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We propose a novel strategy for the construction of a Z-scheme photocatalyst based on in situ chemical modification and autogenous black phosphorus nanosheets.

Abstract: Harmful microorganisms are widely present in the surrounding environment, causing a large number of infectious diseases in human society and serious negative effects on human life. In order to resist the damage of harmful microorganisms, antimicrobial agents that inhibit the growth of microorganisms came into being. This review aimed to encompass current syntheses and applications of N-halamines antimicrobial agents in the past five years, highlighting recent significant breakthroughs. This review included an introduction to the classification of antimicrobial agents, antimicrobial mechanisms, syntheses, and applications of small molecular N-halamines and N-halamines polymers. And finally, the conclusion and outlooks of N-halamines antimicrobial agents were provided.

No study has evaluated the impact of regimen on recurrence, metastasis and survival in patients with adenoid cystic carcinoma (ACC). The present study aimed to compare the efficacy of radioactive seed implantation and other regimens in treating ACC, so as to investigate the clinical applicability of radioactive seed implantation and determine the indications for this regimen.A total of 188 patients with ACC in oromaxillofacial region were allocated to four groups according to the treatment regimen: group 1 was treated with a combination of surgery andThe overall survival rates of 188 patients and groups 1, 2, 3 and 4 were 85.7%, 75%, 68.2% and 37.5%, respectively. Cox regression analysis revealed that age, T stage, N stage and regimen were independent prognostic factors of survival. Amongst patients with primary ACC, the efficacy of radioactive seed implantation was higher in those with perineural invasion than in those without.Patient age, T stage, N stage and regimen are independent prognostic factors of survival in patients with ACC. Patients treated with surgery combined with postoperative

Many high-performance fluid dynamic models do not consider fluids in a rotating environment and often require a significant amount of computational time. The current study proposes a novel parameter-based field reconstruction convolutional neural network (PFR-CNN) approach to model the solute concentration field in rotationally influenced fluids. A new three-dimensional (3D) numerical solver, TwoLiquidMixingCoriolisFoam, was implemented within the framework of OpenFOAM to simulate effluents subjected to the influence of rotation. Subsequently, the developed numerical solver was employed to conduct numerical experiments to generate numerical data. A PFR-CNN was designed to predict the concentration fields of neutrally buoyant effluents in rotating water bodies based on the Froude number (Fr) and Rossby number (Ro). The proposed PFR-CNN was trained and validated with a train-validation dataset. The predicted concentration fields for two additional tests demonstrated the good performance of the proposed approach, and the algorithm performed better than traditional approaches. This study offers a new 3D numerical solver, and a novel PFR-CNN approach can predict solute transport subjected to the effects of rotation in few seconds, and the PFR-CNN can significantly reduce the computational costs. The study can significantly advance the ability to model flow and solute transport processes, and the proposed CNN-based approach can potentially be employed to predict the spatial distribution of any physical variable in the lentic, ocean, and earth system.

The petrogenesis of late Ordovician–early Silurian adakitic plutons in the North Qilian suture zone (NQSZ) and their copper mineralization potential remain poorly understood. Here we present a detailed study of the Heishishan (HSS) granodiorite–granite pluton, spatially associated with Cu–Au mineralization in the eastern section of the NQSZ. Zircon U–Pb dating confirms that the granodiorite–granite were formed at ca. 438–435 Ma, in association with a continental collision. Geochemically, the granitoids resemble low-Mg adakitic rocks featured by elevated Sr/Y and (La/Yb)N ratios with depleted MgO, Cr, and Ni concentrations, suggesting minimal mantle contribution. They are sodium rich with K2O/Na2O < 1, and have higher and more varied Sr/Y, but lower La/Yb than those from the continental lower crust. The εHf(t) values of zircon grains are positive and vary in a wide range of +2.0–12.7, indicating a heterogeneous source rather than a single arc basaltic source. They show moderately radiogenic Sr and Nd isotope compositions with initial 87Sr/86Sr ratios of 0.705101–0.706312 and εNd(t) values of +0.5–1.0, most likely a mixed source of the oceanic basaltic crust plus ca. 15–20% overlying sediments. The magmatic oxygen fugacity was relatively low as indicated by zircon Ce(IV)/Ce(III) ratios of 32–156, which is unfavorable for a large copper mineralization.

