36,438 results on '"University of Manitoba"'
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202. President's message and info re: COVID-19
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University of Manitoba Faculty Association and University of Manitoba Faculty Association
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This is a brief update on matters relating to the closure of campus and changes to the Winter and summer semester, and of specific interest to probationary (tenure track) members. UMFA and UM administration have arrived at an agreement on the important issue of the effect of COVID-19 on members holding tenure track appointments, particularly those whose tenure applications are due July 15, 2020.
203. Risk Assessment and Clinical Risk Management for Young Antisocial Children: The Forgotten Group
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Augimeri, Leena; Child Development Institute, Walsh, Margaret; Child Development Institute, Woods, Sarah; Child Development Institute, Jiang, Depeng; University of Manitoba, Augimeri, Leena; Child Development Institute, Walsh, Margaret; Child Development Institute, Woods, Sarah; Child Development Institute, and Jiang, Depeng; University of Manitoba
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Centre for Children Committing Offences (CCCO), at Child Development Institute (CDI) in Toronto, Canada, developed Early Assessment Risk Lists (EARL-20B for boys; EARL-21G for girls), for young children at-risk for future criminality. In this first EARL prospective longitudinal study, 573 boys and 294 girls who participated in SNAP®, a gender-specific evidencebased model for at-risk children (6-11 years), 8.2% of boys and 3.1% of girls had registered criminal offences at follow up (mean age 14.9 and 14.6 respectively). EARL Total, Family, Child, and Responsivity domain scores, including two gender-specific risk items and Overall Clinical Judgment predicted early onset of criminal activity. Findings suggest that gender-sensitive clinical risk assessment and management tools are important for effectively identifying and potentially reducing criminal outcomes
204. Archives & Special Collections Closed
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University of Manitoba and University of Manitoba
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As of Friday, March 20, 2020 the University of Manitoba Archives & Special Collections will be closed until further notice.
205. Archives & Special Collections Closed
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University of Manitoba and University of Manitoba
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As of Friday, March 20, 2020 the University of Manitoba Archives & Special Collections will be closed until further notice.
206. Waiting For Signalling Quality
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Hikmet, Gunay, University of Manitoba, Hikmet, Gunay, and University of Manitoba
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When a durable good of uncertain quality is introduced to the market, some consumers strategically delay their buying to the next period with the hope of learning the unknown quality. We analyze the monopolist's pricing and \waiting" strategies when consumers have strategic delay incentives. We show when the monopolist o®ers introductory low prices in pooling equilibria. We also ¯nd two types of separating equilibria: one where high type signals its quality by choosing a di®erent price than the low type in the ¯rst period, and another where the high-type monopolist announces the product in the ¯rst period and waits to sell only in the second period. Waiting creates a credible cost for signalling; hence, the monopolist uses it as a signalling device.
207. Waiting For Signalling Quality
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Hikmet, Gunay, University of Manitoba, Hikmet, Gunay, and University of Manitoba
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When a durable good of uncertain quality is introduced to the market, some consumers strategically delay their buying to the next period with the hope of learning the unknown quality. We analyze the monopolist's pricing and \waiting" strategies when consumers have strategic delay incentives. We show when the monopolist o®ers introductory low prices in pooling equilibria. We also ¯nd two types of separating equilibria: one where high type signals its quality by choosing a di®erent price than the low type in the ¯rst period, and another where the high-type monopolist announces the product in the ¯rst period and waits to sell only in the second period. Waiting creates a credible cost for signalling; hence, the monopolist uses it as a signalling device.
208. Trucking and Size and Weight Regulations in the Mid-Continent Corridor
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Montufar, Jeannette, University of Manitoba, Montufar, Jeannette, and University of Manitoba
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This thesis is an empirical analysis of trucking and truck size and weight (TS&W) regulations in the Mid-continent conidor. Based on this analysis, it compares and contrasts plausible near term TS&W policy options relating to this corridor., The approach of the research is to understand the corridor?s TS&W regulations, trucking activity, and commodity and trade flows; with a view to facilitating the comparing and contrasting of TS&W policy options. With this understanding, the thesis then compares and contrasts the TS&W policy options., The corridor is governed by a complex set of TS&W regulations emanating directly from the U.S. Federal Government, the nine corridor States, Mexico, Manitoba, and indirectly from other jurisdictions throughout North America. This regulatory environment includes important differences on limits concerning tire loads, axle loads, gross vehicle weights, Bridge Formula requirements, vehicle heights, vehicle widths, semitrailer lengths, vehicle combination lengths, and large truck conllgurations. These TS&W regulations have created a complex truck fleet with many different physical and operational characteristics. This fleet includes vehicles designed for ?go anywhere? trucking to many types of special vehicles with unique body types, axle arrangements, and tire arrangements designed to optimize operations for specific commodities, origin-destination pairs, and truck routings., The total activity in the corridor is dominated by intrajurisdictional movements. However, while the corridor is often characterized as a north-south entity, much of its transportation activity in fact runs east-west to and from or through the corridor States. Also, the amount of interstate trucking that occurs within the corridor is minimal and very little north-south, interjurisdictional activity takes place to and from the corridor.sections of the corridor involve low to medium truck volumes, while some involve very high volumes. The lowest truck volumes along the corridor occur at its ends--south of the Manitoba-U.S. border, between Minneapolis and Duluth, between Laredo and Cotulla--and in its middle on the east side of Wichita, Kansas., Much of the trucking in this corridor takes place well within the boundary conditions established by the TS&W regulations governing trucking in the corridor. Therefore, relaxation of these regulations can only be of real consequence in the near to medium term to mainly selected aspects of the total trucking activity., Many of the detailed regulatory differences that exist today relating to trucking in the Mid-continent corridor cannot be justified with any technical argument. There is good reason to pursue the harmonization and rationalization of TS&W regulatory differences of little or no technical significance to facilitate safer and more efficient trucking in the corridor.
209. Early Palliative Care on Quality of Life of Patients With Advanced Pancreas Cancer
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CancerCare Manitoba, Celgene, and Christina Kim, Medical Oncologist, CancerCare Manitoba; Assistant Professor, University of Manitoba
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- 2022
210. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19
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Goligher, Ewan C, Bradbury, Charlotte A, McVerry, Bryan J, Lawler, Patrick R, Berger, Jeffrey S, Gong, Michelle N, Carrier, Marc, Reynolds, Harmony R, Kumar, Anand, Turgeon, Alexis F, Kornblith, Lucy Z, Kahn, Susan R, Marshall, John C, Kim, Keri S, Houston, Brett L, Derde, Lennie PG, Cushman, Mary, Tritschler, Tobias, Angus, Derek C, Godoy, Lucas C, McQuilten, Zoe, Kirwan, Bridget-Anne, Farkouh, Michael E, Brooks, Maria M, Lewis, Roger J, Berry, Lindsay R, Lorenzi, Elizabeth, Gordon, Anthony C, Berry, Scott M, McArthur, Colin J, Neal, Matthew D, Hochman, Judith S, Webb, Steven A, Zarychanski, Ryan, Ahuja, Tania, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Kreuziger, Lisa Baumann, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Contreras, Aira, Costantini, Todd W, de Brouwer, Sophie, Detry, Michelle A, Duggal, Abhijit, Dzavik, Vladimir, Effron, Mark B, Eng, Heather F, Escobedo, Jorge, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Froess, Joshua D, Fu, Zhuxuan, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, Girard, Timothy D, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Haniffa, Rashan, Hegde, Sheila M, Hendrickson, Carolyn M, Higgins, Alisa M, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Huang, David T, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei, King, Andrew J, Kornblith, Aaron E, Kutcher, Matthew E, Laffan, Michael A, Lamontagne, Francois, Le Gal, Gregoire, Leeper, Christine M, Leifer, Eric S, Lim, George, Lima, Felipe Gallego, Linstrum, Kelsey, Litton, Edward, Lopez-Sendon, Jose, Lother, Sylvain A, Marten, Nicole, Marinez, Andrea Saud, Martinez, Mary, Garcia, Eduardo Mateos, Mavromichalis, Stavroula, McAuley, Daniel F, McDonald, Emily G, McGlothlin, Anna, McGuinness, Shay P, Middeldorp, Saskia, Montgomery, Stephanie K, Mouncey, Paul R, Murthy, Srinivas, Nair, Girish B, Nair, Rahul, Nichol, Alistair D, Nicolau, Jose C, Nunez-Garcia, Brenda, Park, John J, Park, Pauline K, Parke, Rachael L, Parker, Jane C, Parnia, Sam, Paul, Jonathan D, Pompilio, Mauricio, Quigley, John G, Rosenson, Robert S, Rost, Natalia S, Rowan, Kathryn, Santos, Fernanda O, Santos, Marlene, Santos, Mayler O, Satterwhite, Lewis, Saunders, Christina T, Schreiber, Jake, Schutgens, Roger EG, Seymour, Christopher W, Siegal, Deborah M, Silva, Delcio G, Singhal, Aneesh B, Slutsky, Arthur S, Solvason, Dayna, Turner, Anne M, Van Bentum-Puijk, Wilma, van de Veerdonk, Frank L, van Diepen, Sean, Vazquez-Grande, Gloria, Wahid, Lana, Wareham, Vanessa, Widmer, R Jay, Wilson, Jennifer G, Yuriditsky, Eugene, Zhong, Yongqi, Investigators, REMAP-CAP, Investigators, ACTIV-4a, Investigators, ATTACC, NIHR, National Institute for Health Research, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Institutes of Health, NIH: 1OT2HL156812-01, AR7-162822, OTA-20-011, RP-2015-06-18, National Heart, Lung, and Blood Institute, NHLBI, Amgen, CancerCare Manitoba Foundation, CCMF, University of Manitoba, UM, Health Research Board, HRB: CTN 2014-012, Canadian Institutes of Health Research, CIHR: 158584, 447335, COVID-19, National Institute for Health Research, NIHR, European Commission, EC: 602525, FP7-HEALTH-2013-INNOVATION, National Health and Medical Research Council, NHMRC: APP1101719, APP1116530, Health Research Council of New Zealand, HRC: 16/631, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Université Pierre et Marie Curie, UPMC, Horizon 2020: 101003589, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, REMAP-CAP was supported by the European Union through FP7-HEALTH-2013-INNOVATION: the Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE) consortium (grant 602525) and the Horizon 2020 research and innovation program: the Rapid European Covid-19 Emergency Research response (RECOVER) consortium (grant 101003589) and by grants from the Australian National Health and Medical Research Council (APP1101719 and APP1116530), the Health Research Council of New Zealand (16/631), the Canadian Institutes of Health Research (Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant 158584 and COVID-19 Rapid Research Operating Grant 447335), the U.K. National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the French Ministry of Health (PHRC-20-0147), the Minderoo Foundation, Amgen, Eisai, the Global Coalition for Adaptive Research, and the Wellcome Trust Innovations Project (215522). The ATTACC platform was supported by grants from the Canadian Institutes of Health Research, LifeArc, Thistledown Foundation, Research Manitoba, CancerCare Manitoba Foundation, Victoria General Hospital Foundation, Ontario Ministry of Health, and the Peter Munk Cardiac Centre. The ACTIV-4a platform was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) and administered through OTA-20-011 and was supported in part by NIH agreement 1OT2HL156812-01. Dr. Goligher is the recipient of an Early Career Investigator award from the Canadian Institutes of Health Research (grant AR7-162822). Dr. Gordon is funded by an NIHR Research Professorship (RP-2015-06-18). Dr. Turgeon is funded by a Canada Research Chair-Tier 2. Dr. Zarychanski is the recipient of the Lyonel G. Israels Research Chair in Hematology (University of Manitoba)., Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, Investigators, REMAP-CAP, Investigators, ACTIV-4a, Investigators, ATTACC, REMAP-CAP Investigators, ACTIV-4a Investigators, and ATTACC Investigators
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Male ,covid-19, anticoagulation ,adaptive platform trial ,[SDV]Life Sciences [q-bio] ,Critical Illness ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Hemorrhage ,030204 cardiovascular system & hematology ,heparin ,COVID-19/drug therapy ,03 medical and health sciences ,0302 clinical medicine ,Medicine, General & Internal ,Hemorrhage/chemically induced ,General & Internal Medicine ,Odds Ratio ,thrombosis, covid-19 ,Humans ,030212 general & internal medicine ,Hospital Mortality ,Treatment Failure ,Heparin/administration & dosage ,anticoagulation ,11 Medical and Health Sciences ,Aged ,Anticoagulants/administration & dosage ,Science & Technology ,Thrombosis/prevention & control ,Heparin ,low molecular weight heparin ,Anticoagulants ,COVID-19 ,Thrombosis ,General Medicine ,Middle Aged ,Respiration, Artificial ,3. Good health ,COVID-19 Drug Treatment ,critical care ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Logistic Models ,ACTIV-4a Investigators ,Female ,Human medicine ,ATTACC Investigators ,REMAP-CAP Investigators ,Covid-19 ,Life Sciences & Biomedicine - Abstract
BACKGROUNDThrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.METHODSIn an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined regimen of either therapeutic-dose anticoagulation with heparin or pharmacologic thromboprophylaxis in accordance with local usual care. The primary outcome was organ support–free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of −1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge.RESULTSThe trial was stopped when the prespecified criterion for futility was met for therapeutic-dose anticoagulation. Data on the primary outcome were available for 1098 patients (534 assigned to therapeutic-dose anticoagulation and 564 assigned to usual-care thromboprophylaxis). The median value for organ support–free days was 1 (interquartile range, −1 to 16) among the patients assigned to therapeutic-dose anticoagulation and was 4 (interquartile range, −1 to 16) among the patients assigned to usual-care thromboprophylaxis (adjusted proportional odds ratio, 0.83; 95% credible interval, 0.67 to 1.03; posterior probability of futility [defined as an odds ratio CONCLUSIONSIn critically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin did not result in a greater probability of survival to hospital discharge or a greater number of days free of cardiovascular or respiratory organ support than did usual-care pharmacologic thromboprophylaxis. (REMAP-CAP, ACTIV-4a, and ATTACC ClinicalTrials.gov numbers, NCT02735707. opens in new tab, NCT04505774. opens in new tab, NCT04359277. opens in new tab, and NCT04372589. opens in new tab.)
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- 2021
211. Sci-Thur AM: YIS – 05: Prediction of lung tumor motion using a generalized neural network optimized from the average prediction outcome of a group of patients
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Pistorius, Stephen [University of Manitoba/ CancerCare Manitoba, University of Manitoba, University of Manitoba, University of Manitoba / CancerCare Manitoba (Canada)]
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- 2016
- Full Text
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212. Phone Call Follow-up After Crisis Centre Presentation With Suicidal Ideation and Behaviours.
