Search

Your search keyword '"W, Tan"' showing total 6,838 results
Start Over Author "W, Tan"
6,838 results on '"W, Tan"'

203. Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor Kinase Fusion–Positive Lung Cancers

Author

Alexander Drilon, Daniel S. W. Tan, Ulrik N. Lassen, Serge Leyvraz, Yongmei Liu, Jyoti D. Patel, Lee Rosen, Benjamin Solomon, Ricarda Norenberg, Laura Dima, Nicoletta Brega, Lin Shen, Victor Moreno, Shivaani Kummar, and Jessica J. Lin

Subjects
Adult, Male, Cancer Research, Lung Neoplasms, Middle Aged, Pyrimidines, Treatment Outcome, Oncology, Humans, Pyrazoles, Female, Gene Fusion, Protein Kinases, Aged
Abstract

PURPOSE Larotrectinib is a highly selective and CNS-active tropomyosin receptor kinase (TRK) inhibitor that has demonstrated efficacy across TRK fusion–positive cancers, regardless of the tumor type. The aim of this study was to assess the efficacy and safety of larotrectinib in patients with TRK fusion–positive lung cancers. MATERIALS AND METHODS Data from two global, multicenter, registrational clinical trials of patients treated with larotrectinib were analyzed: a phase II adult and young adult basket trial ( NCT02576431 ) and a phase I adult trial ( NCT02122913 ). The primary end point was objective response rate (ORR). RESULTS By July 20, 2020, 20 patients with TRK fusion–positive lung cancer had been treated. The ORR by investigator assessment among 15 evaluable patients was 73% (95% CI, 45 to 92); one (7%) patient had a complete response, 10 (67%) had a partial response, three (20%) had stable disease, and one (7%) had progressive disease as best response. The median duration of response, progression-free survival, and overall survival were 33.9 months (95% CI, 5.6 to 33.9), 35.4 months (95% CI, 5.3 to 35.4), and 40.7 months (95% CI, 17.2 to not estimable), respectively. Among patients with baseline CNS metastases, the ORR was 63% (95% CI, 25 to 91). Adverse events were mainly grade 1 or 2. CONCLUSION Larotrectinib is highly active with rapid and durable responses, extended survival benefit, and a favorable long-term safety profile in patients with advanced lung cancer harboring NTRK gene fusions, including those with CNS metastases. These findings support routine testing for NTRK fusions in patients with lung cancer.

Published
2022
Full Text
View/download PDF

204. Long-Term Efficacy and Safety of Entrectinib in

Author

Alexander, Drilon, Chao-Hua, Chiu, Yun, Fan, Byoung Chul, Cho, Shun, Lu, Myung-Ju, Ahn, Matthew G, Krebs, Stephen V, Liu, Thomas, John, Gregory A, Otterson, Daniel S W, Tan, Tejas, Patil, Rafal, Dziadziuszko, Erminia, Massarelli, Takashi, Seto, Robert C, Doebele, Bethany, Pitcher, Nino, Kurtsikidze, Sebastian, Heinzmann, and Salvatore, Siena

Abstract

Entrectinib is an approved tyrosine kinase inhibitor (TKI) forAdults withThe efficacy-assessable population comprised 168 ROS1 TKI-naïve patients. The median survival follow-up was 29.1 months (interquartile range, 21.8-35.9). The ORR was 68% (95% confidence interval [CI]: 60.2-74.8); the median DoR was 20.5 months. The median progression-free survival (PFS) was 15.7 months and the median OS was 47.8 months. In the 25 patients with measurable baseline CNS metastases, the intracranial ORR was 80% (95% CI: 59.3-93.2), median intracranial DoR was 12.9 months, and median intracranial PFS was 8.8 months. Among 18 patients with CNS-only progression on previous crizotinib treatment, two achieved a partial response (11%) and four had stable disease (22%). In seven patients with measurable CNS disease from this cohort, the intracranial ORR was 14% (1 partial response).Entrectinib is active and achieves prolonged survival in ROS1 TKI-naïve patients with

Published
2022

205. Observation of the π2σ2 -bond linear-chain molecular structure in C16

Author

J. X. Han, Y. Liu, Y. L. Ye, J. L. Lou, X. F. Yang, T. Baba, M. Kimura, B. Yang, Z. H. Li, Q. T. Li, J. Y. Xu, Y. C. Ge, H. Hua, Z. H. Yang, J. S. Wang, Y. Y. Yang, P. Ma, Z. Bai, Q. Hu, W. Liu, K. Ma, L. C. Tao, Y. Jiang, L. Y. Hu, H. L. Zang, J. Feng, H. Y. Wu, S. W. Bai, G. Li, H. Z. Yu, S. W. Huang, Z. Q. Chen, X. H. Sun, J. J. Li, Z. W. Tan, Z. H. Gao, F. F. Duan, J. H. Tan, S. Q. Sun, and Y. S. Song

Published
2022
Full Text
View/download PDF

208. 747 THE DIAGNOSIS AND MANAGEMENT OF HYPERKALAEMIA IN MEDICAL AND ELDERLY CARE INPATIENTS AT A DISTRICT GENERAL HOSPITAL

Author

C Broadhurst, K Thompson, and W Tan

Subjects
Aging, General Medicine, Geriatrics and Gerontology
Abstract

Introduction Severe hyperkalaemia is a dangerous and potentially life-threatening condition. Despite this knowledge, the incidence of hyperkalaemia in hospital inpatients remains high. On review of the acute management of hyperkalaemia at Croydon University Hospital, only 50% of medical and elderly care inpatients were managed correctly in line with hospital guidelines, and 50% of surveyed doctors did not feel confident managing acute hyperkalaemia—highlighting an urgent requirement for improvement. The project objectives were to improve management in line with hospital guidelines, overall prescription accuracy and the confidence of junior doctors in managing acute hyperkalaemia. Methods Two PDSA cycles; cycle one involved teaching sessions to doctors and the creation and circulation of information posters. Cycle two involved the development and implementation of a new electronic order prescription set for the management of acute hyperkalaemia. Results Post-intervention results showed an improvement in the correct management of hyperkalaemia from 50% to 80%. Prescription accuracy improved from 90% to 100%. Doctors reported an improvement in their overall confidence from 50% to 64%. Sub-group analysis identified no post-intervention improvement in the correct management of hyperkalaemia in care of the elderly (COTE, >80 years) patients. COTE patients were also less likely to be managed correctly (45% vs 57%) and to have accurate prescriptions (71% vs 100%). However, prescription accuracy did improve in the COTE group (50% to 100%). Conclusion This project achieved its initial objectives. However, COTE patients were less likely to be managed correctly. This may be secondary to being more complex patients, having multiple co-morbidities or significant polypharmacy, which may further contribute to hyperkalaemia. Doctors may feel less confident suspending or modifying medications in these cases and seek input from specialist teams prior to doing so. Future interventions will focus on delivering teaching sessions on hyperkalaemia in complex cases to improve confidence and understanding.

Published
2022
Full Text
View/download PDF

209. Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice

Author

Veluchamy A. Barathi, Jia Lin Kwan, Queenie S. W. Tan, Sung Rhan Weon, Li Fong Seet, Liang Kee Goh, Eranga N. Vithana, and Roger W. Beuerman

Subjects
Medicine, Pathology, RB1-214
Abstract

SUMMARY Myopia is a huge public health problem worldwide, reaching the highest incidence in Asia. Identification of susceptible genes is crucial for understanding the biological basis of myopia. In this paper, we have identified and characterized a functional myopia-associated gene using a specific mouse-knockout model. Mice lacking the muscarinic cholinergic receptor gene (M2; also known as Chrm2) were less susceptible to lens-induced myopia compared with wild-type mice, which showed significantly increased axial length and vitreous chamber depth when undergoing experimental induction of myopia. The key findings of this present study are that the sclera of M2 mutant mice has higher expression of collagen type I and lower expression of collagen type V than do wild-type mice and mice that are mutant for other muscarinic subtypes, and, therefore, M2 mutant mice were resistant to the development of experimental myopia. Pharmacological blockade of M2 muscarinic receptor proteins retarded myopia progression in the mouse. These results suggest for the first time a role of M2 in growth-related changes in extracellular matrix genes during myopia development in a mammalian model. M2 receptor antagonists might thus provide a targeted therapeutic approach to the management of this refractive error.

Published
2013
Full Text
View/download PDF

211. Outcomes of Iliac Crest Bone Marrow Aspirate Injection for the Treatment of Recalcitrant Non- Insertional Achilles Tendinitis

Author

Paul G. Talusan MD, Eric J. Dein BS, Eric W. Tan MD, Talal A. Zahoor MBBS, Guy Friedman, and Lew C. Schon MD

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Sports Introduction/Purpose: Non-insertional Achilles tendinitis is a common cause of posterior ankle and heel pain in active and sedentary patients. Though the majority of patients respond to first-line non-operative management including activity modification, immobilization, orthotics, and physical therapy with tendon stretching, there is no consensus for patients that fail these treatments. We evaluate the role of iliac crest bone marrow aspirate concentrate (BMAC) as a safe and effective treatment option for recalcitrant cases. Methods: A retrospective chart review was conducted of patients with greater than 12 months of non-insertional Achilles tendinitis symptoms despite appropriate conservative treatment. Each patient had BMA harvested from the iliac crest, concentrated by centrifugation, and then injected into the Achilles tendon. Symptoms were assessed using the Visual Analogue Scale (VAS) pain score, collected at the preoperative office visit and at 6 weeks, 12 weeks, and 24 weeks after the procedure. Co- morbidities, concurrent procedures, and complications were also recorded. Results: A total of 21 patients (22 feet) were treated with iliac crest BMA concentrate injections. Preoperatively, the average VAS pain score was 6.8 (SD 2.0). Postoperatively, the average VAS was 4.0 (SD 2.5) at 6 weeks, 2.7 (SD 2.1) at 12 weeks, and 2.2 (SD 2.1) at 24 weeks. At 24 weeks postoperatively, there was a statistically significant decrease VAS score from baseline (p < 0.001), with a mean decrease by 4.6 (SD 3.1). There were no adverse effects reported at the surgical site or donor site morbidity at the iliac crest such as wound infection, hematoma, or persistent pain. Conclusion: Iliac crest BMAC appears to be a safe, effective, and potentially lasting treatment option for patients with intractable, non-insertional Achilles tendinitis. Patients demonstrated a statistically significant decrease in VAS pain score postoperatively with no complications at the donor or injection site.

Published
2016
Full Text
View/download PDF

212. Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates.

Author

Sitara S R Ajjampur, Chin Wen Png, Wan Ni Chia, Yongliang Zhang, and Kevin S W Tan

Subjects
Medicine, Science
Abstract

Blastocystis spp. are widely prevalent extra cellular, non-motile anerobic protists that inhabit the gastrointestinal tract. Although Blastocystis spp. have been associated with gastrointestinal symptoms, irritable bowel syndrome and urticaria, their clinical significance has remained controversial. We established an ex vivo mouse explant model to characterize adhesion in the context of tissue architecture and presence of the mucin layer. Using confocal microscopy with tissue whole mounts and two axenic isolates of Blastocystis spp., subtype 7 with notable differences in adhesion to intestinal epithelial cells (IEC), isolate B (ST7-B) and isolate H (more adhesive, ST7-H), we showed that adhesion is both isolate dependent and tissue trophic. The more adhesive isolate, ST7-H was found to bind preferentially to the colon tissue than caecum and terminal ileum. Both isolates were also found to have mucinolytic effects. We then adapted a DSS colitis mouse model as a susceptible model to study colonization and acute infection by intra-caecal inoculation of trophic Blastocystis spp.cells. We found that the more adhesive isolate ST7-H was also a better colonizer with more mice shedding parasites and for a longer duration than ST7-B. Adhesion and colonization was also associated with increased virulence as ST7-H infected mice showed greater tissue damage than ST7-B. Both the ex vivo and in vivo models used in this study showed that Blastocystis spp. remain luminal and predominantly associated with mucin. This was further confirmed using colonic loop experiments. We were also successfully able to re-infect a second batch of mice with ST7-H isolates obtained from fecal cultures and demonstrated similar histopathological findings and tissue damage thereby coming closer to proving Koch's postulates for this parasite.

