19,469 results on '"Tortora, A."'
Search Results
202. Acute pediatric encephalitis: etiology, course, and outcome of a 12-year single-center immunocompetent cohort
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Brisca, Giacomo, Marini, Chiara, Buratti, Silvia, Mariani, Marcello, Tortora, Domenico, Morana, Giovanni, Pirlo, Daniela, Romanengo, Marta, Cannizzaro, Giulia, Cordani, Ramona, Canzoneri, Francesca, Calevo, Maria Grazia, Nobili, Lino, Franciotta, Diego, Castagnola, Elio, Moscatelli, Andrea, and Mancardi, Maria Margherita
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- 2023
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203. REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer
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Boggi, Ugo, Kauffmann, Emanuele, Napoli, Niccolò, Barreto, S. George, Besselink, Marc G., Fusai, Giuseppe K., Hackert, Thilo, Abu Hilal, Mohammad, Marchegiani, Giovanni, Salvia, Roberto, Shrikhande, Shailesh V., Truty, Mark, Werner, Jens, Wolfgang, Christopher L., Bannone, Elisa, Capretti, Giovanni, Cattelani, Alice, Coppola, Alessandro, Cucchetti, Alessandro, De Sio, Davide, Di Dato, Armando, Di Meo, Giovanna, Fiorillo, Claudio, Gianfaldoni, Cesare, Ginesini, Michael, Hidalgo Salinas, Camila, Lai, Quirino, Miccoli, Mario, Montorsi, Roberto, Pagnanelli, Michele, Poli, Andrea, Ricci, Claudio, Sucameli, Francesco, Tamburrino, Domenico, Viti, Virginia, Addeo, Pietro F., Alfieri, Sergio, Bachellier, Philippe, Baiocchi, Gian Luca, Balzano, Gianpaolo, Barbarello, Linda, Brolese, Alberto, Busquets, Juli, Butturini, Giovanni, Caniglia, Fabio, Caputo, Damiano, Casadei, Riccardo, Chunhua, Xi, Colangelo, Ettore, Coratti, Andrea, Costa, Francesca, Crafa, Francesco, Dalla Valle, Raffaele, De Carlis, Luciano, de Wilde, Roeland F., Del Chiaro, Marco, Di Benedetto, Fabrizio, Di Sebastiano, Pierluigi, Dokmak, Safi, Hogg, Melissa, Egorov, Vyacheslav I., Ercolani, Giorgio, Ettorre, Giuseppe Maria, Falconi, Massimo, Ferrari, Giovanni, Ferrero, Alessandro, Filauro, Marco, Giardino, Alessandro, Grazi, Gian Luca, Gruttadauria, Salvatore, Izbicki, Jakob R, Jovine, Elio, Katz, Matthew, Keck, Tobias, Khatkov, Igor, Kiguchi, Gozo, Kooby, David, Lang, Hauke, Lombardo, Carlo, Malleo, Giuseppe, Massani, Marco, Mazzaferro, Vincenzo, Memeo, Riccardo, Miao, Yi, Mishima, Kohei, Molino, Carlo, Nagakawa, Yuichi, Nakamura, Masafumi, Nardo, Bruno, Panaro, Fabrizio, Pasquali, Claudio, Perrone, Vittorio, Rangelova, Elena, Liu, Rong, Romagnoli, Renato, Romito, Raffaele, Rosso, Edoardo, Schulick, Richard, Siriwardena, Ajith, Spampinato, Marcello Giuseppe, Strobel, Oliver, Testini, Mario, Troisi, Roberto Ivan, Uzunoglo, Faik G., Valente, Roberto, Veneroni, Luigi, Zerbi, Alessandro, Vicente, Emilio, Vistoli, Fabio, Vivarelli, Marco, Wakabayashi, Go, Zanus, Giacomo, Zureikat, Amer, Zyromski, Nicholas J., Coppola, Roberto, D’Andrea, Vito, Davide, José, Dervenis, Christos, Frigerio, Isabella, Konlon, Kevin C., Michelassi, Fabrizio, Montorsi, Marco, Nealon, William, Portolani, Nazario, Sousa Silva, Donzília, Bozzi, Giuseppe, Ferrari, Viviana, Trivella, Maria G., Cameron, John, Clavien, Pierre-Alain, Asbun, Horacio J., Boraschi, Piero, Campani, Daniela, Cappelli, Carla, Cioni, Roberto, Dominici, Massimo, Esposito, Irene, Gambacorta, Maria A, Marciano, Emanuele, Masi, Gianluca, Morganti, Alessio, Mutignani, Massimiliano, Neri, Emanuele, Paiar, Fabiola, Reni, Michele, Rotondo, Maria Isabella, Silvestris, Nicola, Tortora, Giampaolo, Vasile, Enrico, and Volterrani, Duccio
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- 2024
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204. Author Correction: Evidence for multi-fragmentation and mass shedding of boulders on rubble-pile binary asteroid system (65803) Didymos
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M. Pajola, F. Tusberti, A. Lucchetti, O. Barnouin, S. Cambioni, C. M. Ernst, E. Dotto, R. T. Daly, G. Poggiali, M. Hirabayashi, R. Nakano, E. Mazzotta Epifani, N. L. Chabot, V. Della Corte, A. Rivkin, H. Agrusa, Y. Zhang, L. Penasa, R.-L. Ballouz, S. Ivanovski, N. Murdoch, A. Rossi, C. Robin, S. Ieva, J. B. Vincent, F. Ferrari, S. D. Raducan, A. Campo-Bagatin, L. Parro, P. Benavidez, G. Tancredi, Ö. Karatekin, J. M. Trigo-Rodriguez, J. Sunshine, T. Farnham, E. Asphaug, J. D. P. Deshapriya, P. H. A. Hasselmann, J. Beccarelli, S. R. Schwartz, P. Abell, P. Michel, A. Cheng, J. R. Brucato, A. Zinzi, M. Amoroso, S. Pirrotta, G. Impresario, I. Bertini, A. Capannolo, S. Caporali, M. Ceresoli, G. Cremonese, M. Dall’Ora, I. Gai, L. Gomez Casajus, E. Gramigna, R. Lasagni Manghi, M. Lavagna, M. Lombardo, D. Modenini, P. Palumbo, D. Perna, P. Tortora, M. Zannoni, and G. Zanotti
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Science - Published
- 2024
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205. Author Correction: The geology and evolution of the Near-Earth binary asteroid system (65803) Didymos
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Olivier Barnouin, Ronald-Louis Ballouz, Simone Marchi, Jean-Baptiste Vincent, Harrison Agrusa, Yun Zhang, Carolyn M. Ernst, Maurizio Pajola, Filippo Tusberti, Alice Lucchetti, R. Terik Daly, Eric Palmer, Kevin J. Walsh, Patrick Michel, Jessica M. Sunshine, Juan L. Rizos, Tony L. Farnham, Derek C. Richardson, Laura M. Parro, Naomi Murdoch, Colas Q. Robin, Masatoshi Hirabayashi, Tomas Kahout, Erik Asphaug, Sabina D. Raducan, Martin Jutzi, Fabio Ferrari, Pedro Henrique Aragao Hasselmann, Adriano CampoBagatin, Nancy L. Chabot, Jian-Yang Li, Andrew F. Cheng, Michael C. Nolan, Angela M. Stickle, Ozgur Karatekin, Elisabetta Dotto, Vincenzo Della Corte, Elena Mazzotta Epifani, Alessandro Rossi, Igor Gai, Jasinghege Don Prasanna Deshapriya, Ivano Bertini, Angelo Zinzi, Josep M. Trigo-Rodriguez, Joel Beccarelli, Stavro Lambrov Ivanovski, John Robert Brucato, Giovanni Poggiali, Giovanni Zanotti, Marilena Amoroso, Andrea Capannolo, Gabriele Cremonese, Massimo Dall’Ora, Simone Ieva, Gabriele Impresario, Michèle Lavagn, Dario Modenini, Pasquale Palumbo, Davide Perna, Simone Pirrotta, Paolo Tortora, Marco Zannoni, and Andrew S. Rivkin
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Science - Published
- 2024
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206. DNA Replication and Polymer Chain Duplication Reshape the Genome in Space and Time
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Dario D’Asaro, Maxime M. C. Tortora, Cédric Vaillant, Jean-Michel Arbona, and Daniel Jost
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Physics ,QC1-999 - Abstract
In eukaryotes, DNA replication constitutes a complex process whereby multiple origins are stochastically fired, and from which the replication machinery proceeds along chromosomes to achieve the faithful synthesis of two identical copies of the genome during the S phase of the cell cycle. Experimental evidence shows a functional correlation between the dynamics of replication and the spatial organization of the genome inside cell nuclei, suggesting that the process of replicating DNA may impact chromosome folding. However, the theoretical and mechanistic bases of such a hypothesis remain elusive. To address that question, we propose a quantitative, minimal framework that integrates the dynamics of replication along a polymer chain by accounting explicitly for the progression of the replication machinery and the resulting formation of sister chromatids. By systematically characterizing the 3D structural consequences of replication, and of possible interactions between active replication machineries, we show that the formation of transient loops may potentially impact chromosome organization across multiple temporal and spatial scales, from the level of individual origins to that of the global polymer chain. Comparison with available microscopy and chromosome conformation capture data in yeast suggests that a replication-dependent loop extrusion process may be acting in vivo, and may shape chromosomes as loose polymer bottle brushes during the S phase. Lastly, we explore the postreplication relative organization of sister chromatids and demonstrate the emergence of catenations and intertwined structures, which are regulated by the density of fired origins.
