Search

Your search keyword '"Tybjærg-Hansen, A"' showing total 3,380 results
Start Over Author "Tybjærg-Hansen, A"
3,380 results on '"Tybjærg-Hansen, A"'

201. Rare and low-frequency coding variants alter human adult height

Author

Marouli, Eirini, Graff, Mariaelisa, Medina-Gomez, Carolina, Lo, Ken Sin, Wood, Andrew R., Kjaer, Troels R., Fine, Rebecca S., Lu, Yingchang, Schurmann, Claudia, Highland, Heather M., Rüeger, Sina, Thorleifsson, Gudmar, Justice, Anne E., Lamparter, David, Stirrups, Kathleen E., Turcot, Valérie, Young, Kristin L., Winkler, Thomas W., Esko, Tõnu, Karaderi, Tugce, Locke, Adam E., Masca, Nicholas G. D., Ng, Maggie C. Y., Mudgal, Poorva, Rivas, Manuel A., Vedantam, Sailaja, Mahajan, Anubha, Guo, Xiuqing, Abecasis, Goncalo, Aben, Katja K., Adair, Linda S., Alam, Dewan S., Albrecht, Eva, Allin, Kristine H., Allison, Matthew, Amouyel, Philippe, Appel, Emil V., Arveiler, Dominique, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Banas, Bernhard, Bang, Lia E., Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bonnycastle, Lori L., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Burt, Amber A., Butterworth, Adam S., Carey, David J., Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Cuellar-Partida, Gabriel, Danesh, John, Davies, Gail, de Bakker, Paul I. W., de Borst, Gert J., de Denus, Simon, de Groot, Mark C. H., de Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., den Hollander, Anneke I., Dennis, Joe G., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dunning, Alison M., Easton, Douglas F., Ebeling, Tapani, Edwards, Todd L., Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Faul, Jessica D., Feitosa, Mary F., Feng, Shuang, Ferrannini, Ele, Ferrario, Marco M., Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franks, Paul W., Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Giri, Ayush, Girotto, Giorgia, Gordon, Scott D., Gordon-Larsen, Penny, Gorski, Mathias, Grarup, Niels, Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Hayward, Caroline, He, Liang, Heid, Iris M., Heikkilä, Kauko, Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Hocking, Lynne J., Hollensted, Mette, Holmen, Oddgeir L., Hovingh, Kees G., Howson, Joanna M. M., Hoyng, Carel B., Huang, Paul L., Hveem, Kristian, Ikram, Arfan M., Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jhun, Min A., Jia, Yucheng, Jiang, Xuejuan, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jousilahti, Pekka, Jukema, Wouter J., Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Keeman, Renske, Kiemeney, Lambertus A., Kitajima, Hidetoshi, Kluivers, Kirsten B., Kocher, Thomas, Komulainen, Pirjo, Kontto, Jukka, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kriebel, Jennifer, Kuivaniemi, Helena, Küry, Sébastien, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lakka, Timo A., Lange, Ethan M., Lange, Leslie A., Langefeld, Carl D., Langenberg, Claudia, Larson, Eric B., Lee, I-Te, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Yeheng, Liu, Yongmei, Lophatananon, Artitaya, Luan, Jianʼan, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Mackey, David A., Madden, Pamela A. F., Manning, Alisa K., Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Martin, Nicholas G., Mazul, Angela L., Meidtner, Karina, Metspalu, Andres, Mitchell, Paul, Mohlke, Karen L., Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Nauck, Matthias, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Ntalla, Ioanna, OʼConnel, Jeffrey R., Oksa, Heikki, Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Person, Thomas N., Pirie, Ailith, Polasek, Ozren, Posthuma, Danielle, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Renström, Frida, Ridker, Paul M., Rioux, John D., Robertson, Neil, Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sandow, Kevin, Sapkota, Yadav, Sattar, Naveed, Schmidt, Marjanka K., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati, Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S., Smith, Albert Vernon, Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Steinthorsdottir, Valgerdur, Stringham, Heather M., Stumvoll, Michael, Surendran, Praveen, Hart, Leen M.ʼt, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Ulivi, Sheila, van der Laan, Sander W., Van Der Leij, Andries R., van Duijn, Cornelia M., van Schoor, Natasja M., van Setten, Jessica, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vozzi, Diego, Walker, Mark, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Wareham, Nicholas J., Warren, Helen R., Wessel, Jennifer, Willems, Sara M., Wilson, James G., Witte, Daniel R., Woods, Michael O., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Rotter, Jerome I, Boehnke, Michael, Kathiresan, Sekar, McCarthy, Mark I., Willer, Cristen J., Stefansson, Kari, Borecki, Ingrid B., Liu, Dajiang J., North, Kari E., Heard-Costa, Nancy L., Pers, Tune H., Lindgren, Cecilia M., Oxvig, Claus, Kutalik, Zoltán, Rivadeneira, Fernando, Loos, Ruth J. F., Frayling, Timothy M., Hirschhorn, Joel N., Deloukas, Panos, and Lettre, Guillaume

Published
2017
Full Text
View/download PDF

203. Associations of Alzheimer Disease–Protective APOE Variants With Age-Related Macular Degeneration

Author

Katrine L, Rasmussen, Anne, Tybjærg-Hansen, Børge G, Nordestgaard, and Ruth, Frikke-Schmidt

Subjects
Ophthalmology
Abstract

ImportanceThe association of major lipid genes with and their potential as drug targets for age-related macular degeneration (AMD) is unknown. These associations are important to study because AMD is the leading cause of irreversible late-onset blindness in high-income countries.ObjectiveTo determine whether the full range of structural genetic variation in apolipoprotein E (APOE), a master gene in peripheral and cerebral lipid metabolism, is associated with risk of AMD.Design, Setting, and ParticipantsThis cohort study used data from the Copenhagen City Heart Study (CCHS) and the Copenhagen General Population Study (CGPS) cohorts. Participants were followed from study inclusion at the time of blood sampling to occurrence of event, death, emigration, or December 7, 2018, whichever came first. For participants in CCHS, the APOE gene was sequenced, and 9 variants with a heterozygote frequency of at least 0.0002 were genotyped in the CGPS. Observers were masked to patient groupings. Data were analyzed from March to September 2021.ExposuresThe exposure was APOE status, and the direct gene product in plasma, apoE levels, was measured in all participants.Main Outcomes and MeasuresCox regression was applied to estimate risk of AMD associated with APOE genotype.ResultsA total of 105 546 participants (mean [SD] age, 57.7 [13.4] years; 58 140 [55%] female participants) were included. Compared with participants with the common ɛ33 genotype, risk of AMD was lower in participants with ε44 (multifactorially adjusted hazard ratio [aHR], 0.66; 95% CI, 0.45-0.96) and ε43 (aHR, 0.80; 95% CI, 0.71-0.90) genotypes and higher in the ε32 (aHR, 1.15; 95% CI, 1.00-1.31) genotype. Compared with noncarriers, risk of AMD was higher for participants with Gly145Asp (aHR, 3.53; 95% CI, 1.14-10.96) and Arg154Cys (aHR, 4.52; 95% CI, 1-13-18.13) heterozygotes. Results were similar after further adjustment for lipid traits and after adjustment for the APOE ε2/ε3/ε4 variant. Combining all common and rare structural variants in a weighted allele score, risk of AMD per 1-mg/dL genetically higher plasma apoE was increased in the adjusted model (aHR, 1.12; 95% CI, 1.05-1.19), the adjusted model plus APOE ɛ2/ɛ3/ɛ4 status (aHR, 1.82; 95% CI, 1.20-2.76), and the adjusted model in individuals with the ε33 genotype only (aHR, 1.77; 95% CI, 1.14-2.75).Conclusions and RelevanceThese findings highlight that structural variation in APOE beyond the ε2/ε3/ε4 variants may be important for risk of AMD in a population of European ancestry. Rare functional ɛ2-like variants in APOE have previously been reported to have protective associations for Alzheimer disease but the present findings suggest a simultaneous high risk of AMD. This would limit the drug target potential of mechanisms resembling these variants.

Published
2023
Full Text
View/download PDF

206. Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

Author

Cuchel, Marina, Bruckert, Eric, Ginsberg, Henry N., Raal, Frederick J., Santos, Raul D., Hegele, Robert A., Kuivenhoven, Jan Albert, Nordestgaard, Børge G., Descamps, Olivier S., Steinhagen-Thiessen, Elisabeth, Tybjærg-Hansen, Anne, Watts, Gerald F., Averna, Maurizio, Boileau, Catherine, Borén, Jan, Catapano, Alberico L., Defesche, Joep C., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Masana, Luis, Pajukanta, Päivi, Parhofer, Klaus G., Ray, Kausik K., Stalenhoef, Anton F. H., Stroes, Erik, Taskinen, Marja-Riitta, Wiegman, Albert, Wiklund, Olov, Chapman, M. John, Cuchel, Marina, Bruckert, Eric, Chapman, M. John, Descamps, Olivier S., Ginsberg, Henry N., Hegele, Robert A., Kuivenhoven, Jan Albert, Nordestgaard, Børge G., Raal, Frederick J., Santos, Raul D., Steinhagen-Thiessen, Elisabeth, Tybjærg-Hansen, Anne, Watts, Gerald F., Chapman, M. John, Ginsberg, Henry N., Averna, Maurizio, Boileau, Catherine, Borén, Jan, Catapano, Alberico L., Defesche, Joep C., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Masana, Luis, Pajukanta, Päivi, Parhofer, Klaus G., Ray, Kausik K., Stalenhoef, Anton F. H., Stroes, Erik, Taskinen, Marja-Riitta, Wiegman, Albert, and Wiklund, Olov

Published
2014
Full Text
View/download PDF

210. HEART DISEASE: Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

Author

Zanoni, Paolo, Khetarpal, Sumeet A., Larach, Daniel B., Hancock-Cerutti, William F., Millar, John S., Cuchel, Marina, DerOhannessian, Stephanie, Kontush, Anatol, Surendran, Praveen, Saleheen, Danish, Trompet, Stella, Jukema, Wouter J., De Craen, Anton, Deloukas, Panos, Sattar, Naveed, Ford, Ian, Packard, Chris, al Shafi Majumder, Abdullah, Alam, Dewan S., Di Angelantonio, Emanuele, Abecasis, Goncalo, Chowdhury, Rajiv, Erdmann, Jeanette, Nordestgaard, Børge G., Nielsen, Sune F., Tybjærg-Hansen, Anne, Schmidt, Ruth Frikke, Kuulasmaa, Kari, Liu, Dajiang J., Perola, Markus, Blankenberg, Stefan, Salomaa, Veikko, Männistö, Satu, Amouyel, Philippe, Arveiler, Dominique, Ferrieres, Jean, Müller-Nurasyid, Martina, Ferrario, Marco, Kee, Frank, Willer, Cristen J., Samani, Nilesh, Schunkert, Heribert, Butterworth, Adam S., Howson, Joanna M.M., Peloso, Gina M., Stitziel, Nathan O., Danesh, John, Kathiresan, Sekar, and Rader, Daniel J.