Published
2016
Full Text
View/download PDF

213. Ocelot (Leopardus pardalis) Density in Central Amazonia.

Author

Daniel Gomes da Rocha, Rahel Sollmann, Emiliano Esterci Ramalho, Renata Ilha, and Cedric K W Tan

Subjects
Medicine, Science
Abstract

Ocelots (Leopardus pardalis) are presumed to be the most abundant of the wild cats throughout their distribution range and to play an important role in the dynamics of sympatric small-felid populations. However, ocelot ecological information is limited, particularly for the Amazon. We conducted three camera-trap surveys during three consecutive dry seasons to estimate ocelot density in Amanã Reserve, Central Amazonia, Brazil. We implemented a spatial capture-recapture (SCR) model that shared detection parameters among surveys. A total effort of 7020 camera-trap days resulted in 93 independent ocelot records. The estimate of ocelot density in Amanã Reserve (24.84 ± SE 6.27 ocelots per 100 km2) was lower than at other sites in the Amazon and also lower than that expected from a correlation of density with latitude and rainfall. We also discuss the importance of using common parameters for survey scenarios with low recapture rates. This is the first density estimate for ocelots in the Brazilian Amazon, which is an important stronghold for the species.

Published
2016
Full Text
View/download PDF

214. Coronary ostial eccentricity in severe aortic stenosis: Guidance for BASILICA transcatheter leaflet laceration

Author

Mark Reisman, Christopher Rumer, Janarthanan Sathananthan, James M. McCabe, Christina W. Tan, Ran Kornowski, Gabriel S. Aldea, Sam Radhakrishnan, Nicolo Piazza, Philipp Blanke, Creighton W. Don, Ikki Komatsu, Harindra C. Wijeysundera, Jonathon Leipsic, Danny Dvir, G. Burkhard Mackensen, John G. Webb, Dmitry Levin, and Mario Ramos

Subjects
Male, medicine.medical_specialty, Computed Tomography Angiography, media_common.quotation_subject, medicine.medical_treatment, 030204 cardiovascular system & hematology, Coronary Angiography, Prosthesis Design, Severity of Illness Index, 030218 nuclear medicine & medical imaging, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Left coronary artery, Valve replacement, Predictive Value of Tests, Risk Factors, Internal medicine, medicine.artery, Multidetector Computed Tomography, medicine, Humans, Radiology, Nuclear Medicine and imaging, Eccentricity (behavior), Aged, media_common, Bioprosthesis, business.industry, Coronary Stenosis, Aortic Valve Stenosis, medicine.disease, Coronary Vessels, Stenosis, Treatment Outcome, medicine.anatomical_structure, Aortic Valve, Heart Valve Prosthesis, Right coronary artery, cardiovascular system, Cardiology, Cusp (anatomy), Female, Cardiology and Cardiovascular Medicine, Coronary cusp, business, Artery
Abstract

Background Eccentricity of coronary ostial positions in relation to the aortic valve cusp may influence the target laceration location in BASILICA (Bioprosthetic or native Aortic Scallop Intentional Laceration to prevent Coronary Artery obstruction). Eccentricity of the coronary ostia in relation to coronary cusps of native and valve-in-valve transcatheter aortic valve replacement (TAVR) was not well described before. Methods A total of 121 pre-TAVR patients’ CT data (72 native valves TAVR and 49 bioprosthetic surgical valves TAVR) was included and coronary ostial eccentricity angles were measured and compared. Coronary ostial angles were measured between mid-cusp line to coronary ostium in CT perpendicular images. Results In the overall cohort, the right coronary artery (RCA) had an eccentric origin in the majority of cases, favoring the commissure between the right and the non coronary cusp (17.0°, IQR; 10–25). On the other hand, the left coronary artery (LCA) originated most commonly near center of the cusp position (0°, IQR; -8 -7.5) In comparison of native and bioprosthetic valves, RCA ostial angles were more eccentric in native valves (19.0°, IQR; 12–26) than in bioprosthetic valves (14.0°, IQR; 3–20) (p = 0.004). Whereas, LCA ostial angle has no significant differences between native valves (−2.0°, IQR;-7.75-5.75) and bioprosthetic valves (1°, IQR;-8-13), (p = 0.6). Conclusion RCA ostia often have an eccentric origin towards the non-coronary cusp, especially in native aortic valves, while LCA ostia commonly originate near the center of the cusp. This finding may contribute to better performance of BASILICA procedures.

Published
2020
Full Text
View/download PDF

215. Characterization of Transcriptome Expression: The Response of Isatis indigotica to Salt Stress

Author

J. Yang, F.-Q. Wang, L.-L. Wang, S.-L. Shi, H.-W. Tan, Xiaoqing Tang, and K.-C. Wang

Subjects
0106 biological sciences, 0301 basic medicine, Plant physiology, Sequence assembly, Plant Science, Biology, 01 natural sciences, Reverse transcriptase, Transcriptome, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Biochemistry, Biosynthesis, chemistry, KEGG, Secondary metabolism, Gene, 010606 plant biology & botany
Abstract

Isatis indigotica Fort. is extremely widely planted and used for the source of the traditional Chinese medicine Radix Isatidis (Ban-Lan-Gen), which had pharmacological activities such as anti-endotoxic, antibacterial, antinociceptive, anti-inflammatory and antipyretic. In the cultivation, salt stress could affect the yields of Radix Isatidis, and activate the secondary metabolism, eg. the contents of epigoitrin in root and indigo in leaf increased after a period of salt stress, which was possibly regulated by related genes. But in early salt stress, the molecular response of I. indigotica and expression of related genes are also worthy of our attention, which it helps us to more fully understand the molecular response mechanism of I. indigotica, so that we can make better use of “salt stress” to stimulate its secondary metabolism. To determine the molecular changes of I. indigotica in salt stress, the RNA-seq was carried out for the expression profile with NGS QC Toolkit (v2.3.2) software, the Illumina HiSeqTM 2000 in Biomarker Technologies Co., Ltd and ESTScan program. The de novo assembly resulted in 33109 unigenes from more than 18.71 Gb data. Of these, 28868 unigenes were annotated using KOG, KEGG, Nr, Nt, Swiss-Prot and TrEMBL databases. Then, 11829 simple sequence repeats were found in unigenes and 7725 primers were designed. After detecting the expression value, the edgeR package found 135 DEG, of those 48 were up-regulated and 87 were down-regulated. The expression pattern of genes that was validated by qPCR indicated that mitochondrial transcription termination factor, non-LTR retroelement reverse transcriptase and CYP79F1 which involved in the first step in biosynthesis of core short-chain aliphatic glucosinolates might play a vital role in coping with salt stress. Although one assembly of I. indigotica unigenes were obtained before, this study would provide more molecular data for further analysis, and facilitate studies on the functions of genes involved in the salt related signal pathways.

Published
2020
Full Text
View/download PDF

216. Oral health and salivary function in ulcerative colitis patients

Author

C X W Tan, Nanne K. H. de Boer, Henk S. Brand, Ariana Goldinova, Marjolijn Duijvestein, Gerd Bouma, Neurosurgery, Gastroenterology and Hepatology, Maxillofacial Surgery (VUmc), Oral Biochemistry, Oral and Maxillofacial Surgery / Oral Pathology, Gastroenterology and hepatology, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, and AII - Inflammatory diseases

Subjects
Adult, Male, medicine.medical_specialty, Saliva, Adolescent, dental, Oral Health, Oral health, Gastroenterology, Inflammatory bowel disease, MUC5B, Severity of Illness Index, Xerostomia, Salivary function, Salivary Glands, 03 medical and health sciences, oral, Young Adult, 0302 clinical medicine, inflammatory bowel disease, Internal medicine, medicine, Humans, Aged, saliva, business.industry, Original Articles, Middle Aged, medicine.disease, Ulcerative colitis, digestive system diseases, stomatognathic diseases, Cross-Sectional Studies, Oncology, 030220 oncology & carcinogenesis, Quality of Life, 030211 gastroenterology & hepatology, Colitis, Ulcerative, Female, Self Report, business, Salivation
Abstract

BACKGROUND: Although ulcerative colitis primarily involves the colon, extra-intestinal manifestations are common and oral and dental complaints are no exception.OBJECTIVE: This study aims at evaluating oral and dental health problems and salivary function and composition in ulcerative colitis patients and its correlation with disease activity.METHODS: Xerostomia Inventory score, (unstimulated/stimulated) salivary flow rates, salivary amylase and mucin/ Mucin 5B levels, self-reported oral and dental complaints, the oral health related quality of life, Simple Clinical Colitis Activity Index and inflammatory bowel disease-specific health related quality of life were determined.RESULTS: The cohort consisted of 51 ulcerative colitis patients. Hyposalivation was experienced by 16% of patients under resting conditions and 24% under chewing-stimulated conditions. Xerostomia was not correlated with salivary flow rates. Disease activity did not influence salivary amylase and Mucin 5B concentrations. The Xerostomia Inventory score was correlated with the Simple Clinical Colitis Activity Index (p = 0.042) and inflammatory bowel disease-specific health related quality of life (p = 0.001). Most reported oral health problems were halitosis (29%) and aphthae (28%). Frequently reported dental problems were cavities (35%) and gum problems (31%). Patients with active disease experienced significantly more oral and dental complaints. The number of oral problems was positively correlated with the Simple Clinical Colitis Activity Index (p = 0.045) and negatively correlated with the inflammatory bowel disease-specific health related quality of life (p = 0.005).CONCLUSION: The subjective feeling of a dry mouth (xerostomia) is related to disease activity and disease activity-associated quality of life in ulcerative colitis patients, whereas the objective saliva secretion rate is not. Oral and dental health problems are frequently observed in patients with ulcerative colitis, especially during active disease.

Published
2020
Full Text
View/download PDF

217. Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta‐analysis of randomized controlled trials

Author

Yi W Tan, Maria A. Lopez-Olivo, Theng W Foong, Andrea Yap, and Ambika Paramasivan

Subjects
Adult, Visual analogue scale, Analgesic, Placebo, Anesthesia, Spinal, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, 030202 anesthesiology, law, medicine, Humans, Pain Management, Dexmedetomidine, Adverse effect, Randomized Controlled Trials as Topic, Pain, Postoperative, business.industry, Anesthesiology and Pain Medicine, Anesthesia, Shivering, medicine.symptom, business, 030217 neurology & neurosurgery, Postoperative nausea and vomiting, medicine.drug
Abstract

Background and objective A systematic review and meta-analysis of randomized controlled trials (RCTs) was undertaken to evaluate the effect of intrathecal dexmedetomidine (DEX) on the duration of postoperative analgesia, postoperative pain scores and incidences of adverse effects. Databases and data treatment Database search was performed from inception until January 2019. All RCTs analysing acute postoperative pain characteristics after intrathecal DEX administration in adults undergoing spinal anaesthesia for elective surgery were included. The primary outcome was postoperative analgesic duration, defined as the time to first analgesic request. The secondary outcomes included pain scores at 6, 12 and 24 postoperative hours and rates of hypotension, bradycardia, shivering and postoperative nausea and vomiting. Results Twenty-four studies comprising a total of 1,460 patients were included. Postoperative analgesic duration was prolonged with intrathecal DEX compared to placebo, with a pooled mean difference (MD) of 191.3 min (95% CI 168.8-213.8). Patients who received intrathecal DEX reported lower Visual Analogue Scale scores at 24 postoperative hours compared with those patients receiving placebo, with a MD (95% CI) of -1.05 (-1.89 to -0.20, p = 0.02). There were no differences in the incidence of adverse effects, except for a lower rate of postoperative shivering in the intrathecal DEX group (pooled relative risk 0.58, 95% CI 0.34-0.98, p = 0.04). Conclusions Compared to placebo, intrathecal DEX prolonged postoperative analgesic duration, reduced 24-hr pain intensity and reduced the incidence of shivering without an increase in other adverse effects. Significance The analgesic role of intrathecal DEX is promising due to its ability to significantly increase postoperative analgesic duration when compared with placebo. Its usage can be considered for patients undergoing surgeries with significant postoperative pain, particularly those intolerant of systemic analgesia. However, the optimal dose for various surgeries as well as its long-term neurological effects warrants further studies.