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- 2024
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207. A Task-oriented Multimodal Conversational Interface for a CSCW Immersive Virtual Environment.
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Paola Barra, Andrea Antonio Cantone, Rita Francese, Marco Giammetti, Raffaele Sais, Otino Pio Santosuosso, Aurelio Sepe, Simone Spera, Genoveffa Tortora, and Giuliana Vitiello
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- 2024
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208. Kinetically Constrained Quantum Dynamics in Superconducting Circuits
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Valencia-Tortora, Riccardo J., Pancotti, Nicola, and Marino, Jamir
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Disordered Systems and Neural Networks ,Quantum Physics - Abstract
We study the dynamical properties of the bosonic quantum East model at low temperature. We show that a naive generalization of the corresponding spin-1/2 quantum East model does not posses analogous slow dynamical properties. In particular, conversely to the spin case, the bosonic ground state turns out to be not localized. We restore localization by introducing a repulsive interaction term. The bosonic nature of the model allows us to construct rich families of many-body localized states, including coherent, squeezed and cat states. We formalize this finding by introducing a set of superbosonic creation-annihilation operators which satisfy the bosonic commutation relations and, when acting on the vacuum, create excitations exponentially localized around a certain site of the lattice. Given the constrained nature of the model, these states retain memory of their initial conditions for long times. Even in the presence of dissipation, we show that quantum information remains localized within decoherence times tunable with the parameters of the system. We propose an implementation of the bosonic quantum East model based on state-of-the-art superconducting circuits, which could be used in the near future to explore dynamical properties of kinetically constrained models in modern platforms., Comment: 26 pages, 18 figures; improved Sec. IV, V and VI
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- 2021
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209. Astraeus V: The emergence and evolution of metallicity scaling relations during the Epoch of Reionization
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Ucci, Graziano, Dayal, Pratika, Hutter, Anne, Kobayashi, Chiaki, Gottloeber, Stefan, Yepes, Gustavo, Hunt, Leslie, Legrand, Laurent, and Tortora, Crescenzo
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Astrophysics - Astrophysics of Galaxies - Abstract
In this work, we have implemented a detailed physical model of galaxy chemical enrichment into the ${\it Astraeus}$ (semi-numerical rAdiative tranSfer coupling of galaxy formaTion and Reionization in N-body dark matter simUlationS) framework which couples galaxy formation and reionization in the first billion years. Simulating galaxies spanning over 2.5 orders of magnitude in halo mass with $M_h \sim 10^{8.9-11.5} M_\odot$ ($M_h \sim 10^{8.9-12.8} M_\odot$) at $z \sim 10 ~ (5)$, we find: (i) smooth-accretion of metal-poor gas from the intergalactic medium (IGM) plays a key role in diluting the interstellar medium (ISM) metallicity which is effectively restored due to self-enrichment from star formation; (ii) a redshift averaged gas-mass loading factor that depends on the stellar mass as $\eta_g \approx 1.38 ({M_*}/{10^{10} M_\odot})^{-0.43}$; (iii) the mass-metallicity relation is already in place at $z \sim 10$ and shows effectively no redshift evolution down to $z \sim 5$; (iv) for a given stellar mass, the metallicity decreases with an increase in the star formation rate (SFR); (v) the key properties of the gas-phase metallicity (in units of 12+log(O/H), stellar mass, SFR and redshift are linked through a high-redshift fundamental plane of metallicity (HFPZ) for which we provide a functional form; (vi) the mass-metallicity-SFR relations are effectively independent of the reionization radiative feedback model for $M_* \geq 10^{6.5} M_\odot$ galaxies; (vii) while low-mass galaxies ($M_h \leq 10^9 M_\odot$) are the key contributors to the metal budget of the IGM at early times, higher mass halos provide about 50% of the metal budget at lower-redshifts., Comment: Accepted to MNRAS
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- 2021
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210. GAlaxy Light profile convolutional neural NETworks (GaLNets). I. fast and accurate structural parameters for billion galaxy samples
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Li, R., Napolitano, N. R., Roy, N., Tortora, C., La Barbera, F., Sonnenfeld, A., Qiu, C., and Liu, S.
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Astrophysics - Astrophysics of Galaxies - Abstract
Next generation large sky surveys will observe up to billions of galaxies for which basic structural parameters are needed to study their evolution. This is a challenging task that, for ground-based observations, is complicated by seeing limited point-spread function (PSF). To perform a fast and accurate analysis of galaxy surface brightness, we have developed a family of supervised Convolutional Neural Networks (CNN) to derive Sersic profile parameters of galaxies. This work presents the first two Galaxy Light profile convolutional neural Networks (GaLNets) of this family. The first one is trained using galaxy images only (GaLNet-1), and the second is trained with both galaxy images and the local PSF (GaLNet-2). We have compared the results from the GaLNets with structural parameters (total magnitude, effective radius, Sersic index etc.) derived on a set of galaxies from the Kilo-Degree Survey (KiDS) by 2DPHOT, as a representative of "standard" PSF convolved Sersic fitting tools. The comparison shows that GaLNet-2 can reach an accuracy as high as 2DPHOT, while GaLNet-1 performs worse because it misses the information on the local PSF. Both GaLNets are three orders of magnitude faster than standard methods in terms of computational speed. This first application of CNNs to ground-based galaxy surface photometry shows that they are promising tools to perform parametric analyses of very large galaxy samples, like the ones expected from Vera Rubin/LSST surveys. However, the GaLNets can be easily modified for space observations from Euclid and the China Space Station Telescope., Comment: Accepted for publication by APJ
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- 2021
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211. Precision tests of Quantum Mechanics and CPT symmetry with entangled neutral kaons at KLOE
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Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., D'Amico, R., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Diociaiuti, E., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E. A., Krzemien, W., Kupsc, A., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Passeri, A., Patera, V., del Rio, E. Perez, Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.
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High Energy Physics - Experiment - Abstract
The quantum interference between the decays of entangled neutral kaons is studied in the process $\phi\rightarrow K_S K_L \rightarrow\pi^+\pi^-\pi^+\pi^-$, which exhibits the characteristic Einstein--Podolsky--Rosen correlations that prevent both kaons to decay into $\pi^+\pi^-$ at the same time. This constitutes a very powerful tool for testing at the utmost precision the quantum coherence of the entangled kaon pair state, and to search for tiny decoherence and CPT violation effects, which may be justified in a quantum gravity framework. The analysed data sample was collected with the KLOE detector at DA$\Phi$NE, the Frascati $\phi$-factory, and corresponds to an integrated luminosity of about 1.7 fb$^{-1}$, i.e. to about $1.7 \times 10^9$ $\phi\rightarrow K_S K_L$ decays produced. From the fit of the observed $\Delta t$ distribution, being $\Delta t$ the difference of the kaon decay times, the decoherence and CPT violation parameters of various phenomenological models are measured with a largely improved accuracy with respect to previous analyses. The results are consistent with no deviation from quantum mechanics and CPT symmetry, while for some parameters the precision reaches the interesting level at which -- in the most optimistic scenarios -- quantum gravity effects might show up. They provide the most stringent limits up to date on the considered models., Comment: 17 pages 6 figures
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- 2021
212. Inferring galaxy dark halo properties from visible matter with Machine Learning
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von Marttens, Rodrigo, Casarini, Luciano, Napolitano, Nicola R., Wu, Sirui, Amaro, Valeria, Li, Rui, Tortora, Crescenzo, Canabarro, Askery, and Wang, Yang
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Astrophysics - Astrophysics of Galaxies - Abstract
Next-generation surveys will provide photometric and spectroscopic data of millions to billions of galaxies with unprecedented precision. This offers a unique chance to improve our understanding of the galaxy evolution and the unresolved nature of dark matter (DM). At galaxy scales, the density distribution of DM is strongly affected by the astrophysical feedback processes, which are difficult to fully account for in classical techniques to derive mass models. In this work, we explore the capability of supervised learning algorithms to predict the DM content of galaxies from luminous observational-like parameters, using the public catalog of the TNG100 simulation. In particular, we use Photometric, Structural and Kinematic parameters to predict the total DM mass, DM half-mass radius, DM mass inside one and two stellar half-mass radii. We adopt the coefficient of determination, $R^2$, as a reference metric to evaluate the accuracy of these predictions. We find that the Photometric features alone are able to predict the total DM mass with fair accuracy, while Structural and Photometric features together are more effective to determine the DM inside the stellar half mass radius, and the DM within twice the stellar half mass radius. However, using all observational quantities together (Photometry, Structural and Kinematics) incredibly improves the overall accuracy for all DM quantities. This first test shows that Machine Learning tools are promising approaches to derive predictions of the DM in real galaxies. The next steps will be to improve observational realism of the training sets, by closely select samples which accurately reproduce the typical observed luminous scaling relations. The trained pipelines will be suitable for real galaxy data collected from the next-generation surveys like Rubin/LSST, Euclid, CSST, 4MOST, DESI, to derive, e.g., the properties of their central DM fractions., Comment: 19 pages, 11 figures, 3 tables. Submitted to MNRAS. Comments are welcome
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- 2021
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213. The dark matter halo masses of elliptical galaxies as a function of observationally robust quantities
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Sonnenfeld, Alessandro, Tortora, Crescenzo, Hoekstra, Henk, Asgari, Marika, Bilicki, Maciej, Heymans, Catherine, Hildebrandt, Hendrik, Kuijken, Koen, Napolitano, Nicola R., Roy, Nivya, Valentijn, Edwin, and Wright, Angus H.
