769 results on '"Tumminia A."'
Search Results
202. Introduction
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Tumminia, Diana G., primary
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- 2005
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203. Students and the Reality of Past-Life Therapy
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Tumminia, Diana G., primary
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- 2005
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204. Perfluorofluorenyl anions and their use as co-catalysts in the zirconocene-promoted polymerization of olefins
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Calderazzo, Fausto, Masi, Francesco, Pampaloni, Guido, Passarelli, Vincenzo, Santi, Roberto, Sommazzi, Anna, Spera, Silvia, and Tumminia, Francesca
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- 2005
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205. 'Adiponectin Paradox' and Cancer Risk: Is It Time for a Reevaluation of the Beneficial Effect of this Adipokine?
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Andrea Tumminia and Lucia Frittitta
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Oncology ,Risk ,medicine.medical_specialty ,cancer incidence ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Adipokine ,Type 2 diabetes ,Biochemistry ,Endocrinology ,Adipokines ,Internal medicine ,Neoplasms ,cancer mortality ,medicine ,Humans ,Cancer mortality ,Adiponectin ,business.industry ,Biochemistry (medical) ,adiponectin paradox ,medicine.disease ,Cancer incidence ,Diabetes Mellitus, Type 2 ,type 2 diabetes ,business ,Cancer risk - Published
- 2020
206. The prevalence of chronic kidney disease and screening of renal function in type 2 diabetic patients in Finnish primary healthcare
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Carla Loreto, Henry Sundqvist, Andrea Tumminia, Ilona Mikkola, Giuseppina T. Russo, Maria Hagnäs, Federica Vinciguerra, Jari Jokelainen, and Lucia Frittitta
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medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Population ,Renal function ,030209 endocrinology & metabolism ,Angiotensin-Converting Enzyme Inhibitors ,Type 2 diabetes ,urologic and male genital diseases ,Kidney ,03 medical and health sciences ,Angiotensin Receptor Antagonists ,0302 clinical medicine ,Chronic kidney disease ,Primary healthcare ,Renal insufficiency ,Screening ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Prevalence ,Albuminuria ,Humans ,030212 general & internal medicine ,Renal Insufficiency, Chronic ,education ,Finland ,Aged ,education.field_of_study ,Nutrition and Dietetics ,Primary Health Care ,business.industry ,medicine.disease ,female genital diseases and pregnancy complications ,Blood pressure ,Diabetes Mellitus, Type 2 ,Population study ,medicine.symptom ,Family Practice ,business ,Kidney disease ,Glomerular Filtration Rate - Abstract
Aims To estimate the prevalence of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) in Finnish primary healthcare, and to evaluate the screening for CKD and the proportions of patients receiving antihyperglycemic and cardiovascular preventive medication. Material and methods T2D patients treated at the Rovaniemi Health Center, Finland during the years 2015–2019. Data included patient characteristics, blood pressure, HbA1c, lipid levels, kidney function and albuminuria, and medications prescribed. CKD was defined as estimated glomerular filtration rate (eGFR) Results The study population comprised of 5112 T2D patients with a mean (SD) age of 66.7 (13.0) years. Of these, 60.2% were screened for CKD with both eGFR and albuminuria, and 30.1% of these patients had CKD. The prevalence of moderately increased and severely increased albuminuria was 19.6% and 3.2%, respectively. A total of 57.0% of the study population received angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB). Conclusions Screening for CKD with both recommended measures (eGFR and albuminuria) was insufficiently performed among this T2D population. Additionally, just over half of the study population had been prescribed ACE inhibitors or ARB. These results suggest an incongruity between the gold standard of diabetes care and real-world clinical practice.
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- 2020
207. Prevalence and clinical characteristics of children and adolescents with metabolically healthy obesity:role of insulin sensitivity
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Vinciguerra, F. (Federica), Tumminia, A. (Andrea), Baratta, R. (Roberto), Ferro, A. (Alfredo), Alaimo, S. (Salvatore), Hagnäs, M. (Maria), Graziano, M. (Marco), Vigneri, R. (Riccardo), and Frittitta, L. (Lucia)
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children ,insulin resistance ,nutritional and metabolic diseases ,metabolically healthy obesity ,adolescents ,metabolic syndrome - Abstract
Obesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of the MHO phenotype in a cohort of 246 overweight/obese Italian children and adolescents, and to evaluate their characteristics and the role of insulin resistance. Homeostasis model assessment–insulin resistance (HOMA-IR), insulin sensitivity index (ISI), insulinogenic index (IGI) and disposition index (DI) were all calculated from the Oral Glucose Tolerance Test (OGTT). MHO was defined by either: (1) HOMA-IR < 2.5 (MHO-IRes), or (2) absence of the criteria for metabolic syndrome (MHO-MetS). The MHO prevalence, according to MHO-MetS or MHO-IRes criteria, was 37.4% and 15.8%, respectively. ISI was the strongest predictor of the MHO phenotype, independently associated with both MHO-IRes and MHO-MetS. The MHO-MetS group was further subdivided into insulin sensitive or insulin resistant on the basis of HOMA-IR (either < or ≥ 2.5). Insulin sensitive MHO-MetS patients had a better metabolic profile compared to both insulin resistant MHO-MetS and MUO-MetS individuals. These data underscore the relevance of insulin sensitivity to identifying, among young individuals with overweight/obesity, the ones who have a more favorable metabolic phenotype.
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- 2020
208. D5.4 - Cost and life cycle analysis on advanced PEM electrolyser (HPEM2GAS) (R.E. 68/20)
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N. Briguglio, G. Tumminia, M. Ferraro, F. Sergi, F. Pantò, S. Siracusano, M. Giorgianni, M. Bottari V. Antonucci, A.S. Aricò (CNR) B. Green, and D. A. Greenhalgh (ITM) C. Oldani (SLV) L. Laila Grahl-Madsen (IRD) D. Greenhalgh (ITM)
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pem electrolysis - Abstract
High Performance PEM Electrolyser for Cost-effective Grid Balancing Applications
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- 2020
209. Heart and Soul
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Tumminia, Diana G., primary
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- 2004
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210. Genomics in the Era of Molecular Ophthalmology: Reflections on the National Ophthalmic Disease Genotyping Network (eyeGENE)
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Brooks, Brian P., MacDonald, Ian M., Tumminia, Santa J., Smaoui, Nizar, Blain, Delphine, Nezhuvingal, Ajaina A., and Sieving, Paul A.
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- 2008
211. Identifying Behavioral Phenotypes of Loneliness and Social Isolation with Passive Sensing: Statistical Analysis, Data Mining and Machine Learning of Smartphone and Fitbit Data
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Sheldon Cohen, Afsaneh Doryab, Jennifer Mankoff, Xinwen Liu, Kasey G. Creswell, Prerna Chikersal, Anind K. Dey, Daniella K. Villalba, Michael J. Tumminia, Janine M. Dutcher, and John David Creswell
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Data Analysis ,Male ,Psychological intervention ,computer.software_genre ,Logistic regression ,Machine Learning ,0302 clinical medicine ,Surveys and Questionnaires ,Data Mining ,030212 general & internal medicine ,Social isolation ,Microwaves ,digital phenotyping ,media_common ,4. Education ,Loneliness ,T58.5-58.64 ,Los Angeles ,Phenotype ,Social Isolation ,Feeling ,Female ,Smartphone ,Data mining ,medicine.symptom ,Public aspects of medicine ,RA1-1270 ,statistical data analysis ,Psychology ,Behavior Observation Techniques ,Evening ,Adolescent ,media_common.quotation_subject ,Health Informatics ,Information technology ,Machine learning ,Young Adult ,03 medical and health sciences ,loneliness ,medicine ,Humans ,Students ,mobile health ,Original Paper ,business.industry ,Behavioral pattern ,Mental health ,Artificial intelligence ,Sedentary Behavior ,Sleep ,business ,computer ,030217 neurology & neurosurgery - Abstract
Background: Feelings of loneliness are associated with poor physical and mental health. Detection of loneliness through passive sensing on personal devices can lead to the development of interventions aimed at decreasing rates of loneliness. Objective: The aim of this study was to explore the potential of using passive sensing to infer levels of loneliness and to identify the corresponding behavioral patterns. Methods: Data were collected from smartphones and Fitbits (Flex 2) of 160 college students over a semester. The participants completed the University of California, Los Angeles (UCLA) loneliness questionnaire at the beginning and end of the semester. For a classification purpose, the scores were categorized into high (questionnaire score>40) and low (≤40) levels of loneliness. Daily features were extracted from both devices to capture activity and mobility, communication and phone usage, and sleep behaviors. The features were then averaged to generate semester-level features. We used 3 analytic methods: (1) statistical analysis to provide an overview of loneliness in college students, (2) data mining using the Apriori algorithm to extract behavior patterns associated with loneliness, and (3) machine learning classification to infer the level of loneliness and the change in levels of loneliness using an ensemble of gradient boosting and logistic regression algorithms with feature selection in a leave-one-student-out cross-validation manner. Results: The average loneliness score from the presurveys and postsurveys was above 43 (presurvey SD 9.4 and postsurvey SD 10.4), and the majority of participants fell into the high loneliness category (scores above 40) with 63.8% (102/160) in the presurvey and 58.8% (94/160) in the postsurvey. Scores greater than 1 standard deviation above the mean were observed in 12.5% (20/160) of the participants in both pre- and postsurvey scores. The majority of scores, however, fell between 1 standard deviation below and above the mean (pre=66.9% [107/160] and post=73.1% [117/160]). Our machine learning pipeline achieved an accuracy of 80.2% in detecting the binary level of loneliness and an 88.4% accuracy in detecting change in the loneliness level. The mining of associations between classifier-selected behavioral features and loneliness indicated that compared with students with low loneliness, students with high levels of loneliness were spending less time outside of campus during evening hours on weekends and spending less time in places for social events in the evening on weekdays (support=17% and confidence=92%). The analysis also indicated that more activity and less sedentary behavior, especially in the evening, was associated with a decrease in levels of loneliness from the beginning of the semester to the end of it (support=31% and confidence=92%). Conclusions: Passive sensing has the potential for detecting loneliness in college students and identifying the associated behavioral patterns. These findings highlight intervention opportunities through mobile technology to reduce the impact of loneliness on individuals’ health and well-being.