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Primary Supervisor: Dr. James Bolton MD FRCPC and Laura Sutherland, PGY1 Psychiatry (University of Manitoba)
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- 2020
213. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial
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Writing Committee for the REMAP-CAP Investigators, Estcourt, Lise J, Turgeon, Alexis F, McQuilten, Zoe K, McVerry, Bryan J, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Arnold, Donald M, Beane, Abigail, Bégin, Philippe, van Bentum-Puijk, Wilma, Berry, Lindsay R, Bhimani, Zahra, Birchall, Janet E, Bonten, Marc JM, Bradbury, Charlotte A, Brunkhorst, Frank M, Buxton, Meredith, Callum, Jeannie L, Chassé, Michaël, Cheng, Allen C, Cove, Matthew E, Daly, James, Derde, Lennie, Detry, Michelle A, De Jong, Menno, Evans, Amy, Fergusson, Dean A, Fish, Matthew, Fitzgerald, Mark, Foley, Claire, Goossens, Herman, Gordon, Anthony C, Gosbell, Iain B, Green, Cameron, Haniffa, Rashan, Harvala, Heli, Higgins, Alisa M, Hills, Thomas E, Hoad, Veronica C, Horvat, Christopher, Huang, David T, Hudson, Cara L, Ichihara, Nao, Laing, Emma, Lamikanra, Abigail A, Lamontagne, François, Lawler, Patrick R, Linstrum, Kelsey, Litton, Edward, Lorenzi, Elizabeth, MacLennan, Sheila, Marshall, John, McAuley, Daniel F, McDyer, John F, McGlothlin, Anna, McGuinness, Shay, Miflin, Gail, Montgomery, Stephanie, Mouncey, Paul R, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane C, Priddee, Nicole, Purcell, Damian FJ, Reyes, Luis F, Richardson, Peter, Robitaille, Nancy, Rowan, Kathryn M, Rynne, Jennifer, Saito, Hiroki, Santos, Marlene, Saunders, Christina T, Serpa Neto, Ary, Seymour, Christopher W, Silversides, Jon A, Tinmouth, Alan A, Triulzi, Darrell J, Turner, Anne M, van de Veerdonk, Frank, Walsh, Timothy S, Wood, Erica M, Berry, Scott, Lewis, Roger J, Menon, David K, McArthur, Colin, Zarychanski, Ryan, Angus, Derek C, Webb, Steve A, Roberts, David J, Shankar-Hari, Manu, Menon, David [0000-0002-3228-9692], Apollo - University of Cambridge Repository, Investigators, Writing Committee for the REMAP-CAP, Writing Comm REMAP-CAP Investigators, Hôpital Raymond Poincaré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Institutes of Health, NIH, National Institute of Child Health and Human Development, NICHD, Pittsburgh Foundation, Breast Cancer Research Foundation, BCRF, Bristol-Myers Squibb, BMS, GlaxoSmithKline, GSK, Medtronic, Baxter International, Manitoba Medical Service Foundation, MMSF, CancerCare Manitoba Foundation, CCMF, Wellcome Trust, WT, University of Manitoba, UM, Health Research Board, HRB: PHRC-20-0147, National Blood Authority, NBA, Llywodraeth Cymru, Translational Breast Cancer Research Consortium, TBCRC, Canadian Institutes of Health Research, IRSC: 158584, CTN 2014-012, Medical Research Council, MRC, National Institute for Health Research, NIHR, Department of Health and Social Care, DH, European Commission, EC: APP194811, National Heart and Lung Institute, NHLI, National Health and Medical Research Council, NHMRC: 2015-06-18, 2016-16-011, APP1101719, APP2002132, Health Research Council of New Zealand, HRC: 16/631, 447335, Monash University, MU, Ministère des Affaires Sociales et de la Santé: 215522, Seventh Framework Programme, FP7, Université Pierre et Marie Curie, UPMC, Innovate UK, Horizon 2020, Pharmaceuticals Bayer, Minderoo Foundation, Dr Fitzgerald reported receiving grants from the PREPARE Network and the European Commission. Dr Gordon reported receiving grants from the National Institute for Health Research and receiving personal fees from 30 Respiratory, GlaxoSmithKline, and Bristol Myers Squibb. Dr Gosbell reported receiving grants from the Australian Red Cross Lifeblood, which is funded by the Australian government. Dr Haniffa reported receiving grants from the Wellcome Trust Innovations Project, the Minderoo Foundation, and the UK Research and Innovation African Critical Care Registry Network. Dr Higgins reported receiving grants from the National Health and Medical Research Council, the Minderoo Foundation, and the National Blood Authority. Dr Hills reported receiving grants from the Health Research Council of New Zealand. Dr Hoad reported receiving grants from the Australian Red Cross Lifeblood, which is funded by the Australian government. Dr Horvat reported receiving grants from the National Institute of Child Health and Human Development. Dr Huang reported receiving grants from the Breast Cancer Research Foundation. Dr Lamontagne reported receiving grants from the Canadian Institutes of Health Research. Dr Lawler reported receiving consulting fees from Novartis, Coronna LLC, and Brigham and Women’s Hospital, receiving royalties from McGraw-Hill Publishing, and receiving grants from the Canadian Institutes of Health Research, the LifeArc Foundation, the National Institutes of Health, the Peter Munk Cardiac Centre, the Ted Rogers Centre for Heart Research, the Thistledown Foundation, and the province of Ontario. Dr Lorenzi reported receiving personal fees from Berry Consultants. Dr Marshall reported receiving personal fees from AM-Pharma (data and safety monitoring board chair) and Critical Care Medicine (associate editor). Dr McAuley reported receiving personal fees from Bayer, GlaxoSmithKline, Boehringer Ingelheim, Novartis, Eli Lilly, Vir Biotechnology, Faron Pharmaceuticals, and Sobi, receiving grants from the National Institute for Health Research, Wellcome Trust, Innovate UK, the Medical Research Council, and the Northern Ireland Health and Social Care Research and Development Division, and holding a patent for an anti-inflammatory treatment that was issued to Queen’s University Belfast. Dr McGlothlin reported receiving grants from the PREPARE Network, the European Commission, and the Global Coalition for Adapative Research. Mr Mouncey reported receiving grants from the European Union, the PREPARE Network, the National Institute for Health Research, and European Union Horizon 2020. Dr Nichol reported receiving grants from the Health Research Board of Ireland and Baxter and receiving personal fees from AM-Pharma. Dr Parke reported receiving grants from Fisher and Paykel Healthcare Ltd. Ms Parker reported receiving grants from Monash University. Mr Richardson reported receiving funding from the Welsh government. Dr Rowan reported receiving grants from the European Commission and the National Institute for Health Research. Dr Saunders reported receiving grants from the PREPARE Network, the European Commission, and the Global Coalition for Adapative Research. Dr Serpa Neto reported receiving personal fees from Drager and Endpoint Health. Dr Tinmouth reported receiving grants and personal fees from the Canadian Blood Services. Ms Turner reported receiving grants from the Health Research Council of New Zealand. Dr van de Veerdonk reported receiving personal fees from Gilead, Sobi, and GlaxoSmithKline. Dr Wood reported receiving grants from the Australian Medical Research Future Fund. Dr S. Berry reported being an employee of Berry Consultants with an ownership role. Dr Lewis reported being an employee of Berry Consultants. Dr Menon reported receiving grants from the National Institute for Health Research. Dr McArthur reported receiving grants from the Health Research Council of New Zealand. Dr Zarychanski reported receiving grants from the Canadian Institutes of Health Research, the University of Manitoba, LifeArc, the Thistledown Foundation, Research Manitoba, the CancerCare Manitoba Foundation, the Victoria General Hospital Foundation, the Peter Munk Cardiac Centre, and the Manitoba Medical Services Foundation. Dr Webb reported receiving grants from the National Health and Medical Research Council and the Minderoo Foundation. Dr Shankar-Hari reported receiving grants from the National Institute for Clinical Research. No other disclosures were reported., nonprofit sponsors: Monash University, Melbourne, Australia (Australasian sponsor), Utrecht Medical Center, Utrecht, the Netherlands (European sponsor), St Michael’s Hospital, Toronto, Ontario, Canada (Canadian sponsor), and the Global Coalition for Adaptive Research, San Francisco, California (US sponsor). This study was additionally funded by grant 602525 FP7-health-2013-innovation-1 from the European Union Platform for European Preparedness Against Reemerging Epidemics, grants APP1101719 and APP1116530 from the Australian National Health and Medical Research Council, grant APP2002132 from the Australian Medical Research Future Fund, grant 16/631 from the New Zealand Health Research Council, grant 447335 from the Canadian Institutes of Health Research COVID-19 Rapid Research, grant 158584 from the Canadian Institutes of Health Research Strategy for Patient-Oriented Research Innovative Clinical Trials Program, grant CTN 2014-012 from the Health Research Board of Ireland, grant PHRC-20-0147 from the French Ministry of Health, and grant 215522 from the Wellcome Trust Innovations Project and funding from the National Institute for Health Research, the Department of Health and Social Care, the EU Programme Emergency Support Instrument, the NHS Blood and Transplant Research and Development Programme, the National Institute for Health Research, the National Institute for Health Research Imperial Biomedical Research Centre, the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the Pittsburgh Foundation, and the Minderoo Foundation. The Australian government funds the Australian Red Cross Lifeblood for the provision of blood products and services. The collection of plasma in the United Kingdom was funded by European Union SoHo grants from the Department of Health and Social Care. Dr Turgeon is the Canada Research Chair in Critical Care Neurology and Trauma. Dr McQuilten is supported by emerging leader fellowship APP194811 from the National Health and Medical Research Council. Dr Gordon is funded by research professorship 2015-06-18 from the National Institute for Health Research. Dr Shankar-Hari is funded by clinician scientist fellowship 2016-16-011 from the National Institute for Health Research., In Canada, the trial has been funded by the Canadian Institute of Health Research, Strategy for Patient-Oriented Research (CIHR-SPOR) Innovative Clinical Trials Program Grant (no. 158584) for CAD $1,497,200, for the recruitment of 300 patients., The Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE) consortium is funded by the European Union (FP7-HEALTH-2013-INNOVATION-1, grant number 602525). Within the PREPARE consortium, the trial has funding for the recruitment of approximately 4000 patients., REMAP-CAP was supported in the Netherlands by the Research Collaboration Critical Care the Netherlands (RCC-Net)., Funding sources for the REMAP-CAP trial are specified in the core protocol documents. This domain has received domain-specific funding from the Australian Medical Research Future Fund (MRFF)., reported receiving grants from the National Institute for Health Research and European Union Horizon 2020. Dr Turgeon reported receiving grants from the Canadian Institutes of Health Research. Dr McQuilten reported receiving grants from the Australian Medical Research Future Fund. Dr McVerry reported receiving grants from the Pittsburgh Foundation, the Translational Breast Cancer Research Consortium, UPMC Learning While Doing Program, National Heart, Lung, and Blood Institute, and Bayer Pharmaceuticals and receiving personal fees from Boehringer Ingelheim. Dr Annane reported receiving grants from the French Ministry of Health and Solidarity. Dr Arnold reported receiving grants from the Canadian Institutes of Health Research. Ms Beane reported receiving grants and salary support from Wellcome Trust. Ms Bentum-Puijk reported receiving grants from the European Commission and the European Union. Dr L. Berry reported receiving grants from Berry Consultants. Dr Bradbury reported receiving personal fees from Lilly, Bristol Myers Squibb, Pfizer, Bayer, Amgen, Novartis, Janssen, Portola Advisors, and Ablynx. Dr Buxton reported receiving personal fees from the Breast Cancer Research Foundation, Amgen, and Eisai. Dr Callum reported receiving grants from the Canadian Blood Services and Octapharma. Dr Cove reported receiving grants from National University Health System, receiving consulting fees from Medtronic and Baxter, and holding a US patent for removal of carbon dioxide via dialysis. Dr Daly reported receiving grants from the Australian Red Cross Lifeblood, which is funded by the Australian government. Dr Derde reported receiving grants from University Medical Center Utrecht, being a member of the COVID-19 guideline committee of the Surviving Sepsis Campaign/ European Society of Intensive Care Medicine and European Society of Intensive Care Medicine COVID-19 taskforce, and serving as chair of the Dutch intensivists taskforce acute infectious threats. Dr Detry reported receiving grants from the European Union Platform for European Preparedness Against Reemerging Epidemics (PREPARE) consortium, the Australian National Health and Medical Research Council, the Health Research Council of New Zealand, and the UPMC Learning While Doing Program. Dr De Jong reported receiving personal fees from Roche Scientific, Shionogi Scientific, and Janssen., The current regions are: x Europe, with funding from a European Union FP7 grant (FP7-HEALTH-2013-INNOVATION-1, grant number 602525), to support the enrollment of 4000 participants. This funding terminates in 2021. x Australia and New Zealand. In Australia the project has received funding from a NHMRC Project Grant (APP1101719), to support the enrollment of 2000 participants. This funding terminates in December 2021, although some extension may be feasible. In New Zealand the project has received funding from a HRC Programme Grant (16/631), to support the enrollment of 800 participants. This funding terminates in November 2021. x Canada. In Canada the project has received funding for a CIHR grant (158584), to support the enrollment of 300 participants. This funding terminates in 2022. x United States. In the US, funding has been received from UPMC health system for recruitment internally at all UPMC hospitals (>40) and to support a US regional coordinating center. Philanthropic support is being provided through GCAR. Additional funds are being pursued., The REMAP-CAP platform is supported by the Australian and New Zealand Intensive Care Society Clinical Trials Group, the Canadian Critical Care Trials Group, the Irish Critical Care, European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014), NIHR, National Institute for Health Research, Medical Microbiology and Infection Prevention, AII - Infectious diseases, and Intensive Care Medicine
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Male ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,030204 cardiovascular system & hematology ,Logistic regression ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,Critical Illness/therapy ,Vasoconstrictor Agents ,030212 general & internal medicine ,Hospital Mortality ,Treatment Failure ,11 Medical and Health Sciences ,Original Investigation ,Mortality rate ,General Medicine ,Middle Aged ,Intensive care unit ,Writing Committee for the REMAP-CAP Investigators ,3. Good health ,Female ,Life Sciences & Biomedicine ,COVID-19/therapy ,Adult ,medicine.medical_specialty ,Randomization ,Respiration, Artificial/statistics & numerical data ,Critical Illness ,ABO Blood-Group System ,03 medical and health sciences ,Medicine, General & Internal ,Internal medicine ,General & Internal Medicine ,medicine ,Humans ,Adverse effect ,COVID-19 Serotherapy ,Aged ,Mechanical ventilation ,Science & Technology ,business.industry ,Immunization, Passive ,Vasoconstrictor Agents/therapeutic use ,COVID-19 ,Odds ratio ,Length of Stay ,Respiration, Artificial ,Logistic Models ,Human medicine ,business - Abstract
Importance The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.Objective To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.Design, Setting, and Participants The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and January 18, 2021, within at least 1 domain; 2011 critically ill adults were randomized to open-label interventions in the immunoglobulin domain at 129 sites in 4 countries. Follow-up ended on April 19, 2021.Interventions The immunoglobulin domain randomized participants to receive 2 units of high-titer, ABO-compatible convalescent plasma (total volume of 550 mL ± 150 mL) within 48 hours of randomization (n = 1084) or no convalescent plasma (n = 916).Main Outcomes and Measures The primary ordinal end point was organ support–free days (days alive and free of intensive care unit–based organ support) up to day 21 (range, −1 to 21 days; patients who died were assigned –1 day). The primary analysis was an adjusted bayesian cumulative logistic model. Superiority was defined as the posterior probability of an odds ratio (OR) greater than 1 (threshold for trial conclusion of superiority >99%). Futility was defined as the posterior probability of an OR less than 1.2 (threshold for trial conclusion of futility >95%). An OR greater than 1 represented improved survival, more organ support–free days, or both. The prespecified secondary outcomes included in-hospital survival; 28-day survival; 90-day survival; respiratory support–free days; cardiovascular support–free days; progression to invasive mechanical ventilation, extracorporeal mechanical oxygenation, or death; intensive care unit length of stay; hospital length of stay; World Health Organization ordinal scale score at day 14; venous thromboembolic events at 90 days; and serious adverse events.Results Among the 2011 participants who were randomized (median age, 61 [IQR, 52 to 70] years and 645/1998 [32.3%] women), 1990 (99%) completed the trial. The convalescent plasma intervention was stopped after the prespecified criterion for futility was met. The median number of organ support–free days was 0 (IQR, –1 to 16) in the convalescent plasma group and 3 (IQR, –1 to 16) in the no convalescent plasma group. The in-hospital mortality rate was 37.3% (401/1075) for the convalescent plasma group and 38.4% (347/904) for the no convalescent plasma group and the median number of days alive and free of organ support was 14 (IQR, 3 to 18) and 14 (IQR, 7 to 18), respectively. The median-adjusted OR was 0.97 (95% credible interval, 0.83 to 1.15) and the posterior probability of futility (OR Conclusions and Relevance Among critically ill adults with confirmed COVID-19, treatment with 2 units of high-titer, ABO-compatible convalescent plasma had a low likelihood of providing improvement in the number of organ support–free days.Trial Registration ClinicalTrials.gov Identifier: NCT02735707
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214. HOMOTOPIC NERVE APPROXIMATION BOUNDARY IN A PLANAR WHITEHEAD CW SPACE. FREE GROUP PRESENTATIONS
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Peters, J, University of Manitoba, University of Manitoba [Winnipeg], and Peters, James
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[MATH.MATH-AT]Mathematics [math]/Algebraic Topology [math.AT] ,[MATH.MATH-AT] Mathematics [math]/Algebraic Topology [math.AT] - Abstract
This paper introduces rough homotopic nerve complexes in a planar Whitehead CW space and their Rotman free group presentations. A rough homotopic nerve results is a collection of path-connected homotopic 1-cycles whose approximation boundary is nonempty. A homotopic 1-cycle has the structure of a 1-cycle in a CW space in which cycle edges are replaced by homotopic maps. Let △ be the members v of V (collection vertexes in path-connected 1-cycles), each written as a linear combination of the basis elements of a basis B ⊆ V. A presentation of G(V, +) is a mapping B × △ → G({ v ∈ V := ∑ k∈Z g∈B kg } , +). The main results in this paper are (1) Every rough homotopic vortex nerve has a free group presentation, (2) For a rough vortex nerve that consists of a finite collection of closed, convex sets in Euclidean space, the nerve and union of sets in the nerve have the same homotopy type and (3) Every Betti number has a corresponding rough set., Cet article présente des complexes nerveux homotopes rugueux dans un espace planaire de Whitehead CW et leurs présentations de groupe libre Rotman. Un nerf homotope rugueux résulte en une collection de 1-cycles homotopes reliés au chemin dont la limite d'approximation est non vide. Un cycle homotope a la structure d'un cycle 1 dans un espace CW dans lequel les arêtes de cycle sont remplacées par des applications homotopes. Soit △ les membres v de V (sommets de collection dans des 1-cycles connectés par chemin), chacun écrit comme une combinaison linéaire des éléments de base d'une base B ⊆ V. Une présentation de G(V, +) est une application B × △ → G({ v V := ∑ k∈Z g∈B kg } , +). Les principaux résultats de cet article sont (1) Chaque nerf vortex homotope rugueux a une présentation de groupe libre, (2) Pour un nerf vortex rugueux qui consiste en une collection finie d'ensembles fermés et convexes dans l'espace euclidien, le nerf et l'union des ensembles dans le nerf ont le même type d'homotopie et (3) Chaque nombre de Betti a un ensemble approximatif correspondant.
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215. Prime-like Elements and Semi-direct Products in Commutative Banach Algebras
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Thomas, Marc P.