Familial adenomatous polyposis (FAP) is an autosomal dominant disease caused by pathogenic germline adenomatous polyposis coli mutation, and characterized with multiple adenomas in the colon and the rectum. Various genetic variants have been confirmed to be associated with corresponding FAP phenotypes, which play important roles in the diagnosis and surgical treatment of FAP. Generally, proctocolectomy is recommended for FAP patients at the age of 20s. Exceptionally, for patients with attenuated FAP, high-risk of desmoid, chemoprevention therapy, or other circumstances, surgery can be postponed. With the wide application of minimal invasive surgery in colorectal cancer, laparoscopic, robotic surgery, and natural orifice specimen extraction are proved to be feasible for FAP patients, but high-level evidences are needed to confirm their safety and advantages. In the times of precise medicine, the surgical management of FAP should vary with individuals based on genotype, phenotype, and clinical practice. Therefore, in addition to innovation in surgical procedures, investigation in links between genetic features and phenotypes will be helpful to optimize the surgical management of FAP in the future.

Background Rho-associated protein kinase(ROCK) plays important roles in cell proliferation and migration, depending on cancer types. ROCK inhibitor Y-27632 was referred as a potential immunotherapy strategy for cancer treatment. Oral squamous cell carcinoma (OSCC) remains one of the most aggressive oral carcinoma types. Y-27632 was shown to block the growth, migration and invasion of Cal27 cells, but no detailed studies of underlying mechanisms have been reported. Methods In this study we explored the effect of Y27632 on OSCC (Cal27, SCC4, SCC9) by comparing with and without Y27632 treatment in vitro and in vivo. And further investigations were done to reveal the expression of AKT/mTOR pathway by Biochemical assays, additionally AKT activator (SC79) or mTOR activator (3BDO) was utilized to evaluate the roles of AKT/mTOR pathway in Y27632-induced tumor suppression. Results Our data showed Y-27632 had a strong inhibitory activity against OSCC (Cal27, SCC4, SCC9). In vivo assays confirmed that Y-27632 suppressed OSCC growth by reducing cell proliferation, and importantly Y-27632 did not have any evident toxicity on normal tissues. Biochemical assays demonstrated that Y-27632 inactivated the AKT/mTOR pathway, and treatment with SC79 or 3BDO, respectively AKT and mTOR activator rescued the cell growth and migration inhibition elicited by Y-27632. Further investigations revealed that Y-27632 could enhance cell autophagy by suppressing AKT/mTOR pathway. Conclusions Our study demonstrated that Y-27632 significantly suppressed the AKT/mTOR pathway to promote cell autophagy to inhibit OSCC growth, providing a potential therapeutic drug for OSCC treatment in the future.

TRAAK and TREK2 are two-pore domain K(+) (K2P) channels and modulated by diverse factors including temperature, membrane stretching, and lipids, such as phosphatidic acid. In addition, copper and zinc, both of which are essential for life, are known to regulate TREK2 and a number of other ion channels. However, the role of ions in the association of lipids with integral membrane proteins is poorly understood. Here, we discover cupric ions selectively modulate the binding of phosphatidylserine (PS) to TRAAK but not TREK2. Other divalent cations (Ca(2+), Mg(2+), and Zn(2+)) bind both channels but have no impact on binding PS and other lipids. Additionally, TRAAK binds more avidly to Cu(2+) and Zn(2+) than TREK2. In the presence of Cu(2+), TRAAK binds similarly to PS with different acyl chains, indicating a crucial role of the serine headgroup in coordinating Cu(2+). High-resolution native mass spectrometry (MS) enables the determination of equilibrium binding constants for distinct Cu(2+)-bound stoichiometries and uncovered the highest coupling factor corresponds to a 1:1 PS-to-Cu(2+) ratio. Interestingly, the next three highest coupling factors had a ~1.5:1 PS-to-Cu(2+) ratio. Our findings bring forth the role of cupric ions as an essential cofactor in selective TRAAK-PS interactions.

