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'Jixiu' is a new early ripening pear variety bred by 'Jimi' × 'Xinhang', and its fruit quality is excellent. It has performed well in central and southern Hebei. This paper introduces its botanical characteristics, growth phenology, growth and fruiting habits, pollination characteristics and disease resistance in central and southern Hebei. A set of suitable cultivation techniques for Jixiu pear were summarized, including pruning, fruit thinning and bagging, water and fertilizer management, pest and disease control and so on, which provided theoretical support for the popularization and demonstration of this new variety.

Additional file 4. Simulation Class Design Scenario Script of Clinical Research 1 (ARandomized Controlled Trial Simulation).

Additional file 2. List of excluded studies. 176 studies were excluded after reviewing the full texts. Detailed information of these articles are shown.

Additional file 1. Search Strategy. Search strategy used in the eight databases.

Additional file 3. Quality Assessment of 10 RCTs. 10 RCTs included in the systematic review were assessed for literature quality using the Risk-of-bias Tool 1.0. a: Risk of bias graph: authors' judgements’ about each risk of bias item presented as percentages. b: Risk of bias summary: authors' judgements about each risk of bias item.

Additional file 5. Simulation Class Design Scenario Script of Clinical Research 2 (ACross-sectional Study Simulation)

Additional file 8. Results of Meta-analysis of Laboratory parameters. Results of Meta-analysis of WBC, neutrophiles, lymphocytes, platelets, CRP, IL-6, TNF-α, D-dimer, fibrinogen and ferritin in day 0–4 or day 5–8. a. Forest plot of WBC (day5–8): Std. Mean Difference (95% CI) and pooled estimates. b. Forest plot of neutrophils (day5–8): Std. Mean Difference (95% CI) and pooled estimates. c. Forest plot of lymphocytes (day5–8): Std. Mean Difference (95% CI) and pooled estimates. d. Forest plot of PLT (day0–4): Std. Mean Difference (95% CI) and pooled estimates. e. Forest plot of PLT (day5-8): Std. Mean Difference (95% CI) and pooled estimates. f. Forest plot of CRP (day0–4): Std. Mean Difference (95% CI) and pooled estimates. g. Forest plot of CRP (day5–8): Std. Mean Difference (95% CI) and pooled estimates. h. Forest plot of IL-6 (day5–8): Std. Mean Difference (95% CI) and pooled estimates. I. Forest plot of TNF-α (day5–8): Std. Mean Difference (95% CI) and pooled estimates. j. Forest plot of D-dimer (day0–4): Std. Mean Difference (95% CI) and pooled estimates. k. Forest plot of D-dimer (day5–8): Std. Mean Difference (95% CI) and pooled estimates. l. Forest plot of fibrinogen (day0–4): Std. Mean Difference (95% CI) and pooled estimates. m. Forest plot of fibrinogen (day5–8): Std. Mean Difference (95% CI) and pooled estimates. n. Forest plot of ferritin (day0–4): Std. Mean Difference (95% CI) and pooled estimates. o. Forest plot of ferritin (day5–8): Std. Mean Difference (95% CI) and pooled estimates.

Additional file 7. Serious Adverse Events. All serious adverse events reported in involved studies between experimental and control groups.

Additional file 3. Supplementary Figures and Tables.

Additional file 2. Expert Consultation Forms for the Syllabus for Clinical Research Courses.

Additional file 4. Quality Assessment of 7 NRCTs. 7 NRCTs included in the systematic review were assessed for literature quality using the MINORS instrument.

Additional file 1. Questionnaire on medical students’ cognition of clinical trials and scenario simulation teaching.