568 results on '"Weiller, P.-J."'
Search Results
202. [Impaired visual acuity in Mediterranean boutonneuse fever].
- Author
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Granel B, Serratrice J, Rey J, Conrath J, Disdier P, and Weiller PJ
- Subjects
- Adult, Diagnosis, Differential, Fluorescein Angiography, Humans, Male, Boutonneuse Fever diagnosis, Macular Edema diagnosis, Retinal Hemorrhage diagnosis, Visual Acuity
- Published
- 2001
203. Antibodies to phosphatidylethanolamine as the only antiphospholipid antibodies found in patients with unexplained thromboses.
- Author
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Sanmarco M, Alessi MC, Harle JR, Sapin C, Aillaud MF, Gentile S, Juhan-Vague I, and Weiller PJ
- Subjects
- Adult, Antiphospholipid Syndrome blood, Antiphospholipid Syndrome immunology, Female, France epidemiology, Humans, Immunoglobulin Isotypes blood, Lupus Erythematosus, Systemic blood, Lupus Erythematosus, Systemic immunology, Male, Middle Aged, Prevalence, Thrombophilia blood, Thrombophilia immunology, Thrombosis etiology, Thrombosis immunology, Antibodies, Antiphospholipid blood, Autoantibodies blood, Phosphatidylethanolamines immunology, Thrombosis epidemiology
- Abstract
The objective of this study was to assess the interest of antiphosphatidylethanolamine antibodies (aPE) in unexplained thrombosis (UT) defined as thrombotic episode without any of the main autoimmune and hereditary thrombophilic defects. Results from 98 UT were compared to those of (I) 142 patients with thrombophilia: 67 antiphospholipid syndrome (APS) and 75 hereditary hemostatic defects (HHD); (II) 110 patients without thrombosis: 60 with systemic lupus erythematosus (SLE) and 50 with infectious diseases (ID). As compared to controls (100 blood donors), aPE prevalence was significantly higher in both autoimmune contexts (APS: 43%; SLE: 40%, p<0.0001) and among non-autoimmune pathologies, only in UT (18%, p = 0.001) conversely to HHD (8%) or ID (10%). aPE prevalence in UT was not statistically different from that found in Primary APS (32%, p = 0.076) but lower than in Secondary APS (65%, p <0.005). In UT, aPE were mainly of IgM isotype like in Primary APS and they were found alone whereas in SLE they were always associated with classical antiphospholipid antibodies. No significant association was found between any isotype of aPE and a site of thrombosis in UT as well as in APS. In conclusion, this study demonstrates an increase of the prevalence of aPE in patients with unexplained thrombosis. Thus, aPE investigation appears to be of interest in UT and their persistent presence could define a biological variant of APS.
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- 2001
204. Pickwickian syndrome and vanishing finger pebbles.
- Author
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Granel B, Serratrice J, Mohamed H, Weiller-Merli C, Hesse-Bonerandi S, Raccah D, Rojat-Habib MC, Disdier P, Bonerandi JJ, and Weiller PJ
- Subjects
- Adult, Biopsy, Follow-Up Studies, Hand Dermatoses etiology, Hand Dermatoses pathology, Humans, Male, Obesity Hypoventilation Syndrome diet therapy, Skin pathology, Skin Diseases pathology, Time Factors, Weight Loss, Fingers, Obesity Hypoventilation Syndrome complications, Skin Diseases etiology
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- 2001
205. [Stevens-Johnson syndrome followed by Gougerot-Sjögren syndrome].
- Author
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de Roux Serratrice C, Serratrice J, Granel B, Weiller-Merli C, Rey J, Lepidi H, Disdier P, and Weiller PJ
- Subjects
- Adult, Antibodies, Antinuclear analysis, Biopsy, Diagnosis, Differential, Female, Fluorescent Antibody Technique, Indirect, Follow-Up Studies, Humans, Salivary Glands pathology, Sjogren's Syndrome diagnosis, Sjogren's Syndrome immunology, Sjogren's Syndrome pathology, Time Factors, Sjogren's Syndrome etiology, Stevens-Johnson Syndrome complications
- Abstract
Background: Sicca syndrome after Stevens-Johnson syndrome is classically described. However, to our knowledge, authentic Sjögren's syndrome following epidermal necrolysis has not been described previously., Case Report: A 36-year-old woman with Steven-Johnson syndrome developed transient hepatitis and a persistent sicca syndrome. Fourteen years later an authentic Sjögren's syndrome was identified with presence of antinuclear and anti-SSA antibodies and lymphocytes infiltration of the accessory salivary glands, i.e. grade IV disease in the Chisholm classification., Discussion: The initial mucosal destruction observed in our patients may have laid the ground for Sjögren's syndrome via abnormal antigen presentation in a predisposed dysimmune context.
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- 2001
206. [Psychological and behavioral disorders with good outcome in neurosarcoidosis].
- Author
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Granel B, Gaudy C, Serratrice J, de Roux-Serratrice C, Félician O, Swiader L, Pache X, Ceccaldi M, Balzamo M, Donnet A, Manera L, Raybaud C, Disdier P, and Weiller PJ
- Subjects
- Adult, Antirheumatic Agents therapeutic use, Cognition Disorders diagnosis, Drug Therapy, Combination, Female, Humans, Hydroxychloroquine therapeutic use, Magnetic Resonance Imaging, Methotrexate therapeutic use, Nervous System Diseases diagnosis, Nervous System Diseases drug therapy, Paranoid Disorders diagnosis, Prednisolone therapeutic use, Prognosis, Sarcoidosis diagnosis, Sarcoidosis drug therapy, Treatment Outcome, Cognition Disorders etiology, Facial Paralysis etiology, Meningitis etiology, Nervous System Diseases etiology, Neurocognitive Disorders etiology, Paranoid Disorders etiology, Sarcoidosis etiology
- Abstract
Introduction: Neurological involvement is observed in 5% of cases of sarcoidosis and includes impairment of the central nervous system, the meninges, and the cranial and peripheral nerves. Besides neurological defects, cognitive impairment may be encountered ranging from isolated memory defect to dementia., Exegesis: We report a case of neurosarcoidosis occurring in a 40-year-old woman, a native of Reunion Island, with initial meningeal and hypophyseal involvement. Three years later, while treated with low dose prednisolone and methotrexate, she presented a paranoid state associated with cognitive impairment of frontal type and severe behavioral disturbances. After 2 years of high dose steroid treatment associated with hydroxychloroquine, her behavioral status improved, allowing social and familial reinsertion., Conclusion: In our observation, sarcoidosis was revealed through a central neurological impairment, with chronic meningitis, facial nerve palsy, and, finally, through psychiatric symptoms and severe behavioral disturbances. A slow favorable outcome was obtained using high dose methylprednisolone and hydroxychloroquine with total regression of behavioral disturbances but with persisting cognitive alteration.