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- 2019
212. Adipose Tissue, Obesity and Adiponectin: Role in Endocrine Cancer Risk
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Roberto Baratta, Laura Sciacca, Marco Graziano, Federica Vinciguerra, Andrea Tumminia, Miriam Parisi, and Lucia Frittitta
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0301 basic medicine ,obesity ,Adipose tissue ,Review ,medicine.disease_cause ,Bioinformatics ,lcsh:Chemistry ,0302 clinical medicine ,Hyperinsulinemia ,Insulin ,Neoplasm Metastasis ,lcsh:QH301-705.5 ,Spectroscopy ,General Medicine ,Computer Science Applications ,adipose tissue ,Cell Transformation, Neoplastic ,030220 oncology & carcinogenesis ,Receptors, Adiponectin ,hormones, hormone substitutes, and hormone antagonists ,Protein Binding ,Risk ,Adipokine ,Models, Biological ,Risk Assessment ,Catalysis ,Inorganic Chemistry ,Structure-Activity Relationship ,03 medical and health sciences ,Adiponectin ,Endocrine cancer ,Obesity ,Endocrine Gland Neoplasms ,Paracrine Communication ,medicine ,Animals ,Humans ,Endocrine system ,Physical and Theoretical Chemistry ,Molecular Biology ,adiponectin ,business.industry ,Organic Chemistry ,Cancer ,endocrine cancer ,medicine.disease ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,business ,Carcinogenesis ,Biomarkers ,Dyslipidemia - Abstract
Adipose tissue has been recognized as a complex organ with endocrine and metabolic roles. The excess of fat mass, as occurs during overweight and obesity states, alters the regulation of adipose tissue, contributing to the development of obesity-related disorders. In this regard, many epidemiological studies shown an association between obesity and numerous types of malignancies, comprising those linked to the endocrine system (e.g., breast, endometrial, ovarian, thyroid and prostate cancers). Multiple factors may contribute to this phenomenon, such as hyperinsulinemia, dyslipidemia, oxidative stress, inflammation, abnormal adipokines secretion and metabolism. Among adipokines, growing interest has been placed in recent years on adiponectin (APN) and on its role in carcinogenesis. APN is secreted by adipose tissue and exerts both anti-inflammatory and anti-proliferative actions. It has been demonstrated that APN is drastically decreased in obese individuals and that it can play a crucial role in tumor growth. Although literature data on the impact of APN on carcinogenesis are sometimes conflicting, the most accredited hypothesis is that it has a protective action, preventing cancer development and progression. The aim of the present review is to summarize the currently available evidence on the involvement of APN and its signaling in the etiology of cancer, focusing on endocrine malignancies.
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- 2019
213. Digital Technology for Diabetes.
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Tumminia, Andrea, Gullo, Damiano, and Frasca, Francesco
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The letter discusses a patient with type 1 diabetes whose glucose control and quality of life improved significantly after transitioning through different insulin therapy systems. While acknowledging disparities in technology access, the authors urge for discussions on patient screening and education regarding the use of diabetes technology, questioning the need for structured educational programs to optimize treatment efficacy and safety.
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- 2024
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214. Maximum Likelihood Identification of Cavitation Instabilities in Axial Inducers
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Giovanni Pace, Lucio Torre, Dario Valentini, Ruzbeh Hadavandi, Matteo Tumminia, Luca d'Agostino, and Angelo Pasini
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History ,Maximum likelihood ,Education ,Physics::Fluid Dynamics ,Rocket Propulsion ,Liquid Propellant Rocket Engines ,Turbopumps ,Inducer ,Inducers ,Rotating Cavitation ,Physics ,Cavitation ,Surge Cavitation ,Two-Phase Flows ,Mechanical Engineering ,Cavitation Auto-oscillations ,Cavitation-Induced Flow Instabilities ,Rocketry ,Aerospace Propulsion, Rocket Propulsion, Rocketry, Liquid Propellant Rocket Engines, Propellant Feed Turbopumps, Turbomachinery, Turbopumps, Inducers, Two-Phase Flows, Cavitation, Cavitation-Induced Flow Instabilities, Cavitation Auto-oscillations, Surge Cavitation, Rotating Cavitation ,Propellant Feed Turbopumps ,Computer Science Applications ,Turbomachinery ,Identification (biology) ,Aerospace Propulsion ,Biological system - Abstract
The article illustrates the results of an exploratory study on the effectiveness of maximum likelihood Bayesian estimation in the identification of cavitation instabilities in axial inducers using the blade-to-blade pressure measured by a single transducer flush-mounted on the impeller casing. The typical azimuthal distribution of the pressure in the blade channels is parameterized and modulated in space and time for theoretically reproducing the expected pressure generated by known forms of cavitation instabilities (cavitation surge auto-oscillations, n-lobed synchronous/asynchronous rotating cavitation, and higher-order surge/rotating cavitation modes). The power spectra of the theoretical pressure so obtained in the rotating frame are transformed in the stationary frame, corrected for frequency broadening effects, and parametrically fitted by maximum likelihood estimation to the measurements of the pressure on the inducer casing just downstream of the blade leading edges. In addition to its fundamental frequency, each form of instability generates a characteristic spectral distribution of sidebands. The identification uses this information for successfully discriminating flow oscillation modes occurring simultaneously with intensities differing by up to one order of magnitude. The method returns the estimates of the model parameters and their standard errors, allowing one to assess the accuracy and statistical significance of the identification. The results first demonstrate that elementary maximum likelihood Bayesian identification is indeed capable to effectively detect and characterize the occurrence of flow instabilities in cavitating inducers at a fraction of the experimental and postprocessing costs and complexities of traditional cross-correlation methods.
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- 2021
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215. Influence of the Mediterranean and Ketogenic Diets on cognitive status and decline:a narrative review
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Vinciguerra, F. (Federica), Graziano, M. (Marco), Hagnäs, M. (Maria), Frittitta, L. (Lucia), Tumminia, A. (Andrea), Vinciguerra, F. (Federica), Graziano, M. (Marco), Hagnäs, M. (Maria), Frittitta, L. (Lucia), and Tumminia, A. (Andrea)
- Abstract
Alzheimer’s disease (AD) is the most common form of senile dementia, accounting for up to 70% of dementia cases. AD is a slowly progressive disease, which causes global mental deterioration by affecting various cognitive areas. A growing body of evidence has demonstrated that lifestyle habits and nutritional patterns could delay the natural course of the neurodegeneration process. There is no single dietary pattern unequivocally proven to prevent AD. Nevertheless, epidemiological data suggest that by adopting several dietary habits, especially if accompanied with a healthy lifestyle, the negative consequences of AD could potentially be delayed. Alongside with others, two specific eating patterns have been well investigated concerning their potential beneficial effect on cognitive status: the Mediterranean diet (MedDi) and the Ketogenic Diet (KD). Despite the different underlying mechanisms, both of them have demonstrated a fairly profitable role in reducing or delaying cognitive impairment. The aim of the present narrative review is to overview the existing research on the efficacy of MedDi and KD against AD-related cognitive decline, focusing on the proposed protective mechanisms of action. Although the current knowledge on this complex topic does not allow us, at this point, to make exhaustive conclusions, this information could be of help in order to better characterize the possible role of MedDi and KD as nonpharmacological therapies in the treatment of AD and, more generically, of neurodegenerative disorders.