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216. TEMPORAL PROXIMITIES. SELF-SIMILAR, TEMPORALLY CLOSE SHAPES
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Shangol, Muhammad, Peters, James, University of Manitoba, University of Manitoba [Winnipeg], and Peters, James
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[MATH] Mathematics [math] ,[MATH]Mathematics [math] - Abstract
This article introduces temporal proximity spaces as a framework to observe surface shapes as well as geometric shapes that change over time. A surface shape has a boundary and a non-empty interior, which is approximated by a geometric shape that lies within the boundary of a surface shape recorded in a video frame. Temporally close shapes (briefly, δ ∆t shapes) persist over the some temporal interval. Those surface shapes that appear withing the same video frame are strongly self-similar as well as temporally close. The rate of change of self-similar shapes shE, shE ′ is represented by ∇(shE), ∇(shE ′) pairs. Temporally close shapes that appear during the same temporal interval may or may not be spatially or descriptively close to each other. Persistent as well as spatially close shapes share belong to the same era and also overlap along their boundaries or withing their interiors. Overlapping appearances of shapes such as vortexes occur within temporal CW (Closurefinite Weak) spaces (briefly, tCW spaces), which are an extension of the CW spaces introduced by J.H.C. Whitehead during the 1940s. Because of their simplicity, tCW space provide a workable setting for the study of δ ∆t surface as well as geometric shapes in sequences of video frames. Contents 14 Appendix D.Čech Proximity Spaces 15 References 16
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217. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19
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Lawler, Patrick R, Golighe, Ewan C, Berge, Jeffrey S, Neal, Matthew D, McVerry, Bryan J, Nicolau, Jose C, Gong, Michelle N, Carrier, Marc, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Escobedo, Jorge, Huang, David T, Bradbury, Charlotte A, Houston, Brett L, Kornblith, Lucy Z, Kumar, Anand, Kah, Susan RN, Cushman, Mary, McQuilten, Zoe, Slutsky, Arthur S, Kim, Keri S, Gordon, Anthony C, Kirwan, Bridget-Anne, Brooks, Maria M, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Angus, Derek C, McArthur, Colin J, Webb, Steven A, Farkouh, Michael E, Hochman, Judith S, Zarychanski, Ryan, Aday, Aaron W, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Kreuziger, Lisa Baumann, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadzw, Tamta, Coiffard, Benjamin, Costantini, Todd W, de Brouwer, Sophie, Derde, Lennie PG, Detry, Michelle A, Duggal, Abhijit, Dzavik, Vladimir, Effron, Mark B, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, Garcia-Madrona, Sebastian, Girard, Timothy D, Godoy, Lucas C, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Hamburg, Naomi M, Haniffa, Rashan, Hanna, George, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Iyer, Vivek N, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei L, Kin, Andrew J, Knudson, M Margaret, Kornblith, Aaron E, Krishnan, Vidya, Kutcher, Matthew E, Laffan, Michael A, Lamontagne, Francois, Le Gal, Gregoire, Leeper, Christine M, Leifer, Eric S, Lim, George, Lima, Felipe Gallego, Linstrum, Kelsey, Litton, Edward, Lopez-Sendon, Jose, Moreno, Jose L Lopez-Sendon, Lother, Sylvain A, Malhotra, Saurabh, Marcos, Miguel, Marinez, Andrea Saud, Marshall, John C, Marten, Nicole, Matthay, Michael A, McAuley, Daniel F, McDonald, Emily G, McGlothlin, Anna, McGuinness, Shay P, Middeldorp, Saskia, Montgomery, Stephanie K, Moore, Steven C, Guerreor, Raquel Morillo, Mouncey, Paul R, Murthy, Srinivas, Nair, Girish B, Nair, Rahul, Nichol, Alistair D, Nunez-Garcia, Brenda, Pandey, Ambarish, Park, Pauline K, Parke, Rachael L, Parker, Jane C, Parnia, Sam, Paul, Jonathan D, Gonzalez, Yessica S Perez, Pompilio, Mauricio, Prekker, Matthew E, Quigley, John G, Rost, Natalia S, Rowan, Kathryn, Santos, Fernanda O, Santos, Marlene, Santos, Mayler Olombrada, Satterwhite, Lewis, Saunders, Christina T, Schutgens, Roger EG, Seymour, Christopher W, Siegal, Deborah M, Jr, Silva Delcio G, Shankar-Hari, Manu, Sheehan, John P, Singhal, Aneesh B, Solvaso, Dayna, Stanworth, Simon J, Tritschler, Tobias, Turner, Anne M, Van Bentum-Puijk, Wilma, van de Veerdonk, Frank L, van Diepen, Sean, Vazquez-Grande, Gloria, Wahid, Lana, Wareham, Vanessa, Wells, Bryan J, Widmer, R Jay, Wilson, Jennifer G, Yuriditsky, Eugene, Zampieri, Fernando G, Investigators, ATTACC, Investigators, ACTIV-4a, Investigators, REMAP-CAP, Investigators, ATTACC, Investigators, ACTIV-4a, Investigators, REMAP-CAP, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), 215522, AR7-162822, CS-2016-16-011, RP-2015-06-18, National Institutes of Health, NIH: 1OT2HL156812-01, OTA-20-011, UL1TR001445, National Heart, Lung, and Blood Institute, NHLBI, Breast Cancer Research Foundation, BCRF, National Center for Advancing Translational Sciences, NCATS, New York University, NYU, Medical Center, University of Pittsburgh, CancerCare Manitoba Foundation, CCMF, University of Manitoba, UM, Health Research Board, HRB: CTN 2014-012, Canadian Institutes of Health Research, CIHR, National Institute for Health Research, NIHR, European Commission, EC: 602525, FP7-HEALTH-2013-INNOVATION, National Health and Medical Research Council, NHMRC: APP1101719, APP1116530, Health Research Council of New Zealand, HRC: 158584, 16/631, 447335, Canada Research Chairs, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Horizon 2020: 101003589, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, The ATTACC platform was supported by grants from the Canadian Institutes of Health Research, LifeArc Foundation, Thistledown Foundation, Research Manitoba, Ontario Ministry of Health, Peter Munk Cardiac Centre, CancerCare Manitoba Foundation, and Victoria General Hospital Foundation. The ACTIV-4a platform was sponsored by the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH) (grant numbers, OTA-20-011 and 1OT2HL156812-01). The pilot program (PROTECT) was funded in part by a grant (UL1TR001445) from the New York University Clinical and Translational Science Award program, supported by the National Center for Advancing Translational Sciences of the NIH. The REMAP-CAP platform was supported by the European Union through FP7-HEALTH-2013-INNOVATION: the Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE) consortium (602525) and the Horizon 2020 research and innovation program: the Rapid European Covid-19 Emergency Research response (RECOVER) consortium (101003589), by the Australian National Health and Medical Research Council (APP1101719 and APP1116530), the Health Research Council of New Zealand (16/631), the Canadian Institutes of Health Research (Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant [158584] and Covid-19 Rapid Research Operating Grant [447335]), the U.K. National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the Learning While Doing Program at the University of Pittsburgh Medical Center, the Breast Cancer Research Foundation, the French Ministry of Health (PHRC-20-0147), the Minderoo Foundation, Am-gen, Eisai, the Global Coalition for Adaptive Research, and the Wellcome Trust Innovations Project (215522). Dr. Goligher is the recipient of an Early Career Investigator award from the Canadian Institutes of Health Research (grant AR7-162822). Dr. Gordon is supported by an NIHR Research Professorship (RP-2015-06-18), Dr. Shankar-Hari by an NIHR Clinician Scientist Fellowship (CS-2016-16-011), and Dr. Turgeon by a Canada Research Chair (Tier 2). Dr. Zarychanski is the recipient of the Lyonel G. Israels Research Chair in Hematology (University of Manitoba)., Listed are data that were included in the analysis involving patients with moderate severity of coronavirus disease 2019 (Covid-19). The denominators of patients in the anticoagulation group and the thrombophylaxis group are un-equal owing to response-adaptive randomization. The baseline characteristics of the patients according to d-dimer level are provided in Table S2 in the Supplementary Appendix. To convert the values for creatinine to micromoles per liter, multiply by 88.4. ULN denotes upper limit of the normal range. † Race or ethnic group was reported by the patients. ‡ The body-mass index is the weight in kilograms divided by the square of the height in meters. § Severe cardiovascular disease was defined as a baseline history of heart failure, myocardial infarction, coronary artery disease, peripheral arterial disease, or cerebrovascular disease (stroke or transient ischemic attack) in the ATTACC (Antithrombotic Therapy to Ameliorate Complications of Covid-19) and ACTIV-4a (A Multicenter, Adaptive, Ran-domized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic Strategies in Hospitalized Adults with COVID-19) platforms and as a baseline history of New York Heart Association class IV symptoms in the REMAP-CAP platform (Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia). ¶ Chronic respiratory disease was defined as a baseline history of asthma, chronic obstructive pulmonary disease, bron-chiectasis, interstitial lung disease, primary lung cancer, pulmonary hypertension, active tuberculosis, or the receipt of home oxygen therapy. ‖ Not listed are 74 patients who were coenrolled in the REMAP-CAP Antiplatelet Domain (39 in the anticoagulation group and 35 in the thromboprophylaxis group). ** In REMAP-CAP, levels of oxygen support (including no support) below the level of high-flow nasal cannula were not reported. †† The relative proportion of patients who were randomly assigned in each platform was imbalanced owing to imple-mentation of response-adaptive randomization in ATTACC on December 15, 2020. ‡‡ A total of 215 patients who were enrolled in the ATTACC platform were funded by the ACTIV4a platform by the National Heart, Lung, and Blood Institute. §§ Other participating countries were Mexico, Nepal, Australia, the Netherlands, and Spain., ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, Lawler, Patrick R [0000-0001-5155-5071], Neal, Matthew D [0000-0001-8931-6236], McVerry, Bryan J [0000-0002-1175-4874], Carrier, Marc [0000-0001-8296-2972], Escobedo, Jorge [0000-0003-1942-7402], Huang, David T [0000-0001-7649-1633], Bradbury, Charlotte A [0000-0001-5248-8165], Houston, Brett L [0000-0002-8776-4083], Kornblith, Lucy Z [0000-0002-1861-9691], Kim, Keri S [0000-0002-8480-4801], Gordon, Anthony C [0000-0002-0419-547X], Higgins, Alisa M [0000-0001-8295-7559], Aday, Aaron W [0000-0001-6243-3432], Aryal, Diptesh [0000-0002-1431-8293], Baumann Kreuziger, Lisa [0000-0002-1171-0548], Beane, Abi [0000-0001-7046-1580], Coiffard, Benjamin [0000-0002-8896-5346], Derde, Lennie PG [0000-0002-3577-5629], Detry, Michelle A [0000-0002-2794-1439], Estcourt, Lise J [0000-0003-4309-9162], Everett, Brendan M [0000-0002-6331-5224], Galen, Benjamin T [0000-0001-8172-258X], Girard, Timothy D [0000-0002-9833-4871], Godoy, Lucas C [0000-0001-6171-1269], Greenstein, Yonatan Y [0000-0002-5718-4408], Haniffa, Rashan [0000-0002-8288-449X], Hanna, George [0000-0001-8737-3843], Hegde, Sheila M [0000-0001-8157-8899], Hendrickson, Carolyn M [0000-0003-4662-2385], Hite, R Duncan [0000-0002-2625-8750], Hindenburg, Alexander A [0000-0002-1232-2168], Horvat, Christopher M [0000-0002-1593-2252], Jacobson, Jeffrey R [0000-0001-8929-994X], Kim, Yuri [0000-0001-5978-5779], King, Andrew J [0000-0002-9809-0563], Kutcher, Matthew E [0000-0003-4566-5359], Lima, Felipe Gallego [0000-0003-1204-5743], Lopez-Sendon Moreno, Jose L [0000-0001-9414-3990], Marcos, Miguel [0000-0003-1269-4487], McGlothlin, Anna [0000-0002-9079-6166], Mouncey, Paul R [0000-0002-8510-8517], Nunez-Garcia, Brenda [0000-0002-0355-4557], Parnia, Sam [0000-0002-6158-4404], Quigley, John G [0000-0003-3116-4545], Saunders, Christina T [0000-0003-4325-9568], Shankar-Hari, Manu [0000-0002-5338-2538], Sheehan, John P [0000-0002-4328-2613], Tritschler, Tobias [0000-0002-8775-0511], Yuriditsky, Eugene [0000-0003-2263-9297], Zampieri, Fernando G [0000-0001-9315-6386], Angus, Derek C [0000-0002-7026-5181], Apollo - University of Cambridge Repository, NIHR, and National Institute for Health Research
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Male ,covid-19, anticoagulation ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,030204 cardiovascular system & hematology ,heparin ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,Hemorrhage/chemically induced ,030212 general & internal medicine ,Hospital Mortality ,Heparin/administration & dosage ,anticoagulation ,11 Medical and Health Sciences ,Anticoagulants/administration & dosage ,Thrombosis/prevention & control ,low molecular weight heparin ,General Medicine ,Heparin ,Middle Aged ,Thrombosis ,Patient Discharge ,3. Good health ,Coagulation ,Original Article ,Female ,ATTACC Investigators ,medicine.symptom ,Covid-19 ,Life Sciences & Biomedicine ,medicine.drug ,Adult ,medicine.medical_specialty ,medicine.drug_class ,adaptive platform trial ,Low molecular weight heparin ,Inflammation ,Hemorrhage ,COVID-19/drug therapy ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,medicine ,Humans ,Intensive care medicine ,Survival analysis ,Aged ,Science & Technology ,business.industry ,SARS-CoV-2 ,Anticoagulants ,COVID-19 ,Odds ratio ,Heparin, Low-Molecular-Weight ,medicine.disease ,Survival Analysis ,COVID-19 Drug Treatment ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Heparin, Low-Molecular-Weight/therapeutic use ,ACTIV-4a Investigators ,Human medicine ,REMAP-CAP Investigators ,business - Abstract
BACKGROUNDThrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.METHODSIn this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care–level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis. The primary outcome was organ support–free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of −1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge. This outcome was evaluated with the use of a Bayesian statistical model for all patients and according to the baseline d-dimer level.RESULTSThe trial was stopped when prespecified criteria for the superiority of therapeutic-dose anticoagulation were met. Among 2219 patients in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support–free days as compared with usual-care thromboprophylaxis was 98.6% (adjusted odds ratio, 1.27; 95% credible interval, 1.03 to 1.58). The adjusted absolute between-group difference in survival until hospital discharge without organ support favoring therapeutic-dose anticoagulation was 4.0 percentage points (95% credible interval, 0.5 to 7.2). The final probability of the superiority of therapeutic-dose anticoagulation over usual-care thromboprophylaxis was 97.3% in the high d-dimer cohort, 92.9% in the low d-dimer cohort, and 97.3% in the unknown d-dimer cohort. Major bleeding occurred in 1.9% of the patients receiving therapeutic-dose anticoagulation and in 0.9% of those receiving thromboprophylaxis.CONCLUSIONSIn noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589. opens in new tab, NCT04505774. opens in new tab, NCT02735707. opens in new tab, and NCT04359277. opens in new tab.)
