Search

Your search keyword '"Thombs, Brett D."' showing total 1,846 results
Start Over Author "Thombs, Brett D."
1,846 results on '"Thombs, Brett D."'

202. Interventions to Address Potentially Inappropriate Prescriptions and Over-The-Counter Medication Use Among Adults 65 Years and Older in Primary Care Settings: Protocol for a Systematic Review

Author

Beck, Andrew, primary, Persaud, Navindra, additional, Tessier, Laure A., additional, Grad, Roland, additional, Kidd, Michael R., additional, Klarenbach, Scott, additional, Korownyk, Christina, additional, Moore*, Ainsley, additional, Thombs, Brett D., additional, Mangin, Dee, additional, McCracken, Rita K., additional, McDonald, Emily G., additional, Sirois, Caroline, additional, Kanji, Salmaan, additional, Molnar, Frank, additional, Nicholls, Stuart G., additional, Thavorn, Kednapa, additional, Bennett, Alexandria, additional, Shaver, Nicole, additional, Skidmore, Becky, additional, Mitchelmore, Bradley R., additional, Avey, Marc, additional, Rolland-Harris, Elizabeth, additional, Little*, Julian, additional, and Moher*, David, additional

Published
2021
Full Text
View/download PDF

203. Pain levels and associated factors in the Scleroderma Patient-centered Intervention Network (SPIN) cohort: a multicentre cross-sectional study

Author

Lee, Yvonne C, primary, Fox, Rina S, additional, Kwakkenbos, Linda, additional, Levis, Brooke, additional, Carrier, Marie-Eve, additional, Welling, Joep, additional, Sauvé, Maureen, additional, Mouthon, Luc, additional, Benedetti, Andrea, additional, Bartlett, Susan J, additional, Varga, John, additional, Thombs, Brett D, additional, Henry, Richard S., additional, Gottesman, Karen, additional, Hudson, Marie, additional, Hummers, Laura K., additional, Malcarne, Vanessa L., additional, Mayes, Maureen D., additional, Nielson, Warren R., additional, Riggs, Robert, additional, Assassi, Shervin, additional, El-Baalbaki, Ghassan, additional, Ells, Carolyn, additional, Fligelstone, Kim, additional, Fortuné, Catherine, additional, Frech, Tracy, additional, Gietzen, Amy, additional, Guillot, Geneviève, additional, Harel, Daphna, additional, Hinchcliff, Monique, additional, Johnson, Sindhu R., additional, Larche, Maggie, additional, Leite, Catarina, additional, Nguyen, Christelle, additional, Nielsen, Karen, additional, Pope, Janet, additional, Rannou, François, additional, Richard, Michelle, additional, Rodriguez-Reyna, Tatiana Sofia, additional, Schouffoer, Anne A., additional, Suarez-Almazor, Maria E., additional, Agard, Christian, additional, Ait Abdallah, Nassim, additional, Albert, Alexandra, additional, André, Marc, additional, Bernstein, Elana J., additional, Berthier, Sabine, additional, Bissonnette, Lyne, additional, Bruns, Alessandra, additional, Carreira, Patricia, additional, Casadevall, Marion, additional, Chaigne, Benjamin, additional, Chung, Lorinda, additional, Correia, Chase, additional, Crichi, Benjamin, additional, Denton, Christopher, additional, Domsic, Robyn, additional, Dunne, James V., additional, Dunogue, Bertrand, additional, Fare, Regina, additional, Farge-Bancel, Dominique, additional, Fortin, Paul R., additional, Gordon, Jessica, additional, Granel-Rey, Brigitte, additional, Gyger, Genevieve, additional, Hachulla, Eric, additional, Herrick, Ariane L, additional, Hoa, Sabrina, additional, Ikic, Alena, additional, Jones, Niall, additional, Kafaja, Suzanne, additional, Khalidi, Nader, additional, Lambert, Marc, additional, Launay, David, additional, Maillard, Hélène, additional, Maltez, Nancy, additional, Manning, Joanne, additional, Marie, Isabelle, additional, Martin, Maria, additional, Martin, Thierry, additional, Masetto, Ariel, additional, Maurier, François, additional, Mekinian, Arsene, additional, Melchor, Sheila, additional, Nikpour, Mandana, additional, Olagne, Louis, additional, Poindron, Vincent, additional, Proudman, Susanna, additional, Régent, Alexis, additional, Rivière, Sébastien, additional, Robinson, David, additional, Rodriguez, Esther, additional, Roux, Sophie, additional, Smets, Perrine, additional, Sobanski, Vincent, additional, Spiera, Robert, additional, Steen, Virginia, additional, Sutton, Evelyn, additional, Thorne, Carter, additional, Wilcox, Pearce, additional, Bourgeault, Angelica, additional, Cañedo Ayala, Mara, additional, Carboni Jiménez, Andrea, additional, Discepola, Marie-Nicole, additional, Gagarine, Maria, additional, Nordlund, Julia, additional, and Østbø, Nora, additional

Published
2021
Full Text
View/download PDF

205. Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression: updated systematic review and individual participant data meta-analysis