Published
2020
Full Text
View/download PDF

218. Studies in Southeast Asian Melastoma (Melastomataceae), 4. Clarification of Melastoma crinitum in Southeast Asia and the reinstatement of Melastoma molle

Author

Louise Neo, Hugh T. W. Tan, and Khoon Meng Wong

Subjects
biology, Genus, Range (biology), Melastomataceae, Taxonomy (biology), Forestry, Plant Science, biology.organism_classification, Southeast asian, Eudicots, Nomenclature, Ecology, Evolution, Behavior and Systematics, Melastoma
Abstract

In the most recent revision of the genus Melastoma Linnaeus (1753: 389) across its entire distributional range, seven species were recognized for Peninsular Malaysia and Singapore (Meyer 2001). Our recent studies in Southeast Asian Melastoma have led us to re-examine some of the species defined in that account, including those recorded for Peninsular Malaysia and Singapore (Wong 2015, Wong 2016, Neo et al. 2017).

Published
2020
Full Text
View/download PDF

220. Latest developments on topical therapies in chronic rhinosinusitis

Author

Neil C.-W. Tan and Alkis J. Psaltis

Subjects
Budesonide, medicine.medical_specialty, Debridement, Chronic rhinosinusitis, business.industry, medicine.medical_treatment, Colloidal silver, Surgical access, Safety profile, Otorhinolaryngology, medicine, Surgery, Nasal administration, Intensive care medicine, business, Research setting, medicine.drug
Abstract

Purpose of review Topical therapies play an important role in the management of chronic rhinosinusitis (CRS). A detailed literature review was undertaken to appraise recent evidence surrounding current topical therapies and novel treatments used in the setting of recalcitrant CRS. Recent findings Effective sinus surgery aids in the delivery of topical therapies. Budesonide nasal rinses delivered by saline irrigation offer clinical and symptomatic improvements pre and postoperatively with a well-proven safety profile. Topical steroids may additionally offer direct antibacterial effects as per in-vitro testing. Topical antibiotics are not recommended in routine practice; however, they may be of benefit for short-term eradication therapy. Novel treatments are under keen investigation and include bacteriophage, colloidal silver and manuka honey. The evidence base for these treatments is not robust enough to recommend their routine use at present. Summary Topical steroids delivered in conjunction with saline nasal irrigation offer the best combination of treatments in CRS and should be considered a standard of care. Wide surgical access and aggressive surgical debridement of polyposis facilitates the delivery of steroid irrigations to sinonasal mucosa and is associated with improved long-term outcomes following endoscopic sinus surgery. The use of novel treatments remains within the research setting alone.

Published
2020
Full Text
View/download PDF

221. Visual design for a mobile pandemic map system for public health

Author

Astrid Kensinger, Janelle S. Ng, May O. Lwin, Karthikayen Jayasundar, Sheryl W. Tan, Wee Kim Wee School of Communication and Information, and School of Art, Design and Media

Subjects
Communication design, Disease surveillance, medicine.medical_specialty, business.industry, Computer science, Public health, Data management, Internet privacy, Communication [Social sciences], Usability, Crowdsourcing, Human-Computer Interaction, Philosophy, Mobile App Design, Artificial Intelligence, Mobile phone, Management system, medicine, business, Pandemics
Abstract

Incidence and prevalence rates of dengue have increased over the years, and the disease is quickly becoming cause for concern within the public health community. Globally, 128 countries and slightly under four billion people are at risk of contracting dengue. In Sri Lanka, more than half of dengue cases originate in Colombo, which in previous years, used a manual pen-and-paper data management system, which meant that it was not possible to obtain or provide up-to-date information about the severity and spread of dengue. In 2015, two versions of a mobile application called Mo-Buzz Dengue were developed and launched in Colombo, Sri Lanka in order to overcome the challenges of the traditional management system by capitalizing on the rising affordability and ubiquity of mobile phone technology. To keep up with the dynamic nature of disease outbreaks, real-time data need to be visualized in a manner which facilitates discerning and comprehending these patterns. Hence, we used health maps in Mo-Buzz to effectively present this information. The first version of Mo-Buzz was for public health inspectors (PHIs), digitized data management as well as provided educational materials. The second version of Mo-Buzz was a source of information for the general public, a crowdsourcing platform to provide information relating to dengue transmission, and for health authorities to alert users to dengue-specific developments in their area. This paper illustrates the design considerations of the Mo-Buzz disease surveillance system for the general public. A draft scaled-down version of the PHI system was used to obtain feedback and make incremental design enhancements. Additionally, similar health maps were evaluated in terms of capability and usability. These findings were applied to identify future enhancements to the health map of Mo-Buzz Dengue. Nanyang Technological University National Research Foundation (NRF) This research is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its International Research Centres in Singapore Funding Initiative and administered by the Interactive Digital Media Programme Office. We wish to acknowledge the funding support for this project from Nanyang Technological University under the Undergraduate Research Experience on Campus (URECA) programme.

Published
2020
Full Text
View/download PDF

223. Management of urethral atrophy after implantation of artificial urinary sphincter: what are the weaknesses?

Author

Ronny B W Tan and Nathaniel H Heah

Subjects
medicine.medical_specialty, Prosthesis-Related Infections, Urinary Incontinence, Stress, Urology, 030232 urology & nephrology, Urinary incontinence, Balloon, lcsh:RC870-923, Implant surgery, Prosthesis Implantation, tandem cuffs, Artificial urinary sphincter, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Patient satisfaction, Urethra, Urethral Diseases, medicine, Humans, Urethral Stricture, Invited Review, urethral atrophy, 030219 obstetrics & reproductive medicine, business.industry, General Medicine, artificial urinary sphincter, Urethral atrophy, lcsh:Diseases of the genitourinary system. Urology, Prosthesis Failure, Surgery, transcorporal cuffs, Cuff, Urinary Sphincter, Artificial, artificial urinary sphincter complications, Atrophy, medicine.symptom, business
Abstract

The use of artificial urinary sphincter (AUS) for the treatment of stress urinary incontinence has become more prevalent, especially in the “prostate-specific antigen (PSA)-era”, when more patients are treated for localized prostate cancer. The first widely accepted device was the AMS 800, but since then, other devices have also entered the market. While efficacy has increased with improvements in technology and technique, and patient satisfaction is high, AUS implantation still has inherent risks and complications of any implant surgery, in addition to the unique challenges of urethral complications that may be associated with the cuff. Furthermore, the unique nature of the AUS, with a control pump, reservoir, balloon cuff, and connecting tubing, means that mechanical complications can also arise from these individual parts. This article aims to present and summarize the current literature on the management of complications of AUS, especially urethral atrophy. We conducted a literature search on PubMed from January 1990 to December 2018 on AUS complications and their management. We review the various potential complications and their management. AUS complications are either mechanical or nonmechanical complications. Mechanical complications usually involve malfunction of the AUS. Nonmechanical complications include infection, urethral atrophy, cuff erosion, and stricture. Challenges exist especially in the management of urethral atrophy, with both tandem implants, transcorporal cuffs, and cuff downsizing all postulated as potential remedies. Although complications from AUS implants are not common, knowledge of the management of these issues are crucial to ensure care for patients with these implants. Further studies are needed to further evaluate these techniques.

Published
2020

226. Evaluating a Deep Learning Diabetic Retinopathy Grading System Developed on Mydriatic Retinal Images When Applied to Non-Mydriatic Community Screening

Author

Joan M. Nunez do Rio, Paul Nderitu, Christos Bergeles, Sobha Sivaprasad, Gavin S. W. Tan, and Rajiv Raman

Subjects
diabetic retinopathy, handheld non-mydriatic images, deep learning, Medicine, General Medicine
Abstract

Artificial Intelligence has showcased clear capabilities to automatically grade diabetic retinopathy (DR) on mydriatic retinal images captured by clinical experts on fixed table-top retinal cameras within hospital settings. However, in many low- and middle-income countries, screening for DR revolves around minimally trained field workers using handheld non-mydriatic cameras in community settings. This prospective study evaluated the diagnostic accuracy of a deep learning algorithm developed using mydriatic retinal images by the Singapore Eye Research Institute, commercially available as Zeiss VISUHEALTH-AI DR, on images captured by field workers on a Zeiss Visuscout® 100 non-mydriatic handheld camera from people with diabetes in a house-to-house cross-sectional study across 20 regions in India. A total of 20,489 patient eyes from 11,199 patients were used to evaluate algorithm performance in identifying referable DR, non-referable DR, and gradability. For each category, the algorithm achieved precision values of 29.60 (95% CI 27.40, 31.88), 92.56 (92.13, 92.97), and 58.58 (56.97, 60.19), recall values of 62.69 (59.17, 66.12), 85.65 (85.11, 86.18), and 65.06 (63.40, 66.69), and F-score values of 40.22 (38.25, 42.21), 88.97 (88.62, 89.31), and 61.65 (60.50, 62.80), respectively. Model performance reached 91.22 (90.79, 91.64) sensitivity and 65.06 (63.40, 66.69) specificity at detecting gradability and 72.08 (70.68, 73.46) sensitivity and 85.65 (85.11, 86.18) specificity for the detection of all referable eyes. Algorithm accuracy is dependent on the quality of acquired retinal images, and this is a major limiting step for its global implementation in community non-mydriatic DR screening using handheld cameras. This study highlights the need to develop and train deep learning-based screening tools in such conditions before implementation.