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Astrophysics - Astrophysics of Galaxies - Abstract
Context. The assembly history of the stellar component of a massive elliptical galaxy is closely related to that of its dark matter halo. Measuring how the properties of galaxies correlate with their halo mass can help understand their evolution. Aims. We investigate how the dark matter halo mass of elliptical galaxies varies as a function of their properties, using weak gravitational lensing observations. To minimise the chances of biases, we focus on galaxy properties that can be determined robustly: the surface brightness profile and the colour. Methods. We selected 2409 central massive elliptical galaxies from the SDSS spectroscopic sample. We first measured their surface brightness profile and colours by fitting Sersic models to photometric data from the Kilo-Degree Survey (KiDS). We fitted their halo mass distribution as a function of redshift, rest-frame $r-$band luminosity, half-light radius and rest-frame $u-g$ colour, using KiDS weak lensing data and a Bayesian hierarchical approach. For the sake of robustness to assumptions on the large-radii behaviour of the surface brightness, we repeated the analysis replacing total luminosity and half-light radius with the luminosity within a 10~kpc aperture, $L_{r,10}$, and the light-weighted surface brightness slope, $\Gamma_{10}$. Results. We did not detect any correlation between halo mass and either half-light radius or colour, at fixed redshift and luminosity. Conclusions. Our results indicate that the average star formation efficiency of massive elliptical galaxies has little dependence on their final size or colour. This suggests that the origin of the diversity in the size and colour distribution of these objects lies with properties other than halo mass., Comment: In press on Astronomy & Astrophysics. A short summary video is available at https://youtu.be/LlvwQNjLT7k
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- 2021
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214. Determination of uncertainty profiles in neutral atmospheric properties measured by radio occultation experiments
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Bourgoin, Adrien, Gramigna, Edoardo, Zannoni, Marco, Casajus, Luis Gomez, and Tortora, Paolo
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Astrophysics - Earth and Planetary Astrophysics ,General Relativity and Quantum Cosmology ,Physics - Atmospheric and Oceanic Physics - Abstract
Radio occultations are commonly used to assess remotely the thermodynamic properties of planets or satellites' atmospheres within the solar system. The data processing usually involves the so-called Abel inversion method or the numerical ray-tracing technique. Both these approaches are now well established, however, they do not allow to easily determine the uncertainty profiles in the atmospheric properties, and this makes the results difficult to interpret statistically. Recently, a purely analytical approach based on the time transfer functions formalism was proposed for modeling radio occultation data. Using this formulation, we derive uncertainty relationships between the frequency shift and the thermodynamic properties of the neutral atmosphere such as the temperature, pressure, and neutral number density. These expressions are important for interpreting previous results from past radio occultation experiments. They are especially relevant for deriving the system requirements for future missions in a rigorous manner and consistently with the scientific requirements about the atmospheric properties retrieval., Comment: 18 pages, 5 figures, 1 table
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- 2021
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215. SEAGLE--III: Towards resolving the mismatch in the dark-matter fraction in early-type galaxies between simulations and observations
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Mukherjee, Sampath, Koopmans, Léon V. E., Tortora, Crescenzo, Schaller, Matthieu, Metcalf, R. Benton, Schaye, Joop, and Vernardos, Georgios
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The central dark-matter fraction of galaxies is sensitive to feedback processes during galaxy formation. Strong gravitational lensing has been effective in the precise measurement of the dark-matter fraction inside massive early-type galaxies. Here, we compare the projected dark-matter fraction of early-type galaxies inferred from the SLACS strong-lens survey, with those obtained from the EAGLE, Illustris, and IllustrisTNG hydro-dynamical simulations. Previous comparisons with some simulations revealed a large discrepancy, with considerably higher inferred dark-matter fractions -- by factors 2-3 -- inside half of the effective radius in observed strong-lens galaxies as compared to simulated galaxies. Here, we report good agreement between EAGLE and SLACS for the dark-matter fractions inside both half of the effective radius and the effective radius as a function of the galaxy's stellar mass, effective radius, and total mass-density slope. However, for IllustrisTNG and Illustris, the dark-matter fractions are lower than observed. This work consistently assumes a Chabrier IMF, which suggests that a different IMF (although not excluded) is not necessary to resolve this mismatch. The differences in the stellar feedback model between EAGLE and Illustris and IllustrisTNG, are likely the dominant cause of the difference in their dark-matter fraction, and density slope., Comment: Matches with the published version. Fixed an error in Fig 2. Updated reference. Conclusions unchanged. 7 pages, 4 figures
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- 2021
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216. Scaling relations and baryonic cycling in local star-forming galaxies. III. Outflows, effective yields and metal loading factors
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Tortora, C., Hunt, L. K., and Ginolfi, M.
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Astrophysics - Astrophysics of Galaxies - Abstract
Gas accretion and stellar feedback processes link metal content, star formation, and gas and stellar mass (and the potential depth) in star-forming galaxies. Constraining this hypersurface has been challenging because of the need for measurements of HI and HII gas masses spanning a broad parameter space. A recent step forward has been achieved through the "Metallicity And Gas for Mass Assembly" (MAGMA) sample of local star-forming galaxies, which consists of homogeneously-determined parameters and a significant quantity of dwarf galaxies, with stellar masses as low as $\sim 10^5 - 10^{6}\, M_{\odot}$. Here, we adopt a "standard" galactic chemical evolution model, with which we can quantify stellar-driven outflows. In particular, we constrain the difference between the mass-loading in accretion and outflows and the wind metal-loading factor. The resulting model reproduces very well the local mass-metallicity relation, and the observed trends of metallicity with gas fraction. Although the difference in mass loading between accreted and expelled gas is extremely difficult to constrain, we find indications that, on average, the amount of gas acquired through accretion is roughly the same as the gas lost through bulk stellar outflows, corresponding to a "gas equilibrium" scenario. In agreement with previous work, the wind metal-loading factor shows a steep increase toward lower mass and circular velocity, indicating that low-mass galaxies are more efficient at expelling metals, thus shaping the mass-metallicity relation. Effective yields are found to increase with mass up to an inflection mass threshold, with a mild decline at larger masses and circular velocities. A comparison of our results for metal loading in outflows with the expectations for their mass loading favors momentum-driven winds at low masses, rather than energy-driven ones. (abridged), Comment: 21 pages, 13 figures, accepted for publication on A&A
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- 2021
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217. High-quality strong lens candidates in the final Kilo Degree survey footprint
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Li, R., Napolitano, N. R., Spiniello, C., Tortora, C., Kuijken, K., Koopmans, L. V. E., Schneider, P., Getman, F., Xie, L., Long, L., Shu, W., Vernardos, G., Huang, Z., Covone, G., Dvornik, A., Heymans, C., Hildebrandt, H., Radovich, M., and Wright, A. H.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present 97 new high-quality strong lensing candidates found in the final $\sim 350\,\rm deg^2$, that completed the full $\sim 1350\,\rm deg^2$ area of the Kilo-Degree Survey (KiDS). Together with our previous findings, the final list of high-quality candidates from KiDS sums up to 268 systems. The new sample is assembled using a new Convolutional Neural Network (CNN) classifier applied to $r$-band (best seeing) and $g,~r,~i$ color-composited images separately. This optimizes the complementarity of the morphology and color information on the identification of strong lensing candidates. We apply the new classifiers to a sample of luminous red galaxies (LRGs) and a sample of bright galaxies (BGs) and select candidates that received a high probability to be a lens from the CNN ($P_{\rm CNN}$). In particular, setting $P_{\rm CNN}>0.8$ for the LRGs, the $1$-band CNN predicts 1213 candidates, while the $3$-band classifier yields 1299 candidates, with only $\sim$30\% overlap. For the BGs, in order to minimize the false positives, we adopt a more conservative threshold, $P_{\rm CNN} >0.9$, for both CNN classifiers. This results in 3740 newly selected objects. The candidates from the two samples are visually inspected by 7 co-authors to finally select 97 "high-quality" lens candidates which received mean scores larger than 6 (on a scale from 0 to 10). We finally discuss the effect of the seeing on the accuracy of CNN classification and possible avenues to increase the efficiency of multi-band classifiers, in preparation of next-generation surveys from ground and space., Comment: Published by APJ
