901 results on '"Verdonck-de Leeuw, Irma M"'
Search Results
202. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients: which groups specifically benefit? Secondary analyses of a randomized controlled trial
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MS Hoofd-Hals Chirurgische Oncologie, Cancer, Jansen, Femke, Lissenberg-Witte, Birgit I, Krebber, Anna M H, Cuijpers, Pim, de Bree, Remco, Becker-Commissaris, Annemarie, Smit, Egbert F, van Straten, Annemieke, Eeckhout, Guus M, Beekman, Aartjan T F, Leemans, C René, Verdonck-de Leeuw, Irma M, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Jansen, Femke, Lissenberg-Witte, Birgit I, Krebber, Anna M H, Cuijpers, Pim, de Bree, Remco, Becker-Commissaris, Annemarie, Smit, Egbert F, van Straten, Annemieke, Eeckhout, Guus M, Beekman, Aartjan T F, Leemans, C René, and Verdonck-de Leeuw, Irma M
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- 2019
203. Assessment of Neurocognitive Impairment and Speech Functioning Before Head and Neck Cancer Treatment
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MS Radiotherapie, Cancer, Piai, Vitoria, Prins, Judith B., Verdonck-de Leeuw, Irma M., Leemans, C. Rene, Terhaard, Chris H. J., Langendijk, Johannes A., de Jong, Robert J. Baatenburg, Smit, Johannes H., Takes, Robert P., Kessels, Roy P. C., MS Radiotherapie, Cancer, Piai, Vitoria, Prins, Judith B., Verdonck-de Leeuw, Irma M., Leemans, C. Rene, Terhaard, Chris H. J., Langendijk, Johannes A., de Jong, Robert J. Baatenburg, Smit, Johannes H., Takes, Robert P., and Kessels, Roy P. C.
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- 2019
204. Development and Psychometric Evaluation of an Item Bank for Computerized Adaptive Testing of the EORTC Insomnia Dimension in Cancer Patients (EORTC CAT-SL)
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Dirven, Linda, Petersen, Morten Aa, Aaronson, Neil K., Chie, Wei-Chu, Conroy, Thierry, Costantini, Anna, Hammerlid, Eva, Velikova, Galina, Verdonck-de Leeuw, Irma M., Young, Teresa, Grønvold, Mogens, Dirven, Linda, Petersen, Morten Aa, Aaronson, Neil K., Chie, Wei-Chu, Conroy, Thierry, Costantini, Anna, Hammerlid, Eva, Velikova, Galina, Verdonck-de Leeuw, Irma M., Young, Teresa, and Grønvold, Mogens
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- 2019
205. Measuring health-related quality of life in colorectal cancer patients:systematic review of measurement properties of the EORTC QLQ-CR29
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van der Hout, Anja, Neijenhuijs, Koen I., Jansen, Femke, van Uden-Kraan, Cornelia F., Aaronson, Neil K., Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B., van de Poll-Franse, Lonneke V., Cuijpers, Pim, Verdonck-de Leeuw, Irma M., van der Hout, Anja, Neijenhuijs, Koen I., Jansen, Femke, van Uden-Kraan, Cornelia F., Aaronson, Neil K., Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B., van de Poll-Franse, Lonneke V., Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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Introduction: The EORTC QLQ-CR29 is a patient-reported outcome measure to evaluate health-related quality of life among colorectal cancer patients in research and clinical practice. The aim of this systematic review was to investigate whether the initial positive results regarding the measurement properties of the QLQ-CR29 are confirmed in subsequent studies. Methods: A systematic search of Embase, Medline, PsycINFO, and Web of Science was conducted to identify studies investigating the measurement properties of the QLQ-CR29 published up to January 2019. For the 11 included studies, data were extracted, methodological quality was assessed, results were synthesized, and evidence was graded according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on the measurement properties: structural validity, internal consistency, reliability, measurement error, construct validity (hypothesis testing, including known-group comparison, convergent and divergent validity), cross-cultural validity, and responsiveness. Results: Internal consistency was rated as “sufficient,” with low evidence. Reliability was rated as “insufficient,” with moderate evidence. Construct validity (hypothesis testing; known-group comparison, convergent and divergent validity) was rated as “inconsistent,” with moderate evidence. Structural validity, measurement error, and responsiveness were rated as “indeterminate” and could therefore not be graded. Conclusion: This review indicates that current evidence supporting the measurement properties of the QLQ-CR29 is limited. Additionally, better quality research is needed, taking into account the COSMIN methodology.
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- 2019
206. The Female Sexual Function Index (FSFI)-A Systematic Review of Measurement Properties
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Neijenhuijs, Koen, I, Hooghiemstra, Nienke, Holtmaat, Karen, Aaronson, Neil K., Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B., Cuijpers, Pim, Verdonck-de Leeuw, Irma M., Neijenhuijs, Koen, I, Hooghiemstra, Nienke, Holtmaat, Karen, Aaronson, Neil K., Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B., Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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- 2019
207. Dutch utility weights for the EORTC cancer-specific utility instrument: the Dutch EORTC QLU-C10D.
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Jansen, Femke, Verdonck-de Leeuw, Irma M., Gamper, Eva, Norman, Richard, Holzner, Bernhard, King, Madeleine, and Kemmler, Georg
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QUALITY of life , *APPETITE loss , *PHYSICAL mobility , *GENDER , *CANCER treatment , *APPETITE - Abstract
Purpose: To measure utilities among cancer patients, a cancer-specific utility instrument called the European Organization for Research and Treatment of Cancer (EORTC) QLU-C10D has been developed based on EORTC quality of life core module (QLQ-C30). This study aimed to provide Dutch utility weights for the QLU-C10D. Methods: A cross-sectional valuation study was performed in 1017 participants representative in age and gender of the Dutch general population. The valuation method was a discrete choice experiment containing 960 choice sets, i.e. pairs of QLU-C10D health states, each health state described in terms of the 10 QLU-C10D domains and the duration of that health state. Each participant considered 16 choice sets, choosing their preferred health state from each pair. Utility scores were derived using generalized estimation equation models. Non-monotonic levels were combined. Results: Utility decrements were generated for all 10 QLU-C10D domains, with largest decrements for pain (− 0.242), physical functioning (− 0.228), and role functioning (− 0.149). Non-monotonic levels of emotional functioning, pain, fatigue, sleep problems, and appetite loss were combined. No decrement in utility was seen in case of a little or quite a bit impairment in emotional functioning or a little pain. The mean QLU-C10D utility score of the participants was 0.85 (median = 0.91, interquartile range = 0.82 to 0.96). Conclusion: Dutch utility decrements were generated for the QLU-C10D. These are important for evaluating the cost-utility of new cancer treatments and supportive care interventions. Further insight is warranted into the added value of the QLU-C10D alongside other utility instruments. [ABSTRACT FROM AUTHOR]
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- 2021
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208. Effect and moderators of exercise on fatigue in patients with breast cancer: Meta-analysis of individual patient data
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van Vulpen, Jonna K., Sweegers, Maike G., Kalter, Joeri, Peeters, Petra H., Courneya, Kerry S., Newton, Robert U., Aaronson, Neil K., Jacobsen, Paul B., Steindorf, Karen, Stuiver, Martijn M., Hayes, Sandi, Mesters, Ilse, Knoop, Hans, Goedendorp, Martine, Mutrie, Nanette, Thorsen, Lene, Schmidt, Martina, Sonke, Gabe S., Bohus, Martin, James, Erica L., Oldenburg, Hester S., Velthuis, Miranda J., Nollet, Frans, Wenzel, Jennifer, Wiskemann, Joachim, Galvao, Daniel A., Chinapaw, Mai J., Irwin, Melinda L., Griffith, Kathleen A., van Weert, Ellen, Daley, Amanda J., McConnachie, Alex, Schulz, Karl-Heinz, Short, Camille E., Plotnikoff, Ron C., Potthoff, Karin, van Beurden, Marc, van Harten, Wim H., Schmitz, Kathryn H., Winters-Stone, Kerri M., Taaffe, Dennis R., van Mechelen, Willem, Kersten, Marie-Jose, Verdonck-de Leeuw, Irma M., Brug, Johannes, Buffart, Laurien M., May, Anne M., Epidemiology and Data Science, Rehabilitation medicine, Amsterdam Movement Sciences - Rehabilitation & Development, APH - Health Behaviors & Chronic Diseases, CCA - Cancer biology and immunology, CCA - Cancer immunology, CCA - Clinical Therapy Development, CCA - Evaluation of Cancer Care, CCA - Cancer Treatment and quality of life, Amsterdam Movement Sciences - Restoration and Development, Medical psychology, Public and occupational health, Otolaryngology / Head & Neck Surgery, APH - Mental Health, APH - Personalized Medicine, CCA - Imaging and biomarkers, CCA - Biomarkers, CCA - Quality of Life, Amsterdam Reproduction & Development (AR&D), APH - Societal Participation & Health, and APH - Methodology
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- 2018
209. Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data