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- 2020
216. Tempol-H inhibits opacification of lenses in organ culture
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Zigler, Samuel J., Jr., Qin, Chuan, Kamiya, Toshikazu, Krishna, Murali C, Cheng, Qiufang, Tumminia, Santa, and Russell, Paul
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- 2003
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217. Optimal Design of Grid Integration of a Net Zero Energy Building trough Electrochemical Energy Storage and Fuel Cell Utilization
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Aloisio Davide, Ferraro Marco, Sergi Francesco, Brunaccini Giovanni, Randazzo Nicola, Tumminia Giovanni, Longo Sonia, Guarino Francesco, Cellura Maurizio, Antonucci Vincenzo, and Aloisio Davide, Ferraro Marco, Sergi Francesco, Brunaccini Giovanni, Randazzo Nicola, Tumminia Giovanni, Longo Sonia, Guarino Francesco, Cellura Maurizio, Antonucci Vincenzo
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Optimal Design, Grid Integration, Net Zero Energy Building, Electrochemical Energy Storage, Fuel Cell ,Settore ING-IND/11 - Fisica Tecnica Ambientale - Abstract
The integration of electrochemical energy storage, renewable energy production, and fuel cell systems can play a key role in the development of more efficient eco-friendly systems, spanning all sectors of energy management, from stationary to mobile. In particular, residential sector consumed 19% of worldwide energy production in 2015, resulting the third energivorous sector after transport and industry. Distributed energy systems, which efficiently use local resources, can reduce problems in regions with lack of a stable network and more in general help the growth of a sustainable development. In this case, the impact of PV-Lithium Batteries-SOFC integration in a NZEB (Net Zero Energy Builiding) is investigated by using software simulation, developed in Matlab/Simulink environment, to find optimal compromise between environment benefits, electricity grid independence, and costs. The NZEB was realized at CNR-ITAE laboratories by using eco-friendly technologies such as low environmental impact renewable FRP (Fiber Reinforced Pultruded) materials for its manufacturing, high efficiency PV panels, custom innovative multi-source inverter, advanced LiFeMgPO4 batteries, Solid Oxide Fuel Cell, optimized HVAC (Heating, Ventilation and Air Conditioning). Software simulation helps to evaluate and forecast the impact of all of the systems described upon, aiming to obtain an efficient energy management. At first, a monitoring campaign has been launched to evaluate loads consumption, PV production during the year and performances of single elements. After this, all data collected have been used to create models of all the systems present inside the building. The model developed permits to evaluate improvement parameters such as CO2 reduction, Load Cover Factor, Supply Cover Factor, estimate effective energy consumption and costs, and choose the right algorithm for energy management.
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- 2018
218. Climate change and the building sector: Modelling and energy implications to an office building in southern Europe
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Maurizio Cellura, Sonia Longo, Francesco Guarino, Giovanni Tumminia, Cellura, Maurizio, Guarino, Francesco, Longo, Sonia, and Tumminia, Giovanni
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Consumption (economics) ,Settore ING-IND/11 - Fisica Tecnica Ambientale ,Meteorology ,IPCC ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Geography, Planning and Development ,0211 other engineering and technologies ,Climate change ,Context (language use) ,02 engineering and technology ,Modelling climate change ,Management, Monitoring, Policy and Law ,Building simulation ,Order (exchange) ,Effects of global warming ,Greenhouse gas ,Range (aeronautics) ,Weather data file ,021105 building & construction ,0202 electrical engineering, electronic engineering, information engineering ,Environmental science ,Downscaling - Abstract
The building sector is one of the most relevant sectors in terms of generation of wealth and occupation, but it is also one of the main contributor to energy use and greenhouse gas emissions (e.g. at the European level it is currently responsible for 36% of CO2 emissions). For these reason this sector must play a key role in achieving a low-carbon economy consistent with the objective of holding the increase of the average temperature of the globe below 2 °C if compared to pre-industrial levels. In this context, the paper analyses the potential impact of climate change on the energy uses for heating and cooling in southern Europe, based on the assumptions of the latest Intergovernmental Panel on Climate Change (IPCC) future climate projections (assessment report 5). Different General Circulation Models (GCMs) were analysed using different metrics for selecting the most suitable one to be applied to building simulation. GCM data were used as input to a downscaling method known as “morphing”, to generate hourly weather files for 3 future time projections (2035, 2065 and 2090). Finally, in order to assess the building energy use for heating and cooling for the next century, energy simulations for a case study were performed. The results show, in all scenarios, consistent and large increases in future air temperature. The impacts of these driving forces on heating and cooling energy use are very relevant: the results show an overall increase in total energy consumption with a relative decrease in heating demand and increase in cooling demand: the yearly heating and cooling energy requirement in 2090 is expected to increase in a range of +50.8–119.7% if measures are not foreseen to counter and limit the effects of climate change.
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- 2018
219. The Mythic Dimensions of New Religious Movements: Function, Reality Construction, and Process
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Tumminia, Diana G., Kirkpatrick, R. George, and Lewis, James R., book editor
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- 2008
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220. PEG Precipitation to Detect Macro‐TSH in Clinical Practice: A Systematic Review.
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Piticchio, Tommaso, Chiardi, Isabella, Tumminia, Andrea, Frasca, Francesco, Rotondi, Mario, and Trimboli, Pierpaolo
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GEL permeation chromatography , *POLYETHYLENE glycol , *CLINICAL medicine , *NEWBORN infants , *SCIENTIFIC observation - Abstract
ABSTRACT Methods Results Conclusions Macro‐thyroid‐stimulating hormone (macro‐TSH) is a complex formed by monomeric TSH with anti‐TSH antibodies, causing falsely elevated TSH levels and potential misdiagnosis of hypothyroidism. Identification of macro‐TSH is essential for proper treatment and patient follow‐up. Its diagnostic gold standard is gel filtration chromatography (GFC), which is very expensive, time‐consuming, and rarely available. Polyethylene glycol (PEG) precipitation is more accessible and inexpensive. The aim of the study was to review evidence on PEG precipitation for the detection of macro‐TSH to standardize its application in clinical practice.According to PRISMA guidelines, we conducted up to August 2024 a comprehensive search of PubMed and Scopus databases, using terms related to macro‐TSH and PEG precipitation.We included 23 studies with 4476 subjects, encompassing 10 observational studies and 13 case series/reports. All studies showed a low risk of bias. They were conducted in tertiary centres and included newborns to elderly subjects. The most of evidence about the procedure has been achieved with PEG concentrations of 12.5%. The PEG‐precipitable TSH of the macro‐TSH cases was always higher than 75% ranging on average from 81% to 90%. No‐macro‐TSH cases (controls) showed a PEG‐precipitable TSH percentage ranging from 44.1% to 61.8%.PEG precipitation can be taken into account as a useful diagnostic tool for macro‐TSH. However, it is necessary to perform PEG precipitation in cases with a highly suspicious clinical picture and at the same time perform all available ancillary tests. PEG‐precipitable TSH > 75% can be considered a reliable diagnostic threshold for macro‐TSH cases. [ABSTRACT FROM AUTHOR]
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- 2024
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221. Effect of Climate Change on Building Performance: the Role of Ventilative Cooling
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Giovanni Tumminia, Francesco Guarino, Sonia Longo, Marina Mistretta, Maurizio Cellura, Cellura, M., Guarino, F., Longo, S., Mistretta, M., and Tumminia, G.
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Settore ING-IND/11 - Fisica Tecnica Ambientale ,Climatology ,Environmental science ,Climate change ,Building simulation, ventilative cooling, climate change - Abstract
Climate Change represents a priority, due to the large variety of implications and importance that it has reached throughout the last decades. In an effort to address this global and local challenge and in order to restrict temperature rise to 2 °C over the next century, it will need to address this topic from several angles, as confirmed by the last COP meetings in Paris and in Marrakech. In this context, the paper presents the modelling and assessment of ventilative cooling applicability in the future of the Mediteranean area under the effects of climate change. Results show that natural ventilation will continue to be of paramount importance in the Mediterranean climate but its highest effectiveness will be displaced from summer to spring and autumn.
