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To advance our understanding of the fuelling and feedback processes which power the Universe's most massive black holes, we require a significant increase in our knowledge of the molecular gas which exists in their immediate surroundings. However, the behaviour of this gas is poorly understood due to the difficulties associated with observing it directly. We report on a survey of 18 brightest cluster galaxies lying in cool cores, from which we detect molecular gas in the core regions of eight via carbon monoxide (CO), cyanide (CN) and silicon monoxide (SiO) absorption lines. These absorption lines are produced by cold molecular gas clouds which lie along the line of sight to the bright continuum sources at the galaxy centres. As such, they can be used to determine many properties of the molecular gas which may go on to fuel supermassive black hole accretion and AGN feedback mechanisms. The absorption regions detected have velocities ranging from -45 to 283 km s$^{-1}$ relative to the systemic velocity of the galaxy, and have a bias for motion towards the host supermassive black hole. We find that the CN N = 0 - 1 absorption lines are typically 10 times stronger than those of CO J = 0 - 1. This is due to the higher electric dipole moment of the CN molecule, which enhances its absorption strength. In terms of molecular number density CO remains the more prevalent molecule with a ratio of CO/CN $\sim 10$, similar to that of nearby galaxies. Comparison of CO, CN and HI observations for these systems shows many different combinations of these absorption lines being detected., Comment: Accepted for publication in MNRAS

The [C II]λ158 μm line is one of the strongest far-infrared (FIR) lines and an important coolant in the interstellar medium of galaxies that is accessible out to high redshifts. The excitation of [C II] is complex and can best be studied in detail at low redshifts. Here we report the discovery of the highest global [C II] excess with respect to the FIR luminosity in the nearby AGN host galaxy HE 1353−1917. This galaxy is exceptional among a sample of five targets because the AGN ionization cone and radio jet directly intercept the cold galactic disk. As a consequence, a massive multiphase gas outflow on kiloparsec scales is embedded in an extended narrow-line region. Because HE 1353−1917 is distinguished by these special properties from our four bright AGN, we propose that a global [C II] excess in AGN host galaxies could be a direct signature of a multiphase AGN-driven outflow with a high mass-loading factor.

The [C II]λ158 μm line is one of the strongest far-infrared (FIR) lines and an important coolant in the interstellar medium of galaxies that is accessible out to high redshifts. The excitation of [C II] is complex and can best be studied in detail at low redshifts. Here we report the discovery of the highest global [C II] excess with respect to the FIR luminosity in the nearby AGN host galaxy HE 1353−1917. This galaxy is exceptional among a sample of five targets because the AGN ionization cone and radio jet directly intercept the cold galactic disk. As a consequence, a massive multiphase gas outflow on kiloparsec scales is embedded in an extended narrow-line region. Because HE 1353−1917 is distinguished by these special properties from our four bright AGN, we propose that a global [C II] excess in AGN host galaxies could be a direct signature of a multiphase AGN-driven outflow with a high mass-loading factor.

In recent years, the outskirts of galaxy clusters have emerged as one of the new frontiers and unique laboratories for studying the growth of large scale structure in the universe. Modern cosmological hydrodynamical simulations make firm and testable predictions of the thermodynamic and chemical evolution of the X-ray emitting intracluster medium. However, recent X-ray and Sunyaev-Zeldovich effect observations have revealed enigmatic disagreements with theoretical predictions, which have motivated deeper investigations of a plethora of astrophysical processes operating in the virialization region in the cluster outskirts. Much of the physics of cluster outskirts is fundamentally different from that of cluster cores, which has been the main focus of X-ray cluster science over the past several decades. A next-generation X-ray telescope, equipped with sub-arcsecond spatial resolution over a large field of view along with a low and stable instrumental background, is required in order to reveal the full story of the growth of galaxy clusters and the cosmic web and their applications for cosmology., Comment: 10 pages, 3 figures, Science white paper submitted to the Astro2020 Decadal Survey

Gabriel Tremblay,1 Tim Holbrook,2 Gary Milligan,2 Corey L Pelletier,1 Petra Rietschel1 1Eisai Inc, Woodcliff Lake, NJ, USA; 2Adelphi Real World, Manchester, UKAims: Lenvatinib and sorafenib have been evaluated in separate Phase III placebo-controlled trials in patients with radioiodine-refractory differentiated thyroid cancer; however, no head-to-head comparative studies are available. We performed an indirect comparison of these agents using matching-adjusted indirect comparison (MAIC) to adjust for differences in baseline characteristics, a technique allowing comparison of two studies with patient-level data available for one but only aggregate data available for the other.Patients and methods: Individual patient data were available for the SELECT trial (lenvatinib versus placebo) whereas only published summary data were available for the DECISION trial (sorafenib versus placebo); therefore the SELECT data were adjusted to closely match the DECISION data. Data for patients in SELECT were assigned weights so that weighted mean baseline characteristics of the SELECT population matched those reported for DECISION. Adjusted hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS; corrected for crossover using rank-preserving structural failure time models) were calculated using weighted Cox regression models. Adjusted HRs were used to calculate indirect HRs with 95% confidence intervals (CIs).Results: Indirect treatment comparison using unadjusted clinical trial data resulted in an HR for PFS of 0.36 (95% CI 0.22–0.57) for lenvatinib versus sorafenib; MAIC resulted in an HR of 0.33 (95% CI 0.20–0.53), suggesting a statistically significantly superior PFS for lenvatinib. The HR for crossover-corrected OS for lenvatinib versus sorafenib was 0.77 (95% CI 0.44–1.35); MAIC resulted in an OS HR of 0.73 (95% CI 0.40–1.35).Conclusion: After adjusting for differences in baseline characteristics using MAIC, lenvatinib was associated with statistically significantly superior PFS compared with sorafenib in patients with radioiodine-refractory differentiated thyroid cancer. This suggests lenvatinib may provide superior efficacy compared with sorafenib for patients with radioiodine-refractory differentiated thyroid cancer. Keywords: indirect comparison, lenvatinib, overall survival, progression-free survival, radioiodine-refractory, sorafenib

