, Adriaan A, Barkhof, Frederik, Pouwels, Petra JW, Reijneveld, Jaap C, Rozemuller, Annemieke JM, Beliën, Jeroen AM, Boellaard, Ronald, Taylor, Michael D, Das, Sunit, Costello, Joseph F, Vandertop, William Peter, Wesseling, Pieter, de Witt Hamer, Philip C, and Verhaak, Roel GW

Abstract

BackgroundIntratumoral heterogeneity is a hallmark of diffuse gliomas. DNA methylation profiling is an emerging approach in the clinical classification of brain tumors. The goal of this study is to investigate the effects of intratumoral heterogeneity on classification confidence.MethodsWe used neuronavigation to acquire 133 image-guided and spatially separated stereotactic biopsy samples from 16 adult patients with a diffuse glioma (7 IDH-wildtype and 2 IDH-mutant glioblastoma, 6 diffuse astrocytoma, IDH-mutant and 1 oligodendroglioma, IDH-mutant and 1p19q codeleted), which we characterized using DNA methylation arrays. Samples were obtained from regions with and without abnormalities on contrast-enhanced T1-weighted and fluid-attenuated inversion recovery MRI. Methylation profiles were analyzed to devise a 3-dimensional reconstruction of (epi)genetic heterogeneity. Tumor purity was assessed from clonal methylation sites.ResultsMolecular aberrations indicated that tumor was found outside imaging abnormalities, underlining the infiltrative nature of this tumor and the limitations of current routine imaging modalities. We demonstrate that tumor purity is highly variable between samples and explains a substantial part of apparent epigenetic spatial heterogeneity. We observed that DNA methylation subtypes are often, but not always, conserved in space taking tumor purity and prediction accuracy into account.ConclusionOur results underscore the infiltrative nature of diffuse gliomas and suggest that DNA methylation subtypes are relatively concordant in this tumor type, although some heterogeneity exists.

Published
2021

248. Sarcoma classification by DNA methylation profiling

Author

Koelsche, Christian, Schrimpf, Daniel, Stichel, Damian, Sill, Martin, Sahm, Felix, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Heilig, Christoph E., Beck, Katja, Horak, Peter, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Ecker, Jonas, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K., Sievers, Philipp, Ebrahimi, Azadeh, Suwala, Abigail, Fernandez-Klett, Francisco, Casalini, Belen, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Perez, Laura, Gruenewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael, Unterberg, Andreas, Uhl, Matthias, Abdollahi, Amir, Debus, Juergen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Juergen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Mentzel, Thomas, Griewank, Klaus, de Alava, Enrique, Martin, Juan Diaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel, Mynarek, Martin, Rutkowski, Stefan, Schueller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija, Buettner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian, Jaunmuktane, Zane, Lyskjaer, Iben, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Heining, Christoph, Tirado, Oscar M., Sainz-Jaspeado, Miguel, Mora, Jaume, Alonso, Javier, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Vokuhl, Christian, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Capper, David, Jones, David T. W., Froehling, Stefan, Pfister, Stefan M., von Deimling, Andreas, Koelsche, Christian, Schrimpf, Daniel, Stichel, Damian, Sill, Martin, Sahm, Felix, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Heilig, Christoph E., Beck, Katja, Horak, Peter, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Ecker, Jonas, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K., Sievers, Philipp, Ebrahimi, Azadeh, Suwala, Abigail, Fernandez-Klett, Francisco, Casalini, Belen, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Perez, Laura, Gruenewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael, Unterberg, Andreas, Uhl, Matthias, Abdollahi, Amir, Debus, Juergen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Juergen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Mentzel, Thomas, Griewank, Klaus, de Alava, Enrique, Martin, Juan Diaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel, Mynarek, Martin, Rutkowski, Stefan, Schueller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija, Buettner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian, Jaunmuktane, Zane, Lyskjaer, Iben, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Heining, Christoph, Tirado, Oscar M., Sainz-Jaspeado, Miguel, Mora, Jaume, Alonso, Javier, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Vokuhl, Christian, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Capper, David, Jones, David T. W., Froehling, Stefan, Pfister, Stefan M., and von Deimling, Andreas

Abstract

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications. Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.