Published
2022
Full Text
View/download PDF

227. Search for Wγ resonances in proton-proton collisions at s=13 TeV using hadronic decays of Lorentz-boosted W bosons

Author

Tumasyan, A. Adam, W. Andrejkovic, J.W. Bergauer, T. Chatterjee, S. Dragicevic, M. Escalante Del Valle, A. Frühwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I. Pitters, F.M. Schieck, J. Schöfbeck, R. Spanring, M. Templ, S. Waltenberger, W. Wulz, C.-E. Chekhovsky, V. Litomin, A. Makarenko, V. Darwish, M.R. De Wolf, E.A. Janssen, X. Kello, T. Lelek, A. Rejeb Sfar, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E.S. D'Hondt, J. De Clercq, J. Delcourt, M. Lowette, S. Moortgat, S. Morton, A. Müller, D. Sahasransu, A.R. Tavernier, S. Van Doninck, W. Van Mulders, P. Beghin, D. Bilin, B. Clerbaux, B. De Lentdecker, G. Favart, L. Grebenyuk, A. Kalsi, A.K. Lee, K. Mahdavikhorrami, M. Makarenko, I. Moureaux, L. Pétré, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. Vannerom, D. Wezenbeek, L. Cornelis, T. Dobur, D. Gruchala, M. Mestdach, G. Niedziela, M. Roskas, C. Skovpen, K. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Bethani, A. Bruno, G. Bury, F. Caputo, C. David, P. Delaere, C. Donertas, I.S. Giammanco, A. Lemaitre, V. Mondal, K. Prisciandaro, J. Taliercio, A. Teklishyn, M. Vischia, P. Wertz, S. Wuyckens, S. Alves, G.A. Hensel, C. Moraes, A. Aldá Júnior, W.L. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E.M. Da Silveira, G.G. De Jesus Damiao, D. Fonseca De Souza, S. Matos Figueiredo, D. Mora Herrera, C. Mota Amarilo, K. Mundim, L. Nogima, H. Rebello Teles, P. Sanchez Rosas, L.J. Santoro, A. Silva Do Amaral, S.M. Sznajder, A. Thiel, M. Torres Da Silva De Araujo, F. Vilela Pereira, A. Bernardes, C.A. Calligaris, L. Fernandez Perez Tomei, T.R. Gregores, E.M. Lemos, D.S. Mercadante, P.G. Novaes, S.F. Padula, S.S. Aleksandrov, A. Antchev, G. Atanasov, I. Hadjiiska, R. Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Cheng, T. Fang, W. Guo, Q. Javaid, T. Mittal, M. Wang, H. Yuan, L. Ahmad, M. Bauer, G. Dozen, C. Hu, Z. Martins, J. Wang, Y. Yi, K. Chapon, E. Chen, G.M. Chen, H.S. Chen, M. Kapoor, A. Leggat, D. Liao, H. Liu, Z.-A. Sharma, R. Spiezia, A. Tao, J. Thomas-wilsker, J. Wang, J. Zhang, H. Zhang, S. Zhao, J. Agapitos, A. Ban, Y. Chen, C. Huang, Q. Levin, A. Li, Q. Lu, M. Lyu, X. Mao, Y. Qian, S.J. Wang, D. Wang, Q. Xiao, J. You, Z. Gao, X. Okawa, H. Xiao, M. Avila, C. Cabrera, A. Florez, C. Fraga, J. Sarkar, A. Segura Delgado, M.A. Jaramillo, J. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J.D. Salazar González, C.A. Vanegas Arbelaez, N. Giljanovic, D. Godinovic, N. Lelas, D. Puljak, I. Antunovic, Z. Kovac, M. Sculac, T. Brigljevic, V. Ferencek, D. Majumder, D. Roguljic, M. Starodumov, A. Susa, T. Attikis, A. Erodotou, E. Ioannou, A. Kole, G. Kolosova, M. Konstantinou, S. Mousa, J. Nicolaou, C. Ptochos, F. Razis, P.A. Rykaczewski, H. Saka, H. Finger, M. Kveton, A. Ayala, E. Carrera Jarrin, E. Abu Zeid, S. Elgammal, S. Salama, E. Mahmoud, M.A. Mohammed, Y. Bhowmik, S. Carvalho Antunes De Oliveira, A. Dewanjee, R.K. Ehataht, K. Kadastik, M. Pata, J. Raidal, M. Veelken, C. Eerola, P. Forthomme, L. Kirschenmann, H. Osterberg, K. Voutilainen, M. Brücken, E. Garcia, F. Havukainen, J. Karimäki, V. Kim, M.S. Kinnunen, R. Lampén, T. Lassila-Perini, K. Lehti, S. Lindén, T. Lotti, M. Siikonen, H. Tuominen, E. Tuominiemi, J. Luukka, P. Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J.L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. Hamel de Monchenault, G. Jarry, P. Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. Sahin, M.Ö. Savoy-Navarro, A. Titov, M. Yu, G.B. Ahuja, S. Beaudette, F. Bonanomi, M. Buchot Perraguin, A. Busson, P. Charlot, C. Davignon, O. Diab, B. Falmagne, G. Ghosh, S. Granier de Cassagnac, R. Hakimi, A. Kucher, I. Lobanov, A. Nguyen, M. Ochando, C. Paganini, P. Rembser, J. Salerno, R. Sauvan, J.B. Sirois, Y. Zabi, A. Zghiche, A. Agram, J.-L. Andrea, J. Apparu, D. Bloch, D. Bourgatte, G. Brom, J.-M. Chabert, E.C. Collard, C. Darej, D. Fontaine, J.-C. Goerlach, U. Grimault, C. Le Bihan, A.-C. Van Hove, P. Asilar, E. Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Carle, A. Chanon, N. Contardo, D. Depasse, P. El Mamouni, H. Fay, J. Gascon, S. Gouzevitch, M. Ille, B. Jain, S. Laktineh, I.B. Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. Shchablo, K. Torterotot, L. Touquet, G. Vander Donckt, M. Viret, S. Khvedelidze, A. Tsamalaidze, Z. Feld, L. Klein, K. Lipinski, M. Meuser, D. Pauls, A. Rauch, M.P. Teroerde, M. Eliseev, D. Erdmann, M. Fackeldey, P. Fischer, B. Hebbeker, T. Hoepfner, K. Ivone, F. Keller, H. Mastrolorenzo, L. Merschmeyer, M. Meyer, A. Mocellin, G. Mondal, S. Mukherjee, S. Noll, D. Novak, A. Pook, T. Pozdnyakov, A. Rath, Y. Reithler, H. Roemer, J. Schmidt, A. Schuler, S.C. Sharma, A. Wiedenbeck, S. Zaleski, S. Dziwok, C. Flügge, G. Haj Ahmad, W. Hlushchenko, O. Kress, T. Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. Stahl, A. Ziemons, T. Aarup Petersen, H. Aldaya Martin, M. Asmuss, P. Babounikau, I. Baxter, S. Behnke, O. Bermúdez Martínez, A. Bin Anuar, A.A. Borras, K. Botta, V. Brunner, D. Campbell, A. Cardini, A. Connor, P. Consuegra Rodríguez, S. Danilov, V. Defranchis, M.M. Didukh, L. Eckerlin, G. Eckstein, D. Estevez Banos, L.I. Gallo, E. Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. Harb, A. Jafari, A. Jomhari, N.Z. Jung, H. Kasem, A. Kasemann, M. Kaveh, H. Kleinwort, C. Knolle, J. Krücker, D. Lange, W. Lenz, T. Lidrych, J. Lipka, K. Lohmann, W. Madlener, T. Mankel, R. Melzer-Pellmann, I.-A. Metwally, J. Meyer, A.B. Meyer, M. Mnich, J. Mussgiller, A. Myronenko, V. Otarid, Y. Pérez Adán, D. Pitzl, D. Raspereza, A. Rübenach, J. Saggio, A. Saibel, A. Savitskyi, M. Scheurer, V. Schwanenberger, C. Singh, A. Sosa Ricardo, R.E. Tonon, N. Turkot, O. Vagnerini, A. Van De Klundert, M. Walsh, R. Walter, D. Wen, Y. Wichmann, K. Wissing, C. Wuchterl, S. Zlebcik, R. Aggleton, R. Bein, S. Benato, L. Benecke, A. De Leo, K. Dreyer, T. Eich, M. Feindt, F. Fröhlich, A. Garbers, C. Garutti, E. Gunnellini, P. Haller, J. Hinzmann, A. Karavdina, A. Kasieczka, G. Klanner, R. Kogler, R. Kutzner, V. Lange, J. Lange, T. Malara, A. Nigamova, A. Pena Rodriguez, K.J. Rieger, O. Schleper, P. Schröder, M. Schwandt, J. Schwarz, D. Sonneveld, J. Stadie, H. Steinbrück, G. Tews, A. Vormwald, B. Zoi, I. Bechtel, J. Berger, T. Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. Faltermann, N. Flöh, K. Giffels, M. Gosewisch, J.O. Gottmann, A. Hartmann, F. Heidecker, C. Husemann, U. Katkov, I. Keicher, P. Koppenhöfer, R. Maier, S. Metzler, M. Mitra, S. Müller, T. Neukum, M. Quast, G. Rabbertz, K. Rauser, J. Savoiu, D. Schäfer, D. Schnepf, M. Seith, D. Shvetsov, I. Simonis, H.J. Ulrich, R. Van Der Linden, J. Von Cube, R.F. Wassmer, M. Weber, M. Wieland, S. Wolf, R. Wozniewski, S. Wunsch, S. Anagnostou, G. Asenov, P. Daskalakis, G. Geralis, T. Kyriakis, A. Loukas, D. Stakia, A. Diamantopoulou, M. Karasavvas, D. Karathanasis, G. Kontaxakis, P. Koraka, C.K. Manousakis-katsikakis, A. Panagiotou, A. Papavergou, I. Saoulidou, N. Theofilatos, K. Tziaferi, E. Vellidis, K. Vourliotis, E. Bakas, G. Kousouris, K. Papakrivopoulos, I. Tsipolitis, G. Zacharopoulou, A. Evangelou, I. Foudas, C. Gianneios, P. Katsoulis, P. Kokkas, P. Manthos, N. Papadopoulos, I. Strologas, J. Csanad, M. Farkas, K. Gadallah, M.M.A. Lökös, S. Major, P. Mandal, K. Mehta, A. Pasztor, G. Rádl, A.J. Surányi, O. Veres, G.I. Bartók, M. Bencze, G. Hajdu, C. Horvath, D. Sikler, F. Veszpremi, V. Vesztergombi, G. Czellar, S. Karancsi, J. Molnar, J. Szillasi, Z. Teyssier, D. Raics, P. Trocsanyi, Z.L. Ujvari, B. Csorgo, T. Nemes, F. Novak, T. Choudhury, S. Komaragiri, J.R. Kumar, D. Panwar, L. Tiwari, P.C. Bahinipati, S. Dash, D. Kar, C. Mal, P. Mishra, T. Muraleedharan Nair Bindhu, V.K. Nayak, A. Saha, P. Sur, N. Swain, S.K. Bansal, S. Beri, S.B. Bhatnagar, V. Chaudhary, G. Chauhan, S. Dhingra, N. Gupta, R. Kaur, A. Kaur, S. Kumari, P. Meena, M. Sandeep, K. Singh, J.B. Virdi, A.K. Ahmed, A. Bhardwaj, A. Choudhary, B.C. Garg, R.B. Gola, M. Keshri, S. Kumar, A. Naimuddin, M. Priyanka, P. Ranjan, K. Shah, A. Bharti, M. Bhattacharya, R. Bhattacharya, S. Bhowmik, D. Dutta, S. Gomber, B. Maity, M. Nandan, S. Palit, P. Rout, P.K. Saha, G. Sahu, B. Sarkar, S. Sharan, M. Singh, B. Thakur, S. Behera, P.K. Behera, S.C. Kalbhor, P. Muhammad, A. Pradhan, R. Pujahari, P.R. Sikdar, A.K. Dutta, D. Jha, V. Kumar, V. Mishra, D.K. Naskar, K. Netrakanti, P.K. Pant, L.M. Shukla, P. Aziz, T. Dugad, S. Mohanty, G.B. Sarkar, U. Banerjee, S. Chudasama, R. Guchait, M. Karmakar, S. Kumar, S. Majumder, G. Mazumdar, K. Dube, S. Kansal, B. Pandey, S. Rane, A. Rastogi, A. Sharma, S. Bakhshiansohi, H. Zeinali, M. Chenarani, S. Etesami, S.M. Khakzad, M. Mohammadi Najafabadi, M. Felcini, M. Grunewald, M. Abbrescia, M. Aly, R. Aruta, C. Colaleo, A. Creanza, D. De Filippis, N. De Palma, M. Di Florio, A. Di Pilato, A. Elmetenawee, W. Fiore, L. Gelmi, A. Gul, M. Iaselli, G. Ince, M. Lezki, S. Maggi, G. Maggi, M. Margjeka, I. Mastrapasqua, V. Merlin, J.A. My, S. Nuzzo, S. Pellecchia, A. Pompili, A. Pugliese, G. Ranieri, A. Selvaggi, G. Silvestris, L. Simone, F.M. Venditti, R. Verwilligen, P. Abbiendi, G. Battilana, C. Bonacorsi, D. Borgonovi, L. Braibant-Giacomelli, S. Brigliadori, L. Campanini, R. Capiluppi, P. Castro, A. Cavallo, F.R. Ciocca, C. Cuffiani, M. Dallavalle, G.M. Diotalevi, T. Fabbri, F. Fanfani, A. Fontanesi, E. Giacomelli, P. Giommi, L. Grandi, C. Guiducci, L. Iemmi, F. Lo Meo, S. Marcellini, S. Masetti, G. Navarria, F.L. Perrotta, A. Primavera, F. Rossi, A.M. Rovelli, T. Siroli, G.P. Tosi, N. Albergo, S. Costa, S. Di