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VAN VULPEN, JONNA K., primary, SWEEGERS, MAIKE G., additional, PEETERS, PETRA H. M., additional, COURNEYA, KERRY S., additional, NEWTON, ROBERT U., additional, AARONSON, NEIL K., additional, JACOBSEN, PAUL B., additional, GALVÃO, DANIEL A., additional, CHINAPAW, MAI J., additional, STEINDORF, KAREN, additional, IRWIN, MELINDA L., additional, STUIVER, MARTIJN M., additional, HAYES, SANDI, additional, GRIFFITH, KATHLEEN A., additional, MESTERS, ILSE, additional, KNOOP, HANS, additional, GOEDENDORP, MARTINE M., additional, MUTRIE, NANETTE, additional, DALEY, AMANDA J., additional, MCCONNACHIE, ALEX, additional, BOHUS, MARTIN, additional, THORSEN, LENE, additional, SCHULZ, KARL-HEINZ, additional, SHORT, CAMILLE E., additional, JAMES, ERICA L., additional, PLOTNIKOFF, RONALD C., additional, SCHMIDT, MARTINA E., additional, ULRICH, CORNELIA M., additional, VAN BEURDEN, MARC, additional, OLDENBURG, HESTER S., additional, SONKE, GABE S., additional, VAN HARTEN, WIM H., additional, SCHMITZ, KATHRYN H., additional, WINTERS-STONE, KERRI M., additional, VELTHUIS, MIRANDA J., additional, TAAFFE, DENNIS R., additional, VAN MECHELEN, WILLEM, additional, KERSTEN, MARIE JOSÉ, additional, NOLLET, FRANS, additional, WENZEL, JENNIFER, additional, WISKEMANN, JOACHIM, additional, VERDONCK-DE LEEUW, IRMA M., additional, BRUG, JOHANNES, additional, MAY, ANNE M., additional, and BUFFART, LAURIEN M., additional
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- 2019
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210. Translation of the eHealth Impact Questionnaire for a Population of Dutch Electronic Health Users: Validation Study
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Neijenhuijs, Koen Ilja, primary, van der Hout, Anja, additional, Veldhuijzen, Evalien, additional, Scholten-Peeters, Gwendolijne G M, additional, van Uden-Kraan, Cornelia F, additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M, additional
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- 2019
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211. Introducing Decision Aids into Routine Prostate Cancer Care in The Netherlands: Implementation and Patient Evaluations from the Multi-regional JIPPA Initiative
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Cuypers, Maarten, primary, Al-Itejawi, Hoda H. M., additional, van Uden-Kraan, Cornelia F., additional, Stalmeier, Peep F. M., additional, Lamers, Romy E. D., additional, van Oort, Inge M., additional, Somford, Diederik M., additional, van Moorselaar, Reindert Jeroen A., additional, Verdonck-de Leeuw, Irma M., additional, van de Poll-Franse, Lonneke V., additional, van Tol-Geerdink, Julia J., additional, and de Vries, Marieke, additional
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- 2019
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212. Factors associated with depression over time in head and neck cancer patients: A systematic review
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Korsten, Laura H.A., primary, Jansen, Femke, additional, Haan, Ben J.F., additional, Sent, Danielle, additional, Cuijpers, Pim, additional, Leemans, C. René, additional, and Verdonck‐de Leeuw, Irma M., additional
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- 2019
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213. Ecological momentary assessments among patients with cancer: A scoping review
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Kampshoff, Caroline S., primary, Verdonck‐de Leeuw, Irma M., additional, Oijen, Martijn G., additional, Sprangers, Mirjam A., additional, and Buffart, Laurien M., additional
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- 2019
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214. Health-related and cancer-related Internet use by patients treated with total laryngectomy
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van Uden-Kraan, Cornelia F., primary, Jansen, Femke, additional, Lissenberg-Witte, Birgit I., additional, Eerenstein, Simone E. J., additional, Leemans, C. René, additional, and Verdonck-de Leeuw, Irma M., additional
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- 2019
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215. Stepped care targeting psychological distress in head and neck cancer and lung cancer patients: which groups specifically benefit? Secondary analyses of a randomized controlled trial
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Jansen, Femke, primary, Lissenberg-Witte, Birgit I., additional, Krebber, Anna M. H., additional, Cuijpers, Pim, additional, de Bree, Remco, additional, Becker-Commissaris, Annemarie, additional, Smit, Egbert F., additional, van Straten, Annemieke, additional, Eeckhout, Guus M., additional, Beekman, Aartjan T. F., additional, Leemans, C. René, additional, and Verdonck-de Leeuw, Irma M., additional
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- 2019
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216. Assessment of Neurocognitive Impairment and Speech Functioning Before Head and Neck Cancer Treatment
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Piai, Vitória, primary, Prins, Judith B., additional, Verdonck-de Leeuw, Irma M., additional, Leemans, C. René, additional, Terhaard, Chris H. J., additional, Langendijk, Johannes A., additional, Baatenburg de Jong, Robert J., additional, Smit, Johannes H., additional, Takes, Robert P., additional, and Kessels, Roy P. C., additional
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- 2019
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217. Translation of the eHealth Impact Questionnaire for a Population of Dutch Electronic Health Users: Validation Study (Preprint)
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Neijenhuijs, Koen Ilja, primary, van der Hout, Anja, additional, Veldhuijzen, Evalien, additional, Scholten-Peeters, Gwendolijne G M, additional, van Uden-Kraan, Cornelia F, additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M, additional
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- 2019
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218. eHealth Impact Questionnaire--Dutch Version
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Neijenhuijs, Koen Ilja, primary, van der Hout, Anja, additional, Veldhuijzen, Evalien, additional, Scholten-Peeters, Gwendolijne G. M., additional, van Uden-Kraan, Cornelia F., additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M., additional
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- 2019
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219. Adoption and implementation of a web-based self-management application “Oncokompas” in routine cancer care: a national pilot study
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Matthijs de Wit, L., primary, van Uden-Kraan, Cornelia F., additional, Lissenberg-Witte, Birgit I., additional, Melissant, Heleen C., additional, Fleuren, Margot A.H., additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M., additional
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- 2018
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220. Development and Psychometric Evaluation of an Item Bank for Computerized Adaptive Testing of the EORTC Insomnia Dimension in Cancer Patients (EORTC CAT-SL).
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Dirven, Linda, Petersen, Morten Aa., Aaronson, Neil K., Chie, Wei-Chu, Conroy, Thierry, Costantini, Anna, Hammerlid, Eva, Velikova, Galina, Verdonck-de Leeuw, Irma M., Young, Teresa, and Groenvold, Mogens
- Abstract
To further advance assessment of patient-reported outcomes, the European Organisation of Research and Treatment of Cancer (EORTC) Quality of Life Group has developed computerized adaptive test (CAT) versions of all EORTC Quality of Life Core Questionnaire (QLQ-C30) scales/items. The aim of this study was to develop and evaluate an item bank for CAT measurement of insomnia (CAT-SL). In line with the EORTC guidelines, the developmental process comprised four phases: (I) defining the concept insomnia and literature search, (II) selection and formulation of new items, (III) pre-testing and (IV) field-testing, including psychometric analyses of the final item bank. In phase I, the literature search identified 155 items that were compatible with our conceptualisation of insomnia, including both quantity and quality of sleep. In phase II, following a multistep-approach, this number was reduced to 15 candidate items. Pre-testing of these items in cancer patients (phase III) resulted in an item list of 14 items, which were field-tested among 1094 patients in phase IV. Psychometric evaluations showed that eight items could be retained in a unidimensional model. The final item bank yielded greater measurement precision than the original QLQ-C30 insomnia item. It was estimated that administering two or more items from the insomnia item bank with CAT results in a saving in sample size between approximately 15–25%. The 8-item EORTC CAT-SL item bank facilitates precise and efficient measurement of insomnia as part of the EORTC CAT system of health-related quality life assessment in both clinical research and practice. [ABSTRACT FROM AUTHOR]
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- 2021
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221. A randomized controlled trial on the efficacy of life review therapy targeting incurably ill cancer patients: do their informal caregivers benefit?
