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8,538 results on '"Tani P"'

201. The emerging emetogenicity of trifluridine/tipiracil (TAS‑102) from patient self-reporting: a multicenter, prospective, observational study

Author: Fujii, Hironori, Tsuchiya, Masami, Watanabe, Daichi, Otsuka, Ryo, Hirate, Daisuke, Takahashi, Katsuyuki, Go, Makiko, Kudo, Toshihiro, Shimomura, Kazuhiro, Ando, Yosuke, Tani, Shinya, Takahashi, Takao, Hayashi, Katsuhisa, Chin, Miki, Matsunami, Naomi, Takahashi, Masaya, Hasegawa, Akiko, Uchida, Takashi, Hashimoto, Hironobu, Kubo, Akiko, Matsuhashi, Nobuhisa, Suzuki, Akio, Nishimura, Junichi, Inui, Naoki, and Iihara, Hirotoshi
Published: 2024
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202. Meaningful Encounters with the Built Environment as the Basis for Urban Environmental Education

Author: Hilander, Markus and Tani, Sirpa
Abstract: As the majority of people in the world now live in cities, it makes sense to question the state of urban environmental education and how it could be developed going forward. In this article, we suggest a way forward based on the essays written by Finnish university students. The students reflected on their relationship with an environment that is meaningful to them. In the essays selected for this case study (n = 25), the built environment of Helsinki--the capital of Finland--and its characteristics are in focus. In this qualitative research, inductive content analysis was used for processing the essays. Many students described the connections between urban nature and built environments, but the results also show that the built environment is especially significant because of its social and cultural aspects. Students described the importance of social bonding and how meeting different sorts of people supports their acceptance of diverse perspectives. Personal experiences and meanings attached to the city, as well as their lack, were mentioned; that is, without these personal bonds, meaningful relations to urban environments cannot be developed. Architecture, aesthetics, and soundscapes were also mentioned. In addition, it was expressed that feeling safe in the built environment is important. In urban environmental education, it is therefore important to pay attention to the social and cultural aspects, too, and not just to the ecological dimension. It is crucial that children and young people have access to the city in order to construct their personal relationships with the built environment.
Published: 2022

203. Submodular Hypergraph Partitioning: Metric Relaxations and Fast Algorithms via an Improved Cut-Matching Game

Author: Chen, Antares, Orecchia, Lorenzo, and Tani, Erasmo
Subjects: Computer Science - Data Structures and Algorithms, Computer Science - Discrete Mathematics, G.2.1, G.2.2, F.2.0
Abstract: Despite there being significant work on developing spectral, and metric embedding based approximation algorithms for hypergraph generalizations of conductance, little is known regarding the approximability of hypergraph partitioning objectives beyond this. This work proposes algorithms for a general model of hypergraph partitioning that unifies both undirected and directed versions of many well-studied partitioning objectives. The first contribution of this paper introduces polymatroidal cut functions, a large class of cut functions amenable to approximation algorithms via metric embeddings and routing multicommodity flows. We demonstrate an $O(\sqrt{\log n})$-approximation, where $n$ is the number of vertices in the hypergraph, for these problems by rounding relaxations to metrics of negative-type. The second contribution of this paper generalizes the cut-matching game framework of Khandekar et. al. to tackle polymatroidal cut functions. This yields the first almost-linear time $O(\log n)$-approximation algorithm for standard versions of undirected and directed hypergraph partitioning. A technical consequence of our construction is that a cut-matching game which greatly relaxes the set of allowed actions for both players can be used to partition hypergraphs with negligible impact on the approximation ratio. We believe this to be of independent interest., Comment: Comments and feedback welcome
Published: 2023

204. Probabilistic unitary synthesis with optimal accuracy

Author: Akibue, Seiseki, Kato, Go, and Tani, Seiichiro
Subjects: Quantum Physics, Mathematical Physics
Abstract: The purpose of unitary synthesis is to find a gate sequence that optimally approximates a target unitary transformation. A new synthesis approach, called probabilistic synthesis, has been introduced, and its superiority has been demonstrated over traditional deterministic approaches with respect to approximation error and gate length. However, the optimality of current probabilistic synthesis algorithms is unknown. We obtain the tight lower bound on the approximation error obtained by the optimal probabilistic synthesis, which guarantees the sub-optimality of current algorithms. We also show its tight upper bound, which improves and unifies current upper bounds depending on the class of target unitaries. These two bounds reveal the fundamental relationship of approximation error between probabilistic approximation and deterministic approximation of unitary transformations. From a computational point of view, we show that the optimal probability distribution can be computed by the semidefinite program (SDP) we construct. We also construct an efficient probabilistic synthesis algorithm for single-qubit unitaries, rigorously estimate its time complexity, and show that it reduces the approximation error quadratically compared with deterministic algorithms., Comment: 27 pages, 6 figures
Published: 2023
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205. Angular distribution of $\gamma$-rays from a neutron-induced $p$-wave resonance of $^{132}$Xe