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- 2017
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222. Why do non-artists draw the eyes too far up the head? How vertical eye-drawing errors relate to schematic knowledge, pseudoneglect, and context-based perceptual biases
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Michael J. Tumminia, Aaron Kozbelt, Matthew Cipriano, and Justin Ostrofsky
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Visual Arts and Performing Arts ,Head (linguistics) ,Knowledge level ,media_common.quotation_subject ,05 social sciences ,Schematic ,Attentional bias ,Context based ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Perception ,Developmental and Educational Psychology ,0501 psychology and cognitive sciences ,Psychology ,Social psychology ,030217 neurology & neurosurgery ,Applied Psychology ,Cognitive psychology ,media_common - Published
- 2016
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223. Sample Confirmation Testing: A Short Tandem Repeat-Based Quality Assurance and Quality Control Procedure for the eyeGENE Biorepository
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Remy C. Cooper, Kerry Goetz, Jemma Iano-Fletcher, Xinjing Wang, Annette Yim, Vida Ndifor, Rebecca S Parrish, Alexandra Garafalo, Santa J. Tumminia, and Melissa Reeves
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Quality Control ,0301 basic medicine ,medicine.medical_specialty ,Eye Diseases ,Sample (material) ,media_common.quotation_subject ,Medicine (miscellaneous) ,030105 genetics & heredity ,Eye ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Clinical genetic ,Humans ,Medicine ,Medical physics ,Quality (business) ,Biological Specimen Banks ,media_common ,business.industry ,Diagnostic test ,Original Articles ,Cell Biology ,General Medicine ,030104 developmental biology ,Biorepository ,Microsatellite ,Sample integrity ,business ,Quality assurance ,Microsatellite Repeats - Abstract
Quality assurance and quality control (QA/QC) procedures are vital to good biorepository management. The National Eye Institute (NEI) core CLIA-certified laboratory of the eyeGENE(®) Network receives blood from individuals with inherited eye conditions and isolates DNA for clinical genetic diagnostic testing and research. Clinical genetic test results are returned to the affected individuals, making it imperative that sample integrity is preserved throughout laboratory processing. A clinically validated, short tandem repeat (STR)-based approach, termed Sample Confirmation Testing (SCT), was developed to ensure that no significant laboratory errors occurred during processing. SCT uses modified protocols from commercial kits to create and compare STR profiles for each participant's original blood and derived DNA. This QA/QC procedure has been performed on 47% of the more than 6000 participants in the eyeGENE Biorepository and has identified significant laboratory errors in 0.4% of samples tested. SCT improves the quality of the data returned to affected individuals and the data distributed to researchers using eyeGENE samples by ensuring the integrity of the samples and aiding in curation of the biorepository. This approach serves as a model for other repositories to improve sample quality and management procedures.
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- 2016
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224. Insulin degludec in the first trimester of pregnancy: Report of two cases
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Riccardo Vigneri, Andrea Tumminia, Lucia Frittitta, Agostino Milluzzo, Laura Sciacca, and Nunzio Massimo Scalisi
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Insulin degludec ,medicine.medical_specialty ,Pediatrics ,Congenital abnormalities ,Diabetes mellitus ,Insulin ,Neonatal intensive care unit ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Insulin analog ,Case Report ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Hypoglycemia ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,medicine ,Type 1 diabetes ,Pregnancy ,business.industry ,Articles ,General Medicine ,medicine.disease ,Clinical Science and Care ,Endocrinology ,business - Abstract
Insulin degludec is an extra‐long‐acting insulin analog that allows for enhanced efficacy and flexibility in the injection time. However, it is not approved for use during pregnancy. We report the pregnancy outcome and newborn conditions in two women with type 1 diabetes who continued preconception degludec treatment during embryogenesis. No pregnancy complication or congenital neonatal malformation was observed. Both babies presented with hypoglycemia and required neonatal intensive care unit admission. Degludec treatment did not cause adverse effects in the mothers or malformations in the newborns. The observed neonatal complications were probably independent of early pregnancy degludec treatment.
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- 2017
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225. Ocular Surface – Merging Challenges and Opportunities
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David T. Yeung, Houmam Araj, and Santa J. Tumminia
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0301 basic medicine ,genetic structures ,Biomedical Engineering ,Exploratory research ,Light sensing ,mustard ,anterior segment ,vesicants ,Chemical exposure ,03 medical and health sciences ,0302 clinical medicine ,Animal model ,Anterior Eye Segment ,Animals ,Humans ,toxicity ,Medical research ,United States ,eye diseases ,Posterior segment of eyeball ,Ophthalmology ,030104 developmental biology ,Perspective ,030221 ophthalmology & optometry ,Optometry ,Vascular pathology ,countermeasure ,Ocular surface - Abstract
Dichotomies are double-edged: they can simplify and enlighten as well as exaggerate and entangle. Seeing the eye as anterior segment vs. posterior segment simplifies the formidable task of dissecting the function of the eye. Yet this view creates artificial divisions in a coherent whole. Clearly, vision requires the convergence of the light refractive function of the front of the eye with the light sensing function of the back of the eye. The National Eye Institute has long aimed to foster research across the visual pathway. Finding the right balance is a constant work in progress. A recently held scientific meeting which we co-organized with the United States Army Medical Research Institute of Chemical Defense, offered an opportunity to take stock of what the anterior segment in general, and the ocular surface in particular, bring to our understanding of biology and disease of the eye. Multiple dichotomies surfaced: acute vs. chronic disease; epithelial vs. endothelial damage; fibrotic vs. vascular pathology; inflammation vs. resolution response; chemical exposure vs. countermeasure; monotherapy vs. combination therapy; mechanistic vs. exploratory research; human vs. animal model. Merging some of these dichotomies is the goal of this paper.
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- 2020
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226. Impact of unhealthy childhood and unfavorable parents' characteristics on adiposity in schoolchildren
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Roberto Baratta, Luana Catena Romeo, Cristina Parrino, Nadia La Spina, Francesca Roppolo, Lucia Frittitta, Andrea Tumminia, Federica Vinciguerra, Laura Sciacca, and Riccardo Vigneri
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Male ,Parents ,Pediatric Obesity ,Endocrinology, Diabetes and Metabolism ,Health Behavior ,Carbonated Beverages ,030204 cardiovascular system & hematology ,Overweight ,Body Mass Index ,Cohort Studies ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Surveys and Questionnaires ,Prevalence ,Child ,Sicily ,Adiposity ,Waist-to-height ratio ,unhealthy habits ,Anthropometry ,Prognosis ,Female ,parental risk factors ,medicine.symptom ,Waist Circumference ,childhood obesity ,Waist ,Adolescent ,030209 endocrinology & metabolism ,Childhood obesity ,03 medical and health sciences ,Screen time ,Internal Medicine ,medicine ,Humans ,Exercise ,business.industry ,Odds ratio ,medicine.disease ,Obesity ,Diet ,Cross-Sectional Studies ,Socioeconomic Factors ,business ,Body mass index ,Demography ,Follow-Up Studies - Abstract
BACKGROUND Childhood obesity is encouraged by low physical activity (PA), time spent using screens (screen time, ST), and by sugar-sweetened beverage consumption (SSBc). It is also influenced by unfavorable parents' characteristics, such as a high body mass index (BMI) and low education level (EL). Our aim was to evaluate the overall and specific influence of these factors on childhood adiposity. MATERIAL AND METHODS Anthropometric parameters including BMI z-score, waist circumference (WC), waist to height ratio (WtHR), and fat mass were measured in a cohort of 1702 schoolchildren (6.0-14.5 years, mean 10.7 ± 1.8) and questionnaires concerning children's PA, ST, and SSBc, and parent's BMI and EL were administered to parents. RESULTS Overweight/obesity prevalence was higher (P
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- 2019
227. Guidelines for the screening and diagnosis of gestational diabetes in Italy from 2010 to 2019: critical issues and the potential for improvement
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Camilla Festa, Graziano Di Cianni, Francesco Purrello, Matteo Bonomo, C. Lencioni, Annunziata Lapolla, Elisabetta Torlone, Marina Scavini, Domenico Mannino, Angela Napoli, Andrea Tumminia, Elena Succurro, Antonino Di Benedetto, Giorgio Sesti, and Ester Vitacolonna
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Adult ,medicine.medical_specialty ,Maternal outcomes ,Diagnostic criteria ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Scopus ,MEDLINE ,030209 endocrinology & metabolism ,Scientific literature ,030204 cardiovascular system & hematology ,Macrosomia ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Pregnancy ,Internal Medicine ,medicine ,Humans ,Mass Screening ,Non-communicable diseases ,Mass screening ,Gestational diabetes ,Health professionals ,business.industry ,Diabetes ,Fetal outcomes ,Obesity prevention ,Diabetes, Gestational ,Female ,Italy ,Practice Guidelines as Topic ,General Medicine ,medicine.disease ,Family medicine ,Gestational ,business ,Risk assessment - Abstract
In 2010, Italian health professionals rapidly implemented the one-step screening for gestational diabetes mellitus (GDM) based on a 75 g OGTT, to comply with the diagnostic criteria proposed by the International Association of Diabetes and Pregnancy Study Groups (IADPSG). The change was promoted by the two main Italian scientific societies of diabetology, Associazione Medici Diabetologi (AMD) and Societa Italiana di Diabetologia (SID), and it took just a few months for the Istituto Superiore di Sanita, together with several scientific societies, to revise the criteria and include them in the National Guidelines System. Over the last 9 years, the implementation of these guidelines has shown some benefits and some drawbacks. In order to evaluate the critical issues arisen from the implementation of the current Italian guidelines for the diagnosis of GDM, the studies published on this topic have been reviewed. The search was performed using the following keywords: “gestational diabetes” AND “diagnostic criteria” OR screening AND Ital*. The study is an expert opinion paper, based on the relevant scientific literature published between 2010 and 2019. The databases screened for the literature review included PubMed, MEDLINE, and Scopus. The implementation of the Guidelines for Screening and Diagnosis of GDM in Italy present some strengths and some weaknesses. One of the positive aspects is that high-risk women are required to perform an OGTT early in pregnancy. By contrast, there are several aspects in need of improvement: (1) In spite of the current indications, only a minority of high-risk women perform OGTT early in pregnancy; (2) several low-risk women are screened for GDM; (3) in some low-risk women affected by GDM, the diagnosis might be missed with the application of the current guidelines; (4) there is a lack of homogeneity in the risk assessment data from different regions. In order to improve the current Italian GDM guidelines, some practical solutions have been suggested.