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Kleijn, Gitta, Lissenberg-Witte, Birgit I., Bohlmeijer, Ernst T., Willemsen, Vincent, Becker-Commissaris, Annemarie, Eeltink, Corien M., Bruynzeel, Anna M.E., van der Vorst, Maurice J., Cuijpers, Pim, and Verdonck-de Leeuw, Irma M.
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CAREGIVERS ,BURDEN of care ,RANDOMIZED controlled trials ,SERVICES for caregivers ,POSTTRAUMATIC growth ,CANCER patients - Abstract
Purpose: Investigate whether Life Review Therapy and Memory Specificity Training (LRT-MST) targeting incurably ill cancer patients may also have a beneficial effect on caregiving burden, symptoms of anxiety and depression, and posttraumatic growth of the informal caregivers. Methods: Data was collected in the context of a randomized controlled trial (RCT) (secondary analyses) on the effect of LRT-MST among incurably cancer patients. Informal caregivers of participating patients were asked to complete outcome measures at baseline (T0), post-intervention (T1), and 1-month follow-up (T2): caregiver burden (caregivers reaction assessment scale (CRA)), symptoms of anxiety and depression (hospital anxiety and depression scale), and posttraumatic growth (posttraumatic growth inventory). Linear mixed models (intention to treat) were used to assess group differences in changes over time. Effect size and independent samples t tests were used to assess group differences at T1 and T2. Results: In total, 64 caregivers participated. At baseline, 56% of the caregivers experienced anxiety and 30% depression. No significant effect was found on these symptoms nor on posttraumatic growth or most aspects of caregiver burden. There was a significant effect of LRT-MST on the course of self-esteem (subscale CRA) (p = 0.013). Effect size was moderate post-intervention (ES = − 0.38, p = 0.23) and at 3-month follow-up (ES = 0.53, p = 0.083). Conclusions: Many caregivers of incurably ill cancer patients experience symptoms of anxiety and depression. LRT-MST does not improve symptoms of depression and anxiety, negative aspects of caregiver burden, or posttraumatic growth. LRT-MST may have a protective effect on self-esteem of informal caregivers (positive aspect of caregiver burden). Trial registration number: Netherlands Trial Register (NTR 2256), registered on 23-3-2010. [ABSTRACT FROM AUTHOR]
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- 2021
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222. Poor sleep quality among newly diagnosed head and neck cancer patients: prevalence and associated factors.
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Santoso, Angelina M. M., Jansen, Femke, Lissenberg-Witte, Birgit I., Baatenburg de Jong, Robert J., Langendijk, Johannes A., Leemans, C. René, Smit, Johannes H., Takes, Robert P., Terhaard, Chris H. J., van Straten, Annemieke, Verdonck-de Leeuw, Irma M., and NET-QUBIC consortium
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CANCER patients ,HEAD & neck cancer ,SLEEP ,PSYCHOLOGICAL adaptation ,SOCIODEMOGRAPHIC factors ,ODDS ratio ,HEAD tumors ,RESEARCH ,CROSS-sectional method ,RESEARCH methodology ,EVALUATION research ,MEDICAL cooperation ,COMPARATIVE studies ,DISEASE prevalence ,NECK tumors ,LONGITUDINAL method ,DISEASE complications - Abstract
Background: Head and neck cancer (HNC) patients often suffer from distress attributed to their cancer diagnosis which may disturb their sleep. However, there is lack of research about poor sleep quality among newly diagnosed HNC patients. Therefore, our aim was to investigate the prevalence and the associated factors of poor sleep quality among HNC patients before starting treatment.Materials and Methods: A cross-sectional study was conducted using the baseline data from NET-QUBIC study, an ongoing multi-center cohort of HNC patients in the Netherlands. Poor sleep quality was defined as a Pittsburgh Sleep Quality Index (PSQI) total score of > 5. Risk factors examined were sociodemographic factors (age, sex, education level, living situation), clinical characteristics (HNC subsite, tumor stage, comorbidity, performance status), lifestyle factors, coping styles, and HNC symptoms.Results: Among 560 HNC patients, 246 (44%) had poor sleep quality before start of treatment. Several factors were found to be significantly associated with poor sleep: younger age (odds ratio [OR] for each additional year 0.98, 95% CI 0.96-1.00), being female (OR 2.6, 95% CI 1.7-4.1), higher passive coping style (OR 1.18, 95% CI 1.09-1.28), more oral pain (OR 1.10, 95% CI 1.01-1.19), and less sexual interest and enjoyment (OR 1.13, 95% CI 1.06-1.20).Conclusion: Poor sleep quality is highly prevalent among HNC patients before start of treatment. Early evaluation and tailored intervention to improve sleep quality are necessary to prepare these patients for HNC treatment and its consequences. [ABSTRACT FROM AUTHOR]- Published
- 2021
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223. A systematic review of the measurement properties of the Body Image Scale (BIS) in cancer patients
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Melissant, Heleen C, Neijenhuijs, Koen I, Jansen, Femke, Aaronson, Neil K, Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B, van Uden-Kraan, Cornelia F, Cuijpers, Pim, Verdonck-de Leeuw, Irma M, Melissant, Heleen C, Neijenhuijs, Koen I, Jansen, Femke, Aaronson, Neil K, Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B, van Uden-Kraan, Cornelia F, Cuijpers, Pim, and Verdonck-de Leeuw, Irma M
- Abstract
INTRODUCTION: Body image is acknowledged as an important aspect of health-related quality of life in cancer patients. The Body Image Scale (BIS) is a patient-reported outcome measure (PROM) to evaluate body image in cancer patients. The aim of this study was to systematically review measurement properties of the BIS among cancer patients.METHODS: A search in Embase, MEDLINE, PsycINFO, and Web of Science was performed to identify studies that investigated measurement properties of the BIS (Prospero ID 42017057237). Study quality was assessed (excellent, good, fair, poor), and data were extracted and analyzed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on structural validity, internal consistency, reliability, measurement error, hypothesis testing for construct validity, and responsiveness. Evidence was categorized into sufficient, insufficient, inconsistent, or indeterminate.RESULTS: Nine studies were included. Evidence was sufficient for structural validity (one factor solution), internal consistency (α = 0.86-0.96), and reliability (r > 0.70); indeterminate for measurement error (information on minimal important change lacked) and responsiveness (increasing body image disturbance in only one study); and inconsistent for hypothesis testing (conflicting results). Quality of the evidence was moderate to low. No studies reported on cross-cultural validity.CONCLUSION: The BIS is a PROM with good structural validity, internal consistency, and test-retest reliability, but good quality studies on the other measurement properties are needed to optimize evidence. It is recommended to include a wider variety of cancer diagnoses and treatment modalities in these future studies.
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- 2018
224. Targeting exercise interventions to patients with cancer in need: An individual patient data meta-analysis
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Buffart, Laurien M., Sweegers, Maike G., May, Anne M., Chinapaw, Mai J., van Vulpen, Jonna K., Newton, Robert U., Galvao, Daniel A., Aaronson, Neil K., Stuiver, Martjin M., Jacobsen, Paul B., Verdonck-de Leeuw, Irma M., Steindorf, Karen, Irwin, Melinda L., Hayes, Sandi, Griffith, Kathleen A., Lucia, Alejandro, Herrero-Roman, Fernando, Mesters, Ilse, van Weert, Ellen, Knoop, Hans, Goedendorp, Martine M., Mutrie, Nanette, Daley, Amanda J., McConnachie, Alex, Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Short, Camille E., James, Erica L., Plotnikoff, Ronald C., Arbane, Gill, Schmidt, Martina E., Potthoff, Karin, van Beurden, Marc, Oldenburg, Hester S., Sonke, Gabe S., van Harten, Wim H., Garrod, Rachel, Schmitz, Kathryn H., Winters-Stone, Kerri M., Velthuis, Miranda J., Taaffe, Dennis R., van Mechelen, Willem, Jose Kersten, Marie, Nollet, Frans, Wenzel, Jennifer, Wiskemann, Joachim, Brug, Johannes, Courneya, Kerry S., Buffart, Laurien M., Sweegers, Maike G., May, Anne M., Chinapaw, Mai J., van Vulpen, Jonna K., Newton, Robert U., Galvao, Daniel A., Aaronson, Neil K., Stuiver, Martjin M., Jacobsen, Paul B., Verdonck-de Leeuw, Irma M., Steindorf, Karen, Irwin, Melinda L., Hayes, Sandi, Griffith, Kathleen A., Lucia, Alejandro, Herrero-Roman, Fernando, Mesters, Ilse, van Weert, Ellen, Knoop, Hans, Goedendorp, Martine M., Mutrie, Nanette, Daley, Amanda J., McConnachie, Alex, Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Short, Camille E., James, Erica L., Plotnikoff, Ronald C., Arbane, Gill, Schmidt, Martina E., Potthoff, Karin, van Beurden, Marc, Oldenburg, Hester S., Sonke, Gabe S., van Harten, Wim H., Garrod, Rachel, Schmitz, Kathryn H., Winters-Stone, Kerri M., Velthuis, Miranda J., Taaffe, Dennis R., van Mechelen, Willem, Jose Kersten, Marie, Nollet, Frans, Wenzel, Jennifer, Wiskemann, Joachim, Brug, Johannes, and Courneya, Kerry S.
