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204. Data descriptor: High resolution annual average air pollution concentration maps for the Netherlands

Author

Landdegradatie en aardobservatie, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, One Health Chemisch, dIRAS RA-I&I RA, Social Urban Transitions, Landscape functioning, Geocomputation and Hydrology, Schmitz, Oliver, Beelen, Rob, Strak, Maciek, Hoek, Gerard, Soenario, Ivan, Brunekreef, Bert, Vaartjes, Ilonca, Dijst, Martin J., Grobbee, Diederick E., Karssenberg, Derek, Landdegradatie en aardobservatie, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, One Health Chemisch, dIRAS RA-I&I RA, Social Urban Transitions, Landscape functioning, Geocomputation and Hydrology, Schmitz, Oliver, Beelen, Rob, Strak, Maciek, Hoek, Gerard, Soenario, Ivan, Brunekreef, Bert, Vaartjes, Ilonca, Dijst, Martin J., Grobbee, Diederick E., and Karssenberg, Derek

Published
2019

205. Trends in systolische bloeddruk in de Longitudinal Aging Study Amsterdam (LASA) tussen 1995 en 2016.

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7B, UMC Utrecht, de Boer, Annemarijn, Bots, Michiel, Bots, Michael L, Vaartjes, Ilonca, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7B, UMC Utrecht, de Boer, Annemarijn, Bots, Michiel, Bots, Michael L, and Vaartjes, Ilonca

Published
2019

206. Kerncijfers over hart- en vaatziekten.

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 7B, Julius Centrum, UMC Utrecht, de Boer, Annemarijn, Bots, Michiel, dis, I., Vaartjes, I, Visseren, F., van Dis, I., Vaartjes, Ilonca, Bots, Michael L, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 7B, Julius Centrum, UMC Utrecht, de Boer, Annemarijn, Bots, Michiel, dis, I., Vaartjes, I, Visseren, F., van Dis, I., Vaartjes, Ilonca, and Bots, Michael L

Published
2019

207. Sex differences in stroke metrics among Southeast Asian countries: Results from the Global Burden of Disease Study 2015

Author

Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Hwong, Wen Yea, Bots, Michiel L, Selvarajah, Sharmini, Sivasampu, Sheamini, Reidpath, Daniel D, Law, Wan Chung, Musa, Kamarul Imran, Vaartjes, Ilonca, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Hwong, Wen Yea, Bots, Michiel L, Selvarajah, Sharmini, Sivasampu, Sheamini, Reidpath, Daniel D, Law, Wan Chung, Musa, Kamarul Imran, and Vaartjes, Ilonca

Published
2019

208. High resolution annual average air pollution concentration maps for the Netherlands

Author

Public Health Practice, Epi Infectieziekten Team 3, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, Schmitz, Oliver, Beelen, Rob, Strak, Maciej, Hoek, Gerard, Soenario, Ivan, Brunekreef, Bert, Vaartjes, Ilonca, Dijst, Martin J., Grobbee, Diederick E., Karssenberg, Derek, Public Health Practice, Epi Infectieziekten Team 3, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, Schmitz, Oliver, Beelen, Rob, Strak, Maciej, Hoek, Gerard, Soenario, Ivan, Brunekreef, Bert, Vaartjes, Ilonca, Dijst, Martin J., Grobbee, Diederick E., and Karssenberg, Derek

Published
2019

210. Relations between air pollution and vascular development in 5-year old children: A cross-sectional study in the Netherlands

Author

Cardiovasculaire Epi Team 7B, Cardiovasculaire Epi Team 10, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, Cardiovasculaire Epi Team 4, Speerpunt Child Health, Longziekten patientenzorg, Child Health, Infection & Immunity, Public Health Practice, Ntarladima, Anna Maria, Vaartjes, Ilonca, Grobbee, Diederick E., Dijst, Martin, Schmitz, Oliver, Uiterwaal, Cuno, Dalmeijer, Geertje, Van Der Ent, Cornelis, Hoek, Gerard, Karssenberg, Derek, Cardiovasculaire Epi Team 7B, Cardiovasculaire Epi Team 10, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, Cardiovasculaire Epi Team 4, Speerpunt Child Health, Longziekten patientenzorg, Child Health, Infection & Immunity, Public Health Practice, Ntarladima, Anna Maria, Vaartjes, Ilonca, Grobbee, Diederick E., Dijst, Martin, Schmitz, Oliver, Uiterwaal, Cuno, Dalmeijer, Geertje, Van Der Ent, Cornelis, Hoek, Gerard, and Karssenberg, Derek

Published
2019

211. Mortality After First Hospital Admission for Inflammatory Bowel Disease: A Nationwide Registry Linkage Study

Author

MS MDL 1, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Opstelten, Jorrit L., Vaartjes, Ilonca, Bots, Michiel L., Oldenburg, Bas, MS MDL 1, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Opstelten, Jorrit L., Vaartjes, Ilonca, Bots, Michiel L., and Oldenburg, Bas

Published
2019

212. Increased mortality and hospital readmission risk in patients with dementia and a history of cardiovascular disease: results from a nationwide registry linkage study

Author

Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Geriatrie, van de Vorst, Irene E, Vaartjes, Ilonca, Bots, Michiel L, Koek, Huiberdina L, Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Geriatrie, van de Vorst, Irene E, Vaartjes, Ilonca, Bots, Michiel L, and Koek, Huiberdina L

Published
2019

213. Trends in the risk of cardiovascular disease in women with breast cancer in a Dutch nationwide cohort study

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, MS Radiotherapie, Cancer, Cardiovasculaire Epi Team 9, Trialbureau Beeld, Epi Kanker Team A, Buddeke, Josefien, Gernaat, Sofie A. M., Bots, Michiel L., van den Bongard, Desiree H. J. G., Grobbee, Diederick E., Vaartjes, Ilonca, Verkooijen, Helena M., Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, MS Radiotherapie, Cancer, Cardiovasculaire Epi Team 9, Trialbureau Beeld, Epi Kanker Team A, Buddeke, Josefien, Gernaat, Sofie A. M., Bots, Michiel L., van den Bongard, Desiree H. J. G., Grobbee, Diederick E., Vaartjes, Ilonca, and Verkooijen, Helena M.