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- 2001
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207. Recurrent glomerulonephritis in relapsing polychondritis.
- Author
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Daniel L, Granel B, Dussol B, Weiller PJ, and Pellissier JF
- Subjects
- Female, Glomerulonephritis immunology, Glomerulonephritis pathology, Humans, Middle Aged, Polychondritis, Relapsing immunology, Polychondritis, Relapsing pathology, Recurrence, T-Lymphocytes immunology, Glomerulonephritis etiology, Polychondritis, Relapsing complications
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- 2001
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208. A nucleotide insertion and frameshift cause albumin Kénitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges.
- Author
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Minchiotti L, Campagnoli M, Rossi A, Cosulich ME, Monti M, Pucci P, Kragh-Hansen U, Granel B, Disdier P, Weiller PJ, and Galliano M
- Subjects
- Adenine, Amino Acid Sequence, Codon, Terminator, Cyanogen Bromide, Disulfides chemistry, Exons, Humans, Jews, Mass Spectrometry, Molecular Sequence Data, Morocco, Oligosaccharides chemistry, Peptide Fragments chemistry, Peptide Mapping, Serum Albumin, Human, Frameshift Mutation, Glycoproteins chemistry, Glycoproteins genetics, Serum Albumin chemistry, Serum Albumin genetics
- Abstract
Albumin Kenitra is a new type of genetic variant of human serum albumin that has been found in two members of a family of Sephardic Jews from Kenitra (Morocco). The slow-migrating variant and the normal protein were isolated by anion-exchange chromatography and, after treatment with CNBr, the digests were analyzed by two-dimensional electrophoresis in a polyacrylamide gel. The CNBr peptides of the variant were purified by reverse-phase high performance liquid chromatography and submitted to sequence analysis. Albumin Kenitra is peculiar because it has an elongated polypeptide chain, 601 residues instead of 585, and its sequence is modified beginning from residue 575. DNA structural studies showed that the variant is caused by a single-base insertion, an adenine at nucleotide position 15 970 in the genomic sequence, which leads to a frameshift with the subsequent translation to the first termination codon of exon 15. Mass spectrometric analyses revealed that the four additional cysteine residues of the variant form two new S-S bridges and showed that albumin Kenitra is partially O-glycosylated by a monosialylated HexHexNAc structure. This oligosaccharide chain has been located to Thr596 by amino-acid sequence analysis of the tryptic fragment 592-597.
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- 2001
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209. A case of polymyositis with anti-histidyl-t-RNA synthetase (Jo-1) antibody syndrome following extensive vinyl chloride exposure.
- Author
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Serratrice J, Granel B, Pache X, Disdier P, De Roux-Serratrice C, Pellissier JF, and Weiller PJ
- Subjects
- Antibodies, Antinuclear analysis, Follow-Up Studies, Humans, Male, Middle Aged, Occupational Diseases immunology, Polymyositis diagnosis, Risk Assessment, Syndrome, Time Factors, Antibodies, Antinuclear immunology, Occupational Diseases chemically induced, Occupational Exposure adverse effects, Polymyositis chemically induced, Vinyl Chloride adverse effects
- Abstract
Occupational exposure to vinyl chloride monomers is known to induce Raynaud's phenomenon, periportal fibrosis, liver angiosarcoma and scleroderma-like syndrome. We report the first case of occupational polymyositis in a 58-year-old man exposed to vinyl chloride. A dysimmune process was strongly suspected as having induced vinyl chloride disease. Our patient had an anti-histidyl-t-RNA-synthetase (Jo1) antibody, which has never to our knowledge been reported in this occupational disease.
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- 2001
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210. Cannabis arteritis revisited--ten new case reports.
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Disdier P, Granel B, Serratrice J, Constans J, Michon-Pasturel U, Hachulla E, Conri C, Devulder B, Swiader L, Piquet P, Branchereau A, Jouglard J, Moulin G, and Weiller PJ
- Subjects
- Adolescent, Adult, Fingers blood supply, Humans, Ischemia diagnostic imaging, Ischemia etiology, Leg blood supply, Male, Radiography, Risk Factors, Arteritis diagnosis, Arteritis etiology, Arteritis therapy, Marijuana Smoking
- Abstract
The purpose of this paper was to revisit the old concept of cannabis arteritis first described in the 1960s and report 10 new cases. Ten male patients, with a median age of 23.7 years developed subacute distal ischemia of lower or upper limbs, leading to necrosis in the toes and/or fingers and sometimes to distal limb gangrene. Two of the patients also presented with venous thrombosis and three patients were suffering from a recent Raynaud's phenomenon. Biological test results did not show evidence of the classical vascular risk factors for thrombosis. Arteriographic evaluation in all cases revealed distal abnormalities in the arteries of feet, legs, forearms, and hands resembling those of Buerger's disease. A collateral circulation sometimes with opacification of the vasa nervorum was noted. In some cases, arterial proximal atherosclerotic lesions and venous thrombosis were observed. All patients were moderate tobacco smokers and regular cannabis users. Despite treatment with ilomedine and heparin in all cases, five amputations were necessary in four patients. The vasoconstrictor effect of cannabis on the vascular system has been known for a long time. It has been shown that delta-8- and delta-9-tetrahydrocanabinols may induce peripheral vasoconstrictor activity. Cannabis arteritis resembles Buerger's disease, but patients were moderate tobacco smokers and regular cannabis users. These cases show that prolonged use of cannabis could be an additive risk factor for juvenile and young adult arteritis. Cannabis arteritis is a forgotten and severe occlusive vascular disease occurring in young adults. Search for cannabis use may be an important tool for a better knowledge of arteritis in young smokers.
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- 2001
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211. Atypical porphyria cutanea tarda in a patient with chronic myelogenous leukemia.
- Author
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Granel B, Serratrice J, Bouabdallah R, Pache X, Weiller-Merli C, Swiader L, Aquaron R, Disdier P, Nordmann Y, and Weiller PJ
- Subjects
- Aged, Humans, Male, Porphyria Cutanea Tarda complications, Pruritus etiology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive complications, Porphyria Cutanea Tarda diagnosis
- Published
- 2001
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212. A new case of hemoglobin Chesapeake.