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218. The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data
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Eddy Moors, Uwe Eichelmann, Christian Brümmer, Stefano Minerbi, Barbara Marcolla, Gil Bohrer, Leonardo Montagnani, Üllar Rannik, Han Dolman, Janina Klatt, Samuli Launiainen, Elizabeth A. Walter-Shea, Nina Buchmann, Hank A. Margolis, Beniamino Gioli, Peter S. Curtis, Margaret S. Torn, Gabriela Posse, Luca Belelli Marchesini, Gianluca Filippa, Kenneth J. Davis, Leiming Zhang, Alexander Graf, Ray Leuning, Andrew Feitz, Simone Sabbatini, Harry McCaughey, Werner Eugster, Juha Pekka Tuovinen, Timothy J. Arkebauer, N. N. Vygodskaya, Adam J. Liska, Rosvel Bracho, Sebastian Wolf, Marc Aubinet, Jiří Dušek, Eugénie Paul-Limoges, Christof Ammann, Daniel Berveiller, Zoran Nesic, Giacomo Nicolini, Jaclyn Hatala Matthes, Russell L. Scott, David E. Reed, Frans-Jan W. Parmentier, Changliang Shao, Penélope Serrano-Ortiz, Yingnian Li, Jason Beringer, Marc Fischer, Deb Agarwal, Rasmus Fensholt, Russell K. Monson, Agnès de Grandcourt, Stefan K. Arndt, Timo Vesala, Uta Moderow, Joseph Verfaillie, Mika Aurela, Bev Law, Nina Hinko-Najera, Taro Nakai, Richard P. Phillips, Lindsay B. Hutley, Benjamin Loubet, Michele Tomassucci, Ayumi Kotani, Hans Peter Schmid, Raimundo Cosme de Oliveira, Anatoly A. Gitelson, Domenico Vitale, Regine Maier, Caitlin E. Moore, Xiaoqin Dai, Damien Bonal, John M. Frank, Yuelin Li, Christopher M. Gough, Shijie Han, Shirley A. Papuga, Edoardo Cremonese, Shawn Urbanski, Sébastien C. Biraud, Scott D. Miller, Mana Gharun, Annalea Lohila, Ian McHugh, Giovanni Manca, Bert Gielen, Wayne S. Meyer, Pierpaolo Duce, Bruce D. Cook, Carsten Gruening, Hiroki Ikawa, B.R. Reverter, Marian Pavelka, Andrew M. S. McMillan, Gang Dong, Isaac Chini, Kimberly A. Novick, Dalibor Janouš, Anne De Ligne, E. Beamesderfer, Marty Humphrey, Virginie Moreaux, Christian Wille, Markus Hehn, Hideki Kobayashi, Allen H. Goldstein, Walter C. Oechel, Richard Silberstein, Francisco Domingo, Francesco Mazzenga, Elise Pendall, Juha Hatakka, Lutz Merbold, Xingguo Han, Daniela Famulari, Carlo Trotta, Naama Raz-Yaseef, Dario Papale, Jean Marc Ourcival, Benoit Burban, Pavel Sedlák, Diego Polidori, Asko Noormets, Huimin Wang, Birger Ulf Hansen, Thomas Grünwald, Caroline Vincke, Robert M. Stevens, Carole Coursolle, D. P. Billesbach, Karl Schneider, Guoyi Zhou, Marcin Jackowicz-Korczynski, Paul V. Bolstad, Iris Feigenwinter, Shiping Chen, Julia Boike, Ivan Schroder, D. S. Christianson, Junhui Zhang, Pierre Cellier, Catharine van Ingen, Andrej Varlagin, A. Ribeca, Claudia Consalvo, Derek Eamus, Jason Brodeur, Alan G. Barr, Denis Loustau, Andreas Ibrom, Ankur R. Desai, Andrew E. Suyker, Efrén López-Blanco, Peter Cale, Nicola Arriga, William J. Massman, Abdelrahman Elbashandy, Yoshiko Kosugi, Pauline Buysse, Cove Sturtevant, T. A. Black, Housen Chu, David R. Bowling, Sabina Dore, Albin Hammerle, Tilden P. Meyers, M. Altaf Arain, Hatim Abdalla M. ElKhidir, Ignacio Goded, Roberto Zampedri, Alessio Collalti, Torsten Sachs, Tuomas Laurila, Cristina Poindexter, E. Canfora, Alexander Knohl, Donatella Spano, Silvano Fares, Scott R. Saleska, Michiel K. van der Molen, Suzanne M. Prober, Marryanna Lion, Steven C. Wofsy, Michael L. Goulden, Matthew Northwood, Antje Lucas-Moffat, Christine Moureaux, Jean-Marc Limousin, Sara H. Knox, Damiano Gianelle, Olaf Kolle, Jørgen E. Olesen, Mikhail Mastepanov, Bernard Heinesch, Christian Bernhofer, Peter D. Blanken, Hyojung Kwon, Georg Wohlfahrt, Peili Shi, Yann Nouvellon, Allison L. Dunn, Onil Bergeron, Mauro Cavagna, Heiko Prasse, Natalia Restrepo-Coupe, Yanhong Tang, Donatella Zona, Andrew S. Kowalski, Eric Dufrêne, Kim Pilegaard, Serena Marras, Yongtao He, Brent E. Ewers, Siyan Ma, Jean Marc Bonnefond, Jonas Ardö, Ko van Huissteden, Roser Matamala, Robin Weber, Nigel J. Tapper, Humberto Ribeiro da Rocha, Eva van Gorsel, Torbern Tagesson, Frederik Schrader, Frank Tiedemann, Myroslava Khomik, Torben R. Christensen, Jonathan E. Thom, James Cleverly, Víctor Resco de Dios, Ivan Shironya, Jeffrey P. Walker, You Wei Cheah, Ana López-Ballesteros, Georgia R. Koerber, J. William Munger, Shicheng Jiang, Johannes Lüers, Bruno De Cinti, Gilberto Pastorello, David R. Cook, Werner L. Kutsch, Paul Di Tommasi, Nicolas Delpierre, Peter Isaac, Carlos Marcelo Di Bella, Jiquan Chen, Craig Macfarlane, Dennis D. Baldocchi, William Woodgate, Riccardo Valentini, Marilyn Roland, Ladislav Šigut, Tomomichi Kato, Sebastian Westermann, Ivan Mammarella, Bart Kruijt, Marta Galvagno, Marius Schmidt, Serge Rambal, J. Kurbatova, Sean P. Burns, Ettore D'Andrea, Chad Hanson, Vincenzo Magliulo, Anne Griebel, Brian D. Amiro, M. Goeckede, Enrique P. Sánchez-Cañete, Thomas L. Powell, Marcelo D. Nosetto, Cacilia Ewenz, Michael J. Liddell, Satoru Takanashi, Lukas Hörtnagl, Zulia Mayari Sanchez-Mejia, W.W.P. Jans, N. Pirk, Johan Neirynck, Rainer Steinbrecher, Lukas Siebicke, Matthias Peichl, Rachhpal S. Jassal, Costantino Sirca, Earth and Climate, Earth Sciences, Institute for Atmospheric and Earth System Research (INAR), INAR Physics, Micrometeorology and biogeochemical cycles, Viikki Plant Science Centre (ViPS), Ecosystem processes (INAR Forest Sciences), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Università degli studi della Tuscia [Viterbo], California State University [Sacramento], Michigan State University System, University of Virginia, Max Planck Institute for Biogeochemistry (MPI-BGC), Max-Planck-Gesellschaft, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Chinese Academy of Sciences [Beijing] (CAS), University of Manitoba [Winnipeg], Agroscope, McMaster University [Hamilton, Ontario], Lund University [Lund], University of Nebraska–Lincoln, University of Nebraska System, University of Melbourne, University of Antwerp (UA), Université de Liège, Finnish Meteorological Institute (FMI), University of California [Berkeley] (UC Berkeley), University of California (UC), University of Saskatchewan [Saskatoon] (U of S), Peoples Friendship University of Russia [RUDN University] (RUDN), The University of Western Australia (UWA), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of British Columbia (UBC), University of Colorado [Colorado Springs] (UCCS), Ohio State University [Columbus] (OSU), Humboldt University Of Berlin, University of Minnesota System, SILVA (SILVA), AgroParisTech-Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Interactions Sol Plante Atmosphère (UMR ISPA), Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Utah, University of Central Florida [Orlando] (UCF), Thunen Institute of Climate-Smart Agriculture, Department of Environmental Systems Science [ETH Zürich] (D-USYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fondazione Edmund Mach - Edmund Mach Foundation [Italie] (FEM), Aarhus University [Aarhus], University of Technology Sydney (UTS), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), NASA Goddard Space Flight Center (GSFC), Argonne National Laboratory [Lemont] (ANL), Université Laval [Québec] (ULaval), Universidade de São Paulo = University of São Paulo (USP), Pennsylvania State University (Penn State), Penn State System, Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), University of Wisconsin-Madison, Vrije Universiteit Amsterdam [Amsterdam] (VU), Centro de Investigaciones Biológicas (CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Shanxi University (SXU), Worcester State University [Worcester], Czech Academy of Sciences [Prague] (CAS), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UCL - SST/ELI/ELIE - Environmental Sciences, GILBERTO PASTORELLO, Lawrence Berkeley National Laboratory, THOMAS ANDREW BLACK, University of British Columbia, PETER D. BLANKEN, University of Colorado, GIL BOHRER, Ohio State University, JULIA BOIKE, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research / Humboldt-Universität zu Berlin, PAUL V. BOLSTAD, University of Minnesota, JEAN-MARC BONNEFOND, ISPA Bordeaux Sciences Agro, DAVID R. BOWLING, University of Utah, ROSVEL BRACHO, University of Florida, JASON BRODEUR, McMaster University, CHRISTIAN BRÜMMER, Thünen Institute of Climate-Smart Agriculture, NINA BUCHMANN, ETH Zurich, BENOIT BURBAN, INRAE UMR ECOFOG, AGNES DE GRANDCOURT, UMR Eco&Sols, CIRAD, ANNE DE LIGNE, University of Liege, RAIMUNDO COSME DE OLIVEIRA JUNIOR, CPATU, HAN DOLMAN, Universiteit Amsterdam, FRANCISCO DOMINGO, CSIC, GANG DONG, Shanxi University, SABINA DORE, HydroFocus, PIERPAOLO DUCE, National Research Council of Italy, MARTA GALVAGNO, Environmental Protection Agency of Aosta Valley, MANA GHARUN, ETH Zurich, DAMIANO GIANELLE, Fondazione Edmund Mach, MARCIN JACKOWICZ-KORCZYNSKI, Lund University / Aarhus University, DALIBOR JANOUS, Global Change Research Institute of the Czech Academy of Sciences, WILMA JANS, Wageningen University and Research, RACHHPAL JASSAL, University of British Columbia, SHICHENG JIANG, Northeast Normal University, ANA LÓPEZ-BALLESTEROS, Trinity College Dublin, EFRÉN LÓPEZ-BLANCO, Aarhus University, BENJAMIN LOUBET, Université Paris-Saclay, DENIS LOUSTAU, ISPA - INRA, JOHANNES LÜERS, University of Bayreuth, JOHAN NEIRYNCK, Research Institute for Nature and Forest, ZORAN NESIC, University of British Columbia, GIACOMO NICOLINI, University of Tuscia / CMCC, ASKO NOORMETS, Texas A&M University, MATTHEW NORTHWOOD, Charles Darwin University, KIMBERLY NOVICK, Indiana University Bloomington, MARILYN ROLAND, University of Antwerp, SIMONE SABBATINI, University of Tuscia, TORSTEN SACHS, GFZ German Research Centre for Geosciences, SCOTT R. SALESKA, University of Arizona, ENRIQUE P. SÁNCHEZ-CAÑETE, University of Granada / CEAMA-IISTA, ZULIA M. SANCHEZ-MEJIA, Instituto Tecnológico de Sonora, RAINER STEINBRECHER, Karlsruhe Institute of Technology, ROBERT M. STEVENS, Sentek Pty Ltd, COVE STURTEVANT, National Ecological Observatory Network Program, ANDY SUYKER, University of Nebraska-Lincoln, TORBERN TAGESSON, Lund University / University of Copenhagen, SATORU TAKANASHI, Forestry and Forest Products Research Institute, DOMENICO VITALE, University of Tuscia / CMCC, NATALIA VYGODSKAYA, Russian Academy of Sciences, JEFFREY P. WALKER, Monash University, ELIZABETH WALTER-SHEA, University of Nebraska-Lincoln, HUIMIN WANG, Chinese Academy of Sciences, ROBIN WEBER, University of California Berkeley, SEBASTIAN WESTERMANN, Instituto Nacional de Tecnologia Agropecuaria (INTA), CHRISTIAN WILLE, GFZ German Research Centre for Geosciences, STEVEN WOFSY, Harvard University, GEORG WOHLFAHRT, University of Innsbruck, SEBASTIAN WOLF, ETH Zurich, WILLIAM WOODGATE, CSIRO Land and Water, YUELIN LI, Chinese Academy of Sciences, DONATELLA ZONA, San Diego State University / University of Sheffield, DEB AGARWAL, Lawrence Berkeley National Laboratory, SEBASTIEN BIRAUD, Lawrence Berkeley National Laboratory, MARGARET TORN, Lawrence Berkeley National Laboratory, DARIO PAPALE, University of Tuscia / CMCC., ALLISON DUNN, Worcester State University, JIRÍ DUSEK, Global Change Research Institute of the Czech Academy of Sciences, DEREK EAMUS, University of Technology Sydney, UWE EICHELMANN, Technische Universität Dresden, HOUSEN CHU, Lawrence Berkeley National Laboratory, DANIELLE CHRISTIANSON, Lawrence Berkeley National Laboratory, YOU-WEI CHEAH, Lawrence Berkeley National Laboratory, CRISTINA POINDEXTER, California State University, JIQUAN CHEN, Michigan State University, ABDELRAHMAN ELBASHANDY, Lawrence Berkeley National Laboratory, MARTY HUMPHREY, University of Virginia, PETER ISAAC, TERN Ecosystrem Processes, DIEGO POLIDORI, University of Tuscia / CMCC, ALESSIO RIBECA, University of Tuscia / CMCC, CATHARINE VAN INGEN, Lawrence Berkeley National Laboratory, LEIMINGZ HANG, Chinese Academy of Sciences, BRIAN AMIRO, University of Manitoba, CHRISTOF AMMANN, Agroscope Research Institute, M. ALTAF ARAIN, McMaster University, JONAS ARDÖ, Lund University, TIMOTHY ARKEBAUER, University of Nebraska-Lincoln, STEFAN K. ARNDT, The University of Melbourne, NICOLA ARRIGA, University of Antwerp / Joint Research Centre, MARC AUBINET, University of Liege, MIKA AURELA, Finnish Meteorological Institute, DENNIS BALDOCCHI, University of California Berkeley, ALAN BARR, University of Saskatchewan / Environment and Climate Change Canada, DAMIEN BONAL, Université de Lorraine, SEAN P. BURNS, University of Colorado / National Center for Atmospheric Research, PAULINE BUYSSE, Université Paris-Saclay, PETER CALE, Australian Landscape Trust, MAURO CAVAGNA, Fondazione Edmund Mach, PIERRE CELLIER, Université Paris-Saclay, SHIPING CHEN, Chinese Academy of Sciences, ISAAC CHINI, Fondazione Edmund Mach, TORBEN R . CHRISTENSEN, Aarhus University, JAMES CLEVERLY, University of Technology Sydney, ALESSIO COLLALTI, University of Tuscia / National Research Council of Italy, CLAUDIA CONSALVO, University of Tuscia / National Research Council of Italy, BRUCE D. COOK, NASA Goddard Space Flight Center, DAVID COOK, Argonne National Laboratory, CAROLE COURSOLLE, Natural Resources Canada / Université Laval, EDOARDO CREMONESE, Climate Change Unit, PETER S. CURTIS, Ohio State University, ETTORE DANDREA, National Research Council of Italy, HUMBERTO DA ROCHA, USP, XIAOQIN DAI, Chinese Academy of Sciences, KENNETH J. DAVIS, The Pennsylvania State University, BRUNO DE CINTI, National Research Council of Italy, NICOLAS DELPIERRE, Université Paris-Saclay, ANKUR R . DESAI, University of Wisconsin-Madison, CARLOS MARCELO DI BELLA, Facultad de Agronomía, UBA, Buenos Aires., PAUL DI TOMMASI, National Research Council of Italy, ERIC DUFRÊNE, Université Paris-Saclay, MARIUS SCHMIDT, Agrosphere (IBG3), HATIM ABDALLA M. ELKHIDIR, ElObeid Research Station, WERNER EUGSTER, ETH Zurich, CACILIA M. EWENZ, TERN Ecosystem Processes Central Node, BRENT EWERS, University of Wyoming, DANIELA FAMULARI, National Research Council of Italy, SILVANO FARES, National Research Council of Italy / Research Centre for Forestry and Wood, IRIS FEIGENWINTER, ETH Zurich, ANDREW FEITZ, Geoscience Australia, RASMUS FENSHOLT, University of Copenhagen, GIANLUCA FILIPPA, Environmental Protection Agency of Aosta Valley, MARC FISCHER, Lawrence Berkeley National Laboratory, JOHN FRANK, USDA Forest Service, BERT GIELEN, University of Antwerp, BENIAMINO GIOLI, National Research Council of Italy, ANATOLY GITELSON, University of Nebraska-Lincoln, IGNACIO BALLARIN GODED, Joint Research Centre, MATHIAS GOECKEDE, University of Nebraska-Lincoln, ALLEN H. GOLDSTEIN, University of California Berkeley, CHRISTOPHER M. GOUGH, Virginia Commonwealth University, MICHAEL L. GOULDEN, University of California, ALEXANDER GRAF, Forschungszentrum Jülich, ANNE GRIEBEL, The University of Melbourne, CARSTEN GRUENING, Joint Research Centre, THOMAS GRÜNWALD, Technische Universität Dresden, ALBIN HAMMERLE, University of Innsbruck, SHIJIE HAN, Henan University / Chinese Academy of Sciences, XINGGUO HAN, Chinese Academy of Sciences, BIRGER ULF HANSEN, University of Copenhagen, CHAD HANSON, Oregon State University, JUHA HATAKKA, Finnish Meteorological Institute, YONGTAO HE, Chinese Academy of Sciences / University of Chinese Academy of Sciences, MARKUS HEHN, Technische Universität Dresden, BERNARD HEINESCH, University of Liege, NINA HINKO-NAJERA, The University of Melbourne, LUKAS HÖRTNAGL, ETH Zurich, LINDSAY HUTLEY, Charles Darwin University, ANDREAS IBROM, Technical University of Denmark, HIROKI IKAWA, National Agriculture and Food Research Organization, TOMOMICHI KATO, Hokkaido University, MYROSLAVA KHOMIK, McMaster University / Geography and Environmental Management, JANINA KLATT, Karlsruhe Institute of Technology, ALEXANDER KNOHL, University of Goettingen, SARA KNOX, The University of British Columbia, HIDEKI KOBAYASHI, Institute of Arctic Climate and Environment Research, GEORGIA KOERBER, University of Adelaide, OLAF KOLLE, Max Planck Institute for Biogeochemistry, YOSHIKO KOSUGI, Kyoto University, AYUMI KOTANI, Nagoya University, ANDREW KOWALSKI, University of Granada, BART KRUIJT, Wageningen University, JULIA KURBATOVA, Russian Academy of Sciences, WERNER L. KUTSCH, ICOS ERIC, HYOJUNG KWON, Oregon State University, SAMULI LAUNIAINEN, Natural Resources Institute Finland, TUOMAS LAURILA, Finnish Meteorological Institute, BEV LAW, Oregon State University, RAY LEUNING, In memoriam, YINGNIAN LI, Chinese Academy of Sciences, MICHAEL LIDDELL, James Cook University, JEAN-MARC LIMOUSIN, Univ Montpellier, KARL SCHNEIDER, University of Cologne, MARRYANNA LION, Forest Research Institute Malaysia, ADAM J. LISKA, University of Nebraska-Lincoln, ANNALEA LOHILA, Finnish Meteorological Institute / University of Helsinki, ANTJE LUCAS-MOFFAT, Thünen Institute of Climate-Smart Agriculture / Centre for Agrometeorological Research, SIYAN MA, University of California Berkeley, CRAIG MACFARLANE, CSIRO Land and Water, VINCENZO MAGLIULO, National Research Council of Italy, REGINE MAIER, ETH Zurich, IVAN MAMMARELLA, University of Helsinki, GIOVANNI MANCA, Joint Research Centre, BARBARA MARCOLLA, Fondazione Edmund Mach, HANK A . MARGOLIS, Université Laval, SERENA MARRAS, CMCC / University of Sassari, WILLIAM MASSMAN, USDA Forest Service, MIKHAIL MASTEPANOV, Aarhus University / University of Oulu, ROSER MATAMALA, Argonne National Laboratory, JACLYN HATALA MATTHES, Wellesley College, FRANCESCO MAZZENGA, National Research Council of Italy, HARRY MCCAUGHEY, Queen’s University, IAN MCHUGH, The University of Melbourne, ANDREW M. S. MCMILLAN, Environmental Analytics NZ, LUTZ MERBOLD, International Livestock Research Institute, WAYNE MEYER, University of Adelaide, TILDEN MEYERS, NOAA/OAR/Air Resources Laboratory, SCOTT D. MILLER, State University of New York at Albany, STEFANO MINERBI, Forest Department of South Tyrol, UTA MODEROW, Technische Universität Dresden, RUSSELL K. MONSON, University of Arizona, LEONARDO MONTAGNANI, Forest Department of South Tyrol / Free University of Bolzano, CAITLIN E. MOORE, University of Illinois at Urbana-Champaign, EDDY MOORS, IHE Delft / VU Amsterdam, VIRGINIE MOREAUX, ISPA / University Grenoble Alpes, CHRISTINE MOUREAUX, University of Liege, J. WILLIAM MUNGER, Harvard University, TARO NAKAI, National Taiwan University / University of Alaska Fairbanks, MARCELO NOSETTO, Instituto de Matemática Aplicada San Luis / UNER, YANN NOUVELLON, Univ Montpellier-CIRAD-INRA-IRD-Montpellier SupAgro, WALTER OECHEL, San Diego State University / University of Exeter, JORGEN EIVIND OLESEN, Aarhus University, JEAN-MARC OURCIVAL, Univ Montpellier, SHIRLEY A. PAPUGA, Wayne State University, FRANS-JAN PARMENTIER, Lund University / University of Oslo, EUGENIE PAUL-LIMOGES, University of Zurich, MARIAN PAVELKA, Global Change Research Institute of the Czech Academy of Sciences, MATTHIAS PEICHL, Swedish University of Agricultural Sciences, ELISE PENDALL, Western Sydney University, RICHARD P. PHILLIPS, Indiana University Bloomington, KIM PILEGAARD, Technical University of Denmark, NORBERT PIRK, Lund University / CSIRO Land and Water, GABRIELA POSSE, Instituto Nacional de Tecnologia Agropecuaria (INTA), THOMAS POWELL, Lawrence Berkeley National Laboratory, HEIKO PRASSE, Technische Universität Dresden, SUZANNE M. PROBER, CSIRO Land and Water, SERGE RAMBAL, Univ Montpellier, ÜLLAR RANNIK, University of Helsinki, DAVID REED, Michigan State University, VICTOR RESCO DE DIOS, Western Sydney University / Southwest University of Science and Technology, NATALIA RESTREPO-COUPE, University of Arizona, BORJA R. REVERTER, Universidade Federal da Paraiba, HANS PETER SCHMID, Karlsruhe Institute of Technology, FREDERIK SCHRADER, Federal Research Institute of Rural Areas, IVAN SCHRODER, Geoscience Australia, RUSSELL L. SCOTT, Southwest Watershed Research Center, PAVEL SEDLÁK, Global Change Research Institute of the Czech Academy of Sciences / Institute of Atmospheric Physics of the Czech Academy of Sciences, PENÉLOPE SERRANO-ORTÍZ, CEAMA-IISTA / University of Granada, CHANGLIANG SHAO, Chinese Academy of Agricultural Sciences, PEILI SHI, Chinese Academy of Sciences, IVAN SHIRONYA, Russian Academy of Sciences, LUKAS SIEBICKE, Bioclimatology, University of Goettingen, LADISLAV SIGUT, Global Change Research Institute of the Czech Academy of Sciences, RICHARD SILBERSTEIN, University of Western Australia / Edith Cowan University, COSTANTINO SIRCA, CMCC / University of Sassari, DONATELLA SPANO, CMCC / University of Sassari, YANHONG TANG, Peking University, NIGEL TAPPER, Monash University, JONATHAN THOM, University of Wisconsin-Madison, FRANK TIEDEMANN, University of Goettingen, MICHELE TOMASSUCCI, University of Tuscia / Terrasystem srl, JUHA-PEKKA TUOVINEN, Finnish Meteorological Institute, SHAWN URBANSKI, Rocky Mountain Research Station, RICCARDO VALENTINI, University of Tuscia / CMCC, MICHIEL VAN DER MOLEN, Wageningen University, EVA VAN GORSEL, Australian National University Canberra, KO VAN HUISSTEDEN, Vrije Universiteit Amsterdam, ANDREJ VARLAGIN, Russian Academy of Sciences, JOSEPH VERFAILLIE, University of California Berkeley, TIMO VESALA, University of Helsinki, CAROLINE VINCKE, Chinese Academy of Sciences, ROBERTO ZAMPEDRI, Fondazione Edmund Mach, JUNHUI ZHANG, Chinese Academy of Sciences, GUOYI ZHOU, Nanjing University of Information Science & Technology, NAAMA RAZ-YASEEF, Lawrence Berkeley National Laboratory, ERIC BEAMESDERFER, McMaster University, CARLO TROTTA, University of Tuscia, ELEONORA CANFORA, University of Tuscia / CMCC, LUCA BELELLI MARCHESINI, Fondazione Edmund Mach / RUDN University, ONIL BERGERON, Ministère du Développement durable de l’Environnement et de la Lutte contre les changements climatiques, JASON BERINGER, University of Western Australia, CHRISTIAN BERNHOFER, Technische Universität Dresden, DANIEL BERVEILLER, Université Paris-Saclay, and DAVE BILLESBACH, University of Nebraska-Lincoln