- Abstract
Background Exercise effects in cancer patients often appear modest, possibly because interventions rarely target patients most in need. This study investigated the moderator effects of baseline values on the exercise outcomes of fatigue, aerobic fitness, muscle strength, quality of life (QoL), and self-reported physical function (PF) in cancer patients during and post-treatment. Methods Individual patient data from 34 randomized exercise trials (n = 4519) were pooled. Linear mixed-effect models were used to study moderator effects of baseline values on exercise intervention outcomes and to determine whether these moderator effects differed by intervention timing (during vs post-treatment). All statistical tests were two-sided. Results Moderator effects of baseline fatigue and PF were consistent across intervention timing, with greater effects in patients with worse fatigue (Pinteraction = .05) and worse PF (Pinteraction = .003). Moderator effects of baseline aerobic fitness, muscle strength, and QoL differed by intervention timing. During treatment, effects on aerobic fitness were greater for patients with better baseline aerobic fitness (Pinteraction = .002). Post-treatment, effects on upper (Pinteraction < .001) and lower (Pinteraction = .01) body muscle strength and QoL (Pinteraction < .001) were greater in patients with worse baseline values. Conclusion Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific subgroups may be especially beneficial and cost effective. For fatigue and PF, interventions during and post-treatment should target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment.
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- 2018
225. Cost-utility analysis of meaning-centered group psychotherapy for cancer survivors
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van der Spek, Nadia, Jansen, Femke, Holtmaat, Karen, Vos, Joël, Breitbart, William, van Uden-Kraan, Cornelia F., Tollenaar, Rob A.E.M., Cuijpers, Pim, Coupé, Veerle M.H., Verdonck-de Leeuw, Irma M., van der Spek, Nadia, Jansen, Femke, Holtmaat, Karen, Vos, Joël, Breitbart, William, van Uden-Kraan, Cornelia F., Tollenaar, Rob A.E.M., Cuijpers, Pim, Coupé, Veerle M.H., and Verdonck-de Leeuw, Irma M.
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Background: Meaning-centered group psychotherapy for cancer survivors (MCGP-CS) improves meaning, psychological well-being, and mental adjustment to cancer and reduces psychological distress. This randomized controlled trial was conducted to investigate the cost-utility of MCGP-CS compared with supportive group psychotherapy (SGP) and care-as-usual (CAU). Methods: In total, 170 patients were randomized to MCGP-CS, SGP, or CAU. Intervention costs, direct medical and nonmedical costs, productivity losses, and health-related quality of life were measured until 6 months follow-up, using the TIC-P, PRODISQ, data from the hospital information system, and the EQ-5D. The cost-utility was calculated by comparing mean cumulative costs and quality-adjusted life years (QALYs). Results: Mean total costs ranged from €4492 (MCGP-CS) to €5304 (CAU). Mean QALYs ranged.507 (CAU) to.540 (MCGP-CS). MCGP-CS had a probability of 74% to be both less costly and more effective than CAU, and 49% compared with SGP. Sensitivity analyses showed these findings are robust. If society is willing to pay €0 for one gained QALY, MCGP-CS has a 78% probability of being cost-effective compared with CAU. This increases to 85% and 92% at willingness-to-pay thresholds of €10 000 and €30 000, which are commonly accepted thresholds. Conclusions: MCGP-CS is highly likely a cost-effective intervention, meaning that there is a positive balance between the costs and gains of MCGP-CS, in comparison with SGP and CAU.
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- 2018
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226. The efficacy of Life Review Therapy combined with Memory Specificity Training (LRT-MST) targeting cancer patients in palliative care : A randomized controlled trial
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Kleijn, Gitta, Lissenberg-Witte, Birgit I, Bohlmeijer, Ernst T, Steunenberg, Bas, Knipscheer-Kuijpers, Kitty, Willemsen, Vincent, Becker, Annemarie, Smit, Egbert F, Eeltink, Corien M, Bruynzeel, Anna M E, van der Vorst, Maurice, de Bree, Remco, Leemans, C René, van den Brekel, Michiel W M, Cuijpers, Pim, Verdonck-de Leeuw, Irma M, Kleijn, Gitta, Lissenberg-Witte, Birgit I, Bohlmeijer, Ernst T, Steunenberg, Bas, Knipscheer-Kuijpers, Kitty, Willemsen, Vincent, Becker, Annemarie, Smit, Egbert F, Eeltink, Corien M, Bruynzeel, Anna M E, van der Vorst, Maurice, de Bree, Remco, Leemans, C René, van den Brekel, Michiel W M, Cuijpers, Pim, and Verdonck-de Leeuw, Irma M
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- 2018
227. Targeting Exercise Interventions to Patients With Cancer in Need : An Individual Patient Data Meta-Analysis
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Buffart, Laurien M, Sweegers, Maike G, May, Anne M, Chinapaw, Mai J, van Vulpen, Jonna K, Newton, Rob U, Galvão, Daniel A, Aaronson, Neil K, Stuiver, Martijn M, Jacobsen, Paul B, Verdonck-de Leeuw, Irma M, Steindorf, Karen, Irwin, Melinda L, Hayes, Sandi, Griffith, Kathleen A, Lucia, Alejandro, Herrero-Roman, Fernando, Mesters, Ilse, van Weert, Ellen, Knoop, Hans, Goedendorp, Martine M, Mutrie, Nanette, Daley, Amanda J, McConnachie, Alex, Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Short, Camille E, James, Erica L, Plotnikoff, Ronald C, Arbane, Gill, Schmidt, Martina E, Potthoff, Karin, van Beurden, Marc, Oldenburg, Hester S, Sonke, Gabe S, van Harten, Wim H, Garrod, Rachel, Schmitz, Kathryn H, Winters-Stone, Kerri M, Velthuis, Miranda J, Taaffe, Dennis R, van Mechelen, Willem, José Kersten, Marie, Nollet, Frans, Wenzel, Jennifer, Wiskemann, Joachim, Brug, Johannes, Courneya, Kerry S, Buffart, Laurien M, Sweegers, Maike G, May, Anne M, Chinapaw, Mai J, van Vulpen, Jonna K, Newton, Rob U, Galvão, Daniel A, Aaronson, Neil K, Stuiver, Martijn M, Jacobsen, Paul B, Verdonck-de Leeuw, Irma M, Steindorf, Karen, Irwin, Melinda L, Hayes, Sandi, Griffith, Kathleen A, Lucia, Alejandro, Herrero-Roman, Fernando, Mesters, Ilse, van Weert, Ellen, Knoop, Hans, Goedendorp, Martine M, Mutrie, Nanette, Daley, Amanda J, McConnachie, Alex, Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Short, Camille E, James, Erica L, Plotnikoff, Ronald C, Arbane, Gill, Schmidt, Martina E, Potthoff, Karin, van Beurden, Marc, Oldenburg, Hester S, Sonke, Gabe S, van Harten, Wim H, Garrod, Rachel, Schmitz, Kathryn H, Winters-Stone, Kerri M, Velthuis, Miranda J, Taaffe, Dennis R, van Mechelen, Willem, José Kersten, Marie, Nollet, Frans, Wenzel, Jennifer, Wiskemann, Joachim, Brug, Johannes, and Courneya, Kerry S
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- 2018
228. Understanding the quality of life (QOL) issues in survivors of cancer: towards the development of an EORTC QOL cancer survivorship questionnaire
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van Leeuwen, Marieke, Husson, Olga, Alberti, Paola, Arraras, Juan Ignacio, Chinot, Olivier L, Costantini, Anna, Darlington, Anne-Sophie, Dirven, Linda, Eichler, Martin, Hammerlid, Eva B, Holzner, Bernhard, Johnson, Colin D, Kontogianni, Meropi, Kjær, Trille Kristina, Morag, Ofir, Nolte, Sandra, Nordin, Andrew, Pace, Andrea, Pinto, Monica, Polz, Katja, Ramage, John, Reijneveld, Jaap C, Serpentini, Samantha, Tomaszewski, Krzysztof A, Vassiliou, Vassilios, Verdonck-de Leeuw, Irma M, Vistad, Ingvild, Young, Teresa E, Aaronson, Neil K, van de Poll-Franse, Lonneke V, EORTC QLG, van Leeuwen, Marieke, Husson, Olga, Alberti, Paola, Arraras, Juan Ignacio, Chinot, Olivier L, Costantini, Anna, Darlington, Anne-Sophie, Dirven, Linda, Eichler, Martin, Hammerlid, Eva B, Holzner, Bernhard, Johnson, Colin D, Kontogianni, Meropi, Kjær, Trille Kristina, Morag, Ofir, Nolte, Sandra, Nordin, Andrew, Pace, Andrea, Pinto, Monica, Polz, Katja, Ramage, John, Reijneveld, Jaap C, Serpentini, Samantha, Tomaszewski, Krzysztof A, Vassiliou, Vassilios, Verdonck-de Leeuw, Irma M, Vistad, Ingvild, Young, Teresa E, Aaronson, Neil K, van de Poll-Franse, Lonneke V, and EORTC QLG
- Abstract