Published
2016
Full Text
View/download PDF

212. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population

Author

Maria C. Stene, Ruth Frikke-Schmidt, Børge G. Nordestgaard, and Anne Tybjærg-Hansen

Subjects
apolipoproteins, genetic epidemiology, large-scale genotyping, lipids, lipoproteins, molecular biology, Biochemistry, QD415-436
Abstract

Zinc Finger Protein 202 (ZNF202) is a transcriptional repressor that binds elements found predominantly in genes involved in HDL metabolism. We tested the following hypotheses: 1) frequencies of single-nucleotide polymorphisms (SNPs) and haplotypes in ZNF202 differ between individuals with low and high HDL cholesterol; and 2) SNPs in ZNF202 affect HDL cholesterol levels in the general population. We screened the promoter and protein-coding exons of ZNF202 in individuals with the highest 1% (n = 95) and lowest 1% (n = 95) HDL cholesterol among 9,259 Danish adults. None of the 10 SNPs identified differed in frequency as single sites or as haplotypes between low and high HDL cholesterol groups. In accordance with this, seven mutations were equally frequent (4–5%) in individuals with low or high HDL cholesterol. Finally, for all five SNPs identified in the coding region, we determined the association of genotype with HDL cholesterol in 9,259 individuals from the general population. Four SNPs were not associated with variation in HDL cholesterol, although c.*2T>G homozygosity was associated with a discrete effect on HDL cholesterol in men. We show that genetic variation in ZNF202 is common in the general population. However, SNPs in the protein-coding region of ZNF202 do not make a major contribution to HDL cholesterol levels.

Published
2006
Full Text
View/download PDF

213. Contribution of regulatory and structural variations in APOE to predicting dyslipidemia

Author

Jari H. Stengård, Sharon L.R. Kardia, Sara C. Hamon, Ruth Frikke-Schmidt, Anne Tybjærg-Hansen, Veikko Salomaa, Eric Boerwinkle, and Charles F. Sing

Subjects
apolipoprotein E gene, pleiotropy, data mining, regulation, lipids, Biochemistry, QD415-436
Abstract

The objective of this study was to evaluate 1) whether non single nucleotide polymorphisms-coding (non-cSNP) in the apolipoprotein E gene (APOE) identified by resequencing studies contribute to statistically explaining dyslipidemia if variations in the two cSNPs in exon 4 that define the ϵ2, ϵ3, and ϵ4 alleles are ignored, and 2) whether the contribution of these additional SNPs persists when variations in the cSNPs are considered. We used an ecological, multiple-population, data-mining strategy to identify single-SNP and two-SNP genotypes that distinguish between high and low levels of plasma lipids in three training samples, European-Americans from Rochester, MN, African-Americans from Jackson, MS, and Europeans from North Karelia, Finland. We found that a pair of SNPs located in the 5′ region define genotypes A560T832/A560T832, A560T832/A560G832, and A560T832/T560T832, which distinguish between high and low levels of HDL-cholesterol (HDL-C), triglycerides (TG), and/or total cholesterol (T-C). The A560T832/- genotypes predicted high TG and high T-C in both genders in a large independent test sample from Copenhagen, Denmark. Prediction of high T-C in the Danish females was dependent on genotypes defined by the cSNPs. Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large.

Published
2006
Full Text
View/download PDF

220. Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome

Author

Zanoni, Paolo, primary, Panteloglou, Grigorios, additional, Othman, Alaa, additional, Haas, Joel T., additional, Meier, Roger, additional, Rimbert, Antoine, additional, Futema, Marta, additional, Abou Khalil, Yara, additional, Norrelykke, Simon F., additional, Rzepiela, Andrzej J., additional, Stoma, Szymon, additional, Stebler, Michael, additional, van Dijk, Freerk, additional, Wijers, Melinde, additional, Wolters, Justina C., additional, Dalila, Nawar, additional, Huijkman, Nicolette C. A., additional, Smit, Marieke, additional, Gallo, Antonio, additional, Carreau, Valérie, additional, Philippi, Anne, additional, Rabès, Jean-Pierre, additional, Boileau, Catherine, additional, Visentin, Michele, additional, Vonghia, Luisa, additional, Weyler, Jonas, additional, Francque, Sven, additional, Verrijken, An, additional, Verhaegen, Ann, additional, Van Gaal, Luc, additional, van der Graaf, Adriaan, additional, van Rosmalen, Belle V., additional, Robert, Jerome, additional, Velagapudi, Srividya, additional, Yalcinkaya, Mustafa, additional, Keel, Michaela, additional, Radosavljevic, Silvija, additional, Geier, Andreas, additional, Tybjaerg-Hansen, Anne, additional, Varret, Mathilde, additional, Rohrer, Lucia, additional, Humphries, Steve E., additional, Staels, Bart, additional, van de Sluis, Bart, additional, Kuivenhoven, Jan Albert, additional, and von Eckardstein, Arnold, additional

Published
2022
Full Text
View/download PDF

221. Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Debette, Stéphanie, primary, Mishra, Aniket, additional, Malik, Rainer, additional, Hachiya, Tsuyoshi, additional, Jürgenson, Tuuli, additional, Namba, Shinichi, additional, Koido, Masaru, additional, Grand, Quentin Le, additional, Kamanu, Frederick, additional, Shi, Mingyang, additional, He, Yunye, additional, Georgakis, Marios, additional, Caro, Ilana, additional, Krebs, Kristi, additional, Vaura, Felix, additional, Habib, Naomi, additional, Winsvold, Bendik, additional, Jee, Yon Ho, additional, Thomassen, Jesper Qvist, additional, Abedi, Vida, additional, Cárcel-Márquez, Jara, additional, Lin, Kuang, additional, Nygaard, Marianne, additional, Chauhan, Ganesh, additional, Leonard, Hampton, additional, Yang, Chaojie, additional, Yonova-Doing, Ekaterina, additional, Knol, Maria, additional, Ago, Tetsuro, additional, Amouyel, Philippe, additional, Anderson, Christopher, additional, Armstrong, Nicole, additional, Bakker, Mark, additional, Bartz, Traci, additional, Bis, Joshua, additional, Bordes, Constance, additional, Borte, Sigrid, additional, Cain, Anael, additional, Ridker, Paul, additional, Chen, Zhengming, additional, Chong, Michael, additional, Cole, John, additional, de Cid, Rafael, additional, Endres, Matthias, additional, Ferreira, Leslie, additional, Gasca, Natalie, additional, Gudnason, Vilmundur, additional, Hata, Jun, additional, Havulinna, Aki, additional, Hopewell, Jemma, additional, Hyacinth, Hyacinth, additional, Inouye, Michael, additional, Jacob, Mina, additional, Jeon, Christina , additional, Jern, Christina, additional, Kamouchi, Masahiro, additional, Keene, Keith, additional, Kitazono, Takanari, additional, Kittner, Steven, additional, Konuma, Takahiro, additional, Kumar, Amit, additional, Lacaze, Paul, additional, Launer, Lenore, additional, Lepik, Kaido, additional, Li, Jiang, additional, Li, Liming, additional, Manichaikul, Ani, additional, Markus, Hugh, additional, Marston, Nicholas, additional, Meitinger, Thomas, additional, Mitchell, Braxton, additional, Montellano, Felipe, additional, Morisaki, Takayuki, additional, Mosley, Thomas, additional, Nalls, Mike, additional, Nordestgaard, Børge, additional, O'Donnell, Martin, additional, Okada, Yukinori, additional, Pare, Guillaume, additional, Peters, Annette, additional, Psaty, Bruce, additional, Rich, Stephen, additional, Rosand, Jonathan, additional, Sabatine, Marc, additional, Sacco, Ralph, additional, Saleheen, Danish, additional, Sandset, Else Charlotte, additional, Sargurupremraj, Muralidharan, additional, Sasaki, Makoto, additional, Satizabal, Claudia, additional, Schmidt, Carsten, additional, Shimizu, Atsushi, additional, Smith, Nicholas, additional, Strbian, Daniel, additional, Sutoh, Yoichi, additional, Tanno, Kozo, additional, Tiedt, Steffen, additional, Torres-Aguila, Nuria, additional, Trégouët, David-Alexandre, additional, Trompet, Stella, additional, Tuladhar, Anil, additional, Tybjærg-Hansen, Anne, additional, Vugt, Marion van, additional, Vibo, Riina, additional, Wiggins, Kerri, additional, Woo, Daniel, additional, Xu, Huichun, additional, Yang, Qiong, additional, Lathrop, Mark, additional, Millwood, Iona, additional, Gieger, Christian, additional, Ninomiya, Toshiharu, additional, Grabe, Hans, additional, Jukema, J Wouter, additional, Rissanen, Ina, additional, Seshadri, Sudha, additional, Longstreth, William, additional, Chasman, Daniel, additional, Howson, Joanna, additional, Irvin, Marguerite, additional, Adams, Hieab, additional, Wasssertheil-Smoller, Sylvia, additional, Christensen, Kaare, additional, Ikram, M. Arfan, additional, Rundek, Tatjana, additional, Rotter, Jerome, additional, Riaz, Moeen, additional, Simonsick, Eleanor, additional, Kõrv, Janika, additional, França, Paulo, additional, Fornage, Myriam, additional, Zand, Ramin, additional, Prasad, Kameshwar, additional, Frikke-Schmidt, Ruth, additional, de Leeuw, Frank-Erik, additional, Liman, Thomas, additional, Haeusler, Karl Georg, additional, Ruigrok, Ynte, additional, Heuschmann, Peter, additional, Jung, Keum, additional, Zwart, John-Anker, additional, Niiranen, Teemu, additional, Ruff, Christian, additional, Fernández-Cadenas, Israel, additional, Walters, Robin, additional, Milani, Lili, additional, Kamatani, Yoichiro, additional, and Dichgans, Martin, additional