Mattia, A. Potenza, R. Tricomi, A. Tuve, C. Barbagli, G. Cassese, A. Ceccarelli, R. Ciulli, V. Civinini, C. D'Alessandro, R. Fiori, F. Focardi, E. Latino, G. Lenzi, P. Lizzo, M. Meschini, M. Paoletti, S. Seidita, R. Sguazzoni, G. Viliani, L. Benussi, L. Bianco, S. Piccolo, D. Bozzo, M. Ferro, F. Mulargia, R. Robutti, E. Tosi, S. Benaglia, A. Brivio, F. Cetorelli, F. Ciriolo, V. De Guio, F. Dinardo, M.E. Dini, P. Gennai, S. Ghezzi, A. Govoni, P. Guzzi, L. Malberti, M. Malvezzi, S. Massironi, A. Menasce, D. Monti, F. Moroni, L. Paganoni, M. Pedrini, D. Ragazzi, S. Tabarelli de Fatis, T. Valsecchi, D. Zuolo, D. Buontempo, S. Carnevali, F. Cavallo, N. De Iorio, A. Fabozzi, F. Iorio, A.O.M. Lista, L. Meola, S. Paolucci, P. Rossi, B. Sciacca, C. Azzi, P. Bacchetta, N. Bisello, D. Bortignon, P. Bragagnolo, A. Carlin, R. Checchia, P. De Castro Manzano, P. Dorigo, T. Gasparini, F. Gasparini, U. Hoh, S.Y. Layer, L. Margoni, M. Meneguzzo, A.T. Presilla, M. Ronchese, P. Rossin, R. Simonetto, F. Strong, G. Tosi, M. Yarar, H. Zanetti, M. Zotto, P. Zucchetta, A. Zumerle, G. Aimè, C. Braghieri, A. Calzaferri, S. Fiorina, D. Montagna, P. Ratti, S.P. Re, V. Ressegotti, M. Riccardi, C. Salvini, P. Vai, I. Vitulo, P. Bilei, G.M. Ciangottini, D. Fanò, L. Lariccia, P. Mantovani, G. Mariani, V. Menichelli, M. Moscatelli, F. Piccinelli, A. Rossi, A. Santocchia, A. Spiga, D. Tedeschi, T. Azzurri, P. Bagliesi, G. Bertacchi, V. Bianchini, L. Boccali, T. Bossini, E. Castaldi, R. Ciocci, M.A. Dell'Orso, R. Di Domenico, M.R. Donato, S. Giassi, A. Grippo, M.T. Ligabue, F. Manca, E. Mandorli, G. Messineo, A. Palla, F. Parolia, S. Ramirez-Sanchez, G. Rizzi, A. Rolandi, G. Roy Chowdhury, S. Scribano, A. Shafiei, N. Spagnolo, P. Tenchini, R. Tonelli, G. Turini, N. Venturi, A. Verdini, P.G. Campana, M. Cavallari, F. Cipriani, M. Del Re, D. Di Marco, E. Diemoz, M. Longo, E. Meridiani, P. Organtini, G. Pandolfi, F. Paramatti, R. Quaranta, C. Rahatlou, S. Rovelli, C. Santanastasio, F. Soffi, L. Tramontano, R. Amapane, N. Arcidiacono, R. Argiro, S. Arneodo, M. Bartosik, N. Bellan, R. Bellora, A. Berenguer Antequera, J. Biino, C. Cappati, A. Cartiglia, N. Cometti, S. Costa, M. Covarelli, R. Demaria, N. Kiani, B. Legger, F. Mariotti, C. Maselli, S. Migliore, E. Monteil, E. Monteno, M. Obertino, M.M. Ortona, G. Pacher, L. Pastrone, N. Pelliccioni, M. Pinna Angioni, G.L. Ruspa, M. Salvatico, R. Shchelina, K. Siviero, F. Sola, V. Solano, A. Soldi, D. Staiano, A. Tornago, M. Trocino, D. Belforte, S. Candelise, V. Casarsa, M. Cossutti, F. Da Rold, A. Della Ricca, G. Sorrentino, G. Vazzoler, F. Dogra, S. Huh, C. Kim, B. Kim, D.H. Kim, G.N. Lee, J. Lee, S.W. Moon, C.S. Oh, Y.D. Pak, S.I. Radburn-Smith, B.C. Sekmen, S. Yang, Y.C. Kim, H. Moon, D.H. Kim, T.J. Park, J. Cho, S. Choi, S. Go, Y. Hong, B. Lee, K.S. Lim, J. Park, S.K. Yoo, J. Goh, J. Gurtu, A. Kim, H.S. Kim, Y. Almond, J. Bhyun, J.H. Choi, J. Jeon, S. Kim, J. Kim, J.S. Ko, S. Kwon, H. Lee, H. Lee, S. Oh, B.H. Oh, M. Oh, S.B. Seo, H. Yang, U.K. Yoon, I. Jeon, D. Kim, J.H. Ko, B. Lee, J.S.H. Park, I.C. Roh, Y. Song, D. Watson, I.J. Ha, S. Yoo, H.D. Choi, Y. Jeong, Y. Lee, Y. Yu, I. Beyrouthy, T. Maghrbi, Y. Veckalns, V. Ambrozas, M. Juodagalvis, A. Rinkevicius, A. Tamulaitis, G. Vaitkevicius, A. Bin Norjoharuddeen, N. Wan Abdullah, W.A.T. Yusli, M.N. Zolkapli, Z. Benitez, J.F. Castaneda Hernandez, A. Murillo Quijada, J.A. Valencia Palomo, L. Ayala, G. Castilla-Valdez, H. De La Cruz-Burelo, E. Heredia-De La Cruz, I. Lopez-Fernandez, R. Mondragon Herrera, C.A. Perez Navarro, D.A. Sanchez-Hernandez, A. Carrillo Moreno, S. Oropeza Barrera, C. Ramirez-Garcia, M. Vazquez Valencia, F. Pedraza, I. Salazar Ibarguen, H.A. Uribe Estrada, C. Mijuskovic, J. Raicevic, N. Krofcheck, D. Bheesette, S. Butler, P.H. Ahmad, A. Asghar, M.I. Awais, A. Awan, M.I.M. Hoorani, H.R. Khan, W.A. Shah, M.A. Shoaib, M. Waqas, M. Avati, V. Grzanka, L. Malawski, M. Bialkowska, H. Bluj, M. Boimska, B. Frueboes, T. Górski, M. Kazana, M. Szleper, M. Traczyk, P. Zalewski, P. Bunkowski, K. Doroba, K. Kalinowski, A. Konecki, M. Krolikowski, J. Walczak, M. Araujo, M. Bargassa, P. Bastos, D. Boletti, A. Faccioli, P. Gallinaro, M. Hollar, J. Leonardo, N. Niknejad, T. Seixas, J. Toldaiev, O. Varela, J. Afanasiev, S. Budkouski, D. Bunin, P. Gavrilenko, M. Golutvin, I. Gorbunov, I. Kamenev, A. Karjavine, V. Lanev, A. Malakhov, A. Matveev, V. Palichik, V. Perelygin, V. Savina, M. Seitova, D. Shalaev, V. Shmatov, S. Shulha, S. Smirnov, V. Teryaev, O. Voytishin, N. Zarubin, A. Zhizhin, I. Gavrilov, G. Golovtcov, V. Ivanov, Y. Kim, V. Kuznetsova, E. Murzin, V. Oreshkin, V. Smirnov, I. Sosnov, D. Sulimov, V. Uvarov, L. Volkov, S. Vorobyev, A. Andreev, Y. Dermenev, A. Gninenko, S. Golubev, N. Karneyeu, A. Kirsanov, M. Krasnikov, N. Pashenkov, A. Pivovarov, G. Tlisov, D. Toropin, A. Epshteyn, V. Gavrilov, V. Lychkovskaya, N. Nikitenko, A. Popov, V. Safronov, G. Spiridonov, A. Stepennov, A. Toms, M. Vlasov, E. Zhokin, A. Aushev, T. Bychkova, O. Chadeeva, M. Parygin, P. Popova, E. Rusinov, V. Andreev, V. Azarkin, M. Dremin, I. Kirakosyan, M. Terkulov, A. Belyaev, A. Boos, E. Dubinin, M. Dudko, L. Ershov, A. Gribushin, A. Klyukhin, V. Kodolova, O. Lokhtin, I. Obraztsov, S. Petrushanko, S. Savrin, V. Snigirev, A. Blinov, V. Dimova, T. Kardapoltsev, L. Ovtin, I. Skovpen, Y. Azhgirey, I. Bayshev, I. Kachanov, V. Kalinin, A. Konstantinov, D. Petrov, V. Ryutin, R. Sobol, A. Troshin, S. Tyurin, N. Uzunian, A. Volkov, A. Babaev, A. Okhotnikov, V. Sukhikh, L. Borchsh, V. Ivanchenko, V. Tcherniaev, E. Adzic, P. Dordevic, M. Milenovic, P. Milosevic, J. Milosevic, V. Aguilar-Benitez, M. Alcaraz Maestre, J. Álvarez Fernández, A. Bachiller, I. Barrio Luna, M. Bedoya, C.F. Carrillo Montoya, C.A. Cepeda, M. Cerrada, M. Colino, N. De La Cruz, B. Delgado Peris, A. Fernández Ramos, J.P. Flix, J. Fouz, M.C. Gonzalez Lopez, O. Goy Lopez, S. Hernandez, J.M. Josa, M.I. León Holgado, J. Moran, D. Navarro Tobar, Á. Pérez-Calero Yzquierdo, A. Puerta Pelayo, J. Redondo, I. Romero, L. Sánchez Navas, S. Soares, M.S. Urda Gómez, L. Willmott, C. de Trocóniz, J.F. Reyes-Almanza, R. Alvarez Gonzalez, B. Cuevas, J. Erice, C. Fernandez Menendez, J. Folgueras, S. Gonzalez Caballero, I. Palencia Cortezon, E. Ramón Álvarez, C. Ripoll Sau, J. Rodríguez Bouza, V. Trapote, A. Brochero Cifuentes, J.A. Cabrillo, I.J. Calderon, A. Chazin Quero, B. Duarte Campderros, J. Fernandez, M. Fernandez Madrazo, C. Fernández Manteca, P.J. García Alonso, A. Gomez, G. Martinez Rivero, C. Martinez Ruiz del Arbol, P. Matorras, F. Piedra Gomez, J. Prieels, C. Ricci-Tam, F. Rodrigo, T. Ruiz-Jimeno, A. Scodellaro, L. Trevisani, N. Vila, I. Vizan Garcia, J.M. Jayananda, M.K. Kailasapathy, B. Sonnadara, D.U.J. Wickramarathna, D.D.C. Dharmaratna, W.G.D. Liyanage, K. Perera, N. Wickramage, N. Aarrestad, T.K. Abbaneo, D. Alimena, J. Auffray, E. Auzinger, G. Baechler, J. Baillon, P. Ball, A.H. Barney, D. Bendavid, J. Beni, N. Bianco, M. Bocci, A. Brondolin, E. Camporesi, T. Capeans Garrido, M. Cerminara, G. Chhibra, S.S. Cristella, L. d'Enterria, D. Dabrowski, A. Daci, N. David, A. De Roeck, A. Deile, M. Di Maria, R. Dobson, M. Dünser, M. Dupont, N. Elliott-Peisert, A. Emriskova, N. Fallavollita, F. Fasanella, D. Fiorendi, S. Florent, A. Franzoni, G. Fulcher, J. Funk, W. Giani, S. Gigi, D. Gill, K. Glege, F. Gouskos, L. Haranko, M. Hegeman, J. Iiyama, Y. Innocente, V. James, T. Janot, P. Kaspar, J. Kieseler, J. Komm, M. Kratochwil, N. Lange, C. Laurila, S. Lecoq, P. Long, K. Lourenço, C. Malgeri, L. Mallios, S. Mannelli, M. Meijers, F. Mersi, S. Meschi, E. Moortgat, F. Mulders, M. Orfanelli, S. Orsini, L. Pantaleo, F. Pape, L. Perez, E. Peruzzi, M. Petrilli, A. Petrucciani, G. Pfeiffer, A. Pierini, M. Pitt, M. Qu, H. Quast, T. Rabady, D. Racz, A. Rieger, M. Rovere, M. Sakulin, H. Salfeld-Nebgen, J. Scarfi, S. Schäfer, C. Schwick, C. Selvaggi, M. Silva, P. Snoeys, W. Sphicas, P. Summers, S. Tavolaro, V.R. Treille, D. Tsirou, A. Van Onsem, G.P. Verzetti, M. Wanczyk, J. Wozniak, K.A. Zeuner, W.D. Caminada, L. Ebrahimi, A. Erdmann, W. Horisberger, R. Ingram, Q. Kaestli, H.C. Kotlinski, D. Langenegger, U. Missiroli, M. Rohe, T. Androsov, K. Backhaus, M. Berger, P. Calandri, A. Chernyavskaya, N. De Cosa, A. Dissertori, G. Dittmar, M. Donegà, M. Dorfer, C. Eble, F. Gadek, T. Gómez Espinosa, T.A. Grab, C. Hits, D. Lustermann, W. Lyon, A.-M. Manzoni, R.A. Martin Perez, C. Meinhard, M.T. Micheli, F. Nessi-Tedaldi, F. Niedziela, J. Pauss, F. Perovic, V. Perrin, G. Pigazzini, S. Ratti, M.G. Reichmann, M. Reissel, C. Reitenspiess, T. Ristic, B. Ruini, D. Sanz Becerra, D.A. Schönenberger, M. Stampf, V. Steggemann, J. Wallny, R. Zhu, D.H. Amsler, C. Bärtschi, P. Botta, C. Brzhechko, D. Canelli, M.F. De Wit, A. Del Burgo, R. Heikkilä, J.K. Huwiler, M. Jofrehei, A. Kilminster, B. Leontsinis, S. Macchiolo, A. Meiring, P. Mikuni, V.M. Molinatti, U. Neutelings, I. Rauco, G. Reimers, A. Robmann, P. Sanchez Cruz, S. Schweiger, K. Takahashi, Y. Adloff, C. Kuo, C.M. Lin, W. Roy, A. Sarkar, T. Yu, S.S. Ceard, L. Chang, P. Chao, Y. Chen, K.F. Chen, P.H. Hou, W.-S. Li, Y.Y. Lu, R.