Author

Negeri, Zelalem F, Levis, Brooke, Sun, Ying, He, Chen, Krishnan, Ankur, Wu, Yin, Bhandari, Parash Mani, Neupane, Dipika, Brehaut, Eliana, Benedetti, Andrea, Thombs, Brett D, Imran, Mahrukh, Rice, Danielle B, Riehm, Kira E, Azar, Marleine, Levis, Alexander W, Boruff, Jill T, Cuijpers, Pim, Gilbody, Simon, Ioannidis, John P A, Kloda, Lorie A, Patten, Scott B, Shrier, Ian, Ziegelstein, Roy C, Markham, Sarah, Alamri, Sultan H, Amtmann, Dagmar, Arroll, Bruce, Ayalon, Liat, Baradaran, Hamid R, Beraldi, Anna, Bernstein, Charles N, Bhana, Arvin, Bombardier, Charles H, Buji, Ryna Imma, Butterworth, Peter, Carter, Gregory, Chagas, Marcos H, Chan, Juliana C N, Chan, Lai Fong, Chibanda, Dixon, Clover, Kerrie, Conway, Aaron, Conwell, Yeates, Daray, Federico M, de Man-van Ginkel, Janneke M, Delgadillo, Jaime, Diez-Quevedo, Crisanto, Fann, Jesse R, Fischer, Felix H, Field, Sally, Fisher, Jane R W, Fung, Daniel, Garman, Emily C, Gelaye, Bizu, Gholizadeh, Leila, Gibson, Lorna J, Goodyear-Smith, Felicity, Green, Eric P, Greeno, Catherine G, Hall, Brian J, Hantsoo, Liisa, Haroz, Emily E, Härter, Martin, Hegerl, Ulrich, Hides, Leanne, Hobfoll, Stevan E, Honikman, Simone, Hudson, Marie, Hyphantis, Thomas, Inagaki, Masatoshi, Jeon, Hong Jin, Jetté, Nathalie, Khamseh, Mohammad E, Kӧhler, Sebastian, Kohrt, Brandon A, Kwan, Yunxin, Lamers, Femke, Lara, Maria Asunción, Levin-Aspenson, Holly F, Liu, Shen-Ing, Lotrakul, Manote, Loureiro, Sonia R, Löwe, Bernd, Luitel, Nagendra P, Lund, Crick, Marrie, Ruth Ann, Marsh, Laura, Marx, Brian P, McGuire, Anthony, Mohd Sidik, Sherina, Munhoz, Tiago N, Muramatsu, Kumiko, Nakku, Juliet E M, Navarrete, Laura, Osório, Flávia L, Pence, Brian W, Persoons, Philippe, Petersen, Inge, Picardi, Angelo, Pugh, Stephanie L, Quinn, Terence J, Rancans, Elmars, Rathod, Sujit D, Reuter, Katrin, Rooney, Alasdair G, Rowe, Heather J, Santos, Iná S, Schram, Miranda T, Shaaban, Juwita, Shinn, Eileen H, Sidebottom, Abbey, Simning, Adam, Spangenberg, Lena, Stafford, Lesley, Sung, Sharon C, Suzuki, Keiko, Tan, Pei Lin Lynnette, Taylor-Rowan, Martin, Tran, Thach D, Turner, Alyna, van der Feltz-Cornelis, Christina M, van Heyningen, Thandi, van Weert, Henk C, Vöhringer, Paul A, Wagner, Lynne I, Wang, Jian Li, Wang, Wenzheng, Watson, David, White, Jennifer, Whooley, Mary A, Winkley, Kirsty, Wynter, Karen, Yamada, Mitsuhiko, Zeng, Qing Zhi, and Zhang, Yuying

Subjects
Adult, Male, medicine.medical_specialty, MEDLINE, PsycINFO, Patient Health Questionnaire, Sex Factors, Medicine, Humans, Mini-international neuropsychiatric interview, Psychiatric Status Rating Scales, Depressive Disorder, Major, business.industry, Research, Age Factors, General Medicine, Middle Aged, Reference Standards, Random effects model, Confidence interval, ROC Curve, Meta-analysis, Family medicine, Structured interview, Female, business
Abstract

ObjectiveTo update a previous individual participant data meta-analysis and determine the accuracy of the Patient Health Questionnaire-9 (PHQ-9), the most commonly used depression screening tool in general practice, for detecting major depression overall and by study or participant subgroups.DesignSystematic review and individual participant data meta-analysis.Data sourcesMedline, Medline In-Process, and Other Non-Indexed Citations via Ovid, PsycINFO, Web of Science searched through 9 May 2018.Review methodsEligible studies administered the PHQ-9 and classified current major depression status using a validated semistructured diagnostic interview (designed for clinician administration), fully structured interview (designed for lay administration), or the Mini International Neuropsychiatric Interview (MINI; a brief interview designed for lay administration). A bivariate random effects meta-analytic model was used to obtain point and interval estimates of pooled PHQ-9 sensitivity and specificity at cut-off values 5-15, separately, among studies that used semistructured diagnostic interviews (eg, Structured Clinical Interview for Diagnostic and Statistical Manual), fully structured interviews (eg, Composite International Diagnostic Interview), and the MINI. Meta-regression was used to investigate whether PHQ-9 accuracy correlated with reference standard categories and participant characteristics.ResultsData from 44 503 total participants (27 146 additional from the update) were obtained from 100 of 127 eligible studies (42 additional studies; 79% eligible studies; 86% eligible participants). Among studies with a semistructured interview reference standard, pooled PHQ-9 sensitivity and specificity (95% confidence interval) at the standard cut-off value of ≥10, which maximised combined sensitivity and specificity, were 0.85 (0.79 to 0.89) and 0.85 (0.82 to 0.87), respectively. Specificity was similar across reference standards, but sensitivity in studies with semistructured interviews was 7-24% (median 21%) higher than with fully structured reference standards and 2-14% (median 11%) higher than with the MINI across cut-off values. Across reference standards and cut-off values, specificity was 0-10% (median 3%) higher for men and 0-12 (median 5%) higher for people aged 60 or older.ConclusionsResearchers and clinicians could use results to determine outcomes, such as total number of positive screens and false positive screens, at different PHQ-9 cut-off values for different clinical settings using the knowledge translation tool atwww.depressionscreening100.com/phq.Study registrationPROSPERO CRD42014010673.

