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645 results on '"Wang, Dong-Dong"'

213. Characterization of Highly Pathogenic Avian Influenza H5N1 Viruses Isolated from Domestic Poultry in China.

Author

LAI, Cheng Cai, WANG, Ke Yu, CHEN, Rui, ZHANG, Ai Jun, GU, Hong Jing, YIN, Yan Bo, WANG, Dong Dong, LIU, Lin Lin, XING, Li, TONG, Yi Gang, MA, Zong Juan, YANG, Peng Hui, and WANG, Xi Liang

Subjects
AVIAN influenza, EPIDEMICS, PUBLIC health, DEATH rate, PHYLOGENY
Abstract

The highly pathogenic avian influenza (HPAI) H5N1 virus has caused several outbreaks in domestic poultry. Despite great efforts to control the spread of this virus, it continues to evolve and poses a substantial threat to public health because of a high mortality rate. In this study, we sequenced whole genomes of eight H5N1 avian influenza viruses isolated from domestic poultry in eastern China and compared them with those of typical influenza virus strains. Phylogenetic analyses showed that all eight genomes belonged to clade 2.3.2.1 and clade 7.2, the two main circulating clades in China. Viruses that clustered in clade 2.3.2.1 shared a high degree of homology with H5N1 isolates located in eastern Asian. Isolates that clustered in clade 7.2 were found to circulate throughout China, with an east-to-west density gradient. Pathogenicity studies in mice showed that these isolates replicate in the lungs, and clade 2.3.2.1 viruses exhibit a notably higher degree of virulence compared to clade 7.2 viruses. Our results contribute to the elucidation of the biological characterization and pathogenicity of HPAI H5N1 viruses. [ABSTRACT FROM AUTHOR]

Published
2017
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238. Hydrocarbon generation characteristics, reserving performance and preservation conditions of continental coal measure shale gas: A case study of Mid-Jurassic shale gas in the Yan’an Formation, Ordos Basin.

Author

Wang, Dong-dong, Shao, Long-yi, LI, Zhi-xue, LI, Ming-pei, Lv, Dawei, and Liu, Haiyan

Subjects
*HYDROCARBON manufacturing, *COAL mine maintenance, *GAS reservoirs, *BIOGENIC landforms, *MINERALOGY
Abstract

Shale gas in nonmarine facies has attracted less interest compared with the marine facies. The Ordos Basin is one of the Jurassic nonmarine continental coal basins in northern China. Several exploration wells have revealed the existence of shale gas resources in the Middle Jurassic Yan’an Formation in this basin. The Yan’an Formation is the coal-measures in this basin, dominated by an intercalation of siliciclasitcs and thick coals, and the shales were mainly developed in the fluvial, lacustrine and lacustrine delta environments. The shales are multi-inerlayered with sandstones and coals, and have an unstable horizontal distribution. characterized by a small thickness of individual layer (ranging between 0.1 m and 34.77 m), and large thickness of the total cumulative layers (up to 380 m). The shales have intermediate to high contents of total organic carbon (ranging from 0.24% to 5.82%) and low thermal evolution degree in an immature-mature stage. The gas is mainly of biogenic origin, with relatively small fraction of thermogenic origin. The mineralogy investigation revealed that the shale have a lower content of brittle minerals and a high content clay minerals. The pore types are dominated by dissolution pores, intergranular pores, intragranular holes and micro cracks, and few organic holes can be seen. The porosity and permeability are low, with significant reservoir heterogeneity. The gas content in this nonmarine shale is low, dominated by adsorption phase. The shale gas in this basin were generally/enclosed within the groundwater flow closure zones, where the groundwater salinity is relatively low. The development characteristics of the shale and shale gas were also controlled by the depositional facies, and the conditions for hydrocarbon generation, reservoir performance, and gas preservation, can be favorably developed in the lacustrine facies, followed by the lacustrine delta facies, while the conditions in the fluvial facies are relatively poor. Although the resource potential of shale gas in the nonmarine continental coal-measures is lower than that of the marine facies, the shale gas, coal, coalbed methane, and tight sandstone gas often coexist in the continental coal basins which may support a more prospect energy scenario. Therefore, comprehensive exploration and collaborative development of the shale gas, coalbed methane and tight sandstone gas in the continental basin may be an ideal way to synthetically utilize the continental coal-measure gases. [ABSTRACT FROM AUTHOR]

Published
2016
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247. Accelerated Separation of Uranium from Lanthanides (La, Ce, Sm) in LiCl-KCl Eutectic by Porous Aluminum Electrodes

Author

Wang, Dong-Dong, Liu, Ya-Lan, Jiang, Shi-Lin, Zhong, Yu-Ke, Han, Wei, Li, Mei, Wang, Lin, Chai, Zhi-Fang, and Shi, Wei-Qun

Abstract

In order to optimize the application of Al electrodes in pyrochemical reprocessing of spent nuclear fuel, the feasibility of porous Al electrodes to separate actinides-lanthanides (An-Ln) in LiCl-KCl eutectic melt was explored. The separation efficiencies and rates of U and lanthanides (La, Ce, Sm) on Al electrodes with regular and irregular and without pores were compared. U was selectively recovered in the form of U-Al alloys by controlling the potential (−1.2 V) on both Al rod and porous Al electrodes. X-ray diffraction (XRD) and scanning electron microscopy (SEM)-energy dispersive spectroscopy (EDS) showed that the obtained granular alloys were mainly Al3U and Al4U, and inductive coupled plasma optical emission spectrometry (ICP-OES) indicated that there was almost no Ln in the electrolysis products. Positively, the required separation time was greatly shortened, and the separation rate was effectively improved when porous Al electrodes were used. In addition, the Al honeycomb electrode with regular pores has better kinetic performance compared with Al foam electrodes with irregular pores. The results indicate that the specially designed porous Al electrodes may have a good application prospect for the separation of An-Ln in the pyrochemical reprocessing of spent nuclear fuel.

Published
2023
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248. (±)-Salvicatone A: A Pair of C27-Meroterpenoid Enantiomers with Skeletons from the Roots and Rhizomes of Salvia castaneaDiels f. tomentosaStib

Author

Wang, Dong-Dong, Zhang, Rui, Tang, Lian-Yu, Long, Guo-Qing, Yan, Hui, Yang, Yong-Cheng, Guo, Zi-Feng, Zheng, Ying-Ying, Wang, Yong, Jia, Jing-Ming, and Wang, An-Hua

Abstract

(±)-Salvicatone A (1), a C27-meroterpenoid featuring a unique 6/6/6/6/6-pentacyclic carbon skeleton with a 7,8,8a,9,10,10a-hexahydropyren-1 (6H)-one motif, was isolated from the roots and rhizomes of Salvia castaneaDiels f. tomentosaStib. Its structure was characterized by comprehensive spectroscopic analyses along with computer-assisted structure elucidation, including ACD/structure elucidator and quantum chemical calculations with 1H/13C NMR and electronic circular dichroism. Biogenetically, compound 1was constructed from decarboxylation following [4 + 2] Diels–Alder cycloaddition reaction between caffeic acid and miltirone analogue. Bioassays showed that (−)-1and (+)-1inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophage cells with an IC50value of 6.48 ± 1.25 and 15.76 ± 5.55 μM, respectively. The structure-based virtual screening based on the pharmacophores in ePharmaLib, as well as the molecular docking and molecular dynamics simulations study, implied that (−)-1and (+)-1may potentially bind to retinoic acid receptor-related orphan receptor C to exert anti-inflammatory activities.

Published
2023
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