Published
2022
Full Text
View/download PDF

224. Abstract 10469: Cardiometabolic Risk Factors as Causal Mediators of the Relationship Between High Body Mass Index and Chronic Kidney Disease: A Two-Step Mendelian Randomization Study and Mediation Analyses

Author

Frida Emanuelsson, Kaitlin Wade, Anette Varbo, Anne Tybjaerg-hansen, George Davey Smith, Borge G Nordestgaard, Marianne Benn, and Nicholas Timpson

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: Observational studies suggest that obesity is a risk factor of chronic kidney disease (CKD). It is unclear whether this reflects a direct causal effect of obesity or an effect mediated by obesity-related metabolic changes. Hypotheses: We hypothesised that 1) obesity is a causal risk factor of CKD defined as eGFR 2 and 2) this causal effect is mediated through changes in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterols, triglycerides, glucose, blood pressure and C-reactive protein (CRP) levels. Methods: To assess causality and investigate mediation, we used a combination of observational, two-step Mendelian randomization, and mediation analyses on individual-level data from two cohorts of the Danish general population (N=117,213). Results: Observationally, higher BMI was associated with a lower eGFR (change in eGFR; -0.81, confidence interval [CI]: -0.89- -0.73)) and a higher risk of CKD (odds ratio [OR]:1.19; 95% CI: 1.16-1.22) per 5kg/m 2 higher BMI (p for trend for both -40 ). Mendelian randomization analyses supported a causal effect of higher BMI on lower eGFR (change in eGFR -17.3 mL/min/1.73m 2 (95%CI: -19.3- -15.3), and risk of CKD (risk ratio [RR]6.99 (95%CI: 1.63-30.1) per 5kg/m 2 higher BMI. Measured BMI and the BMI allele score used in Mendelian randomization analyses were associated with changes in levels of LDL and HDL cholesterols, triglycerides, glucose, blood pressure, and CRP. Observational and Mendelian randomization analyses showed evidence to support a causal effect of changes in levels of systolic and diastolic blood pressure, LDL cholesterol and CRP with lower eGFR and higher risk of CKD. Of the excess risk of CKD coming from high BMI, elevated systolic and diastolic blood pressure mediated 18%(95%CI:14-22) and 9% (7-11), respectively. 9% (95%CI: 8-12) was mediated by elevated LDL cholesterol and 29% (95%CI: 23-35) by elevated CRP. Conclusion: Triangulating evidence from observational and Mendelian randomization analyses provided evidence to support a causal role of obesity on the risk of CKD and that this causal effect may be partly mediated by elevated systolic and diastolic blood pressure, CRP and LDL cholesterol levels.

Published
2021
Full Text
View/download PDF

225. C-reactive protein levels and risk of dementia-Observational and genetic studies of 111,242 individuals from the general population

Author

Sharif H. Hegazy, Jesper Qvist Thomassen, Ida Juul Rasmussen, Børge G. Nordestgaard, Anne Tybjærg‐Hansen, and Ruth Frikke‐Schmidt

Subjects
Epidemiology, Health Policy, Body Mass Index, Psychiatry and Mental health, Cellular and Molecular Neuroscience, C-Reactive Protein, Developmental Neuroscience, Alzheimer Disease, Risk Factors, Humans, Neurology (clinical), Prospective Studies, Geriatrics and Gerontology, Proportional Hazards Models
Abstract

Introduction: Increased plasma levels of C-reactive protein (CRP) in midlife are associated with increased risk of Alzheimer's disease (AD), whereas in older age the opposite association is observed. Whether genetically determined CRP is associated with AD remains unclear. Methods: A total of 111,242 White individuals from the Copenhagen General Population Study and the Copenhagen City Heart Study were included. Plasma levels of CRP and four regulatory genetic variants in the CRP gene were determined. Results: For CRP percentile group 1 to 5 (lowest plasma CRP) versus the 50 to 75 group (reference), the hazard ratio for AD was 1.69 (95% confidence interval 1.29–2.16). Genetically low CRP was associated with increased risk of AD in individuals with body mass index ≤25 kg/m2 (P = 4 × 10−6). Discussion: Low plasma levels of CRP at baseline were associated with high risk of AD in individuals from the general population. These observational findings were supported by genetic studies.

Published
2021
Full Text
View/download PDF

226. Genetic and Functional Characterization of ANGPTL7 as a Therapeutic Target for Glaucoma

Author

Scott Waldron, Alexander H. Li, Joan O'Brien, Katia Karalis, Stefanie Lefebvre, Gaurang Patel, Silvio Alessandro Di Gioia, Kristi Krebs, Hua Yang, Dadong Li, Ariane Ayer, Wen Fury, Ying Hu, Eric Jorgenson, James McIninch, Olle Melander, Giusy Della Gatta, Trikaladarshi Persaud, Ben Michael Brumpton, Claudia Schurmann, Stefan Stender, Eli A. Stahl, Michael N. Cantor, Venkata Gudiseva, Aris Baras, Marcus B. Jones, Dylan Sun, Jonathan Weyne, Manuel A. R. Ferreira, Tavé van Zyl, Lauren Gurski, Rebecca Salowe, Esteban Chen, Sarah Hyde, Gonçalo R. Abecasis, Kavita Praveen, Anne Tybjærg-Hansen, Giovanni Coppola, Matthew Still, Venkata Chavali, Tanya M. Teslovich, Lili Milani, Aris N. Economides, Sabrina Walley, Sarthak Zaveri, Kristian Hveem, Jeremey Rabinowitz, Carmelo Romano, Lawrence Miloscio, Bjørn Olav Åsvold, Brijeshkumar Patel, Cristen J. Willer, Anne-Sofie Seidelin, and George D. Yancopoulos

Subjects
genetic structures, business.industry, medicine, Glaucoma, sense organs, Computational biology, medicine.disease, business, eye diseases
Abstract

Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), a risk factor for glaucoma, but most treatments do not directly target the pathological changes leading to increased IOP, which can manifest as medication resistance as disease progresses. To identify physiological modulators of IOP, we performed genome- and exome-wide association analysis in >129,000 individuals with IOP measurements and extended these findings to an analysis of glaucoma risk. We report the identification and functional characterization of rare coding variants (including loss-of-function variants) in ANGPTL7 associated with reduction in IOP and glaucoma protection. We validated the human genetics findings in mice by establishing that Angptl7 knockout mice have lower (~2 mmHg) basal IOP compared to wild-type, with a trend towards lower IOP also in heterozygotes. Conversely, increasing mAngptl7 levels via injection into mouse eyes increases the IOP. We also show that acute gene silencing via siRNA knockdown of Angptl7 in adult mice lowers the IOP (~2-4 mmHg), reproducing the observations in knockout mice. Collectively, our data suggest that ANGPTL7 is important for IOP homeostasis and is amenable to therapeutic modulation to help maintain a healthy IOP that can prevent onset or slow the progression of glaucoma.

Published
2021
Full Text
View/download PDF

229. Impact of LDL Cholesterol on Microvascular Versus Macrovascular Disease

Author

Frida Emanuelsson, Børge G. Nordestgaard, Marianne Benn, and Anne Tybjærg-Hansen

Subjects
medicine.medical_specialty, education.field_of_study, Statin, business.industry, medicine.drug_class, Population, 030204 cardiovascular system & hematology, medicine.disease, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Meta-analysis, Internal medicine, Mendelian randomization, medicine, lipids (amino acids, peptides, and proteins), 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, education, Kidney disease, Macrovascular disease, Retinopathy
Abstract

Background Low-density lipoprotein cholesterol (LDL-C) is causally associated with a high risk of coronary artery disease. Whether this also holds for a spectrum of peripheral vascular diseases is unknown. Objectives The purpose of this study was to determine whether high LDL-C causally relates to risk of retinopathy, neuropathy, chronic kidney disease (CKD), and peripheral arterial disease (PAD) in the general population. Methods One-sample Mendelian randomization (MR) of 116,419 Danish individuals, 2-sample MR on summary-level data from the Global Lipid Genetics Consortium (GLGC) (n = 94,595) and the UK Biobank (n = 408,455), and meta-analysis of randomized statin trials (n = 64,134) were performed. Results Observationally, high LDL-C did not associate with high risk of retinopathy or neuropathy. There were stepwise increases in risk of CKD and PAD with higher LDL-C (both p for trend Conclusions High LDL-C was not causally associated with risk of retinopathy and neuropathy; however, high LDL-C was observationally and genetically associated with high risks of PAD and CKD, suggesting that LDL-C is causally involved in the pathogenesis of these diseases.