Published
2019

214. Comorbidity in patients with cardiovascular disease in primary care: A cohort study with routine healthcare data

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Interne Geneeskunde Vasculaire, HAG Hart- Vaatziekten, Buddeke, Josefien, Bots, Michiel L., Van Dis, Ineke, Visseren, Frank L.J., Hollander, Monika, Schellevis, François G., Vaartjes, Ilonca, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Interne Geneeskunde Vasculaire, HAG Hart- Vaatziekten, Buddeke, Josefien, Bots, Michiel L., Van Dis, Ineke, Visseren, Frank L.J., Hollander, Monika, Schellevis, François G., and Vaartjes, Ilonca

Published
2019

216. Risk for Heart Failure: The Opportunity for Prevention With the American Heart Association's Life's Simple 7

Author

UMC Utrecht, Cardiovasculaire Epi Team 7B, Cardiovasculaire Epi Team 9, Arts Assistenten Cardiologie, Regenerative Medicine and Stem Cells, Julius Centrum, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Cardiovasculaire Epidemiologie, Team Medisch, Directie Raad van Bestuur, General Practice & Nursing Science, Cardiovasculaire Epi Team 1, Uijl, Alicia, Koudstaal, Stefan, Vaartjes, Ilonca, Boer, Jolanda M.A., Verschuren, W. M.Monique, van der Schouw, Yvonne T., Asselbergs, Folkert W., Hoes, Arno W., Sluijs, Ivonne, UMC Utrecht, Cardiovasculaire Epi Team 7B, Cardiovasculaire Epi Team 9, Arts Assistenten Cardiologie, Regenerative Medicine and Stem Cells, Julius Centrum, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Cardiovasculaire Epidemiologie, Team Medisch, Directie Raad van Bestuur, General Practice & Nursing Science, Cardiovasculaire Epi Team 1, Uijl, Alicia, Koudstaal, Stefan, Vaartjes, Ilonca, Boer, Jolanda M.A., Verschuren, W. M.Monique, van der Schouw, Yvonne T., Asselbergs, Folkert W., Hoes, Arno W., and Sluijs, Ivonne

Published
2019

217. Determinants of coronary artery disease risk factor management across three world regions

Author

UMC Utrecht, Global Health team 1, Circulatory Health, Cardiovasculaire Epi Team 9, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Global Health, Zhao, Min, Graham, Ian, Cooney, Marie Therese, Grobbee, Diederick E., Vaartjes, Ilonca, Klipstein-Grobusch, Kerstin, UMC Utrecht, Global Health team 1, Circulatory Health, Cardiovasculaire Epi Team 9, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Global Health, Zhao, Min, Graham, Ian, Cooney, Marie Therese, Grobbee, Diederick E., Vaartjes, Ilonca, and Klipstein-Grobusch, Kerstin