Published
2021

249. Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial

Author

Compter, Inge, Compter, Inge, Eekers, Danielle B. P., Hoeben, Ann, Rouschop, Kasper M. A., Reymen, Bart, Ackermans, Linda, Beckervordersantforth, Jan, Bauer, Noel J. C., Anten, Monique M., Wesseling, Pieter, Postma, Alida A., De Ruysscher, Dirk, Lambin, Philippe, Compter, Inge, Compter, Inge, Eekers, Danielle B. P., Hoeben, Ann, Rouschop, Kasper M. A., Reymen, Bart, Ackermans, Linda, Beckervordersantforth, Jan, Bauer, Noel J. C., Anten, Monique M., Wesseling, Pieter, Postma, Alida A., De Ruysscher, Dirk, and Lambin, Philippe

Abstract

Treatment of glioblastoma xenografts with chloroquine results in macroautophagy/autophagy inhibition, resulting in a reduction of tumor hypoxia and sensitization to radiation. Preclinical data show thatEGFRvIII-expressing glioblastoma may benefit most from chloroquine because of autophagy dependency. This study is the first to explore the safety, pharmacokinetics and maximum tolerated dose of chloroquine in combination with radiotherapy and concurrent daily temozolomide in patients with a newly diagnosed glioblastoma. This study is a single-center, open-label, dose-finding phase I trial. Patients received oral chloroquine daily starting one week before the course of chemoradiation (temozolomide 75 mg/m(2)/d) until the end of radiotherapy (59.4 Gy/33 fractions). Thirteen patients were included in the study (n = 6: 200 mg, n = 3: 300 mg, n = 4: 400 mg chloroquine). A total of 44 adverse events, possibly related to chloroquine, were registered including electrocardiogram QTc prolongation, irreversible blurred vision and nausea/vomiting resulting in cessation of temozolomide or delay of adjuvant cycles. The maximum tolerated dose was 200 mg chloroquine. Median overall survival was 16 months (range 2-32). Median survival was 11.5 months forEGFRvIII- patients and 20 months forEGFRvIII+ patients. A daily dose of 200 mg chloroquine was determined to be the maximum tolerated dose when combined with radiotherapy and concurrent temozolomide for newly diagnosed glioblastoma. Favorable toxicity and promising overall survival support further clinical studies.

Published
2021

250. Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations.

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Tesileanu, C Mircea S, Vallentgoed, Wies R, Sanson, Marc, Taal, Walter, Clement, Paul M, Wick, Wolfgang, Brandes, Alba Ariela, Baurain, Jean-François, Chinot, Olivier L, Wheeler, Helen, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H, Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, de Vos, Filip, Mulholland, Paul J, Taphoorn, Martin J B, de Heer, Iris, Hoogstrate, Youri, de Wit, Maurice, Boggiani, Lorenzo, Venneker, Sanne, Oosting, Jan, Bovée, Judith V M G, Erridge, Sara, Vogelbaum, Michael A, Nowak, Anna K, Mason, Warren P, Kros, Johan M, Wesseling, Pieter, Aldape, Ken, Jenkins, Robert B, Dubbink, Hendrikus J, Baumert, Brigitta, Golfinopoulos, Vassilis, Gorlia, Thierry, van den Bent, Martin, French, Pim J, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Tesileanu, C Mircea S, Vallentgoed, Wies R, Sanson, Marc, Taal, Walter, Clement, Paul M, Wick, Wolfgang, Brandes, Alba Ariela, Baurain, Jean-François, Chinot, Olivier L, Wheeler, Helen, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H, Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, de Vos, Filip, Mulholland, Paul J, Taphoorn, Martin J B, de Heer, Iris, Hoogstrate, Youri, de Wit, Maurice, Boggiani, Lorenzo, Venneker, Sanne, Oosting, Jan, Bovée, Judith V M G, Erridge, Sara, Vogelbaum, Michael A, Nowak, Anna K, Mason, Warren P, Kros, Johan M, Wesseling, Pieter, Aldape, Ken, Jenkins, Robert B, Dubbink, Hendrikus J, Baumert, Brigitta, Golfinopoulos, Vassilis, Gorlia, Thierry, van den Bent, Martin, and French, Pim J

Abstract

Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency in several tumour types. Even though these mutations are confined to distinct hotspots, we show that gliomas are the only tumour type with an exceptionally high percentage of IDH1 mutations. Patients harbouring IDH1 mutated tumours have lower levels of genome-wide DNA-methylation, and an associated increased gene expression, compared to tumours with other IDH1/2 mutations ("non-R132H IDH1/2 mutations"). This reduced methylation is seen in multiple tumour types and thus appears independent of the site of origin. For 1p/19q non-codeleted glioma (astrocytoma) patients, we show that this difference is clinically relevant: in samples of the randomised phase III CATNON trial, patients harbouring tumours with IDH mutations other than IDH1 have a better outcome (hazard ratio 0.41, 95% CI [0.24, 0.71], p = 0.0013). Such non-R132H IDH1/2-mutated tumours also had a significantly lower proportion of tumours assigned to prognostically poor DNA-methylation classes (p < 0.001). IDH mutation-type was independent in a multivariable model containing known clinical and molecular prognostic factors. To confirm these observations, we validated the prognostic effect of IDH mutation type on a large independent dataset. The observation that non-R132H IDH1/2-mutated astrocytomas have a more favourable prognosis than their IDH1 mutated counterpart indicates that not all IDH-mutations are identical. This difference is clinically relevant and should be taken into account for patient prognostication.

Published
2021

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