BACKROUND: The number of cancer survivors is growing steadily and increasingly, clinical trials are being designed to include long-term follow-up to assess not only survival, but also late effects and health-related quality of life (HRQOL). Therefore it is is essential to develop patient-reported outcome measures (PROMs) that capture the full range of issues relevant to disease-free cancer survivors. The objectives of this project are: 1) to develop a European Organisation for Research and Treatment of Cancer (EORTC) questionnaire that captures the full range of physical, mental and social HRQOL issues relevant to disease-free cancer survivors; and 2) to determine at which minimal time since completion of treatment the questionnaire should be used. METHODS: We reviewed 134 publications on cancer survivorship and interviewed 117 disease-free cancer survivors with 11 different types of cancer across 14 countries in Europe to generate an exhaustive, provisional list of HRQOL issues relevant to cancer survivors. The resulting issue list, the EORTC core questionnaire (QLQ-C30), and site-specific questionnaire modules were completed by a second group of 458 survivors. RESULTS: We identified 116 generic survivorship issues. These issues covered body image, cognitive functioning, health behaviors, negative and positive outlook, health distress, mental health, fatigue, sleep problems, physical functioning, pain, several physical symptoms, social functioning, and sexual problems. Patients rated most of the acute symptoms of cancer and its treatment (e.g. nausea) as no longer relevant approximately one year after completion of treatment. CONCLUSIONS: Compared to existing cancer survivorship questionnaires, our findings underscore the relevance of assessing issues related to chronic physical side effects of treatment such as neuropathy and joint pain. We will further develop a core survivorship questionnaire and three site-specific modules for disease-free adult cancer sur
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- 2018
229. A systematic review of the measurement properties of the European Organisation for Research and Treatment of Cancer In-patient Satisfaction with Care Questionnaire, the EORTC IN-PATSAT32
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Neijenhuijs, Koen I, Jansen, Femke, Aaronson, Neil K, Brédart, Anne, Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B, Cuijpers, Pim, Verdonck-de Leeuw, Irma M, Neijenhuijs, Koen I, Jansen, Femke, Aaronson, Neil K, Brédart, Anne, Grønvold, Mogens, Holzner, Bernhard, Terwee, Caroline B, Cuijpers, Pim, and Verdonck-de Leeuw, Irma M
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PURPOSE: The EORTC IN-PATSAT32 is a patient-reported outcome measure (PROM) to assess cancer patients' satisfaction with in-patient health care. The aim of this study was to investigate whether the initial good measurement properties of the IN-PATSAT32 are confirmed in new studies.METHODS: Within the scope of a larger systematic review study (Prospero ID 42017057237), a systematic search was performed of Embase, Medline, PsycINFO, and Web of Science for studies that investigated measurement properties of the IN-PATSAT32 up to July 2017. Study quality was assessed, data were extracted, and synthesized according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology.RESULTS: Nine studies were included in this review. The evidence on reliability and construct validity were rated as sufficient and of the quality of the evidence as moderate. The evidence on structural validity was rated as insufficient and of low quality. The evidence on internal consistency was indeterminate. Measurement error, responsiveness, criterion validity, and cross-cultural validity were not reported in the included studies. Measurement error could be calculated for two studies and was judged indeterminate.CONCLUSION: In summary, the IN-PATSAT32 performs as expected with respect to reliability and construct validity. No firm conclusions can be made yet whether the IN-PATSAT32 also performs as well with respect to structural validity and internal consistency. Further research on these measurement properties of the PROM is therefore needed as well as on measurement error, responsiveness, criterion validity, and cross-cultural validity. For future studies, it is recommended to take the COSMIN methodology into account.
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- 2018
230. Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis
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Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Buffart, Laurien M, Sweegers, Maike G, May, Anne M, Chinapaw, Mai J, van Vulpen, Jonna K, Newton, Rob U, Galvão, Daniel A, Aaronson, Neil K, Stuiver, Martijn M, Jacobsen, Paul B, Verdonck-de Leeuw, Irma M, Steindorf, Karen, Irwin, Melinda L, Hayes, Sandi, Griffith, Kathleen A, Lucia, Alejandro, Herrero-Roman, Fernando, Mesters, Ilse, van Weert, Ellen, Knoop, Hans, Goedendorp, Martine M, Mutrie, Nanette, Daley, Amanda J, McConnachie, Alex, Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Short, Camille E, James, Erica L, Plotnikoff, Ronald C, Arbane, Gill, Schmidt, Martina E, Potthoff, Karin, van Beurden, Marc, Oldenburg, Hester S, Sonke, Gabe S, van Harten, Wim H, Garrod, Rachel, Schmitz, Kathryn H, Winters-Stone, Kerri M, Velthuis, Miranda J, Taaffe, Dennis R, van Mechelen, Willem, José Kersten, Marie, Nollet, Frans, Wenzel, Jennifer, Wiskemann, Joachim, Brug, Johannes, Courneya, Kerry S, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Buffart, Laurien M, Sweegers, Maike G, May, Anne M, Chinapaw, Mai J, van Vulpen, Jonna K, Newton, Rob U, Galvão, Daniel A, Aaronson, Neil K, Stuiver, Martijn M, Jacobsen, Paul B, Verdonck-de Leeuw, Irma M, Steindorf, Karen, Irwin, Melinda L, Hayes, Sandi, Griffith, Kathleen A, Lucia, Alejandro, Herrero-Roman, Fernando, Mesters, Ilse, van Weert, Ellen, Knoop, Hans, Goedendorp, Martine M, Mutrie, Nanette, Daley, Amanda J, McConnachie, Alex, Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Short, Camille E, James, Erica L, Plotnikoff, Ronald C, Arbane, Gill, Schmidt, Martina E, Potthoff, Karin, van Beurden, Marc, Oldenburg, Hester S, Sonke, Gabe S, van Harten, Wim H, Garrod, Rachel, Schmitz, Kathryn H, Winters-Stone, Kerri M, Velthuis, Miranda J, Taaffe, Dennis R, van Mechelen, Willem, José Kersten, Marie, Nollet, Frans, Wenzel, Jennifer, Wiskemann, Joachim, Brug, Johannes, and Courneya, Kerry S
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- 2018
231. The efficacy of Life Review Therapy combined with Memory Specificity Training (LRT-MST) targeting cancer patients in palliative care: A randomized controlled trial
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NUZO, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Kleijn, Gitta, Lissenberg-Witte, Birgit I, Bohlmeijer, Ernst T, Steunenberg, Bas, Knipscheer-Kuijpers, Kitty, Willemsen, Vincent, Becker, Annemarie, Smit, Egbert F, Eeltink, Corien M, Bruynzeel, Anna M E, van der Vorst, Maurice, de Bree, Remco, Leemans, C René, van den Brekel, Michiel W M, Cuijpers, Pim, Verdonck-de Leeuw, Irma M, NUZO, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Kleijn, Gitta, Lissenberg-Witte, Birgit I, Bohlmeijer, Ernst T, Steunenberg, Bas, Knipscheer-Kuijpers, Kitty, Willemsen, Vincent, Becker, Annemarie, Smit, Egbert F, Eeltink, Corien M, Bruynzeel, Anna M E, van der Vorst, Maurice, de Bree, Remco, Leemans, C René, van den Brekel, Michiel W M, Cuijpers, Pim, and Verdonck-de Leeuw, Irma M
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- 2018
232. Health-care professionals' perspective on discussing sexual issues in adult patients after haematopoietic cell transplantation article
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Eeltink, Corien M., Witte, Birgit I., Stringer, Jacqui, Liptrott, Sarah, Babic, Aleksandra, Greenfield, Diana M., Salooja, Nina, Incrocci, Luca, Visser, Otto, Verdonck-De Leeuw, Irma M., Duarte, Rafael F., Zweegman, Sonja, Eeltink, Corien M., Witte, Birgit I., Stringer, Jacqui, Liptrott, Sarah, Babic, Aleksandra, Greenfield, Diana M., Salooja, Nina, Incrocci, Luca, Visser, Otto, Verdonck-De Leeuw, Irma M., Duarte, Rafael F., and Zweegman, Sonja
- Abstract
The majority of adult patients have sexual concerns after post-haematopoietic cell transplantation. Even so, health-care professionals (HCP) do not routinely discuss these problems. We, therefore, surveyed all the members of the European Society for Blood and Marrow Transplantation to evaluate the barriers and facilitators to discussing sexual issues. The 73-item web-survey was completed by 166 registered nurses (RNs) and 126 medical doctors (MDs). Sixty-eight percent reported that they seldom discussed sexual issues. Younger MDs (p < 0.001) and those who work in non-western European countries (p = 0.003), RNs with probably less sexual education themselves (p = 0.002), MDs and RNs who have limited knowledge about sexual complications (p < 0.001) and MDs and RNs who feel uncomfortable discussing sexual issues (p < 0.001) are all less likely to discuss these matters. The major perceived barriers were that patients might be embarrassed if sexual issues were discussed in the presence of a relative (60% RNs, 67% MDs) and that professionals prefer patients to raise sexual issues themselves (54% RNs, 44% MDs). The most important perceived facilitator was for the patient to initiate discussion (≥ 90% for RNs and MDs). Overall, haematopoietic cell transplantation survivors may not be receiving the support on sexual issues they probably need.