Published
2019

219. Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Author

Brazel, David M., Jiang, Yu, Hughey, Jordan M., Turcot, Valerie, Zhan, Xiaowei, Gong, Jian, Batini, Chiara, Weissenkampen, J. Dylan, Liu, MengZhen, Barnes, Daniel R., Bertelsen, Sarah, Chou, Yi-Ling, Erzurumluoglu, A. Mesut, Faul, Jessica D., Haessler, Jeff, Hammerschlag, Anke R., Hsu, Chris, Kapoor, Manav, Lai, Dongbing, Le, Nhung, de Leeuw, Christiaan A., Loukola, Anu, Mangino, Massimo, Melbourne, Carl A., Pistis, Giorgio, Qaiser, Beenish, Rohde, Rebecca, Shao, Yaming, Stringham, Heather, Wetherill, Leah, Zhao, Wei, Agrawal, Arpana, Bierut, Laura, Chen, Chu, Eaton, Charles B., Goate, Alison, Haiman, Christopher, Heath, Andrew, Iacono, William G., Martin, Nicholas G., Polderman, Tinca J., Reiner, Alex, Rice, John, Schlessinger, David, Scholte, H. Steven, Smith, Jennifer A., Tardif, Jean-Claude, Tindle, Hilary A., van der Leij, Andries R., Boehnke, Michael, Chang-Claude, Jenny, Cucca, Francesco, David, Sean P., Foroud, Tatiana, Howson, Joanna M. M., Kardia, Sharon L. R., Kooperberg, Charles, Laakso, Markku, Lettre, Guillaume, Madden, Pamela, Mcgue, Matt, North, Kari, Posthuma, Danielle, Spector, Timothy, Stram, Daniel, Tobin, Martin D., Weir, David R., Kaprio, Jaakko, Abecasis, Goncalo R., Liu, Dajiang J., Vrieze, Scott, Surendran, Praveen, Young, Robin, Nielsen, Sune Fallgaard, Rasheed, Asif, Samuel, Maria, Kontto, Jukka, Perola, Markus, Caslake, Muriel, de Craen, Anton J. M., Trompet, Stella, Uria-Nickelsen, Maria, Malarstig, Anders, Reily, Dermot F., Hoek, Maarten, Vogt, Thomas, Jukema, J. Wouter, Sattar, Naveed, Ford, Ian, Packard, Chris J., Alam, Dewan S., Majumder, Abdulla al Shafi, Di Ange-Lantonio, Emanuele, Chowdhury, Rajiv, Amouyel, Philippe, Arveiler, Dominique, Blankenberg, Stefan, Ferrieres, Jean, Kee, Frank, Kuulasmaa, Kari, Mueller-Nurasyid, Martina, Veronesi, Giovanni, Virtamo, Jarmo, Frossard, Philippe, Nordestgaard, Borge Gronne, Saleheen, Danish, Danesh, John, Butterworth, Adam S., Jackson, Victoria E., Varga, Tibor V., Warren, Helen R., Tragante, Vinicius, Tachmazidou, Ioanna, Harris, Sarah E., Evangelou, Evangelos, Marten, Jonathan, Zhang, Weihua, Altmaier, Elisabeth, Luan, Jian'an, Langenberg, Claudia, Scott, Robert A., Yaghootkar, Hanieh, Stirrups, Kathleen, Kanoni, Stavroula, Marouli, Eirini, Karpe, Fredrik, Dominiczak, Anna F., Sever, Peter, Poulter, Neil, Rolandsson, Olov, Baumbach, Clemens, Afaq, Saima, Chambers, John C., Kooner, Jaspal S., Wareham, Nicholas J., Renstrom, Frida, Hallmans, Goran, Marioni, Riccardo E., Corley, Janie, Starr, John M., Verweij, Niek, de Boer, Rudolf A., van der Meer, Peter, Yavas, Ersin, Vaartjes, Ilonca, Bots, Michiel L., Asselbergs, Folkert W., Grabe, Hans J., Volzke, Henry, Nauck, Matthias, Weiss, Stefan, Pharoah, Paul D. P., Dunning, Alison M., Dennis, Joe G., Thompson, Deborah J., Michailidou, Kyriaki, Easton, Douglas F., Antoniou, Antonis C., Tyrrell, Jessica, Mihailov, Evelin, Samani, Nilesh J., Zhou, Kaixin, Neville, Matthew J., Metspalu, Andres, Palmer, Colin N. A., Hall, Ian P., Strachan, David P., Deary, Ian J., Frayling, Tim M., Hayward, Caroline, van der Harst, Pim, Zeggini, Eleftheria, Munroe, Patricia B., Jansson, Jan-Hakan, Franks, Paul W., Deloukas, Panos, Caulfield, Mark J., Wain, Louise V., Brazel, David M., Jiang, Yu, Hughey, Jordan M., Turcot, Valerie, Zhan, Xiaowei, Gong, Jian, Batini, Chiara, Weissenkampen, J. Dylan, Liu, MengZhen, Barnes, Daniel R., Bertelsen, Sarah, Chou, Yi-Ling, Erzurumluoglu, A. Mesut, Faul, Jessica D., Haessler, Jeff, Hammerschlag, Anke R., Hsu, Chris, Kapoor, Manav, Lai, Dongbing, Le, Nhung, de Leeuw, Christiaan A., Loukola, Anu, Mangino, Massimo, Melbourne, Carl A., Pistis, Giorgio, Qaiser, Beenish, Rohde, Rebecca, Shao, Yaming, Stringham, Heather, Wetherill, Leah, Zhao, Wei, Agrawal, Arpana, Bierut, Laura, Chen, Chu, Eaton, Charles B., Goate, Alison, Haiman, Christopher, Heath, Andrew, Iacono, William G., Martin, Nicholas G., Polderman, Tinca J., Reiner, Alex, Rice, John, Schlessinger, David, Scholte, H. Steven, Smith, Jennifer A., Tardif, Jean-Claude, Tindle, Hilary A., van der Leij, Andries R., Boehnke, Michael, Chang-Claude, Jenny, Cucca, Francesco, David, Sean P., Foroud, Tatiana, Howson, Joanna M. M., Kardia, Sharon L. R., Kooperberg, Charles, Laakso, Markku, Lettre, Guillaume, Madden, Pamela, Mcgue, Matt, North, Kari, Posthuma, Danielle, Spector, Timothy, Stram, Daniel, Tobin, Martin D., Weir, David R., Kaprio, Jaakko, Abecasis, Goncalo R., Liu, Dajiang J., Vrieze, Scott, Surendran, Praveen, Young, Robin, Nielsen, Sune Fallgaard, Rasheed, Asif, Samuel, Maria, Kontto, Jukka, Perola, Markus, Caslake, Muriel, de Craen, Anton J. M., Trompet, Stella, Uria-Nickelsen, Maria, Malarstig, Anders, Reily, Dermot F., Hoek, Maarten, Vogt, Thomas, Jukema, J. Wouter, Sattar, Naveed, Ford, Ian, Packard, Chris J., Alam, Dewan S., Majumder, Abdulla al Shafi, Di Ange-Lantonio, Emanuele, Chowdhury, Rajiv, Amouyel, Philippe, Arveiler, Dominique, Blankenberg, Stefan, Ferrieres, Jean, Kee, Frank, Kuulasmaa, Kari, Mueller-Nurasyid, Martina, Veronesi, Giovanni, Virtamo, Jarmo, Frossard, Philippe, Nordestgaard, Borge Gronne, Saleheen, Danish, Danesh, John, Butterworth, Adam S., Jackson, Victoria E., Varga, Tibor V., Warren, Helen R., Tragante, Vinicius, Tachmazidou, Ioanna, Harris, Sarah E., Evangelou, Evangelos, Marten, Jonathan, Zhang, Weihua, Altmaier, Elisabeth, Luan, Jian'an, Langenberg, Claudia, Scott, Robert A., Yaghootkar, Hanieh, Stirrups, Kathleen, Kanoni, Stavroula, Marouli, Eirini, Karpe, Fredrik, Dominiczak, Anna F., Sever, Peter, Poulter, Neil, Rolandsson, Olov, Baumbach, Clemens, Afaq, Saima, Chambers, John C., Kooner, Jaspal S., Wareham, Nicholas J., Renstrom, Frida, Hallmans, Goran, Marioni, Riccardo E., Corley, Janie, Starr, John M., Verweij, Niek, de Boer, Rudolf A., van der Meer, Peter, Yavas, Ersin, Vaartjes, Ilonca, Bots, Michiel L., Asselbergs, Folkert W., Grabe, Hans J., Volzke, Henry, Nauck, Matthias, Weiss, Stefan, Pharoah, Paul D. P., Dunning, Alison M., Dennis, Joe G., Thompson, Deborah J., Michailidou, Kyriaki, Easton, Douglas F., Antoniou, Antonis C., Tyrrell, Jessica, Mihailov, Evelin, Samani, Nilesh J., Zhou, Kaixin, Neville, Matthew J., Metspalu, Andres, Palmer, Colin N. A., Hall, Ian P., Strachan, David P., Deary, Ian J., Frayling, Tim M., Hayward, Caroline, van der Harst, Pim, Zeggini, Eleftheria, Munroe, Patricia B., Jansson, Jan-Hakan, Franks, Paul W., Deloukas, Panos, Caulfield, Mark J., and Wain, Louise V.

Published
2019

220. Risk factors for in-hospital mortality in patients with dementia

Author

Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, Golüke, Nienke M S, van de Vorst, Irene E, Vaartjes, Ilonca H, Geerlings, Mirjam I, de Jonghe, Annemarieke, Bots, Michiel L, Koek, Huiberdina L, Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, Golüke, Nienke M S, van de Vorst, Irene E, Vaartjes, Ilonca H, Geerlings, Mirjam I, de Jonghe, Annemarieke, Bots, Michiel L, and Koek, Huiberdina L

Published
2019

221. Stroke incidence in young adults according to age, subtype, sex, and time trends

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Opleiding Neurologie, ZL Cerebrovasculaire Ziekten Medisch, Brain, Ekker, Merel S., Verhoeven, Jamie I., Vaartjes, Ilonca, van Nieuwenhuizen, Koen M., Klijn, Catharina J.M., de Leeuw, Frank Erik, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Opleiding Neurologie, ZL Cerebrovasculaire Ziekten Medisch, Brain, Ekker, Merel S., Verhoeven, Jamie I., Vaartjes, Ilonca, van Nieuwenhuizen, Koen M., Klijn, Catharina J.M., and de Leeuw, Frank Erik

Published
2019

223. Residential exposure to fast-food restaurants and its association with diet quality, overweight and obesity in the Netherlands: a cross-sectional analysis in the EPIC-NL cohort.

