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2,735 results on '"Wang, Q. Jane"'

208. Design, Synthesis, and Biological Evaluation of PKD Inhibitors

Author

George, Kara M., primary, Frantz, Marie-Céline, additional, Bravo-Altamirano, Karla, additional, LaValle, Courtney R., additional, Tandon, Manuj, additional, Leimgruber, Stephanie, additional, Sharlow, Elizabeth R., additional, Lazo, John S., additional, Wang, Q. Jane, additional, and Wipf, Peter, additional

Published
2011
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218. Abstract 2532: In vitro cytotoxicity, and pharmacokinetics, tissue distribution, and metabolism of the protein kinase D inhibitors, kb-NB142-70 and kb-NB184-43, in mice bearing human cancer xenografts

Author

Jianxia, Guo, primary, Parise, Robert A., additional, Beumer, Jan H., additional, Clausen, Dana M., additional, Egorin, Merrill J., additional, Lazo, John S., additional, Wipf, Peter, additional, Wang, Q. Jane, additional, and Eiseman, Julie L., additional

Published
2010
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238. On the Stribeck Curves for Lubricated Counterformal Contacts of Rough Surfaces.

Author

Dong Zhu, Jiaxu Wang, and Wang, Q. Jane

Subjects
ELASTOHYDRODYNAMIC lubrication, CURVES, ROUGH surfaces, FRICTION, GEOMETRY
Abstract

The "Stribeck curve" is a well-known concept, describing the frictional behavior of a lubricated inteiface during the transition from boundary and mixed lubrication up to full-film hydrodynamic!elastohydrodynamic lubrication. It can be found in nearly every tribology textbook!handbook and many articles and technical papers. However, the majority of the published Stribeck curves are only conceptual without real data from either experiments or numerical solutions. The limited number of published ones with real data is often incomplete, covering only a portion of the entire transition. This is because generating a complete Stribeck curve requires experimental or numerical results in an extremely wide range of operating conditions, which has been a great challenge. Also, numerically calculating a Stribeck cun'e requires a unified model with robust algorithms that is capable of handling the entire spectrum of lubrication status. In the present study, numerical solutions in counterformal contacts of rough surfaces are obtained by using the unified deterministic mixed elastohydrodynamic lubrication (EHL) model recently developed. Stribeck curves are plotted in a wide range of speed and lubricant film thickness based on the simulation results with various types of contact geometry using machined rough surfaces of different orientations. Surface flash temperature is also analyzed during the friction calculation considering the mutual dependence between friction and interfacial temperature. Obtained results show that in lubricated concentrated contacts, friction continuously decreases as speed and film thickness increase even in the full-film regime until extremely high speeds are reached. This is mainly due to the reduction of lubricant limiting shear stress caused by flash temperature rise. The results also reveal that contact ellipticity and roughness orientation have limited influence on frictional behaviors, especially in the full-film and boundary lubrication regimes. [ABSTRACT FROM AUTHOR]

Published
2015
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