The unprecedented rate of metro construction has led to a highly complex network of metro lines. Tunnels are being overlapped to an ever-increasing degree. This paper investigates the deformation response of double-track overlapped tunnels in Tianjin, China using finite element analysis (FEA) and field monitoring, considering the attributes of different tunneling forms. With respect to the upper tunneling, the results of the FEA and field monitoring showed that the maximum vertical displacements of the ground surface during the tail passage were 2.06 mm, 2.25 mm and 2.39 mm obtained by the FEA, field monitoring and Peck calculation, respectively; the heaves on the vertical displacement curve were observed at 8 m (1.25D, where D is the diameter of the tunnel) away from the center of the tunnel and the curve at both sides was asymmetrical. Furthermore, the crown and bottom produce approximately 0.38 mm and 1.26 mm of contraction, respectively. The results of the FEA of the upper and lower sections demonstrated that the tunneling form has an obvious influence on the deformation response of the double-track overlapped tunnel. Compared with the upper tunneling, the lower tunneling exerted significantly less influence on the deformation response, which manifested as a smaller displacement of the strata and deformation of the existing tunnel. The results of this study on overlapped tunnels can provide a reference for similar projects in the future.

Drawing from the theory of territorial behavior, this article predicts the explanatory role of silence behavior in the relationship between knowledge hiding and hider's innovative behavior in Chinese organizations, and the potential of Zhongyong thinking in mitigating the detrimental effect of knowledge hiding. Results derived from a time-lagged and multi-source survey support our hypotheses. Specifically, knowledge hiding is negatively associated with the innovative behavior of the hider. Silence behavior mediates the relationship between knowledge hiding and innovative behavior. Meanwhile, Zhongyong thinking moderates the positive relationship between knowledge hiding and silence behavior, as well as the indirect relationship between knowledge hiding and innovative behavior through silence behavior. Theoretical and practical implications are discussed based on these findings.

It is found through centrifuge model tests that the cyclic lateral load on a pile reduces the shaft friction and induces additional pile settlement. A theoretical model using the load-transfer method was proposed for the settlement prediction of cyclic laterally loaded piles in dry sand. A simple formula was established to quickly predict the pile settlement in practical engineering. The theoretical model provided a reasonable estimate of the pile settlement, while the predictions from the proposed quick prediction formula were relatively conservative. A new concept of ‘settlement-controlled design’ was proposed to advance the methodology for the design of a pile by considering potential settlement after many cycles of lateral loads. According to the design plane derived from this study, it was suggested that the design-state points should be limited to the convergent zone.

The past few years have witnessed a surge of interest towards deep reinforcement learning (DRL) in computer networks. With extraordinary ability of feature extraction, DRL has the potential to re-engineer the fundamental resource allocation problems in networking without relying on pre-programmed models or assumptions about dynamic environments. However, such black-box systems suffer from poor robustness, showing high performance variance and poor tail performance. In this work, we propose a unified Teacher-Student learning framework that harnesses rich domain knowledge to improve robustness. The domain-specific algorithms, less performant but more trustable than DRL, play the role of teachers providing advice at critical states; the student neural network is steered to maximize the expected reward as usual and mimic the teacher’s advice meanwhile. The Teacher-Student method comprises of three modules where the confidence check module locates wrong decisions and risky decisions, the reward shaping module designs a new updating function to stimulate the learning of student network, and the prioritized experience replay module to effectively utilize the advised actions. We further implement our Teacher-Student framework in existing video streaming (Pensieve), load balancing (DeepLB), and TCP congestion control (Aurora). Experimental results manifest that the proposed approach reduces the performance standard deviation of DeepLB by 37%; it improves the 90th, 95th, and 99th tail performance of Pensieve by 7.6%, 8.8%, and 10.7% respectively; and it accelerates the growth rate of Aurora by 2x at the initial stage, and achieves a more stable performance in dynamic environments.