Published
2021

206. Reporting transparency and completeness in Trials: Paper 2 - reporting of randomised trials using registries was often inadequate and hindered the interpretation of results

Author

Mc Cord, Kimberly A, Imran, Mahrukh, Rice, Danielle B, McCall, Stephen J, Kwakkenbos, Linda, Sampson, Margaret, Fröbert, Ole, Gale, Chris, Langan, Sinéad M, Moher, David, Relton, Clare, Zwarenstein, Merrick, Juszczak, Edmund, Thombs, Brett D, Hemkens, Lars G, CONSORT Extension for Trials Conducted Using Cohorts, and Routinely Collected Data Group

Abstract

OBJECTIVE: Registries are important data sources for randomized controlled trials (RCTs), but reporting of how they are used may be inadequate. The objective was to describe the current adequacy of reporting of RCTs using registries. STUDY DESIGN AND SETTING: We used a database of trials using registries from a scoping review supporting the development of the 2021 CONSORT extension for Trials Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE). Reporting completeness of 13 CONSORT-ROUTINE items was assessed. RESULTS: We assessed reports of 47 RCTs that used a registry, published between 2011 and 2018. Of the 13 CONSORT-ROUTINE items, 6 were adequately reported in at least half of reports (2 in at least 80%). The 7 other items were related to routinely collected data source eligibility (32% adequate), data linkage (8% adequate), validation and completeness of data used for outcome assessment (8% adequate), validation and completeness of data used for participant recruitment (0% adequate), participant flow (9% adequate), registry funding (6% adequate) and interpretation of results in consideration of registry use (25% adequate). CONCLUSION: Reporting of trials using registries was often poor, particularly details on data linkage and quality. Better reporting is needed for appropriate interpretation of the results of these trials.

Published
2021

210. Comparison of different scoring methods based on latent variable models of the PHQ-9: an individual participant data meta-analysis.

Author

Fischer, Felix, Levis, Brooke, Falk, Carl, Sun, Ying, Ioannidis, John P. A., Cuijpers, Pim, Shrier, Ian, Benedetti, Andrea, Thombs, Brett D., the Depression Screening Data (DEPRESSD) PHQ Collaboration, He, Chen, Krishnan, Ankur, Wu, Yin, Negeri, Zelalem, Bhandari, Parash Mani, Neupane, Dipika, Rice, Danielle B., Riehm, Kira E., Saadat, Nazanin, and Azar, Marleine

Subjects
MEDICAL screening, MENTAL depression, QUESTIONNAIRES, DESCRIPTIVE statistics, STATISTICAL models, DATA analysis software, SECONDARY analysis
Abstract

Background: Previous research on the depression scale of the Patient Health Questionnaire (PHQ-9) has found that different latent factor models have maximized empirical measures of goodness-of-fit. The clinical relevance of these differences is unclear. We aimed to investigate whether depression screening accuracy may be improved by employing latent factor model-based scoring rather than sum scores. Methods: We used an individual participant data meta-analysis (IPDMA) database compiled to assess the screening accuracy of the PHQ-9. We included studies that used the Structured Clinical Interview for DSM (SCID) as a reference standard and split those into calibration and validation datasets. In the calibration dataset, we estimated unidimensional, two-dimensional (separating cognitive/affective and somatic symptoms of depression), and bi-factor models, and the respective cut-offs to maximize combined sensitivity and specificity. In the validation dataset, we assessed the differences in (combined) sensitivity and specificity between the latent variable approaches and the optimal sum score (⩾10), using bootstrapping to estimate 95% confidence intervals for the differences. Results: The calibration dataset included 24 studies (4378 participants, 652 major depression cases); the validation dataset 17 studies (4252 participants, 568 cases). In the validation dataset, optimal cut-offs of the unidimensional, two-dimensional, and bi-factor models had higher sensitivity (by 0.036, 0.050, 0.049 points, respectively) but lower specificity (0.017, 0.026, 0.019, respectively) compared to the sum score cut-off of ⩾10. Conclusions: In a comprehensive dataset of diagnostic studies, scoring using complex latent variable models do not improve screening accuracy of the PHQ-9 meaningfully as compared to the simple sum score approach. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

213. A study protocol for the development of a SPIRIT extension for trials conducted using cohorts and routinely collected data (SPIRIT-ROUTINE) [version 1; peer review: awaiting peer review]

Author

McCarthy, edMegan, O'Keeffe, Linda, Williamson, Paula R., Sydes, Matthew R., Farrin, Amanda, Lugg-Widger, Fiona, Davies, Gwyneth, Avery, Kerry, Chan, An-Wen, Kwakkenbos, Linda, Thombs, Brett D., Watkins, Alan, Hemkens, Lars G., Gale, Chris, Zwarenstein, Merrick, Langan, Sinead M., Thabane, Lehana, Juszczak, Edmund, Moher, David, and Kearney, Patricia M.

Published
2021

215. Reporting Transparency and Completeness in Trials: Paper 2 - Reporting of randomised trials using registries was often inadequate and hindered the interpretation of results

Author

Cord, Kimberly A. Mc, primary, Imran, Mahrukh, additional, Rice, Danielle B., additional, McCall, Stephen J., additional, Kwakkenbos, Linda, additional, Sampson, Margaret, additional, Fröbert, Ole, additional, Gale, Chris, additional, Langan, Sinéad M., additional, Moher, David, additional, Relton, Clare, additional, Zwarenstein, Merrick, additional, Juszczak, Edmund, additional, and Thombs, Brett D., additional

Published
2021
Full Text
View/download PDF

216. Data-driven methods distort optimal cutoffs and accuracy estimates of depression screening tools: a simulation study using individual participant data