Author: Okudaira, T., Tani, Y., Endo, S., Doskow, J., Fujioka, H., Hirota, K., Kameda, K., Kimura, A., Kitaguchi, M., Luxnat, M., Sakai, K., Schaper, D., Shima, T., Shimizu, H. M., Snow, W. M., Takada, S., Yamamoto, T., Yoshikawa, H., and Yoshioka, T.
Subjects: Nuclear Experiment
Abstract: A neutron-energy dependent angular distribution was measured for individual $\gamma$-rays from the 3.2 eV $p$-wave resonance of $^{131}$Xe+$n$, that shows enhanced parity violation owing to a mixing between $s$- and $p$-wave amplitudes. The $\gamma$-ray transitions from the $p$-wave resonance were identified, and the angular distribution with respect to the neutron momentum was evaluated as a function of the neutron energy for 7132 keV $\gamma$-rays, which correspond to a transition to the 1807 keV excited state of $^{132}$Xe. The angular distribution is considered to originate from the interference between $s$- and $p$-wave amplitudes, and will provide a basis for a quantitative understanding of the enhancement mechanism of the fundamental parity violation in compound nuclei.
Published: 2022
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206. Selective 3-dimensional patterning during phase separation of a continuously laminated layer

Author: Ishikawa, Rikuya, Tani, Marie, and Kurita, Rei
Subjects: Condensed Matter - Soft Condensed Matter
Abstract: Control over the physical properties of materials is ubiquitously required in many fields. One means by which this can be achieved is controlling the internal structure of multi-component materials with an eye to enhancing mechanical properties. Here, we focus on self-organized pattern formation in phase separating materials, where microscopic patterns with a smooth, continuous connection may be realized. We propose a feasible method to control pattern formation using phase separation combined with continuous ``lamination'' of material, when material is continuously and homogeneously layered on top of a base. We find that a random droplet pattern, a lamellar pattern, and a cylindrical pattern are formed depending on the lamination rate $V$. We clarify the dynamics of pattern formation, focusing on the mechanism. This study may lead to the creation of new functional materials through artificial pattern control.
Published: 2022
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207. Initial treatment efficacy and safety of durvalumab plus tremelimumab combination therapy in unresectable hepatocellular carcinoma in clinical practice

Author: Tetsu Tomonari, Joji Tani, Yasushi Sato, Hironori Tanaka, Akihiro Morishita, Koichi Okamoto, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto, and Tetsuji Takayama
Subjects: durvalumab, hepatocellular carcinoma, tremelimumab, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Abstract Background and Aims We aimed to evaluate the efficacy and safety of durvalumab plus tremelimumab (Dur + Tre) combination therapy in patients with unresectable hepatocellular carcinoma (uHCC) in clinical practice. Methods We retrospectively evaluated 37 patients with uHCC from our institutions between April 2023 and January 2024. Patients were divided into first‐ and later‐line groups for analysis of antitumor efficacy, adverse events (AEs), and transition rate to second‐line treatment according to the Response Evaluation Criteria in Solid Tumors (RECIST). Results The disease control rate (DCR) for the first‐line group was 80.9%, which was significantly higher than that for the later‐line group (50%). The incidence of immune‐related AEs (irAEs) was 24.3%, with grade 3 or higher irAEs including increased transaminase (8.1%), diarrhea (8.1%), and adrenal insufficiency (2.7%). The rates of drug withdrawal and discontinuation owing to AEs were 23.8% and 19%, respectively, in the first‐line treatment and 31.2% and 12.5%, respectively, in the later‐line treatment, with no significant difference. Analysis of changes in liver reserve using the albumin–bilirubin (ALBI) score showed no obvious loss of liver reserve for up to 12 weeks. The transition rate from first‐ to second‐line therapy after progressive disease (PD) was as high as 94.7%. Conclusion The efficacy and safety of Dur + Tre in clinical practice were comparable to those reported in a recent phase III trial. The first‐line Dur + Tre therapy had a higher DCR than that of the later lines, and the transition rate to second‐line therapy was considerably high, suggesting that Dur + Tre therapy would be more beneficial in first‐line treatment.
Published: 2024
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208. Somatic mutation rates scale with time not growth rate in long-lived tropical trees