- Author
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Granel B, Serratrice J, Badens C, Lena-Russo D, Disdier P, and Weiller PJ
- Subjects
- Diagnosis, Differential, Erythropoietin, France, Hemoglobinopathies diagnosis, Humans, Male, Middle Aged, Myeloproliferative Disorders diagnosis, Oxyhemoglobins, Polycythemia, Hemoglobins, Abnormal adverse effects
- Published
- 2001
213. Localized morphea after silicone-gel-filled breast implant.
- Author
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Granel B, Serratrice J, Gaudy C, Weiller-Merli C, Bonerandi JJ, Lepidi H, Coulomb-Marchetti B, Disdier P, and Weiller PJ
- Subjects
- Female, Humans, Middle Aged, Scleroderma, Localized pathology, Skin pathology, Breast Implants adverse effects, Scleroderma, Localized etiology, Silicone Gels adverse effects
- Published
- 2001
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214. Chronic hepatitis C virus infection associated with a generalized granuloma annulare.
- Author
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Granel B, Serratrice J, Rey J, Bouvier C, Weiller-Merli C, Disdier P, Pellissier JF, and Weiller PJ
- Subjects
- Aged, Female, Granuloma Annulare pathology, Hepatitis C, Chronic drug therapy, Humans, Interferon-alpha therapeutic use, Skin pathology, Granuloma Annulare complications, Hepatitis C, Chronic complications
- Abstract
We report the first case of generalized granuloma annulare occurring in a 65-year-old woman who was chronically infected with hepatitis C virus. Granuloma annulare totally regressed during alpha-interferon treatment. As chronic hepatitis C virus infection is frequent, a serodiagnosis would be of interest in patients who have generalized granuloma annulare. A link between these 2 diseases may be strongly suspected.
- Published
- 2000
215. Esophageal web in Zinsser-Engman-Cole-Fanconi disease.
- Author
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de Roux-Serratrice C, Serratrice J, Escoffier JM, Granel B, Disdier P, and Weiller PJ
- Subjects
- Adult, Deglutition Disorders etiology, Dilatation, Endoscopy, Esophagus pathology, Humans, Male, Dyskeratosis Congenita complications, Esophagus abnormalities
- Published
- 2000
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216. Sarcoid-like pulmonary lesions during asbestosis. A case report.
- Author
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Granel B, Serratrice J, Disdier P, Weiller PJ, Juhan V, Garbe L, and Astoul P
- Subjects
- Aged, Asbestosis diagnosis, Asbestosis drug therapy, Bronchoscopy, Follow-Up Studies, Humans, Male, Prednisolone therapeutic use, Sarcoidosis, Pulmonary diagnosis, Sarcoidosis, Pulmonary drug therapy, Tomography, X-Ray Computed, Asbestosis complications, Asbestosis pathology, Sarcoidosis, Pulmonary complications, Sarcoidosis, Pulmonary pathology
- Published
- 2000
217. Chronic lymphocytic leukemia and Hodgkin's disease. Clinicopathologic study of three cases with good prognosis.
- Author
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Serratrice De Roux C, Coso D, Bouabdallah R, Serratrice J, Disdier P, and Weiller PJ
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Female, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy, Humans, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Male, Middle Aged, Prognosis, Remission Induction, Hodgkin Disease pathology, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Neoplasms, Second Primary
- Published
- 2000
218. Acquired inhibitor of thrombin associated with an ulcerative colitis.
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Granel B, Serratrice J, Disdier P, Pache X, Weiller PJ, Morange P, and Juhan-Vague I
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- Colitis, Ulcerative blood, Colitis, Ulcerative drug therapy, Female, Gastrointestinal Agents adverse effects, Gastrointestinal Agents therapeutic use, Humans, Middle Aged, Sulfasalazine adverse effects, Sulfasalazine therapeutic use, Thrombocytosis blood, Antithrombins metabolism, Colitis, Ulcerative complications, Thrombocytosis etiology
- Published
- 2000
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219. [Spontaneous paroxysmal hypothermia. Discussion of a case of a high level athlete].
- Author
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Serratrice J, Granel B, Swiader L, de Roux-Serratrice C, Vanuxem P, Disdier P, and Weiller PJ
- Subjects
- Adolescent, Female, Humans, Periodicity, Hypothermia etiology, Hypothermia physiopathology, Tennis
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- 2000
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220. [IGM hyperimmunoglobulinemia anti-phosphatidylethanolamine antibodies of the IgM isotype: clinical and biological study of 72 patients with immune disorders].
- Author
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Granel B, Serratrice J, Hubert AM, Volot F, Pache X, Swiader L, Rossi P, Disdier P, and Weiller PJ
- Subjects
- Adult, Antiphospholipid Syndrome blood, Autoimmune Diseases immunology, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Lymphocyte Activation, Male, Middle Aged, Reference Values, Antibodies, Antiphospholipid blood, Antiphospholipid Syndrome immunology, Autoimmune Diseases blood, Immunoglobulin Isotypes blood, Immunoglobulin M blood, Phosphatidylethanolamines immunology
- Abstract
Purpose: Antiphosphatidylethanolamine antibodies (aPE) are zwitterionic antiphospholipid antibodies that have been recently described in antiphospholipid syndrome. IgM is the most frequently observed isotype. We assessed the potential relationship between serum IgM levels and their presence., Methods: Seventy-two patients (66 females, 6 males) positive for aPE of the IgM isotype were followed up for 2 years. They suffered from either an autoimmune disease or had clinical signs suggesting the existence of antiphospholipid syndrome or other immune disorders. Seventy-two control patients (58 females, 14 males) of similar age, with other immune disorders were also included in the study. For each of them, the IgM level was obtained and hyper-immunoglobulinemia M (hyper-IgM) was defined as a value upper than 2.5 g/L. Search for aPE of the IgM isotype was made using an in-house Elisa test., Results: Half of the aPE-positive patients had serum hyper-IgM, whereas none of the aPE-negative patients had hyper-IgM. All IgMs were polyclonal. There was a positive correlation (r = 0.57, P = 0.001) between the level of IgM and the optical densities obtained by Elisa. The presence of a hyper-IgM did not modify the clinical manifestations (arterial and venous thromboses, recurrent fetal losses), nor the positivity of lupus anticoagulant, anticardiolipin and anti-beta-2-glycoprotein 1 antibodies., Conclusion: The positive correlation between the IgM level and aPE level is of value, as it suggests a possible relationship between lymphocytic activation and auto-antibodies production, which does not concern only aPE. Further studies regarding the antigenic specificity of IgM will probably provide further insights on IgM and phospholipid interactions.
