342 results on '"Vitelli, M."'
Search Results
202. Impulse performances of cable terminations employing stress grading accessories.
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Petrarca, C., Egiziano, L., Tucci, V., and Vitelli, M.
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- 1999
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203. Numerical evaluation of the electric field in cable terminations equipped with nonlinear grading materials.
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Lupo, G., Petrarca, C., Egiziano, L., Tucci, V., and Vitelli, M.
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- 1998
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204. Investigation on performances of insulation materials for inverter-fed traction motors.
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Petrarca, C., Egiziano, L., Tucci, V., and Vitelli, M.
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- 1998
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205. Electric field calculation in HV cable terminations employing heat-shrinkable composites with non linear characteristics.
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Lupo, G., Tucci, V., Femia, N., and Vitelli, M.
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- 1994
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206. Partial discharge diagnostics on a HV superconducting model cable.
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Lupo, G., Petrarca, C., Egiziano, L., Tucci, V., and Vitelli, M.
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- 1997
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207. Enhancing Polymeric Electrolyte Membrane Fuel Cell Control by Means of the Perturb and Observe Technique
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Giustiniani, A., Petrone, G., Spagnuolo, G., Arsie, I., Di Domenico, A., Pianese, C., Sorrentino, M., and Vitelli, M.
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In this paper, the use of an adaptive technique aimed at controlling a polymeric electrolyte membrane fuel cell is introduced. It is demonstrated that a hill climbing-based method, acting on the compressor speed and/or the cathode back-pressure valve, allows to better take into account the effect of exogenous variables on stack performance. Particularly, the proposed technique has proven to perform better than classical feedforward/feedback approaches when well known aging mechanisms deteriorate cell efficiency. Numerical results based on experimentally derived models confirm the potential of the proposed control method and its intrinsic reliability.
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- 2010
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208. Stochastic thermodynamics of a piezoelectric energy harvester model
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A. Sarracino, Luigi Costanzo, A. Lo Schiavo, Massimo Vitelli, Costanzo, L., Lo Schiavo, A., Sarracino, A., and Vitelli, M.
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Work (thermodynamics) ,Science ,QC1-999 ,FOS: Physical sciences ,General Physics and Astronomy ,Thermodynamics ,Astrophysics ,01 natural sciences ,Article ,010305 fluids & plasmas ,law.invention ,law ,0103 physical sciences ,stochastic thermodynamics ,010306 general physics ,Condensed Matter - Statistical Mechanics ,Physics ,Statistical Mechanics (cond-mat.stat-mech) ,Numerical analysis ,Linear model ,Piezoelectricity ,piezoelectric energy harvester ,work fluctuations ,Vibration ,Langevin equation ,QB460-466 ,Capacitor ,Stochastic thermodynamic ,Resistor - Abstract
We experimentally study a piezoelectric energy harvester driven by broadband random vibrations. We show that a linear model, consisting of an underdamped Langevin equation for the dynamics of the tip mass, electromechanically coupled with a capacitor and a load resistor, can accurately describe the experimental data. In particular, the theoretical model allows us to define fluctuating currents and to study the stochastic thermodynamics of the system, with focus on the distribution of the extracted work over different time intervals. Our analytical and numerical analysis of the linear model is successfully compared to the experiments, 11 pages, 10 figures
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- 2021
209. Optimization of diode bridge rectifier output voltage in Train Suspension Energy Harvesters
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Luigi Costanzo, Lei Zuo, Massimo Vitelli, Alessandro Lo Schiavo, Costanzo, L., Vitelli, M., Lo Schiavo, A., and Zuo, L.
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Maximum Power Point Tracking ,Materials science ,business.industry ,Electrical engineering ,Modelling ,Maximum power point tracking ,Power (physics) ,Generator (circuit theory) ,Rectifier ,Train Suspension Energy Harvesters ,Suspension (vehicle) ,business ,Energy harvesting ,Power Electronics Interface ,Energy (signal processing) ,Voltage - Abstract
This paper is focused on energy harvesting from railcar suspensions. In particular, the power extracted from a train suspension energy harvester based on a mechanical motion rectifier system is evaluated in presence of a passive AC/DC converter. Through a proper theoretical analysis, experimentally validated, it is shown that the extracted power is strictly dependent on the DC side voltage and that the value of the DC voltage at the output of the diode bridge rectifier maximizing the average extracted power is proportional to the generator speed. The above analysis is essential for the proper design of maximum power point tracking techniques.
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- 2020
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210. A Novel MPPT Technique for Single Stage Grid-Connected PV Systems: T4S
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Massimo Vitelli, Luigi Costanzo, Costanzo, L., and Vitelli, M.
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Control and Optimization ,Computer science ,020209 energy ,Irradiance ,Energy Engineering and Power Technology ,02 engineering and technology ,Tracking (particle physics) ,Signal ,Maximum power point tracking ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,Engineering (miscellaneous) ,Photovoltaic system ,Renewable Energy, Sustainability and the Environment ,020208 electrical & electronic engineering ,Grid ,maximum power point tracking ,Power (physics) ,Maximumpower point tracking ,single stage grid connected systems ,photovoltaic systems ,Voltage reference ,Energy (miscellaneous) ,Sign (mathematics) - Abstract
In this paper, a novel maximum power point tracking (MPPT) technique, which has been named T4S (a technique based on the proper setting of the sign of the slope of the photovoltaic voltage reference signal), is presented and discussed. It is specifically designed with reference to a single-stage grid-connected PV system. Its performance is numerically compared with that of the well-known and widely used perturb and observe (P&O) MPPT technique. The results of the numerical simulations confirm the validity of the proposed MPPT technique which exhibited a slightly better performance, under stationary and also time-varying irradiance conditions. In addition, the T4S technique is characterized by the following features: it does not require explicit power detection or calculation and, moreover, it allows the tracking of the maximum average power injected into the grid rather than the tracking of the maximum instantaneous power extracted by the PV source.
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- 2019
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211. Two-Dimensional P&O MPPT Technique for Piezoelectric Vibration Energy Harvesters
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Massimo Vitelli, Luigi Costanzo, ICCEP, Costanzo, L., and Vitelli, M.
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Optimal matching ,piezoelectric Vibration Energy Harvesters ,Computer science ,Maximum Power Point Tracking Technique ,020208 electrical & electronic engineering ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Piezoelectricity ,Maximum power point tracking ,Power (physics) ,Vibration ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,perturb and Observe ,open Circuit Voltage ,0210 nano-technology ,Electrical impedance ,Energy harvesting ,Energy (signal processing) - Abstract
This paper is focused on resonant Piezoelectric Vibration Energy Harvesters (PVEHs). In all energy harvesting applications, and in particular in PVEH applications, the maximization of the extracted power is mandatory. It is well known that, in order to maximize the harvested power, it is necessary to get the optimal matching between the harvesting device and the load. In particular, in PVEH applications under purely sinusoidal input vibrations, in order to maximize the harvested power, the impedance of the load must be coincident with a well-defined optimal impedance ZOPT. However, in practical applications, the load of PVEHs is not a linear impedance, but it is nearly always represented by a non-linear AC/DC converter. In this paper, the full-bridge based active AC/DC architecture, that is theoretically able to emulate just the optimal impedance ZOPT, is analyzed in detail. In particular, a Two-Dimensional Perturb and Observe (TD-P&O) algorithm is proposed and discussed for the emulation of such an optimal impedance. Simulation results confirming the validity of the proposed TD-P&O algorithm and the increase of the extracted power with respect to the simpler case of a diode bridge rectifier source/load electronic interface are presented and discussed.
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- 2019
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212. Modeling piezoelectric harvesters under amplitude and frequency modulated vibrations
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Alessandro Lo Schiavo, Massimo Vitelli, Luigi Costanzo, Costanzo, L., Lo Schiavo, A., and Vitelli, M.