Author

Bhandari, Parash Mani, primary, Levis, Brooke, additional, Neupane, Dipika, additional, Patten, Scott B., additional, Shrier, Ian, additional, Thombs, Brett D., additional, Benedetti, Andrea, additional, Sun, Ying, additional, He, Chen, additional, Rice, Danielle B., additional, Krishnan, Ankur, additional, Wu, Yin, additional, Azar, Marleine, additional, Sanchez, Tatiana A., additional, Chiovitti, Matthew J., additional, Saadat, Nazanin, additional, Riehm, Kira E., additional, Imran, Mahrukh, additional, Negeri, Zelalem, additional, Boruff, Jill T., additional, Cuijpers, Pim, additional, Gilbody, Simon, additional, Ioannidis, John P.A., additional, Kloda, Lorie A., additional, Ziegelstein, Roy C., additional, Comeau, Liane, additional, Mitchell, Nicholas D., additional, Tonelli, Marcello, additional, Vigod, Simone N., additional, Aceti, Franca, additional, Alvarado, Rubén, additional, Alvarado-Esquivel, Cosme, additional, Bakare, Muideen O., additional, Barnes, Jacqueline, additional, Bavle, Amar D., additional, Beck, Cheryl Tatano, additional, Bindt, Carola, additional, Boyce, Philip M., additional, Bunevicius, Adomas, additional, Castro e Couto, Tiago, additional, Chaudron, Linda H., additional, Correa, Humberto, additional, de Figueiredo, Felipe Pinheiro, additional, Eapen, Valsamma, additional, Favez, Nicolas, additional, Felice, Ethel, additional, Fernandes, Michelle, additional, Figueiredo, Barbara, additional, Fisher, Jane R.W., additional, Garcia-Esteve, Lluïsa, additional, Giardinelli, Lisa, additional, Helle, Nadine, additional, Howard, Louise M., additional, Khalifa, Dina Sami, additional, Kohlhoff, Jane, additional, Kozinszky, Zoltán, additional, Kusminskas, Laima, additional, Lelli, Lorenzo, additional, Leonardou, Angeliki A., additional, Maes, Michael, additional, Meuti, Valentina, additional, Radoš, Sandra Nakić, additional, García, Purificación Navarro, additional, Nishi, Daisuke, additional, Luwa E-Andjafono, Daniel Okitundu, additional, Pawlby, Susan J., additional, Quispel, Chantal, additional, Robertson-Blackmore, Emma, additional, Rochat, Tamsen J., additional, Rowe, Heather J., additional, Sharp, Deborah J., additional, Siu, Bonnie W.M., additional, Skalkidou, Alkistis, additional, Stein, Alan, additional, Stewart, Robert C., additional, Su, Kuan-Pin, additional, Sundström-Poromaa, Inger, additional, Tadinac, Meri, additional, Tandon, S. Darius, additional, Tendais, Iva, additional, Thiagayson, Pavaani, additional, Töreki, Annamária, additional, Torres-Giménez, Anna, additional, Tran, Thach D., additional, Trevillion, Kylee, additional, Turner, Katherine, additional, Vega-Dienstmaier, Johann M., additional, Wynter, Karen, additional, and Yonkers, Kimberly A., additional

Published
2021
Full Text
View/download PDF

219. CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration

Author

Kwakkenbos, Linda, Imran, Mahrukh, McCall, Stephen J., McCord, Kimberly A., Hemkens, Lars G., Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B., Benchimol, Eric I., Thabane, Lehana, Campbell, Marion K., Sampson, Margaret, Erlinge, David, Verkooijen, Helena M., Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, Thombs, Brett D., and Juszczak, Edmund

Abstract

Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts or routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants are eligible for the trial and to facilitate recruitment, to deliver an embedded intervention, to collect trial outcome data, or a combination of these purposes. This report presents the Consolidated Standards of Reporting Trials (CONSORT) extension for randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE). The extension was developed to look at the unique characteristics of trials conducted with these types of data with the goal of improving reporting quality in the long term by setting standards early in the process of uptake of these trial designs. The extension was developed with a sequential approach, including a Delphi survey, a consensus meeting, and piloting of the checklist. The checklist was informed by the CONSORT 2010 statement and two reporting guidelines for observational studies, the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and the REporting of studies Conducted using Observational Routinely collected Data (RECORD) statement. The extension includes eight items modified from the CONSORT 2010 statement and five new items. Reporting items with explanations and examples are provided, including key aspects of trials conducted using cohorts or routinely collected data that require specific reporting considerations.

Published
2021

220. Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE)

Author

Imran, Mahrukh, Kwakkenbos, Linda, McCall, Stephen J, McCord, Kimberly A, Hemkens, Lars G, Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B, Benchimol, Eric I, Thabane, Lehana, Campbell, Marion K, Sampson, Margaret, Erlinge, David, Verkooijen, Helena M, Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, and Thombs, Brett D

Subjects
General Medicine
Abstract

Objectives Randomised controlled trials conducted using cohorts and routinely collected data, including registries, electronic health records and administrative databases, are increasingly used in healthcare intervention research. A Consolidated Standards of Reporting Trials (CONSORT) statement extension for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE) has been developed with the goal of improving reporting quality. This article describes the processes and methods used to develop the extension and decisions made to arrive at the final checklist.Methods The development process involved five stages: (1) identification of the need for a reporting guideline and project launch; (2) conduct of a scoping review to identify possible modifications to CONSORT 2010 checklist items and possible new extension items; (3) a three-round modified Delphi study involving key stakeholders to gather feedback on the checklist; (4) a consensus meeting to finalise items to be included in the extension, followed by stakeholder piloting of the checklist; and (5) publication, dissemination and implementation of the final checklist.Results 27 items were initially developed and rated in Delphi round 1, 13 items were rated in round 2 and 11 items were rated in round 3. Response rates for the Delphi study were 92 of 125 (74%) invited participants in round 1, 77 of 92 (84%) round 1 completers in round 2 and 62 of 77 (81%) round 2 completers in round 3. Twenty-seven members of the project team representing a variety of stakeholder groups attended the in-person consensus meeting. The final checklist includes five new items and eight modified items. The extension Explanation & Elaboration document further clarifies aspects that are important to report.ConclusionUptake of CONSORT-ROUTINE and accompanying Explanation & Elaboration document will improve conduct of trials, as well as the transparency and completeness of reporting of trials conducted using cohorts and routinely collected data.

Published
2021

221. Intensity of care and perceived burden among informal caregivers to persons with chronic medical conditions: a systematic review and meta-analysis.

Author

Carboni-Jiménez, Andrea, Rice, Danielle B., Levis, Brooke, Cañedo-Ayala, Mara, Imran, Mahrukh, Chiovitti, Matthew, Benedetti, Andrea, and Thombs, Brett D.