Published
2019
Full Text
View/download PDF

230. Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort

Author

Katrine L. Rasmussen, Børge G. Nordestgaard, Ruth Frikke-Schmidt, and Anne Tybjærg-Hansen

Subjects
Male, Apolipoprotein E, Prevention and Epidemiology, Survival, Genotype, Denmark, Population, General Population Cohort, Physiology, 030204 cardiovascular system & hematology, Cardiovascular, White People, Cohort Studies, 03 medical and health sciences, Apolipoproteins E, 0302 clinical medicine, Clinical Research, Cause of Death, Neoplasms, Humans, Medicine, Mortality, education, Prospective cohort study, 030304 developmental biology, 0303 health sciences, education.field_of_study, business.industry, Hazard ratio, Middle Aged, Confidence interval, Cardiovascular Diseases, Relative risk, Dementia, Female, Cardiology and Cardiovascular Medicine, business, APOE
Abstract

Aims To determine whether plasma apoE levels and APOE genotype are associated with all-cause and cause-specific mortality. Methods and results Using a prospective cohort design with 105 949 white individuals from the general population, we tested the association between plasma apoE at study enrolment and death during follow-up, and whether this was independent of APOE genotype. We confirmed the well-known association between APOE genotypes and mortality. For all-cause, cardiovascular, and cancer mortality, high levels of apoE were associated with increased risk, while for dementia-associated mortality low levels were associated with increased risk. For the highest vs. the fifth septile of plasma apoE, hazard ratios (HRs) were 1.20 (95% confidence interval 1.12–1.28) for all-cause mortality, 1.28 (1.13–1.44) for cardiovascular mortality, and 1.18 (1.05–1.32) for cancer mortality. Conversely, for the lowest vs. the fifth septile the HR was 1.44 (1.01–2.05) for dementia-associated mortality. Results were similar in analyses restricted to APOE ɛ33 carriers. Examining genetically determined plasma apoE, a 1 mg/dL increase conferred risk ratios of 0.97 (0.92–1.03) for cardiovascular mortality and 1.01 (0.95–1.06) for cancer mortality, while a 1 mg/dL decrease conferred a risk ratio of 1.70 (1.36–2.12) for dementia-associated mortality. Conclusion High plasma levels of apoE were associated with increased all-cause, cardiovascular, and cancer mortality, however of a non-causal nature, while low levels were causally associated with increased dementia-associated mortality.

Published
2019
Full Text
View/download PDF

231. Identification and Replication of Six Loci Associated With Gallstone Disease

Author

Helene Gellert‐Kristensen, Sune Fallgaard Nielsen, Stefan Stender, Anne Tybjærg-Hansen, N. Dalila, and Børge G. Nordestgaard

Subjects
0301 basic medicine, medicine.medical_specialty, Complex disease, Gallstones, Disease, Danish, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Hepatology, business.industry, Plasma levels, medicine.disease, Biobank, language.human_language, 030104 developmental biology, Increased risk, Genetic Loci, Susceptibility locus, language, 030211 gastroenterology & hepatology, business, Genome-Wide Association Study
Abstract

Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts. We extracted genetic associations with gallstone disease from the Global Biobank Engine (GBE), an online browser of genome-wide associations in UK Biobank participants (14,940 cases and 322,268 controls). Significant associations (P 2.5 (prevalence 1%) had a 5-fold increased risk of gallstones compared to those with a score

Published
2019
Full Text
View/download PDF

233. The UK10K project identifies rare variants in health and disease

Author

Walter, Klaudia, Min, Josine L., Huang, Jie, Crooks, Lucy, Memari, Yasin, Perry, John R. B., Xu, ChangJiang, Futema, Marta, Lawson, Daniel, Iotchkova, Valentina, Schiffels, Stephan, Hendricks, Audrey E., Danecek, Petr, Li, Rui, Floyd, James, Wain, Louise V., Humphries, Steve E., Barrett, Jeffrey C., Bala, Senduran, Clapham, Peter, Coates, Guy, Cox, Tony, Daly, Allan, Du, Yuanping, Edkins, Sarah, Ellis, Peter, Flicek, Paul, Guo, Xiaosen, Guo, Xueqin, Huang, Liren, Jackson, David K., Joyce, Chris, Keane, Thomas, Kolb-Kokocinski, Anja, Langford, Cordelia, Li, Yingrui, Liang, Jieqin, Lin, Hong, Liu, Ryan, Maslen, John, McCarthy, Shane, (co-chair), Muddyman, Dawn, Quail, Michael A., Stalker, Jim, (co-chair), Sun, Jianping, Tian, Jing, Wang, Guangbiao, Wang, Jun, Wang, Yu, Wong, Kim, Zhang, Pingbo, Birney, Ewan, Boustred, Chris, Chen, Lu, Clement, Gail, Cocca, Massimiliano, Smith, George Davey, Day, Ian N. M., Day-Williams, Aaron, Down, Thomas, Dunham, Ian, Evans, David M., Gaunt, Tom R., Geihs, Matthias, Hart, Deborah, Howie, Bryan, Hubbard, Tim, Hysi, Pirro, Jamshidi, Yalda, Karczewski, Konrad J., Kemp, John P., Lachance, Genevieve, Lek, Monkol, Lopes, Margarida, MacArthur, Daniel G., Marchini, Jonathan, Mangino, Massimo, Mathieson, Iain, Metrustry, Sarah, Moayyeri, Alireza, Northstone, Kate, Panoutsopoulou, Kalliope, Paternoster, Lavinia, Quaye, Lydia, Richards, Brent J., (co-chair), Ring, Susan, Ritchie, Graham R. S., Shihab, Hashem A., Shin, So-Youn, Small, Kerrin S., Artigas, María Soler, Soranzo, Nicole, (co-chair), Southam, Lorraine, Spector, Timothy D., St Pourcain, Beate, Surdulescu, Gabriela, Tachmazidou, Ioanna, Timpson, Nicholas J., (co-chair), Tobin, Martin D., Valdes, Ana M., Visscher, Peter M., Ward, Kirsten, Wilson, Scott G., Yang, Jian, Zhang, Feng, Zheng, Hou-Feng, Anney, Richard, Ayub, Muhammad, Blackwood, Douglas, Bolton, Patrick F., Breen, Gerome, Collier, David A., Craddock, Nick, Curran, Sarah, Curtis, David, Gallagher, Louise, Geschwind, Daniel, Gurling, Hugh, Holmans, Peter, Lee, Irene, Lönnqvist, Jouko, McGuffin, Peter, McIntosh, Andrew M., McKechanie, Andrew G., McQuillin, Andrew, Morris, James, OʼDonovan, Michael C., Owen, Michael J., (co-chair), Palotie, Aarno, (co-chair), Parr, Jeremy R., Paunio, Tiina, Pietilainen, Olli, Rehnström, Karola, Sharp, Sally I., Skuse, David, St Clair, David, Suvisaari, Jaana, Walters, James T. R., Williams, Hywel J., Barroso, Inês, (co-chair), Bochukova, Elena, Bounds, Rebecca, Dominiczak, Anna, Farooqi, Sadaf I., (co-chair), Keogh, Julia, Marenne, Gaëlle, Morris, Andrew, OʼRahilly, Stephen, Porteous, David J., Smith, Blair H., Wheeler, Eleanor, Al Turki, Saeed, Anderson, Carl A., Antony, Dinu, Beales, Phil, Bentham, Jamie, Bhattacharya, Shoumo, Calissano, Mattia, Carss, Keren, Chatterjee, Krishna, Cirak, Sebahattin, Cosgrove, Catherine, Fitzpatrick, David R., (co-chair), Foley, Reghan A., Franklin, Christopher S., Grozeva, Detelina, Hurles, Matthew E., (co-chair), Mitchison, Hannah M., Muntoni, Francesco, Onoufriadis, Alexandros, Parker, Victoria, Payne, Felicity, Raymond, Lucy F., Roberts, Nicola, Savage, David B., Scambler, Peter, Schmidts, Miriam, Schoenmakers, Nadia, Semple, Robert K., Serra, Eva, Spasic-Boskovic, Olivera, Stevens, Elizabeth, van Kogelenberg, Margriet, Vijayarangakannan, Parthiban, Williamson, Kathleen A., Wilson, Crispian, Whyte, Tamieka, Ciampi, Antonio, Greenwood, Celia M. T., (co-chair), Oualkacha, Karim, Zeggini, Eleftheria, (co-chair), Bobrow, Martin, Griffin, Heather, Kaye, Jane, (co-chair), Kennedy, Karen, Kent, Alastair, Smee, Carol, Charlton, Ruth, Ekong, Rosemary, Khawaja, Farrah, Lopes, Luis R., Migone, Nicola, Payne, Stewart J., Plagnol, Vincent, (chair), Pollitt, Rebecca C., Povey, Sue, Ridout, Cheryl K., Robinson, Rachel L., Scott, Richard H., Shaw, Adam, Syrris, Petros, Taylor, Rohan, Vandersteen, Anthony M., Durbin, Richard, (chair), Amuzu, Antoinette, Casas, Juan Pablo, Chambers, John C., Dedoussis, George, Gambaro, Giovanni, Gasparini, Paolo, Isaacs, Aaron, Johnson, Jon, Kleber, Marcus E., Kooner, Jaspal S., Langenberg, Claudia, Luan, Jianʼan, Malerba, Giovanni, März, Winfried, Matchan, Angela, Morris, Richard, Nordestgaard, Børge G., Benn, Marianne, Scott, Robert A., Toniolo, Daniela, Traglia, Michela, Tybjaerg-Hansen, Anne, van Duijn, Cornelia M., van Leeuwen, Elisabeth M., Varbo, Anette, Whincup, Peter, Zaza, Gianluigi, and Zhang, Weihua