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- 2019
228. 0258 Early Semester Sleep Variability Predicts Depression Among College Students
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Janine M. Dutcher, David Creswell, Prerna Chikersal, Kasey G. Creswell, Afsaneh Doryab, Daniella K. Villalba, Michael J. Tumminia, Jennifer Mankoff, Anind K. Dey, S Price, and Sheldon Cohen
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business.industry ,Physiology (medical) ,Medicine ,Neurology (clinical) ,business ,Sleep in non-human animals ,Depression (differential diagnoses) ,Clinical psychology - Abstract
Introduction Sleep is a critical behavior predicting mental health and depressive symptomatology in young adults.The extant scientific literature generally focuses on self-reported sleep measures over relatively short time frames. Here, we examine whether actigraphy-measured sleep variables early in the academic semester predict depressive symptomatology at the end of the semester among first and second year college students. There is currently debate in the sleep literature about which sleep variables are the most robust predictors of depression among young adults. In this study, we evaluate total sleep time, midpoint sleep time, and sleep variability where variability is defined by the mean-squared successive difference (MSSD) of midpoint sleep as predictors of depression. Methods The sample consisted of 160 first and second year college students at a private American university. The students completed a beginning and end of semester assessment of depressive symptomatology using the Center for Epidemiologic Studies Depression Scale (CES-D), and wore a Fitbit throughout the semester to capture sleep features of interest: total sleep time (TST), midpoint sleep, and midpoint MSSD. Results When controlling for beginning of semester CES-D, early semester (weeks 3–6) midpoint sleep MSSD significantly (p < 0.05) predicted increased end of semester CES-D. These effects were specific to the sleep variability measure (MSSD). Total sleep time and sleep chronotype (i.e. midpoint sleep) were not significant predictors of end of semester depressive symptomatology. Conclusion Early semester sleep window variability among college freshmen, particularly during stressful midterm exams, is a robust risk factor for depression among college students. This work contributes to initial actigraphy studies suggesting that MSSD measures of sleep window variability foster increased mental health risks among young people. This work calls for further investigation to understand possible causal relationships between sleep variability and mental health. Support This work was supported by the Life@CMU project funded by the Carnegie Mellon University Provost’s Office.
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- 2020
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229. Identifying Behavioral Phenotypes of Loneliness and Social Isolation with Passive Sensing: Statistical Analysis, Data Mining and Machine Learning of Smartphone and Fitbit Data (Preprint)
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Afsaneh Doryab, Daniella K Villalba, Prerna Chikersal, Janine M Dutcher, Michael Tumminia, Xinwen Liu, Sheldon Cohen, Kasey Creswell, Jennifer Mankoff, John D Creswell, and Anind K Dey
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BACKGROUND Feelings of loneliness are associated with poor physical and mental health. Detection of loneliness through passive sensing on personal devices can lead to the development of interventions aimed at decreasing rates of loneliness. OBJECTIVE The aim of this study was to explore the potential of using passive sensing to infer levels of loneliness and to identify the corresponding behavioral patterns. METHODS Data were collected from smartphones and Fitbits (Flex 2) of 160 college students over a semester. The participants completed the University of California, Los Angeles (UCLA) loneliness questionnaire at the beginning and end of the semester. For a classification purpose, the scores were categorized into high (questionnaire score>40) and low (≤40) levels of loneliness. Daily features were extracted from both devices to capture activity and mobility, communication and phone usage, and sleep behaviors. The features were then averaged to generate semester-level features. We used 3 analytic methods: (1) statistical analysis to provide an overview of loneliness in college students, (2) data mining using the Apriori algorithm to extract behavior patterns associated with loneliness, and (3) machine learning classification to infer the level of loneliness and the change in levels of loneliness using an ensemble of gradient boosting and logistic regression algorithms with feature selection in a leave-one-student-out cross-validation manner. RESULTS The average loneliness score from the presurveys and postsurveys was above 43 (presurvey SD 9.4 and postsurvey SD 10.4), and the majority of participants fell into the high loneliness category (scores above 40) with 63.8% (102/160) in the presurvey and 58.8% (94/160) in the postsurvey. Scores greater than 1 standard deviation above the mean were observed in 12.5% (20/160) of the participants in both pre- and postsurvey scores. The majority of scores, however, fell between 1 standard deviation below and above the mean (pre=66.9% [107/160] and post=73.1% [117/160]). Our machine learning pipeline achieved an accuracy of 80.2% in detecting the binary level of loneliness and an 88.4% accuracy in detecting change in the loneliness level. The mining of associations between classifier-selected behavioral features and loneliness indicated that compared with students with low loneliness, students with high levels of loneliness were spending less time outside of campus during evening hours on weekends and spending less time in places for social events in the evening on weekdays (support=17% and confidence=92%). The analysis also indicated that more activity and less sedentary behavior, especially in the evening, was associated with a decrease in levels of loneliness from the beginning of the semester to the end of it (support=31% and confidence=92%). CONCLUSIONS Passive sensing has the potential for detecting loneliness in college students and identifying the associated behavioral patterns. These findings highlight intervention opportunities through mobile technology to reduce the impact of loneliness on individuals’ health and well-being.