Subjects
CAREGIVER attitudes, MEDICAL databases, CINAHL database, PSYCHOLOGY information storage & retrieval systems, EVALUATION of medical care, META-analysis, MEDICAL information storage & retrieval systems, CONFIDENCE intervals, CHRONIC diseases, SYSTEMATIC reviews, BURDEN of care, PATIENT care, MEDLINE, STATISTICAL sampling, MENTAL illness, EVALUATION
Abstract

Informal caregivers provide ongoing assistance to a loved one with a health condition. No studies have compared caregiving intensity and perception of burden across chronic medical conditions. Databases were searched from inception through 11 September 2020 to identify studies that included the Level of Care Index or the Zarit Burden Inventory (ZBI) among caregivers for people with chronic diseases. Pooled mean ZBI scores and 95% confidence intervals by medical condition were calculated using a random effects model and heterogeneity with I2. Ninety-seven included articles reported on 98 unique samples across 21 chronic diseases. No study used the Level of Care Index. Among 12 disease groups with more than one study, heterogeneity was too high (I2 range: 0–99.6%, ≥76.5% in 11 groups) to confidently estimate burden. The percent of studies rated high risk of bias ranged from 0% to 98%, but all external validity items were rated as high-risk in >50% of studies. Findings highlight the need for studies on caregiver burden to improve sampling techniques; better report sampling procedures and caregiver and care recipient characteristics; and develop a standard set of outcomes, including a measure of caregiving intensity. Systematic Review Registration: CRD42017080962 The amount of burden reported by caregivers to loved ones is associated with reduced physical and mental health. We found considerable heterogeneity in perceived burden reported by informal caregivers across different studies within disease groups, which is likely related to methodological issues, including sampling techniques. Health care providers who use research on caregiver burden should assess how representative study samples may be and exercise caution in drawing conclusions. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

222. Randomized feasibility trial of the Scleroderma Patient-centered Intervention Network hand exercise program (SPIN-HAND).

Author

Kwakkenbos, Linda, Carrier, Marie-Eve, Welling, Joep, Turner, Kimberly A., Cumin, Julie, Pépin, Mia, van den Ende, Cornelia, Schouffoer, Anne A., Hudson, Marie, van Breda, Ward, Sauve, Maureen, Mayes, Maureen D., Malcarne, Vanessa L., Nielson, Warren R., Nguyen, Christelle, Boutron, Isabelle, Rannou, François, Thombs, Brett D., and Mouthon, Luc

Subjects
RANDOMIZED controlled trials, ONLINE education, SEMI-structured interviews, SATISFACTION
Abstract

Purpose. The Scleroderma Patient-centered Intervention Network (SPIN) online hand exercise program (SPIN-HAND), is an online self-help program of hand exercises designed to improve hand function for people with scleroderma. The objective of this feasibility trial was to evaluate aspects of feasibility for conducting a full-scale randomized controlled trial of the SPIN-HAND program. Materials and Methods. The feasibility trial was embedded in the SPIN cohort and utilized the cohort multiple randomized controlled trial (cmRCT) design. In the cmRCT design, at the time of cohort enrollment, cohort participants consent to be assessed for trial eligibility and randomized prior to being informed about trials conducted using the cohort. When trials were conducted in the cohort, participants randomized to the intervention were informed and consented to access the intervention. Participants randomized to control were not informed that they have not received an intervention. All participants eligible and randomized to participate in the trial were included in analyses on an intent-to-treat basis. Cohort participants with a Cochin Hand Function Scale score ≥ 3/90 and an interest in using an online hand-exercise intervention were randomized (1:1 ratio) to be offered as usual care plus the SPINHAND Program or usual care for 3 months. User satisfaction was assessed with semistructured interviews. Results. Of the 40 randomized participants, 24 were allocated to SPIN-HAND and 16 to usual care. Of 24 participants randomized to be offered SPIN-HAND, 15 (63%) consented to use the program. Usage of SPIN-HAND content among the 15 participants who consented to use the program was low; only five (33%) logged in more than twice. Participants found the content relevant and easy to understand (satisfaction rating 8.5/10, N = 6). Automated eligibility and randomization procedures via the SPIN Cohort platform functioned properly. The required technical support was minimal. Conclusions. Trial methodology functioned as designed, and the SPIN-HAND Program was feasibly delivered; however, the acceptance of the offer and use of program content among accepters were low. Adjustments to information provided to potential participants will be implemented in the full-scale SPIN-HAND trial to attempt to increase offer acceptance. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

223. Mental Health Care Use and Associated Factors in Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Study.

Author

Becetti, Karima, Nguyen, Joseph T., Kwakkenbos, Linda, Carrier, Marie‐Eve, Tao, Lydia, Gordon, Jessica K., Mancuso, Carol A., Welling, Joep, Mouthon, Luc, Bartlett, Susan J., Malcarne, Vanessa L., Thombs, Brett D., and Spiera, Robert F.

Subjects
MENTAL health services, BODY image, MEDICAL care use, SYSTEMIC scleroderma, MENTAL health personnel, GENERAL practitioners, COHORT analysis, DISABILITY retirement
Abstract

Objective: Systemic sclerosis (SSc) has significant psychosocial implications. We aimed to evaluate the proportion of participants in a large international SSc cohort who used mental health services in a 3‐month period and to evaluate demographic, psychological, and disease‐specific factors associated with use. Methods: Baseline data of participants enrolled in the Scleroderma Patient‐Centered Intervention Network Cohort were analyzed. We determined the proportion that used mental health services and the source of services in the 3 months prior to enrollment. Multivariable logistic regression was used to identify variables associated with service use. Results: Of the 2319 participants included in the analysis, 417 (18%) used mental health services in the 3 months prior to enrollment. General practitioners were the most common mental health service providers (59%), followed by psychologists (25%) and psychiatrists (19%). In multivariable analysis, mental health service use was independently associated with higher education (odds ratio [OR] 1.07, 95% confidence interval [CI] 1.03‐1.11), smoking (OR 1.06, 95% CI 1.02‐1.11), being retired (OR 0.60, 95% CI 0.38‐0.93), having limited SSc (OR 1.39, 95% CI 1.02‐1.89), and having higher anxiety symptom scores (OR 1.04, 95% CI 1.03‐1.06) and lower self‐efficacy scores (OR 0.90, 95% CI 0.83‐0.97). Variables not significantly associated included age, race, disease manifestations, depression symptom scores, and body image distress. Conclusion: About 18% of participants in a large international cohort received mental health services in a 3‐month period, of whom the majority received these services from a general practitioner. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