- Subjects
Meteorologie en Luchtkwaliteit ,Data Descriptor ,010504 meteorology & atmospheric sciences ,Settore AGR/05 - ASSESTAMENTO FORESTALE E SELVICOLTURA ,dataset provides ecosystem ,UNCERTAINTY ,Eddy covariance ,Observation météorologique ,01 natural sciences ,ecosystem-scale data ,lcsh:Science ,SITES ,Energy ,Respiration ,Statistics ,Uncertainty ,Carbon cycle ,Biological measurements ,Terrestrial biome ,RESPIRATION ,gapfilling ,[SDE]Environmental Sciences ,Assimilation ,Anhídrid carbònic ,ddc:500 ,Net ecosystem exchange ,Écosystème ,STORAGE ,Information Systems ,Statistics and Probability ,ecosystem approaches [EN] ,Meteorology and Air Quality ,ASSIMILATION ,Library and Information Sciences ,Education ,collection [EN] ,Donnée climatique ,Data collection ,Water ,15. Life on land ,Earth system science ,Climate Resilience ,Klimaatbestendigheid ,lcsh:Q ,processing ,Climate sciences ,Ecophysiology ,Storage ,Oceanography, Hydrology, Water Resources ,010501 environmental sciences ,CARBON-DIOXIDE ,ENERGY-BALANCE CLOSURE ,ddc:550 ,Échange d'énergie ,FLUXNET2015 ,Biosphere ,Energy balance closure ,fluxnet ,Computer Science Applications ,Collecte de données ,Energia ,P01 - Conservation de la nature et ressources foncières ,Statistics, Probability and Uncertainty ,INTERANNUAL VARIABILITY ,Eddy Covariance ,SDG 6 - Clean Water and Sanitation ,Engineering sciences. Technology ,Sensoriamento Remoto ,FLUX ,1171 Geosciences ,Consistency (database systems) ,eau ,Life Science ,Time series ,Remote sensing studies ,Measurement device ,0105 earth and related environmental sciences ,Remote sensing ,Ecosystem respiration and photosynthetic ,WIMEK ,NET ECOSYSTEM EXCHANGE ,Pipeline (software) ,Environmental sciences ,Metadata ,Earth sciences ,Carbon dioxide ,13. Climate action ,Environmental science ,Probability and Uncertainty ,Water Systems and Global Change ,Dioxyde de carbone - Abstract
The FLUXNET2015 dataset provides ecosystem-scale data on CO2, water, and energy exchange between the biosphere and the atmosphere, and other meteorological and biological measurements, from 212 sites around the globe (over 1500 site-years, up to and including year 2014). These sites, independently managed and operated, voluntarily contributed their data to create global datasets. Data were quality controlled and processed using uniform methods, to improve consistency and intercomparability across sites. The dataset is already being used in a number of applications, including ecophysiology studies, remote sensing studies, and development of ecosystem and Earth system models. FLUXNET2015 includes derived-data products, such as gap-flled time series, ecosystem respiration and photosynthetic uptake estimates, estimation of uncertainties, and metadata about the measurements, presented for the frst time in this paper. In addition, 206 of these sites are for the frst time distributed under a Creative Commons (CC-BY 4.0) license. This paper details this enhanced dataset and the processing methods, now made available as open-source codes, making the dataset more accessible, transparent, and reproducible., European Union (EU), United States Department of Energy (DOE)
- Published
- 2020
219. Capturing static and dynamic correlation with $\Delta \text{NO}$-MP2 and $\Delta \text{NO}$-CCSD
- Author
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Hollett, Joshua W., Loos, Pierre-Francois, University of Manitoba, University of Manitoba [Winnipeg], Groupe Méthodes et outils de la chimie quantique (LCPQ) (GMO), Laboratoire de Chimie et Physique Quantiques (LCPQ), Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse)
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[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,Condensed Matter - Strongly Correlated Electrons ,Physics - Chemical Physics ,Physics::Atomic and Molecular Clusters ,[CHIM]Chemical Sciences ,Physics::Chemical Physics ,Physics - Computational Physics - Abstract
The $\Delta \text{NO}$ method for static correlation is combined with second-order M{\o}ller-Plesset perturbation theory (MP2) and coupled-cluster singles and doubles (CCSD) to account for dynamic correlation. The MP2 and CCSD expressions are adapted from finite-temperature CCSD, which includes orbital occupancies and vacancies, and expanded orbital summations. Correlation is partitioned with the aid of damping factors incorporated into the MP2 and CCSD residual equations. Potential energy curves for a selection of diatomics are in good agreement with extrapolated full configuration interaction results (exFCI), and on par with conventional multireference approaches., Comment: 29 pages, 7 figures
- Published
- 2020
220. New evidences of diamane synthesis
- Author
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Piazza, Fabrice, Monthioux, Marc, Puech, Pascal, Gerber, I.C., Gough, Kathleen, Laboratorio de Nanociencia, Pontificia Universidad Católica Madre y Maestra, Matériaux Multi-fonctionnels et Multi-échelles (CEMES-M3), Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Department of Chemistry, University of Manitoba, PUCMM-CNRS Research Convention, Pontificia Universidad Católica Madre y Maestra (PUCMM), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and University of Manitoba [Winnipeg]
- Subjects
[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
International audience
- Published
- 2019
221. Finding Information on Non-Rectangular Interfaces
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Anne Roudaut, Florine Simon, Pourang Irani, Marcos Serrano, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), University of Manitoba (CANADA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), University of Bristol (UNITED KINGDOM), Etude de L’Interaction Personne SystèmE (IRIT-ELIPSE), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, University of Bristol [Bristol], and University of Manitoba [Winnipeg]
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Visual search ,Non-rectangular interface ,Computer science ,05 social sciences ,Eye movement ,020207 software engineering ,02 engineering and technology ,Visual search tasks ,Interface homme-machine ,User interfaces design ,Visualization ,User interface design ,Visualisation ,Human–computer interaction ,0202 electrical engineering, electronic engineering, information engineering ,0501 psychology and cognitive sciences ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,050107 human factors - Abstract
International audience; With upcoming breakthroughs in free-form display technologies, new user interface design challenges have emerged. Here, we investigate a question, which has been widely explored on traditional GUIs but unexplored on non-rectangular interfaces: what are the user strategies in terms of visual search when information is not presented in a traditional rectangular layout? To achieve this, we present two complementary studies investigating eye movements in different visual search tasks. Our results unveil which areas are seen first according to different visual structures. By doing so we address the question of where to place relevant content for the UI designers of non-rectangular displays.
- Published
- 2019
222. G-Sparks: Glanceable Sparklines on Smartwatches
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Neshati, A., Sakamoto, Y., Leboe-Mcgowan, L. C., Leboe-Mcgowan, J., Marcos Serrano, Irani, P., Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), University of Manitoba (CANADA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), Institut de Recherche en Informatique de Toulouse - IRIT (Toulouse, France), University of Manitoba [Winnipeg], Etude de L’Interaction Personne SystèmE (IRIT-ELIPSE), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), and Université Fédérale Toulouse Midi-Pyrénées
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Small screen ,05 social sciences ,Line graph ,020207 software engineering ,02 engineering and technology ,Compression methods ,Interface homme-machine ,000 computer science ,Smartwatch visualization, small screen, line graph, compression methods, spark lines ,Smartwatch visualization ,0202 electrical engineering, electronic engineering, information engineering ,0501 psychology and cognitive sciences ,Spark lines ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,050107 human factors - Abstract
Proceedings of Graphics Interface 2019, Kingston, Ontario, Canada, 28 - 31 May 2019, Optimizing the use of a small display while presenting graphic data such as line charts is challenging. To tackle this, we propose GSparks, a compact visual representation of glanceable line graphs for smartwatches. Our exploration primarily considered the suitable compression axes for time-series charts. In a first study we examine the optimal line-graph compression approach without compromising perceptual metrics, such as slope or height detections. We evaluated compressions of line segments, the elementary unit of a line graph, along the x-axis, y-axis, and xyaxes. Contrary to intuition, we find that condensing graphs yield more accurate reading of height estimations than non-compressed graphs, but only when these are compressed along the x-axis. Building from this result, we study the effect of an x-axis compression on users' ability to perform "glanceable" analytic tasks with actual data. Glanceable tasks include quick perceptual judgements of graph properties. Using bio-metric data (heart rate), we find that shrinking a line graph to the point of representing one data sample per pixel does not compromise legibility. As expected, such type of compression also has the effect of minimizing the needed amount of flicking to interact with such graphs. From our results, we offer guidelines to application designers needing to integrate line charts into smartwatch apps.
- Published
- 2019
223. Number of source patches required for population persistence in a source-sink metapopulation with explicit movement
- Author
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Steve Kirkland, Julien Arino, Nicolas Bajeux, University of Manitoba, University of Manitoba [Winnipeg], and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)
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0301 basic medicine ,Metapopulations ,Food Chain ,Occupancy ,Applied linear algebra ,[SDV]Life Sciences [q-bio] ,General Mathematics ,Population persistence ,Population Dynamics ,Immunology ,Population ,Metapopulation ,Models, Biological ,General Biochemistry, Genetics and Molecular Biology ,Sink (geography) ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Humans ,Applied mathematics ,Quantitative Biology::Populations and Evolution ,Computer Simulation ,education ,Ecosystem ,General Environmental Science ,Mathematics ,Pharmacology ,Source sink ,Source–sink dynamics ,geography ,education.field_of_study ,geography.geographical_feature_category ,General Neuroscience ,Mathematical Concepts ,Threshold number ,030104 developmental biology ,Computational Theory and Mathematics ,030220 oncology & carcinogenesis ,Linear Models ,Source-sink dynamics ,General Agricultural and Biological Sciences - Abstract
International audience; We consider a simple metapopulation model with explicit movement of individuals between patches, in which each patch is either a source or a sink. We prove that similarly to the case of patch occupancy metapopulations with implicit movement, there exists a threshold number of source patches such that the population potentially becomes extinct below the threshold and established above the threshold. In the case where the matrix describing the movement of populations between spatial locations is irreducible, the result is global; further, assuming a complete mobility graph with equal movement rates, we use the principle of equitable partitions to obtain an explicit expression for the threshold. Brief numerical considerations follow.
- Published
- 2019
224. Critical view of anaphylaxis epidemiology: open questions and new perspectives
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Nikolaos G. Papadopoulos, Nicolas Molinari, Luciana Kase Tanno, Margitta Worm, Ana Luiza Bierrenbach, Pascal Demoly, Yoon-Seok Chang, Thomas B. Casale, Victoria Cardona, Bernard Yu-Hor Thong, Moises A. Calderon, F. Estelle R. Simons, Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, University of Manitoba [Winnipeg], Vall d'Hebron University Hospital [Barcelona], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Section of Allergy and Clinical Immunology [London, UK], Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], UPC Research Laboratories, Allergy Department, University of South Florida [Tampa] (USF), and University of Manitoba
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lcsh:Immunologic diseases. Allergy ,0301 basic medicine ,medicine.medical_specialty ,Allergy ,Lydia Becker Institute ,Epidemiology ,[SDV]Life Sciences [q-bio] ,Review ,World Health Organization ,World health ,03 medical and health sciences ,0302 clinical medicine ,International Classification of Diseases ,ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation ,medicine ,Cumulative incidence ,Intensive care medicine ,Anaphylaxis ,ComputingMilieux_MISCELLANEOUS ,business.industry ,General Medicine ,Classification ,medicine.disease ,Rare diseases ,3. Good health ,030104 developmental biology ,030228 respiratory system ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,lcsh:RC581-607 ,business - Abstract
In contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can differ widely depending on a number of variables. In the current document we reviewed the forms on which anaphylaxis has been defined and classified; and how it can affect epidemiological data. With regards to the methods used to capture morbidity statistics, we observed the impact of the anaphylaxis coding utilizing the World Health Organization’s International Classification of Diseases. As an outcome and depending on the anaphylaxis definition, we extracted the cumulative incidence, which may not reflect the real number of new cases. The new ICD-11 anaphylaxis subsection developments and critical view of morbidity statistics data are discussed in order to reach new perspectives on anaphylaxis epidemiology.
- Published
- 2018
225. Seasonal and habitat-based variations in vertical export of biogenic sea-ice proxies in Hudson Bay
- Author
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Tiia Luostarinen, Kaarina Weckström, Jens Ehn, Michelle Kamula, Amanda Burson, Aura Diaz, Guillaume Massé, Suzanne McGowan, Zou Zou Kuzyk, Maija Heikkilä, Helsinki Institute of Sustainability Science (HELSUS), Faculty of Biological and Environmental Sciences [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Geological Survey of Denmark and Greenland (GEUS), Centre for Earth Observation Science [Winnipeg], University of Manitoba [Winnipeg], British Antarctic Survey (BAS), Natural Environment Research Council (NERC), University of Nottingham, UK (UON), Variabilité de l'Océan et de la Glace de mer (VOG), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Netherlands Institute of Ecology (NIOO-KNAW), Ecosystems and Environment Research Programme, Environmental Change Research Unit (ECRU), and Aquatic Ecology (AqE)
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Diatoms ,Canada ,Dinoflagellate cysts ,Quebec ,Fresh-water ,[SDU.STU]Sciences of the Universe [physics]/Earth Sciences ,Biomarker ,North-atlantic ,1181 Ecology, evolutionary biology ,General Earth and Planetary Sciences ,Variability ,Manitounuk sound ,Late quaternary ,General Environmental Science - Abstract
Despite their wide use in past sea-ice reconstructions, the seasonal, habitat and species-based sources of sedimentary sea-ice proxies are poorly understood. Here, we conduct direct observations of the community composition of diatoms, dinoflagellate cysts and highly branched isoprenoid lipids within the sea ice, water column, sediment traps and sediment surface in the Belcher Islands Archipelago, Hudson Bay throughout spring 2019. We find that Arctic diatom and dinoflagellate cysts species commonly used as sea-ice proxies appear to be only indirectly linked to sea-ice conditions, and that the sediment assemblages of these groups overrepresent summertime pelagic blooms. Species contributing to the diverse sea-ice diatom communities are rare in the sediment. Dinoflagellate cysts form a typical Arctic assemblage in the sediment, although they are virtually absent in the sea ice and water column in spring. We also find that certain highly branched isoprenoid lipids that were previously considered indicators of open water, can be produced in sea-ice. We conclude that contextual knowledge and a multiproxy approach are necessary in reconstruction, encouraging further studies on the sources and controls of sea-ice proxy production in different geographic areas. Sedimentary assemblages of biogenic sea-ice proxies incorporate limited representation of the diverse sea-ice connected communities, according to direct springtime observations in the Belcher Islands Archipelago, Hudson Bay, Canada.Despite their wide use in past sea-ice reconstructions, the seasonal, habitat and species-based sources of sedimentary sea-ice proxies are poorly understood. Here, we conduct direct observations of the community composition of diatoms, dinoflagellate cysts and highly branched isoprenoid lipids within the sea ice, water column, sediment traps and sediment surface in the Belcher Islands Archipelago, Hudson Bay throughout spring 2019. We find that Arctic diatom and dinoflagellate cysts species commonly used as sea-ice proxies appear to be only indirectly linked to sea-ice conditions, and that the sediment assemblages of these groups overrepresent summertime pelagic blooms. Species contributing to the diverse sea-ice diatom communities are rare in the sediment. Dinoflagellate cysts form a typical Arctic assemblage in the sediment, although they are virtually absent in the sea ice and water column in spring. We also find that certain highly branched isoprenoid lipids that were previously considered indicators of open water, can be produced in sea-ice. We conclude that contextual knowledge and a multiproxy approach are necessary in reconstruction, encouraging further studies on the sources and controls of sea-ice proxy production in different geographic areas.