Author

Harbers, Marjolein C., Beulens, Joline W.J., Boer, Jolanda MA, Karssenberg, Derek, Mackenbach, Joreintje D., Rutters, Femke, Vaartjes, Ilonca, Verschuren, WM Monique, van der Schouw, Yvonne T., and Verschuren, W M Monique

Subjects
CROSS-sectional method, DIET, COHORT analysis, WALKABILITY, OLDER people, OUTLET stores, OBESITY
Abstract

Background: Unhealthy food environments may contribute to unhealthy diets and risk of overweight and obesity through increased consumption of fast-food. Therefore, we aimed to study the association of relative exposure to fast-food restaurants (FFR) with overall diet quality and risk of overweight and obesity in a sample of older adults.Methods: We analyzed cross-sectional data of the EPIC-NL cohort (n = 8,231). Data on relative FFR exposure was obtained through linkage of home address in 2015 with a retail outlet database. We calculated relative exposure to FFR by dividing the densities of FFR in street-network buffers of 400, 1000, and 1500 m around the home of residence by the density of all food retailers in the corresponding buffer. We calculated scores on the Dutch Healthy Diet 2015 (DHD15) index using data from a validated food-frequency questionnaire. BMI was categorized into normal weight (BMI < 25), overweight (25 ≤ BMI < 30), and obesity (BMI ≥ 30). We used multivariable linear regression (DHD15-index) and multinomial logistic regression (weight status), using quartiles of relative FFR exposure as independent variable, adjusting for lifestyle and environmental characteristics.Results: Relative FFR exposure was not significantly associated with DHD15-index scores in the 400, 1000, and 1500 m buffers (βQ4vsQ1= -0.21 [95 %CI: -1.12; 0.70]; βQ4vsQ1= -0.12 [95 %CI: -1.10; 0.87]; βQ4vsQ1 = 0.37 [95 %CI: -0.67; 1.42], respectively). Relative FFR exposure was also not related to overweight in consecutive buffers (ORQ4vsQ1=1.10 [95 %CI: 0.97; 1.25]; ORQ4vsQ1=0.97 [95 %CI: 0.84; 1.11]; ORQ4vsQ1= 1.04 [95 %CI: 0.90-1.20]); estimates for obesity were similar to those of overweight.Conclusions: A high proportion of FFR around the home of residence was not associated with diet quality or overweight and obesity in this large Dutch cohort of older adults. We conclude that although the food environment may be a determinant of food choice, this may not directly translate into effects on diet quality and weight status. Methodological improvements are warranted to provide more conclusive evidence. [ABSTRACT FROM AUTHOR]

Published
2021
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225. Neighbourhood socioeconomic inequalities in incidence of acute myocardial infarction: a cohort study quantifying age- and gender-specific differences in relative and absolute terms

Author

Koopman Carla, van Oeffelen Aloysia AM, Bots Michiel L, Engelfriet Peter M, Verschuren WM, van Rossem Lenie, van Dis Ineke, Capewell Simon, and Vaartjes Ilonca

Subjects
Coronary heart disease, Acute myocardial infarction, Incidence, Socioeconomic status, Relative, Absolute, The Netherlands, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Socioeconomic status has a profound effect on the risk of having a first acute myocardial infarction (AMI). Information on socioeconomic inequalities in AMI incidence across age- gender-groups is lacking. Our objective was to examine socioeconomic inequalities in the incidence of AMI considering both relative and absolute measures of risk differences, with a particular focus on age and gender. Methods We identified all patients with a first AMI from 1997 to 2007 through linked hospital discharge and death records covering the Dutch population. Relative risks (RR) of AMI incidence were estimated by mean equivalent household income at neighbourhood-level for strata of age and gender using Poisson regression models. Socioeconomic inequalities were also shown within the stratified age-gender groups by calculating the total number of events attributable to socioeconomic disadvantage. Results Between 1997 and 2007, 317,564 people had a first AMI. When comparing the most deprived socioeconomic quintile with the most affluent quintile, the overall RR for AMI was 1.34 (95 % confidence interval (CI): 1.32 – 1.36) in men and 1.44 (95 % CI: 1.42 – 1.47) in women. The socioeconomic gradient decreased with age. Relative socioeconomic inequalities were most apparent in men under 35 years and in women under 65 years. The largest number of events attributable to socioeconomic inequalities was found in men aged 45–74 years and in women aged 65–84 years. The total proportion of AMIs that was attributable to socioeconomic inequalities in the Dutch population of 1997 to 2007 was 14 % in men and 18 % in women. Conclusions Neighbourhood socioeconomic inequalities were observed in AMI incidence in the Netherlands, but the magnitude across age-gender groups depended on whether inequality was expressed in relative or absolute terms. Relative socioeconomic inequalities were high in young persons and women, where the absolute burden of AMI was low. Absolute socioeconomic inequalities in AMI were highest in the age-gender groups of middle-aged men and elderly women, where the number of cases was largest.

Published
2012
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226. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Author

