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216. NTIRE 2023 Image Shadow Removal Challenge Report

Author

Vasluianu, Florin-Alexandru, primary, Seizinger, Tim, additional, Timofte, Radu, additional, Cui, Shuhao, additional, Huang, Junshi, additional, Tian, Shuman, additional, Fan, Mingyuan, additional, Zhang, Jiaqi, additional, Zhu, Li, additional, Wei, Xiaoming, additional, Wei, Xiaolin, additional, Luo, Ziwei, additional, Gustafsson, Fredrik K., additional, Zhao, Zheng, additional, Sjölund, Jens, additional, Schön, Thomas B., additional, Dong, Xiaoyi, additional, Zhang, Xi Sheryl, additional, Li, Chenghua, additional, Leng, Cong, additional, Yeo, Woon-Ha, additional, Oh, Wang-Taek, additional, Lee, Yeo-Reum, additional, Ryu, Han-Cheol, additional, Luo, Jinting, additional, Jiang, Chengzhi, additional, Han, Mingyan, additional, Wu, Qi, additional, Lin, Wenjie, additional, Yu, Lei, additional, Li, Xinpeng, additional, Jiang, Ting, additional, Fan, Haoqiang, additional, Liu, Shuaicheng, additional, Xu, Shuning, additional, Song, Binbin, additional, Chen, Xiangyu, additional, Zhang, Shile, additional, Zhou, Jiantao, additional, Zhang, Zhao, additional, Zhao, Suiyi, additional, Zheng, Huan, additional, Gao, Yangcheng, additional, Wei, Yanyan, additional, Wang, Bo, additional, Ren, Jiahuan, additional, Luo, Yan, additional, Kondo, Yuki, additional, Miyata, Riku, additional, Yasue, Fuma, additional, Naruki, Taito, additional, Ukita, Norimichi, additional, Chang, Hua-En, additional, Yang, Hao-Hsiang, additional, Chen, Yi-Chung, additional, Chiang, Yuan-Chun, additional, Huang, Zhi-Kai, additional, Chen, Wei-Ting, additional, Chen, I-Hsiang, additional, Hsieh, Chia-Hsuan, additional, Kuo, Sy-Yen, additional, Xianwei, Li, additional, Fu, Huiyuan, additional, Liu, Chunlin, additional, Ma, Huadong, additional, Fu, Binglan, additional, He, Huiming, additional, Wang, Mengjia, additional, She, Wenxuan, additional, Liu, Yu, additional, Nathan, Sabari, additional, Kansal, Priya, additional, Zhang, Zhongjian, additional, Yang, Huabin, additional, Wang, Yan, additional, Zhang, Yanru, additional, Phutke, Shruti S., additional, Kulkarni, Ashutosh, additional, Khan, MD Raqib, additional, Murala, Subrahmanyam, additional, Vipparthi, Santosh Kumar, additional, Ye, Heng, additional, Liu, Zixi, additional, Yang, Xingyi, additional, Liu, Songhua, additional, Wu, Yinwei, additional, Jing, Yongcheng, additional, Yu, Qianhao, additional, Zheng, Naishan, additional, Huang, Jie, additional, Long, Yuhang, additional, Yao, Mingde, additional, Zhao, Feng, additional, Zhao, Bowen, additional, Ye, Nan, additional, Shen, Ning, additional, Cao, Yanpeng, additional, Xiong, Tong, additional, Xia, Weiran, additional, Li, Dingwen, additional, and Xia, Shuchen, additional

Published
2023
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220. Association of Tumor Cell Metabolic Subtype and Immune Response With the Clinical Course of Hepatocellular Carcinoma

Author

Wei, Xiaolin, primary, Michelakos, Theodoros, additional, He, Qian, additional, Wang, Xianxing, additional, Chen, Yu, additional, Kontos, Filippos, additional, Wang, Huaizhi, additional, Liu, Xiangde, additional, Liu, Hui, additional, Zheng, Wenjing, additional, Ferrone, Soldano, additional, Zhang, Yun, additional, Ferrone, Cristina R, additional, Li, Xiaowu, additional, and Cai, Lei, additional