This work demonstrates alternative green ammonia processing using nitrogen and water based non-thermal plasma without pure hydrogen supply which results in an enormous amount of CO2 emission.

Hydroxyapatite nanoparticles were tunably synthesized via the use of an aliphatic–ethanol–water three-phase mixture system using micelles as soft templates via an emulsion–hydrothermal synergistic method.

The blind modulation recognition (BMR) of high-order modulation types is a pressing task and needs to be raised in the calendar for the Beyond 5G (B5G) OSTBC-OFDM (Orthogonal Space-Time Block Coded-Orthogonal Frequency Division Multiplexing) system. In this letter, a BMR algorithm based on a project constellation vector which employs a temporal convolutional network (PCV-TCNet) is proposed to recognize 13 modulation formats, such as high-order 1024QAM and 2048QAM. Without any prior information, a zero-forcing blind equalization algorithm is leveraged to reconstruct the impaired signal. Furthermore, the learning content of PCV-TCNet is PCV features, which are transformed by the constellation diagram of the reconstructed signal. In addition, PCV-TCNet utilizes causal and dilated convolutions to accelerate the BMR process. The simulation results verify the proposed PCV-TCNet for recognizing the high-order modulation types in the B5G OSTBC-OFDM system and demonstrate its preferable recognition performance with the lowest complexity to existing methods.

Inspired by the experimental realization of lattice-porous graphene and mesoporous MXenes, the possibility of lattice-penetrated porous titanium nitride, Ti12N8, was proposed and verified by density functional theory calculations.

K9 optical glass is one of the typical components in optical systems. However, because of its poor fracture resistance, it is difficult to polish it with ultra-precision and high-efficiency and without any surface damage simultaneously. The emergence of the obliquely axial ultrasonic vibration-assisted polishing (UVAP) method can solve this problem which encounters in polishing efficiency and shape accuracy. However, due to the unclear material removal profile (MRP) mechanism, obliquely axial UVAP is not widely used in the processing field. This paper introduces the obliquely axial UVAP method in research processes, mainly focusing on the fixed point MRP analysis of the obliquely axial UVAP. Based on Hertz's contact theory, polishing pressure, the length of the semi-long axis (LLA) and the length of the semi-short axis (LSA) of the contact area are calculated under ultrasonic vibration conditions. Meanwhile, the relative linear velocity distribution of the oblique polishing tool in the instantaneous contact area is modeled by mathematical geometry method. A novel model of the MRP distribution for obliquely axial UVAP is proposed following the Preston equation. Subsequently, a series of polishing experiments were carried out to verify this model. The results show that the numerical model has good agreement with the experimental results on MRP, LLA, LSA, material removal depth and material removal rate (MRR). In addition, the material removal capability can be significantly improved by larger ultrasonic amplitude and larger oblique angle. This model not only more clearly elucidates the processing mechanism of obliquely axial UVAP, but also provides theoretical support for the polishing of free-form optical lenses.

Brittle materials such as glass and ceramics have fragile physical properties that result in poor stability in the machining process. Ultrasonic vibration-assisted polishing (UVAP) can improve the surface quality and machining efficiency of the workpiece, which is beneficial to solve the machining problems of brittle materials. In this paper, a theoretical model is established to predict the material removal rate (MRR), surface roughness, maximum contact radius, and maximum material removal depth of BK7 optical glass for different machining parameters. The new model mainly considers the following aspects: (1) Considering the randomness of the shape, the abrasive particle is modeled as a truncated polyhedron. (2) Due to the randomness of distribution, the abrasive particles are considered to be randomly distributed in the contact area between the polishing tool and the workpiece. (3) Based on the Preston equation, a material removal model is established which considers the micro-contact state of the abrasive particles with the workpiece. Compared with the experimental results of BK7 optical glass, the new model has high accuracy in predicting machining performance. It is meaningful to understand the mechanism of UVAP and improve the machining efficiency.