-S. Paganis, E. Psallidas, A. Steen, A. Yazgan, E. Yu, P.R. Asavapibhop, B. Asawatangtrakuldee, C. Srimanobhas, N. Boran, F. Damarseckin, S. Demiroglu, Z.S. Dolek, F. Dumanoglu, I. Eskut, E. Gokbulut, G. Guler, Y. Gurpinar Guler, E. Hos, I. Isik, C. Kangal, E.E. Kara, O. Kayis Topaksu, A. Kiminsu, U. Onengut, G. Ozdemir, K. Polatoz, A. Simsek, A.E. Tali, B. Tok, U.G. Turkcapar, S. Zorbakir, I.S. Zorbilmez, C. Isildak, B. Karapinar, G. Ocalan, K. Yalvac, M. Akgun, B. Atakisi, I.O. Gülmez, E. Kaya, M. Kaya, O. Özçelik, Ö. Tekten, S. Yetkin, E.A. Cakir, A. Cankocak, K. Komurcu, Y. Sen, S. Aydogmus Sen, F. Cerci, S. Kaynak, B. Ozkorucuklu, S. Sunar Cerci, D. Grynyov, B. Levchuk, L. Bhal, E. Bologna, S. Brooke, J.J. Bundock, A. Clement, E. Cussans, D. Flacher, H. Goldstein, J. Heath, G.P. Heath, H.F. Kreczko, L. Krikler, B. Paramesvaran, S. Sakuma, T. Seif El Nasr-Storey, S. Smith, V.J. Stylianou, N. Taylor, J. Titterton, A. Bell, K.W. Brew, C. Brown, R.M. Cockerill, D.J.A. Ellis, K.V. Harder, K. Harper, S. Linacre, J. Manolopoulos, K. Newbold, D.M. Olaiya, E. Petyt, D. Reis, T. Schuh, T. Shepherd-Themistocleous, C.H. Thea, A. Tomalin, I.R. Williams, T. Bainbridge, R. Bloch, P. Bonomally, S. Borg, J. Breeze, S. Buchmuller, O. Cepaitis, V. Chahal, G.S. Colling, D. Dauncey, P. Davies, G. Della Negra, M. Fayer, S. Fedi, G. Hall, G. Hassanshahi, M.H. Iles, G. Langford, J. Lyons, L. Magnan, A.-M. Malik, S. Martelli, A. Nash, J. Palladino, V. Pesaresi, M. Raymond, D.M. Richards, A. Rose, A. Scott, E. Seez, C. Shtipliyski, A. Tapper, A. Uchida, K. Virdee, T. Wardle, N. Webb, S.N. Winterbottom, D. Zecchinelli, A.G. Cole, J.E. Khan, A. Kyberd, P. Mackay, C.K. Reid, I.D. Teodorescu, L. Zahid, S. Abdullin, S. Brinkerhoff, A. Caraway, B. Dittmann, J. Hatakeyama, K. Kanuganti, A.R. McMaster, B. Pastika, N. Sawant, S. Smith, C. Sutantawibul, C. Wilson, J. Bartek, R. Dominguez, A. Uniyal, R. Vargas Hernandez, A.M. Buccilli, A. Charaf, O. Cooper, S.I. Di Croce, D. Gleyzer, S.V. Henderson, C. Perez, C.U. Rumerio, P. West, C. Akpinar, A. Albert, A. Arcaro, D. Cosby, C. Demiragli, Z. Gastler, D. Rohlf, J. Salyer, K. Sperka, D. Spitzbart, D. Suarez, I. Tsatsos, A. Yuan, S. Zou, D. Benelli, G. Burkle, B. Coubez, X. Cutts, D. Duh, Y.T. Hadley, M. Heintz, U. Hogan, J.M. Laird, E. Landsberg, G. Lau, K.T. Luo, J. Narain, M. Sagir, S. Usai, E. Wong, W.Y. Yan, X. Yu, D. Zhang, W. Brainerd, C. Breedon, R. Calderon De La Barca Sanchez, M. Chertok, M. Conway, J. Cox, P.T. Erbacher, R. Jensen, F. Kukral, O. Lander, R. Mulhearn, M. Pellett, D. Regnery, B. Taylor, D. Tripathi, M. Yao, Y. Zhang, F. Bachtis, M. Cousins, R. Dasgupta, A. Datta, A. Hamilton, D. Hauser, J. Ignatenko, M. Iqbal, M.A. Lam, T. Mccoll, N. Nash, W.A. Regnard, S. Saltzberg, D. Schnaible, C. Stone, B. Valuev, V. Burt, K. Chen, Y. Clare, R. Gary, J.W. Hanson, G. Karapostoli, G. Long, O.R. Manganelli, N. Olmedo Negrete, M. Si, W. Wimpenny, S. Zhang, Y. Branson, J.G. Cittolin, S. Cooperstein, S. Deelen, N. Duarte, J. Gerosa, R. Giannini, L. Gilbert, D. Guiang, J. Kansal, R. Krutelyov, V. Lee, R. Letts, J. Masciovecchio, M. May, S. Padhi, S. Pieri, M. Sathia Narayanan, B.V. Sharma, V. Tadel, M. Vartak, A. Würthwein, F. Xiang, Y. Yagil, A. Amin, N. Campagnari, C. Citron, M. Dorsett, A. Dutta, V. Incandela, J. Kilpatrick, M. Marsh, B. Mei, H. Oshiro, M. Ovcharova, A. Quinnan, M. Richman, J. Sarica, U. Stuart, D. Wang, S. Bornheim, A. Cerri, O. Dutta, I. Lawhorn, J.M. Lu, N. Mao, J. Newman, H.B. Ngadiuba, J. Nguyen, T.Q. Spiropulu, M. Vlimant, J.R. Wang, C. Xie, S. Zhang, Z. Zhu, R.Y. Alison, J. Andrews, M.B. Ferguson, T. Mudholkar, T. Paulini, M. Vorobiev, I. Cumalat, J.P. Ford, W.T. MacDonald, E. Patel, R. Perloff, A. Stenson, K. Ulmer, K.A. Wagner, S.R. Alexander, J. Cheng, Y. Chu, J. Cranshaw, D.J. Mcdermott, K. Monroy, J. Patterson, J.R. Quach, D. Reichert, J. Ryd, A. Sun, W. Tan, S.M. Tao, Z. Thom, J. Wittich, P. Zientek, M. Albrow, M. Alyari, M. Apollinari, G. Apresyan, A. Apyan, A. Bauerdick, L.A.T. Beretvas, A. Berry, D. Berryhill, J. Bhat, P.C. Burkett, K. Butler, J.N. Canepa, A. Cerati, G.B. Cheung, H.W.K. Chlebana, F. Cremonesi, M. Di Petrillo, K.F. Elvira, V.D. Freeman, J. Gecse, Z. Gray, L. Green, D. Grünendahl, S. Gutsche, O. Harris, R.M. Heller, R. Herwig, T.C. Hirschauer, J. Jayatilaka, B. Jindariani, S. Johnson, M. Joshi, U. Klabbers, P. Klijnsma, T. Klima, B. Kortelainen, M.J. Kwok, K.H.M. Lammel, S. Lincoln, D. Lipton, R. Liu, T. Lykken, J. Madrid, C. Maeshima, K. Mantilla, C. Mason, D. McBride, P. Merkel, P. Mrenna, S. Nahn, S. O'Dell, V. Papadimitriou, V. Pedro, K. Pena, C. Prokofyev, O. Ravera, F. Reinsvold Hall, A. Ristori, L. Schneider, B. Sexton-Kennedy, E. Smith, N. Soha, A. Spiegel, L. Stoynev, S. Strait, J. Taylor, L. Tkaczyk, S. Tran, N.V. Uplegger, L. Vaandering, E.W. Weber, H.A. Woodard, A. Acosta, D. Avery, P. Bourilkov, D. Cadamuro, L. Cherepanov, V. Errico, F. Field, R.D. Guerrero, D. Joshi, B.M. Kim, M. Konigsberg, J. Korytov, A. Lo, K.H. Matchev, K. Menendez, N. Mitselmakher, G. Rosenzweig, D. Shi, K. Sturdy, J. Yigitbasi, E. Zuo, X. Adams, T. Askew, A. Diaz, D. Habibullah, R. Hagopian, S. Hagopian, V. Johnson, K.F. Khurana, R. Kolberg, T. Martinez, G. Prosper, H. Schiber, C. Yohay, R. Zhang, J. Baarmand, M.M. Butalla, S. Elkafrawy, T. Hohlmann, M. Kumar Verma, R. Noonan, D. Rahmani, M. Saunders, M. Yumiceva, F. Adams, M.R. Apanasevich, L. Becerril Gonzalez, H. Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, O. Gerber, C.E. Hangal, D.A. Hofman, D.J. Mills, C. Oh, G. Roy, T. Tonjes, M.B. Varelas, N. Viinikainen, J. Wang, X. Wu, Z. Ye, Z. Alhusseini, M. Dilsiz, K. Durgut, S. Gandrajula, R.P. Haytmyradov, M. Khristenko, V. Köseyan, O.K. Merlo, J.-P. Mestvirishvili, A. Moeller, A. Nachtman, J. Ogul, H. Onel, Y. Ozok, F. Penzo, A. Snyder, C. Tiras, E. Wetzel, J. Amram, O. Blumenfeld, B. Corcodilos, L. Davis, J. Eminizer, M. Gritsan, A.V. Kyriacou, S. Maksimovic, P. Roskes, J. Swartz, M. Vámi, T.Á. Baldenegro Barrera, C. Baringer, P. Bean, A. Bylinkin, A. Isidori, T. Khalil, S. King, J. Krintiras, G. Kropivnitskaya, A. Lindsey, C. Minafra, N. Murray, M. Rogan, C. Royon, C. Sanders, S. Schmitz, E. Tapia Takaki, J.D. Williams, J. Wilson, G. Duric, S. Ivanov, A. Kaadze, K. Kim, D. Maravin, Y. Mitchell, T. Modak, A. Nam, K. Rebassoo, F. Wright, D. Adams, E. Baden, A. Baron, O. Belloni, A. Eno, S.C. Feng, Y. Hadley, N.J. Jabeen, S. Kellogg, R.G. Koeth, T. Mignerey, A.C. Nabili, S. Seidel, M. Skuja, A. Tonwar, S.C. Wang, L. Wong, K. Abercrombie, D. Andreassi, G. Bi, R. Brandt, S. Busza, W. Cali, I.A. D'Alfonso, M. Gomez Ceballos, G. Goncharov, M. Harris, P. Hu, M. Klute, M. Kovalskyi, D. Krupa, J. Lee, Y.-J. Maier, B. Marini, A.C. Mironov, C. Paus, C. Rankin, D. Roland, C. Roland, G. Shi, Z. Stephans, G.S.F. Tatar, K. Wang, Z. Wyslouch, B. Chatterjee, R.M. Evans, A. Hansen, P. Hiltbrand, J. Jain, S. Krohn, M. Kubota, Y. Lesko, Z. Mans, J. Revering, M. Rusack, R. Saradhy, R. Schroeder, N. Strobbe, N. Wadud, M.A. Acosta, J.G. Oliveros, S. Bloom, K. Bryson, M. Claes, D.R. Fangmeier, C. Finco, L. Golf, F. González Fernández, J.R. Joo, C. Kravchenko, I. Musich, M. Siado, J.E. Snow, G.R. Tabb, W. Yan, F. Agarwal, G. Bandyopadhyay, H. Hay, L. Iashvili, I. Kharchilava, A. McLean, C. Nguyen, D. Pekkanen, J. Rappoccio, S. Williams, A. Alverson, G. Barberis, E. Freer, C. Haddad, Y. Hortiangtham, A. Li, J. Madigan, G. Marzocchi, B. Morse, D.M. Nguyen, V. Orimoto, T. Parker, A. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. Wang, B. Wisecarver, A. Wood, D. Bueghly, J. Chen, Z. Gilbert, A. Gunter, T. Hahn, K.A. Odell, N. Schmitt, M.H. Sung, K. Velasco, M. Band, R. Bucci, R. Dev, N. Goldouzian, R. Hildreth, M. Hurtado Anampa, K. Jessop, C. Lannon, K. Loukas, N. Marinelli, N. Mcalister, I. Meng, F. Mohrman, K. Musienko, Y. Ruchti, R. Siddireddy, P. Wayne, M. Wightman, A. Wolf, M. Zarucki, M. Zygala, L. Bylsma, B. Cardwell, B. Durkin, L.S. Francis, B. Hill, C. Lefeld, A. Winer, B.L. Yates, B.R. Addesa, F.M. Bonham, B. Das, P. Dezoort, G. Elmer, P. Frankenthal, A. Greenberg, B. Haubrich, N. Higginbotham, S. Kalogeropoulos, A. Kopp, G. Kwan, S. Lange, D. Lucchini, M.T. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. Palmer, C. Stickland, D. Tully, C. Norberg, S. Bakshi, A.S. Barnes, V.E. Chawla, R. Das, S. Gutay, L. Jones, M. Jung, A.W. Karmarkar, S. Liu, M. Negro, G. Neumeister, N. Paspalaki, G. Peng, C.C. Piperov, S. Purohit, A. Schulte, J.F. Stojanovic, M. Thieman, J. Wang, F. Xiao, R. Xie, W. Dolen, J. Parashar, N. Baty, A. Dildick, S. Ecklund, K.M. Freed, S. Geurts, F.J.M. Li, W. Padley, B.P. Redjimi, R. Roberts, J. Shi, W. Stahl Leiton, A.G. Bodek, A. de Barbaro, P. Demina, R. Dulemba, J.L. Fallon, C. Ferbel, T. Galanti, M. Garcia-Bellido, A. Hindrichs, O. Khukhunaishvili, A. Ranken, E. Taus, R. Chiarito, B. Chou, J.P. Gandrakota, A. Gershtein, Y. Halkiadakis, E. Hart, A. Heindl, M. Hughes, E. Kaplan, S. Karacheban, O. Laflotte, I. Lath, A. Montalvo, R. Nash, K. Osherson, M. Salur, S. Schnetzer, S. Somalwar, S. Stone, R. Thayil, S.A. Thomas, S. Acharya, H. Delannoy, A.G. Spanier, S. Bouhali, O. Dalchenko, M. Delgado, A. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Luo, S. Malhotra, S. Mueller, R. Overton, D. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. Hegde, V. Kunori, S. Lamichhane, K. Mengke, T. Muthumuni, S. Peltola, T. Undleeb, S. Volobouev, I. Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Maguire, C. Melo, A. Ni, H. Padeken, K. Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Arenton, M.W. Cox, B. Cummings, G. Hakala, J. Hirosky, R. Joyce, M. Ledovskoy, A. Li, A. Neu, C. Tannenwald, B. Wolfe, E. Karchin, P.E. Poudyal, N. Thapa, P. Black, K. Bose, T. Buchanan, J. Caillol, C. Dasu, S. De Bruyn, I. Everaerts, P. Fienga, F. Galloni, C. He, H. Herndon, M. Hervé, A. Hussain, U. Lanaro, A. Loeliger, A. Loveless, R. Madhusudanan Sreekala, J. Mallampalli, A. Mohammadi, A. Pinna, D. Savin, A. Shang, V. Smith, W.H. Teague, D. Trembath-reichert, S. Vetens, W. The CMS Collaboration