Prins, Bram P, Mead, Timothy J, Brody, Jennifer A, Sveinbjornsson, Gardar, Ntalla, Ioanna, Bihlmeyer, Nathan A, van den Berg, Marten, Bork-Jensen, Jette, Cappellani, Stefania, Van Duijvenboden, Stefan, Klena, Nikolai T, Gabriel, George C, Liu, Xiaoqin, Gulec, Cagri, Grarup, Niels, Haessler, Jeffrey, Hall, Leanne M, Iorio, Annamaria, Isaacs, Aaron, Li-Gao, Ruifang, Lin, Honghuang, Liu, Ching-Ti, Lyytikäinen, Leo-Pekka, Marten, Jonathan, Mei, Hao, Müller-Nurasyid, Martina, Orini, Michele, Padmanabhan, Sandosh, Radmanesh, Farid, Ramirez, Julia, Robino, Antonietta, Schwartz, Molly, van Setten, Jessica, Smith, Albert V, Verweij, Niek, Warren, Helen R, Weiss, Stefan, Alonso, Alvaro, Arnar, David O, Bots, Michiel L, de Boer, Rudolf A, Dominiczak, Anna F, Eijgelsheim, Mark, Ellinor, Patrick T, Guo, Xiuqing, Felix, Stephan B, Harris, Tamara B, Hayward, Caroline, Heckbert, Susan R, Huang, Paul L, Jukema, JW, Kähönen, Mika, Kors, Jan A, Lambiase, Pier D, Launer, Lenore J, Li, Man, Linneberg, Allan, Nelson, Christopher P, Pedersen, Oluf, Perez, Marco, Peters, Annette, Polasek, Ozren, Psaty, Bruce M, Raitakari, Olli T, Rice, Kenneth M, Rotter, Jerome I, Sinner, Moritz F, Soliman, Elsayed Z, Spector, Tim D, Strauch, Konstantin, Thorsteinsdottir, Unnur, Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Vaartjes, Ilonca, van der Meer, Peter, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Wilson, James G, Xie, Zhijun, Asselbergs, Folkert W, Dörr, Marcus, van Duijn, Cornelia M, Gasparini, Paolo, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hansen, Torben, Kääb, Stefan, Kanters, Jørgen K, Kooperberg, Charles, Lehtimäki, Terho, Lin, Henry J, Lubitz, Steven A, Mook-Kanamori, Dennis O, Conti, Francesco J, Newton-Cheh, Christopher H, Rosand, Jonathan, Rudan, Igor, and Samani, Nilesh J

Subjects
Male, Bioinformatics, Gene Expression, Black People, Conduction, Cardiovascular, White People, Mice, Electrocardiography, Open Reading Frames, ADAMTS Proteins, Heart Conduction System, Information and Computing Sciences, Exome Sequencing, Genetics, Animals, Humans, 2.1 Biological and endogenous factors, Exome, Polymorphism, Aetiology, Myocardium, Gene Expression Profiling, Human Genome, Single Nucleotide, Middle Aged, Biological Sciences, Exome chip, Meta-analysis, Heart Disease, Genetic Loci, Connexin 43, ADAMTS6, Female, Environmental Sciences, Genome-Wide Association Study
Abstract

BackgroundGenome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear.ResultsHere, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in our discovery cohort, followed by replication in 111,874individuals of European ancestry from the UK Biobank and deCODE cohorts. We identify ten novel loci, seven within coding regions, including ADAMTS6, significantly associated with QRS duration in gene-based analyses. ADAMTS6 encodes a secreted metalloprotease of currently unknown function. In vitro validation analysis shows that the QRS-associated variants lead to impaired ADAMTS6 secretion and loss-of function analysis in mice demonstrates a previously unappreciated role for ADAMTS6 in connexin 43 gap junction expression, which is essential for myocardial conduction.ConclusionsOur approach identifies novel coding and non-coding variants underlying ventricular depolarization and provides a possible mechanism for the ADAMTS6-associated conduction changes.

Published
2018

227. Cardiovascular Disease Prevention Policy in Human Immunodeficiency Virus : Recommendations From a Modeling Study

Author

Smit, Mikaela, van Zoest, Rosan A, Nichols, Brooke E, Vaartjes, Ilonca, Smit, Colette, van der Valk, Marc, van Sighem, Ard I, Wit, Ferdinand W N M, Hallett, Timothy B, Reiss, Peter, and Netherlands ATHENA observational HIV cohort

Subjects
model, prevention, cardiovascular disease, cost, HIV
Abstract

Background: Cardiovascular disease (CVD) is expected to contribute a large non-communicable disease burden amongst HIV-positive people. We quantify the impact of prevention interventions on annual CVD burden and costs amongst HIV-positive people in The Netherlands. Methods: We constructed an individual-based model of CVD in HIV-positive people using national ATHENA cohort data on 8,791 patients on combination antiretroviral therapy (cART). The model follows patients as they age, develop CVD (by incorporating a CVD risk equation) and start cardiovascular medication. Four prevention interventions were evaluated: (1) increasing the rate of earlier HIV diagnosis and treatment; (2) avoiding use of cART with increased CVD risk; (3) smoking cessation; (4) intensified monitoring and drug treatment of hypertension and dyslipidaemia, quantifying annual number of averted CVDs and costs. Results: The model predicts that annual CVD incidence and costs will increase by 55% and 36% between 2015-2030. Traditional prevention interventions, i.e. smoking cessation and intensified monitoring and treatment of hypertension and dyslipidaemia, will avert the largest number of annual CVD cases (13.1% and 20.0%) compared to HIV-related interventions, i.e. earlier HIV diagnosis and treatment and avoiding cART with increased CVD risk (0.8% and 3.7%, respectively), as well as reduce cumulative CVD-related costs. Targeting high risk patients could avert the majority of events and costs. Conclusions: Traditional CVD prevention interventions can maximize cardiovascular health and defray future costs, particularly if targeting high risk patients. Quantifying additional public health benefits, beyond CVD, is likely to provide further evidence for policy development.

Published
2018

229. Additional file 2: of Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Author

Prins, Bram, Mead, Timothy, Brody, Jennifer, Gardar Sveinbjornsson, Ntalla, Ioanna, Bihlmeyer, Nathan, Berg, Marten Van Den, Bork-Jensen, Jette, Cappellani, Stefania, Duijvenboden, Stefan Van, Klena, Nikolai, Gabriel, George, Xiaoqin Liu, Cagri Gulec, Grarup, Niels, Haessler, Jeffrey, Hall, Leanne, Iorio, Annamaria, Isaacs, Aaron, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka LyytikäInen, Marten, Jonathan, Mei, Hao, Mßller-Nurasyid, Martina, Orini, Michele, Sandosh Padmanabhan, Radmanesh, Farid, Ramirez, Julia, Robino, Antonietta, Schwartz, Molly, Setten, Jessica Van, Smith, Albert, Verweij, Niek, Warren, Helen, Weiss, Stefan, Alonso, Alvaro, Arnar, David, Bots, Michiel, Boer, Rudolf De, Dominiczak, Anna, Eijgelsheim, Mark, Ellinor, Patrick, Xiuqing Guo, Felix, Stephan, Harris, Tamara, Hayward, Caroline, Heckbert, Susan, Huang, Paul, J. Jukema, KäHÜnen, Mika, Kors, Jan, Lambiase, Pier, Launer, Lenore, Li, Man, Linneberg, Allan, Nelson, Christopher, Pedersen, Oluf, Perez, Marco, Peters, Annette, Polasek, Ozren, Psaty, Bruce, Raitakari, Olli, Rice, Kenneth, Rotter, Jerome, Sinner, Moritz, Elsayed Soliman, Spector, Tim, Strauch, Konstantin, Thorsteinsdottir, Unnur, Tinker, Andrew, Trompet, Stella, AndrÊ Uitterlinden, Vaartjes, Ilonca, Meer, Peter Van Der, VÜlker, Uwe, VÜlzke, Henry, Waldenberger, Melanie, Wilson, James, Zhijun Xie, Asselbergs, Folkert, DÜrr, Marcus, Duijn, Cornelia Van, Gasparini, Paolo, Gudbjartsson, Daniel, Gudnason, Vilmundur, Hansen, Torben, KääB, Stefan, JøRgen Kanters, Kooperberg, Charles, LehtimäKi, Terho, Lin, Henry, Lubitz, Steven, Mook-Kanamori, Dennis, Conti, Francesco, Newton-Cheh, Christopher, Rosand, Jonathan, Rudan, Igor, Nilesh Samani, Sinagra, Gianfranco, Smith, Blair, Holm, Hilma, Stricker, Bruno, Ulivi, Sheila, Sotoodehnia, Nona, Suneel Apte, Harst, Pim Van Der, Stefansson, Kari, Munroe, Patricia, Arking, Dan, Lo, Cecilia, and Yalda Jamshidi