Author: Akiko Satake, Ryosuke Imai, Takeshi Fujino, Sou Tomimoto, Kayoko Ohta, Mohammad Na'iem, Sapto Indrioko, Widiyatno Widiyatno, Susilo Purnomo, Almudena Molla Morales, Viktoria Nizhynska, Naoki Tani, Yoshihisa Suyama, Eriko Sasaki, and Masahiro Kasahara
Subjects: somatic mutation, mutational spectrum, genetic diversity, tropical ecosystems, shorea, Medicine, Science, Biology (General), QH301-705.5
Abstract: The rates of appearance of new mutations play a central role in evolution. However, mutational processes in natural environments and their relationship with growth rates are largely unknown, particular in tropical ecosystems with high biodiversity. Here, we examined the somatic mutation landscapes of two tropical trees, Shorea laevis (slow-growing) and S. leprosula (fast-growing), in central Borneo, Indonesia. Using newly constructed genomes, we identified a greater number of somatic mutations in tropical trees than in temperate trees. In both species, we observed a linear increase in the number of somatic mutations with physical distance between branches. However, we found that the rate of somatic mutation accumulation per meter of growth was 3.7-fold higher in S. laevis than in S. leprosula. This difference in the somatic mutation rate was scaled with the slower growth rate of S. laevis compared to S. leprosula, resulting in a constant somatic mutation rate per year between the two species. We also found that somatic mutations are neutral within an individual, but those mutations transmitted to the next generation are subject to purifying selection. These findings suggest that somatic mutations accumulate with absolute time and older trees have a greater contribution towards generating genetic variation.
Published: 2024
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209. Accumulation of mitochondrial DNA with a point mutation in tRNALeu(UUR) gene induces brain dysfunction in mice

Author: Kaori Ishikawa, Daiki Miyata, Satoko Hattori, Haruna Tani, Takayoshi Kuriyama, Fan-Yan Wei, Tsuyoshi Miyakawa, and Kazuto Nakada
Subjects: Mitochondrial DNA, Brain dysfunction, MtDNA tRNALeu(UUR), Prepulse inhibition, Environmental factors, Memory, Therapeutics. Pharmacology, RM1-950
Abstract: Brain functions are mediated via the complex interplay between several complex factors, and hence, identifying the underlying cause of an abnormality within a certain brain region can be challenging. In mitochondrial disease, abnormalities in brain function are thought to be attributed to accumulation of mitochondrial DNA (mtDNA) with pathogenic mutations; however, only few previous studies have directly demonstrated that accumulation of mutant mtDNA induced abnormalities in brain function. Herein, we examined the effects of mtDNA mutations on brain function via behavioral analyses using a mouse model with an A2748G point mutation in mtDNA tRNALeu(UUR). Our results revealed that mice with a high percentage of mutant mtDNA showed a characteristic trend toward reduced prepulse inhibition and memory-dependent test performance, similar to that observed in psychiatric disorders, such as schizophrenia; however, muscle strength and motor coordination were not markedly affected. Upon examining the hippocampus and frontal lobes of the brain, mitochondrial morphology was abnormal, and the brain weight was slightly reduced. These results indicate that the predominant accumulation of a point mutation in the tRNALeu(UUR) gene may affect brain functions, particularly the coordination of sensory and motor functions and memory processes. These abnormalities probably caused by both direct effects of accumulation of the mutant mtDNA in neuronal cells and indirect effects via changes of systemic extracellular environments. Overall, these findings will lead to a better understanding of the pathogenic mechanism underlying this complex disease and facilitate the development of optimal treatment methods.
Published: 2024
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210. Measurement of the production cross section of a Higgs boson with large transverse momentum in its decays to a pair of τ leptons in proton-proton collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M.A. Mahmoud, Y. Mohammed, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. Meena, G. Saha, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, D. Chokheli, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, U. Sarkar, V. Sarkisovi, A. Schmidt, A. Sharma, J.L. Spah, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, A. Mussgiller, L.P. Nair, A. Nürnberg, Y. Otarid, J. Park, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, M. Shchedrolosiev, R.E. Sosa Ricardo, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. Koppenhöfer, J.M. Lawhorn, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, M. Presilla, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H.J. Simonis, M. Toms, N. Trevisani, R. Ulrich, R.F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, S. Wunsch, X. Zuo, G. Anagnostou, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M.M.A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, G.I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S.B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, A. Kaur, H. Kaur, M. Kaur, S. Kumar, K. Sandeep, T. Sheokand, J.B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B.C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Baradia, S. Barman, S. Dutta, P. Palit, S. Sarkar, M.M. Ameen, P.K. Behera, S.C. Behera, P. Jana, P. Kalbhor, J.R. Komaragiri, D. Kumar, L. Panwar, P.R. Pujahari, N.R. Saha, A.K. Sikdar, S. Verma, S. Dugad, M. Kumar, G.B. Mohanty, P. Suryadevara, A. Bala, S. Banerjee, R.M. Chatterjee, M. Guchait, Sh. Jain, S. Karmakar, G. Majumder, K. Mazumdar, S. Parolia, A. Thachayath, S. Bahinipati, A.K. Das, C. Kar, D. Maity, P. Mal, T. Mishra, V.K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, P. Sadangi, P. Saha, S.K. Swain, S. Varghese, D. Vats, S. Acharya, A. Alpana, S. Dube, B. Gomber, B. Kansal, A. Laha, B. Sahu, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S.M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, A. Colaleo, D. Creanza, B. D'Anzi, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, L. Fiore, G. Iaselli, M. Louka, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, G. Ramirez-Sanchez, D. Ramos, A. Ranieri, L. Silvestris, F.M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, R. Campanini, P. Capiluppi, A. Castro, F.R. Cavallo, M. Cuffiani, G.M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F.L. Navarria, A. Perrotta, F. Primavera, A.M. Rossi, T. Rovelli, G.P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, P. Assiouras, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D'Alessandro, E. Focardi, T. Kello, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. 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Bryson, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, I. Azhgirey, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, M. Chadeeva, V. Chekhovsky, R. Chistov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, R. Ryutin, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Volkov, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Higgs boson, Tau lepton, Physics, QC1-999
Abstract: A measurement of the production cross section of a Higgs boson with transverse momentum greater than 250GeV is presented where the Higgs boson decays to a pair of τ leptons. It is based on proton-proton collision data collected by the CMS experiment at the CERN LHC at a center-of-mass energy of 13TeV. The data sample corresponds to an integrated luminosity of 138fb−1. Because of the large transverse momentum of the Higgs boson the τ leptons from its decays are boosted and produced spatially close, with their decay products overlapping. Therefore, a dedicated algorithm was developed to reconstruct and identify them. The observed (expected) significance of the measured signal with respect to the standard model background-only hypothesis is 3.5 (2.2) standard deviations. The product of the production cross section and branching fraction is measured to be 1.64−0.54+0.68 times the standard model expectation. The fiducial differential production cross section is also measured as functions of the Higgs boson and leading jet transverse momenta. This measurement extends the probed large-transverse-momentum region in the ττ final state beyond 600GeV.
Published: 2024
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211. KS0 and Λ(Λ‾) two-particle femtoscopic correlations in PbPb collisions at sNN=5.02TeV

