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661 results on '"Villani, Claudio"'

201. Direct HPLC separation of beta-aminoester enantiomers on totally synthetic chiral stationary phases

Author

Gasparrini, Francesco, D'Acquarica, Ilaria, Villani, Claudio, Cimarelli, C., and Palmieri, G.

Subjects
Cyclohexylamines, Esters, Stereoisomerism, ENOLATE IMINE CONDENSATION, ENANTIOSELECTIVE SYNTHESIS, ASYMMETRIC-SYNTHESIS, TRANS-1, 2-DIAMINOCYCLOHEXANE DERIVATIVES, ALPHA, BETA-UNSATURATED ESTERS, CONVENIENT SYNTHESIS, MICHAEL ADDITIONS, ENAMINO ESTERS, TMS-SAMP, ACIDS, Amino Acids, Chromatography, High Pressure Liquid
Abstract

The direct separation of beta-aminoester enantiomers by HPLC on synthetic chiral stationary phases based on a pi-acidic derivative of trans 1,2-diaminocyclohexane as selector is described. The application of different columns containing the stationary phase with opposite configurations and in the racemic form to the determination of enantiomeric excess in chemically impure samples is demonstrated.

Published
1997

208. Introducing Enantioselective Ultrahigh-Pressure Liquid Chromatography (eUHPLC): Theoretical Inspections and Ultrafast Separations on a New Sub-2-μm Whelk-O1 Stationary Phase

Author

Kotoni, Dorina, primary, Ciogli, Alessia, additional, Molinaro, Carmela, additional, D’Acquarica, Ilaria, additional, Kocergin, Jelena, additional, Szczerba, Ted, additional, Ritchie, Harald, additional, Villani, Claudio, additional, and Gasparrini, Francesco, additional

Published
2012
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210. Organic stereochemistry and enantioconformational analysis from chiral chromatography and DNMR measurements

Author

Gasparrini, Francesco, Lunazzi, L., Misiti, Domenico, and Villani, Claudio

Subjects
SUPERCRITICAL-FLUID-CHROMATOGRAPHY, PERFORMANCE LIQUID-CHROMATOGRAPHY, COMPLEXATION GAS-CHROMATOGRAPHY, CHIRAL STATIONARY PHASES, NMR-SPECTROSCOPY, TRANS-1, 2-DIAMINOCYCLOHEXANE DERIVATIVES, ENANTIOMERIZATION BARRIER, INTERCONVERSION PROFILES, THERMAL INTERCONVERSION, CHIROPTICAL DETECTION
Published
1995

211. Atropisomerism in hindered naphthyl sulfones

Author

Casarini, D., Lunazzi, L., Alcaro, S., Gasparrini, Francesco, and Villani, Claudio

Subjects
Nuclear magnetic resonance spectrometry, Sulfones, Molecular mechanics, Conformation and Conformers, HPLC
Published
1995

212. Erratum to “Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry” [J. Chromatogr. A 1218 (2011) 3862–3875]

Author

Badaloni, Elena, primary, Barbarino, Marcella, additional, Cabri, Walter, additional, D’Acquarica, Ilaria, additional, Forte, Michela, additional, Gasparrini, Francesco, additional, Giorgi, Fabrizio, additional, Pierini, Marco, additional, Simone, Patrizia, additional, Ursini, Ornella, additional, and Villani, Claudio, additional

Published
2011
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217. Stereolability of Dihydroartemisinin, an Antimalarial Drug: A Comprehensive Thermodynamic Investigation. Part 1

Author

Cabri, Walter, primary, D’Acquarica, Ilaria, additional, Simone, Patrizia, additional, Di Iorio, Marta, additional, Di Mattia, Michela, additional, Gasparrini, Francesco, additional, Giorgi, Fabrizio, additional, Mazzanti, Andrea, additional, Pierini, Marco, additional, Quaglia, Marco, additional, and Villani, Claudio, additional

Published
2011
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225. Stereoselective Behavior of the Functional Diltiazem Analogue 1-[(4-Chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a New L-Type Calcium Channel Blocker

Author

Carosati, Emanuele, primary, Budriesi, Roberta, additional, Ioan, Pierfranco, additional, Cruciani, Gabriele, additional, Fusi, Fabio, additional, Frosini, Maria, additional, Saponara, Simona, additional, Gasparrini, Francesco, additional, Ciogli, Alessia, additional, Villani, Claudio, additional, Stephens, Philip J., additional, Devlin, Frank J., additional, Spinelli, Domenico, additional, and Chiarini, Alberto, additional

Published
2009
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236. Chiral alpha-substituted alpha-aryloxy acetic acids: synthetis, absolute configuration, chemical resolution and direct separation by HPLC