Published
2015
Full Text
View/download PDF

239. Triglyceride-rich remnant lipoproteins are more atherogenic than LDL per particle: is this important?

Author

Tybjærg-Hansen, Anne, Nordestgaard, Børge G, and Christoffersen, Mette

Subjects
LIPOPROTEINS, LOW density lipoproteins, ATHEROSCLEROTIC plaque, DYSLIPIDEMIA, BLOOD lipids, HDL cholesterol
Abstract

In multivariable Mendelian randomization analysis, TRL/remnant-C was strongly and independently associated with CHD in models adjusted for both apoB and LDL-C. Furthermore, the causal CHD risk per 1 mmol/L higher cholesterol was significantly greater for TRL/remnant-C vs. The CHD risk per standard deviation (SD) higher apoB was considerably higher for cluster 2 vs. cluster 1 SNPs, implying that TRL/remnant particles have a substantially greater per particle atherogenicity than LDL. [Extracted from the article]

Published
2023
Full Text
View/download PDF

241. Obesity increases heart failure incidence and mortality: observational and Mendelian randomisation studies totalling over 1 million individuals

Author

Marianne Benn, Sarah C W Marott, Anne Tybjærg-Hansen, and Børge G Nordestgaard

Subjects
Physiology, Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Aims Whether high body mass index (BMI) causally influences development and prognosis of heart failure has implications for clinical practice. We tested the hypotheses that high BMI causally influences heart failure incidence and mortality. Methods and results Using observational and Mendelian randomization causal, genetic analyses, we studied 106 121 individuals from the Copenhagen General Population Study, 18 407 from the Copenhagen City Heart Study, and 977 323 from publicly available databases. In observational analyses in the Copenhagen studies with 10 years of median follow-up, multivariable adjusted hazard ratios per 1 kg/m2 increment of BMI were 1.06 (95% confidence interval: 1.05–1.07; P < 0.001; n = 124 528; events = 6589) for heart failure incidence, 1.04 (1.03–1.06; P < 0.001; n = 124 528; events = 1237) for heart failure mortality, and 1.01 (1.00–1.01; P < 0.001; n = 124 528; events = 24 144) for all-cause mortality. In genetic analyses in the Copenhagen studies, the age and sex adjusted causal risk ratios per 1 kg/m2 increment of BMI were 1.19 (1.05–1.36; P = 0.008; n = 118 200; events = 6541) for heart failure incidence, 1.27 (0.82–1.98; P = 0.28; n = 118 200; events = 889) for heart failure mortality, and 1.11 (1.02–1.22; P = 0.022; n = 118 200; events = 16 814) for all-cause mortality. Finally, combining genetic data from the Copenhagen studies, the Genetic Investigation of ANthropometric Traits, the Heart Failure Molecular Epidemiology for Therapeutic Targets, and the UK Biobank, the unadjusted causal risk ratios per 1 kg/m2 increment of BMI were 1.39 (1.27–1.52; P < 0.001; n = 1 095 523; events = 53 850) for heart failure incidence, 1.18 (1.00–1.38; P = 0.05; n = 576 853; events = 2373) for heart failure mortality, and 1.02 (1.00–1.04; P = 0.03; n = 576 853; events = 44 734) for all-cause mortality. Conclusion High BMI causally increases the risk of both heart failure incidence and mortality.

Published
2021

242. Low and high pancreatic amylase is associated with pancreatic cancer and chronic pancreatitis

Author

Signe E J, Hansen, Anne, Langsted, Anette, Varbo, Christian M, Madsen, Anne, Tybjærg-Hansen, and Børge G, Nordestgaard

Subjects
Adult, Aged, 80 and over, Male, Denmark, Pancreatic alpha-Amylases, Middle Aged, Pancreatic Neoplasms, Pancreatitis, Pancreatitis, Chronic, Amylases, Humans, Female, Biomarkers, Aged, Retrospective Studies
Abstract

Incidences of pancreatic cancer and acute and chronic pancreatitis are rising globally, and often no curative treatment is available at the time of diagnosis. We tested the hypothesis that low and high plasma concentrations of pancreatic amylase are associated with increased risk of pancreatic cancer, acute pancreatitis, and chronic pancreatitis in the general population. We included 101,765 individuals (55% women) aged 20-100 years from the Copenhagen General Population Study with baseline measurements of plasma pancreatic amylase. After recruitment in 2004-2015 during a median 9 years of follow-up (range 0-15), we collected information about diagnoses of pancreatic cancer, acute pancreatitis, and chronic pancreatitis from the national Danish Patient Registry, the national Danish Cancer Registry, and the national Danish Causes of Death Registry. The median age was 58 years (interquartile range: 48-67) and the median plasma pancreatic amylase 32 U/L (26-40). During follow-up, 442 individuals were diagnosed with pancreatic cancer, 282 with chronic pancreatitis, and 401 with acute pancreatitis. Compared to individuals with pancreatic amylase levels in the 41st-60th percentiles, those with extreme low (1st-2.5th percentiles) and extreme high (97.5th-100th percentiles) pancreatic amylase had hazard ratios of 2.4 (95% confidence interval; 1.6-3.6) and 2.2 (1.4-3.7) for pancreatic cancer, of 1.8 (1.1-3.3) and 3.2 (1.8-5.6) for chronic pancreatitis, and of 1.1 (0.6-1.8) and 1.5 (0.8-2.7) for acute pancreatitis, respectively. In apparently healthy individuals from the general population, extreme low and extreme high plasma pancreatic amylase were associated with 2-threefold higher risk of both pancreatic cancer and chronic pancreatitis.

Published
2021

243. Plasma Concentrations of Magnesium and Risk of Dementia:A General Population Study of 102 648 Individuals

Author

Janne Schurmann Tolstrup, Ruth Frikke-Schmidt, Børge G. Nordestgaard, Anne Tybjærg-Hansen, and Jesper Qvist Thomassen

Subjects
non-Alzheimer dementia, medicine.medical_specialty, Clinical Biochemistry, chemistry.chemical_element, Blood Pressure, 030204 cardiovascular system & hematology, magnesium, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Dementia, Humans, Magnesium, mediation analysis, Magnesium ion, Stroke, Proportional Hazards Models, Alzheimer dementia, business.industry, Biochemistry (medical), Hazard ratio, medicine.disease, Blood pressure, Endocrinology, chemistry, Population study, business, 030217 neurology & neurosurgery
Abstract

Background Low and high concentrations of plasma magnesium are associated with increased risk of future all-cause dementia; however, the underlying reasons remain elusive. The magnesium ion is an important electrolyte serving as a cofactor in many enzymatic processes in the human organism. Magnesium affects both neuronal and vascular functions. We investigated the associations of plasma concentrations of magnesium associate with common subtypes of dementia as Alzheimer dementia and non-Alzheimer dementia, and potential pathways by which magnesium may affect risk of dementia. Methods Plasma concentrations of magnesium were measured in 102 648 individuals from the Copenhagen General Population Study. Cox regression and natural effects mediation analyses evaluated associations with either Alzheimer dementia or non-Alzheimer dementia. Results Multifactorially adjusted hazard ratios for non-Alzheimer dementia were 1.50(95% confidence interval (CI):1.21–1.87) for the lowest and 1.34(1.07–1.69) for the highest vs the fourth quintile (reference) of plasma magnesium concentrations. Diabetes, cumulated smoking, stroke, and systolic blood pressure mediated 10.4%(3.1–22.8%), 6.8%(1.2–14.0%), 1.3%(0.1–3.6%), and 1.0%(0.2–2.6%), respectively, in the lowest quintile, whereas stroke mediated 3.2%(0.4–11.9%) in the highest quintile. No associations were observed for Alzheimer dementia. Conclusions Low and high plasma magnesium concentrations were associated with high risk of vascular-related non-Alzheimer dementia, with the lowest risk observed at a concentration of 2.07 mg/dL (0.85 mmol/L). No association was observed for Alzheimer dementia. Mediation analysis suggested that diabetes may be in the causal pathway between low plasma magnesium concentrations and high risk of non-Alzheimer dementia, while cumulated smoking, stroke, and systolic blood pressure played minor mediating roles.

Published
2021
Full Text
View/download PDF

245. Obesity increases heart failure incidence and mortality: observational and Mendelian randomization studies totalling over 1 million individuals.