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- 2018
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233. Which exercise prescriptions improve quality of life and physical function in patients with cancer during and following treatment? A systematic review and meta-analysis of randomised controlled trials
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Sweegers, Maike G., Altenburg, Teatske M., Chinapaw, Mai J., Kalter, Joeri, Verdonck-De Leeuw, Irma M., Courneya, Kerry S., Newton, Robert U., Aaronson, Neil K., Jacobsen, Paul B., Brug, Johannes, Buffart, Laurien M., Sweegers, Maike G., Altenburg, Teatske M., Chinapaw, Mai J., Kalter, Joeri, Verdonck-De Leeuw, Irma M., Courneya, Kerry S., Newton, Robert U., Aaronson, Neil K., Jacobsen, Paul B., Brug, Johannes, and Buffart, Laurien M.
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Objective Certain exercise prescriptions for patients with cancer may improve self-reported quality of life (QoL) and self-reported physical function (PF). We investigated the effects of exercise on QoL and PF in patients with cancer and studied differences in effects between different intervention-related and exercise-related characteristics. Design We searched four electronic databases to identify randomised controlled trials investigating exercise effects on QoL and PF in patients with cancer. Pooled effects (Hedges' g) were calculated using Comprehensive Meta-Analysis software. Subgroup analyses were conducted based on intervention dimensions, including timing, duration and delivery mode, and exercise dimensions, including frequency, intensity, type and time (FITT factors). Results We included 74 exercise arms. Patients who were randomised to exercise interventions had significantly improved QoL (g=0.15, 95% CI (0.10 to 0.20), n=67 exercise arms) and PF (g=0.21, 95% CI (0.15 to 0.27), n=59 exercise arms) compared with patients in control groups. We found a significant between-group difference for exercise delivery mode, with significant beneficial effects for supervised exercise interventions (g=0.20, 95% CI (0.14 to 0.26) for QoL and g=0.27, 95% CI (0.20 to 0.33) for PF), but not for unsupervised interventions (g=0.04, 95% CI (-0.06 to 0.13) for QoL and g=0.09, 95% CI (-0.01 to 0.19) for PF). No statistically significant differences in intervention effects were found for variations in intervention timing, duration or exercise FITT factors. Unsupervised exercise with higher weekly energy expenditure was more effective than unsupervised exercise with lower energy expenditure (z=2.34, p=0.02). Conclusions Exercise interventions, especially when supervised, have statistically significant and small clinical benefit on self-reported QoL and PF in patients with cancer. Unsupervised exercise intervention effects on PF were larger when prescribed at a higher weekly e
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- 2018
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234. The EORTC CAT Core-The computer adaptive version of the EORTC QLQ-C30 questionnaire
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Petersen, Morten Aa, Aaronson, Neil K, Arraras, Juan I, Chie, Wei-Chu, Conroy, Thierry, Costantini, Anna, Dirven, Linda, Fayers, Peter, Gamper, Eva-Maria, Giesinger, Johannes M, Habets, Esther J J, Hammerlid, Eva, Helbostad, Jorunn, Hjermstad, Marianne J, Holzner, Bernhard, Johnson, Colin, Kemmler, Georg, King, Madeleine T, Kaasa, Stein, Loge, Jon H, Reijneveld, Jaap C, Singer, Susanne, Taphoorn, Martin J B, Thamsborg, Lise H, Tomaszewski, Krzysztof A, Velikova, Galina, Verdonck-de Leeuw, Irma M, Young, Teresa, Groenvold, Mogens, Petersen, Morten Aa, Aaronson, Neil K, Arraras, Juan I, Chie, Wei-Chu, Conroy, Thierry, Costantini, Anna, Dirven, Linda, Fayers, Peter, Gamper, Eva-Maria, Giesinger, Johannes M, Habets, Esther J J, Hammerlid, Eva, Helbostad, Jorunn, Hjermstad, Marianne J, Holzner, Bernhard, Johnson, Colin, Kemmler, Georg, King, Madeleine T, Kaasa, Stein, Loge, Jon H, Reijneveld, Jaap C, Singer, Susanne, Taphoorn, Martin J B, Thamsborg, Lise H, Tomaszewski, Krzysztof A, Velikova, Galina, Verdonck-de Leeuw, Irma M, Young, Teresa, and Groenvold, Mogens
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BACKGROUND: To optimise measurement precision, relevance to patients and flexibility, patient-reported outcome measures (PROMs) should ideally be adapted to the individual patient/study while retaining direct comparability of scores across patients/studies. This is achievable using item banks and computerised adaptive tests (CATs). The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) is one of the most widely used PROMs in cancer research and clinical practice. Here we provide an overview of the research program to develop CAT versions of the QLQ-C30's 14 functional and symptom domains.METHODS: The EORTC Quality of Life Group's strategy for developing CAT item banks consists of: literature search to identify potential candidate items; formulation of new items compatible with the QLQ-C30 item style; expert evaluations and patient interviews; field-testing and psychometric analyses, including factor analysis, item response theory calibration and simulation of measurement properties. In addition, software for setting up, running and scoring CAT has been developed.RESULTS: Across eight rounds of data collections, 9782 patients were recruited from 12 countries for the field-testing. The four phases of development resulted in a total of 260 unique items across the 14 domains. Each item bank consists of 7-34 items. Psychometric evaluations indicated higher measurement precision and increased statistical power of the CAT measures compared to the QLQ-C30 scales. Using CAT, sample size requirements may be reduced by approximately 20-35% on average without loss of power.CONCLUSIONS: The EORTC CAT Core represents a more precise, powerful and flexible measurement system than the QLQ-C30. It is currently being validated in a large independent, international sample of cancer patients.
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- 2018
235. Deviant Vocal Fold Vibration as Observed During Videokymography: The Effect on Voice Quality
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Verdonck-de Leeuw, Irma M., Festen, Joost M., and Mahieu, Hans F.
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- 2001
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236. Introducing Decision Aids into Routine Prostate Cancer Care in The Netherlands: Implementation and Patient Evaluations from the Multi-regional JIPPA Initiative.