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Physics ,Vibration Energy Harvesters ,Nonlinear circuit analysi ,Acoustics ,020208 electrical & electronic engineering ,010401 analytical chemistry ,Piezoelectric Harvester ,02 engineering and technology ,01 natural sciences ,0104 chemical sciences ,Power (physics) ,Amplitude modulation ,Vibration ,Rectifier ,Amplitude ,0202 electrical engineering, electronic engineering, information engineering ,Energy harvesting ,Frequency modulation ,Modulated Vibration ,Voltage - Abstract
The prediction of the extractable power from energy harvesting devices is of utmost interest for system designers. In this paper, this issue is addressed in the case of Piezoelectric Resonant Vibration Energy Harvesters (PRVEHs) driven by amplitude and frequency modulated vibrations. The widespread architecture of PRVEH systems made up of a passive rectifier cascaded by a DC/DC converter is here considered. An analytical expression of the harvested power as a function of the voltage at the output of the passive rectifier is derived for the cases of vibrations with amplitude modulation and frequency modulation. Further, an analytical-numerical formula is presented for PRVEHs fed by non-sinusoidal vibrations exhibiting envelope and frequency with slow variations. Numerical simulations confirm the theoretical results.
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- 2019
213. Maximizing the power extraction from train suspension energy harvesting system
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Massimo Vitelli, Lei Zuo, Yu Pan, Luigi Costanzo, ASME, Costanzo, L., Vitelli, M., Pan, Y., and Zuo, L.
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Stress (mechanics) ,Power extraction ,Computer science ,Train ,Electronics ,Suspension (vehicle) ,Energy harvesting ,Automotive engineering - Abstract
In this paper, an equivalent electric model for railway vehicle suspension harvester is proposed. With reference to the maximization of the extracted power, the open issues for such kinds of systems are reviewed. In particular, it is evidenced that the use of passive diode bridge rectifiers unavoidably leads to a reduction of power with respect to both the resistive load case and the theoretical optimal load case. Therefore, suitable average power maximization techniques and power electronics architectures are needed. In this paper, two techniques are proposed. The first technique is based on the adoption of additional passive components and, in the considered test cases, it allows the increase of the power output up to 45%. The second technique is based on the adoption of a properly controlled active power electronic interface and it is much more efficient since, in the considered test cases, it allows the increase of the power output up to 135%.
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- 2019
214. Maximum Power Transfer in Electromagnetic Vibration Energy Harvesters driven by Non-Sinusoidal Vibrations
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Massimo Vitelli, Luigi Costanzo, ICCEP, Costanzo, L., and Vitelli, M.
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Physics ,energy harvesting ,Maximum power principle ,maximum power ,020208 electrical & electronic engineering ,02 engineering and technology ,AC power ,021001 nanoscience & nanotechnology ,Power (physics) ,Vibration ,Control theory ,Q factor ,Power electronics ,0202 electrical engineering, electronic engineering, information engineering ,Maximum power transfer theorem ,ComputerSystemsOrganization_SPECIAL-PURPOSEANDAPPLICATION-BASEDSYSTEMS ,0210 nano-technology ,optimization ,Energy (signal processing) - Abstract
In this paper, the problem of the Maximum Power Extraction is discussed with reference to Resonant Electromagnetic Vibration Energy Harvesters driven by non-sinusoidal vibrations. It is well known that, in order to maximize the harvested power in case of purely sinusoidal vibrations, the Maximum Power Transfer Theorem must be exploited. Instead, in case of non-sinusoidal vibrations, the Nonlinear Dynamic Maximum Power Transfer Theorem must be exploited. An active power electronics AC/DC architecture is considered and two different control algorithms are proposed and discussed. They are respectively used for the implementation of the Maximum Power Transfer Theorem and of the Nonlinear Dynamic Maximum Power Transfer Theorem. The differences existing between the two proposed controls techniques in terms of performances and implementation complexity are discussed and analyzed with the help of suitable numerical simulations.
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- 2019
215. The ideal utilization factor: A tool to optimize the energetic performances of resonant electromagnetic vibration energy harvesters
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Massimo Vitelli, Luigi Costanzo, L. Costanzo, M. Vitelli, Costanzo, L., and Vitelli, M.
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Electromagnetic vibration ,Rectifier ,Ideal (set theory) ,Computer science ,Electromagnetic coil ,Energy Harvesting ,Electronic engineering ,Figure of merit ,Utilization factor ,Energy harvesting ,Energy (signal processing) ,Resonant Electromagnetic Vibration Harvester ,Source-Load matching - Abstract
In this paper, the Ideal Utilization Factor (IUF) is presented and discussed with reference to Resonant Electromagnetic Vibration Energy Harvesters (REVEHs). The IUF is an important figure of merit that allows the identification suitable additional non-dissipative components to insert between the REVEH coil and the bridge rectifier. Such components allow improving the actual energetic performances of REVEHs in the frequency regions of practical interest.
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- 2018
216. Resonant electromagnetic vibration harvesters applications: Optimization of P&O MPPT technique parameters
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Luigi Costanzo, Massimo Vitelli, L. Costanzo, M. Vitelli, Costanzo, L., and Vitelli, M.
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Physics ,Resonant Electromagnetic Vibration Harvesters ,020209 energy ,020208 electrical & electronic engineering ,MPPT ,Perturbation (astronomy) ,02 engineering and technology ,Energy harvester ,Maximum power point tracking ,Vibration ,Electromagnetic vibration ,Amplitude ,Control theory ,Duty cycle ,P&O ,Energy Harvesting ,0202 electrical engineering, electronic engineering, information engineering ,Energy harvesting - Abstract
In this paper it is shown that Resonant Electromagnetic Vibration Energy Harvester (REVEH) systems nearly always need to be equipped with suitable MPPT (Maximum average Power Point Tracking) controllers due to the fact that the characteristics of vibrations (frequency, amplitude etc.) change with time. The particular (but frequent) case of Constant Frequency Time Varying Amplitude (CFTVA) vibrations will be considered. In particular, the guidelines for the optimization of the P&O MPPT technique to adopt in REVEH systems in the case of CFTVA vibrations are provided. It is demonstrated that both the sampling frequency íp&o and the amplitude Ad of the P&O duty cycle perturbation need to fulfill suitable inequalities in order to get an efficient REVEH system.
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- 2018
217. Maximum Power Point Tracking Techniques
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Massimo Vitelli, Luigi Costanzo, Marco Balato, Marco Balato, Luigi Costanzo, Massimo Vitelli, Balato, M, and Costanzo, L, and Vitelli, M, Wiley Online Encyclopedia of Electrical and Electronics Engineering, John Wiley & Sons, Balato, M., Costanzo, L., and Vitelli, Massimo
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Power optimizer ,Control theory ,Computer science ,020209 energy ,020208 electrical & electronic engineering ,Photovoltaic system ,0202 electrical engineering, electronic engineering, information engineering ,02 engineering and technology ,Maximum power point tracking - Abstract
An essential objective for many photovoltaic (PV) applications is represented by the so‐called maximum power point tracking (MPPT). Under uniform irradiance and ambient temperature conditions, the power versus voltage characteristic of a PV array is characterized by the presence of a unique point, termed maximum power point (MPP), where the power provided by the array itself attains its maximum value. Any other operating point leads to the extraction of a smaller PV energy. Therefore, in order to avoid the waste of PV energy, the working of the array in its MPP is mandatory. Since the position of the MPP continuously changes in time as a function of irradiance and temperature, it is necessary to continuously track it. Such an objective can be obtained by using proper MPPT control techniques. A large number of papers have appeared in the scientific literature during the last 15 years on the issue of MPPT, and as a result it may be difficult to decide the best technique for a given application. Therefore, this survey may hopefully be beneficial to students, researchers, and practitioners in PV systems. The article overviews the representative PV MPPT algorithms, organized into four main groups. The first group contains the so‐called “hill climbing” techniques, the second group contains the “curve fitting” techniques, the third group contains the “dynamical” techniques, and the fourth group includes all the techniques that do not belong to the first three groups.