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- 2000
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221. [Gamstorp's disease in a Marseilles family].
- Author
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Serratrice J, Granel B, Swiader L, de Roux-Serratrice C, Azulay JP, Pouget J, Disdier P, and Weiller PJ
- Subjects
- Adult, Family Health, Female, Glucose therapeutic use, Humans, Pedigree, Potassium blood, Sodium Channels genetics, Paralysis, Hyperkalemic Periodic blood, Paralysis, Hyperkalemic Periodic diagnosis, Paralysis, Hyperkalemic Periodic genetics, Paralysis, Hyperkalemic Periodic therapy
- Abstract
Background: Primary periodic palsy is a group of muscular diseases transmitted by autosomal dominant inheritance. The characteristic features are flaccid muscular deficiency, abolition of reflexes, and dyskalemia., Case Report: A 36-year-old woman presented a 5-year history of acute episodes of myalgia, muscle contracture, and muscle paralysis involving first the hand, then all four limbs and the face, sparing the respiratory muscles. The symptoms totally regressed spontaneously within one hour or in a shorter time if the patient ingested sugar. Demonstration of hyperkalemia during an acute episode led to the diagnosis of transfer hyperkalemia typical of Gamstorp's disease. Several members of the family presented identical symptoms., Discussion: Despite progress in our understanding of this disease, diagnosis is often made late. The diagnostic strategy is however quite simple: serum potassium during an acute episode and provocation test with fasting and rest.
- Published
- 2000
222. [A new bisalbuminemia: bisalbuminemia of Kenitra].
- Author
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Granel B, Serratrice J, Galliano M, Minchiotti L, Disdier P, and Weiller PJ
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- Aged, Blood Protein Electrophoresis, Female, Humans, Mutagenesis, Insertional, Blood Protein Disorders genetics, Serum Albumin genetics
- Published
- 2000
223. [An unrecognized cause of camptocormia: proximal myotonic myopathy].
- Author
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Serratrice J, Weiller PJ, Pouget J, and Serratrice G
- Subjects
- Aged, Diagnosis, Differential, Humans, Male, Pain etiology, Kyphosis etiology, Lumbar Vertebrae pathology, Myotonic Disorders complications
- Abstract
Background: The underlying cause of camptocormia, a common condition in adults consisting of forward flexion of the trunk both in stance and gait, is often unrecognized, attributed by some to primary late-onset myopathy., Case Reports: Two patients progressively developed camptocormia. The cause was identified as a relatively new disease, proximal myotonic myopathy., Discussion: The diagnosis of proximal myotonic myopathy is based on clinical findings: myalgia and diffuse pain, gait disorders and progressive weakness of proximal muscles, electrical myotonia, cataracte in some cases, elevated gamma glutamyltranspeptidases. The disease is transmitted by autosomal dominant inheritance. This condition should be entertained as a possible cause in patients presenting an apparently primary camptocormic syndrome.
- Published
- 2000
224. [Hepatitis C with many complications...].
- Author
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Serratrice J, Granel B, Bernit E, Pache X, Swiader L, Juhan V, Blancard MF, Chrestian MA, Zanaret M, Disdier P, and Weiller PJ
- Subjects
- Adult, Face pathology, Humans, Male, Maxillary Diseases pathology, Mucorales pathogenicity, Mucormycosis pathology, Hepatitis C complications, Maxillary Diseases etiology, Mucorales isolation & purification, Mucormycosis etiology
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- 2000
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225. "Coated aorta": a new sign of Erdheim-Chester disease.
- Author
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Serratrice J, Granel B, De Roux C, Pellissier JF, Swiader L, Bartoli JM, Disdier P, and Weiller PJ
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- Aortitis pathology, Bone and Bones diagnostic imaging, Diphosphonates, Fatal Outcome, Female, Fibrosis, Histiocytosis pathology, Humans, Male, Middle Aged, Radionuclide Imaging, Radiopharmaceuticals, Technetium Compounds, Aortitis diagnostic imaging, Histiocytosis diagnostic imaging, Tomography, X-Ray Computed
- Abstract
Erdheim-Chester disease is a rare, non-Langerhans cell form of histiocytosis characterized by osteosclerosis of the metaphyseal regions of long bones, diabetes insipidus, proptosis, and retroperitoneal fibrosis. The latter usually involves the perirenal area and leads to hydronephrosis. Periaortic fibrosis is less frequent. We describe 3 unusual cases of Erdheim-Chester disease with periaortic fibrosis involving the whole aorta and leading to a "coated aorta" appearance on computed tomography scans. Faced with such a singular "coated aorta," bone scintigraphy can be very helpful when searching for Erdheim-Chester disease.
- Published
- 2000
226. [Heat shock proteins or "stress proteins"].
- Author
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Granel B, Swiader L, Serratrice J, Disdier P, and Weiller PJ
- Subjects
- Arthritis, Rheumatoid immunology, Autoimmunity, Behcet Syndrome immunology, Heat-Shock Proteins biosynthesis, Heat-Shock Proteins immunology, Humans, Lupus Erythematosus, Systemic immunology, Arthritis, Rheumatoid physiopathology, Behcet Syndrome physiopathology, Heat-Shock Proteins physiology, Lupus Erythematosus, Systemic physiopathology
- Abstract
Introduction: Heat shock proteins (HSP) are molecular chaperones which facilitate the biosynthesis and maturation of proteins within cells (protein folding). They promote assembly and disassembly of polypeptides and play a major role in cellular function, not only during the stress response but also at basal state., Current Knowledge and Key Points: As HSP are immunogenic molecules and can be expressed on cellular membranes, their role in auto-immune and inflammatory diseases, particularly in systemic lupus erythematosus, Behçet's disease and rheumatoid arthritis, has been studied. Cellular immune response of T cells and humoral response with antibodies production against HSP occurring in the course of those diseases have been observed., Future Prospects and Projects: Anti-HSP immune response might provide better understanding of the pathogenic mechanisms involved in those diseases. At present it is not known whether HSP can trigger them. Indeed, anti-HSP immunity could be induced by the immunological process or be part of a normal immunoregulatory response.
- Published
- 2000
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227. Variation in the histological pattern of nodal involvement by gamma/delta T-cell lymphoma.
