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Background: Bladder cancer stands as the predominant malignant tumor in the urological system, presenting a significant challenge to public health and garnering extensive attention. Recently, with the deepening research into tumor molecular mechanisms, non-coding RNAs (ncRNAs) have emerged as potential biomarkers offering guidance for the diagnosis and prognosis of bladder cancer. However, the definitive role of ncRNAs in bladder cancer remains unclear. Hence, this study aims to elucidate the relevance and significance of ncRNAs through a Meta-analysis. Methods: A systematic meta-analysis was executed, including studies evaluating the diagnostic performance of ncRNAs and their associations with overall survival (OS) and disease-free survival (DFS). Key metrics such as hazard ratios, sensitivity, specificity, and diagnostic odds ratios were extracted and pooled from these studies. Potential publication bias was assessed using Deeks’ funnel plot, and the robustness of the results was ascertained through a sensitivity analysis. Results: Elevated ncRNA expression showed a positive correlation with improved OS, evidenced by a hazard ratio (HR) of 0.82 (95% CI: 0.66-0.96, P<0.001). Similarly, a significant association was observed between heightened ncRNA expression and DFS, with an HR of 0.86 (95% CI: 0.73-0.99, P<0.001). Diagnostic performance analysis across 17 articles yielded a pooled sensitivity of 0.76 and a specificity of 0.83. The diagnostic odds ratio was recorded at 2.71, with the area under the ROC curve (AUC) standing at 0.85. Conclusion: Exosome ncRNAs appear to possess potential significance in the diagnostic and prognostic discussions of bladder cancer. Their relationship with survival outcomes and diagnostic measures suggests a possible clinical utility. Comprehensive investigations are needed to fully determine their role in the ever-evolving landscape of bladder cancer management, especially within the framework of personalized medicine. [ABSTRACT FROM AUTHOR]

A thorough insight into the initiation, segmentation, propagation and interaction of multitrend basin-bounding faults is crucial to restoring the growth history of the faults and clarifying the fault growth pattern and its influence on the structures developed along the margin due to the growth of the basinbounding faults, but systematic studies on the individual influence of the evolution of each fault segment on the present structure are lacking. Based on 3D seismic data, the timing and growth of multitrend basin-bounding faults were analysed using T-z plots and throw backstripping, allowing us to determine the individual effects that each fault segment evolution exerteds on the present-day configuration of the northern margin of the Nanpu Sag. The basinbounding fault is composed of the Xinanzhuang and Baigezhuang faults, and the Xinanzhuang fault comprises three linked segments with varying orientations (i.e., NE-SW, E-W, and NNE-SSW). In comparison, the Baigezhuang fault comprises only two linked NW-SE-oriented fault segments. The evolution process can be divided into three stages. (1) During the early synrift I stage, namely, the isolated fault stage, five isolated multitrend basin-bounding segments were active. (2) During the late synrift I stage, namely, the hard-linkage stage, the five segments propagated laterally and linked with each other, behaving as a single fault. Meanwhile, the NE-trending No. 5 Fault bifurcated upward from the basin-bounding fault to accommodate local stress, and the NW-trending Gaobei Fault deviated from the basin-bounding fault controlled by local stresses induced by differential activities of the multitrend fault segments under the same far-field stress. (3) During the synrift II to postrift linkage development stage, the extension orientation changed from NW-SE- to N-S, and additional displacement accumulated along the basin-bounding fault without further lateral propagation. Newly formed E-W- trending faults developed orthogonal to the extension orientation and linked with preexisting NE- or NW- trending faults, forming a complex fault zone. In addition, influenced by the geometry of the basin-bounding fault, the Laoyemiao Anticline formed by gravitational collapse under the dual action of a rollover anticline and transverse anticline. Furthermore, the evolution of the basin-bounding faults played an important role in controlling the source-to-sink system, and the transition zone was the main provenance channel formed by the segmented growth of the faults. This study provides new insight into multitrend large fault evolution, and their impact on basin development provides a comprehensive explanation of the later structures developed in polyphase rifts. [ABSTRACT FROM AUTHOR]