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- 2016
218. Resonant electromagnetic vibration energy harvesters: The harvester ideal utilization factor
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Luigi Costanzo, Massimo Vitelli, Marco Balato, Balato, Marco, M., and Costanzo, L., and Vitelli, M. Balato, L. Costanzo, M. Vitelli, Balato, M., Costanzo, L., and Vitelli, M.
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Optimal design ,energy harvesting ,Engineering ,02 engineering and technology ,figure of merit ,safety in rail applications ,Computer Science::Digital Libraries ,Power electronic ,Harmonic analysis ,Bridge circuit ,Diode bridge ,0202 electrical engineering, electronic engineering, information engineering ,Figure of merit ,Piezoelectric harvester ,Motion control ,Electromagnetic vibration ,Electrical impedance ,Electronic circuit ,Physics::Biological Physics ,business.industry ,020208 electrical & electronic engineering ,Electrical engineering ,Rectifying circuits, Diode bridge rectifier ,021001 nanoscience & nanotechnology ,Equivalent-linear ,Piezoelectricity ,Power control ,Vibration ,0210 nano-technology ,business ,Utilization factor, Energy harvesting ,Energy (signal processing) - Abstract
In this paper an important figure of merit is introduced and discussed with reference to electromagnetic vibration energy harvesters which are loaded by diode bridge rectifiers. It is called Harvester Ideal Utilization Factor. It precisely quantifies how close to the optimum the harvester is loaded. Such a figure of merit can be defined not only for electromagnetic but also for piezoelectric harvesters as long as the assumptions which allow the modeling of such vibration harvesters by means of an equivalent linear electric circuit are valid. © 2016 IEEE.
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- 2016
219. A Survey on Mismatching and Aging of PV Modules: The Closed Loop
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Massimo Vitelli, Patrizio Manganiello, Marco Balato, Manganiello, P., Balato, M., Vitelli, M., and Vitelli, Massimo
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Closed loop ,Aging ,Materials science ,Cause-effect ,musculoskeletal, neural, and ocular physiology ,Aging of material ,Delamination ,Photovoltaic system ,Photovoltaic power system ,Photovoltaic effects, Aging mechanism ,Engineering physics ,mismatching ,body regions ,photovoltaic (PV) power system ,PV module ,Control and Systems Engineering ,Photovoltaic module ,Electronic engineering ,PV system, Photovoltaic cell ,Electrical and Electronic Engineering ,PV systems reliability ,Degradation (telecommunications) - Abstract
In this paper, the different aging mechanisms taking place in photovoltaic modules are discussed, and the cause-effect links, which exist among such mechanisms, are evidenced. It is also shown that a closed-loop link exists between aging and mismatching since aging (which is nonuniform by its nature) causes mismatching among cells, whereas mismatching, in turn, mainly due to its thermal effects, leads to nonuniform aging. © 2015 IEEE.
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- 2015
220. On the Interaction of Sodium Dodecyl Sulfate with Oligomers of Poly(Ethylene Glycol) in Aqueous Solution
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Luca Bernazzani, L. Feruglio, Donata Ines Maria Catalano, M Vitelli, Vincenzo Mollica, Silvia Borsacchi, Fioretta Asaro, Paolo Gianni, Bernazzani, L., Borsacchi, S., Catalano, D., Gianni, P., Mollica, V., Vitelli, M., Asaro, Fioretta, and Feruglio, L.
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polimero-tensioattivo ,chemistry.chemical_classification ,Aqueous solution ,Inorganic chemistry ,technology, industry, and agriculture ,Polymer ,SDS ,PEG ,NMR ,tempi di rilassamento ,Surfaces, Coatings and Films ,Hydrophobic effect ,chemistry.chemical_compound ,chemistry ,Pulmonary surfactant ,PEG ratio ,Polymer chemistry ,Materials Chemistry ,Titration ,Physical and Theoretical Chemistry ,Sodium dodecyl sulfate ,Ethylene glycol - Abstract
Isothermal calorimetric titrations of aqueous solutions of poly(ethylene glycol) (PEG) with sodium dodecyl sulfate (SDS) are known to exhibit a peculiar trend consisting of endothermic and exothermic effects. This behavior was explained with the formation of two different mixed micellar aggregates, one characterized by hydrophobic interactions and the second by ion−dipole association. Present NMR measurements on 13C, 1H, and 23Na nuclei do not support the formation of a number of PEG−SDS aggregates characterized by interactions of different nature. Our data are rather in accordance with the initial formation, at low surfactant concentration, of a polymer−surfactant aggregate in which the polymeric chain assumes a strained conformation in order to bind a small micellar cluster. The subsequent growing of the aggregate with increasing surfactant concentration allows the polymer to relax to a more expanded, energetically favored, conformation. Further calorimetric titrations with a set of PEG samples of diffe...
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- 2004
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221. Fast Hybrid MPPT Technique for Photovoltaic Applications: numerical and experimental validation
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Gianluca Aurilio, Marco Balato, GALLO, Daniele, Giorgio Graditi, LANDI, Carmine, LUISO, Mario, VITELLI, Massimo, Gianluca, Aurilio, Marco, Balato, Gallo, Daniele, Giorgio, Graditi, Landi, Carmine, Luiso, Mario, Vitelli, Massimo, Graditi, G., Aurilio, G., Balato, M., Landi, C., and Vitelli, M. Luiso. M.
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Engineering ,Article Subject ,business.industry ,Photovoltaic system ,Voltage inverter ,Experimental validation ,Tracking (particle physics) ,Maximum power point tracking ,Power (physics) ,Control theory ,Electronic engineering ,Inverter ,characterization ,measurement ,Electrical and Electronic Engineering ,business ,Voltage ,PV system - Abstract
In PV applications, under mismatching conditions, it is necessary to adopt a maximum power point tracking (MPPT) technique which is able to regulate not only the voltages of the PV modules of the array but also the DC input voltage of the inverter. Such a technique can be considered a hybrid MPPT (HMPPT) technique since it is neither only distributed on the PV modules of the PV array or only centralized at the input of the inverter. In this paper a new HMPPT technique is presented and discussed. Its main advantages are the high MPPT efficiency and the high speed of tracking which are obtained by means of a fast estimate of the optimal values of PV modules voltages and of the input inverter voltage. The new HMPPT technique is compared with simple HMPPT techniques based on the scan of the power versus voltage inverter input characteristic. The theoretical analysis and the results of numerical simulations are widely discussed. Moreover, a laboratory test system, equipped with PV emulators, has been realized and used in order to experimentally validate the proposed technique. © 2014 Gianluca Aurilio et al.
- Published
- 2014
222. Analysis of ultrawide-band detected partial discharges by means of a multiresolution digital signal-processing method
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Carlo Petrarca, G. Lupo, Pasquale Daponte, Massimo Vitelli, Leopoldo Angrisani, Angrisani, L., Daponte, P., Lupo', Giovanni, Petrarca, C., Vitelli, M., L., Angrisani, P., Daponte, G., Lup, C., Petrarca, Vitelli, Massimo, Petrarca, Carlo, M., Vitelli, Angrisani, Leopoldo, and M., Daponte
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Signal processing ,business.industry ,Signal reconstruction ,Partial Discharges ,Applied Mathematics ,Multiresolution analysis ,Wavelet transform ,Pattern recognition ,Wavelet Transform ,Digital signal processing ,Condensed Matter Physics ,Signal ,Interference (communication) ,Electronic engineering ,Artificial intelligence ,Electrical and Electronic Engineering ,business ,Instrumentation ,Reliability (statistics) ,Mathematics - Abstract
Ultrawide-band detection of partial discharges (PDs) mainly aims at recording the true shape of a PD current signal. It is thus possible to achieve more useful information than that provided by other detection techniques about sources and causes of both PD current signals and the physical processes taking place. However, external interference, reflections, oscillations and stray elements in the measuring circuit may distort the signal being recorded; hence, the information extracted from it might sometimes be meaningless. In the paper, a digital signal-processing method for reliable analysis of ultrawide-band detected PD current signals is proposed. The method, exploiting the multiresolution approach peculiar to the Wavelet Transform, is capable of setting the detected signal free from most disturbances affecting its true shape, thus ensuring the significance of the measurements carried out on the signal itself. After a brief remark about the main features of the Wavelet Transform and its multiresolution approach, the proposed method is described in detail. Experimental results obtained on actual PD current signals are then given in order to highlight the method’s reliability and effectiveness.