Abstract

Figure S1. Manhattan plot for European and African-American ancestry single variant analysis. Figure S2. Quantile-quantile plot for European and African-American ancestry single variant analysis. Figure S3. Manhattan plot for EA single variant analysis. Figure S4. QQ plot for EA single variant analysis. Figure S5. Manhattan plot for AA single variant analysis. Figure S6. Quantile-quantile plot for AA single variant analysis. Figure S7. Miami plot European and African-American ancestry sex-stratified single variant analysis. Figure S8. Quantile-quantile plots for European and African-American ancestry sex-stratified single variant analyses. Figure S9. Normal morphology of adult Adamts6 heterozygous hearts. (DOCX 4290 kb)

Published
2018
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230. Exome-chip association analysis of intracranial aneurysms

Author

van 't Hof, Femke N.G., primary, Lai, Dongbing, additional, van Setten, Jessica, additional, Bots, Michiel L., additional, Vaartjes, Ilonca, additional, Broderick, Joseph, additional, Woo, Daniel, additional, Foroud, Tatiana, additional, Rinkel, Gabriel J.E., additional, de Bakker, Paul I.W., additional, and Ruigrok, Ynte M., additional

Published
2019
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234. Risk for Heart Failure

Author

Uijl, Alicia, primary, Koudstaal, Stefan, additional, Vaartjes, Ilonca, additional, Boer, Jolanda M.A., additional, Verschuren, W.M. Monique, additional, van der Schouw, Yvonne T., additional, Asselbergs, Folkert W., additional, Hoes, Arno W., additional, and Sluijs, Ivonne, additional

Published
2019
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244. Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