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- 2018
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230. A Review of Work–Family Research in Western and Southern Europe
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Alexandra M. Tumminia and Rachel Omansky
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- 2018
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231. Short-term efficacy of high intensity group and individual education in patients with type 2 diabetes: a randomized single-center trial
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Lucia Frittitta, Andrea Tumminia, Roberto Baratta, N. La Spina, L. Romeo, L. Tomaselli, R. Reale, and Giuseppa Padova
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Blood Glucose ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,Single Center ,Diabetes Therapy ,law.invention ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Randomized controlled trial ,Patient Education as Topic ,law ,Diabetes mellitus ,Internal medicine ,Surveys and Questionnaires ,medicine ,Humans ,Glycemic ,Glycated Hemoglobin ,business.industry ,Middle Aged ,medicine.disease ,Prognosis ,Self Care ,Self-Help Groups ,Diabetes Mellitus, Type 2 ,Glycemic Index ,030220 oncology & carcinogenesis ,Cohort ,Quality of Life ,Female ,business ,Body mass index ,Follow-Up Studies - Abstract
The aim of this randomized study was to examine the efficacy of two high intensity educational programs: the conversation maps-based (CM™) education and the individual education (IE), compared to usual care (UC) in a cohort of type 2 diabetic (T2DM) patients. Ninety T2DM outpatients (30 per group) were randomized and 79 finished the study and were analyzed. The CM™ and IE groups received four educational sessions at 0, 4, 8 and 12 weeks, while the UC group received two brief individual sessions at 0 and 12 weeks. We evaluated glycemic control (HbA1c), diabetes treatment, body mass index (BMI) and carried out a questionnaire survey at three time points (before intervention, at 12 and at 32 weeks) to assess patients’ satisfaction, attitudes toward diabetes and dietary knowledge. All the three groups showed a significant and comparable reduction of both HbA1c and BMI. Diabetes therapy needed to be reinforced in a higher percentage of cases (39.3%) among UC patients compared to the IE (14.8%; p = 0.04) and the CM™ (8.3%; p = 0.01) groups. At 32 weeks Diabetes Treatment Satisfaction (DTSQ Q1 + Q4–8) significantly improved in the CM™ group (25.8 ± 4.5 vs. 22.4 ± 6.0; p
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- 2018
232. Quality Management: Institution of Incident Reporting in the Clinical Laboratory
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Ehsan Ullah, Melissa Reeves, Santa J. Tumminia, and Robert B. Hufnagel
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Equipment failure ,Quality management ,business.industry ,Institution (computer science) ,Operations management ,General Medicine ,Business ,Institutional review board ,Risk assessment ,Standard operating procedure ,Risk management - Abstract
Introduction Risk assessment is a critical part of quality management for a clinical laboratory. As a part of risk management, it is important to track any deviances from standard operating procedures (SOPs) and document equipment or assay failures consistently. Methods Our laboratory instituted an incident reporting system for reporting any deviances from protocol or equipment failures to track recurrent issues and determine if changes to protocols were necessitated. A guidance for completing the form was used so that the forms were completed in a standardized manner. Each incident is given a unique ID for tracking and identifies who discovered the incident and a secondary person that the incident was reported to at the time of occurrence. The incident is classified as Process, Instrument, Personnel, or Other and could be grouped into more than one category. The Other category includes incidents such as those involving reagent or equipment malfunctions. Incident reports are reviewed and discussed during the weekly lab meeting to determine the most appropriate category(s) for classification. Further, a fixed decision-making algorithm was applied to intervene specifically if the incident (a) was recurring, (b) required an SOP investigation or additional personnel training, and (c) needed to be reported to the institutional review board (IRB). Incidents are tracked until corrective action has been completed and reviewed periodically by the laboratory director. We reviewed the data after our first year of incident reporting to evaluate trends in incident categories. Results and Conclusion Forty-nine incidents were reported December 2017-2018. The highest classification categories included Other and a dual category, Process and Personnel, with 10 reports in each (40.8% overall). Twelve incidents were considered Recurring, 16 prompted SOP updates, and 1 was reported to the IRB. Through incident reporting, we were able to identify and resolve key risk areas in our procedures, which improved our operations and overall quality.
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- 2019
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233. Experimental and Computational Fluid Dynamic Study of an Active Ventilated Façade Integrating Battery and Distributed MPPT
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Ferraro, Marco, primary, Farulla, Girolama, additional, Tumminia, Giovanni, additional, Guarino, Francesco, additional, Aloisio, Davide, additional, Brunaccini, Giovanni, additional, Sergi, Francesco, additional, Giusa, Fabio, additional, Colino, Antonio, additional, Cellura, Maurizio, additional, and Antonucci, Vincenzo, additional
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- 2019
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234. Quality Management: Institution of Incident Reporting in the Clinical Laboratory
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Reeves, Melissa, primary, Ullah, Ehsan, additional, Hufnagel, Robert, additional, and Tumminia, Santa, additional
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- 2019
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235. Leveraging Routine Behavior and Contextually-Filtered Features for Depression Detection among College Students
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Xu, Xuhai, primary, Chikersal, Prerna, additional, Doryab, Afsaneh, additional, Villalba, Daniella K., additional, Dutcher, Janine M., additional, Tumminia, Michael J., additional, Althoff, Tim, additional, Cohen, Sheldon, additional, Creswell, Kasey G., additional, Creswell, J. David, additional, Mankoff, Jennifer, additional, and Dey, Anind K., additional
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- 2019
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236. Impact of unhealthy childhood and unfavorable parents' characteristics on adiposity in schoolchildren
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Vinciguerra, Federica, primary, Tumminia, Andrea, additional, Roppolo, Francesca, additional, Romeo, Luana Catena, additional, La Spina, Nadia, additional, Baratta, Roberto, additional, Parrino, Cristina, additional, Sciacca, Laura, additional, Vigneri, Riccardo, additional, and Frittitta, Lucia, additional
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- 2019
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237. Computer Fluid Dynamics Assessment of an Active Ventilated Façade Integrating Distributed MPPT and Battery
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Ferraro, Marco, primary, Farulla, Girolama, additional, Tumminia, Giovanni, additional, Guarino, Francesco, additional, Aloisio, Davide, additional, Brunaccini, Giovanni, additional, Sergi, Francesco, additional, Giusa, Fabio, additional, Colino, Antonio, additional, Cellura, Maurizio, additional, and Antonucci, Vincenzo, additional
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- 2019
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238. Adipose Tissue, Obesity and Adiponectin: Role in Endocrine Cancer Risk
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Tumminia, Andrea, primary, Vinciguerra, Federica, additional, Parisi, Miriam, additional, Graziano, Marco, additional, Sciacca, Laura, additional, Baratta, Roberto, additional, and Frittitta, Lucia, additional
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- 2019
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239. Short-term adverse effects of anticancer drugs in patients with type 2 diabetes
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Milluzzo, Agostino, primary, Tumminia, Andrea, additional, Vella, Veronica, additional, Gianì, Fiorenza, additional, Manzella, Livia, additional, Frittitta, Lucia, additional, Belfiore, Antonino, additional, Vigneri, Riccardo, additional, and Sciacca, Laura, additional
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- 2019
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240. Typhoid fever as a cause of opportunistic infection: case report
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Tumminia Salvatore, Infurnari Laura, Saporito Laura, Colomba Claudia, and Titone Lucina
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica subspecies enterica serotype typhi, which is acquired by ingestion of contaminated food and water. Each year the disease affects at least 16 million persons world-wide, most of whom reside in the developing countries of Southeast Asia and Africa. In Italy the disease is uncommon with a greater number of cases in Southern regions than in Northern ones. Case presentation We report on a 57-year-old Sri-Lankan male affected by typhoid fever, the onset of which was accompanied by oropharyngeal candidiasis. This clinical sign was due to a transient cell-mediated immunity depression (CD4+ cell count was 130 cells/mm3) probably caused by Salmonella typhi infection. Human immunodeficiency virus infection was ruled out. Diagnosis of typhoid fever was made by the isolation of Salmonella typhi from two consecutive blood cultures. The patient recovered after a ten days therapy with ciprofloxacin and his CD4+ cell count improved gradually until normalization within 3 weeks. Conclusion Our patient is the first reported case of typhoid fever associated with oropharyngeal candidiasis. This finding suggests a close correlation between Salmonella typhi infection and transitory immunodepression.
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- 2006
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241. An unusual presentation of diffuse sclerosing variant of papillary thyroid carcinoma
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Regalbuto, C., Tumminia, A., Malandrino, P., Salamone, S., and Pezzino, V.
