201. Traditional Chinese medicine for mild cognitive impairment:a protocol for systematic review and network meta analysis
- Author
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Wang, Hai-yan, Yu, Hai-yang, Song, kai, Xiong, Fanjie, and Zhang, Hong
- Subjects
mental disorders ,Medicine and Health Sciences ,Life Sciences ,Social and Behavioral Sciences - Abstract
Mild cognitive impairment (MCI) is defined as a subjective and objective decline in cognition and function greater than expected for an individual’s age and education level, which neither meets the criteria for diagnosis as dementia nor is severe enough to interfere with activities of daily living (ADL). MCI represents a significant risk factor for the development of dementia and is the primary target for early detection and management of dementia.A review of studies from the United States, Europe, Asia, and Australia estimated the overall prevalence of MCI at 6%–12%,but prevalence increases with age with 25.2% in people ages 80–84 years.People with MCI are at higher risk of progressing to dementia than age-matched controls.In the United States,it was estimated that 6.08 million people had MCI or AD and by 2060 this number is projected to reach 15.0 million.A number of clinical trials have assessed the effificacy of the acetylcholinesterase inhibitors (AChEIs), including donepezil, rivastigmine, and galantamine for MCI with some evidence of an effect. However, meta-analyses of randomized controlled trials (RCTs) have found no signifificant improvements on the well-known cognitive measures, Mini-Mental State Examination (MMSE) and Alzheimer’s Disease Assessment Scale–cognitivesection (ADAS-cog), or reductions in conversion to dementia at 1–3 years. Moreover, in the AChEI groups, there were increased risks of adverse events, including diarrhea, nausea, vomiting, muscle spasms or leg cramps, insomnia, headache, and abnormal dreams. Systematic reviews and meta-analyses evaluating the efficacy of cholinesterase inhibitors for MCI treatment have concluded that there is no convincing evidence that cholinesterase inhibitors have an effect on cognitive test scores or the progression of MCI to Alzheimer’s disease . There is some evidence suggesting that nonpharmacological terventions such as Moxibustion, physical exercise, and acupuncture might be beneficial for patients with MCI. However, there is currently no established treatment method for MCI.
- Published
- 2022
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