- Author
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Charton-Bain MC, Brousset P, Bouabdallah R, Gaulard P, Merlio JP, Dubus P, Rostaing L, de Roux C, Weiller PJ, Hassoun J, and Xerri L
- Subjects
- Adult, Aged, Humans, Lymph Nodes immunology, Lymphoma, T-Cell immunology, Male, Middle Aged, Receptors, Antigen, T-Cell, gamma-delta immunology, Lymph Nodes pathology, Lymphoma, T-Cell pathology
- Abstract
Aims: Gamma-delta (gammadelta) T-cell non-Hodgkin's lymphomas (NHLs) usually present with liver, spleen and marrow infiltration. Lymph node involvement by gammadelta T-cell NHL has been rarely documented so far; its histological pattern needs to be further defined., Methods and Results: Two cases of nodal gammadelta T-cell NHL are reported: case 1, a 44-year-old man, presented with cytomegalovirus retinitis and superficial lymphadenopathies. Histological analysis of an inguinal lymph node showed complete destruction by a diffuse pleomorphic lymphoid proliferation, which was positive for CD2, CD3, CD43, CD45, TIA-1 and granzyme B, and displayed a gammadelta phenotype (deltaTCR1+, Vdelta1+, Vdelta2-, Vdelta3-, betaF1-). Bone marrow was normal. Case 2, a male 24-year-old patient with a history of renal transplantation, presented with hepatosplenomegaly and supraclavicular lymph node enlargement. Lymph node architecture was globally preserved. Peripheral sinuses contained scattered nests of medium-sized irregular lymphoid cells. Bone-marrow was infiltrated. Phenotype showed positivity for CD2, CD3, CD45 and TIA1 and expression of gammadelta TCR (deltaTCR1+, deltaV1+, deltaV2-, deltaV3-, betaF1-). Both patients died a short time after diagnosis., Conclusions: These observations suggest that at least two forms of nodal gammadelta T-cell NHL may be encountered: one mimicking classical alphabeta T-cell NHL, with diffuse pleomorphic cell proliferation, and one displaying sinusoidal neoplastic infiltration suggesting a close relationship with hepatosplenic gammadelta T-cell NHL.
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- 2000
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228. Conjugal HHV-8 infection with cutaneous Kaposi's sarcomas and Castleman's disease: fortuitous association or not?
- Author
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Granel B, Serratrice J, Zandotti C, Rey J, De Roux C, Horschowski N, Disdier P, and Weiller PJ
- Subjects
- Aged, Aged, 80 and over, Castleman Disease virology, Female, HIV Seronegativity, Herpesviridae Infections transmission, Humans, Male, Sarcoma, Kaposi virology, Skin Neoplasms virology, Spouses, Castleman Disease complications, Herpesviridae Infections complications, Herpesvirus 8, Human, Sarcoma, Kaposi complications, Sexually Transmitted Diseases, Viral complications, Skin Neoplasms complications
- Published
- 2000
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229. A first molecular approach towards CGG repeat expansion in FMR1 gene in systemic lupus erythematosus and in Sjögren's syndrome: a preliminary report.
- Author
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Granel B, Ravix V, Pedeillier K, Serratrice J, Disdier P, Voelckel MA, Mattei JF, and Weiller PJ
- Subjects
- Adult, Aged, Alleles, Blotting, Southern, Female, Homozygote, Humans, Middle Aged, Mutation, Polymerase Chain Reaction, Polymorphism, Genetic, Fragile X Syndrome genetics, Lupus Erythematosus, Systemic genetics, Sjogren's Syndrome genetics, Trinucleotide Repeat Expansion genetics
- Abstract
Co-occurrent autoimmune disease and fragile X syndrome has been reported in the literature and we have therefore studied the expansion of Cytosine-Guanine-Guanine (CGG) repeat in FMR1 gene in a series of females with autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome, with PCR and Southern blot methods. The average length of trinucleotide repeat was not increased in these female patients as compared with controls. These preliminary data on a short series of patients suggest a possible absence of trinucleotide repeat expansion abnormality associated with autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome.
- Published
- 2000
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230. [An unusual cause of long-term fever: Behçet disease].
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Granel B, Berbis P, Serratrice J, Pelletier J, Disdier P, and Weiller PJ
- Subjects
- Adult, Behcet Syndrome physiopathology, Colchicine therapeutic use, Female, Humans, Vaccination adverse effects, Vaccines, Combined immunology, Behcet Syndrome immunology, Fever etiology, Vaccines, Combined adverse effects
- Abstract
Background: Behçet's disease is an uncommon cause of prolonged fever. This misleading presentation is illustrated by a new case where fever occurred after polyvalent vaccination., Case Report: A 39-year-old female patient was seen for prolonged fever after returning from a trip to Africa. She had received polyvalent vaccinations prior to leaving France. At admission fever had persisted for 2 months. The diagnosis of Behçet's disease was finally established on the basis of clinical signs, buccogenital aphtosis and pathergy. Colchicine was partially effective against although low-grade persisted in the evening., Discussion: Clinicians should be aware that Behçet's disease can provoke long-term fever which can sometimes be an inaugural sign. Sensitivity tests may be useful to identify the trigger, for example polyvalent vaccination.
- Published
- 1999
231. [Lupus and macrocreatine phosphokinase induced by mesalazine: a case report].
- Author
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Granel B, Serratrice J, Charrel M, Talon L, Laugier R, Arpurt JP, Disdier P, and Weiller PJ
- Subjects
- Enzyme Induction, Female, Humans, Lupus Vulgaris enzymology, Middle Aged, Syndrome, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Creatine Kinase metabolism, Lupus Vulgaris chemically induced, Mesalamine adverse effects
- Published
- 1999
- Full Text
- View/download PDF
232. Livedo reticularis revealing a latent infective endocarditis due to Coxiella burnetti.
- Author
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Granel B, Genty I, Serratrice J, Rey J, Disdier P, Raoult D, and Weiller PJ
- Subjects
- Chronic Disease, Endocarditis, Bacterial diagnosis, Female, Humans, Middle Aged, Q Fever diagnosis, Skin Diseases, Vascular diagnosis, Endocarditis, Bacterial complications, Q Fever complications, Skin Diseases, Vascular complications
- Abstract
We report the first case of livedo reticularis revealing a latent infective endocarditis due to Coxiella burnetti. The patient, a 54-year-old woman, also had chronic thrombocytopenia and mixed cryoglobulinemia. Chronic Q fever was confirmed by serodiagnosis and livedo regressed totally with doxycycline and hydroxychloroquine.