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- 2021
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218. Atezolizumab and chemotherapy for advanced or recurrent endometrial cancer (AtTEnd): a randomised, double-blind, placebo-controlled, phase 3 trial
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Zola, Paolo, Casanova, Claudia, Arcangeli, Valentina, Antonuzzo, Lorenzo, Gadducci, Angiolo, Cosio, Stefania, Clamp, Andrew, Persic, Mojca, McNeish, Ian, Tookman, Laura, Redondo Sanchez, Andrés, Choi, Chel Hun, Baldini, Editta, Palaia, Innocenza, Benedetti Panici, Pierluigi, Takahashi, Nobutaka, Lombard, Janine, Ardizzoia, Antonio, Bologna, Alessandra, Herrero Ibáñez, Ana Maria, Musolino, Antonino, Márquez Vázquez, Raúl, Pietzner, Klaus, Braicu, Elena, Heinzelmann-Schwarz, Viola A., Powell, Melanie, Yokoyama, Yoshihito, Baron-Hay, Sally, Abeni, Chiara, Martin Lorente, Cristina, Cueva, Juan Fernando, Trillsch, Fabian, Heitz, Florian, Ataseven, Beyhan, Petru, Edgar, Heubner, MartinLeonhard, Sadozye, Azmat Hassanq, Dubey, Sidharth, Tazbirkova, Andrea, Tiley, Susan, Chrystal, Kathryn, Kim, Sang Wun, Fehr, Mathias, Scatchard, Kate, Anand, Anjana, Taylor, Alexandra, Watary, Hidemichi, Enomoto, Takayuki, Yoshihara, Kosuke, Selva-Nayagam, Sudarsha, Karki, Bhaskar, Harrison, Michelle, Wilkinson, Kate, Goh, Jeffrey, Glasgow, Amanda, Chantrill, Lorraine, Lee, Chulmin, Bertolini, Alessandro, Narducci, Filomena, Bellotti, Giovanna, Fusco, Vittorio, Aebi, Stefan, Del Grande, Maria, Colombo, Ilaria, Tokunaga, Hideki, Shigeta, Shogo, Goss, Geraldine, Siow, Zhen Rong, Steer, Christopher, Lin, Hao, Lee, Kwang-Beom, Di Meglio, Giovanni, Massa, Elena, De Marino, Elvira, Tortora, Vincenzo, Palacio Vazquez, Isabel, Tsuji, Kosuke, Tominaga, Eiichiro, Black, Allison, So, Kyeong A, Suh, Dong Hoon, Lee, Keun Ho, Kim, Yong Man, Fossati, Roldano, Carlucci, Luciano, Barberis, Massimo, Torri, Valter, Santoni, Anna, Colombo, Nicoletta, Biagioli, Elena, Harano, Kenichi, Galli, Francesca, Hudson, Emma, Antill, Yoland, Rabaglio, Manuela, Marmé, Frederic, Marth, Christian, Parma, Gabriella, Fariñas-Madrid, Lorena, Nishio, Shin, Allan, Karen, Lee, Yeh Chen, Piovano, Elisa, Pardo, Beatriz, Nakagawa, Satoshi, McQueen, John, Zamagni, Claudio, Manso, Luis, Takehara, Kazuhiro, Tasca, Giulia, Ferrero, Annamaria, Tognon, Germana, Lissoni, Andrea Alberto, Petrella, Mariacristina, Laudani, Maria Elena, Rulli, Eliana, Uggeri, Sara, and Barretina Ginesta, M Pilar
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- 2024
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219. Germline pathogenic variants of cancer predisposition genes in a multicentre Italian cohort of pancreatic cancer patients.
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Orsi, Giulia, Carconi, Catia, Ghiorzo, Paola, Carrera, Paola, Pastorino, Lorenza, Presi, Silvia, Chiaravalli, Marta, Barbieri, Elena, Giordano, Guido, Sciallero, Stefania, Puccini, Alberto, Salvatore, Lisa, Cortesi, Laura, Macchini, Marina, Natalicchio, Maria Iole, Allavena, Eleonora, Pirrone, Chiara, Archibugi, Livia, Dalmasso, Bruna, Bruno, William, Tortora, Giampaolo, Landriscina, Matteo, Capurso, Gabriele, Cascinu, Stefano, Falconi, Massimo, and Reni, Michele
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- 2024
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220. Preoperative radiosurgery for brain metastases (PREOP-1): A feasibility trial
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Rogers, S, Schwyzer, L, Lomax, N, Alonso, S, Lazeroms, T, Gomez, S, Diahovets, K, Fischer, I, Schwenne, S, Ademaj, A, Berkmann, S, Tortora, A, Marbacher, S, Remonda, L, Schubert, G.A., and Riesterer, O
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- 2024
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221. The Hera Radio Science Experiment at Didymos
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Gramigna, Edoardo, Lasagni Manghi, Riccardo, Zannoni, Marco, Tortora, Paolo, Park, Ryan S., Tommei, Giacomo, Le Maistre, Sébastien, Michel, Patrick, Castellini, Francesco, and Kueppers, Michael
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- 2024
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222. Utility of virtual stenting in treatment of cerebral aneurysms by flow diverter devices
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Briganti, Francesco, Tortora, Mario, Loiudice, Giovanni, Tarantino, Margherita, Guida, Amedeo, Buono, Giuseppe, Marseglia, Mariano, Caranci, Ferdinando, and Tortora, Fabio
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- 2023
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223. A post-quantum key exchange protocol from the intersection of conics.
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Alberto Alzati, Daniele Di Tullio, Manoj Gyawali, and Alfonso Tortora
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- 2025
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224. Towards a muon collider
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Carlotta Accettura, Dean Adams, Rohit Agarwal, Claudia Ahdida, Chiara Aimè, Nicola Amapane, David Amorim, Paolo Andreetto, Fabio Anulli, Robert Appleby, Artur Apresyan, Aram Apyan, Sergey Arsenyev, Pouya Asadi, Mohammed Attia Mahmoud, Aleksandr Azatov, John Back, Lorenzo Balconi, Laura Bandiera, Roger Barlow, Nazar Bartosik, Emanuela Barzi, Fabian Batsch, Matteo Bauce, J. Scott Berg, Andrea Bersani, Alessandro Bertarelli, Alessandro Bertolin, Kevin Black, Fulvio Boattini, Alex Bogacz, Maurizio Bonesini, Bernardo Bordini, Salvatore Bottaro, Luca Bottura, Alessandro Braghieri, Marco Breschi, Natalie Bruhwiler, Xavier Buffat, Laura Buonincontri, Philip N. Burrows, Graeme Burt, Dario Buttazzo, Barbara Caiffi, Marco Calviani, Simone Calzaferri, Daniele Calzolari, Rodolfo Capdevilla, Christian Carli, Fausto Casaburo, Massimo Casarsa, Luca Castelli, Maria Gabriella Catanesi, Lorenzo Cavallucci, Gianluca Cavoto, Francesco Giovanni Celiberto, Luigi Celona, Alessandro Cerri, Gianmario Cesarini, Cari Cesarotti, Grigorios Chachamis, Antoine Chance, Siyu Chen, Yang-Ting Chien, Mauro Chiesa, Anna Colaleo, Francesco Collamati, Gianmaria Collazuol, Marco Costa, Nathaniel Craig, Camilla Curatolo, David Curtin, Giacomo Da Molin, Magnus Dam, Heiko Damerau, Sridhara Dasu, Jorge de Blas, Stefania De Curtis, Ernesto De Matteis, Stefania De Rosa, Jean-Pierre Delahaye, Dmitri Denisov, Haluk Denizli, Christopher Densham, Radovan Dermisek, Luca Di Luzio, Elisa Di Meco, Biagio Di Micco, Keith Dienes, Eleonora Diociaiuti, Tommaso Dorigo, Alexey Dudarev, Robert Edgecock, Filippo Errico, Marco Fabbrichesi, Stefania Farinon, Anna Ferrari, Jose Antonio Ferreira Somoza, Frank Filthaut, Davide Fiorina, Elena Fol, Matthew Forslund, Roberto Franceschini, Rui Franqueira Ximenes, Emidio Gabrielli, Michele Gallinaro, Francesco Garosi, Luca Giambastiani, Alessio Gianelle, Simone Gilardoni, Dario Augusto Giove, Carlo Giraldin, Alfredo Glioti, Mario Greco, Admir Greljo, Ramona Groeber, Christophe Grojean, Alexej Grudiev, Jiayin Gu, Chengcheng Han, Tao Han, John Hauptman, Brian Henning, Keith Hermanek, Matthew Herndon, Tova Ray Holmes, Samuel Homiller, Guoyuan Huang, Sudip Jana, Sergo Jindariani, Paul Bogdan Jurj, Yonatan Kahn, Ivan Karpov, David Kelliher, Wolfgang Kilian, Antti Kolehmainen, Kyoungchul Kong, Patrick Koppenburg, Nils Kreher, Georgios Krintiras, Karol Krizka, Gordan Krnjaic, Benjamin T. Kuchma, Nilanjana Kumar, Anton Lechner, Lawrence Lee, Qiang Li, Roberto Li Voti, Ronald Lipton, Zhen Liu, Shivani Lomte, Kenneth Long, Jose Lorenzo Gomez, Roberto Losito, Ian Low, Qianshu Lu, Donatella Lucchesi, Lianliang Ma, Yang Ma, Shinji Machida, Fabio Maltoni, Marco Mandurrino, Bruno Mansoulie, Luca Mantani, Claude Marchand, Samuele Mariotto, Stewart Martin-Haugh, David Marzocca, Paola Mastrapasqua, Giorgio Mauro, Andrea Mazzolari, Navin McGinnis, Patrick Meade, Barbara Mele, Federico Meloni, Matthias Mentink, Claudia Merlassino, Elias Metral, Rebecca Miceli, Natalia Milas, Nikolai Mokhov, Alessandro Montella, Tim Mulder, Riccardo Musenich, Marco Nardecchia, Federico Nardi, Niko Neufeld, David Neuffer, Daniel Novelli, Yasar Onel, Domizia Orestano, Daniele Paesani, Simone Pagan Griso, Mark Palmer, Paolo Panci, Giuliano Panico, Rocco Paparella, Paride Paradisi, Antonio Passeri, Nadia Pastrone, Antonello Pellecchia, Fulvio Piccinini, Alfredo Portone, Karolos Potamianos, Marco Prioli, Lionel Quettier, Emilio Radicioni, Raffaella Radogna, Riccardo Rattazzi, Diego Redigolo, Laura Reina, Elodie Resseguie, Jürgen Reuter, Pier Luigi Ribani, Cristina Riccardi, Lorenzo Ricci, Stefania Ricciardi, Luciano Ristori, Tania Natalie Robens, Werner Rodejohann, Chris Rogers, Marco Romagnoni, Kevin Ronald, Lucio Rossi, Richard Ruiz, Farinaldo S. Queiroz, Filippo Sala, Jakub Salko, Paola Salvini, Ennio Salvioni, Jose Santiago, Ivano Sarra, Francisco Javier Saura Esteban, Jochen Schieck, Daniel Schulte, Michele Selvaggi, Carmine Senatore, Abdulkadir Senol, Daniele Sertore, Lorenzo Sestini, Varun Sharma, Vladimir Shiltsev, Jing Shu, Federica Maria Simone, Rosa Simoniello, Kyriacos Skoufaris, Massimo Sorbi, Stefano Sorti, Anna Stamerra, Steinar Stapnes, Giordon Holtsberg Stark, Marco Statera, Bernd Stechauner, Daniel Stolarski, Diktys Stratakis, Shufang Su, Wei Su, Olcyr Sumensari, Xiaohu Sun, Raman Sundrum, Maximilian J. Swiatlowski, Alexei Sytov, Tim M. P. Tait, Jingyu Tang, Jian Tang, Andrea Tesi, Pietro Testoni, Brooks Thomas, Emily Anne Thompson, Riccardo Torre, Ludovico Tortora, Luca Tortora, Sokratis Trifinopoulos, Ilaria Vai, Marco Valente, Riccardo Umberto Valente, Alessandro Valenti, Nicolò Valle, Ursula van Rienen, Rosamaria Venditti, Arjan Verweij, Piet Verwilligen, Ludovico Vittorio, Paolo Vitulo, Liantao Wang, Hannsjorg Weber, Mariusz Wozniak, Richard Wu, Yongcheng Wu, Andrea Wulzer, Keping Xie, Akira Yamamoto, Yifeng Yang, Katsuya Yonehara, Sangsik Yoon, Angela Zaza, Xiaoran Zhao, Alexander Zlobin, Davide Zuliani, and Jose Zurita