Published
2023
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228. Evaluation of a package of risk-based pharmaceutical and lifestyle interventions in patients with hypertension and/or diabetes in rural China: A pragmatic cluster randomised controlled trial

Author

Wei, Xiaolin, Zhang, Zhitong, Chong, Marc K. C., Hicks, Joseph P., Gong, Weiwei, Zou, Guanyang, Zhong, Jieming, Walley, John D., Upshur, Ross E. G., and Yu, Min

Subjects
Rural population -- Care and treatment, Drug therapy -- Testing, Type 2 diabetes -- Care and treatment, Health counseling -- Testing, Hypertension -- Care and treatment, Biological sciences
Abstract

Background Primary prevention of cardiovascular disease (CVD) requires adequate control of hypertension and diabetes. We designed and implemented pharmaceutical and healthy lifestyle interventions for patients with diabetes and/or hypertension in rural primary care, and assessed their effectiveness at reducing severe CVD events. Methods and findings We used a pragmatic, parallel group, 2-arm, controlled, superiority, cluster trial design. We randomised 67 township hospitals in Zhejiang Province, China, to intervention (34) or control (33). A total of 31,326 participants were recruited, with 15,380 in the intervention arm and 15,946 in the control arm. Participants had no known CVD and were either patients with hypertension and a 10-year CVD risk of 20% or higher, or patients with type 2 diabetes regardless of their CVD risk. The intervention included prescription of a standardised package of medicines, individual advice on lifestyle change, and adherence support. Control was usual hypertension and diabetes care. In both arms, as usual in China, most outpatient drug costs were out of pocket. The primary outcome was severe CVD events, including coronary heart disease and stroke, during 36 months of follow-up, as recorded by the CVD surveillance system. The study was implemented between December 2013 and May 2017. A total of 13,385 (87%) and 14,745 (92%) participated in the intervention and control arms, respectively. Their mean age was 64 years, 51% were women, and 90% were farmers. Of all participants, 64% were diagnosed with hypertension with or without diabetes, and 36% were diagnosed with diabetes only. All township hospitals and participants completed the 36-month follow-up. At 36 months, there were 762 and 874 severe CVD events in the intervention and control arms, respectively, yielding a non-significant effect on CVD incidence rate (1.92 and 2.01 per 100 person-years, respectively; crude incidence rate ratio = 0.90 [95% CI: 0.74, 1.08; P = 0.259]). We observed significant, but small, differences in the change from baseline to follow-up for systolic blood pressure (-1.44 mm Hg [95% CI: -2.26, -0.62; P < 0.001]) and diastolic blood pressure (-1.29 mm Hg [95% CI: -1.77, -0.80; P < 0.001]) in the intervention arm compared to the control arm. Self-reported adherence to recommended medicines was significantly higher in the intervention arm compared with the control arm at 36 months. No safety concerns were identified. Main study limitations include all participants being informed about their high CVD risk at baseline, non-blinding of participants, and the relatively short follow-up period available for judging potential changes in rates of CVD events. Conclusions The comprehensive package of pharmaceutical and healthy lifestyle interventions did not reduce severe CVD events over 36 months. Improving health system factors such as universal coverage for the cost of essential medicines is required for successful risk-based CVD prevention programmes. Trial registration ISRCTN registry ISRCTN58988083., Author(s): Xiaolin Wei 1, Zhitong Zhang 1, Marc K. C. Chong 2, Joseph P. Hicks 3, Weiwei Gong 4, Guanyang Zou 5, Jieming Zhong 4, John D. Walley 3, Ross [...]

