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Additional file 1: Table 1. Associations between tertile of thyroid indicators and the risk of GDMin subjects with TPO Ab negativity. Table 2. Associations between extremely 10th/90thpercentile of thyroid indicators and the risk of GDM. Table 3. Associations between extremely 2.5th/97.5thpercentile thyroid indicators and the risk of GDM in subjects with TPO Abnegativity. Table 4. Associations between extremely 10th/90thpercentile thyroid indicators and the risk of GDM in subjects with TPO Abnegativity.

Additional file 1: Age- and sex-specific body mass index cutoff points for Chinese children and adolescents.

Additional file 2: Informed consent forms.

How to accurately and efficiently measure the profiles of the terrain on which agricultural machines operate has been an ongoing research topic. In this study, a surface profiling apparatus (profiler) was developed to measure agricultural terrain profiles along parallel tracks. The profiler is mainly composed of sensor frames, an RTK-GNSS system (Real Time Kinematics-Global Navigation Satellite Systems), laser sensors, an Inertial Measurement Unit (IMU) sensor and a data acquisition system. Along with a full description of how the terrain profiles were produced, a methodology to compensate for the tractor motion was included in the sensor data analysis. In field profiling validation, two trapezoidal bumps with known dimensions were used to assess the ability of the terrain profiler to reproduce the vertical profiles of the bumps, resulting in root mean square error (RMSE) of 3.6-4.7 mm and 4.5-5.1 mm with profiling speeds of 1.02 and 2.56 km/h, respectively. In addition, a validation test was also conducted on an asphalt road by profiling a flat road with the measuring wheels of the profiler rolling on the flat section but with the tractor wheels driving over a trapezoidal bump to excite the tractor pitch and roll motion. The measured profiles then also exhibited a flat road, which showed the ability of the profiler to remove the tractor motion from the profiling measurements.

Background: Considering the limitations of cisplatin in clinical application, there is ongoing research to fabricate new platinum-containing prodrug which are highly effective to tumor cells and have low toxicity to normal cells. Methods: In this study, a cyclodextrin-based supramolecular platinum prodrug that is 6,6’-ophenylenediseleno- bridged bis (β-cyclodextrin)s (CD) and its potassium tetrachloroplatinate(II) complex was reported. The cytotoxicity experiments were performed to evaluate the anticancer activities of supramolecular prodrug in vitro by means of MTT assay. The practical application of supramolecular prodrug in tumor treatment in vivo were evaluated using BALB/c nude mice model bearing Hela cancer cells. Results: Compared with commercial anticancer drug cisplatin, the resultant cyclodextrin-based platinum prodrug exhibited comparative anticancer effect but with much lower toxicity side effects in vitro and in vivo. Conclusion: The cyclodextrin-based supramolecular platinum prodrug displayed antitumor activity comparable to the commercial antitumor drug cisplatin but with lower side effects both in vitro and in vivo, implying that the two adjacent cyclodextrin cavities not merely act as desired solubilizer, but also endowed the prodrug with cell permeability through the interaction of cyclodextrin with phospholipids and cholesterol on cell membrane.

Objective: The purpose of this study was to evaluate serum zinc status of pregnant women in the China Adult Chronic Disease and Nutrition Surveillance (CACDNS) in 2015–2016. Methods: A total of 7147 apparently healthy pregnant women were randomly selected in 302 national monitoring sites. Information on age, race, residence region, education, pregnancy, and family income per annum was collected, and the concentration of serum zinc was determined. The evaluation of serum zinc status was further performed according to the recommendations by the International Zinc Nutrition Consultative Group (IZiNCG). Results: The median concentration of serum zinc was 858.9 μg/L with an interquartile range (IQR) of 712.9 μg/L and 1048.9 μg/L, while the overall prevalence of zinc deficiency was 3.5% with a 95% confidence interval (CI) of 3.0% and 3.9%. Serum zinc status of pregnant women changed greatly in the different categories, particular in pregnancy and family income per annum (p &lt, 0.05), but no significant difference was observed in the prevalence of zinc deficiency (p &gt, 0.05). Conclusions: The lower prevalence of zinc deficiency generally indicated a better zinc status for pregnant women in the CACDNS in 2015–2016. However, a well-designed evaluation system of zinc status for pregnant women should be continually optimized and improved by inducing more parameters such as biochemical, dietary, or functional indicators.

Additional file 1. Adverse events.