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work.
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- 2023
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225. Prognostic analysis and outcomes of metastatic pancreatic cancer patients receiving nab‐paclitaxel plus gemcitabine as second or later‐line treatment
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Guido Giordano, Michele Milella, Matteo Landriscina, Francesca Bergamo, Giuseppe Tirino, Antonio Santaniello, Alberto Zaniboni, Enrico Vasile, Ferdinando De Vita, Giovanni Lo Re, Vanja Vaccaro, Elisa Giommoni, Donato Natale, Raffaele Conca, Daniele Santini, Luigi Maiorino, Gianni Sanna, Vincenzo Ricci, Aldo Iop, Vincenzo Montesarchio, Letizia Procaccio, Silvia Noventa, Roberto Bianco, Antonio Febbraro, Sara Lonardi, Giampaolo Tortora, Isabella Sperduti, and Davide Melisi
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FOLFIRINOX ,gemcitabine ,nab‐paclitaxel ,pancreatic cancer ,prognostic model ,second‐line chemotherapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Pancreatic cancer (PC) first‐line therapy often consists of polychemotherapy regimens, but choosing a second‐line therapy after disease progression, especially following first‐line FOLFIRINOX, remains a clinical challenge. This study presents results from a large, multicenter, retrospective analysis of Italian patients with metastatic PC (mPC) treated with Nab‐paclitaxel/Gemcitabine (AG) as second or later line of treatment. Main objective of the study is to identify prognostic factors that could inform treatment decisions. Methods The study included 160 mPC patients treated with AG in 17 Italian institutions. AG was administered according to labelling dose, until disease progression, unacceptable toxicity or patient refusal. Variations in schedules, dose modifications, supportive measures, and response evaluation were determined by individual clinicians' practice. Results AG was well‐tolerated and exhibited promising clinical activity. The overall response rate (ORR) and the disease control rate (DCR) were 22.5% and 45.6%, respectively. Median progression‐free survival (PFS) and overall survival (OS) were 3.9 and 6.8 months, respectively. Among the patients who received AG as a second‐line therapy (n = 111, 66.9%), median PFS and OS were 4.2 and 7.4 months, respectively. Notably, in the 76 patients (68%) receiving AG after first‐line FOLFIRINOX, an ORR of 19.7% and a DCR of 46.0% were observed, resulting in a median PFS of 3.5 and median OS of 5.7 months. The study identified specific clinical or laboratory parameters (LDH, NLR, fasting serum glucose, liver metastases, ECOG PS, and first‐line PFS) as independent prognostic factors at multivariate level. These factors were used to create a prognostic nomogram that divided patients into three risk classes, helping to predict second‐line OS and PFS. Conclusions This study represents the largest real‐world population of mPC patients treated with AG as a second or later line of therapy. It supports the feasibility of this regimen following first‐line FOLFIRINOX, particularly in patients with specific clinical and laboratory characteristics who derived prolonged benefit from first‐line therapy.
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- 2024
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226. Morphological and chemical changes in nuclear graphite target under vacuum and high-temperature conditions
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Stefania De Rosa, Elisabetta Colantoni, Paolo Branchini, Domizia Orestano, Antonio Passeri, Gianlorenzo Bussetti, Lisa Centofante, Stefano Corradetti, Martina Marsotto, Chiara Battocchio, Cristina Riccucci, and Luca Tortora
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Nuclear graphite ,High-energy reactions ,EDM ,HTR ,MSR ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Nuclear-grade graphite is a high-efficiency material, widely used for vacuum applications in nuclear reactors and accelerators as targets facing particle beams. In these contexts, graphite is often exposed to extreme thermal stresses altering its physical and chemical properties. The thermal-induced release of volatile contaminants from targets and the damage of structural components are critical issues that can affect the safety and operation efficiency of beamline facilities. Here, we provide for the first time a detailed picture of the chemical and morphological changes occurring in a nuclear-grade graphite target, obtained through Electrical Discharge Machining (EDM), when exposed in vacuum to high temperatures. The radial temperature gradient induced by the impact of a pulsed energetic (MeV- GeV range) focused particle beams was reproduced by cyclically heating, in the 1300–1800 K temperature range, a disc-shaped graphite target in a vacuum setup. An accurate surface and in-depth chemical analysis of the graphite target was obtained thanks to the high sensitivity (ppm/ppb) of the Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) technique. The chemical maps clearly show the presence of several metal oxides and impurities in the surface and subsurface regions of the untreated sample. Such contaminants were removed because of the thermal treatment in vacuum more or less efficiently, as demonstrated by Thermogravimetric analysis (TGA), X-ray Photoelectron Spectroscopy (XPS), and ToF-SIMS. However, Raman spectroscopy and SEM-EDS revealed that the high-temperature treatment induces a decrease in the crystallite size of the graphite as well as changes in the target surface porosity with the appearance of microvoids, leading the graphite target to be more prone to the breakage.
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- 2024
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227. Benefit of a multimodal approach combining chemotherapy and surgery in oligometastatic gastric cancer: experience from a tertiary referral center
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Maria Grazia Maratta, Antonio Vitale, Michele Basso, Raffaella Vivolo, Elena Di Monte, Alberto Biondi, Andrea Di Giorgio, Fausto Rosa, Vincenzo Tondolo, Annamaria Agnes, Giampaolo Tortora, Antonia Strippoli, and Carmelo Pozzo
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gastric cancer ,induction chemotherapy ,metastasectomy ,surgical oncology ,cancer survival ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionGastric cancer (GC) is the fourth leading cause of cancer-related death worldwide with limited therapeutic options. The aim of this study was to analyze the value of adding surgery to the first-line treatment in patients with oligometastatic GC (OGC).MethodsThis retrospective study included patients with OGC who underwent induction chemotherapy followed by surgery of both primary tumor and synchronous metastasis between April 2012 and April 2022. Endpoints were overall survival (OS) and relapse-free survival (RFS) analyzed by the Kaplan–Meier method. Prognostic factors were assessed with the Cox model.ResultsData from 39 patients were collected. All cases were referred to our multidisciplinary tumor board (MTB) to evaluate the feasibility of radical surgery. After a median follow-up of 33.6 months (mo.), median OS was 26.6 mo. (95% CI 23.8–29.4) and median RFS was 10.6 mo. (95% CI 6.3–14.8). Pathologic response according to the Mandard criteria (TRG 1–3, not reached versus 20.5 mo. for TRG 4–5; HR 0.23, p=0.019), PS ECOG ≤ 1 (26.7 mo. for PS ≤ 1 versus 11.2 mo. for PS >1; HR 0.3, p=0.022) and a low metastatic burden (26.7 mo. for single site versus 12.9 mo. for ≥2 sites; HR 0.34, p=0.039) were related to good prognosis. No major intraoperative complications nor surgery-related deaths occurred in our series.DiscussionA sequential strategy of preoperative chemotherapy and radical surgical excision of both primary tumor and metastases was demonstrated to significantly improve OS and RFS. Multidisciplinary evaluation is mandatory to identify patients who could benefit from this strategy.