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- 2000
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223. Factors limiting the efficiency of DMPPT in PV applications
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Marco Balato, Giovanni Spagnuolo, Nicola FEMIA, Massimo Vitelli, GIOVANNI PETRONE, Balato, M, and Femia, N, and Petrone, G, and Spagnuolo, G, and and Vitelli, M
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PV systems ,DMPPT ,Control theory ,Computer science ,Mismatching ,Photovoltaic system ,Electronic engineering ,Topology (electrical circuits) ,Limiting ,Maximum power point tracking - Abstract
In this paper, the main factors limiting the efficiency of Distributed Maximum Power Point Tracking (DMPPT) in PV applications are analyzed. It is shown why, in a PV system adopting DMPPT and operating under mismatching conditions, it is not always possible to obtain the working of each PV module in its own MPP. Index Terms—PV systems, mismatching, DMPPT.
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- 2011
224. Determinazione della tensione e della corrente di cuscinetto in motori asincroni da trazione alimentati tramite inverter
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L. . Egiziano, B. De Vivo, V. Tucci, M. . Vitelli, LUPO', GIOVANNI, PETRARCA, CARLO, L., Egiziano, B., DE VIVO, G., Lupò, C., Petrarca, V., Tucci, Vitelli, Massimo, Egiziano, L., Lupo', Giovanni, Petrarca, Carlo, B., De Vivo, and Vitelli, M.
- Published
- 2006
225. The influence of coil parameters on the voltage distribution in a machine stator winding fed by a PWM inverter
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G. Lupo, Massimo Vitelli, Carlo Petrarca, Vincenzo Tucci, Lupo', Giovanni, Petrarca, Carlo, Tucci, V., and Vitelli, M.
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Engineering ,Stator ,business.industry ,Electrical engineering ,Line (electrical engineering) ,law.invention ,law ,Electromagnetic coil ,Transmission line ,Equivalent circuit ,Skin effect ,business ,Dimensioning ,Voltage - Abstract
The present paper is dedicated to the evaluation of the influence played by important design parameters like the interturn insulation thickness and the insulating material permittivity on the voltage distribution among the coils of a stator winding fed by a PWM inverter. The system, composed of a feeder cable and a stator winding is modeled and simulated by using multiconductor transmission line theory. A recently developed time-domain equivalent circuit is used to represent the multiconductor line, with losses possibly dependent on frequency, which allows to correctly describe the dielectric losses and the skin-effect in the conductors. The obtained results can offer a broad guideline to design engineers for a suitable dimensioning of the motor insulation.
- Published
- 2002
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226. Effects of docosahexaenoic acid on [Ca(2+)](i) increase induced by doxorubicin in ventricular rat cardiomyocytes
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S. Rossi, Barbara Rinaldi, M. R. Vitelli, Amelia Filippelli, Liberato Berrino, Enza Palazzo, Francesca Rossi, Vitelli, M. R., Filippelli, A, Rinaldi, Barbara, Rossi, Settimio, Palazzo, Enza, Rossi, Francesco, and Berrino, Liberato
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Male ,medicine.medical_specialty ,Fura-2 ,Docosahexaenoic Acids ,Stereochemistry ,Heart Ventricles ,chemistry.chemical_element ,Cell Separation ,Biology ,Calcium ,In Vitro Techniques ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Homeostasis ,General Pharmacology, Toxicology and Pharmaceutics ,Fluorescent Dyes ,Calcium metabolism ,Antibiotics, Antineoplastic ,Endoplasmic reticulum ,Myocardium ,Heart ,General Medicine ,Microfluorimetry ,Rats ,Perfusion ,Endocrinology ,chemistry ,Docosahexaenoic acid ,Doxorubicin ,Caffeine - Abstract
The clinical use of doxorubicin (DXR) is limited by cardiotoxicity partially due to interference with intracellular Ca(2+) homeostasis and involving the activation of the sarcoplasmic reticulum (SR) Ca(2+) release channels. It is known that docosahexaenoic acid (DHA) is able to potentiate the sensitivity of cancer cells to DXR. The aim of our study was to further evaluate the effects of DHA on [Ca(2+)](i) overload induced by DXR in adult rat ventricular cardiomyocytes in order to verify if DHA interferes with DXR-induced cardiotoxicity too. [Ca(2+)](i) was measured by microfluorimetry. Our data demonstrated that 100 microM DXR induced a statistically significant [Ca(2+)](i)-increase in cardiomyocytes perfused with CaCl(2) Krebs solution (from 135.7 +/- 15 nM to 560.2 +/- 49 nM, n = 9, p < 0.01) and with Ca(2+)-free Krebs solution (from 89.3 +/- 15 nM to 551.1 +/- 35 nM, n = 9, p < 0.01). Treatment with 10 microM DHA for 20 min significantly suppressed DXR [Ca(2+)](i)- increase in cells perfused with CaCl(2) Krebs solution (142.3 +/- 12 nM, n = 9, p < 0.01) and in Ca(2+)-free procedures (100.4 +/- 12 nM, n = 9, p < 0.01). Caffeine 10 mM significantly increased [Ca(2+)](i) in cardiomyocytes perfused with CaCl(2) Krebs solution (from 135.7 +/- 15 nM to 979.2 +/- 17.8 nM, n = 9, p < 0.01) and with Ca(2+)-free Krebs solution (from 89.3 +/- 15 nM to 891.1 +/- 30 nM, n = 9, p < 0.01). Treatment with 10 microM DHA for 20 min suppressed caffeine [Ca(2+)](i)-increase in cardiomyocytes perfused with CaCl(2) Krebs solution (174.2 +/- 28 nM, n = 9, p < 0.01) and in Ca(2+)-free procedures (161.9 +/- 34 nM, n = 9, p < 0.01). In conclusion, our results suggest that DHA is able to prevent acute modifications of calcium homeostasis induced by DXR probably interfering with SR Ca(2+) release channels.
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- 2002
227. Multiconductor transmission line analysis of steep-front surges in machine windings
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G. Lupo, Vincenzo Tucci, Massimo Vitelli, Carlo Petrarca, G., Lupò, C., Petrarca, V., Tucci, Vitelli, Massimo, Lupo', Giovanni, Petrarca, Carlo, M., Vitelli, Petrarca, C., Tucci, V., and Vitelli, M.
- Subjects
Engineering ,Stator ,business.industry ,Topology ,Pulse width modulation ,law.invention ,Inductance ,Transmission line ,law ,Electromagnetic coil ,Multiconductor transmission line ,Frequency domain ,Electronic engineering ,Equivalent circuit ,Machine windings ,Time domain ,Electrical and Electronic Engineering ,business ,Induction motor - Abstract
The numerical evaluation of the electrical stress in the line-end coil of the stator winding of a medium voltage motor fed by a pulsed width modulated (PWM) inverter seems to be indispensable for a rational design of the machine. In order to fulfil such a task, the system, composed of a feeder cable and a stator winding, is modelled and simulated by using multi-conductor transmission line theory. The model can take into account the main phenomena occurring along the lines, i.e. the propagation and the reflection, together with the time dispersion introduced by the losses, eventually dependent on the frequency. The multi-conductor transmission line is solved in the time domain by adopting a technique based on the perturbation theory of the spectrum of symmetric matrices, which sensibly decreases the computational effort with respect to the analysis in the frequency domain. Furthermore, an accurate calculation of the characteristic matrices, which contain the cross-sectional information of the line, is performed by means of a FEM package, so taking into account the effective field distribution in the region of interest. The influence of the accurate evaluation of the capacitance and inductance matrices is considered by comparing the numerical results of the proposed model with those obtained by a simple equivalent circuit, frequently adopted in the literature. In order to validate the proposed model, the simulated results are compared with experimental data.