Published
2021
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232. Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells

Author

Southerland, Kevin W., primary, Xu, Yueyuan, additional, Peters, Derek T., additional, Wei, Xiaolin, additional, Lin, Xin, additional, Xiang, Yu, additional, Fei, Kaileen, additional, Olivere, Lindsey A., additional, Morowitz, Jeremy M., additional, Otto, James, additional, Dai, Qunsheng, additional, Kontos, Christopher D., additional, and Diao, Yarui, additional

Published
2023
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234. Protocol for a cluster randomised controlled trial to evaluate the effectiveness of digital health interventions in improving non-communicable disease management during the pandemic in rural Pakistan

Author

Wei, Xiaolin, primary, Khan, Nida, additional, Durrani, Hammad, additional, Muzaffar, Naila, additional, Haldane, Victoria, additional, Walley, John D, additional, Thorpe, Kevin, additional, Ge, Erjia, additional, Ge, Shiliang, additional, Dodd, Warren, additional, Wallace, James, additional, Aslanyan, Garry, additional, Laporte, Audrey, additional, and Khan, Muhammad Amir, additional

Published
2023
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235. Single-cell chromatin accessibility profiling reveals a self-renewing muscle satellite cell state

Author

Okafor, Arinze E., Lin, Xin, Situ, Chenghao, Wei, Xiaolin, Xiang, Yu, Wei, Xiuqing, Wu, Zhenguo, Diao, Yarui, Okafor, Arinze E., Lin, Xin, Situ, Chenghao, Wei, Xiaolin, Xiang, Yu, Wei, Xiuqing, Wu, Zhenguo, and Diao, Yarui

Abstract

A balance between self-renewal and differentiation is critical for the regenerative capacity of tissue-resident stem cells. In skeletal muscle, successful regeneration requires the orchestrated activation, proliferation, and differentiation of muscle satellite cells (MuSCs) that are normally quiescent. A subset of MuSCs undergoes self-renewal to replenish the stem cell pool, but the features that identify and define self-renewing MuSCs remain to be elucidated. Here, through single-cell chromatin accessibility analysis, we reveal the self-renewal versus differentiation trajectories of MuSCs over the course of regeneration in vivo. We identify Betaglycan as a unique marker of self-renewing MuSCs that can be purified and efficiently contributes to regeneration after transplantation. We also show that SMAD4 and downstream genes are genetically required for self-renewal in vivo by restricting differentiation. Our study unveils the identity and mechanisms of self-renewing MuSCs, while providing a key resource for comprehensive analysis of muscle regeneration.

Published
2023

248. Effectiveness of a Comprehensive Package Based on Electronic Medication Monitors at Improving Treatment Outcomes Among Tuberculosis Patients in Tibet: A Multi-Centre Randomised Controlled Trial

Author

Wei, Xiaolin, primary, Hicks, Joseph P., additional, Zhang, Zhitong, additional, Haldane, Victoria, additional, Pasang, Pande, additional, Li, Linhua, additional, Yin, Tingting, additional, Zhang, Bei, additional, Li, Yinlong, additional, Pan, Qiuyu, additional, Liu, Xiaoqiu, additional, Walley, John D., additional, and Hu, Jun, additional

Published
2023
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249. Effects of long-term ambient air pollution exposure on township-level pulmonary tuberculosis notification rates during 2005–2017 in Ningxia, China

Author

Popovic, Igor, primary, Soares Magalhães, Ricardo J., additional, Yang, Yurong, additional, Yang, Shukun, additional, Yang, Boyi, additional, Dong, Guanghui, additional, Wei, Xiaolin, additional, Fox, Greg J., additional, Hammer, Melanie S., additional, Martin, Randall V., additional, van Donkelaar, Aaron, additional, Ge, Erjia, additional, Marks, Guy B., additional, and Knibbs, Luke D., additional

Published
2023
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250. Large Scale Visual Food Recognition

Author

Min, Weiqing, primary, Wang, Zhiling, additional, Liu, Yuxin, additional, Luo, Mengjiang, additional, Kang, Liping, additional, Wei, Xiaoming, additional, Wei, Xiaolin, additional, and Jiang, Shuqiang, additional

Published
2023
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