Subjects
High Energy Physics::Experiment
Abstract

A search for Wγ resonances in the mass range between 0.7 and 6.0 TeV is presented. The W boson is reconstructed via its hadronic decays, with the final-state products forming a single large-radius jet, owing to a high Lorentz boost of the W boson. The search is based on proton-proton collision data at s=13 TeV, corresponding to an integrated luminosity of 137 fb−1, collected with the CMS detector at the LHC in 2016–2018. The Wγ mass spectrum is parameterized with a smoothly falling background function and examined for the presence of resonance-like signals. No significant excess above the predicted background is observed. Model-specific upper limits at 95% confidence level on the product of the cross section and branching fraction to the Wγ channel are set. Limits for narrow resonances and for resonances with an intrinsic width equal to 5% of their mass, for spin-0 and spin-1 hypotheses, range between 0.17 fb at 6.0 TeV and 55 fb at 0.7 TeV. These are the most restrictive limits to date on the existence of such resonances over a large range of probed masses. In specific heavy scalar (vector) triplet benchmark models, narrow resonances with masses between 0.75 (1.15) and 1.40 (1.36) TeV are excluded for a range of model parameters. Model-independent limits on the product of the cross section, signal acceptance, and branching fraction to the Wγ channel are set for minimum Wγ mass thresholds between 1.5 and 8.0 TeV. © 2022 The Author(s)

Published
2022

228. Experimental rhinovirus infection induces an antiviral response in circulating B cells which is dysregulated in patients with asthma

Author

Wirz, O.F. Jansen, K. Satitsuksanoa, P. van de Veen, W. Tan, G. Sokolowska, M. Mirer, D. Stanić, B. Message, S.D. Kebadze, T. Glanville, N. Mallia, P. Gern, J.E. Papadopoulos, N. Akdis, C.A. Johnston, S.L. Nadeau, K. Akdis, M.

Subjects
stomatognathic system, viruses, respiratory tract diseases
Abstract

Background: Rhinoviruses are the predominant cause of respiratory viral infections and are strongly associated with asthma exacerbations. While humoral immunity plays an important role during virus infections, cellular aspects of this response are less well understood. Here, we investigated the antiviral response of circulating B cells upon experimental rhinovirus infection in healthy individuals and asthma patients. Methods: We purified B cells from experimentally infected healthy individuals and patients with asthma and subjected them to total RNA-sequencing. Rhinovirus-derived RNA was measured in isolated B cells using a highly sensitive PCR. B cells were stimulated with rhinovirus in vitro to further study gene expression, expression of antiviral proteins and B-cell differentiation in response rhinovirus stimulation. Protein expression of pro-inflammatory cytokines in response to rhinovirus was assessed using a proximity extension assay. Results: B cells isolated from experimentally infected subjects exhibited an antiviral gene profile linked to IFN-alpha, carried viral RNA in vivo and were transiently infected by rhinovirus in vitro. B cells rapidly differentiated into plasmablasts upon rhinovirus stimulation. While B cells lacked expression of interferons in response to rhinovirus exposure, co-stimulation with rhinovirus and IFN-alpha upregulated pro-inflammatory cytokine expression suggesting a potential new function of B cells during virus infections. Asthma patients showed extensive upregulation and dysregulation of antiviral gene expression. Conclusion: These findings add to the understanding of systemic effects of rhinovirus infections on B-cell responses in the periphery, show potential dysregulation in patients with asthma and might also have implications during infection with other respiratory viruses. © 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Published
2022

229. Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

Author

Johann S, Hawe, Rory, Wilson, Katharina T, Schmid, Li, Zhou, Lakshmi Narayanan, Lakshmanan, Benjamin C, Lehne, Brigitte, Kühnel, William R, Scott, Matthias, Wielscher, Yik Weng, Yew, Clemens, Baumbach, Dominic P, Lee, Eirini, Marouli, Manon, Bernard, Liliane, Pfeiffer, Pamela R, Matías-García, Matias I, Autio, Stephane, Bourgeois, Christian, Herder, Ville, Karhunen, Thomas, Meitinger, Holger, Prokisch, Wolfgang, Rathmann, Michael, Roden, Sylvain, Sebert, Jean, Shin, Konstantin, Strauch, Weihua, Zhang, Wilson L W, Tan, Stefanie M, Hauck, Juliane, Merl-Pham, Harald, Grallert, Eudes G V, Barbosa, Thomas, Illig, Annette, Peters, Tomas, Paus, Zdenka, Pausova, Panos, Deloukas, Roger S Y, Foo, Marjo-Riitta, Jarvelin, Jaspal S, Kooner, Marie, Loh, Matthias, Heinig, Christian, Gieger, Melanie, Waldenberger, and Krina T, Zondervan

Subjects
DNA Replication, Asia, Quantitative Trait Loci, Genetic Variation, Blood Pressure, CD8-Positive T-Lymphocytes, DNA Methylation, Polymorphism, Single Nucleotide, Body Mass Index, Arthritis, Rheumatoid, Europe, Leukocytes, Genetics, Humans, CpG Islands, Genome-Wide Association Study
Abstract

We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P

Published
2022

230. Knowledge and Interdisciplinary Communication of Gastroenterologists and Dentists in the Netherlands about Gastrointestinal Diseases with Oral Manifestations

Author

Christopher X W Tan, Henk S Brand, Oumaima Qaddour, Paulette M L van der Bijl, Nanne K H De Boer, Tymour Forouzanfar, Jan G A M de Visscher, Oral and Maxillofacial Surgery / Oral Pathology, Gastroenterology and hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, AMS - Tissue Function & Regeneration, Maxillofacial Surgery (VUmc), Oral Biochemistry, and Maxillofacial Surgery (AMC + VUmc)

Subjects
Crohn's disease, Gastroenterology, oral manifestations of inflammatory bowel diseases, inflammatory bowel diseases, interdisciplinary communication/consultation, ulcerative colitis
Abstract

Background Gastrointestinal diseases can have oral manifestations. The aim of this study was to investigate the knowledge of gastroenterologists and dentists about gastrointestinal diseases with oral manifestations and to assess the frequency, extent and content of communication between gastroenterologists and oral healthcare professionals. Methods Separate questionnaires were developed and sent to all 523 gastroenterologists and a random selection of 500 dentists in the Netherlands. Both questionnaires contained questions about demographic characteristics of the participants, 10 statements about gastrointestinal diseases with possible oral manifestations and questions about the communication between gastroenterologists and oral healthcare professionals. Additionally, the questionnaire for gastroenterologists contained 9 statements about general dentistry and the questionnaire for dentist had 9 questions about gastrointestinal diseases. Results Gastroenterologists answered 47.6% ± 31.9% of the questions correct about gastrointestinal diseases with possible oral manifestations and 57.5% ± 27.9% of the questions correct about general dentistry. Dentists answered 26.6% ± 20.5% of the questions correct about possible oral manifestations of gastrointestinal diseases and 50.3% ± 18.7% of the questions correct about gastrointestinal diseases. Gastroenterologists and dentists valued interdisciplinary consultation as very useful with scores of 4.07 ± 0.70 and 4.67 ± 0.49 on a 5-point Likert scale, respectively, but the frequency of consultation was considered insufficiently with a mean score of 2.88 ± 1.01 and 2.24 ± 1.05 on a 5-point Likert scale, respectively. Conclusions This study suggests that the knowledge of gastroenterologists and dentists about gastrointestinal diseases with oral manifestations could be improved. Interdisciplinary consultation was considered valuable for the optimal treatment of their patients but was assessed as insufficient.