- Published
- 2023
226. Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells
- Author
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Michelle Pinault, Laure Peyta, Kathleen Jarnouen, Stephan Chevalier, Cyrille Guimaraes, Grant M. Hatch, Pascal Loyer, Jean-François Dumas, Jean-Paul Pais de Barros, François Maillot, Stéphane Servais, Nutrition, croissance et cancer (U 1069) (N2C), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT), Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Lipides - Nutrition - Cancer (U866) (LNC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), University of Manitoba [Winnipeg], Ligue contre le CancerRégion Centre'Cancéropole Grand OuestGroupe Lipides Nutrition' 'Association CANCEN', Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Jonchère, Laurent, Nutrition, croissance et cancer ( N2C ), Université de Tours-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), CHRU Tours, and University of Manitoba, Canada
- Subjects
0301 basic medicine ,Bioenergetics ,Cardiolipins ,[SDV]Life Sciences [q-bio] ,Biophysics ,Respiratory chain ,Supercomplexes ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Oxidative phosphorylation ,Mitochondrion ,Biology ,Biochemistry ,Oxidative Phosphorylation ,[ SDV.CAN ] Life Sciences [q-bio]/Cancer ,Electron Transport ,03 medical and health sciences ,chemistry.chemical_compound ,Adenosine Triphosphate ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Cardiolipin ,Humans ,Cells, Cultured ,Mitochondrial network ,[ SDV ] Life Sciences [q-bio] ,030102 biochemistry & molecular biology ,ATP synthase ,Cell Biology ,Mitochondria ,Cell biology ,[SDV] Life Sciences [q-bio] ,030104 developmental biology ,chemistry ,Hepatocytes ,biology.protein ,ATP–ADP translocase ,Energy Metabolism ,Adenosine triphosphate ,Cardiolipin synthase - Abstract
International audience; Cardiolipin (CL) is a unique mitochondrial phospholipid potentially affecting many aspects of mitochondrial function/processes, i.e. energy production through oxidative phosphorylation. Most data focusing on implication of CL content and mitochondrial bioenergetics were performed in yeast or in cellular models of Barth syndrome. Previous work reported that increase in CL content leads to decrease in liver mitochondrial ATP synthesis yield. Therefore the aim of this study was to determine the effects of moderate decrease in CL content on mitochondrial bioenergetics in human hepatocytes. For this purpose, we generated a cardiolipin synthase knockdown (shCLS) in HepaRG hepatoma cells showing bioenergetics features similar to primary human hepatocytes. shCLS cells exhibited a 55% reduction in CLS gene and a 40% decrease in protein expression resulting in a 45% lower content in CL compared to control (shCTL) cells. Oxygen consumption was significantly reduced in shCLS cells compared to shCTL regardless of substrate used and energy state analyzed. Mitochondrial low molecular weight supercomplexes content was higher in shCLS cells (+ 60%) compared to shCTL. Significant fragmentation of the mitochondrial network was observed in shCLS cells compared to shCTL cells. Surprisingly, mitochondrial ATP synthesis was unchanged in shCLS compared to shCTL cells but exhibited a higher ATP:O ratio (+ 46%) in shCLS cells. Our results suggest that lowered respiratory chain activity induced by moderate reduction in CL content may be due to both destabilization of supercomplexes and mitochondrial network fragmentation. In addition, CL content may regulate mitochondrial ATP synthesis yield.
- Published
- 2016
227. A Novel Interaction Paradigm For Exploring Spatio-Temporal Data
- Author
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Cassat, Sabine, Serrano, Marcos, Dubois, Emmanuel, Irani, Pourang, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), University of Manitoba (CANADA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), Etude de L’Interaction Personne SystèmE (IRIT-ELIPSE), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier (UT3), University of Manitoba [Winnipeg], and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
- Subjects
Tangible interaction ,Spatio-temporal dataset ,Data visualization ,Intelligence artificielle ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] - Abstract
International audience; Complex spatio-temporal data is difficult to visualize and even further to interact with, especially by several users at the same time. However, visualization and exploration of such data are essential for experts to understand complex data environments, such as for mitigating the adverse effects of disease spread. This paper presents an alternative approach to that of current spatiotemporal data visualizations to access, interpret, and manipulate spatio-temporal datasets as a single user or as a team. Our approach uses tangible and visual tools such as mini-robots, tabletop displays and augmented reality tools, to facilitate the data exploration and interpretation. We also introduce a simple use case that illustrates one of the possible utilization of the system. While tangibles have been introduced to represent information, we are investigating manners in which we can depict even more complex datasets. Our system will provide a novel approach to manipulate 3D and 4D datasets that classic tools such as a 2D mouse or a tactile screen would not allow.
- Published
- 2018
228. Fatal anaphylaxis registries data support changes in the who anaphylaxis mortality coding rules
- Author
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Pascal Demoly, Ségolène Aymé, Luciana Kase Tanno, Isabella Annesi-Maesano, F. Estelle R. Simons, Moises A. Calderon, Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Emergency Department [São Paulo, Brazil], Hospital Sírio-Libanês [São Paulo, Brazil], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Pediatrics & Child Health [Winnipeg, Canada], Section of Allergy & Clinical Immunology [Winnipeg, Canada], University of Manitoba [Winnipeg]-University of Manitoba [Winnipeg], Section of Allergy and Clinical Immunology [London, UK], Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, Plateforme d'information et de services pour les maladies rares et les médicaments orphelins (Orphanet), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Broussais-Institut National de la Santé et de la Recherche Médicale (INSERM), and BMC, BMC
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0301 basic medicine ,medicine.medical_specialty ,Underlying cause of death ,[SDV]Life Sciences [q-bio] ,Pharmacology toxicology ,Review ,World Health Organization ,World health ,03 medical and health sciences ,0302 clinical medicine ,International Classification of Diseases ,Humans ,Medicine ,Genetics(clinical) ,Pharmacology (medical) ,Registries ,Mortality ,Intensive care medicine ,Anaphylaxis ,Genetics (clinical) ,Medicine(all) ,business.industry ,Clinical Coding ,Fatal anaphylaxis ,General Medicine ,medicine.disease ,Classification ,3. Good health ,[SDV] Life Sciences [q-bio] ,Hypersensitivity reaction ,030104 developmental biology ,030228 respiratory system ,Icd codes ,business ,Coding (social sciences) - Abstract
International audience; AbstractAnaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction. The difficulty of coding anaphylaxis fatalities under the World Health Organization (WHO) International Classification of Diseases (ICD) system is recognized as an important reason for under-notification of anaphylaxis deaths. On current death certificates, a limited number of ICD codes are valid as underlying causes of death, and death certificates do not include the word anaphylaxis per se. In this review, we provide evidences supporting the need for changes in WHO mortality coding rules and call for addition of anaphylaxis as an underlying cause of death on international death certificates. This publication will be included in support of a formal request to the WHO as a formal request for this move taking the 11th ICD revision.
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- 2017
229. TDome: a touch-enabled 6DOF interactive device for multi-display environments
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Pourang Irani, Marcos Serrano, Emmanuel Dubois, Houssem Saidi, Etude de L’Interaction Personne SystèmE (IRIT-ELIPSE), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, University of Manitoba [Winnipeg], Université Toulouse III - Paul Sabatier (UT3), Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), University of Manitoba (CANADA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
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Computer science ,Input device ,02 engineering and technology ,computer.software_genre ,Translation (geometry) ,Interface homme-machine ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,User studies ,Human–computer interaction ,Rolling device ,0202 electrical engineering, electronic engineering, information engineering ,0501 psychology and cognitive sciences ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,Set (psychology) ,050107 human factors ,Multimedia ,business.industry ,05 social sciences ,020207 software engineering ,Usability ,Intelligence artificielle ,Touch input ,Multi-display environments ,business ,computer ,Rotation (mathematics) ,Gesture - Abstract
The rapid evolution of multi-display environments (MDEs) has created a vacuum in need of novel input devices to optimize interaction in MDEs. In this paper, we propose TDome, a novel touch-enabled 6DOF input and output device to facilitate interactions in MDEs. TDome offers a private display as output, and multiple degrees of freedom as input by combining touch gestures on the display with physical rotation, roll and translation manipulations of the device. TDome allows versatile interactions that address major MDE tasks, which we illustrate through various proof-of-concept implementations: detect surrounding displays, select one display, transfer data across displays, reach distant displays and perform private interactions. We explore TDome's usability and suitability for MDEs through three user studies. First we explore combined physical+touch gestures from which we discard uncomfortable combinations. We experimentally validate their feasibility and come up with a set of 71 combined gestures that are comfortable and ensure a high success rate, i.e. that can be easily performed and efficiently detected. Finally, we collect user feedback to identify natural mappings between gestures and MDE interactions.
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- 2017
230. Visual Composition of Graphical Elements on Non-Rectangular Displays
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Anne Roudaut, Pourang Irani, Marcos Serrano, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), University of Manitoba (CANADA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), University of Bristol (UNITED KINGDOM), Etude de L’Interaction Personne SystèmE (IRIT-ELIPSE), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, University of Bristol [Bristol], University of Manitoba [Winnipeg], and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
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Computer science ,H5.2 ,Context (language use) ,02 engineering and technology ,Interface homme-machine ,Freeform display ,Set (abstract data type) ,Visual design guidelines ,Human–computer interaction ,Computer graphics (images) ,0202 electrical engineering, electronic engineering, information engineering ,0501 psychology and cognitive sciences ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,Non-rectangular display ,Composition (language) ,050107 human factors ,Graphical user interface ,Communication design ,business.industry ,05 social sciences ,020207 software engineering ,User interface ,Composition (visual arts) ,business - Abstract
International audience; Graphical user interfaces are composed of varying elements (text, images, etc.) whose visual arrangement has been relatively well established in the context of rectangular interfaces. The advent of non-rectangular displays questions this knowledge. In this paper we study how traditional content layouts can be adapted to fit different non-rectangular displays. We performed a first qualitative study where graphic designers fitted text and images into different non-rectangular displays. From the analysis of their output we generalize and adapt ten composition principles that have been proposed in the literature for rectangular displays. We evaluate the revised principles through a paired comparison questionnaire where 57 participants compared pairs of layouts. Using the Bradley-Terry-Luce model to analyze our data we show that some results contradict current conventions on visual design for rectangular displays. We then extracted the most interesting cases and conducted a follow up study with additional shapes to investigate how the principles generalize. From these results we propose a set of guidelines for designing visual content for non-rectangular displays.
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- 2017
231. Weaning age influences the severity of gastrointestinal microbiome shifts in dairy calves
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Jan C. Plaizier, Hooman Derakhshani, S. Li, S. J. Meale, Ehsan Khafipour, Paula Azevedo, Michael A. Steele, T. J. Devries, Unité Mixte de Recherches sur les Herbivores ( UMR 1213 Herbivores ), VetAgro Sup ( VAS ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique ( INRA ), Department of Animal Science, Texas A&M University [College Station], Department of Animal Bioscience, University of Guelph, Department of Agricultural Food and Nutrition Science, University of Alberta, Department of Medicine Microbiolology, University of Manitoba, Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), University of Manitoba [Winnipeg], Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, and Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
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0301 basic medicine ,Rumen ,Firmicutes ,[SDV]Life Sciences [q-bio] ,Science ,microbiome ,microbiote digestif ,Weaning ,Biology ,Carbohydrate metabolism ,Article ,fermentation ruminale ,03 medical and health sciences ,Feces ,âge au sevrage ,Animal science ,Animals ,calve ,Microbiome ,Phylogeny ,2. Zero hunger ,Multidisciplinary ,[ SDV ] Life Sciences [q-bio] ,Bacteroidetes ,veau ,Gastrointestinal Microbiome ,parasite gastro intestinal ,biology.organism_classification ,régime alimentaire ,030104 developmental biology ,Biochemistry ,Medicine ,Carbohydrate Metabolism ,Cattle ,Digestion - Abstract
Ruminants microbial consortium is responsible for ruminal fermentation, a process which converts fibrous feeds unsuitable for human consumption into desirable dairy and meat products, begins to establish soon after birth. However, it undergoes a significant transition when digestion shifts from the lower intestine to ruminal fermentation. We hypothesised that delaying the transition from a high milk diet to an exclusively solid food diet (weaning) would lessen the severity of changes in the gastrointestinal microbiome during this transition. β-diversity of ruminal and faecal microbiota shifted rapidly in early-weaned calves (6 weeks), whereas, a more gradual shift was observed in late-weaned calves (8 weeks) up to weaning. Bacteroidetes and Firmicutes were the most abundant ruminal phyla in pre- and post-weaned calves, respectively. Yet, the relative abundance of these phyla remained stable in faeces (P ≥ 0.391). Inferred gene families assigned to KEGG pathways revealed an increase in ruminal carbohydrate metabolism (P ≤ 0.009) at 9, compared to 5 weeks. Conversely, carbohydrate metabolism in faeces declined (P ≤ 0.002) following a change in weaning status (i.e., the shift from pre- to post-weaning). Our results indicate weaning later facilitates a more gradual shift in microbiota and could potentially explain the negative effects of early-weaning associated with feeding a high-plane of pre-weaning nutrition.
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- 2017
232. Capturing how age-friendly communities foster positive health, social participation and health equity: a study protocol of key components and processes that promote population health in aging Canadians
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Mélissa Généreux, Catherine Gabaude, Verena Menec, Catherine St-Pierre, Mathieu Roy, Yves Couturier, Parminder Raina, Marie-France Dubois, Mélanie Levasseur, Research Centre on Aging, Centre integré universitaire de santé et de services sociaux de l'Estrie (CIUSSS de l'Estrie - CHUS), Centre hospitalier universitaire de Sherbrooke, Department of Community Health Sciences, University of Manitoba, University of Manitoba [Winnipeg], McMaster University [Hamilton, Ontario], Laboratoire Ergonomie et Sciences Cognitives pour les Transports (IFSTTAR/TS2/LESCOT), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université de Lyon, and Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)
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Gerontology ,Male ,Aging ,SOCIAL ENGAGEMENT ,COMMUNITY PARTICIPATION ,Study Protocol ,0302 clinical medicine ,PERSONNE AGEE ,Residence Characteristics ,Surveys and Questionnaires ,Health care ,Medicine ,AGE-FRIENDLY CITIES ,030212 general & internal medicine ,Prospective Studies ,[SHS.SOCIO]Humanities and Social Sciences/Sociology ,Health Equity ,Population Health ,lcsh:Public aspects of medicine ,SOCIAL INVOLVEMENT ,Public relations ,16. Peace & justice ,Social engagement ,Social Participation ,STUDY ON AGING (CLSA) ,Health equity ,3. Good health ,INTEGRATION SOCIALE ,Female ,0305 other medical science ,medicine.medical_specialty ,Canada ,COMMUNITY INTEGRATION ,AGE-FRIENDLY MUNICIPALITIES ,Population health ,Health Promotion ,03 medical and health sciences ,SOCIETE ,030502 gerontology ,Humans ,SENIORS ,Social determinants of health ,Health policy ,Aged ,MIXED-METHOD DESIGN ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,lcsh:RA1-1270 ,CANADIAN LONGITUDINAL ,Health promotion ,Cross-Sectional Studies ,13. Climate action ,AGING ADULTS ,business ,Canadian longitudinal Study on Aging (CLSA) - Abstract
Background To address the challenges of the global aging population, the World Health Organization promoted age-friendly communities as a way to foster the development of active aging community initiatives. Accordingly, key components (i.e., policies, services and structures related to the communities’ physical and social environments) should be designed to be age-friendly and help all aging adults to live safely, enjoy good health and stay involved in their communities. Although age-friendly communities are believed to be a promising way to help aging Canadians lead healthy and active lives, little is known about which key components best foster positive health, social participation and health equity, and their underlying mechanisms. This study aims to better understand which and how key components of age-friendly communities best foster positive health, social participation and health equity in aging Canadians. Specifically, the research objectives are to: 1) Describe and compare age-friendly key components of communities across Canada 2) Identify key components best associated with positive health, social participation and health equity of aging adults 3) Explore how these key components foster positive health, social participation and health equity Methods A mixed-method sequential explanatory design will be used. The quantitative part will involve a survey of Canadian communities and secondary analysis of cross-sectional data from the Canadian Longitudinal Study on Aging (CLSA). The survey will include an age-friendly questionnaire targeting key components in seven domains: physical environment, housing options, social environment, opportunities for participation, community supports and healthcare services, transportation options, communication and information. The CLSA is a large, national prospective study representative of the Canadian aging population designed to examine health transitions and trajectories of adults as they age. In the qualitative part, a multiple case study will be conducted in five Canadian communities performing best on positive health, social participation and health equity. Discussion Building on new and existing collaborations and generating evidence from real-world interventions, the results of this project will help communities to promote age-friendly policies, services and structures which foster positive health, social participation and health equity at a population level.