- Published
- 1999
- Full Text
- View/download PDF
233. Catastrophic arterial reactivity during primary antiphospholipid syndrome--a case report.
- Author
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Rey J, Granel B, Disdier P, Morange P, Piquet P, Serratrice J, de Roux C, Juhan-Vague I, and Weiller PJ
- Subjects
- Adult, Angiography, Antiphospholipid Syndrome genetics, Antiphospholipid Syndrome surgery, Arm blood supply, Consanguinity, Coronary Angiography, Female, Hand blood supply, Humans, Ischemia genetics, Ischemia surgery, Recurrence, Reoperation, Thrombectomy, Thrombosis genetics, Thrombosis surgery, Antiphospholipid Syndrome diagnosis, Catastrophic Illness, Endothelium, Vascular injuries, Ischemia etiology, Leg blood supply, Needlestick Injuries, Thrombosis etiology
- Abstract
Arterial reactivity leading to acute thrombosis at the site of a needle stick injury has never been described during antiphospholipid syndrome. The authors report a case characterized by a succession of thrombotic events occurring during or immediately after arterial angiographies or arterial surgery, in which catastrophic arterial reactivity can be strongly suspected. In this particular patient, it can be postulated that damage to the endothelial cells of the vessels injured during manipulation may have precipitated or aggravated the preexisting susceptibility to thrombosis.
- Published
- 1999
- Full Text
- View/download PDF
234. [A little known cause of antiphospholipid antibodies: Castleman's disease].
- Author
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Granel B, Serratrice J, Swiader L, Rey J, de Roux C, SanMarco M, Disdier P, and Weiller PJ
- Subjects
- Adult, Castleman Disease surgery, Female, Follow-Up Studies, Humans, Time Factors, Antibodies, Antiphospholipid analysis, Castleman Disease immunology
- Published
- 1999
- Full Text
- View/download PDF
235. Value and limitations of the Duke criteria for the diagnosis of infective endocarditis.
- Author
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Habib G, Derumeaux G, Avierinos JF, Casalta JP, Jamal F, Volot F, Garcia M, Lefevre J, Biou F, Maximovitch-Rodaminoff A, Fournier PE, Ambrosi P, Velut JG, Cribier A, Harle JR, Weiller PJ, Raoult D, and Luccioni R
- Subjects
- Bacteria isolation & purification, Bacterial Infections classification, Bacterial Infections microbiology, Diagnosis, Differential, Diagnostic Errors, Echocardiography, Doppler, Color, Echocardiography, Transesophageal, Endocarditis, Bacterial classification, Endocarditis, Bacterial microbiology, Humans, Predictive Value of Tests, Reproducibility of Results, Sensitivity and Specificity, Bacterial Infections diagnosis, Endocarditis, Bacterial diagnosis
- Abstract
Objectives: The purpose of this study was to assess the value and limitations of Duke criteria for the diagnosis of infective endocarditis (IE)., Background: Duke criteria have been shown to be more sensitive in diagnosing IE than the von Reyn criteria, but the diagnosis of IE remains difficult in some patients., Methods: Both classifications were applied in 93 consecutive patients with pathologically proven IE. Blood cultures, and transthoracic and transesophageal echocardiography were performed in all patients., Results: Sensitivities for the diagnosis of IE were 56% and 76% for von Reyn and Duke criteria, respectively. Fifty-two patients were correctly classified as "probable IE" by von Reyn and "definite IE" by Duke criteria (group 1). However, discrepancies were observed in 41 patients. Eleven patients (group 2) were misclassified as "rejected" by von Reyn, but were "definite IE" by Duke criteria; this difference could be explained by negative blood cultures and positive echocardiogram in all patients. In eight patients (group 3), the diagnosis of IE was "possible" by von Reyn but "definite" by Duke criteria. This difference was essentially explained by the failure of the von Reyn classification to consider echocardiographic abnormalities as major criteria. Twenty-two patients (group 4) were misclassified as possible IE using Duke criteria, being false negative of this classification. Echocardiographic major criteria were present in 19 patients, but blood cultures were negative in 21 patients. The cause of negative blood cultures was prior antibiotic therapy in 11 patients and Q-fever endocarditis diagnosed by positive serology in three cases., Conclusions: Twenty-four percent of patients with proved IE remain misclassified as "possible IE" despite the use of Duke criteria, especially in cases of culture-negative and Q-fever IE. Increasing the diagnostic value of echographic criteria in patients with prior antibiotic therapy and typical echocardiographic findings and considering the serologic diagnosis of Q fever as a major criterion would further improve the clinical diagnosis of IE.
- Published
- 1999
- Full Text
- View/download PDF
236. Cytomegalovirus retinitis revealing a leukemic gamma/delta T-cell lymphoma.
- Author
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Bouabdallah R, de Roux C, Xerri L, Granel B, Serratrice J, and Weiller PJ
- Subjects
- Adult, Humans, Male, Receptors, Antigen, T-Cell, gamma-delta analysis, Cytomegalovirus Retinitis complications, Leukemia pathology, Lymphoma, T-Cell chemistry, Lymphoma, T-Cell pathology
- Published
- 1999
237. [Anosmia in the antiphospholipid syndrome].
- Author
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Granel B, Serratrice J, Dessi P, Disdier P, and Weiller PJ
- Subjects
- Female, Humans, Middle Aged, Antiphospholipid Syndrome complications, Olfaction Disorders etiology
- Published
- 1999
238. [Thymoma and hypogammaglobulinemia. Good's syndrome: apropos of a case and review of the literature].
- Author
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Granel B, Gayet S, Christides C, Serratrice J, Rey J, Disdier P, and Weiller PJ
- Subjects
- Agammaglobulinemia therapy, Aged, Humans, Immunoglobulins, Intravenous therapeutic use, Male, Pneumonia complications, Syndrome, Thymoma surgery, Thymus Neoplasms surgery, Agammaglobulinemia complications, Thymoma complications, Thymus Neoplasms complications
- Abstract
Introduction: Good's syndrome is defined as the association of thymoma, hypogammaglobulinemia, and repetitive bronchopulmonary infections. We report one case and review the clinical and immunological features of this syndrome., Exegesis: We describe the case of a 67-year-old man who presented with both severe bronchopulmonary infection resistant to antibiotherapy and thymoma. Definite diagnosis was based on the existence of hypogammaglobulinemia. Treatment with intravenous immunoglobulins led to positive outcome., Conclusion: Good's syndrome occurs in only 5% of parathymic diseases. To prevent further bronchial tube destruction and pulmonary surgery, it must be diagnosed and treated early.