Published
2022
Full Text
View/download PDF

232. Lead Poisoning From Home-Prepared Indian Spices in 3 Families

Author

Shirlee W. Tan, Sharon G. Cohen, Matt A. Wilson, Tory P. Johnson, and Jessica A. Ivers

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Spice consumption, along with other environmental factors, can contribute to pediatric lead poisoning. Although public health efforts have increased awareness of contamination of spices, false assumptions regarding the safety of home-prepared spices have emerged. Here, we present the clinical features, family beliefs, and environmental toxicology of 3 spice-associated pediatric lead poisoning cases.

Published
2023
Full Text
View/download PDF

233. The effect of water deficit and excess copper on proline metabolism in Nicotiana benthamiana

Author

H. -M. Ku, C. -W. Tan, Y. -S. Su, C. -Y. Chiu, C. -T. Chen, and F. -J. Jan

Subjects
abscisic acid, gene expression, tobacco, Biology (General), QH301-705.5, Plant ecology, QK900-989
Abstract

Fluctuation in proline content is a widespread phenomenon among plants in response to heavy metal stress. To distinguish between the participation of water deficit and copper on changes in proline metabolism, potted plants and floating leaf discs of tobacco were subjected to CuSO4 treatments. The application of copper increased the proline content in the leaves concomitantly with decreased leaf relative water content and increased abscisic acid (ABA) content in the potted plant. Excess copper increased the expression of two proline synthesis genes, pyrroline-5-carboxylate synthetase (P5CS) and ornithine aminotransferase (OAT) and suppressed proline catabolism gene, proline dehydrogenase (PDH). However, in the experiment with tobacco leaf discs floating on CuSO4 solutions, the excess copper decreased proline content and suppressed the expression of the P5CS, OAT and PDH genes. Therefore, proline accumulation in the potted tobacco plants treated with excess Cu treatment might not be the consequence of the increased copper content in tobacco leaves but rather by the accompanied decrease in water content and/or increased ABA content.

Published
2012
Full Text
View/download PDF

238. 126P AdvanTIG-105: Phase Ib dose-expansion study of ociperlimab (OCI) + tislelizumab (TIS) in patients (pts) with checkpoint inhibitor (CPI)-experienced advanced non-small cell lung cancer (NSCLC)

Author

S. Frentzas, T. Meniawy, S.C-H. Kao, J. Coward, T.D. Clay, N. Singhal, A. Black, W. Xu, R. Kumar, Y. Lee, G-W. Lee, W. Liao, D. Zhong, H-S. Shiah, Y-M. Chen, R. Gao, R. Wang, H. Zheng, W. Tan, and E.K. Cho

Subjects
Oncology, Immunology and Allergy
Published
2022
Full Text
View/download PDF

243. Gain Improvement of $\hbox{Er-Ti:LiNbO}_{3}$ Waveguide Amplifier by an $\hbox{As}_{2}\hbox{S}_{3}$ Overlay Waveguide

Author

X. Song, W. Tan, W. T. Snider, X. Xia, and C. K. Madsen

Subjects
Arsenic trisulfide, erbium (Er)-doped waveguide amplifiers, titanium-diffused lithium niobate, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

A new configuration consisting of an arsenic trisulfide (As2S3) channel waveguide on top of an erbium (Er)-doped titanium-diffused x-cut lithium niobate (Er:Ti:LiNbO3) waveguide has been investigated by simultaneous analytical expressions, numerical simulations, and experimentation. Both simulation and experimental results have shown that this structure can enhance the optical gain, as predicted by the analytical expressions. An As2S3 channel waveguide has been fabricated on top of a conventional Er:Ti:LiNbO3 waveguide, where the higher refractive index As2S3 waveguide is used to pull the optical mode toward the substrate surface where the higher Er concentration yields an improved propagation gain. The relationship between the gain and As2S3 layer thickness has been evaluated, and the optimal As2S3 thickness was found by simulation and experimentation. Side integration was applied to reduce the extrapropagation loss caused by the titanium diffusion bump. The propagation gain has been improved from 1.1 to 2 dB/cm.

Published
2011
Full Text
View/download PDF

244. Development of Novel Intramolecular FRET-Based ABC Transporter Biosensors to Identify New Substrates and Modulators

Author

Bremansu Osa-Andrews, Kee W. Tan, Angelina Sampson, and Surtaj H. Iram

Subjects
ATP-binding cassette (ABC) proteins, multidrug resistance, fluorescence resonance energy transfer, biosensors, multidrug resistance protein 1, two-color MRP1, Pharmacy and materia medica, RS1-441
Abstract

Multidrug resistance protein 1 (MRP1) can efflux a wide variety of molecules including toxic chemicals, drugs, and their derivatives out of cells. Substrates of MRP1 include anti-cancer agents, antibiotics, anti-virals, anti-human immunodeficiency virus (HIV), and many other drugs. To identify novel substrates and modulators of MRP1 by exploiting intramolecular fluorescence resonance energy transfer (FRET), we genetically engineered six different two-color MRP1 proteins by changing green fluorescent protein (GFP) insertion sites, while keeping the red fluorescent protein (RFP) at the C-terminal of MRP1. Four of six recombinant proteins showed normal expression, localization, and transport activity. We quantified intramolecular FRET using ensemble fluorescence spectroscopy in response to binding of known substrate or ATP alone, substrate/ATP, and trapping of the transporter in closed conformation by vanadate. Recombinant MRP1 proteins GR-881, GR-888, and GR-905 exhibited reproducible and higher FRET changes under all tested conditions and are very promising for use as MRP1 biosensors. Furthermore, we used GR-881 to screen 40 novel anti-cancer drugs and identified 10 hits that potentially directly interact with MRP1 and could be substrates or modulators. Profiling of drug libraries for interaction with MRP1 can provide very useful information to improve the efficacy and reduce the toxicity of various therapies.

Published
2018
Full Text
View/download PDF

245. Repair of Anomalous Left Anterior Descending Coronary Artery Arising From the Pulmonary Artery Using a Dacron Interposition Bypass Graft

Author

Corinne W. Tan, Margaret Holland, and Luis G. Quinonez

Subjects
medicine.medical_specialty, business.industry, Adult case, General Medicine, 030204 cardiovascular system & hematology, Anterior Descending Coronary Artery, Surgery, 03 medical and health sciences, surgical procedures, operative, 0302 clinical medicine, medicine.anatomical_structure, 030228 respiratory system, medicine.artery, Pediatrics, Perinatology and Child Health, Pulmonary artery, Medicine, Cardiology and Cardiovascular Medicine, business, Interposition graft, Artery
Abstract

An anomalous left anterior descending artery arising from the pulmonary artery (ALADAPA) is exceedingly rare. We present an adult case of ALADAPA that was repaired using a Dacron interposition graft.

Published
2021
Full Text
View/download PDF

246. Chest wall reconstruction using a combined musculocutaneous anterolateral-anteromedial thigh flap

Author

Pearlie W. W. Tan, Chin-Ho Wong, Heng-Nung Koong, and Bien-Keem Tan

Subjects
anterolateral thigh flap, anteromedial thigh flap, chest wall defects, combined free flap, Surgery, RD1-811
Abstract

We present a massive 25 cm x 20 cm chest wall defect resulting from resection of recurrent cystosarcoma phyllodes of the breast along with six ribs exposing pleura. The chest wall was reconstructed with a Prolene mesh–methylmethacrylate cement sandwich while soft tissue reconstruction was carried out using a combined free anterolateral–anteromedial thigh musculocutaneous flap with two separate pedicles, anastomosed to the thoracodorsal and thoracoacromial vessels respectively. We explain our rationale for and the advantages of combining the musculocutaneous anterolateral thigh flap with the anteromedial-rectus femoris thigh flap.

Published
2010
Full Text
View/download PDF

247. Paleovegetation reconstruction using δ13C of Soil Organic Matter

Author

F. Su, W. Tan, L. Zhou, X. Feng, J. Han, and G. Wang

Subjects
Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract

The relative contributions of C3 and C4 plants to vegetation at a given locality may be estimated by means of δ13C of soil organic matter. This approach holds a great potential for paleoecological reconstruction using paleosols. However, two main uncertainties exist, which limits the accuracy of this application. One is δ13C-enrichment as the plant carbon becomes incorporated into soil organic matter. The other is due to environmental influences on δ13C of plants. Two types of data were collected and analyzed with an objective of narrowing the error of paleovegetation reconstruction. First, we investigated δ13C variations of 557 C3 and 136 C4 plants along a precipitation gradient in North China. A strong negative correlation is found between the δ13C value of C3 plants averaged for each site and the annual precipitation with a coefficient of −0.40‰/100mm, while no significant coefficients were found for C4 plants. Second, we measured δ13C of soil organic matters for 14 soil profiles at three sites. The isotopic difference between vegetation and soil organic matter are evaluated to be 1.8‰ for the surface soil and 2.8‰ for the soil at the bottom of soil profiles. We conducted a sample reconstruction of paleovegetation at the central Chinese Loess Plateau during the Holocene and the Last Glacial (LG), and conclude that, without corrections for δ13C-enrichment by decomposition, the C4 abundance would be overestimated. The importance and uncertainties of other corrections are also discussed.

Published
2008

248. 1506 A human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages

Author

Miaojia Zhang, Linyu Geng, Lingyun Sun, Xue Xu, Gary S. Gilkeson, Yun Deng, Betty P. Tsao, W. Tan, Diane L. Kamen, Lingxiao Xu, Jian Zhao, Xuebing Feng, Phillip Ruiz, Ivan Molano, Quan Zhen Li, and Sang Cheol Bae

Subjects
Genetics, Kidney, medicine.anatomical_structure, Murine lupus, medicine, Cancer research, Biology, Immunologic diseases. Allergy, RC581-607, Efferocytosis
Published
2021

249. Consensus recommendation on the use of therapeutic plasma exchange for adult neurological diseases in Southeast Asia from the Southeast Asia therapeutic plasma exchange consortium

Author

Win Min Thit, Say Saysavath Keosodsay, Sasitorn Siritho, Shanthi Viswanathan, Sing Keat Wong, Ohnmar Ohnmar, Shirley Lee, Riwanti Estiasari, Paul Matthew D. Pasco, Kevin S. W. Tan, Seinn Mya Mya Aye, Hoang Tien Trong Nghia, Umapathi N. Thirugnanam, Mathew Alexander, Badrul Islam, Norazieda Yassin, Fu Liong Hiew, and Anupam Chhabra

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine, Treatment options, Plasmapheresis, Therapeutic plasma exchange, Neurology. Diseases of the nervous system, Intensive care medicine, business, RC346-429, Southeast asia
Abstract

Therapeutic plasma exchange (TPE) is an effective and affordable treatment option in most parts of Southeast Asia (SEA). In 2018, the SEA TPE Consortium (SEATPEC) was established, consisting of regional neurologists working to improve outcome of various autoimmune neurological diseases. We proposed an immunotherapeutic guideline prioritizing TPE for this region. We reviewed disease burden, evidence-based treatment options, and major guidelines for common autoimmune neurological disorders seen in SEA. A modified treatment algorithm based on consensus agreement by key-opinion leaders was proposed. Autoimmune antibody diagnostic testing through collaboration with accredited laboratories was established. Choice of first-line immunotherapies (IVIg/corticosteroid/TPE) is based on available evidence, clinicians’ experience, contraindications, local availability, and affordability. TPE could be chosen as first-line therapy for GBS, CIDP, MG (acute/short term), IgG, A paraproteinemic neuropathy, and NMDAR encephalitis. Treatment is stopped for acute monophasic conditions such as GBS and ADEM following satisfactory outcome. For chronic immune disorders, a therapy taper or long-term maintenance therapy is recommended depending on the defined clinical state. TPE as second-line treatment is indicated for IVIg or corticosteroids refractory cases of ADEM, NMOSD (acute), MG, and NMDAR/LGI1/CASPR2/Hashimoto’s encephalitis. With better diagnosis, treatment initiation with TPE is a sustainable and effective immunotherapy for autoimmune neurological diseases in SEA.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results