228. Comparison of Mental Health Symptom Changes from pre-COVID-19 to COVID-19 by Sex or Gender: A Systematic Review and Meta-analysis

Author

Santo, Tiffany Dal, primary, Sun, Ying, additional, Wu, Yin, additional, He, Chen, additional, Wang, Yutong, additional, Jiang, Xiaowen, additional, Li, Kexin, additional, Bonardi, Olivia, additional, Krishnan, Ankur, additional, Boruff, Jill T., additional, Rice, Danielle B., additional, Markham, Sarah, additional, Levis, Brooke, additional, Azar, Marleine, additional, Neupane, Dipika, additional, Tasleem, Amina, additional, Yao, Anneke, additional, Thombs-Vite, Ian, additional, Agic, Branka, additional, Fahim, Christine, additional, Martin, Michael S., additional, Sockalingam, Sanjeev, additional, Turecki, Gustavo, additional, Benedetti, Andrea, additional, and Thombs, Brett D., additional

Published
2021
Full Text
View/download PDF

232. Comparison of Mental Health Symptoms Prior to and During COVID-19: Evidence from a Systematic Review and Meta-analysis of 134 Cohorts

Author

Sun, Ying, primary, Wu, Yin, additional, Fan, Suiqiong, additional, Santo, Tiffany Dal, additional, Li, Letong, additional, Jiang, Xiaowen, additional, Li, Kexin, additional, Wang, Yutong, additional, Tasleem, Amina, additional, Krishnan, Ankur, additional, He, Chen, additional, Bonardi, Olivia, additional, Boruff, Jill T., additional, Rice, Danielle B., additional, Markham, Sarah, additional, Levis, Brooke, additional, Azar, Marleine, additional, Thombs-Vite, Ian, additional, Neupane, Dipika, additional, Agic, Branka, additional, Fahim, Christine, additional, Martin, Michael S., additional, Sockalingam, Sanjeev, additional, Turecki, Gustavo, additional, Benedetti, Andrea, additional, and Thombs, Brett D., additional

Published
2021
Full Text
View/download PDF

233. Accuracy of the Hospital Anxiety and Depression Scale Depression subscale (HADS-D) to screen for major depression: systematic review and individual participant data meta-analysis

Author

Wu, Yin, primary, Levis, Brooke, additional, Sun, Ying, additional, He, Chen, additional, Krishnan, Ankur, additional, Neupane, Dipika, additional, Bhandari, Parash Mani, additional, Negeri, Zelalem, additional, Benedetti, Andrea, additional, and Thombs, Brett D, additional

Published
2021
Full Text
View/download PDF

234. Effects of COVID-19 Mental Health Interventions among Community-based Children, Adolescents, and Adults: A Living Systematic Review of Randomised Controlled Trials

Author

Bonardi, Olivia, primary, Wang, Yutong, additional, Li, Kexin, additional, Jiang, Xiaowen, additional, Krishnan, Ankur, additional, He, Chen, additional, Sun, Ying, additional, Wu, Yin, additional, Boruff, Jill T., additional, Markham, Sarah, additional, Rice, Danielle B., additional, Thombs-Vite, Ian, additional, Tasleem, Amina, additional, Dal Santo, Tiffany, additional, Yao, Anneke, additional, Azar, Marleine, additional, Agic, Branka, additional, Fahim, Christine, additional, Martin, Michael S., additional, Sockalingam, Sanjeev, additional, Turecki, Gustavo, additional, Benedetti, Andrea, additional, and Thombs, Brett D., additional

Published
2021
Full Text
View/download PDF

235. Effects of non-pharmacological and non-surgical interventions on health outcomes in systemic sclerosis: protocol for a living systematic review

Author

Discepola, Marie-Nicole, primary, Carboni-Jiménez, Andrea, additional, Kwakkenbos, Linda, additional, Henry, Richard S, additional, Boruff, Jill, additional, Krishnan, Ankur, additional, Boström, Carina, additional, Culos-Reed, S Nicole, additional, Hudson, Marie, additional, Leader, David M, additional, Mattsson, Malin, additional, Mouthon, Luc, additional, Wojeck, Robyn, additional, Yakes Jimenez, Elizabeth, additional, Sauve, Maureen, additional, Welling, Joep, additional, Guillot, Geneviève, additional, Benedetti, Andrea, additional, and Thombs, Brett D, additional

Published
2021
Full Text
View/download PDF

236. Intensity of care and perceived burden among informal caregivers to persons with chronic medical conditions: a systematic review and meta-analysis

Author

Carboni-Jiménez, Andrea, Rice, Danielle B., Levis, Brooke, Cañedo-Ayala, Mara, Imran, Mahrukh, Chiovitti, Matthew, Benedetti, Andrea, and Thombs, Brett D.

Abstract

Informal caregivers provide ongoing assistance to a loved one with a health condition. No studies have compared caregiving intensity and perception of burden across chronic medical conditions. Databases were searched from inception through 11 September 2020 to identify studies that included the Level of Care Index or the Zarit Burden Inventory (ZBI) among caregivers for people with chronic diseases. Pooled mean ZBI scores and 95% confidence intervals by medical condition were calculated using a random effects model and heterogeneity with I2. Ninety-seven included articles reported on 98 unique samples across 21 chronic diseases. No study used the Level of Care Index. Among 12 disease groups with more than one study, heterogeneity was too high (I2 range: 0–99.6%, ≥76.5% in 11 groups) to confidently estimate burden. The percent of studies rated high risk of bias ranged from 0% to 98%, but all external validity items were rated as high-risk in >50% of studies. Findings highlight the need for studies on caregiver burden to improve sampling techniques; better report sampling procedures and caregiver and care recipient characteristics; and develop a standard set of outcomes, including a measure of caregiving intensity. Systematic Review Registration: CRD42017080962IMPLICATIONS FOR REHABILITATIONThe amount of burden reported by caregivers to loved ones is associated with reduced physical and mental health.We found considerable heterogeneity in perceived burden reported by informal caregivers across different studies within disease groups, which is likely related to methodological issues, including sampling techniques.Health care providers who use research on caregiver burden should assess how representative study samples may be and exercise caution in drawing conclusions. The amount of burden reported by caregivers to loved ones is associated with reduced physical and mental health. We found considerable heterogeneity in perceived burden reported by informal caregivers across different studies within disease groups, which is likely related to methodological issues, including sampling techniques. Health care providers who use research on caregiver burden should assess how representative study samples may be and exercise caution in drawing conclusions.