- Published
- 2002
228. MTL Model and FEM Package for the Evaluation of Steep-Front Surges Distribution in Machine Windings
- Author
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Massimo Vitelli, G. Lupo, Carlo Petrarca, Vincenzo Tucci, Lupo', Giovanni, Petrarca, C., Tucci, V., Vitelli, M., G., Lupò, C., Petrarca, V., Tucci, Vitelli, Massimo, Petrarca, Carlo, and M., Vitelli
- Subjects
Finite element method ,Engineering ,business.industry ,Stator ,law.invention ,Inductance ,Transmission line ,law ,Electromagnetic coil ,Control theory ,Electronic engineering ,Inverter ,business ,Ramp generator ,Induction motor - Abstract
The numerical evaluation of the electrical stress in the line-end coil of the stator winding of a medium voltage motor fed by a PWM inverter seems to be indispensable for a rational design of the machine. In order to fulfill such a task, many computer models have been developed, in which the system is generally modeled by connecting an ideal ramp generator (the inverter) with a single transmission line (the cable connecting the inverter to the motor) in series with a Multiconductor Transmission Line (MTL) (the motor winding). Whichever technique is used for solving the MTL equations, one of the main problems consists in the determination of the per-unit-length electrical parameters of the winding, so that simplified methods are often used for their calculation. In the present paper the calculation of capacitance (C) and inductance (L) matrices is performed by means of a Finite Element Method (FEM) package, so taking into account the effective field distribution in the region of interest. We will show how the use of the simplified methods can result in a wrong prediction of the stresses in the insulation. In order to validate the proposed model, the simulated results are compared with experimental data.
- Published
- 2001
229. Numerical analysis of performances of stress grading cable accessories made of different anisotropic composite materials
- Author
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Massimo Vitelli, Vincenzo Tucci, D. Cerbasi, Carlo Petrarca, Petrarca, Carlo, Cerbasi, D., Tucci, V., Vitelli, M., D., Cerbasi, C., Petrarca, V., Tucci, and Vitelli, Massimo
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Materials science ,Magnetoresistance ,Field (physics) ,business.industry ,Numerical analysis ,Structural engineering ,Electric cables ,Stress (mechanics) ,Nonlinear system ,Fiber cable termination ,Anisotropy, Composite materials, Electric fields, Mathematical model ,Composite material ,Anisotropy ,business ,Realization (systems) ,Stress grading composite - Abstract
Stress control tubes made out of composite materials characterized by nonlinear and anisotropic electric properties, are widely adopted for the realization of cable accessories, in order to achieve an efficient stress control. In this paper a numerical model, able to take into account both anisotropy and nonlinearity of stress grading composites, will be used to investigate on the effect of the different properties on the field distribution inside cable terminations.
- Published
- 2000
230. EM fields associated with lightning channels: on the effect of tortuosity and branching
- Author
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Vincenzo Tucci, Carlo Petrarca, Massimo Vitelli, G. Lupo, Lupo', Giovanni, Petrarca, Carlo, V. TUCCI AND M., Vitelli, Petrarca, C., Vitelli, M., Tucci, V., G., Lupò, C., Petrarca, V., Tucci, and Vitelli, Massimo
- Subjects
Electromagnetic field ,Physics ,electromagnetic fields ,business.industry ,Electromagnetic compatibility ,Condensed Matter Physics ,Fractal dimension ,Tortuosity ,Atomic and Molecular Physics, and Optics ,Fractal antenna ,law.invention ,Magnetic field ,Computational physics ,Optics ,Fractal ,law ,Dipole antenna ,Electrical and Electronic Engineering ,business ,lightning - Abstract
Usually the electric and magnetic fields associated with lightning have been computed by assuming the lightning current to be contained in a straight vertical channel of negligible cross section above a flat perfectly conducting plane. Such a model, which does not take into account that real lightning is characterized by tortuosity and branching, is not able to justify the fine structure of the fields radiated by lightning discharges whose time-domain behavior exhibits a jagged shape with remarkable spectral content in several bands of practical interest. In this work the effect of channel tortuosity and branching is investigated by adopting a suitable numerical technique. The discharge channel has been regarded as a fractal antenna whose associated EM field has been evaluated by superimposing the contribution of the single line radiators composing the whole channel. Such a field has been compared with that generated by a simple dipole antenna in order to study the influence of the fractal nature of the channel on the generated EM fields. The relationship between the fractal dimension of the discharge channel and the fractal dimension of the generated time domain EM fields has been considered and the influence played on such a relationship by the distance between EM source and observation point has also been studied by analyzing the fields evaluated at far and close distances.
- Published
- 2000
231. Interpretation and Classification of partial discharges in HV Cryogenic cable termination
- Author
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L. EGIZIANO, C. PETRARCA, V. TUCCI, M. VITELLI, LUPO', GIOVANNI, Egiziano, L., Lupo', Giovanni, Petrarca, C., Tucci, V., and Vitelli, M.
- Published
- 2000
232. Partial discharge diagnostics on 3.3 kV, 1.2 kA IGBT modules
- Author
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B. Cascone, Carlo Petrarca, Massimo Vitelli, L. Fratelli, Petrarca, Carlo, Cascone, B., Fratelli, L., Vitelli, M., B., Cascone, L., Fratelli, C., Petrarca, and Vitelli, Massimo
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Engineering ,business.industry ,medicine.medical_treatment ,Bipolar junction transistor ,Electrical engineering ,Thyristor ,Aging of materials, Electric insulation ,Semiconductor device ,Insulated-gate bipolar transistor ,Traction (orthopedics) ,IGBT ,Reliability (semiconductor) ,Current injection technique ,Partial discharge ,medicine ,business - Abstract
The insulated gate bipolar transistors (IGBT's) are a new class of semiconductor devices which, for their performances in terms of driving, switching behaviour, etc., are nowadays widely adopted in adjustable speed drives and are increasingly replacing traditional components like SCR and GTO thyristors. Large effort is dedicated in the literature in order to investigate on their long term behaviour, which limits their employment in high reliability demanding applications, like railway traction. In the present paper, in order to investigate on the long-term performances of the electrical insulation of such devices, an experimental activity has been carried out on two types of commercial IGBT modules produced by two different manufacturers. The IGBTs have been subjected to typical working cycles occurring in a traction converter and the effect of the application of such stresses has been studied by recording, at different ageing stages, the partial discharge activity occurring in each module. A characterization of the first stages of the ageing process has thus been achieved.
- Published
- 1999
- Full Text
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233. A non linear model for cap and pin insulators equipped with anti-corona coating
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M. Vitelli, G. Lup, Vincenzo Tucci, Luigi Egiziano, Carlo Petrarca, Lupo', Giovanni, Egiziano, L., Petrarca, C., Tucci, V., and Vitelli, M.
- Subjects
Laplace's equation ,Materials science ,Diffusion equation ,Field (physics) ,business.industry ,Mechanics ,engineering.material ,Optics ,Coating ,Electric field ,engineering ,business ,Galerkin method ,Corona discharge ,Voltage - Abstract
In order to study the field distribution in a suspension cap and pin glass insulator covered with an anti-corona layer a numerical procedure has been developed, which relies on the solution of the Laplace equation and the diffusion equation in a two dimensional domain by the Galerkin method. Numerical results concerning the case of applied sinusoidal power frequency voltage are presented and discussed allowing to gain a better understanding of the influence played by the presence of the non linear conducting coating on the electric field distribution.