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- 2010
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242. Three Distinct Stages of Lens Opacification in Transgenic Mice Expressing the HIV-1 Protease
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Tumminia, Santa J., Clark, John I., Richiert, Dawn M., Mitton, Kenneth P., Duglas-Tabor, Yvonne, Kowalak, Jeffrey A., Garland, Donita L., and Russell, Paul
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- 2001
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243. Fluorenyl derivatives of early transition elements: a synthetic and structural study
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Calderazzo, Fausto, Marchetti, Fabio, Moreno, Marta, Pampaloni, Guido, and Tumminia, Francesca
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- 2001
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244. Effetti clinici e placentari dell'iperglicemia in gravidanza in donne con diabete mellito
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Tumminia, Andrea
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Diabetes, Pregnancy, Placenta ,Area 06 - Scienze mediche - Abstract
Nelle donne diabetiche la placenta presenta delle alterazioni strutturali e funzionali potenzialmente correlabili a una disregolazione del sistema insulina/IGF che possono essere responsabili di un alterato trasporto di nutrienti al feto e di un aumentata crescita fetale. In queste donne la valutazione del sistema insulina/IGF placentare può fornire importanti informazioni sui meccanismi delle complicanze fetali/neonatali e materne e sulle patologie dell età evolutiva dei bambini nati da madre diabetica. Scopo dello studio è stato quello di valutare l effetto del compenso glicemico sulla placenta in termini di espressione di IR e IGF-1R e di valutare la fosforilazione recettoriale e la trasmissione del segnale intracellulare. Sono state studiate: 40 pazienti con gravidanza fisiologica, 20 pazienti con diabete gestazionale (GDM), 20 pazienti con diabete mellito tipo 1 (DMT1). Le pazienti con DMT1 hanno mostrato: una minore fosforilazione di AKT (0.6±0.1 UD) rispetto agli altri due gruppi (1.7±0.2 UD nel gruppo delle gravidanze fisiologiche; 1.9±0.6 UD nel gruppo GDM). Il dato permane anche se correggiamo i valori per la glicemia peri-parto. La deficitaria fosforilazione di AKT (e quindi una meno efficace attivazione della via metabolica), potrebbe essere implicata nella maggiore frequenza di macrosomia/LGA registrata nei neonati da madri con DMT1 (50%). Una simile tendenza è stata trovata quando, indipendentemente dalla diagnosi, le pazienti sono state divise in base alla presenza o meno della macrosomia: nelle placente delle donne con macrosomia la fosforilazione di AKT è risultata deficitaria rispetto alle placente delle donne senza macrosomia. Le pazienti con DMT1 hanno inoltre mostrato una maggiore fosforilazione di IGF-IR (3.6±0.6 UD) rispetto agli altri due gruppi (1.8±0.2 UD nel gruppo delle gravidanze fisiologiche; 2.9±0.8 UD nel gruppo GDM). Tale differenza significativa, però, scompare se correggiamo i valori per la glicemia peri-parto. Quindi tale maggiore fosforilazione potrebbe essere verosimilmente legata agli aumentati livelli di glicemia in acuto che si verificano nel periodo subito prima del parto. Ciò potrebbe significare che la fosforilazione di IGF-IR (rispetto a quella di IR) sia implicata nel determinismo di alcuni outcome neonatali sfavorevoli legati al periodo peri-parto (come ad esempio l ipoglicemia neonatale o la prematurità). Dall analisi di regressione lineare è emerso che l emoglobina glicata media del II e III trimestre correla positivamente con l espressione di AKT. Il peggiore compenso metabolico nelle fasi centrali della gravidanza potrebbe, quindi, condizionare la trasduzione del segnale intracellulare a valle del recettore insulinico. E inoltre emerso che il peso della placenta non correla con l espressione di IR, IGF-IR, ERK, AKT e con la loro fosforilazione nella placenta al momento del parto. Pertanto, potrebbero coesistere altri fattori in grado di influenzare la crescita della placenta. Tuttavia non si può escludere anche un ruolo di IR e IGF-IR dal momento che lo studio è stato effettuato a termine di gravidanza, mentre è possibile che tali recettori siano coinvolti in epoca gestazionale differente da quella finale. In letteratura è riportato che IR, IGF-IR e i loro ligandi sono importanti per la crescita placentare e fetale, ma i dati nelle donne diabetiche sono scarsi. Questo è il primo studio in cui vengono messi in relazione gli esiti sfavorevoli della gravidanza con l espressione e la fosforilazione di fattori di crescita a livello placentare.
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- 2018
245. Review of general suggestions on physical activity to prevent and treat gestational and pre-existing diabetes during pregnancy and in postpartum
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Stefano Balducci, C. Lencioni, A. Bertolotto, Angela Napoli, T. Marcone, N. Di Biase, Ester Vitacolonna, Basilio Pintaudi, Andrea Tumminia, and Alessandro Roberto Dodesini
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Adult ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Pregnancy in Diabetics ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,physical Activity ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Pregnancy ,Risk Factors ,Diabetes mellitus ,medicine ,Childbirth ,Humans ,Healthy Lifestyle ,Intensive care medicine ,Exercise ,Gestational diabetes ,Nutrition and Dietetics ,diabetes ,business.industry ,Postpartum Period ,Pregnancy Outcome ,nutritional and metabolic diseases ,Protective Factors ,medicine.disease ,female genital diseases and pregnancy complications ,Exercise Therapy ,Clinical trial ,Diabetes, Gestational ,exercise training ,Premature birth ,Gestation ,Anxiety ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
The aim of this review is to provide general suggestions on physical activity (PA) in pre-gestational and gestational diabetes mellitus (GDM) and encourage women to take part in safe and effective activities throughout pregnancy, in the absence of other contraindications. PA before and during pregnancy and in postpartum has many positive effects on the mother, as it could reduce the risk of GDM, excessive weight gain and lower back pain and also prevents, in the postpartum, diabetes mellitus. It may also reduce the duration of labour and complications at childbirth, fatigue, stress, anxiety and depression, thereby leading to an improved sense of wellbeing. Clinically, it is thought to help prevent preeclampsia and premature birth even though RCTs provide conflicting evidence with regard to the prevention of GDM. The main reason for this rests on the fact that the majority of clinical trials have not been able to replicate the preventive effect of PA on the onset of GDM, such as the different adherence of the patient to PA. Herein, we survey the literature regarding exercise and PA on GDM prevention and treatment as well as on clinical outcomes in pre-GDM in pregnancy. On the basis of the current literature, we also present a series of general recommendations and suggestions on PA and exercise training in pregnancy among both diabetic patients and those at risk for GDM.
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- 2018
246. Long-acting insulin analogs and cancer
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Andrea Tumminia, Sebastiano Squatrito, Laura Sciacca, Riccardo Vigneri, Lucia Frittitta, A. Belfiore, Veronica Vella, and Livia Manzella
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0301 basic medicine ,Blood Glucose ,Time Factors ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Clinical Decision-Making ,Medicine (miscellaneous) ,Insulin Glargine ,030209 endocrinology & metabolism ,Pharmacology ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Diabetes mellitus ,Hyperinsulinism ,Neoplasms ,Hyperinsulinemia ,medicine ,Diabetes Mellitus ,Animals ,Humans ,Hypoglycemic Agents ,Insulin detemir ,Nutrition and Dietetics ,biology ,business.industry ,Insulin glargine ,Insulin ,Incidence ,Cancer ,medicine.disease ,Insulin receptor ,030104 developmental biology ,Treatment Outcome ,biology.protein ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,medicine.drug - Abstract
Aims Hyperinsulinemia is a recognized risk factor for cancer and plays a major role for the increased cancer incidence in diabetic patients. Whether insulin analogs, and particularly long-acting analogs, worsen the pro-cancer effect of excess insulin is still controversial. Data synthesis In this paper we summarize the biological bases for the potential detrimental effect of long-acting analogs on cancer cells and review the in vitro and in vivo evidence on this issue. Because of their different molecular structure relative to native insulin, insulin analogs may activate the insulin receptor (IR) and the post receptor pathways differently. Most, but not all, in vitro evidence indicate that long-acting analogs may have a stronger mitogenic potency than insulin on cancer cells. Notably insulin glargine, the most studied long-acting analog, also has a higher affinity for the insulin-like growth factor (IGF)-1 receptor, a potent growth mediator. In vitro observations, however, may not reflect what occurs in vivo when analogs are metabolized to derivatives with a different mitogenic activity. Clinical studies, mostly retrospective and predominantly concerning glargine, provide contrasting results. The only perspective trial found no cancer increase in patients treated with glargine. All these studies, however, have severe weaknesses because of the insufficient evaluation of important factors such as dose administered, length of exposure, patient follow-up duration and site-specific cancer investigation. Moreover, whether cancer promotion is a long-acting analog class characteristic or a specific effect of a single agent is not clear. Conclusions In conclusion the carcinogenic risk of long-acting analogs, and specifically glargine, can be neither confirmed nor excluded. A personalized and shared decision, considering all the individual risk factors (metabolic and non-metabolic), is the suggestion for the clinician.