Author

Ng, Natasha, primary, Willems, Sara M., additional, Fernandez, Juan, additional, Fine, Rebecca S., additional, Wheeler, Eleanor, additional, Wessel, Jennifer, additional, Kitajima, Hidetoshi, additional, Marenne, Gaëlle, additional, Rundle, Jana K., additional, Sim, Xueling, additional, Yeghootkar, Hanieh, additional, Beer, Nicola L., additional, Raimondo, Anne, additional, Tarasov, Andrei I., additional, Thomsen, Soren K., additional, van de Bunt, Martijn, additional, Wang, Shuai, additional, Chen, Sai, additional, Chen, Yuning, additional, Chen, Yii-Der Ida, additional, de Haan, Hugoline G., additional, Grarup, Niels, additional, Li-Gao, Ruifang, additional, Varga, Tibor V., additional, Asimit, Jennifer L, additional, Feng, Shuang, additional, Strawbridge, Rona J., additional, Kleinbrink, Erica L., additional, Ahluwalia, Tarunveer S., additional, An, Ping, additional, Appel, Emil V., additional, Arking, Dan E, additional, Auvinen, Juha, additional, Bielak, Lawrence F., additional, Bihlmeyer, Nathan A., additional, Bork-Jensen, Jette, additional, Brody, Jennifer A., additional, Campbell, Archie, additional, Chu, Audrey Y, additional, Davies, Gail, additional, Demirkan, Ayse, additional, Floyd, James S., additional, Giulianini, Franco, additional, Guo, Xiuqing, additional, Gustafsson, Stefan, additional, Hastoy, Benoit, additional, Jackson, Anne U., additional, Jakobsdottir, Johanna, additional, Järvelin, Marjo-Riitta, additional, Jensen, Richard A., additional, Kanoni, Stavroula, additional, Keinanen-Kiukaanniemi, Sirkka, additional, Li, Jin, additional, Li, Man, additional, Lohman, Kurt, additional, Lu, Yingchang, additional, Luan, Jian’an, additional, Manning, Alisa K., additional, Marten, Jonathan, additional, Marzi, Carola, additional, Meidtner, Karina, additional, Mook-Kanamori, Dennis O., additional, Muka, Taulant, additional, Pistis, Giorgio, additional, Prins, Bram, additional, Rice, Kenneth M., additional, Robertson, Neil, additional, Sanna, Serena, additional, Shi, Yuan, additional, Smith, Albert Vernon, additional, Smith, Jennifer A., additional, Southam, Lorraine, additional, Stringham, Heather M., additional, Tajuddin, Salman M., additional, Tragante, Vinicius, additional, van der Laan, Sander W., additional, Warren, Helen R., additional, Yao, Jie, additional, Yiorkas, Andrianos M., additional, Zhang, Weihua, additional, Zhao, Wei, additional, Ahlqvist, Emma, additional, Graff, Mariaelisa, additional, Highland, Heather M., additional, Justice, Anne E., additional, Lo, Ken Sin, additional, Marouli, Eirini, additional, Medina-Gomez, Carolina, additional, Afaq, Saima, additional, Alhejily, Wesam A., additional, Amin, Najaf, additional, Asselbergs, Folkert W., additional, Bonnycastle, Lori L., additional, Bots, Michiel L., additional, Brandslund, Ivan, additional, Chen, Ji, additional, Christensen, Cramer, additional, Danesh, John, additional, de Mutsert, Renée, additional, Dehghan, Abbas, additional, Ebeling, Tapani, additional, Elliott, Paul, additional, Consortium, EPIC-InterAct, additional, Farmaki, Aliki-Eleni, additional, Faul, Jessica D., additional, Franks, Paul W., additional, Franks, Steve, additional, Fritsche, Andreas, additional, Gjesing, Anette P., additional, Goodarzi, Mark O., additional, Gudnason, Vilmundur, additional, Hallmans, Göran, additional, Harris, Tamara B., additional, Herzig, Karl-Heinz, additional, Hivert, Marie-France, additional, Jansson, Jan-Håkan, additional, Jhun, Min A., additional, Beck Jørgensen, Torben, additional, Jørgensen, Marit E., additional, Jousilahti, Pekka, additional, Kajantie, Eero, additional, Karaleftheri, Maria, additional, Kardia, Sharon L.R., additional, Kinnunen, Leena, additional, Koistinena, Heikki A., additional, Komulainen, Pirjo, additional, Kovacs, Peter, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lange, Leslie A., additional, Launer, Lenore J., additional, Lee, Jung-Jin, additional, Leong, Aaron, additional, Lindström, Jaana, additional, Fox, Jocelyn E. Manning, additional, Männistö, Satu, additional, Maruthur, Nisa M., additional, Moilanen, Leena, additional, Mulas, Antonella, additional, Nalls, Mike A., additional, Neville, Matthew, additional, Pankow, James S., additional, Pattie, Alison, additional, Petersen, Eva R. B., additional, Puolijoki, Hannu, additional, Rasheed, Asif, additional, Redmond, Paul, additional, Renström, Frida, additional, Roden, Michael, additional, Saleheen, Danish, additional, Saltevo, Juha, additional, Savonen, Kai, additional, Sébert, Sylvain P., additional, Skaaby, Tea, additional, Small, Kerrin S., additional, Stančáková, Alena, additional, Stokholm, Jakob, additional, Strauch, Konstantin, additional, Tai, E-Shyong, additional, Taylor, Kent D., additional, Thuesen, Betina H., additional, Tönjes, Anke, additional, Tsafantakis, Emmanouil, additional, Tuomi, Tiinamaija, additional, Tuomilehto, Jaakko, additional, Group, Understanding Society Scientific, additional, Uusitupa, Matti I., additional, Vääräsmäki, Marja, additional, Vaartjes, Ilonca, additional, Zoledziewska, Magdalena, additional, Abecasis, Goncalo, additional, Balkau, Beverley, additional, Bisgaard, Hans, additional, Blakemore, Alexandra I., additional, Blüher, Matthias, additional, Boeing, Heiner, additional, Boerwinkle, Eric, additional, Bønnelykke, Klaus, additional, Bottinger, Erwin P., additional, Caulfield, Mark J., additional, Chambers, John C., additional, Chasman, Daniel I., additional, Cheng, Ching-Yu, additional, Clark, Anne, additional, Collins, Francis S., additional, Coresh, Josef, additional, Cucca, Francesco, additional, de Borst, Gert J., additional, Deary, Ian J., additional, Dedoussis, George, additional, Deloukas, Panos, additional, den Ruijter, Hester M., additional, Dupuis, Josée, additional, Evans, Michele K., additional, Ferrannini, Ele, additional, Franco, Oscar H., additional, Grallert, Harald, additional, Groop, Leif, additional, Hansen, Torben, additional, Hattersley, Andrew T., additional, Hayward, Caroline, additional, Hirschhorn, Joel N., additional, Ikram, M. Arfan, additional, Ingelsson, Erik, additional, Karpe, Fredrik, additional, Kaw, Kay-Tee, additional, Kiess, Wieland, additional, Kooner, Jaspal S., additional, Körner, Antje, additional, Lakka, Timo, additional, Langenberg, Claudia, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Linneberg, Allan, additional, Lipovich, Leonard, additional, Liu, Ching-Ti, additional, Liu, Jun, additional, Liu, Yongmei, additional, Loos, Ruth J. F., additional, MacDonald, Patrick E., additional, Mohlke, Karen L., additional, Morris, Andrew D., additional, Munroe, Patricia B., additional, Murray, Alison, additional, Padmanabhan, Sandosh, additional, Palmer, Colin N. A., additional, Pasterkamp, Gerard, additional, Pedersen, Oluf, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Porteous, David, additional, Province, Michael A., additional, Psaty, Bruce M., additional, Rauramaa, Rainer, additional, Ridker, Paul M., additional, Rolandsson, Olov, additional, Rorsman, Patrik, additional, Rosendaal, Frits, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Schulze, Matthias B., additional, Sladek, Robert, additional, Smith, Blair H., additional, Spector, Timothy D., additional, Starr, John M., additional, Stumvoll, Michael, additional, van Duijn, Cornelia M., additional, Walker, Mark, additional, Wareham, Nick J., additional, Weir, David R., additional, Wilson, James G., additional, Wong, Tien Yin, additional, Zeggini, Eleftheria, additional, Zonderman, Alan B., additional, Rotter, Jerome I., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Florez, Jose, additional, McCarthy, Mark I., additional, Meigs, James B., additional, Mahajan, Anubha, additional, Scott, Robert A., additional, Gloyn, Anna L., additional, and Barroso, Ines, additional

Published
2019
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245. Associations between the fast-food environment and diabetes prevalence in the Netherlands: a cross-sectional study

Author

Ntarladima, Anna-Maria, Karssenberg, Derek, Poelman, Maartje, Grobbee, Diederick E, Lu, Meng, Schmitz, Oliver, Strak, Maciej, Janssen, Nicole, Hoek, Gerard, and Vaartjes, Ilonca

Abstract

Diabetes is a major health concern and is influenced by lifestyle, which can be affected by the neighbourhood environment. Specifically, a fast-food environment can influence eating behaviours and thus diabetes prevalence. Therefore, our aim was to assess the relationship between fast-food environment and diabetes prevalence for urban and rural environments in the Netherlands, using multiple indicators and buffer sizes.

Published
2022
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246. Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

Author

Piepoli, Massimo F, Adamo, Marianna, Barison, Andrea, Bestetti, Reinaldo B, Biegus, Jan, Böhm, Michael, Butler, Javed, Carapetis, Jonathan, Ceconi, Claudio, Chioncel, Ovidiu, Coats, Andrew, Crespo-Leiro, Maria G, de Simone, Giovanni, Drexel, Heinz, Emdin, Michele, Farmakis, Dimitros, Halle, Martin, Heymans, Stephane, Jaarsma, Tiny, Jankowska, Ewa, Lainscak, Mitja, Lam, Carolyn S P, Løchen, Maja-Lisa, Lopatin, Yuri, Maggioni, Aldo, Matrone, Benedetta, Metra, Marco, Noonan, Katharine, Pina, Ileana, Prescott, Eva, Rosano, Giuseppe, Seferovic, Petar M, Sliwa, Karen, Stewart, Simon, Uijl, Alicia, Vaartjes, Ilonca, Vermeulen, Roel, Verschuren, W M, Volterrani, Maurizio, Von Haehling, Stephan, and Hoes, Arno

Abstract

The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present consensus document aims to provide practical evidence-based information to support the implementation of effective preventive measures. After reviewing the most common risk factors, an overview of the population attributable risks in different continents is presented, to identify potentially effective opportunities for prevention and to inform preventive strategies. Finally, potential interventions that have been proposed and have been shown to be effective in preventing HF are listed.