Author

Benn, Marianne, Marott, Sarah C W, Tybjærg-Hansen, Anne, and Nordestgaard, Børge G

Subjects
HEART failure, BODY mass index, OBESITY, MOLECULAR epidemiology, OBESITY paradox, MORTALITY
Abstract

Aims Whether high body mass index (BMI) causally influences development and prognosis of heart failure has implications for clinical practice. We tested the hypotheses that high BMI causally influences heart failure incidence and mortality. Methods and results Using observational and Mendelian randomization causal, genetic analyses, we studied 106 121 individuals from the Copenhagen General Population Study, 18 407 from the Copenhagen City Heart Study, and 977 323 from publicly available databases. In observational analyses in the Copenhagen studies with 10 years of median follow-up, multivariable adjusted hazard ratios per 1 kg/m2 increment of BMI were 1.06 (95% confidence interval: 1.05–1.07; P < 0.001; n = 124 528; events = 6589) for heart failure incidence, 1.04 (1.03–1.06; P < 0.001; n = 124 528; events = 1237) for heart failure mortality, and 1.01 (1.00–1.01; P < 0.001; n = 124 528; events = 24 144) for all-cause mortality. In genetic analyses in the Copenhagen studies, the age and sex adjusted causal risk ratios per 1 kg/m2 increment of BMI were 1.19 (1.05–1.36; P = 0.008; n = 118 200; events = 6541) for heart failure incidence, 1.27 (0.82–1.98; P = 0.28; n = 118 200; events = 889) for heart failure mortality, and 1.11 (1.02–1.22; P = 0.022; n = 118 200; events = 16 814) for all-cause mortality. Finally, combining genetic data from the Copenhagen studies, the Genetic Investigation of ANthropometric Traits, the Heart Failure Molecular Epidemiology for Therapeutic Targets, and the UK Biobank, the unadjusted causal risk ratios per 1 kg/m2 increment of BMI were 1.39 (1.27–1.52; P < 0.001; n = 1 095 523; events = 53 850) for heart failure incidence, 1.18 (1.00–1.38; P = 0.05; n = 576 853; events = 2373) for heart failure mortality, and 1.02 (1.00–1.04; P = 0.03; n = 576 853; events = 44 734) for all-cause mortality. Conclusion High BMI causally increases the risk of both heart failure incidence and mortality. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

247. Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype

Author

Ruth Frikke-Schmidt, Børge G. Nordestgaard, Birgit Agerholm-Larsen, Peter Schnohr, and Anne Tybjærg-Hansen

Subjects
genes, atherosclerosis, interactions, Biochemistry, QD415-436
Abstract

Variation in apolipoprotein (apo)E genotypes predicts variation in plasma cholesterol and apoB; however, the context-dependent associations between high density lipoprotein (HDL) cholesterol, apoA-I, triglycerides, and lipoprotein[a] (Lp[a]) and this polymorphism remain unsettled. We genotyped 5,025 women and 4,035 men sampled to represent a white general population in the age range 20 to 80+ years (mean ages 58 and 57 years for women and men, respectively). The relative frequencies of the ε22, ε32, ε42, ε33, ε43, and ε44 genotypes were 0.005, 0.127, 0.027, 0.564, 0.251, and 0.027, respectively. Variations in apoE genotype (in the order listed above) predicted stepwise increases in cholesterol and apoB in both genders (all ANOVAs: P < 0.001), and stepwise decreases in HDL cholesterol and apoA-I in women (both ANOVAs: P < 0.001), but not in men. In both genders ε33 individuals had the lowest levels of nonfasting triglycerides, whereas the highest levels were found in individuals with ε22 and ε44 genotypes (both ANOVAs: P < 0.001). Finally, a stepwise increase in Lp[a] was seen in women (ANOVA: P < 0.001), but not in men. In women, the association between variation in nonfasting triglycerides and Lp[a], and variation in apoE genotypes was mainly seen in those with the highest alcohol consumption, similar to the consumption of most men. Variations in apoE genotype predicted 5% and 11% in women, and 2% and 6% in men, of the total variation in plasma cholesterol and apoB, respectively. Variation in levels of plasma lipoproteins is associated with variation in apoE genotypes in the population at large, with the most pronounced association in women, except for nonfasting triglycerides, for which the association is most pronounced in men. Whereas the associations between variation in plasma cholesterol and apoB and the variation in apoE genotypes seem invariant, the associations with variation in plasma HDL cholesterol, apoA-I, nonfasting triglycerides, and Lp[a] seem context dependent.—Frikke-Schmidt, R., B. G. Nordestgaard, B. Agerholm-Larsen, P. Schnohr, and A. Tybjærg-Hansen. Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype. J. Lipid Res. 2000. 41: 1812–1822.

Published
2000
Full Text
View/download PDF

248. Abstract 10469: Cardiometabolic Risk Factors as Causal Mediators of the Relationship Between High Body Mass Index and Chronic Kidney Disease: A Two-Step Mendelian Randomization Study and Mediation Analyses

Author

Emanuelsson, Frida, primary, Wade, Kaitlin, additional, Varbo, Anette, additional, Tybjaerg-hansen, Anne, additional, Davey Smith, George, additional, Nordestgaard, Borge G, additional, Benn, Marianne, additional, and Timpson, Nicholas, additional