- Published
- 1999
- Full Text
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234. A Digital Technique Based On The Wavelet Transform For Partial Discharges Analysis
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G. LUP, C. PETRARCA, L. ANGRISANI, M. DAPONTE, VITELLI, Massimo, Lupo', Giovanni, Petrarca, Carlo, Vitelli, M., Angrisani, L., Daponte, M., G., Lup, C., Petrarca, Vitelli, Massimo, L., Angrisani, and M., Daponte
- Subjects
diagnostic ,Partial Discharge ,wavelet transform - Abstract
With ultrawide-band detection of partial discharge (PD) transients the true shape of a PD current pulse can be recorded. It is so possible to achieve more useful information about both sources and causes of PDs and physical processes taking place. However, the recorded signal can be distorted due to external noise, reflections and oscillations, stray elements in the measuring circuit; as a consequence, the extracted information might be meaningless. In this paper a digital technique for a reliable analysis of such PD pulses is suggested. The technique, based on the Wavelet Transform, is able to set the detected pulse free from most of the disturbances affecting its true shape, thus assuring traceability in the measurements carried out on the pulse itself. After a brief remark on theoretical and implementation features of the Wavelet Transform, the proposed technique is described in detail. Experimental results obtained from the application of the proposed technique to actual PD pulses are also given.
- Published
- 1998
235. Numerical evaluation of the electric field in cable terminations equipped with nonlinear grading materials
- Author
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Carlo Petrarca, G. Lupo, M. Vitelli, Luigi Egiziano, Vincenzo Tucci, Petrarca, Carlo, Egiziano, L., Tucci, V., Vitelli, M., and Lupo', Giovanni
- Subjects
Electromagnetic field ,Engineering ,Field (physics) ,business.industry ,Mechanical engineering ,Optical field ,symbols.namesake ,Nonlinear system ,Maxwell's equations ,Electromagnetic field solver ,Electric field ,symbols ,Fiber cable termination ,Electronic engineering ,stress control ,business ,Cable insulation - Abstract
The numerical evaluation of the electric field in a cable termination equipped with stress grading materials, is carried out by adopting a model based on the electro quasi-static approximation of Maxwell equations. In such a model, the different nonlinear electrical properties of the stress grading materials, obtained from experimental investigations, are taken into account. The influence on the electric field distribution of the different characteristics (resistivity vs. applied field) is investigated, in order to draw useful information on proper field control.
- Published
- 1998
236. Field distribution in cable terminations from a Quasi-static Approximation of the Maxwell Equations
- Author
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Vincenzo Tucci, G. Lupo, Massimo Vitelli, G. Miano, G., Lup, G., Miano, V., Tucci, Vitelli, Massimo, Lupo', Giovanni, Miano, Giovanni, Tucci, V., and Vitelli, M.
- Subjects
Physics ,Laplace's equation ,Field (physics) ,Mathematical analysis ,Finite difference ,Finite difference method ,Nonlinear system ,symbols.namesake ,Maxwell's equations ,Electronic engineering ,symbols ,Boundary value problem ,Electrical and Electronic Engineering ,Galerkin method - Abstract
A new model for the evaluation of the electric field in a cable termination realized through a nonlinear stress control tube (SCT), is presented in this paper. It is based on the electro-quasistatic approximation of the Maxwell equations: the Laplace equation describes the field in the nonconducting regions whereas a diffusion-like equation gives the field dynamics in the stress control tube. A numerical model is devised by solving the Laplace equation by finite difference and diffusion equations by the Galerkin method. It is shown that even the well-known RC transmission line model can be derived from this general approach. The underlying approximations leading to the circuital model are discussed in detail. The proposed model, in contrast with the circuital one, allows us to take into account properly the nonlinear SCT characteristics and the actual boundary conditions: in this way both spatial and temporal effects of the nonlinearity are considered. The numerical results obtained by considering the general field approach and by using the transmission line model are compared.
- Published
- 1996
237. Design and experiments on vacuum bushings for HV apparatuses
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G. LUPO', C. PETRARCA, G. SPAGNUOLO, V. TUCCI, VITELLI, Massimo, Spagnuolo, G., Tucci, V., Lupo', Giovanni, Petrarca, Carlo, Vitelli, M., G., Lupo', C., Petrarca, G., Spagnuolo, V., Tucci, and Vitelli, Massimo
- Subjects
vacuum insulation ,High Voltage - Abstract
An accurate knowledge of the potential and tangential electrical field distribution along the interface insulator-vacuum is required for determining the mechanism leading to the flashover and, practically, for the optimisation of the design of the insulator profile. In this paper a comparison has been carried out between results obtained by numerical methods (Finite Difference Method and Charge Simulation Method) and the basic support they are able to give for the insulator design is also presented. A cylindrical chamfered profile is studied: good accordance is found for the results of the two methods provided the choice of the mesh and fictitious charge distribution is optimised.Some experimental results are also presented which indicate the effectiveness of the adopted insulator profile.
- Published
- 1995
238. Steep-fronted overvoltages in inverter-fed induction motors: Numerical identification of critical parameters
- Author
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Massimo Vitelli, Vincenzo Tucci, Carlo Petrarca, G. Lupo, Luigi Egiziano, L., Egiziano, G., Lup, C., Petrarca, V., Tucci, Vitelli, Massimo, Petrarca, Carlo, Lupo', Giovanni, Egiziano, L., Tucci, V., and Vitelli, M.
- Subjects
Engineering ,business.industry ,Stator ,Electrical engineering ,law.invention ,Control theory ,law ,Electromagnetic coil ,Partial discharge ,Inverter ,business ,Dimensioning ,Pulse-width modulation ,Induction motor ,Voltage - Abstract
Due to the recent trends in power-systems, steep-fronted switching surges are often encountered in many applications as, for example, in induction motors fed by pulse-width modulated (PWM) inverters. In such a case, the effect of these voltage transients can result in undesirable electrical and thermal stresses in the stator windings, which can lead to the premature failure of the insulating material between the coils and, definitely, to the failure of the whole component. Up to now, the dimensioning of the interturn insulation of such motors is based empirically on previous service experience; a more rational design can be performed if a more exact knowledge of the voltage distribution within the stator winding is reached. In the present paper the first results of a simulation carried out in order to predict the voltage distribution between the coils of a stator winding fed by a PWM inverter are presented. Such distributions depend on a very large number of parameters (insulation dimension, coils size, length of connecting cable, shape of the applied voltage, etc.). In the following the influence played on such distribution by the cable length and applied voltage rise-time is discussed.
239. Partial discharge testing on resin insulated voltage transformers
- Author
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Massimo Vitelli, Vincenzo Tucci, G. Lupo, Luigi Egiziano, Carlo Petrarca, Lupo', Giovanni, Petrarca, Carlo, Egiziano, L., Tucci, V., and Vitelli, M.
- Subjects
Engineering ,business.industry ,Applied Mathematics ,Electrical engineering ,resin insulated transformers ,Electric discharge in gases ,law.invention ,Electric field stress ,partial discharge ,law ,Electric field ,Bushing ,Partial discharge ,Ultimate failure ,Electrical and Electronic Engineering ,Composite material ,business ,Transformer ,Voltage - Abstract
The lifetime of resin insulated voltage transformers (RIVT) can be considerably shortened due to partial discharge activity taking place inside the insulation close to the active parts of the component. In that region the presence of voids, due to manufacturing processes, and the enhanced electric field stress lead to an intense partial discharge activity which determines accelerated degradation processes and eventually the ultimate failure of the device. Partial discharge measurements together with an estimation of the electric field distribution in RIVT seem to be indispensable in order to fully understand transformer performances. In this paper, a study of the electric field distribution inside the RIVT, together with results of partial discharge tests are presented. The influence of the various test arrangements and methods on the experimental results are investigated.