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- 2024
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228. Gender minorities in breast cancer – Clinical trials enrollment disparities: Focus on male, transgender and gender diverse patients
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Federica Miglietta, Letizia Pontolillo, Carmine De Angelis, Roberta Caputo, Monica Marino, Emilio Bria, Rossana Di Rienzo, Annarita Verrazzo, Carlo Buonerba, Giampaolo Tortora, Giuseppe Di Lorenzo, Lucia Del Mastro, Mario Giuliano, Filippo Montemurro, Fabio Puglisi, Valentina Guarneri, Michelino De Laurentiis, Luca Scafuri, and Grazia Arpino
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Breast cancer ,Gender minorities ,Male ,Transgender and gender diverse people ,Gender diversity ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: The last years have seen unprecedented improvement in breast cancer (BC) survival rates. However, this entirely apply to female BC patients, since gender minorities (male, transgender/gender-diverse) are neglected in BC phase III registration clinical trials. Methods: We conducted a scoping review of phase III clinical trials of agents with a current positioning within the therapeutic algorithms of BC. Results: We selected 51 phase III trials. Men enrollment was allowed in 35.3% of trials. In none of the trial inclusion/exclusion criteria referred to transgender/gender-diverse people. A numerical higher rate of enrolled men was observed in the contemporary as compared to historical group.We found a statistically significant association between the drug class and the possibility of including men: 100%, 80%, 50%, 33.3%, 25%, 10% and 9.1% of trials testing ICI/PARP-i, ADCs, PI3K/AKT/mTOR-i, anti-HER2 therapy, CDK4/6-i, ET alone, and CT alone.Overall, 77409 patients were enrolled, including 112 men (0.2%). None of the trial reported transgender/gender-diverse people proportion. Studies investigating PARP-i were significantly associated with the highest rate of enrolled men (1.42%), while the lowest rates were observed for trials of CT (0.13%), ET alone (0.10%), and CDK 4/6-I (0.08%), p
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- 2024
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229. SWANe: Standardized workflow for advanced neuroimaging in epilepsy
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Maurilio Genovese, Agostino Arcasensa, Silvia Morbelli, Matteo Lenge, Carmen Barba, Laura Mirandola, Maria Eugenia Caligiuri, Massimo Caulo, Ferruccio Panzica, Francesco Cardinale, Camilla Rossi-Espagnet, Domenico Tortora, and Anna Elisabetta Vaudano
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Multimodal imaging ,Focal epilepsy ,Positron emission tomography ,Arterial Spin Labelling ,Computer software ,QA76.75-76.765 - Abstract
Standardized Workflow for Advanced Neuroimaging in Epilepsy (SWANe) software provides researchers with a platform to analyze multimodal imaging modalities and to automatically combine the data from each modality into an integrating three-dimensional fashion. The software comes with a GUI and is designed to be user-friendly and for the not-technical public. SWANe is implemented in Python language and falls within the MIT license. The toolbox builds on a combination of existing methods to improve the user's power to perform analyses on different types of structural, functional, and metabolic imaging. SWANe has been developed in principle for the study of focal epilepsies of any age but it might be prospectively applied in different neurological diseases and for presurgical planning.
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- 2024
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230. Eosinophilic esophagitis in adults and adolescents: epidemiology, diagnostic challenges, and management strategies for a type 2 inflammatory disease
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Edoardo Vincenzo Savarino, Giovanni Barbara, Maria Beatrice Bilò, Nicola De Bortoli, Antonio Di Sabatino, Salvatore Oliva, Roberto Penagini, Francesca Racca, Annalisa Tortora, Filippo Rumi, and Americo Cicchetti
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Eosinophilic esophagitis (EoE) is recognized as a chronic type 2 inflammatory disease characterized by the eosinophilic infiltration of the esophageal tissue, posing a significant disease burden and highlighting the necessity for novel management strategies to address unmet clinical needs. Objectives: To critically evaluate the existing literature on the epidemiology and management of EoE, identify evidence gaps, and assess the efficacy of current and emerging treatment modalities. Design: An extensive literature review was conducted, focusing on the epidemiological trends, diagnostic challenges, and therapeutic interventions for EoE. This was complemented by a survey among physicians and consultations with a scientific expert panel, including a patient’s association (ESEO Italia), to enrich the study findings. Data sources and methods: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, scrutinizing epidemiological studies and management research to compile comprehensive insights into the disease’s landscape. The physician survey and expert panel discussions aimed to bridge identified evidence gaps. Results: The review included 59 epidemiological and 51 management studies, uncovering variable incidence and prevalence rates of EoE globally, with an estimated diagnosed prevalence of 41 per 100,000 in Italy. Diagnostic challenges were identified, including nonspecific symptoms and the lack of definitive biomarkers, which complicate the use of endoscopy. Treatment options such as elimination diets, proton-pump inhibitors, and swallowed corticosteroids were found to have varying success rates, while Dupilumab, an emerging therapy targeting interleukin (IL)-4 and IL-13, shows promise. Conclusion: Despite advancements in understanding and managing EoE, significant unmet clinical needs remain, particularly in biomarker identification, therapy personalization, and cost-effectiveness evaluation. A comprehensive, multidimensional approach to patient management is required, emphasizing the importance of early symptom recognition, accurate diagnosis, and tailored treatment strategies. Dupilumab offers potential as a novel treatment, underscoring the need for future research to explore the economic and social dimensions of EoE care pathways.
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- 2024
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231. Clinical tutoring for nursing students: analysis of the Barletta-Andria-Trani Health Facility experience
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Federico Ruta, Michele Massaro, Beatrice Dibenedetto, Valeria Lombardi, Francesca Biscosi, Elena Barile, Gioacchino Dibenedetto, Giuseppe Papagni, Nicola Tortora, Tatiana Bolgeo, Vincenzo Dicuonzo, Mauro Parozzi, Paolo Ferrara, Terzoni Stefano, and Enkeleda Gjini
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Clinical clerkship ,Clinical environment ,Nursing education ,Nursing student ,Satisfaction ,Nursing ,RT1-120 - Abstract
BACKGROUND: University nursing tutoring from clinical nurses is an essential and necessary component in supporting students to be successful in curricular activities in support of classroom learning. The aim of this study was to describe the experience of the nurse involved in clinical tutoring of students in the Bachelor of Science in Nursing course at an Italian university. METHODS: A survey questionnaire created on the basis of a literature review was sent to all nurses involved in clinical tutoring within the ASL Bt. RESULTS: 67.44% reported that they had never received any kind of specific training despite the fact that 92.51% considered it essential for the correct performance of the role. 82.13% believe that this activity is not adequately valued CONCLUSIONS: The results obtained represent beginning of an educational pathway aimed at standardising the training processes of the clinical tutor, oriented towards improving the learning pathway of the future nursing class.
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- 2024
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232. Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy
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Park, Bo-yong, Larivière, Sara, Rodríguez-Cruces, Raul, Royer, Jessica, Tavakol, Shahin, Wang, Yezhou, Caciagli, Lorenzo, Caligiuri, Maria Eugenia, Gambardella, Antonio, Concha, Luis, Keller, Simon S, Cendes, Fernando, Alvim, Marina KM, Yasuda, Clarissa, Bonilha, Leonardo, Gleichgerrcht, Ezequiel, Focke, Niels K, Kreilkamp, Barbara AK, Domin, Martin, von Podewils, Felix, Langner, Soenke, Rummel, Christian, Rebsamen, Michael, Wiest, Roland, Martin, Pascal, Kotikalapudi, Raviteja, Bender, Benjamin, O’Brien, Terence J, Law, Meng, Sinclair, Benjamin, Vivash, Lucy, Kwan, Patrick, Desmond, Patricia M, Malpas, Charles B, Lui, Elaine, Alhusaini, Saud, Doherty, Colin P, Cavalleri, Gianpiero L, Delanty, Norman, Kälviäinen, Reetta, Jackson, Graeme D, Kowalczyk, Magdalena, Mascalchi, Mario, Semmelroch, Mira, Thomas, Rhys H, Soltanian-Zadeh, Hamid, Davoodi-Bojd, Esmaeil, Zhang, Junsong, Lenge, Matteo, Guerrini, Renzo, Bartolini, Emanuele, Hamandi, Khalid, Foley, Sonya, Weber, Bernd, Depondt, Chantal, Absil, Julie, Carr, Sarah JA, Abela, Eugenio, Richardson, Mark P, Devinsky, Orrin, Severino, Mariasavina, Striano, Pasquale, Parodi, Costanza, Tortora, Domenico, Hatton, Sean N, Vos, Sjoerd B, Duncan, John S, Galovic, Marian, Whelan, Christopher D, Bargalló, Núria, Pariente, Jose, Conde-Blanco, Estefania, Vaudano, Anna Elisabetta, Tondelli, Manuela, Meletti, Stefano, Kong, Xiang‐Zhen, Francks, Clyde, Fisher, Simon E, Caldairou, Benoit, Ryten, Mina, Labate, Angelo, Sisodiya, Sanjay M, Thompson, Paul M, McDonald, Carrie R, Bernasconi, Andrea, Bernasconi, Neda, and Bernhardt, Boris C
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Epilepsy ,Neurodegenerative ,Clinical Research ,Brain Disorders ,Neurosciences ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Atrophy ,Connectome ,Epilepsy ,Temporal Lobe ,Hippocampus ,Humans ,Magnetic Resonance Imaging ,temporal lobe epilepsy ,asymmetry ,cortical thickness ,multi-site ,gradients ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy.