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- 2018
247. Abnormal 1-hour post-load glycemia during pregnancy impairs post-partum metabolic status: a single-center experience
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F Frasca, Laura Sciacca, F. Cinti, Andrea Tumminia, F. Tata, Agostino Milluzzo, Riccardo Vigneri, Miriam Parisi, and Lucia Frittitta
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Adult ,Blood Glucose ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Oral glucose tolerance test ,030204 cardiovascular system & hematology ,Single Center ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Metabolic Diseases ,Pregnancy ,Internal medicine ,Glucose Intolerance ,Type 2 diabetes mellitus ,medicine ,Humans ,Gestational diabetes ,Retrospective Studies ,Post partum ,Glycated Hemoglobin ,business.industry ,Obstetrics ,Postpartum Period ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Settore MED/13 - ENDOCRINOLOGIA ,Odds ratio ,Glucose Tolerance Test ,Prognosis ,medicine.disease ,Diabetes and Metabolism ,Diabetes, Gestational ,Increased risk ,Diabetes Mellitus, Type 2 ,Hyperglycemia ,Female ,business ,Abnormal glucose levels ,Biomarkers ,hormones, hormone substitutes, and hormone antagonists ,Follow-Up Studies - Abstract
Recent evidence indicates that people with normal glucose tolerance (NGT) but 1-h post-load plasma glucose (1-h OGTT) ≥ 155 mg/dl have an increased risk for developing Type 2 diabetes mellitus (T2DM), determining a new risk category with deeper metabolic impairment. The aim of this study was to identify, among women with gestational diabetes (GDM), which alterations at OGTT during pregnancy are more frequently associated with 1-h OGTT ≥ 155 mg/dl at post-partum examination. Among 297 women affected by GDM, we retrospectively evaluated 244 resulted NGT after delivery. Based on post-partum glucose levels at 1-h OGTT, these people were divided into 188 cases (77.0%) with 1-h OGTT
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- 2018
248. The risk stratification of adverse neonatal outcomes in women with gestational diabetes (STRONG) study
- Author
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Pintaudi, B, Fresa, R, Dalfrà, M, Dodesini, Ar, Vitacolonna, E, Tumminia, A, Sciacca, L, Lencioni, C, Marcone, T, Lucisano, G, Nicolucci, A, Bonomo, M, Napoli, A, Collaborators Napoli A, STRONG Study Collaborators., Bitterman, O, Festa, C, Cimino, E, Mion, E, Di Cianni, G, Milluzzo, A, Fraticelli, F, Cavuto, L, Ciriello, E, Lapolla, A, Grassi, A, Limone, P, Nuzzi, A, Masha, A, Grimaldi, L, Biglino, S, Ansaldi, E, Battezzati, M, Meregalli, G, De Mori, V, Berzi, D, Bossi, A, Baggi, V, Lovati, E, Quarleri, L, Romanelli, T, Clementi, S, Nicolao, I, Zambotti, F, Lombardi, S, Costa, S, Tommasi, C, Rancan, S, Lisato, G, Bordon, P, Turazzi, D, Mollo, F, Grimaldi, F, Tonutti, L, Agus, S, Falivene, Mr, Versari, G, Corsi, Livia, Delucchi, M, Ratto, L, Magotti, Mg, Frusca, T, Haddoub, S, Suprani, A, Mori, M, Vita, Mg, Biase, Nd, Bertolotto, A, Michele, A, Cristina, B, Lacaria, E, Guarino, E, Monaci, F, Dotta, F, Torlone, E, Lalli, C, di Loreto, C, Scarponi, M, Del Prete, A, Leotta, S, Coletta, I, Abbruzzese, S, Montani, V, Cannarsa, E, Contini, P, Vero, R, Oliverio, R, Scavini, M, Dozio, N, Imbergamo, Mp, Cordera, R, Affinito, L, Maggi, Daniela, Bordone, C, Fochesato, E, Pissarelli, A, Libera, E, Morano, S, Filardi, T, and Fallarino, M.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Overweight ,Fetal Macrosomia ,03 medical and health sciences ,endocrinology ,0302 clinical medicine ,Pregnancy ,Gestational diabetes, Neonatal outcomes, Obesity, Risk stratification ,Medicine ,Humans ,030212 general & internal medicine ,gestational diabetes ,neonatal outcomes ,obesity ,risk stratification ,internal medicine ,diabetes and metabolism ,Obesity ,Gestational diabetes ,Risk stratification ,Respiratory distress ,business.industry ,Obstetrics ,Neonatal hypoglycemia ,Diabetes ,Infant, Newborn ,Pregnancy Outcome ,Gestational age ,Infant ,General Medicine ,medicine.disease ,Newborn ,Diabetes, Gestational ,Neonatal outcomes ,Female ,Gestational ,Small for gestational age ,Maternal death ,medicine.symptom ,business - Abstract
To assess the risk of adverse neonatal outcomes in women with gestational diabetes (GDM) by identifying subgroups of women at higher risk to recognize the characteristics most associated with an excess of risk. Observational, retrospective, multicenter study involving consecutive women with GDM. To identify distinct and homogeneous subgroups of women at a higher risk, the RECursive Partitioning and AMalgamation (RECPAM) method was used. Overall, 2736 pregnancies complicated by GDM were analyzed. The main outcome measure was the occurrence of adverse neonatal outcomes in pregnancies complicated by GDM. Among study participants (median age 36.8 years, pre-gestational BMI 24.8 kg/m2), six miscarriages, one neonatal death, but no maternal death was recorded. The occurrence of the cumulative adverse outcome (OR 2.48, 95% CI 1.59–3.87), large for gestational age (OR 3.99, 95% CI 2.40–6.63), fetal malformation (OR 2.66, 95% CI 1.00–7.18), and respiratory distress (OR 4.33, 95% CI 1.33–14.12) was associated with previous macrosomia. Large for gestational age was also associated with obesity (OR 1.46, 95% CI 1.00–2.15). Small for gestational age was associated with first trimester glucose levels (OR 1.96, 95% CI 1.04–3.69). Neonatal hypoglycemia was associated with overweight (OR 1.52, 95% CI 1.02–2.27) and obesity (OR 1.62, 95% CI 1.04–2.51). The RECPAM analysis identified high-risk subgroups mainly characterized by high pre-pregnancy BMI (OR 1.68, 95% CI 1.21–2.33 for obese; OR 1.38 95% CI 1.03–1.87 for overweight). A deep investigation on the factors associated with adverse neonatal outcomes requires a risk stratification. In particular, great attention must be paid to the prevention and treatment of obesity.
- Published
- 2018
249. Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
- Author
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Rika Yuliwulandari, Lisa M. Wheatley, Andrea D. Dalton, Carolyn M. Hutter, Surakameth Mahasirimongkol, J. Steven Leeder, Simone P. Pinheiro, Teri A. Manolio, Ricardo Cibotti, Lauren A. Trepanier, Juan J.L. Lertora, Howard L. McLeod, Ming Ta Michael Lee, Cynthia Sung, Joshua C. Denny, Elizabeth J. Phillips, Mark I. Avigan, Michael Pacanowski, Lois La Grenade, Wen-Hung Chung, Neil H. Shear, Wimon Suwankesawong, Maja Mockenhaupt, Santa J. Tumminia, Mary Carrington, Robert L. Davis, Wasun Chantratita, Shuen-Iu Hung, David L. Veenstra, and Munir Pirmohamed
- Subjects
medicine.medical_specialty ,Pharmacology ,030226 pharmacology & pharmacy ,Article ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Necrosis ,0302 clinical medicine ,Predictive Value of Tests ,Genetic predisposition ,medicine ,Humans ,Pharmacology (medical) ,Genetic Predisposition to Disease ,Drug reaction ,Genetic Testing ,business.industry ,Incidence (epidemiology) ,Incidence ,Stevens johnson ,medicine.disease ,Dermatology ,Toxic epidermal necrolysis ,stomatognathic diseases ,Stevens-Johnson Syndrome ,Risk allele ,business - Abstract
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.
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- 2017
250. Changes in brain connectivity following exposure to bilateral eye movements
- Author
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Michael J. Tumminia, Francesco DePalma, Jessica I. Fleck, Robert J. Olsen, Abigail Vrabel, Shannon Miller, and John Berroa
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Eye Movements ,Brain activity and meditation ,Cognitive Neuroscience ,media_common.quotation_subject ,Individuality ,Experimental and Cognitive Psychology ,Audiology ,Electroencephalography ,Theta power ,050105 experimental psychology ,Functional Laterality ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Arts and Humanities (miscellaneous) ,Developmental and Educational Psychology ,medicine ,Contrast (vision) ,Humans ,0501 psychology and cognitive sciences ,media_common ,medicine.diagnostic_test ,05 social sciences ,Eye movement ,Brain ,Coherence (statistics) ,Absolute power ,Middle Aged ,Neuropsychology and Physiological Psychology ,Resting state eeg ,Female ,Nerve Net ,Psychology ,030217 neurology & neurosurgery - Abstract
The present research assessed how engaging in bilateral eye movements influences brain activity. Participants had their resting-state brain activity recorded with electroencephalography (EEG) before and after they performed 30 s of bilateral eye movements or a center-control manipulation. We assessed differences in change scores for absolute power and coherence between the eye-movement and center-control conditions. A main effect for handedness was present for EEG power in the theta and beta frequency bands, with inconsistent-handed participants displaying a greater increase than consistent-handed participants in both frequency bands. For theta, the increase in power for inconsistent handers was specific to participants in the bilateral eye-movement condition, whose increase in theta power exceeded the increase in theta power for consistent-handed participants regardless of condition. In contrast, for coherence, a main effect for condition was present for the delta frequency band, with participants in the control condition exhibiting a significant drop in posterior delta coherence pre to post. We suggest that the maintenance of posterior delta coherence over time may be an important factor in sustaining attention. Further, the malleability of EEG power for inconsistent-handed participants reveals the importance of individual-differences variables in the potential for behavioral manipulations to change brain activity.
- Published
- 2017
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