240. Impulse performances of cable terminations employing stress grading accessories
- Author
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Massimo Vitelli, Luigi Egiziano, Carlo Petrarca, Vincenzo Tucci, Petrarca, Carlo, Egiziano, L., Tucci, V., and Vitelli, M.
- Subjects
Carbon black, Electric conductivity, Electric properties, Mathematical models, Permittivity, Polyolefins, Spatial variables control, Voltage distribution measurement ,Electric connectors ,Engineering ,business.industry ,Power frequency ,Acoustics ,Cold shrink technology, Ethylene propylene diene monomer, Heat shrinking technology, Sinusoidal power frequency, Stress control tube ,Impulse (physics) ,Nonlinear system ,Stress control ,Electric field ,Electronic engineering ,Fiber cable termination ,Electric properties ,business ,Voltage - Abstract
Stress control tubes (SCTs), made out of materials characterized by nonlinear electric properties, are widely adopted for the realization of cable terminations, in order to achieve a significant stress control. The influence played on the electric field distribution around the cable termination by SCTs parameters (e.g. length, thickness and position) has been studied only in the case of sinusoidal power frequency applied voltage, while no data can be found in the literature concerning applied standard impulse voltages. The purpose of this paper is to investigate on such interesting aspect by evaluating the potential distributions taking place under impulse voltages in cable terminations characterized by different arrangements of the SCT.
241. Modeling the effect of oxidative stress on Bordetella pertussis fermentations.
- Author
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Vitelli M, Tamer IM, Pritzker M, and Budman H
- Subjects
- Glutamic Acid metabolism, Kinetics, NADP metabolism, Reactive Oxygen Species metabolism, Reproducibility of Results, Bordetella pertussis cytology, Bordetella pertussis growth & development, Bordetella pertussis metabolism, Fermentation, Models, Biological, Oxidative Stress
- Abstract
A mathematical model is proposed for Bordetella pertussis with the main goal to better understand and describe the relation between cell growth, oxidative stress and NADPH levels under different oxidative conditions. The model is validated with flask experiments conducted under different conditions of oxidative stress induced by high initial glutamate concentrations, low initial inoculum and secondary culturing following exposure to starvation. The model exhibited good accuracy when calibrated and validated for the different experimental conditions. From comparisons of model predictions to data with different model mechanisms, it was concluded that intracellular reactive oxidative species only have an indirect effect on growth rate by reacting with NADPH and thereby reducing the amount of NADPH that is available for growth., (© 2023 The Authors. Biotechnology Progress published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.)
- Published
- 2023
- Full Text
- View/download PDF
242. Stochastic Thermodynamics of an Electromagnetic Energy Harvester.
- Author
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Costanzo L, Lo Schiavo A, Sarracino A, and Vitelli M
- Abstract
We study the power extracted by an electromagnetic energy harvester driven by broadband vibrations. We describe the system with a linear model, featuring an underdamped stochastic differential equation for an effective mass in a harmonic potential, coupled electromechanically with the current in the circuit. We compare the characteristic curve (power vs. load resistance) obtained in experiments for several values of the vibration amplitude with the analytical results computed from the model. Then, we focus on a more refined analysis, taking into account the temporal correlations of the current signal and the fluctuations of the extracted power over finite times. We find a very good agreement between the analytical predictions and the experimental data, showing that the linear model with effective parameters can describe the real system, even at the fine level of fluctuations. Our results could be useful in the framework of stochastic thermodynamics applied to energy harvesting systems.
- Published
- 2022
- Full Text
- View/download PDF
243. Applications of flow cytometry sorting in the pharmaceutical industry: A review.
- Author
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Vitelli M, Budman H, Pritzker M, and Tamer M
- Subjects
- Cell Separation, Flow Cytometry, Humans, Drug Industry, High-Throughput Screening Assays
- Abstract
The article reviews applications of flow cytometry sorting in manufacturing of pharmaceuticals. Flow cytometry sorting is an extremely powerful tool for monitoring, screening and separating single cells based on any property that can be measured by flow cytometry. Different applications of flow cytometry sorting are classified into groups and discussed in separate sections as follows: (a) isolation of cell types, (b) high throughput screening, (c) cell surface display, (d) droplet fluorescent-activated cell sorting (FACS). Future opportunities are identified including: (a) sorting of particular fractions of the cell population based on a property of interest for generating inoculum that will result in improved outcomes of cell cultures and (b) the use of population balance models in combination with FACS to design and optimize cell cultures., (© 2021 American Institute of Chemical Engineers.)
- Published
- 2021
- Full Text
- View/download PDF
244. A Diagnosis Can Hide Another: The Value of Brain Biopsy in Neurological Lesion of HIV Patients.
- Author
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Vitelli M, Malaizé H, Bielle F, Le Joncour A, Amelot A, Pineton de Chambrun M, and Mathon B
- Subjects
- Adult, Brain diagnostic imaging, Female, Humans, Male, Middle Aged, Transgender Persons, Biopsy methods, Brain pathology, HIV Infections pathology
- Published
- 2021
- Full Text
- View/download PDF
245. Embryo/larval toxicity and transcriptional effects in zebrafish (Danio rerio) exposed to endocrine active riverbed sediments.
- Author
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Viganò L, Casatta N, Farkas A, Mascolo G, Roscioli C, Stefani F, Vitelli M, Olivo F, Clerici L, Robles P, and Dellavedova P
- Subjects
- Animals, Embryo, Nonmammalian, Endocrine System, Geologic Sediments, Larva, Rivers, Water Pollutants, Chemical analysis, Zebrafish
- Abstract
Sediment toxicity plays a fundamental role in the health of inland fish communities; however, the assessment of the hazard potential of contaminated sediments is not a common objective in environmental diagnostics or remediation. This study examined the potential of transcriptional endpoints investigated in zebrafish (Danio rerio) exposed to riverbed sediments in ecotoxicity testing. Embryo-larval 10-day tests were conducted on sediment samples collected from five sites (one upstream and four downstream of the city of Milan) along a polluted tributary of the Po River, the Lambro River. Sediment chemistry showed a progressive downstream deterioration in river quality, so that the final sampling site showed up to eight times higher concentrations of, for example, triclosan, galaxolide, PAH, PCB, BPA, Ni, and Pb, compared with the uppermost site. The embryo/larval tests showed widespread toxicity although the middle river sections evidenced worse effects, as evidenced by delayed embryo development, hatching rate, larval survival, and growth. At the mRNA transcript level, the genes encoding biotransformation enzymes (cyp1a, gst, ugt) showed increasing upregulations after exposure to sediment from further downstream sites. The genes involved in antioxidant responses (sod, gpx) suggested that more critical conditions may be present at downstream sites, but even upstream of Milan there seemed to be some level of oxidative stress. Indirect evidences of potential apoptotic activity (bcl2/bax < 1) in turn suggested the possibility of genotoxic effects. The genes encoding for estrogen receptors (erα, erβ1, erβ2) showed exposure to (xeno)estrogens with a progressive increase after exposure to sediments from downstream sites, paralleled by a corresponding downregulation of the ar gene, likely related to antiandrogenic compounds. Multiple levels of thyroid disruption were also evident particularly in downstream zebrafish, as for thyroid growth (nkx2.1), hormone synthesis and transport (tg, ttr, d2), and signal transduction (trα, trβ). The inhibition of the igf2 gene reasonably reflected larval growth inhibitions. Although none of the sediment chemicals could singly explain fish responses, principal component analysis suggested a good correlation between gene transcripts and the overall trend of contamination. Thus, the combined impacts from known and unknown covarying chemicals were proposed as the most probable explanation of fish responses. In summary, transcriptional endpoints applied to zebrafish embryo/larval test can provide sensitive, comprehensive, and timeliness information which may greatly enable the assessment of the hazard potential of sediments to fish, complementing morphological endpoints and being potentially predictive of longer studies.