Published
2021
Full Text
View/download PDF

237. Additional file 3 of Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

Author

Gates, Allison, Pillay, Jennifer, Reynolds, Donna, Stirling, Rob, Traversy, Gregory, Korownyk, Christina, Moore, Ainsley, Thériault, Guylène, Thombs, Brett D., Little, Julian, Popadiuk, Catherine, Niekerk, Dirk Van, Keto-Lambert, Diana, Vandermeer, Ben, and Hartling, Lisa

Subjects
Data_FILES
Abstract

Additional file 3. Methodological Details.

Published
2021
Full Text
View/download PDF

238. Additional file 1 of Screening for depression in children and adolescents: a protocol for a systematic review update

Author

Beck, Andrew, LeBlanc, John C., Morissette, Kate, Hamel, Candyce, Skidmore, Becky, Colquhoun, Heather, Lang, Eddy, Moore, Ainsley, Riva, John J., Thombs, Brett D., Patten, Scott, Bragg, Heather, Colman, Ian, Goldfield, Gary S., Nicholls, Stuart Gordon, Pajer, Kathleen, Potter, Beth K., Meeder, Robert, Vasa, Priya, Hutton, Brian, Shea, Beverley J., Graham, Eva, Little, Julian, Moher, David, and Stevens, Adrienne

Abstract

Additional file 1:. DSM-5 and ICD-10 definition of MDE.docx (19 KB)

Published
2021
Full Text
View/download PDF

239. Additional file 1 of Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

Author

Gates, Allison, Pillay, Jennifer, Reynolds, Donna, Stirling, Rob, Traversy, Gregory, Korownyk, Christina, Moore, Ainsley, Thériault, Guylène, Thombs, Brett D., Little, Julian, Popadiuk, Catherine, Niekerk, Dirk Van, Keto-Lambert, Diana, Vandermeer, Ben, and Hartling, Lisa

Abstract

Additional file 1. PRISMA-P Checklist.

Published
2021
Full Text
View/download PDF

240. Additional file 6 of Screening for depression in children and adolescents: a protocol for a systematic review update

Author

Beck, Andrew, LeBlanc, John C., Morissette, Kate, Hamel, Candyce, Skidmore, Becky, Colquhoun, Heather, Lang, Eddy, Moore, Ainsley, Riva, John J., Thombs, Brett D., Patten, Scott, Bragg, Heather, Colman, Ian, Goldfield, Gary S., Nicholls, Stuart Gordon, Pajer, Kathleen, Potter, Beth K., Meeder, Robert, Vasa, Priya, Hutton, Brian, Shea, Beverley J., Graham, Eva, Little, Julian, Moher, David, and Stevens, Adrienne

Abstract

Additional file 6:. Stakeholder and peer review feedback.docx (24 KB)

Published
2021
Full Text
View/download PDF

241. Additional file 5 of Screening for depression in children and adolescents: a protocol for a systematic review update

Author

Beck, Andrew, LeBlanc, John C., Morissette, Kate, Hamel, Candyce, Skidmore, Becky, Colquhoun, Heather, Lang, Eddy, Moore, Ainsley, Riva, John J., Thombs, Brett D., Patten, Scott, Bragg, Heather, Colman, Ian, Goldfield, Gary S., Nicholls, Stuart Gordon, Pajer, Kathleen, Potter, Beth K., Meeder, Robert, Vasa, Priya, Hutton, Brian, Shea, Beverley J., Graham, Eva, Little, Julian, Moher, David, and Stevens, Adrienne

Abstract

Additional file 5:. Draft data extraction form.docx (16 KB)

Published
2021
Full Text
View/download PDF

242. Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis

Author

Lyubenova, Anita Neupane, Dipika Levis, Brooke Wu, Yin and Sun, Ying He, Chen Krishnan, Ankur Bhandari, Parash M. and Negeri, Zelalem Imran, Mahrukh Rice, Danielle B. Azar, Marleine Chiovitti, Matthew J. Saadat, Nazanin Riehm, Kira E. Boruff, Jill T. Ioannidis, John P. A. Cuijpers, Pim and Gilbody, Simon Kloda, Lorie A. Patten, Scott B. Shrier, Ian and Ziegelstein, Roy C. Comeau, Liane Mitchell, Nicholas D. and Tonelli, Marcello Vigod, Simone N. Aceti, Franca Barnes, Jacqueline Bavle, Amar D. Beck, Cheryl T. Bindt, Carola and Boyce, Philip M. Bunevicius, Adomas Chaudron, Linda H. and Favez, Nicolas Figueiredo, Barbara Garcia-Esteve, Lluisa and Giardinelli, Lisa Helle, Nadine Howard, Louise M. Kohlhoff, Jane Kusminskas, Laima Kozinszky, Zoltan Lelli, Lorenzo and Leonardou, Angeliki A. Meuti, Valentina Rados, Sandra N. and Garcia, Purificacion N. Pawlby, Susan J. Quispel, Chantal and Robertson-Blackmore, Emma Rochat, Tamsen J. Sharp, Deborah J. and Siu, Bonnie W. M. Stein, Alan Stewart, Robert C. and Tadinac, Meri Tandon, S. Darius Tendais, Iva Toreki, Annamaria Torres-Gimenez, Anna Tran, Thach D. Trevillion, Kylee Turner, Katherine Vega-Dienstmaier, Johann M. and Benedetti, Andrea Thombs, Brett D.