Published
2021
Full Text
View/download PDF

250. Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Author

Vallejo-Vaz, Antonio J., primary, Stevens, Christophe A.T., additional, Lyons, Alexander R.M., additional, Dharmayat, Kanika I., additional, Freiberger, Tomas, additional, Hovingh, G. Kees, additional, Mata, Pedro, additional, Raal, Frederick J., additional, Santos, Raul D., additional, Soran, Handrean, additional, Watts, Gerald F., additional, Abifadel, Marianne, additional, Aguilar-Salinas, Carlos A., additional, Alhabib, Khalid F., additional, Alkhnifsawi, Mutaz, additional, Almahmeed, Wael, additional, Alnouri, Fahad, additional, Alonso, Rodrigo, additional, Al-Rasadi, Khalid, additional, Al-Sarraf, Ahmad, additional, Al-Sayed, Nasreen, additional, Araujo, Francisco, additional, Ashavaid, Tester F., additional, Banach, Maciej, additional, Béliard, Sophie, additional, Benn, Marianne, additional, Binder, Christoph J., additional, Bogsrud, Martin P., additional, Bourbon, Mafalda, additional, Chlebus, Krzysztof, additional, Corral, Pablo, additional, Davletov, Kairat, additional, Descamps, Olivier S., additional, Durst, Ronen, additional, Ezhov, Marat, additional, Gaita, Dan, additional, Genest, Jacques, additional, Groselj, Urh, additional, Harada-Shiba, Mariko, additional, Holven, Kirsten B., additional, Kayikcioglu, Meral, additional, Khovidhunkit, Weerapan, additional, Lalic, Katarina, additional, Latkovskis, Gustavs, additional, Laufs, Ulrich, additional, Liberopoulos, Evangelos, additional, Lima-Martinez, Marcos M., additional, Lin, Jie, additional, Maher, Vincent, additional, Marais, A. David, additional, März, Winfried, additional, Mirrakhimov, Erkin, additional, Miserez, André R., additional, Mitchenko, Olena, additional, Nawawi, Hapizah, additional, Nordestgaard, Børge G., additional, Panayiotou, Andrie G., additional, Paragh, György, additional, Petrulioniene, Zaneta, additional, Pojskic, Belma, additional, Postadzhiyan, Arman, additional, Raslova, Katarina, additional, Reda, Ashraf, additional, Reiner, Željko, additional, Sadiq, Fouzia, additional, Sadoh, Wilson Ehidiamen, additional, Schunkert, Heribert, additional, Shek, Aleksandr B., additional, Stoll, Mario, additional, Stroes, Erik, additional, Su, Ta-Chen, additional, Subramaniam, Tavintharan, additional, Susekov, Andrey V., additional, Tilney, Myra, additional, Tomlinson, Brian, additional, Truong, Thanh Huong, additional, Tselepis, Alexandros D., additional, Tybjærg-Hansen, Anne, additional, Vázquez Cárdenas, Alejandra, additional, Viigimaa, Margus, additional, Wang, Luya, additional, Yamashita, Shizuya, additional, Kastelein, John J.P., additional, Bruckert, Eric, additional, Vohnout, Branislav, additional, Schreier, Laura, additional, Pang, Jing, additional, Ebenbichler, Christoph, additional, Dieplinger, Hans, additional, Innerhofer, Reinhold, additional, Winhofer-Stöckl, Yvonne, additional, Greber-Platzer, Susanne, additional, Krychtiuk, Konstantin, additional, Speidl, Walter, additional, Toplak, Hermann, additional, Widhalm, Kurt, additional, Stulnig, Thomas, additional, Huber, Kurt, additional, Höllerl, Florian, additional, Rega-Kaun, Gersina, additional, Kleemann, Lucas, additional, Mäser, Martin, additional, Scholl-Bürgi, Sabine, additional, Säly, Christoph, additional, Mayer, Florian J., additional, Sablon, Gaelle, additional, Tarantino, Eric, additional, Nzeyimana, Charlotte, additional, Pojskic, Lamija, additional, Sisic, Ibrahim, additional, Nalbantic, Azra D., additional, Jannes, Cinthia E., additional, Pereira, Alexandre C., additional, Krieger, Jose E., additional, Petrov, Ivo, additional, Goudev, Assen, additional, Nikolov, Fedya, additional, Tisheva, Snejana, additional, Yotov, Yoto, additional, Tzvetkov, Ivajlo, additional, Baass, Alexis, additional, Bergeron, Jean, additional, Bernard, Sophie, additional, Brisson, Diane, additional, Brunham, Liam R., additional, Cermakova, Lubomira, additional, Couture, Patrick, additional, Francis, Gordon A., additional, Gaudet, Daniel, additional, Hegele, Robert A., additional, Khoury, Etienne, additional, Mancini, G.B. John, additional, McCrindle, Brian W., additional, Paquette, Martine, additional, Ruel, Isabelle, additional, Cuevas, Ada, additional, Asenjo, Sylvia, additional, Wang, Xumin, additional, Meng, Kang, additional, Song, Xiantao, additional, Yong, Qiang, additional, Jiang, Tao, additional, Liu, Ziyou, additional, Duan, Yanyu, additional, Hong, Jing, additional, Ye, Pucong, additional, Chen, Yan, additional, Qi, Jianguang, additional, Liu, Zesen, additional, Li, Yuntao, additional, Zhang, Chaoyi, additional, Peng, Jie, additional, Yang, Ya, additional, Yu, Wei, additional, Wang, Qian, additional, Yuan, Hui, additional, Cheng, Shitong, additional, Jiang, Long, additional, Chong, Mei, additional, Jiao, Jian, additional, Wu, Yue, additional, Wen, Wenhui, additional, Xu, Liyuan, additional, Zhang, Ruiying, additional, Qu, Yichen, additional, He, Jianxun, additional, Fan, Xuesong, additional, Wang, Zhenjia, additional, Chow, Elaine, additional, Pećin, Ivan, additional, Perica, Dražen, additional, Symeonides, Phivos, additional, Vrablik, Michal, additional, Ceska, Richard, additional, Soska, Vladimir, additional, Tichy, Lukas, additional, Adamkova, Vera, additional, Franekova, Jana, additional, Cifkova, Renata, additional, Kraml, Pavel, additional, Vonaskova, Katerina, additional, Cepova, Jana, additional, Dusejovska, Magdalena, additional, Pavlickova, Lenka, additional, Blaha, Vladimir, additional, Rosolova, Hana, additional, Nussbaumerova, Barbora, additional, Cibulka, Roman, additional, Vaverkova, Helena, additional, Cibickova, Lubica, additional, Krejsova, Zdenka, additional, Rehouskova, Katerina, additional, Malina, Pavel, additional, Budikova, Milena, additional, Palanova, Vaclava, additional, Solcova, Lucie, additional, Lubasova, Alena, additional, Podzimkova, Helena, additional, Bujdak, Juraj, additional, Vesely, Jiri, additional, Jordanova, Marta, additional, Salek, Tomas, additional, Urbanek, Robin, additional, Zemek, Stanislav, additional, Lacko, Jan, additional, Halamkova, Hana, additional, Machacova, Sona, additional, Mala, Sarka, additional, Cubova, Eva, additional, Valoskova, Katerina, additional, Burda, Lukas, additional, Bendary, Ahmed, additional, Daoud, Ihab, additional, Emil, Sameh, additional, Elbahry, Atef, additional, Rafla, Samir, additional, Sanad, Osama, additional, Kazamel, Ghada, additional, Ashraf, Mohamed, additional, Sobhy, Mohamed, additional, El-Hadidy, Amro, additional, Shafy, Mohamed A., additional, Kamal, Saif, additional, Bendary, Mohamed, additional, Talviste, Grete, additional, Angoulvant, Denis, additional, Boccara, Franck, additional, Cariou, Bertrand, additional, Carreau, Valérie, additional, Carrie, Alain, additional, Charrieres, Sybil, additional, Cottin, Yves, additional, Di-Fillipo, Mathilde, additional, Ducluzeau, Pierre H., additional, Dulong, Sonia, additional, Durlach, Vincent, additional, Farnier, Michel, additional, Ferrari, Emile, additional, Ferrieres, Dorota, additional, Ferrieres, Jean, additional, Gallo, Antonio, additional, hankard, Regis, additional, Inamo, Jocelyne, additional, Lemale, Julie, additional, Moulin, Philippe, additional, Paillard, François, additional, Peretti, Noel, additional, Perrin, Agnès, additional, Pradignac, Alain, additional, Rabes, Jean P., additional, Rigalleau, Vincent, additional, Sultan, Ariane, additional, Schiele, François, additional, Tounian, Patrick, additional, Valero, René, additional, Verges, Bruno, additional, Yelnik, Cécile, additional, Ziegler, Olivier, additional, Haack, Ira A., additional, Schmidt, Nina, additional, Dressel, Alexander, additional, Klein, Isabel, additional, Christmann, Jutta, additional, Sonntag, Antonia, additional, Stumpp, Christine, additional, Boger, Diana, additional, Biedermann, Dana, additional, Usme, Monica M.N., additional, Beil, F. Ulrich, additional, Klose, Gerald, additional, König, Christel, additional, Gouni-Berthold, Ioanna, additional, Otte, Britta, additional, Böll, Gereon, additional, Kirschbaum, Anja, additional, Merke, Jürgen, additional, Scholl, Johannes, additional, Segiet, Thomas, additional, Gebauer, Marco, additional, Predica, Florentina, additional, Mayer, Manfred, additional, Leistikow, Frank, additional, Füllgraf-Horst, Sabine, additional, Müller, Cornelius, additional, Schüler, Melanie, additional, Wiener, Judith, additional, Hein, Konrad, additional, Baumgartner, Peter, additional, Kopf, Stefan, additional, Busch, Reinhold, additional, Schömig, Michael, additional, Matthias, Stephan, additional, Allendorf-Ostwald, Nicole, additional, Fink, Bruno, additional, Böhm, Dieter, additional, Jäkel, Alexander, additional, Koschker, Ann-Cathrin, additional, Schweizer, Rüdiger, additional, Vogt, Anja, additional, Parhofer, Klaus, additional, König, Wolfgang, additional, Reinhard, Wibke, additional, Bäßler, Andrea, additional, Stadelmann, Alexander, additional, Schrader, Volker, additional, Katzmann, Julius, additional, Tarr, Adrienne, additional, Steinhagen-Thiessen, Elisabeth, additional, Kassner, Ursula, additional, Paulsen, Gerret, additional, Homberger, Jürgen, additional, Zemmrich, Claudia, additional, Seeger, Wolfgang, additional, Biolik, Kathrin, additional, Deiss, Dorothee, additional, Richter, Corinna, additional, Pantchechnikova, Elina, additional, Dorn, Elena, additional, Schatz, Ulrike, additional, Julius, Ulrich, additional, Spens, Antje, additional, Wiesner, Tobias, additional, Scholl, Michael, additional, Rizos, Christos V., additional, Sakkas, Nikolaos, additional, Elisaf, Moses, additional, Skoumas, Ioannis, additional, Tziomalos, Konstantinos, additional, Rallidis, Loukianos, additional, Kotsis, Vasileios, additional, Doumas, Michalis, additional, Athyros, Vasileios, additional, Skalidis, Emmanouil, additional, Kolovou, Genovefa, additional, Garoufi, Anastasia, additional, Bilianou, Eleni, additional, Koutagiar, Iosif, additional, Agapakis, Dimitrios, additional, Kiouri, Estela, additional, Antza, Christina, additional, Katsiki, Niki, additional, Zacharis, Evangelos, additional, Attilakos, Achilleas, additional, Sfikas, George, additional, Koumaras, Charalambos, additional, Anagnostis, Panagiotis, additional, Anastasiou, Georgia, additional, Liamis, George, additional, Koutsogianni, Amalia-Despoina, additional, Karányi, Zsolt, additional, Harangi, Mariann, additional, Bajnok, László, additional, Audikovszky, Mária, additional, Márk, László, additional, Benczúr, Béla, additional, Reiber, István, additional, Nagy, Gergely, additional, Nagy, András, additional, Reddy, Lakshmi L., additional, Shah, Swarup A.V., additional, Ponde, Chandrashekhar K., additional, Dalal, Jamshed J., additional, Sawhney, Jitendra P.S., additional, Verma, Ishwar C., additional, Altaey, Mays, additional, Al-Jumaily, Khalid, additional, Rasul, Dilshad, additional, Abdalsahib, Ali