- Published
- 1999
- Full Text
- View/download PDF
239. [Cannabis-induced arteritis vs. Léo Buerger disease. Nosologic discussion apropos of two new cases].
- Author
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Disdier P, Swiader L, Jouglard J, Piquet P, Christides C, Moulin G, Harlé JR, and Weiller PJ
- Subjects
- Adolescent, Adult, Angiography, Arm blood supply, Arm diagnostic imaging, Diagnosis, Differential, Endarteritis diagnosis, Humans, Leg blood supply, Leg diagnostic imaging, Male, Smoking adverse effects, Thromboangiitis Obliterans classification, Thromboangiitis Obliterans diagnosis, Cannabis adverse effects, Endarteritis chemically induced, Thromboangiitis Obliterans chemically induced
- Abstract
Background: We observed two cases of juvenile endarteritis which might suggest a possible link between Winiwarter-Buerger disease and cannabis-induced endarteritis., Case Reports: Our two patients were young men aged 18 and 20 years. Both developed acute distal ischemia of the lower or upper limbs with arteriographic evidence suggestive of Winiwarter-Buerger disease. Both smoked regularly but not excessively and both used cannabis regularly. In one case, the therapeutic response to withdrawal of cannabis was good. In the second, use of cannabis continued and arterial disease persisted., Discussion: The cause of Winiwarter-Buerger disease remains elusive although smoking is undoubtedly involved in the pathogenic mechanism. Our two cases recall the cannabis-induced endarteritis described in the sixties in Kif smokers in North Africa. The main clinical and radiographical features in this condition are the same as in Winiwarter-Buerger disease., Conclusion: Winiwarter-Buerger disease and cannabis-induced endarteritis are 2 very similar conditions. The probably rare finding of juvenile endarteritis mimicking thromboangeitis obliterans should, in our opinion, be considered as a secondary and possibly toxic effect of cannabis.
- Published
- 1999
240. [Diagnostic imaging...].
- Author
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Serratrice J, Granel B, de Roux C, Swiader L, Pache X, Bartoli JM, Disdier P, and Weiller PJ
- Subjects
- Bone and Bones diagnostic imaging, Diagnosis, Differential, Female, Histiocytosis, Non-Langerhans-Cell diagnosis, Humans, Middle Aged, Radionuclide Imaging, Tomography, X-Ray Computed, Histiocytosis, Non-Langerhans-Cell diagnostic imaging
- Published
- 1999
- Full Text
- View/download PDF
241. Excessive concern with physical appearance leading to a diagnosis of adrenal adenoma.
- Author
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Granel B, Serratrice J, Berbis P, Rey J, Denizot A, Disdier P, and Weiller PJ
- Subjects
- Adrenocortical Adenoma complications, Adult, Edema diagnosis, Edema psychology, Erythema diagnosis, Erythema psychology, Facial Dermatoses diagnosis, Facial Dermatoses psychology, Female, Humans, Hypertension diagnosis, Adrenocortical Adenoma diagnosis, Cushing Syndrome etiology
- Abstract
We report an unusual case of Cushing's syndrome manifested by anxiety over body image in a 26-year-old nurse. Initial presentation was a 'dermatological non-disease'. Clinical signs became increasingly evident during the course of the disease, justifying an adrenal gland evaluation which showed a secreting adrenocortical adenoma. Surgical treatment led to recovery with return to normal appearance and cessation of her aesthetic complaints. Our observation shows that persistent aesthetic complaints may sometimes reveal early hypercorticism.
- Published
- 1999
- Full Text
- View/download PDF
242. [Kaposi's disease simulating splenolymphatic lymphoma, toxoplasmosis, terminal cryptococcosis. 1979].
- Author
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Mongin M, Weiller PJ, Lammy S, Gamby T, and Lebreuil G
- Subjects
- Cryptococcosis diagnosis, Diagnosis, Differential, History, 20th Century, Humans, Lymphoma diagnosis, Splenic Neoplasms diagnosis, Toxoplasmosis diagnosis, Xeroderma Pigmentosum diagnosis, Xeroderma Pigmentosum history
- Published
- 1999
243. Asymptomatic intracardiac thrombi and primary antiphospholipid syndrome.
- Author
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Granel B, Garcia E, Serratrice J, Christides C, Swiader L, Pache X, Caus T, Disdier P, and Weiller PJ
- Subjects
- Adult, Antibodies, Antiphospholipid blood, Antiphospholipid Syndrome diagnosis, Coronary Thrombosis diagnostic imaging, Coronary Thrombosis surgery, Depressive Disorder complications, Diagnosis, Differential, Echocardiography, Female, Humans, Antiphospholipid Syndrome complications, Coronary Thrombosis etiology
- Abstract
Intracardiac thrombi have rarely been reported in patients with the antiphospholipid syndrome. We describe a new case revealed by systematic echocardiography in an asymptomatic woman who consulted for mild thrombocytopenia. Our case is characterized by a past history of migraine, fetal loss and psychiatric disturbances and by a high level of antiphospholipid antibodies (anticardiolipin, anti-beta(2)-glycoprotein I and lupus anticoagulant). Echography, in the absence of any cardiovascular symptom, showed bulky right intra-atrial thrombi requiring surgical excision. Histopathological analysis revealed the fibrino-cruoric nature of the lesion without myxoma. This case shows that, when faced with a mild thrombocytopenia associated with antiphospholipid antibodies, echocardiography may reveal a life-threatening and completely asymptomatic intracardiac thrombosis., (Copyright 2000 S. Karger AG, Basel)
- Published
- 1999
- Full Text
- View/download PDF
244. [Sudden awakening of a parasite...].