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Cuypers, Maarten, Al-Itejawi, Hoda H. M., van Uden-Kraan, Cornelia F., Stalmeier, Peep F. M., Lamers, Romy E. D., van Oort, Inge M., Somford, Diederik M., van Moorselaar, Reindert Jeroen A., Verdonck-de Leeuw, Irma M., van de Poll-Franse, Lonneke V., van Tol-Geerdink, Julia J., and de Vries, Marieke
- Abstract
Uptake of decision aids (DAs) in daily routine is low, resulting in limited knowledge about successful DA implementation at a large scale. We assessed implementation rates after multi-regional implementation of three different prostate cancer (PCa) treatment DAs and patient-perceived barriers and facilitators to use a DA. Thirty-three hospitals implemented one out of the three DAs in routine care. Implementation rates for each DA were calculated per hospital. After deciding about PCa treatment, patients (n = 1033) completed a survey on pre-formulated barriers and facilitators to use a DA. Overall DA implementation was 40%. For each DA alike, implementation within hospitals varied from incidental (< 10% of eligible patients receiving a DA) to high rates of implementation (> 80%). All three DAs were evaluated positively by patients, although concise and paper DAs yielded higher satisfaction scores compared with an elaborate online DA. Patients were most satisfied when they received the DA within a week after diagnosis. Pre-formulated barriers to DA usage were experienced by less than 10% of the patients, and most patients confirmed the facilitators. Many patients received a DA during treatment counseling, although a wide variation in uptake across hospitals was observed for each DA. Most patients were satisfied with the DA they received. Sustained implementation of DAs in clinical routine requires further encouragement and attention. [ABSTRACT FROM AUTHOR]
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- 2020
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237. Physical activity in patients with cancer: self-report versus accelerometer assessments.
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Douma, Joeri A.J., de Beaufort, Maaike B., Kampshoff, Caroline S., Persoon, Saskia, Vermaire, Jorine A., Chinapaw, Mai J., van Mechelen, Willem, Nollet, Frans, Kersten, Marie José, Smit, Jan H., Verdonck-de Leeuw, Irma M., Altenburg, Teatske M., and Buffart, Laurien M.
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PHYSICAL activity ,CANCER patients ,ACCELEROMETERS ,SELF-evaluation ,ISOMETRIC exercise ,QUALITY of life ,MENTAL health ,TUMOR treatment ,ACCELEROMETRY ,EXERCISE ,RESEARCH funding ,LONGITUDINAL method - Abstract
Purpose: The level of daily physical activity in patients with cancer is frequently assessed by questionnaires, such as the Physical Activity Scale for the Elderly (PASE). Objective assessments, with for example accelerometers, may be a good alternative. The aim of this study was to investigate the agreement between the PASE questionnaire and accelerometer-assessed physical activity in a large group of patients with different types of cancer.Methods: Baseline accelerometer and PASE questionnaire data of 403 participants from the REACT (Resistance and Endurance Exercise After Chemotherapy, n = 227), the EXIST (Exercise Intervention After Stem-Cell Transplantation, n = 74), and NET-QUBIC (NEtherlands QUality of Life And Biomedical Cohort Studies In Cancer, n = 102) studies were available for the current analyses. Physical activity was assessed by the PASE questionnaire (total score) and accelerometers (total minutes per day > 100 counts). Linear mixed models regression analysis was used to assess the agreement between the PASE questionnaire and accelerometer-assessed physical activity.Results: The mean (SD) PASE score was 95.9 (75.1) points and mean (SD) time in physical activity measured with the accelerometer was 256.6 (78.8) min per day. The agreement between the PASE score and the accelerometer data was significant, but poor (standardized regression coefficient (B) = 0.36, 95%CI = 0.27; 0.44, p < 0.01).Conclusion: Agreement between the PASE questionnaire and accelerometer-assessed physical activity was poor. The poor agreement indicates that they measure different physical activity constructs and cannot be used interchangeably to assess the level of daily physical activity in patients with cancer. [ABSTRACT FROM AUTHOR]- Published
- 2020
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238. Healthcare utilization and productivity loss in glioma patients and family caregivers: the impact of treatable psychological symptoms.
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Boele, Florien W., Meads, David, Jansen, Femke, Verdonck-de Leeuw, Irma M., Heimans, Jan J., Reijneveld, Jaap C., Short, Susan C., and Klein, Martin
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Background: Gliomas are associated with significant healthcare burden, yet reports of costs are scarce. While many costs are unavoidable there may be treatable symptoms contributing to higher costs. We describe healthcare and societal costs in glioma patients at high risk for depression and their family caregivers, and explore relationships between costs and treatable symptoms. Methods: Data from a multicenter randomized trial on effects of internet-based therapy for depressive symptoms were used (NTR3223). Costs of self-reported healthcare utilization, medication use, and productivity loss were calculated for patients and caregivers separately. We used generalized linear regression models to predict costs with depressive symptoms, fatigue, cognitive complaints, tumor grade (low-/high-grade), disease status (stable or active/progression), and intervention (use/non-use) as predictors. Results: Multiple assessments from baseline through 12 months from 91 glioma patients and 46 caregivers were used. Mean overall costs per year were M = €20,587.53 (sd = €30,910.53) for patients and M = €5,581.49 (sd = €13,102.82) for caregivers. In patients, higher healthcare utilization costs were associated with more depressive symptoms; higher medication costs were associated with active/progressive disease. In caregivers, higher overall costs were linked with increased caregiver fatigue, cognitive complaints, and lower patient tumor grade. Higher healthcare utilization costs were related to more cognitive complaints and lower tumor grade. More productivity loss costs were associated with increased fatigue (all P < 0.05). Conclusions: There are substantial healthcare and societal costs for glioma patients and caregivers. Associations between costs and treatable psychological symptoms indicate that possibly, adequate support could decrease costs. Trial registration: Netherlands Trial Register NTR3223. [ABSTRACT FROM AUTHOR]
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- 2020
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239. Efficacy and cost-utility of the eHealth self-management application 'Oncokompas', helping partners of patients with incurable cancer to identify their unmet supportive care needs and to take actions to meet their needs: a study protocol of a randomized controlled trial.
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Schuit, Anouk S., Holtmaat, Karen, Hooghiemstra, Nienke, Jansen, Femke, Lissenberg-Witte, Birgit I., Coupé, Veerle M. H., and Verdonck-de Leeuw, Irma M.
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RANDOMIZED controlled trials ,TELEMEDICINE ,BURDEN of care ,SERVICES for caregivers ,CANCER patients ,QUALITY of life - Abstract
Background: Incurable cancer does not only affect patients, it also affects the lives of their partners. Many partners take on caregiving responsibilities. The burden of these caregiving tasks are often associated with physical, psychological, and social difficulties and many partners have unmet supportive care needs. Oncokompas is an eHealth self-management application to support partners in finding and obtaining optimal supportive care, tailored to their quality of life and personal preferences. A randomized controlled trial will be carried out to determine the efficacy and cost-utility of Oncokompas.Methods: A total of 136 adult partners of patients with incurable cancer will be included. Partners will be randomly assigned to the intervention group, which directly gets access to Oncokompas, or the waiting-list control group, which gets access to Oncokompas after three months. The primary outcome measure is caregiver burden. Secondary outcome measures comprise self-efficacy, health-related quality of life, and costs. Measures will be assessed at baseline, two weeks after randomization, and three months after the baseline measurement.Discussion: This study will result in evidence on the efficacy and cost-utility of Oncokompas among partners of patients with incurable cancer, which might lead to implementation of Oncokompas as a health service for partners of patients with incurable cancer.Trial Registration: Netherlands Trial Register, NTR 7636. Registered on 23 November 2018. [ABSTRACT FROM AUTHOR]- Published
- 2020
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240. Health-related and cancer-related Internet use by patients treated with total laryngectomy.
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van Uden-Kraan, Cornelia F., Jansen, Femke, Lissenberg-Witte, Birgit I., Eerenstein, Simone E. J., Leemans, C. René, and Verdonck-de Leeuw, Irma M.
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INTERNET ,LOGISTIC regression analysis ,INTERNET searching ,INTERNET users - Abstract
Objectives: To investigate among patients treated with a total laryngectomy (TL) (1) Internet-use and Internet use to search for information on health and cancer (content); (2) which patients are most likely to use the Internet in general, for health-related and cancer-related purposes; (3) which other types of eHealth (community, communication, care) are used; and (4) preferences towards future use.Methods: Patient members of the Dutch TL patient society were asked to complete a questionnaire on Internet use, health-related and cancer-related Internet use, types of eHealth, preferences towards future use, socio-demographics, clinical factors, and quality of life (QOL). Factors associated with Internet use and health-related and cancer-related Internet use were investigated using stepwise logistic regression analysis.Results: In total, 279 TL patients participated, of whom 68% used the Internet. Of these, 63% used the Internet to search for information on health and 49% on cancer. Younger and higher educated TL patients and those with better QOL used the Internet more often. Patients with worse QOL searched more often for health-related information. Younger patients and those with shorter time since TL searched more often for cancer-related information. The current use of eHealth for communication, community, and care purposes among Internet users was limited (range, 2 to 15%). Many were interested in using these types of eHealth in the future (range, 21 to 72%).Conclusion: The majority used the Internet, especially to search for information on health and cancer, but only few for communication, community, or care purposes. Many were interested in future use. [ABSTRACT FROM AUTHOR]- Published
- 2020
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241. Prevalence of adjustment disorder among cancer patients, and the reach, effectiveness, cost-utility and budget impact of tailored psychological treatment: study protocol of a randomized controlled trial.