F., additional, Jabbar, Amer A., additional, Al-ageedi, Mohanad, additional, Agar, Ruth, additional, Cohen, Hofit, additional, Ellis, Avishay, additional, Gavishv, Dov, additional, Harats, Dror, additional, Henkin, Yaacov, additional, Knobler, Hila, additional, Leavit, Leah, additional, Leitersdorf, Eran, additional, Rubinstein, Ardon, additional, Schurr, Daniel, additional, Shpitzen, Shoshi, additional, Szalat, Auryan, additional, Casula, Manuela, additional, Zampoleri, Veronica, additional, Gazzotti, Marta, additional, Olmastroni, Elena, additional, Sarzani, Riccardo, additional, Ferri, Claudio, additional, Repetti, Elena, additional, Sabbà, Carlo, additional, Bossi, Antonio Carlo, additional, Borghi, Claudio, additional, Muntoni, Sandro, additional, Cipollone, Francesco, additional, Purrello, Francesco, additional, Pujia, Arturo, additional, Passaro, Angelina, additional, Marcucci, Rossella, additional, Pecchioli, Valerio, additional, Pisciotta, Livia, additional, Mandraffino, Giuseppe, additional, Pellegatta, Fabio, additional, Mombelli, Giuliana, additional, Branchi, Adriana, additional, Fiorenza, Anna Maria, additional, Pederiva, Cristina, additional, Werba, Josè Pablo, additional, Parati, Gianfranco, additional, Carubbi, Francesca, additional, Iughetti, Lorenzo, additional, Iannuzzi, Arcangelo, additional, Iannuzzo, Gabriella, additional, Calabrò, Paolo, additional, Averna, Maurizio, additional, Biasucci, Giacomo, additional, Zambon, Sabina, additional, Roscini, Anna Rita, additional, Trenti, Chiara, additional, Arca, Marcello, additional, Federici, Massimo, additional, Del Ben, Maria, additional, Bartuli, Andrea, additional, Giaccari, Andrea, additional, Pipolo, Antonio, additional, Citroni, Nadia, additional, Guardamagna, Ornella, additional, Bonomo, Katia, additional, Benso, Andrea, additional, Biolo, Gianni, additional, Maroni, Lorenzo, additional, Lupi, Alessandro, additional, Bonanni, Luca, additional, Zenti, Maria Grazia, additional, Matsuki, Kota, additional, Hori, Mika, additional, Ogura, Masatsune, additional, Masuda, Daisaku, additional, Kobayashi, Takuya, additional, Nagahama, Kumiko, additional, Al-Jarallah, Mohammed, additional, Radovic, Mirjana, additional, Lunegova, Olga, additional, Bektasheva, Erkayim, additional, Khodzhiboboev, Elyor, additional, Erglis, Andrejs, additional, Gilis, Dainus, additional, Nesterovics, Georgijs, additional, Saripo, Vita, additional, Meiere, Ruta, additional, Upena-RozeMicena, Arta, additional, Terauda, Elizabete, additional, Jambart, Selim, additional, Khoury, Petra E., additional, Elbitar, Sandy, additional, Ayoub, Carine, additional, Ghaleb, Youmna, additional, Aliosaitiene, Urte, additional, Kutkiene, Sandra, additional, Kasim, Noor A.M., additional, Nor, Noor S.M., additional, Ramli, Anis S., additional, Razak, Suraya A., additional, Al-Khateeb, Alyaa, additional, Kadir, Siti H.S.A., additional, Muid, Suhaila A., additional, Rahman, Thuhairah A., additional, Kasim, Sazzli S., additional, Radzi, Ahmad B.M., additional, Ibrahim, Khairul S., additional, Razali, Salmi, additional, Ismail, Zaliha, additional, Ghani, Rohana A., additional, Hafidz, Muhammad I.A., additional, Chua, Ang L., additional, Rosli, Marshima M., additional, Annamalai, Muthukkaruppan, additional, Teh, Lay K., additional, Razali, Rafezah, additional, Chua, Yung A., additional, Rosman, Azhari, additional, Sanusi, Abdul R., additional, Murad, Nor A.A., additional, Jamal, A. Rahman A., additional, Nazli, Sukma A., additional, Razman, Aimi Z., additional, Rosman, Norhidayah, additional, Rahmat, Radzi, additional, Hamzan, Nur S., additional, Azzopardi, C., additional, Mehta, Roopa, additional, Martagon, Alexandro J., additional, Ramirez, Gabriela A.G., additional, Villa, Neftali E.A., additional, Vazquez, Arsenio V., additional, Elias-Lopez, Daniel, additional, Retana, Gustavo G., additional, Rodriguez, Betsabel, additional, Macías, Jose J.C., additional, Zazueta, Alejandro R., additional, Alvarado, Rocio M., additional, Portano, Julieta D.M., additional, Lopez, Humberto A., additional, Sauque-Reyna, Leobardo, additional, Herrera, Laura G.G., additional, Mendia, Luis E.S., additional, Aguilar, Humberto Garcia, additional, Cooremans, Elizabeth R., additional, Aparicio, Berenice P., additional, Zubieta, Victoria M., additional, Gonzalez, Perla A.C., additional, Ferreira-Hermosillo, Aldo, additional, Portilla, Nacu C., additional, Dominguez, Guadalupe J., additional, Garcia, Alinna Y.R., additional, Cazares, Hector E.A., additional, Gonzalez, Jesus R., additional, Valencia, Carla V.M., additional, Padilla, Francisco G., additional, Prado, Ramon M., additional, De los Rios Ibarra, Manuel O., additional, Villicaña, Ruy D.A., additional, Rivera, Karina J.A., additional, Carrera, Ricardo A., additional, Alvarez, Jose A., additional, Martinez, Jose C.A., additional, de los Reyes Barrera Bustillo, Manuel, additional, Vargas, Gonzalo C., additional, Chacon, Roberto C., additional, Andrade, Mario H.F., additional, Ortega, Ashanty F., additional, Alcala, Hector G., additional, de Leon, Laura E.G., additional, Guzman, Berenice G., additional, Garcia, Jose J.G., additional, Cuellar, Juan C.G., additional, Cruz, Jose R.G., additional, Garcia, Anell Hernandez, additional, Almada, Jesus R.H., additional, Herrera, Ursulo J., additional, Sobrevilla, Fabiola L., additional, Rodriguez, Eduardo M., additional, Sibaja, Cristina M., additional, Rodriguez, Alma B.M., additional, Oyervides, Jose C.M., additional, Vazquez, Daniel I.P., additional, Rodriguez, Eduardo A.R., additional, Osorio, Ma L.R., additional, Saucedo, Juan R., additional, Tamayo, Margarita T., additional, Talavera, Luis A.V., additional, Arroyo, Luis E.V., additional, Carrillo, Eloy A.Z., additional, Isara, Alphonsus, additional, Obaseki, Darlington E., additional, Al-Waili, Khalid, additional, Al-Zadjali, Fahad, additional, Al-Zakwani, Ibrahim, additional, Al-Kindi, Mohammed, additional, Al-Mukhaini, Suad, additional, Al-Barwani, Hamida, additional, Rana, Asim, additional, Shah, Lahore S.U., additional, Starostecka, Ewa, additional, Konopka, Agnieszka, additional, Lewek, Joanna, additional, Bartłomiejczyk, Marcin, additional, Gąsior, Mariusz, additional, Dyrbuś, Krzysztof, additional, Jóźwiak, Jacek, additional, Gruchała, Marcin, additional, Pajkowski, Marcin, additional, Romanowska-Kocejko, Marzena, additional, Żarczyńska-Buchowiecka, Marta, additional, Chmara, Magdalena, additional, Wasąg, Bartosz, additional, Parczewska, Aleksandra, additional, Gilis-Malinowska, Natasza, additional, Borowiec-Wolna, Justyna, additional, Stróżyk, Aneta, additional, Woś, Marlena, additional, Michalska-Grzonkowska, Aleksandra, additional, Medeiros, Ana M., additional, Alves, Ana C., additional, Silva, Francisco, additional, Lobarinhas, Goreti, additional, Palma, Isabel, additional, de Moura, Jose P., additional, Rico, Miguel T., additional, Rato, Quitéria, additional, Pais, Patrícia, additional, Correia, Susana, additional, Moldovan, Oana, additional, Virtuoso, Maria J., additional, Salgado, Jose M., additional, Colaço, Ines, additional, Dumitrescu, Andreea, additional, Lengher, Calin, additional, Mosteoru, Svetlana, additional, Meshkov, Alexey, additional, Ershova, Alexandra, additional, Rozkova, Tatiana, additional, Korneva, Victoria, additional, Yu, Kuznetsova T., additional, Zafiraki, Vitaliy, additional, Voevoda, Mikhail, additional, Gurevich, Victor, additional, Duplyakov, Dmitry, additional, Ragino, Yulia, additional, Safarova, Maya, additional, Shaposhnik, Igor, additional, Alkaf, Fahmi, additional, Khudari, Alia, additional, Rwaili, Nawal, additional, Al-Allaf, Faisal, additional, Alghamdi, Mohammad, additional, Batais, Mohammed A., additional, Almigbal, Turky H., additional, Kinsara, Abdulhalim, additional, AlQudaimi, Ashraf H.A., additional, Awan, Zuhier, additional, Elamin, Omer A., additional, Altaradi, Hani, additional, Rajkovic, Natasa, additional, Popovic, Ljiljana, additional, Singh, Sandra, additional, Stosic, Ljubica, additional, Rasulic, Iva, additional, Lalic, Nebojsa M., additional, Lam, Carolyn, additional, Le, Tan J., additional, Siang, Eric L.T., additional, Dissanayake, Sanjaya, additional, I-Shing, Justin T., additional, Shyong, Tai E., additional, Jin, Terrance C.S., additional, Balinth, Karin, additional, Buganova, Ingrid, additional, Fabryova, Lubomira, additional, Kadurova, Michaela, additional, Klabnik, Alexander, additional, Kozárová, Miriam, additional, Sirotiakova, Jana, additional, Battelino, Tadej, additional, Kovac, Jernej, additional, Mlinaric, Matej, additional, Sustar, Ursa, additional, Podkrajsek, Katarina T., additional, Fras, Zlatko, additional, Jug, Borut, additional, Cevc, Matija, additional, Pilcher, Gillian J., additional, Blom, D.J., additional, Wolmarans, K.H., additional, Brice, B.C., additional, Muñiz-Grijalvo, Ovidio, additional, Díaz-Díaz, Jose L., additional, de Isla, Leopoldo P., additional, Fuentes, Francisco, additional, Badimon, Lina, additional, Martin, François, additional, Lux, Angela, additional, Chang, Nien-Tzu, additional, Ganokroj, Poranee, additional, Akbulut, Mehmet, additional, Alici, Gökhan, additional, Bayram, Fahri, additional, Can, Levent H., additional, Celik, Ahmet, additional, Ceyhan, Ceyhun, additional, Coskun, Fatma Y., additional, Demir, Mesut, additional, Demircan, Sabri, additional, Dogan, Volkan, additional, Durakoglugil, Emre, additional, Dural, Ibrahim E., additional, Gedikli, Omer, additional, Hacioglu, Aysa, additional, Ildizli, Muge, additional, Kilic, Salih, additional, Kirilmaz, Bahadir, additional, Kutlu, Merih, additional, Oguz, Aytekin, additional, Ozdogan, Oner, additional, Onrat, Ersel, additional, Ozer, Savas, additional, Sabuncu, Tevfik, additional, Sahin, Tayfun, additional, Sivri, Fatih, additional, Sonmez, Alper, additional, Temizhan, Ahmet, additional, Topcu, Selim, additional, Tuncez, Abdullah, additional, Vural, Mirac, additional, Yenercag, Mustafa, additional, Yesilbursa, Dilek, additional, Yigit, Zerrin, additional, Yildirim, Aytul B., additional, Yildirir, Aylin, additional, Yilmaz, Mehmet B., additional, Atallah, Bassam, additional, Traina, Mahmoud, additional, Sabbour, Hani, additional, Hay, Dana A., additional, Luqman, Neama, additional, Elfatih, Abubaker, additional, Abdulrasheed, Arshad, additional, Kwok, See, additional, Oca, Nicolas D., additional, Reyes, Ximena, additional, Alieva, Rano B., additional, Kurbanov, Ravshanbek D., additional, Hoshimov, Shavkat U., additional, Nizamov, Ulugbek I., additional, Ziyaeva, Adolat V., additional, Abdullaeva, Guzal J., additional, Do, Doan L., additional, Nguyen, Mai N.T., additional, Kim, Ngoc T., additional, Le, Thanh T., additional, Le, Hong A., additional, Tokgozoglu, Lale, additional, Catapano, Alberico L., additional, and Ray, Kausik K., additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results