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- 2017
233. Social and spatial effects on genetic variation between foraging flocks in a wild bird population
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Anna W. Santure, Jon Slate, Ben C. Sheldon, Damien R. Farine, Reinder Radersma, Colin J. Garroway, Isabelle De Cauwer, Edward Grey Institute of Field Ornithology, University of Oxford [Oxford], Department of Biology, Lund University, Lund, Sweden, Lund University [Lund, Sweden], Department of Biological Sciences, University of Manitoba, Winnipeg, MB, The University of Sheffield [Sheffield, U.K.], University of Auckland [Auckland], Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Department of Collective Behaviour, Max Planck Institute for Ornithology, Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Department of Biology, University of Konstanz, Konstanz, University of Oxford, Lund University [Lund], University of Manitoba [Winnipeg], and Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo (EEP))
- Subjects
0106 biological sciences ,0301 basic medicine ,Genotype ,Population Dynamics ,Population ,Population genetics ,Biology ,Polymorphism, Single Nucleotide ,010603 evolutionary biology ,01 natural sciences ,Homophily ,03 medical and health sciences ,Gene Frequency ,Genetics ,Animals ,Passeriformes ,Social Behavior ,10. No inequality ,Evolutionary dynamics ,education ,Allele frequency ,Ecology, Evolution, Behavior and Systematics ,ComputingMilieux_MISCELLANEOUS ,Parus ,Spatial Analysis ,education.field_of_study ,[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] ,Genetic Variation ,biology.organism_classification ,Heterophily ,Genetics, Population ,030104 developmental biology ,Genetic structure - Abstract
Social interactions are rarely random. In some instances animals exhibit homophily or heterophily, the tendency to interact with similar or dissimilar conspecifics respectively. Genetic homophily and heterophily influence the evolutionary dynamics of populations, because they potentially affect sexual and social selection. Here we investigate the link between social interactions and allele frequencies in foraging flocks of great tits (Parus major) over three consecutive years. We constructed co-occurrence networks which explicitly described the splitting and merging of 85,602 flocks through time (fission-fusion dynamics), at 60 feeding sites. Of the 1711 birds in those flocks we genotyped 962 individuals at 4701 autosomal single- nucleotide polymorphisms (SNPs). By combining genome-wide genotyping with repeated field observations of the same individuals we were able to investigate links between social structure and allele frequencies at a much finer scale than was previously possible. We explicitly accounted for potential spatial effects underlying genetic structure at the population level. We modelled social structure and spatial configuration of great tit fission-fusion dynamics with eigenvector maps. Variance partitioning revealed that allele frequencies were strongly affected by group fidelity (explaining 27-45% of variance) as individuals tended to maintain associations with the same conspecifics. These conspecifics were genetically more dissimilar than expected, shown by genome-wide heterophily for pure social (i.e. space-independent) grouping preferences. Genome-wide homophily was linked to spatial configuration, indicating spatial segregation of genotypes. We did not find evidence for homophily or heterophily for putative socially relevant candidate genes or any other SNP markers. Together, these results demonstrate the importance of distinguishing social and spatial processes in determining population structure.
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- 2017
234. Evolution of immune genes is associated with the Black Death
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Jennifer Klunk, Tauras P. Vilgalys, Christian E. Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I. Patino, Rebecca Redfern, Sharon N. DeWitte, Julia A. Gamble, Jesper L. Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F. Brinkworth, Dominique Missiakas, Guy A. Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N. Poinar, Luis B. Barreiro, McMaster Ancient DNA Center [Hamilton, Ontario], McMaster University [Hamilton, Ontario], Daicel Arbor Biosciences [Ann Arbor, MI], University of Chicago, Yersinia, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Museum of London, University of South Carolina [Columbia], University of Manitoba [Winnipeg], University of Southern Denmark (SDU), Indiana University [Bloomington], Indiana University System, Rutgers University [Newark], Rutgers University System (Rutgers), Université de Montréal (UdeM), University of Michigan [Ann Arbor], University of Michigan System, Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], University of California [San Francisco] (UC San Francisco), University of California (UC), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, McGill University = Université McGill [Montréal, Canada], and This work was supported by grant R01-GM134376 to L.B.B., H.P. and J.P.-C., a grant from the Wenner-Gren Foundation to J.F.B. (8702), and the UChicago DDRCC, Center for Interdisciplinary Study of Inflammatory Intestinal Disorders (C-IID) (NIDDK P30 DK042086). The SSHRC Insight Development Grant supported the collection of the Danish samples (430-2017-01193). H.N.P. was supported by an Insight Grant no. 20008499 from the Social Sciences and Humanities Research Council of Canada (SSHRC) and The Canadian Institute for Advanced Research under the Humans and the Microbiome programme. T.P.V. was supported by NIH F32GM140568. X.C. and M. Steinrücken were supported by grant R01GM146051. We also thank the University of Chicago Genomics Facility (RRID:SCR_019196), especially P. Faber, for their assistance with RNA sequencing. H.P. thanks D. Poinar for continued support and manuscript suggestions and editing.
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Yersinia pestis ,General Science & Technology ,Denmark ,Datasets as Topic ,[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity ,Aminopeptidases ,Ancient ,Genetic ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,London ,Genetics ,Humans ,Genetic Predisposition to Disease ,DNA, Ancient ,Selection, Genetic ,Selection ,Plague ,Multidisciplinary ,[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,Prevention ,Immunity ,DNA ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Europe ,Vector-Borne Diseases ,Emerging Infectious Diseases ,Infectious Diseases ,Good Health and Well Being ,[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology ,Infection - Abstract
International audience; Infectious diseases are among the strongest selective pressures driving human evolution1,2. This includes the single greatest mortality event in recorded history, the first outbreak of the second pandemic of plague, commonly called the Black Death, which was caused by the bacterium Yersinia pestis3. This pandemic devastated Afro-Eurasia, killing up to 30-50% of the population4. To identify loci that may have been under selection during the Black Death, we characterized genetic variation around immune-related genes from 206 ancient DNA extracts, stemming from two different European populations before, during and after the Black Death. Immune loci are strongly enriched for highly differentiated sites relative to a set of non-immune loci, suggesting positive selection. We identify 245 variants that are highly differentiated within the London dataset, four of which were replicated in an independent cohort from Denmark, and represent the strongest candidates for positive selection. The selected allele for one of these variants, rs2549794, is associated with the production of a full-length (versus truncated) ERAP2 transcript, variation in cytokine response to Y. pestis and increased ability to control intracellular Y. pestis in macrophages. Finally, we show that protective variants overlap with alleles that are today associated with increased susceptibility to autoimmune diseases, providing empirical evidence for the role played by past pandemics in shaping present-day susceptibility to disease.
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- 2022
235. Preliminary archaeological survey in São Tomé
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Aymeric Nsangou, Jacques, Rocha de Avilez, Gabriel, Wheat, David, and University of Manitoba
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Archaeology ,Surveys ,São Tomé ,Angolares - Abstract
2022 report of the preliminary archaeological survey in São Tomé e Principe
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- 2023
236. Use of a taxon-specific reference database for accurate metagenomics-based pathogen detection of Listeria monocytogenes in turkey deli meat and spinach
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Rumore, Jillian, Walker, Matthew, Pagotto, Franco, Forbes, Jessica D., Peterson, Christy-Lynn, Tyler, Andrea D., Graham, Morag, Van Domselaar, Gary, Nadon, Celine, Reimer, Aleisha, Knox, Natalie, and University of Manitoba
- Subjects
food safety ,classification systems ,pathogens ,food quality - Abstract
Background The reliability of culture-independent pathogen detection in foods using metagenomics is contingent on the quality and composition of the reference database. The inclusion of microbial sequences from a diverse representation of taxonomies in universal reference databases is recommended to maximize classification precision for pathogen detection. However, these sizable databases have high memory requirements that may be out of reach for some users. In this study, we aimed to assess the performance of a foodborne pathogen (FBP)-specific reference database (taxon-specific) relative to a universal reference database (taxon-agnostic). We tested our FBP-specific reference database's performance for detecting Listeria monocytogenes in two complex food matrices—ready-to-eat (RTE) turkey deli meat and prepackaged spinach—using three popular read-based DNA-to-DNA metagenomic classifiers: Centrifuge, Kraken 2 and KrakenUniq. Results In silico host sequence removal led to substantially fewer false positive (FP) classifications and higher classification precision in RTE turkey deli meat datasets using the FBP-specific reference database. No considerable improvement in classification precision was observed following host filtering for prepackaged spinach datasets and was likely a consequence of a higher microbe-to-host sequence ratio. All datasets classified with Centrifuge using the FBP-specific reference database had the lowest classification precision compared to Kraken 2 or KrakenUniq. When a confidence-scoring threshold was applied, a nearly equivalent precision to the universal reference database was achieved for Kraken 2 and KrakenUniq. Recall was high for both reference databases across all datasets and classifiers. Substantially fewer computational resources were required for metagenomics-based detection of L. monocytogenes using the FBP-specific reference database, especially when combined with Kraken 2. Conclusions A universal (taxon-agnostic) reference database is not essential for accurate and reliable metagenomics-based pathogen detection of L. monocytogenes in complex food matrices. Equivalent classification performance can be achieved using a taxon-specific reference database when the appropriate quality control measures, classification software, and analysis parameters are applied. This approach is less computationally demanding and more attainable for the broader scientific and food safety communities.
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- 2023
237. Correction: An examination of the psychosocial consequences experienced by children and adolescents living with congenital heart disease and their primary caregivers: a scoping review protocol
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Dorfman, Tamara L., Archibald, Mandy, Haykowsky, Mark, Scott, Shannon D., and University of Manitoba
- Abstract
Following publication of the original article [1], the authors’ identified errors on the assignment of affiliations. The author group section above shows the correct assignment and the original article (https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-023-02249-7) has been corrected.
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- 2023
238. Health system evaluation in conflict-affected countries: a scoping review of approaches and methods
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Marzouk, Manar, Durrance-Bagale, Anna, Lam, Sze T., Nagashima-Hayashi, Michiko, Ung, Mengieng, Aribou, Zeenathnisa M., Zaseela, Ayshath, Ibrahim, Nafeesah M., Agarwal, Sunanda, Omar, Maryam, Newaz, Sanjida, Mkhallalati, Hala, Howard, Natasha, and University of Manitoba
- Abstract
Introduction Strengthening health systems in conflict-affected settings has become increasingly professionalised. However, evaluation remains challenging and often insufficiently documented in the literature. Many, particularly small-scale health system evaluations, are conducted by government bodies or non-governmental organisations (NGO) with limited capacity to publish their experiences. It is essential to identify the existing literature and main findings as a baseline for future efforts to evaluate the capacity and resilience of conflict-affected health systems. We thus aimed to synthesise the scope of methodological approaches and methods used in the peer-reviewed literature on health system evaluation in conflict-affected settings. Methods We conducted a scoping review using Arksey and O’Malley’s method and synthesised findings using the WHO health system ‘building blocks’ framework. Results We included 58 eligible sources of 2,355 screened, which included examination of health systems or components in 26 conflict-affected countries, primarily South Sudan and Afghanistan (7 sources each), Democratic Republic of the Congo (6), and Palestine (5). Most sources (86%) were led by foreign academic institutes and international donors and focused on health services delivery (78%), with qualitative designs predominating (53%). Theoretical or conceptual grounding was extremely limited and study designs were not generally complex, as many sources (43%) were NGO project evaluations for international donors and relied on simple and lower-cost methods. Sources were also limited in terms of geography (e.g., limited coverage of the Americas region), by component (e.g., preferences for specific components such as service delivery), gendered (e.g., limited participation of women), and colonised (e.g., limited authorship and research leadership from affected countries). Conclusion The evaluation literature in conflict-affected settings remains limited in scope and content, favouring simplified study designs and methods, and including those components and projects implemented or funded internationally. Many identified challenges and limitations (e.g., limited innovation/contextualisation, poor engagement with local actors, gender and language biases) could be mitigated with more rigorous and systematic evaluation approaches.
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- 2023
239. Comparative characterization of Crimean-Congo hemorrhagic fever virus cell culture systems with application to propagation and titration methods
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Li, Hongzhao, Smith, Greg, Goolia, Melissa, Marszal, Peter, Pickering, Bradley S., and University of Manitoba
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Vero E6 ,Titration ,HuH-7 ,Cell culture ,SW-13 ,Cell line ,BSR-T7/5 ,TCID50 ,Crimean-Congo hemorrhagic fever virus ,Plaque assay - Abstract
Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a biosafety level 4 and World Health Organization top priority pathogen. Infection leads to an often fatal hemorrhagic fever disease in humans. The tick-borne virus is endemic in countries across Asia, Europe and Africa, with signs of spreading into new regions. Despite the severity of disease and the potential of CCHFV geographic expansion to cause widespread outbreaks, no approved vaccine or treatment is currently available. Critical for basic research and the development of diagnostics or medical countermeasures, CCHFV viral stocks are commonly produced in Vero E6 and SW-13 cell lines. While a variety of in-house methods are being used across different laboratories, there has been no clear, specific consensus on a standard, optimal system for CCHFV growth and titration. In this study, we perform a systematic, side-by-side characterization of Vero E6 and SW-13 cell lines concerning the replication kinetics of CCHFV under different culture conditions. SW-13 cells are typically cultured in a CO2-free condition (SW-13 CO2−) according to the American Type Culture Collection. However, we identify a CO2-compatible culture condition (SW-13 CO2+) that demonstrates the highest viral load (RNA concentration) and titer (infectious virus concentration) in the culture supernatants, in comparison to SW-13 CO2− and Vero E6 cultures. This optimal viral propagation system also leads to the development of two titration methods: an immunostaining-based plaque assay using a commercial CCHFV antibody and a colorimetric readout, and an antibody staining-free, cytopathic effect-based median tissue culture infectious dose assay using a simple excel calculator. These are anticipated to serve as a basis for a reproducible, standardized and user-friendly platform for CCHFV propagation and titration.
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- 2023
240. Delivering societal impact through supply chain design: insights from B Corps
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Rosca, Eugenia, Taylor, Kelsey, and University of Manitoba
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supply chain management ,B Corporations ,supply chain design ,sustainability - Abstract
Purpose This paper examines how different configurations of societal impact are pursued by purpose-driven organizations (PDOs) and how these configurations align with the application of varying supply chain design (SCD) practices. Design/methodology/approach This multi-method study uses quantitative data from 1588 B Corps and qualitative data from 316 B Corps to examine how PDOs align SCD with the pursuit of diverse types of societal impact. The authors first conduct a cluster analysis to group organizations based on the impact they create. Second, qualitative content analysis connects impact with enabling SCD elements. Findings The analysis of the five identified clusters provides detailed empirical insights on influencers, design decisions and building blocks adopted by PDOs to drive a range of societal impacts. Specifically, the nature of the impact pursued affects (1) whether a PDO will be more influenced by a need in the political environment or an opportunity in the industry environment, (2) the relative importance of the design of social flows versus material flows and (3) the need to develop new relational resources with beneficiaries versus leveraging existing capabilities to manage inter-firm processes. Originality/value This study responds to calls to disaggregate different dimensions of societal impact and examines the relationship between SCD and a breadth of sustainability impacts for different stakeholders. In doing so, the authors identify four SCD pathways organizations can follow to achieve specific societal impacts. This study is also the first to employ a supply chain perspective in the study of certified B Corps.
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- 2023
241. Evaluating the quality of research co-production: Research Quality Plus for Co-Production (RQ + 4 Co-Pro)
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McLean, Robert K. D., Carden, Fred, Aiken, Alice B., Armstrong, Rebecca, Bray, Judy, Cassidy, Christine E., Daub, Olivia, Di Ruggiero, Erica, Fierro, Leslie A., Gagnon, Michelle, Hutchinson, Alison M., Kislov, Roman, Kothari, Anita, Kreindler, Sara, McCutcheon, Chris, Reszel, Jessica, Scarrow, Gayle, Graham, Ian D., and University of Manitoba
- Subjects
research evalution ,community based participatory research ,research co-production ,research quality plus ,research quality plus for co-production ,integrated knowledge translation ,participatory research ,engaged scholarship - Abstract
BackgroundCo-production is an umbrella term used to describe the process of generating knowledge through partnerships between researchers and those who will use or benefit from research. Multiple advantages of research co-production have been hypothesized, and in some cases documented, in both the academic and practice record. However, there are significant gaps in understanding how to evaluate the quality of co-production. This gap in rigorous evaluation undermines the potential of both co-production and co-producers.MethodsThis research tests the relevance and utility of a novel evaluation framework: Research Quality Plus for Co-Production (RQ + 4 Co-Pro). Following a co-production approach ourselves, our team collaborated to develop study objectives, questions, analysis, and results sharing strategies. We used a dyadic field-test design to execute RQ + 4 Co-Pro evaluations amongst 18 independently recruited subject matter experts. We used standardized reporting templates and qualitative interviews to collect data from field-test participants, and thematic assessment and deliberative dialogue for analysis. Main limitations include that field-test participation included only health research projects and health researchers and this will limit perspective included in the study, and, that our own co-production team does not include all potential perspectives that may add value to this work.ResultsThe field test surfaced strong support for the relevance and utility of RQ + 4 Co-Pro as an evaluation approach and framework. Research participants shared opportunities for fine-tuning language and criteria within the prototype version, but also, for alternative uses and users of RQ + 4 Co-Pro. All research participants suggested RQ + 4 Co-Pro offered an opportunity for improving how co-production is evaluated and advanced. This facilitated our revision and publication herein of a field-tested RQ + 4 Co-Pro Framework and Assessment Instrument.ConclusionEvaluation is necessary for understanding and improving co-production, and, for ensuring co-production delivers on its promise of better health.. RQ + 4 Co-Pro provides a practical evaluation approach and framework that we invite co-producers and stewards of co-production—including the funders, publishers, and universities who increasingly encourage socially relevant research—to study, adapt, and apply.