- Published
- 2020
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- View/download PDF
246. [Wood manufacture and dioxins: a case prospective study on maintenance of boilers powered by wood chips and shavings].
- Author
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Vitelli M and Paciaccioni D
- Subjects
- Dust, Female, Humans, Incineration methods, Italy, Male, Prospective Studies, Refuse Disposal, Risk Assessment, Wood chemistry, Dioxins poisoning, Occupational Exposure analysis, Wood poisoning
- Abstract
Objectives: to verify if a carpenter using wood scraps, treated or not, to operate the heating system may involve an exposure to dioxins in a given target of workers., Design: the research was structured on literature sources analysis, study on field of the most relevant exposure, occurs through sampling. The results were recorded and plotted, and compared with the data available in literature., Setting and Participants: the study has involved maintenance workers of the heating system by means of wood refuse incineration. These workers were informed of the methods and aims of the sample., Main Outcome Measures: the results confirm a potential exposure to ash containing dioxins, presumably also in other similar situations, in this case not even evaluated by the employer., Results: the average exposure to the light ash during the maintenance operations of the plant dust abatement in emissive phase is about 5 mg/m(3), with a consequent exposure to dioxins inferred, at about 20 pg., Conclusion: operators are exposed to dioxins: this implies that in some operations it is crucial to review the risk assessment and consequently the measures on prevention and health protection to activate.
- Published
- 2014
247. Reconstruction of artery wall in experimental giant aneurysms.
- Author
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Donzelli R, Mariniello G, Vitelli M, Capone C, Sgulò F, Dones F, and Maiuri F
- Subjects
- Adventitia surgery, Angiography, Animals, Blood Loss, Surgical prevention & control, Carotid Arteries diagnostic imaging, Disease Models, Animal, Intracranial Aneurysm diagnostic imaging, Jugular Veins diagnostic imaging, Rabbits, Severity of Illness Index, Suture Techniques, Carotid Arteries surgery, Intracranial Aneurysm surgery, Jugular Veins transplantation, Plastic Surgery Procedures methods, Vascular Surgical Procedures methods
- Abstract
Aim: This study describes five experimental techniques for the surgical treatment of giant aneurysms based on the resection of the aneurysm sac and reconstruction of the arterial wall., Methods: The aneurysm was realized with a venous graft implanted with end-to-side anastomosis on the common carotid artery on 50 rabbits (with each technique realized in 10 rabbits). The first two experimental techniques (A and B) involve the reconstruction of the artery wall by a synthetic dural patch and by direct suture reinforced by a venous patch, respectively. In the model C a collateral branch arising from the aneurysm is resected and reimplanted on the parent artery after aneurysm resection. In the experimental model D the arterial defect is closed by a venous patch surrounding the whole arterial wall and sutured with the aid of fibrin glue. In the model E clamping of the parent artery proximal to the aneurysm site and termino-lateral anastomosis with the contralateral artery lead to the thrombosis of the aneurysm fulled only by refluent flow., Results and Conclusion: The venous pouch experimental models are useful to realize giant aneurysms. The above described techniques allow to realize the reconstruction of the arterial wall without stenosis and shortening the clamping time.
- Published
- 2014
248. [Wood dusts and neoplasms of the nose and paranasal sinuses: field investigations and laboratory experiments].
- Author
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Vitelli M and Sarrini D
- Subjects
- Construction Materials, Hot Temperature adverse effects, Humans, Italy, Paranasal Sinus Neoplasms chemically induced, Particulate Matter adverse effects, Risk Factors, Dust, Nose Neoplasms chemically induced, Occupational Exposure adverse effects, Wood adverse effects
- Abstract
Nose and paranasal sinus cancers are among the diseases related to exposure to wood dusts. The aim of this study was to evaluate exposure to hardwood dust by workers in small carpentry industries in central Italy (Tuscany, Italy) employing from one to ten workers each, and to investigate pathogenetic mechanisms. The efficacy of ventilation systems was assessed and exposure levels determined. Exposure conditions of hardwood workers were then reproduced in the laboratory and a physical/kinetic model prepared to simulate patterns of air uptake by workers. Various parameters were then measured to investigate possible risk factors that may be related to the onset of the disease. In addition to particle size of wood dust, a factor that requires further investigation is the temperatures reached by wood dust during processing, which may lead to the formation of new harmful molecules.
- Published
- 2013
249. Introduction, establishment, and potential geographic range of Carmenta sp. nr ithacae (Lepidoptera: Sesiidae), a biological control agent for Parthenium hysterophorus (Asteraceae) in Australia.
- Author
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Dhileepan K, Trevino M, Vitelli MP, Senaratne KA, McClay AS, and McFadyen RE
- Subjects
- Animals, Geography, Larva growth & development, Life Cycle Stages, Models, Theoretical, Queensland, Asteraceae physiology, Biological Control Agents, Environment, Moths physiology
- Abstract
Parthenium (Parthenium hysterophorus L.), a major weed causing economic, environmental, and human and animal health problems in Australia and several countries in Asia, Africa, and the Pacific, has been a target for biological control in Australia since the mid-1970s. Nine species of insects and two rust fungi have been introduced as biological control agents into Australia. These include Carmenta sp. nr ithacae, a root feeding agent from Mexico. The larvae of C. sp. nr ithacae bore through the stem-base into the root where they feed on the cortical tissue of the taproot. During 1998-2002, 2,816 larval-infested plants and 387 adults were released at 31 sites across Queensland, Australia. Evidence of field establishment was first observed in two of the release sites in central Queensland in 2004. Annual surveys at these sites and nonrelease sites during 2006-2011 showed wide variations in the incidence and abundance of C. sp. nr ithacae between years and sites. Surveys at three of the nine release sites in northern Queensland and 16 of the 22 release sites in central Queensland confirmed the field establishment of C. sp. nr ithacae in four release sites and four nonrelease sites, all in central Queensland. No field establishment was evident in the inland region or in northern Queensland. A CLIMEX model based on the native range distribution of C. sp. nr ithacae predicts that areas east of the dividing range along the coast are more suitable for field establishment than inland areas. Future efforts to redistribute this agent should be restricted to areas identified as climatically favorable by the CLIMEX model.
- Published
- 2012
- Full Text
- View/download PDF
250. Self-prescribed laxative use: a drug-utilization review.
- Author
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Motola G, Mazzeo F, Rinaldi B, Capuano A, Rossi S, Russo F, Vitelli MR, Rossi F, and Filippelli A
- Subjects
- Adolescent, Adult, Aged, Cathartics adverse effects, Constipation drug therapy, Constipation etiology, Data Collection, Drug Utilization, Female, Humans, Italy, Male, Middle Aged, Nonprescription Drugs adverse effects, Cathartics therapeutic use, Nonprescription Drugs therapeutic use, Self Medication
- Abstract
This study was conducted to determine the reasons for the choice of self-prescribed laxatives and to acquire information on how they were used and tolerated. From November 1999 to February 2000, 70 pharmacies, uniformly located throughout the Campania region of southern Italy, distributed a questionnaire to purchasers of over-the-counter laxatives. The average age of the (mostly female) respondents was 45.9 years; 23.8% were elderly. Among the 7324 individuals who completed the survey, 77.6% selected an oral product; 22.4% preferred rectal administration. A physician influenced the choice of a laxative in 37.7% of the cases, a pharmacist in 20.5%; other suggestions came from relatives (14%), acquaintances (12.1%), advertisements (11.7%), and miscellaneous sources (4%). Only 59.8% of respondents used these drugs correctly, and 58.2% consulted a physician or pharmacist because of constipation. Adverse effects, mainly gastrointestinal symptoms, occurred in 6.1% of those surveyed. The long-term use or abuse of laxatives can cause serious medical consequences, as well as mask diseases, delaying diagnosis and appropriate treatment. Physicians, pharmacists, and other health-care personnel should counsel patients on the proper use of these easily available, ubiquitous drugs.
- Published
- 2002
- Full Text
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