- Author
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Disdier P, Swiader L, Granel B, Jouglard J, and Weiller PJ
- Subjects
- Animals, Anticestodal Agents administration & dosage, Anticestodal Agents therapeutic use, Eosinophilia etiology, Female, Humans, Middle Aged, Niclosamide administration & dosage, Niclosamide therapeutic use, Taeniasis blood, Time Factors, Alendronate adverse effects, Taeniasis etiology
- Published
- 1998
245. Young woman's digestive arterial occlusion--a case report and literature review.
- Author
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Crètel E, Disdier P, Chagnaud C, Tournigand P, Harlé JR, Piette JC, and Weiller PJ
- Subjects
- Adult, Female, Humans, Iloprost therapeutic use, Mesenteric Arteries, Vasodilator Agents therapeutic use, Arterial Occlusive Diseases diagnosis, Arterial Occlusive Diseases drug therapy, Celiac Plexus, Mesenteric Vascular Occlusion diagnosis, Mesenteric Vascular Occlusion drug therapy
- Abstract
The authors report the observation of a 31-year-old woman who presented with total occlusion of digestive arteries and was successfully treated pharmacologically. A review of the literature shows that digestive arteries thrombosis is a rare condition in young women. Only 15 cases have been previously reported. Prognosis was poor with a mortality rate of 71%; 93% used oral contraception and more than 50% were smokers. All these cases were curiously similar. The authors accentuate the role of iloprost in the recovery of the patient. Digestive artery occlusion should be taken into consideration in the differential diagnosis of abdominal pain, especially in young women who smoke and take estrogen-containing birth control pills.
- Published
- 1998
- Full Text
- View/download PDF
246. [Pseudo-Glanzmann thrombasthenia in the course of autoimmune thrombocytopenic purpura].
- Author
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Granel B, Swiader L, Veit V, Rey J, Reviron D, Disdier P, Harlé JR, and Weiller PJ
- Subjects
- Aged, Bleeding Time, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Lupus Coagulation Inhibitor blood, Paraproteinemias blood, Paraproteinemias immunology, Platelet Aggregation, Platelet Count, Platelet Glycoprotein GPIIb-IIIa Complex immunology, Thrombasthenia blood, Thrombasthenia immunology, Time Factors, Autoantibodies blood, Paraproteinemias diagnosis, Purpura, Thrombocytopenic, Idiopathic surgery, Splenectomy, Thrombasthenia diagnosis
- Abstract
Introduction: Auto-immune thrombocytopenic purpura is associated with platelet anti-glycoprotein antibodies, particularly with anti-GPIIb/IIIa complex. Persistence of these antibodies sometimes leads to acquired auto-immune thrombopathy., Exegesis: We report the case of a woman treated by splenectomy for auto-immune thrombocytopenic purpura, who developed 5 years later an ecchymotic syndrome despite normal platelet count. High bleeding time and platelet aggregation defect in vitro were evidenced. Following the initial thrombocytopenia, anti-glycoproteins GPIIb/IIIa with lupus anticoagulant and benign monoclonal gammapathy were noticed. Platelet controls showed that hypoaggregant activity was secondary to the persistence of anti-GPIIb/IIa antibodies., Conclusion: This acquired auto-immune thrombopathy simulating Glanzmann's thrombasthenia was secondary to the persistence of platelet anti-glycoproteins GPIIb/IIIa.
- Published
- 1998
- Full Text
- View/download PDF
247. [Gorlin-Goltz syndrome with thyroid nodule].
- Author
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Disdier P, Lagier JP, Henry JF, de Micco C, and Weiller PJ
- Subjects
- Adult, Humans, Male, Thyroid Gland pathology, Thyroid Gland surgery, Thyroid Nodule pathology, Thyroid Nodule surgery, Basal Cell Nevus Syndrome complications, Thyroid Nodule complications
- Published
- 1998
248. Migraine and coeliac disease.
- Author
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Serratrice J, Disdier P, de Roux C, Christides C, and Weiller PJ
- Subjects
- Celiac Disease diet therapy, Child, Glutens administration & dosage, Humans, Male, Middle Aged, Celiac Disease complications, Migraine with Aura complications
- Abstract
The pathophysiology of migraine remains unclear. To incriminate a comorbid factor is always hypothetical, even if suppression of this factor appears to prevent the migrainous attacks. In our patient, treatment of coeliac disease coincided with total disappearance of severe migraine attacks. Moreover, the coeliac disease was first revealed during the evaluation of a migraine with aura.
- Published
- 1998
- Full Text
- View/download PDF
249. Inflammatory process complicating giant hemangioma of the liver: report of three cases.
- Author
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Pol B, Disdier P, Le Treut YP, Campan P, Hardwigsen J, and Weiller PJ
- Subjects
- Adult, Female, Hemangioma, Cavernous diagnosis, Hemangioma, Cavernous surgery, Hepatitis pathology, Humans, Liver Neoplasms diagnosis, Liver Neoplasms surgery, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, X-Ray Computed, Hemangioma, Cavernous complications, Hepatitis etiology, Liver Neoplasms complications
- Abstract
Three cases of giant hemangioma of the liver associated with clinical and laboratory signs of inflammatory process, including low-grade fever, weight loss, abdominal pain, accelerated erythrocyte sedimentation rate, anemia, thrombocytosis, and increased fibrinogen level with normal white blood cell count are described. One patient presented with slight cholestatic jaundice because of tumor-related bile duct compression, but the other two patients had normal liver function tests, except for a slight increase in gammaglutamyl transferase. Clinical and laboratory abnormalities disappeared after surgical excision. Inflammatory manifestations have rarely been reported during giant liver hemangioma. Intratumoral inflammation necrosis or bleeding could explain the symptoms but histological signs of inflammation were not detected in two of three surgical specimens. The release of immune mediators by liver endothelial cells lining the hemangioma is an alternative explanation. The incidence of inflammatory process complicating giant hemangioma is probably underestimated because our three cases were observed within a span of only 3 years., (Copyright 1998 W.B. Saunders Company.)
- Published
- 1998
- Full Text
- View/download PDF
250. [Antiphospholipid antibodies syndrome].
- Author
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Disdier P and Weiller PJ
- Subjects
- Antibodies, Antiphospholipid analysis, Humans, Antiphospholipid Syndrome complications, Antiphospholipid Syndrome diagnosis, Antiphospholipid Syndrome therapy
- Abstract
Antiphospholipid syndrome is characterized by thromboses, fetal losses and antiphospholipid antibodies. This group of antibodies includes lupus anticoagulant, false positive syphilitic reaction, anionic (such as anticardiolipin) and neutral phospholipids antibodies, and anti-phospholipid/cofactors antibodies (such as anti-beta 2-glycoprotein 1). Dominant manifestations are recurrent thrombophlebitis and pulmonary embolism, arterial occlusive disease of young people, obstetrical complications such as fetal losses, livedo, and thrombocytopenia. Warfarin is presently the main treatment.
- Published
- 1998
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