Author

Bettoni, G., Ferorelli, S., Loiodice, F., Tangari, N., Tortorella, V., Gasparrini, Francesco, Misiti, Domenico, and Villani, Claudio

Subjects
ARYLOXYACETIC ACIDS, CHIRAL RECOGNITION, ENANTIOMERS, CHIRAL PHASE, MYOTONIA, OPTICAL ROTATORY DISPERSION, CIRCULAR DICHROISM, BIOLOGICAL STEREOSPECIFICITY, ENANTIOMERS, CHIRAL PHASE, CHIRAL RECOGNITION, ARYLOXYACETIC ACIDS, OPTICAL ROTATORY DISPERSION, CIRCULAR DICHROISM, BIOLOGICAL STEREOSPECIFICITY, MYOTONIA
Published
1992

238. Diastereomer Interconversion via.

Author

Renzetti, Andrea, Di Crescenzo, Antonello, Nie, Feilin, Bond, Andrew D., Gérard, Stéphane, Sapi, Janos, Fontana, Antonella, and Villani, Claudio

Subjects
CRYSTALLIZATION, HIGH performance liquid chromatography, DIASTEREOISOMERS, THERMODYNAMICS research, CHIRALITY
Abstract

The three-component reaction of indole, isobutyraldehyde, and methyl acetoacetate affords methyl 2-(acetyl)-3-(1 H-indol-3-yl)-4-methylpentanoate as a single diastereomer. To investigate the origin of the observed diastereoselectivity, the thermodynamics and kinetics of interconversion of diastereomers 1 and 2 in solution were studied by a combination of 1H (NMR) spectroscopy, high-performance (HPLC), , and experiments. The results indicate that interconversion is both acid- and base-catalyzed, and that the alpha carbon is the only stereolabile center in the molecule. The evidence points to an mechanism for the interconversion process. The selective precipitation of 1 in the presence of the equilibrium 1⇆ 2 eventually results in the exclusive formation of 1 (crystallization-induced asymmetric transformation). Chirality 27:779-783, 2015. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2015
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239. Polyaspartamide-Doxorubicin Conjugate as Potential Prodrug for Anticancer Therapy.

Author

Meo, Chiara, Cilurzo, Felisa, Licciardi, Mariano, Scialabba, Cinzia, Sabia, Rocchina, Paolino, Donatella, Capitani, Donatella, Fresta, Massimo, Giammona, Gaetano, Villani, Claudio, and Matricardi, Pietro

Subjects
DOXORUBICIN, BIOCONJUGATES, PRODRUGS, ANTINEOPLASTIC agents, COPOLYMERS, AMINO group, THERAPEUTICS
Abstract

Purpose: To synthesize a new polymeric prodrug based on α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-d,l-aspartamide copolymer bearing amine groups in the side chain (PHEA-EDA), covalently linked to the anticancer drug doxorubicin and to test its potential application in anticancer therapy. Methods: The drug was previously derivatized with a biocompatible and hydrophilic linker, leading to a doxorubicin derivative highly reactive with amino groups of PHEA-EDA. The PHEA-EDA-DOXO prodrug was characterized in terms of chemical stability. The pharmacokinetics, biodistribution and cytotoxicity of the product was investigated in vitro and in vivo on human breast cancer MCF-7 and T47D cell lines and NOD-SCID mice bearing a MCF-7 human breast carcinoma xenograft. Data collected were compared to those obtained using free doxorubicin. Results: The final polymeric product is water soluble and easily hydrolysable in vivo, due to the presence of ester and amide bonds along the spacer between the drug and the polymeric backbone. In vitro tests showed a retarded cytotoxic effect on tumor cells, whereas a significant improvement of the in vivo antitumor activity of PHEA-EDA-DOXO and a survival advantage of the treated NOD-SCID mice was evidenced, compared to that of free doxorubicin. Conclusions: The features of the PHEA-EDA-DOXO provide a potential protection of the drug from the plasmatic enzymatic degradation and clearance, an improvement of the blood pharmacokinetic parameters and a suitable body biodistribution. The data collected support the promising rationale of the proposed macromolecular prodrug PHEA-EDA-DOXO for further potential development and application in the treatment of solid cancer diseases. [ABSTRACT FROM AUTHOR]

Published
2015
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241. Carbon nanotubes on HPLC silica microspheres

Author

Menna, Enzo, primary, Negra, Federico Della, additional, Prato, Maurizio, additional, Tagmatarchis, Nikos, additional, Ciogli, Alessia, additional, Gasparrini, Francesco, additional, Misiti, Domenico, additional, and Villani, Claudio, additional

Published
2006
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