Published
2022
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248. The dynamics of mortality in follow-up time after an acute myocardial infarction, lower extremity arterial disease and ischemic stroke

Author

Grobbee Diederick E, van Dis Ineke, Vaartjes Ilonca, and Bots Michiel L

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Most studies providing data on survival in patients with atherosclerosis only address a single disease site: heart, brain or legs. Therefore, our objective was to determine risk of death after first hospital admission for atherosclerotic disease located at different sites. Methods A nationwide cohort of patients hospitalized for the first time for acute myocardial infarction (AMI), peripheral arterial disease of the lower extremities (PAD) or ischemic stroke was identified through linkage of national registers. The mortality rate in AMI patients was compared to mortality rate in ischemic stroke and PAD patients by estimating relative risks (with 95%CI). Cox's proportional hazard models were used to estimate sex differences in risk of death. Results Case fatality was high for ischemic stroke patients (men:21.0%, women:23.8%) and AMI patients (men:12.7%, women:20.9%) though low for PAD patients (men:2.4%, women:3.5%). The five-year risk of death was similar for male AMI compared to PAD patients (men: RR1.04; 95%CI 0.98-1.11). The risk of death for ischemic stroke patients remained the highest though the differences with AMI and PAD patients attenuated. Conclusions The dynamics of mortality over follow-up time clearly differ between atherosclerotic diseases, located at different vascular beds. The risk of death increases considerably over follow-up time for PAD patients, and 5 years after first hospital admission the differences in risks of death between AMI- and PAD patients and between AMI- and ischemic stroke patients have largely attenuated. Clinicians should be aware of these dynamics of mortality over follow-up time to provide optimal secondary prevention treatment.

Published
2010
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249. Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use

Author

Marees, Andries T, Hammerschlag, Anke R, Bastarache, Lisa, de Kluiver, Hilde, Vorspan, Florence, van den Brink, Wim, Smit, Dirk J, Denys, Damiaan, Gamazon, Eric R, Li-Gao, Ruifang, Breetvelt, Elemi J, de Groot, Mark C H, Galesloot, Tessel E, Vermeulen, Sita H, Poppelaars, Jan L, Souverein, Patrick C, Keeman, Renske, de Mutsert, Renée, Noordam, Raymond, Rosendaal, Frits R, Stringa, Najada, Mook-Kanamori, Dennis O, Vaartjes, Ilonca, Kiemeney, Lambertus A, den Heijer, Martin, van Schoor, Natasja M, Klungel, Olaf H, Maitland-Van der Zee, Anke H, Schmidt, Marjanka K, Polderman, Tinca J C, van der Leij, Andries R, Posthuma, Danielle, Derks, Eske M, Marees, Andries T, Hammerschlag, Anke R, Bastarache, Lisa, de Kluiver, Hilde, Vorspan, Florence, van den Brink, Wim, Smit, Dirk J, Denys, Damiaan, Gamazon, Eric R, Li-Gao, Ruifang, Breetvelt, Elemi J, de Groot, Mark C H, Galesloot, Tessel E, Vermeulen, Sita H, Poppelaars, Jan L, Souverein, Patrick C, Keeman, Renske, de Mutsert, Renée, Noordam, Raymond, Rosendaal, Frits R, Stringa, Najada, Mook-Kanamori, Dennis O, Vaartjes, Ilonca, Kiemeney, Lambertus A, den Heijer, Martin, van Schoor, Natasja M, Klungel, Olaf H, Maitland-Van der Zee, Anke H, Schmidt, Marjanka K, Polderman, Tinca J C, van der Leij, Andries R, Posthuma, Danielle, and Derks, Eske M

Abstract

BACKGROUND: Alcohol and tobacco use are heritable phenotypes. However, only a small number of common genetic variants have been identified, and common variants account for a modest proportion of the heritability. Therefore, this study aims to investigate the role of low-frequency and rare variants in alcohol and tobacco use.METHODS: We meta-analyzed ExomeChip association results from eight discovery cohorts and included 12,466 subjects and 7432 smokers in the analysis of alcohol consumption and tobacco use, respectively. The ExomeChip interrogates low-frequency and rare exonic variants, and in addition a small pool of common variants. We investigated top variants in an independent sample in which ICD-9 diagnoses of "alcoholism" (N = 25,508) and "tobacco use disorder" (N = 27,068) had been assessed. In addition to the single variant analysis, we performed gene-based, polygenic risk score (PRS), and pathway analyses.RESULTS: The meta-analysis did not yield exome-wide significant results. When we jointly analyzed our top results with the independent sample, no low-frequency or rare variants reached significance for alcohol consumption or tobacco use. However, two common variants that were present on the ExomeChip, rs16969968 (p = 2.39 × 10-7) and rs8034191 (p = 6.31 × 10-7) located in CHRNA5 and AGPHD1 at 15q25.1, showed evidence for association with tobacco use.DISCUSSION: Low-frequency and rare exonic variants with large effects do not play a major role in alcohol and tobacco use, nor does the aggregate effect of ExomeChip variants. However, our results confirmed the role of the CHRNA5-CHRNA3-CHRNB4 cluster of nicotinic acetylcholine receptor subunit genes in tobacco use.

Published
2018

250. Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations : Results from the Asia Pacific Cohort Studies Collaboration

Author

Peters, Sanne A.E., Wang, Xin, Lam, Tai Hing, Kim, Hyeon Chang, Ho, Suzanne, Ninomiya, Toshiharu, Knuiman, Matthew, Vaartjes, Ilonca, Bots, Michael L., Woodward, Mark, Peters, Sanne A.E., Wang, Xin, Lam, Tai Hing, Kim, Hyeon Chang, Ho, Suzanne, Ninomiya, Toshiharu, Knuiman, Matthew, Vaartjes, Ilonca, Bots, Michael L., and Woodward, Mark

Published
2018

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