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- 2023
242. Reasonable access: important characteristics and perceived quality of legal and illegal sources of cannabis for medical purposes in Canada
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Capler, N. R., Balneaves, Lynda, Buxton, Jane A., Kerr, Thomas, and University of Manitoba
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drug acquistion ,prescription ,drug safety ,patient perceptions ,medical cannabis - Abstract
Background Throughout the past two decades of legal medical cannabis in Canada, individuals have experienced challenges related to accessing legal sources of cannabis for medical purposes. The objective of our study was to examine the sources of cannabis accessed by individuals authorized to use medical cannabis and to identify possible reasons for their use of illegal sources. Methods Individuals who participated in the Cannabis Access Regulations Study (CANARY), a national cross-sectional survey launched in 2014, and indicated they were currently authorized to use cannabis for medical purposes in Canada were included in this study. We assessed differences between participants accessing cannabis from only legal sources versus from illegal sources in relation to sociodemographic characteristics, health-related factors, and characteristics of medical cannabis they considered important. A secondary analysis assessed differences in satisfaction with various dimensions of cannabis products and services provided by legal versus illegal sources. Results Half of the 237 study participants accessed cannabis from illegal sources. Individuals accessing cannabis from illegal sources were significantly more likely to value pesticide-free products, access to a variety of strains, ability to select strain and dosage, ability to observe and smell cannabis, availability in a dispensary, and availability in small quantities than did individuals accessing cannabis from only legal sources (all p < 0.05). Additionally, participants gave significantly higher satisfaction scores to illegal sources than to legal sources on service-related dimensions of cannabis access (all p < 0.05). Conclusion Our findings contribute to an understanding of reasonable access to medical cannabis from a patient perspective and how to assess whether it has been achieved. Characteristics of cannabis products and services valued by patients and appropriate to their needs should be incorporated into legal medical cannabis programs to promote the use of legal medical sources. While pertaining specifically to medical use of cannabis in Canada, the findings of this study may also be instructive for understanding the use of illegal cannabis sources for non-medical purposes in Canada and provide insight for other jurisdictions implementing cannabis regulations for both medical and non-medical purposes.
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- 2023
243. Going deeper with health equity measurement: how much more can surveys reveal about inequalities in health intervention coverage and mortality in Zambia?
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Blanchard, Andrea K., Jacobs, Choolwe, Musukuma, Mwiche, Chooye, Ovost, Sikapande, Brivine, Michelo, Charles, Boerma, Ties, Wehrmeister, Fernando C., and University of Manitoba
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intervention coverage ,inequality measurement ,RMNCH ,child mortality ,Reproductive, Maternal, Newborn and Child Health ,health equity ,Demographic Health Surveys - Abstract
Background Although Zambia has achieved notable improvements in reproductive, maternal, newborn and child health (RMNCH), continued efforts to address gaps are essential to reach the Sustainable Development Goals by 2030. Research to better uncover who is being most left behind with poor health outcomes is crucial. This study aimed to understand how much more demographic health surveys can reveal about Zambia’s progress in reducing inequalities in under-five mortality rates and RMNCH intervention coverage. Methods Using four nationally-representative Zambia Demographic Health Surveys (2001/2, 2007, 2013/14, 2018), we estimated under-five mortality rates (U5MR) and RMNCH composite coverage indices (CCI) comparing wealth quintiles, urban‐rural residence and provinces. We further used multi-tier measures including wealth deciles and double disaggregation between wealth and region (urban residence, then provinces). These were summarised using slope indices of inequality, weighted mean differences from overall mean, Theil and concentration indices. Results Inequalities in RMNCH coverage and under-five mortality narrowed between wealth groups, residence and provinces over time, but in different ways. Comparing measures of inequalities over time, disaggregation with multiple socio-economic and geographic stratifiers was often valuable and provided additional insights compared to conventional measures. Wealth quintiles were sufficient in revealing mortality inequalities compared to deciles, but comparing CCI by deciles provided more nuance by showing that the poorest 10% were left behind by 2018. Examining wealth in only urban areas helped reveal closing gaps in under-five mortality and CCI between the poorest and richest quintiles. Though challenged by lower precision, wealth gaps appeared to close in every province for both mortality and CCI. Still, inequalities remained higher in provinces with worse outcomes. Conclusions Multi-tier equity measures provided similarly plausible and precise estimates as conventional measures for most comparisons, except mortality among some wealth deciles, and wealth tertiles by province. This suggests that related research could readily use these multi-tier measures to gain deeper insights on inequality patterns for both health coverage and impact indicators, given sufficient samples. Future household survey analyses using fit-for-purpose equity measures are needed to uncover intersecting inequalities and target efforts towards effective coverage that will leave no woman or child behind in Zambia and beyond.
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- 2023
244. Investigating Text Legibility on Non-Rectangular Displays
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Anne Roudaut, Pourang Irani, Marcos Serrano, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), University of Manitoba (CANADA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), University of Bristol (UNITED KINGDOM), Etude de L’Interaction Personne SystèmE (IRIT-ELIPSE), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, University of Bristol [Bristol], University of Manitoba [Winnipeg], and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
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Multimedia ,Computer science ,05 social sciences ,Text legibility ,020207 software engineering ,02 engineering and technology ,Legibility ,computer.software_genre ,Interface homme-machine ,Freeform display ,Human–computer interaction ,Visual design guidelines ,0202 electrical engineering, electronic engineering, information engineering ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,0501 psychology and cognitive sciences ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,Non-rectangular display ,computer ,050107 human factors - Abstract
International audience; Emerging technologies allow for the creation of non-rectangular displays with unlimited constraints in shape. However, the introduction of such displays radically deviates from the prevailing tradition of placing content on rectangular screens and raises fundamental design questions. Among these is the foremost question of how to legibly present text. We address this fundamental concern through a multi-part exploration that includes: (1) a focus-group study from which we collected free-form display scenarios and extracted display shape properties; (2) a framework that identifies different mappings of text onto a non-rectangular shape and formulates hypotheses concerning legibility for different display shape properties; and (3) a series of quantitative text legibility studies to assess our hypotheses. Or results agree with and extend upon other findings in the existing literature on text legibility, but they also uncover unique instances in which different rules need to be applied for non-rectangular displays. These results also provide guidelines for the design of visual interfaces.
- Published
- 2016
245. Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs
- Author
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Odile Duvaux, Andrea Perota, Hélène Perreault, Elsa Lheriteau, Bernard Martinet, Irina Lagutina, Gwénaëlle Evanno, Ludmilla Le Berre, Hervé Raoul, Olivier Reynard, Cesare Galli, Giovanna Lazzari, Apolline Salama, Frédéric Jacquot, Roberto Duchi, Sophie Conchon, Jean-Paul Judor, Viktor E. Volchkov, Jean-Marie Bach, Jean-Paul Soulillou, Hoa Le Mai, Bases moléculaires de la pathogénicité virale – Molecular Basis of Viral Pathogenicity (BMPV), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire P4 - Jean Mérieux, Centre Européen de Virologie/Immunologie-Institut National de la Santé et de la Recherche Médicale (INSERM), Xenothera [Nantes, France], Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Avantea Laboratory of Reproductive Technologies [Cremona, Italy], University of Manitoba [Winnipeg], Anti-EBOV GP IgGs Lacking alpha 1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs, Reynard, Olivier, Jacquot, Frédéric, Evanno, Gwénaëlle, Mai, Hoa Le, Salama, Apolline, Martinet, Bernard, Duvaux, Odile, Bach, Jean-Marie, Conchon, Sophie, Judor, Jean-Paul, Perota, Andrea, Lagutina, Irina, Duchi, Roberto, Lazzari, Giovanna, Le Berre, Ludmilla, Perreault, Hélène, Lheriteau, Elsa, Raoul, Hervé, Volchkov, Viktor, Galli, Cesare, Soulillou, Jean-Paul, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Davoine, Laure-Hélène, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bases moléculaires de la pathogénicité virale – Molecular Basis of Viral Pathogenicity, Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes, University of Manitoba, and University of Bologna
- Subjects
0301 basic medicine ,Male ,Physiology ,Swine ,lcsh:Medicine ,medicine.disease_cause ,Antibodies, Viral ,Biochemistry ,Epitope ,Immunoglobulin G ,0302 clinical medicine ,Viral Envelope Proteins ,Pig Models ,Intraperitoneal Injections ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Immune Physiology ,Medicine and Health Sciences ,030212 general & internal medicine ,Viral ,Enzyme-Linked Immunoassays ,lcsh:Science ,Routes of Administration ,Mammals ,Multidisciplinary ,Immune System Proteins ,Immunogenicity ,Vaccination ,Agriculture ,Animal Models ,Hematology ,Viral Load ,Ebolavirus ,3. Good health ,Antibodies, Anti-Idiotypic ,Body Fluids ,Titer ,Blood ,Anti-Idiotypic ,Vertebrates ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Ebola ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Antibody ,Anatomy ,[SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy ,Viral load ,Research Article ,EBOV ,Livestock ,Immunology ,Guinea Pigs ,α1-3-Galactose ,Biology ,rabbit antithymocyte globulin ,hemorrhagic-fever ,virus-infection ,nonhuman-primates ,sialic-acid ,molecular characterization ,monoclonal-antibody ,immunoglobulin-g ,disease ,immunotherapy ,Research and Analysis Methods ,Rodents ,Virus ,Antibodies ,03 medical and health sciences ,Model Organisms ,medicine ,Animals ,Antigens ,Ebola Vaccines ,Immunoassays ,Pharmacology ,Ebola virus ,lcsh:R ,Organisms ,Biology and Life Sciences ,Proteins ,Galactose ,Anti-EBOV ,[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy ,Hemorrhagic Fever, Ebola ,Guinea pig ,Virology ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,030104 developmental biology ,Amniotes ,biology.protein ,Immunologic Techniques ,Hemorrhagic Fever ,lcsh:Q ,Neuraminic Acids - Abstract
International audience; Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever. IgG glycans display powerful xenogeneic antigens in humans, for example α1-3 Galactose and the glycolyl form of neuraminic acid Neu5Gc, and IgGs deprived of these key sugar epitopes may represent an advantage for passive immunotherapy. In this paper, we explored whether low immunogenicity IgGs had a protective effect on a guinea pig model of Ebola virus (EBOV) infection. For this purpose, a double knock-out pig lacking α1-3 Galactose and Neu5Gc was immunized against virus-like particles displaying surface EBOV glycoprotein GP. Following purification from serum, hyper-immune polyclonal IgGs were obtained, exhibiting an anti-EBOV GP titer of 1:100,000 and a virus neutralizing titer of 1:100. Guinea pigs were injected intramuscularly with purified IgGs on day 0 and day 3 post-EBOV infection. Compared to control animals treated with IgGs from non-immunized double KO pigs, the anti-EBOV IgGs-treated animals exhibited a significantly prolonged survival and a decreased virus load in blood on day 3. The data obtained indicated that IgGs lacking α1-3 Galactose and Neu5Gc, two highly immunogenic epitopes in humans, have a protective effect upon EBOV infection.
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- 2016
246. Genetic diversity of feral alfalfa (Medicago sativa L.) populations occurring in Manitoba, Canada and comparison with alfalfa cultivars: an analysis using SSR markers and phenotypic traits
- Author
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P. Barre, Robert H. Gulden, R. C. Van Acker, Bernadette Julier, Muthukumar V. Bagavathiannan, University of Manitoba, University of Manitoba [Winnipeg], Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères (P3F), Institut National de la Recherche Agronomique (INRA), Department of Plant Agriculture, and University of Guelph
- Subjects
SELECTION ,[SDV.SA]Life Sciences [q-bio]/Agricultural sciences ,0106 biological sciences ,Germplasm ,NOVEL TRAIT CONFINEMENT ,animal diseases ,Population ,Zoology ,Plant Science ,Horticulture ,Biology ,SSR MARKERS ,01 natural sciences ,Analysis of molecular variance ,03 medical and health sciences ,Genetic variation ,Genetics ,FERAL ALFALFA ,Medicago sativa ,education ,030304 developmental biology ,2. Zero hunger ,0303 health sciences ,education.field_of_study ,Genetic diversity ,Natural selection ,Ecology ,PHENOTYPIC TRAITS ,fungi ,food and beverages ,Phenotypic trait ,MANITOBA ,GENETIC DIVERSITY ,Agronomy and Crop Science ,010606 plant biology & botany - Abstract
Feral populations of cultivated crops may act as reservoirs for novel traits and aid in trait movement across the landscape. Knowledge on the genetic diversity of feral populations may provide new insights into their origin and evolution and may help in the design of efficient novel trait confinement protocols. In this study, the genetic diversity of 12 feral alfalfa (Medicago sativa) populations originating from southern Manitoba (Canada) and 10 alfalfa cultivars and a M. falcata germplasm were investigated using eight SSR markers (i.e., microsatellites) and 14 phenotypic traits. We found that the genetic diversity observed in feral populations was similar to the diversity detected among the 10 cultivars. Analysis of molecular variance revealed that there was great genetic variation within (99.8%) rather than between different feral populations. Cluster analysis (unweighted pair-group method using arithmetic average) revealed no differentiation between feral populations and cultivars for neutral loci. High levels of population differentiation for phenotypic traits (and not for neutral markers) suggest the occurrence of heterogeneous selection for adaptive traits. The phenotypic traits we studied did not distinctly separate feral populations from cultivars but there was evidence of natural selection in feral populations for traits including winter survivability, rhizome production, and prostrate growth habit. Our results suggest that feral alfalfa populations need to be considered in the risk assessment of alfalfa containing novel genetically modified (GM) traits. Further, feral alfalfa populations may be regarded as a source of new germplasm for plant improvement.
- Published
- 2010
247. Workers Compensation Board: Rotator Cuff Tear Management
- Author
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University of Alberta and Dr. Peter MacDonald, Pan Am Clinic Medical Director and University of Manitoba Faculty of Medicine Professor
- Published
- 2011
248. Effects of Targeting Lower Arterial Oxygen Saturations on the Development of Control of Breathing in Very Preterm Infants
- Author
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Ruben E. Alvaro, Associate Professor of Pediatrics, University of Manitoba
- Published
- 2011
249. Greater Combined Reductions of HbA1c ≥ 1.0% and Body Weight Loss ≥ 5.0% or ≥ 10.0% with Orally Administered Semaglutide Versus Comparators
- Author
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Kathleen M. Dungan, Lars Bardtrum, Erik Christiansen, Johanna Eliasson, Linda Mellbin, Vincent C. Woo, Tina Vilsbøll, and University of Manitoba
- Subjects
Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Introduction A post hoc analysis of the PIONEER 1–5 and 8 trials assessed the clinically relevant composite endpoints of HbA1c (glycated haemoglobin) reduction ≥ 1% and body weight loss of ≥ 5% or ≥ 10% with orally administered semaglutide versus comparators. Methods In the PIONEER trials, people with type 2 diabetes were randomised to orally administered semaglutide versus placebo (PIONEER 1, 4, 5 and 8), empagliflozin (PIONEER 2), sitagliptin (PIONEER 3) and liraglutide (PIONEER 4) for 26–78 weeks. This analysis assessed the proportion of people achieving an HbA1c reduction of ≥ 1% and body weight loss of ≥ 5% at week 26 and at end of treatment, and the proportion of people achieving an HbA1c reduction of ≥ 1% and body weight loss of ≥ 10% at end of treatment. Results Overall, 3506 people in PIONEER 1–5 and 8 were included. At week 26 and at end of treatment, odds of achieving the composite endpoint of an HbA1c reduction of ≥ 1% and body weight loss of ≥ 5% were significantly greater with orally administered semaglutide 14 mg than with placebo (PIONEER 1, 4, 5 and 8; all p
- Published
- 2023
250. Temporal relationship between vasopressor and sedative administration and cerebrovascular response in traumatic brain injury: a time-series analysis
- Author
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Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Izabella Marquez, Fiorella Amenta, Kevin Y. Stein, Frederick A. Zeiler, Froese, Logan [0000-0002-6076-0189], Gomez, Alwyn [0000-0002-3737-2065], Sainbhi, Amanjyot Singh [0000-0003-3231-5683], Vakitbilir, Nuray [0000-0003-2764-145X], Stein, Kevin Y [0000-0002-5983-008X], Zeiler, Frederick A [0000-0003-1737-0510], Apollo - University of Cambridge Repository, and University of Manitoba
- Subjects
Vasopressors ,Cerebrovascular Reactivity ,Autoregulation ,Critical Care and Intensive Care Medicine ,Sedative Drugs - Abstract
Background Although vasopressor and sedative agents are commonly used within the intensive care unit to mediate systemic and cerebral physiology, the full impact such agents have on cerebrovascular reactivity remains unclear. Using a prospectively maintained database of high-resolution critical care and physiology, the time-series relationship between vasopressor/sedative administration, and cerebrovascular reactivity was interrogated. Cerebrovascular reactivity was assessed through intracranial pressure and near infrared spectroscopy measures. Using these derived measures, the relationship between hourly dose of medication and hourly index values could be evaluated. The individual medication dose change and their corresponding physiological response was compared. Given the high number of doses of propofol and norepinephrine, a latent profile analysis was used to identify any underlying demographic or variable relationships. Finally, using time-series methodologies of Granger causality and vector impulse response functions, the relationships between the cerebrovascular reactivity derived variables were compared. Results From this retrospective observational study of 103 TBI patients, the evaluation between the changes in vasopressor or sedative agent dosing and the previously described cerebral physiologies was completed. The assessment of the physiology pre/post infusion agent change resulted in similar overall values (Wilcoxon signed-ranked p value > 0.05). Time series methodologies demonstrated that the basic physiological relationships were identical before and after an infusion agent was changed (Granger causality demonstrated the same directional impact in over 95% of the moments, with response function being graphically identical). Conclusions This study suggests that overall, there was a limited association between the changes in vasopressor or sedative agent dosing and the previously described cerebral physiologies including that of cerebrovascular reactivity. Thus, current regimens of administered sedative and vasopressor agents appear to have little to no impact on cerebrovascular reactivity in TBI.
- Published
- 2023
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