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- 2022
233. The Fornax Cluster VLT Spectroscopic Survey IV -- Cold kinematical substructures in the Fornax core from COSTA
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Napolitano, N. R., Gatto, M., Spiniello, C., Cantiello, M., Hilker, M., Arnaboldi, M., Tortora, C., Chaturvedi, A., D'Abrusco, R., Li, R., Paolillo, M., Peletier, R., Saifollahi, T., Spavone, M., Venhola, A., Pota, V., Capaccioli, M., and Longo, G.
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Astrophysics - Astrophysics of Galaxies - Abstract
The COld STream finder Algorithm (COSTA) is a novel algorithm to find streams in the phase space of planetary nebulae (PNe) and globular cluster (GCs) populations. COSTA isolates groups of particles with small velocity dispersion, using an iterative sigma-clipping over a defined number of neighbor particles. We have applied COSTA to a catalog of about 2000 PNe and GCs from the Fornax Cluster VLT Spectroscopic Survey (FVSS), within 200 kpc from the cluster core, to detect cold substructures and characterize their kinematics. We have found 13 cold substructures, with velocity dispersion ranging from 20 to 100 kms^{-1}, which are likely associated either to large galaxies or to ultra-compact dwarf (UCD) galaxies in the Fornax core. These streams show a clear correlation of their luminosity with the internal velocity dispersion, and their surface brightness with size and distance from the cluster center that are compatible with dissipative processes producing them. However, we cannot exclude that some of these substructures have formed by violent relaxation of massive satellites finally merged into the central galaxy. Among these substructures we have: a stream connecting NGC1387 to the central galaxy, NGC1399, previously reported in literature; a new giant stream produced by the interaction of NGC1382 with NGC1380 and possibly NGC1381; a series of streams kinematically connected to nearby ultra compact dwarf galaxies; clumps of tracers with no clear kinematical association to close cluster members. We show evidence for a variety of cold substructure predicted in simulations. Most of the streams are kinematically connected to UCDs, supporting the scenario that they can be remnants of disrupted dwarf systems. [abridged], Comment: 27 Pages, 15 Figures. Accepted for publication in Astronomy and Astrophysics
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- 2021
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234. STEP Survey II: Structural Analysis of 170 star clusters in the SMC
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Gatto, M., Ripepi, V., Bellazzini, M., Tosi, M., Cignoni, M., Tortora, C., Leccia, S., Clementini, G., Grebel, E. K., Longo, G., Marconi, M., and Musella, I.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We derived surface brightness profiles in the \emph{g} band for 170 Small Magellanic Cloud (SMC) star clusters (SCs) mainly located in the central region of the galaxy. We provide a set of homogeneous structural parameters obtained by fitting Elson, Fall \& Freeman (EFF) and King models. Through a careful analysis of their colour-magnitude diagrams (CMDs) we also supply the ages for a subsample of 134 SCs. For the first time, such a large sample of SCs in the SMC is homogeneously characterized in terms of their sizes, luminosities and masses, widening the probed region of the parameter space, down to hundreds of solar masses. We used these data to explore the evolution of the SC's structural parameters with time. In particular, we confirm the existence of a physical mechanism that induces an increase of the core radius after 0.3-1.0 Gyr. We suggest that cluster mass could be the main parameter driving the inner expansion, as none of the SCs having $\log (M/M_{\odot}) \leq 3.5$~dex analysed in this work undergoes to such an expansion. We also detected a mass-size relationship almost over the entire range of SCs masses investigated here. Finally, our data suggest that globally the SMC SC system is dynamically evolved., Comment: 24 pages, 14 figures. Accepted for publication by MNRAS
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- 2021
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235. YMCA-1: a new remote star cluster of the Milky Way?
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Gatto, M., Ripepi, V., Bellazzini, M., Tosi, M., Tortora, C., Cignoni, M., Spavone, M., Dall'ora, M., Clementini, G., Cusano, F., Longo, G., Musella, I., Marconi, M., and Schipani, P.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report the possible discovery of a new stellar system (YMCA-1), identified during a search for small scale overdensities in the photometric data of the YMCA survey. The object's projected position lies on the periphery of the Large Magellanic Cloud about $13^\circ$ apart from its center. The most likely interpretation of its color-magnitude diagram, as well as of its integrated properties, is that YMCA-1 may be an old and remote star cluster of the Milky Way at a distance of 100 kpc from the Galactic center. If this scenario could be confirmed, then the cluster would be significantly fainter and more compact than most of the known star clusters residing in the extreme outskirts of the Galactic halo, but quite similar to Laevens~3. However, much deeper photometry is needed to firmly establish the actual nature of the cluster and the distance to the system., Comment: 5 Pages, 3 figures. Published on Research Notes of the AAS
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- 2021
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236. Morphogenesis and self-organization of persistent filaments confined within flexible biopolymeric shells
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Tortora, Maxime M. C. and Jost, Daniel
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Statistical Mechanics ,Physics - Computational Physics - Abstract
We systematically explore the self-assembly of semi-flexible polymers in deformable spherical confinement across a wide regime of chain stiffness, contour lengths and packing fractions by means of coarse-grained molecular dynamics simulations. Compliant, DNA-like filaments are found to undergo a continuous crossover from two distinct surface-ordered quadrupolar states, both characterized by tetrahedral patterns of topological defects, to either longitudinal or latitudinal bipolar structures with increasing polymer concentrations. These transitions, along with the intermediary arrangements that they involve, may be attributed to the combination of an orientational wetting phenomenon with subtle density- and contour-length-dependent variations in the elastic anisotropies of the corresponding liquid crystal phases. Conversely, the organization of rigid, microtubule-like polymers evidences a progressive breakdown of continuum elasticity theory as chain dimensions become comparable to the equilibrium radius of the encapsulating membrane. In this case, we observe a gradual shift from prolate, tactoid-like morphologies to oblate, erythrocyte-like structures with increasing contour lengths, which is shown to arise from the interplay between nematic ordering, polymer and membrane buckling. We further provide numerical evidence of a number of yet-unidentified, self-organized states in such confined systems of stiff achiral filaments, including spontaneous spiral smectic assemblies, faceted polyhedral and twisted bundle-like arrangements. Our results are quantified through the introduction of several order parameters and an unsupervised learning scheme for the localization of surface topological defects, and are in excellent agreement with field-theoretical predictions as well as classical elastic theories of thin rods and spherical shells.
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- 2021
237. TSEN54 Gene-Related Pontocerebellar-Hypoplasia and Role of Prenatal MR Imaging: Besides the Common Posterior Fossa Cystic Malformations
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Tortora, Mario, Spaccini, Luigina, Lanna, Mariano, Zambon, Marta, Izzo, Giana, Parazzini, Cecilia, and Righini, Andrea
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- 2023
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238. An overview of torus fully homomorphic encryption
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Maria Ferrara, Antonio Tortora, and Maria Tota
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tfhe ,fully homomorphic encryption ,bootstrapping ,learning with errors ,Mathematics ,QA1-939 - Abstract
The homomorphic encryption allows us to operate on encrypted data, making any action less vulnerable to hacking. The implementation of a fully homomorphic cryptosystem has long been impracticable. A breakthrough was achieved only in 2009 thanks to Gentry [C. Gentry, Fully homomorphic encryption using ideal lattices, STOC '09: Proceedings of the forty-first annual ACM symposium on Theory of computing, Association for Computing Machinery, New York, (2009) 169--178.] with his innovative idea of bootstrapping. TFHE is a torus-based fully homomorphic cryptosystem using the bootstrapping technique. This paper aims to present TFHE from an algebraic point of view.