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van Beek, Florie E., Wijnhoven, Lonneke M. A., Jansen, Femke, Custers, José A. E., Aukema, Eline J., Coupé, Veerle M. H., Cuijpers, Pim, van der Lee, Marije L., Lissenberg-Witte, Birgit I., Wijnen, Ben, Prins, Judith B., and Verdonck-de Leeuw, Irma M.
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- 2019
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242. Body changes after cancer: female cancer patients' perceived social support and their perspective on care.
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Melissant, Heleen C., van Uden-Kraan, Cornelia F., Lissenberg-Witte, Birgit I., and Verdonck-de Leeuw, Irma M.
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SOCIAL support ,WOMEN patients ,CANCER patients ,MEDICAL personnel ,RELATIONSHIP status ,TUMORS & psychology ,BODY image ,CROSS-sectional method - Abstract
Purpose: The aim of this study was to investigate among female cancer patients their perceived social support from health care professionals (HCPs), family and friends, and public media, and their perspective on care concerning body changes.Methods: A study-specific questionnaire was completed by 235 female cancer patients. Descriptive statistics were used to describe social support and perspective on care. Logistic regression analyses were used to investigate the associations between social support and sociodemographic and clinical factors, psychosocial impact, and importance of appearance.Results: More than half of the patients received sufficient support from HCPs (54%) and family and friends (55%), and a third from the media (32%). Higher educated patients and those who found appearance not important during illness perceived lower support from HCPs. Patients without a partner, and those with a surgical treatment only, perceived lower support from family and friends. Patients who were older, higher educated, without a partner, and those who found appearance not important during illness perceived lower support from the media. In total, 15-50% of the patients received sufficient care for different domains of body changes. Patients expressed the highest need for psychological support (28%) and nutrition (28%).Conclusions: Half of the female cancer patients reported to receive sufficient social support concerning body changes after cancer. Perceived support depended on age, education, relationship status, and treatment modality. The need for more care was moderate. [ABSTRACT FROM AUTHOR]- Published
- 2019
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243. Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis
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Buffart, Laurien M, primary, Sweegers, Maike G, additional, May, Anne M, additional, Chinapaw, Mai J, additional, van Vulpen, Jonna K, additional, Newton, Rob U, additional, Galvão, Daniel A, additional, Aaronson, Neil K, additional, Stuiver, Martijn M, additional, Jacobsen, Paul B, additional, Verdonck-de Leeuw, Irma M, additional, Steindorf, Karen, additional, Irwin, Melinda L, additional, Hayes, Sandi, additional, Griffith, Kathleen A, additional, Lucia, Alejandro, additional, Herrero-Roman, Fernando, additional, Mesters, Ilse, additional, van Weert, Ellen, additional, Knoop, Hans, additional, Goedendorp, Martine M, additional, Mutrie, Nanette, additional, Daley, Amanda J, additional, McConnachie, Alex, additional, Bohus, Martin, additional, Thorsen, Lene, additional, Schulz, Karl-Heinz, additional, Short, Camille E, additional, James, Erica L, additional, Plotnikoff, Ronald C, additional, Arbane, Gill, additional, Schmidt, Martina E, additional, Potthoff, Karin, additional, van Beurden, Marc, additional, Oldenburg, Hester S, additional, Sonke, Gabe S, additional, van Harten, Wim H, additional, Garrod, Rachel, additional, Schmitz, Kathryn H, additional, Winters-Stone, Kerri M, additional, Velthuis, Miranda J, additional, Taaffe, Dennis R, additional, van Mechelen, Willem, additional, José Kersten, Marie, additional, Nollet, Frans, additional, Wenzel, Jennifer, additional, Wiskemann, Joachim, additional, Brug, Johannes, additional, and Courneya, Kerry S, additional
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- 2018
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244. The EORTC CAT Core—The computer adaptive version of the EORTC QLQ-C30 questionnaire
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Petersen, Morten Aa., primary, Aaronson, Neil K., additional, Arraras, Juan I., additional, Chie, Wei-Chu, additional, Conroy, Thierry, additional, Costantini, Anna, additional, Dirven, Linda, additional, Fayers, Peter, additional, Gamper, Eva-Maria, additional, Giesinger, Johannes M., additional, Habets, Esther J.J., additional, Hammerlid, Eva, additional, Helbostad, Jorunn, additional, Hjermstad, Marianne J., additional, Holzner, Bernhard, additional, Johnson, Colin, additional, Kemmler, Georg, additional, King, Madeleine T., additional, Kaasa, Stein, additional, Loge, Jon H., additional, Reijneveld, Jaap C., additional, Singer, Susanne, additional, Taphoorn, Martin J.B., additional, Thamsborg, Lise H., additional, Tomaszewski, Krzysztof A., additional, Velikova, Galina, additional, Verdonck-de Leeuw, Irma M., additional, Young, Teresa, additional, and Groenvold, Mogens, additional
- Published
- 2018
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245. The need for information among patients with hematological malignancies: Psychometric analyses of the 62-item Hematology Information Needs Questionnaire (HINQ-62)
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Rood, Janneke A. J., primary, Lissenberg-Witte, Birgit I., additional, Eeltink, Corien, additional, Stam, Frank, additional, van Zuuren, Florence J., additional, Zweegman, Sonja, additional, and Verdonck- de Leeuw, Irma M., additional
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- 2018
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246. Depressive symptoms in relation to overall survival in people with head and neck cancer: A longitudinal cohort study
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Jansen, Femke, primary, Verdonck-de Leeuw, Irma M., additional, Cuijpers, Pim, additional, Leemans, C. René, additional, Waterboer, Tim, additional, Pawlita, Michael, additional, Penfold, Chris, additional, Thomas, Steven J., additional, Waylen, Andrea, additional, and Ness, Andrew R., additional
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- 2018
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247. The efficacy of Life Review Therapy combined with Memory Specificity Training (LRT-MST) targeting cancer patients in palliative care: A randomized controlled trial
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Kleijn, Gitta, primary, Lissenberg-Witte, Birgit I., additional, Bohlmeijer, Ernst T., additional, Steunenberg, Bas, additional, Knipscheer-Kuijpers, Kitty, additional, Willemsen, Vincent, additional, Becker, Annemarie, additional, Smit, Egbert F., additional, Eeltink, Corien M., additional, Bruynzeel, Anna M. E., additional, van der Vorst, Maurice, additional, de Bree, Remco, additional, Leemans, C. René, additional, van den Brekel, Michiel W. M., additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M., additional
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- 2018
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248. A systematic review of the measurement properties of the European Organisation for Research and Treatment of Cancer In-patient Satisfaction with Care Questionnaire, the EORTC IN-PATSAT32
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Neijenhuijs, Koen I., primary, Jansen, Femke, additional, Aaronson, Neil K., additional, Brédart, Anne, additional, Groenvold, Mogens, additional, Holzner, Bernhard, additional, Terwee, Caroline B., additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M., additional
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- 2018
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249. Cost-utility analysis of meaning-centered group psychotherapy for cancer survivors
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van der Spek, Nadia, primary, Jansen, Femke, additional, Holtmaat, Karen, additional, Vos, Joël, additional, Breitbart, William, additional, van Uden-Kraan, Cornelia F., additional, Tollenaar, Rob A.E.M., additional, Cuijpers, Pim, additional, Coupé, Veerle M.H., additional, and Verdonck-de Leeuw, Irma M., additional
- Published
- 2018
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250. A systematic review of the measurement properties of the Body Image Scale (BIS) in cancer patients
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Melissant, Heleen C., primary, Neijenhuijs, Koen I., additional, Jansen, Femke, additional, Aaronson, Neil K., additional, Groenvold, Mogens, additional, Holzner, Bernhard, additional, Terwee, Caroline B., additional, van Uden-Kraan, Cornelia F., additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M., additional
- Published
- 2018
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