Abstract

Objectives Estimates of depression prevalence in pregnancy and postpartum are based on the Edinburgh Postnatal Depression Scale (EPDS) more than on any other method. We aimed to determine if any EPDS cutoff can accurately and consistently estimate depression prevalence in individual studies. Methods We analyzed datasets that compared EPDS scores to Structured Clinical Interview for DSM (SCID) major depression status. Random-effects meta-analysis was used to compare prevalence with EPDS cutoffs versus the SCID. Results Seven thousand three hundred and fifteen participants (1017 SCID major depression) from 29 primary studies were included. For EPDS cutoffs used to estimate prevalence in recent studies (>= 9 to >= 14), pooled prevalence estimates ranged from 27.8% (95% CI: 22.0%-34.5%) for EPDS >= 9 to 9.0% (95% CI: 6.8%-11.9%) for EPDS >= 14; pooled SCID major depression prevalence was 9.0% (95% CI: 6.5%-12.3%). EPDS >= 14 provided pooled prevalence closest to SCID-based prevalence but differed from SCID prevalence in individual studies by a mean absolute difference of 5.1% (95% prediction interval: -13.7%, 12.3%). Conclusion EPDS >= 14 approximated SCID-based prevalence overall, but considerable heterogeneity in individual studies is a barrier to using it for prevalence estimation.

Published
2021

243. Additional file 1 of Fall prevention interventions for older community-dwelling adults: systematic reviews on benefits, harms, and patient values and preferences

Author

Pillay, Jennifer, Riva, John J., Tessier, Laure A., Colquhoun, Heather, Lang, Eddy, Moore, Ainsley E., Thombs, Brett D., Wilson, Brenda J., Tzenov, Amanda, Donnelly, Catherine, Émond, Marcel, Jayna Holroyd-Leduc, Milligan, Jamie, Keto-Lambert, Diana, Rahman, Sholeh, Vandermeer, Ben, Tricco, Andrea C., Straus, Sharon E., Thomas, Sonia M., Mitchelmore, Bradley R., Rolland-Harris, Elizabeth, and Hartling, Lisa

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
Full Text
View/download PDF

245. Additional file 5 of Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

Author

Gates, Allison, Pillay, Jennifer, Reynolds, Donna, Stirling, Rob, Traversy, Gregory, Korownyk, Christina, Moore, Ainsley, Thériault, Guylène, Thombs, Brett D., Little, Julian, Popadiuk, Catherine, Niekerk, Dirk Van, Keto-Lambert, Diana, Vandermeer, Ben, and Hartling, Lisa

Abstract

Additional file 5. Search Strategies for Key Questions 1, 2 and 4.

Published
2021
Full Text
View/download PDF

246. Additional file 2 of Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

Author

Gates, Allison, Pillay, Jennifer, Reynolds, Donna, Stirling, Rob, Traversy, Gregory, Korownyk, Christina, Moore, Ainsley, Thériault, Guylène, Thombs, Brett D., Little, Julian, Popadiuk, Catherine, Niekerk, Dirk Van, Keto-Lambert, Diana, Vandermeer, Ben, and Hartling, Lisa

Abstract

Additional file 2. Outcome Definitions and Baseline Risks.

Published
2021
Full Text
View/download PDF

247. Additional file 4 of Screening for depression in children and adolescents: a protocol for a systematic review update

Author

Beck, Andrew, LeBlanc, John C., Morissette, Kate, Hamel, Candyce, Skidmore, Becky, Colquhoun, Heather, Lang, Eddy, Moore, Ainsley, Riva, John J., Thombs, Brett D., Patten, Scott, Bragg, Heather, Colman, Ian, Goldfield, Gary S., Nicholls, Stuart Gordon, Pajer, Kathleen, Potter, Beth K., Meeder, Robert, Vasa, Priya, Hutton, Brian, Shea, Beverley J., Graham, Eva, Little, Julian, Moher, David, and Stevens, Adrienne

Abstract

Additional file 4:. Draft screening forms.docx (19 KB)

Published
2021
Full Text
View/download PDF

248. Additional file 6 of Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

Author

Gates, Allison, Pillay, Jennifer, Reynolds, Donna, Stirling, Rob, Traversy, Gregory, Korownyk, Christina, Moore, Ainsley, Thériault, Guylène, Thombs, Brett D., Little, Julian, Popadiuk, Catherine, Niekerk, Dirk Van, Keto-Lambert, Diana, Vandermeer, Ben, and Hartling, Lisa

Subjects
Data_FILES
Abstract

Additional file 6. Data Extraction Items for Each Key Question.

Published
2021
Full Text
View/download PDF

249. Additional file 3 of Screening for depression in children and adolescents: a protocol for a systematic review update

Author

Beck, Andrew, LeBlanc, John C., Morissette, Kate, Hamel, Candyce, Skidmore, Becky, Colquhoun, Heather, Lang, Eddy, Moore, Ainsley, Riva, John J., Thombs, Brett D., Patten, Scott, Bragg, Heather, Colman, Ian, Goldfield, Gary S., Nicholls, Stuart Gordon, Pajer, Kathleen, Potter, Beth K., Meeder, Robert, Vasa, Priya, Hutton, Brian, Shea, Beverley J., Graham, Eva, Little, Julian, Moher, David, and Stevens, Adrienne

Abstract

Additional file 3:. Search strategies.docx (27 KB)

Published
2021
Full Text
View/download PDF

250. Additional file 2 of Screening for depression in children and adolescents: a protocol for a systematic review update

Author

Beck, Andrew, LeBlanc, John C., Morissette, Kate, Hamel, Candyce, Skidmore, Becky, Colquhoun, Heather, Lang, Eddy, Moore, Ainsley, Riva, John J., Thombs, Brett D., Patten, Scott, Bragg, Heather, Colman, Ian, Goldfield, Gary S., Nicholls, Stuart Gordon, Pajer, Kathleen, Potter, Beth K., Meeder, Robert, Vasa, Priya, Hutton, Brian, Shea, Beverley J., Graham, Eva, Little, Julian, Moher, David, and Stevens, Adrienne

Abstract

Additional file 2:. PRISMA-P 2015 checklist.docx (21 KB)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results