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- 2023
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239. Talniflumate abrogates mucin immune suppressive barrier improving efficacy of gemcitabine and nab-paclitaxel treatment in pancreatic cancer
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Antonio Agostini, Ilaria Guerriero, Geny Piro, Giuseppe Quero, Luca Roberto, Annachiara Esposito, Alessia Caggiano, Lorenzo Priori, Giulia Scaglione, Francesco De Sanctis, Antonella Sistigu, Martina Musella, Alberto Larghi, Gianenrico Rizzatti, Donatella Lucchetti, Sergio Alfieri, Alessandro Sgambato, Emilio Bria, Laura Bizzozero, Sabrina Arena, Stefano Ugel, Vincenzo Corbo, Giampaolo Tortora, and Carmine Carbone
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Intraductal mucinous neoplasms (IPMNs) ,Spatial transcriptomics ,Pancreatic ductal adenocarcinoma (PDAC) ,Organoid interaction platform ,Syngeneic mouse models ,Medicine - Abstract
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. This is due to its aggressive course, late diagnosis and its intrinsic drugs resistance. The complexity of the tumor, in terms of cell components and heterogeneity, has led to the approval of few therapies with limited efficacy. The study of the early stages of carcinogenesis provides the opportunity for the identification of actionable pathways that underpin therapeutic resistance. Methods We analyzed 43 Intraductal papillary mucinous neoplasms (IPMN) (12 Low-grade and 31 High-grade) by Spatial Transcriptomics. Mouse and human pancreatic cancer organoids and T cells interaction platforms were established to test the role of mucins expression on T cells activity. Syngeneic mouse model of PDAC was used to explore the impact of mucins downregulation on standard therapy efficacy. Results Spatial transcriptomics showed that mucin O-glycosylation pathway is increased in the progression from low-grade to high-grade IPMN. We identified GCNT3, a master regulator of mucins expression, as an actionable target of this pathway by talniflumate. We showed that talniflumate impaired mucins expression increasing T cell activation and recognition using both mouse and human organoid interaction platforms. In vivo experiments showed that talniflumate was able to increase the efficacy of the chemotherapy by boosting immune infiltration. Conclusions Finally, we demonstrated that combination of talniflumate, an anti-inflammatory drug, with chemotherapy effectively improves anti-tumor effect in PDAC.
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- 2023
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240. Refactoring and performance analysis of the main CNN architectures: using false negative rate minimization to solve the clinical images melanoma detection problem
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Luigi Di Biasi, Fabiola De Marco, Alessia Auriemma Citarella, Modesto Castrillón-Santana, Paola Barra, and Genoveffa Tortora
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Melanoma ,Skin cancer ,Deep leaning ,IoMT ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Melanoma is one of the deadliest tumors in the world. Early detection is critical for first-line therapy in this tumor pathology and it remains challenging due to the need for histological analysis to ensure correctness in diagnosis. Therefore, multiple computer-aided diagnosis (CAD) systems working on melanoma images were proposed to mitigate the need of a biopsy. However, although the high global accuracy is declared in literature results, the CAD systems for the health fields must focus on the lowest false negative rate (FNR) possible to qualify as a diagnosis support system. The final goal must be to avoid classification type 2 errors to prevent life-threatening situations. Another goal could be to create an easy-to-use system for both physicians and patients. Results To achieve the minimization of type 2 error, we performed a wide exploratory analysis of the principal convolutional neural network (CNN) architectures published for the multiple image classification problem; we adapted these networks to the melanoma clinical image binary classification problem (MCIBCP). We collected and analyzed performance data to identify the best CNN architecture, in terms of FNR, usable for solving the MCIBCP problem. Then, to provide a starting point for an easy-to-use CAD system, we used a clinical image dataset (MED-NODE) because clinical images are easier to access: they can be taken by a smartphone or other hand-size devices. Despite the lower resolution than dermoscopic images, the results in the literature would suggest that it would be possible to achieve high classification performance by using clinical images. In this work, we used MED-NODE, which consists of 170 clinical images (70 images of melanoma and 100 images of naevi). We optimized the following CNNs for the MCIBCP problem: Alexnet, DenseNet, GoogleNet Inception V3, GoogleNet, MobileNet, ShuffleNet, SqueezeNet, and VGG16. Conclusions The results suggest that a CNN built on the VGG or AlexNet structure can ensure the lowest FNR (0.07) and (0.13), respectively. In both cases, discrete global performance is ensured: 73% (accuracy), 82% (sensitivity) and 59% (specificity) for VGG; 89% (accuracy), 87% (sensitivity) and 90% (specificity) for AlexNet.
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- 2023
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241. Unexpected finding of a rare pathogenic germline BRCA1 variant in an intrahepatic cholangiocarcinoma using the Oncomine Focus DNA assay: clinical and diagnostic implications
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De Bonis, Maria, Mannavola, Francesco, Salvatore, Lisa, De Paolis, Elisa, Nero, Camilla, Giacò, Luciano, Tortora, Giampaolo, Giuliante, Felice, Urbani, Andrea, Scambia, Giovanni, Normanno, Nicola, and Minucci, Angelo
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- 2023
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242. Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach
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Botticelli, Andrea, Cirillo, Alessio, Pomati, Giulia, Cortesi, Enrico, Rossi, Ernesto, Schinzari, Giovanni, Tortora, Giampaolo, Tomao, Silverio, Fiscon, Giulia, Farina, Lorenzo, Scagnoli, Simone, Pisegna, Simona, Ciurluini, Fabio, Chiavassa, Antonella, Amirhassankhani, Sasan, Ceccarelli, Fulvia, Conti, Fabrizio, Di Filippo, Alessandra, Zizzari, Ilaria Grazia, Napoletano, Chiara, Rughetti, Aurelia, Nuti, Marianna, Mezi, Silvia, and Marchetti, Paolo
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- 2023
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243. Morphological and chemical changes in nuclear graphite target under vacuum and high-temperature conditions
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De Rosa, Stefania, Colantoni, Elisabetta, Branchini, Paolo, Orestano, Domizia, Passeri, Antonio, Bussetti, Gianlorenzo, Centofante, Lisa, Corradetti, Stefano, Marsotto, Martina, Battocchio, Chiara, Riccucci, Cristina, and Tortora, Luca
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- 2024
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244. Marfan and Loeys-Dietz aortic phenotype: A potential tool for diagnosis and management
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Lovato, Luigi, Cefarelli, Mariano, Di Marco, Luca, Arcioni, Daniel, Tortora, Giada, Dormi, Ada, Schicchi, Nicolò, Mariucci, Elisabetta, Di Eusanio, Marco, Pacini, Davide, and Fattori, Rossella
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- 2024
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245. The interaction of patients’ physical status and time to endoscopy on mortality risk in patients with upper gastrointestinal bleeding: A national prospective cohort study
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Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Balzano, A, Bazzoli, F, Bennato, R, Bianco, M A, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De Fanis, C, De Filippo, FR, de Franchis, R, Dell‘Era, A, De Nigris, F, De Matthaeis, M, Di Giorgio, P, Di Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana’, B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R, Metrangolo, S, Montalbano, L M, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Bucci, Cristina, Marmo, Clelia, Soncini, Marco, Riccioni, Maria Elena, Laursen, Stig B., Gralnek, Ian M., and Marmo, Riccardo
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- 2024
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246. Identification and management of gastrointestinal manifestations of hereditary transthyretin amyloidosis: Recommendations from an Italian group of experts
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Cappello, Maria, Barbara, Giovanni, Bellini, Massimo, Consalvo, Danilo, Di Sabatino, Antonio, Marasco, Giovanni, Principi, Mariabeatrice, Savarino, Edoardo Vincenzo, Tortora, Annalisa, and Obici, Laura
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- 2024
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247. Gender minorities in breast cancer – Clinical trials enrollment disparities: Focus on male, transgender and gender diverse patients
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Miglietta, Federica, Pontolillo, Letizia, De Angelis, Carmine, Caputo, Roberta, Marino, Monica, Bria, Emilio, Di Rienzo, Rossana, Verrazzo, Annarita, Buonerba, Carlo, Tortora, Giampaolo, Di Lorenzo, Giuseppe, Del Mastro, Lucia, Giuliano, Mario, Montemurro, Filippo, Puglisi, Fabio, Guarneri, Valentina, De Laurentiis, Michelino, Scafuri, Luca, and Arpino, Grazia
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- 2024
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248. Congenital Cytomegalovirus Infection With Isolated “Minor” Lesions at Fetal Magnetic Resonance Imaging: Long-Term Neurological Outcome
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Doneda, Chiara, Scelsa, Barbara, Introvini, Paola, Zavattoni, Maurizio, Orcesi, Simona, Lombardi, Giuseppina, Pugni, Lorenza, Fumagalli, Monica, Rustico, Mariangela, Vola, Elena, Arrigoni, Filippo, Fabbri, Elisa, Tortora, Mario, Izzo, Giana, Genovese, Maurilio, Parazzini, Cecilia, Tassis, Beatrice, Ronchi, Andrea, Pietrasanta, Carlo, Triulzi, Fabio, and Righini, Andrea
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- 2024
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249. Role of nutritional therapy on dietary habits and glycemic control in insulin-treated kidney transplant patients with diabetes
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Clemente, G., Della Pia, N., Bramanti, A., Cerbara, L., Russo, G., De Rosa, P., Marotta, V., Tortora, A., Riccio, M., and Vitale, M.
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- 2024
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250. Negative MRI and a seizure onset zone close to eloquent areas in FCD type II: Application of MRg-LiTT after a SEEG re-evaluation in pediatric patients with a previous failed surgery
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Chiarello, D., Cognolato, E., Francione, S., Nobile, G., Bosisio, L., Barbagallo, G., Pacetti, M., Tortora, D., Cantalupo, G., Nobili, L., and Consales, A.
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- 2024
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