We report the first results of the MURALES survey, a complete program of MUSE observations of nearby (z

Context. The strong asymmetry in the optical [O III] λ5007 emission line is one of the best signatures of active galactic nuclei (AGN) driven warm (∼104 K) ionized gas outflows on host galaxy scales. While large spectroscopic surveys such as the sloan digital sky survey (SDSS) have characterized the kinematics of [O III] for large samples of AGN, estimating the associated energetics requires spatially resolving these outflows with, for example, integral field unit (IFU) studies.\ud\udAims. As part of the Close AGN Reference Survey, we obtained spatially resolved IFU spectroscopy for a representative sample of 39 luminous type 1 AGN at 0.01 80% of the flux associated with a point-like source. We measured < 100 pc offsets in the spatial location of the outflow from the AGN nucleus using the spectro-astrometry technique for these sources. For the other 13 AGN, the [O III] wing emission is resolved and possibly extended on several kiloparsec scales.\ud\udConclusions. We conclude that [O III] wing emission can be compact or extended in an unbiased luminous AGN sample, where both cases are likely to appear. Electron density in the compact [O III] wing regions (median ne ∼ 1900 cm−3) is nearly a magnitude higher than in the extended ones (median ne ∼ 500 cm−3). The presence of spatially extended and compact [O III] wing emission is unrelated to the AGN bolometric luminosity and to inclination effects, which means other features such as time delays, or mechanical feedback (radio jets) may shape the ionized gas outflow properties.

The aim of this paper is to present an analysis of newly acquired X-ray observations of 16 extragalactic radio sources, listed in the Third Cambridge Revised (3CR) catalog, and not previously observed by Chandra. Observations were performed during Chandra Cycle 17, extending X-ray coverage for the 3CR extragalactic catalog up to $z$=1.5. Among the 16 targets, two lie at $z, Comment: 25 pages, 19 figures, 5 tables, pre-proof version, published on the Astrophysical Journal Supplement series

This paper presents the analysis of Chandra X-ray snapshot observations of a subsample of the extragalactic sources listed in the revised Third Cambridge radio catalog (3CR), previously lacking X-ray observations and thus observed during Chandra Cycle 15. This data set extends the current Chandra coverage of the 3CR extragalactic catalog up to redshift $z$=1.0. Our sample includes 22 sources consisting of one compact steep spectrum (CSS) source, three quasars (QSOs), and 18 FR\,II radio galaxies. As in our previous analyses, here we report the X-ray detections of radio cores and extended structures (i.e., knots, hotspots and lobes) for all sources in the selected sample. We measured their X-ray intensities in three energy ranges: soft (0.5--1 keV), medium (1--2 keV) and hard (2-7 keV) and we also performed standard X-ray spectral analysis for brighter nuclei. All radio nuclei in our sample have an X-ray counterpart. We also discovered X-ray emission associated with the eastern knot of 3CR\,154, with radio hotspots in 3CR\,41, 3CR\,54 and 3CR\,225B and with the southern lobe of 3CR\,107. Extended X-ray radiation around the nuclei 3CR\,293.1 and 3CR\,323 on a scale of few tens kpc was also found. X-ray extended emission, potentially arising from the hot gas in the intergalactic medium and/or due to the high energy counterpart of lobes, is detected for 3CR\,93, 3CR\,154, 3CR\,292 and 3CR\, 323 over a few hundreds kpc-scale. Finally, this work also presents an update on the state-of-the-art of Chandra and XMM-Newton observations for the entire 3CR sample., 25 pages, 6 tables, 27 figures, ApJS accepted for publication (pre-proof version)

Beth A Fordham,1 Cicely Kerr,1 Hayley M de Freitas,1 Andrew J Lloyd,1 Karissa Johnston,2 Corey L Pelletier,3 Gabriel Tremblay,3 Anna Forsythe,3 Bryan McIver,4 Ezra EW Cohen5 1ICON Patient Reported Outcomes, Oxford, UK; 2ICON Epidemiology, Toronto, ON, Canada; 3Eisai Inc., NJ, 4Moffitt Cancer Center, FL, 5University of California San Diego Moores Cancer Center, La Jolla, CA, USA Purpose: The aim of this study was to elicit utilities for radioactive iodine-refractory differentiated thyroid cancer (RR-DTC) and evaluate the impact of treatment response and toxicities on quality of life.Patients and methods: RR-DTC health states were developed based on data from a previous qualitative study and iterative review by clinical experts. Following piloting, health states underwent valuation by 100 members of the UK public during time trade-off interviews. Mean utilities and descriptive distribution statistics were calculated, and a logistic regression analysis was conducted.Results: The demographic characteristics of the study sample were generally reflective of the UK population. Clear differentiation in valuation between health states was observed. No response/stable disease had an adjusted utility value of 0.87, with a corresponding gain of +0.04 following a treatment response and a decline of –0.35 for disease progression. Adverse events were associated with utility decrements between –0.47 (grade III diarrhea) and –0.05 (grade I/II alopecia).Conclusion: The trade-off interviews derived utility weights show clear differentiation between RR-DTC health states in response to treatment. The values reported in this study are suitable for cost-effectiveness evaluations for new treatments in RR-DTC. Keywords: differentiated thyroid cancer, radioactive iodine-refractory, health-related quality of life, health utility, vignette