Author: A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E.S. Bols, J. D'Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, A. Morton, D. Müller, A.R. Sahasransu, S. Tavernier, W. Van Doninck, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, A. Taliercio, T.T. Tran, P. Vischia, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, A.A. Abdelalim, E. Salama, M.A. Mahmoud, Y. Mohammed, S. Bhowmik, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, G. Bourgatte, J.-M. Brom, E.C. Chabert, C. Collard, D. Darej, U. 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Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, J. Lidrych, G. Madigan, B. Marzocchi, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K.A. Hahn, Y. Liu, N. Odell, M.H. Schmitt, M. Velasco, R. Band, R. Bucci, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J.F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, H. Wang, H. Acharya, A.G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, M. Chadeeva, V. Chekhovsky, M. Danilov, A. Dermenev, T. Dimova, I. Dremin, V. Epshteyn, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, A. Kaminskiy, L. Kardapoltsev, V. Karjavine, A. Karneyeu, L. Khein, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, O. Kodolova, D. Konstantinov, V. Korenkov, V. Korotkikh, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, A. Litomin, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, I. Ovtin, V. Palichik, V. Perelygin, S. Petrushanko, V. Popov, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, I. Vardanyan, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Heavy ion, V0, Femtoscopy, Scattering parameters, Physics, QC1-999
Abstract: Two-particle correlations are presented for KS0, Image 1, and Image 2 strange hadrons as a function of relative momentum in lead-lead collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV. The dataset corresponds to an integrated luminosity of 0.607nb−1 and was collected using the CMS detector at the CERN LHC. These correlations are sensitive to quantum statistics and to final-state interactions between the particles. The source size extracted from the KS0KS0 correlations is found to decrease from 4.6 to 1.6fm in going from central to peripheral collisions. Strong interaction scattering parameters (i.e., scattering length and effective range) are determined from the Image 3 and Image 4 (including their charge conjugates) correlations using the Lednický–Lyuboshitz model and are compared to theoretical and other experimental results.
Published: 2024
Full Text: View/download PDF

212. Searches for violation of Lorentz invariance in top quark pair production using dilepton events in 13 TeV proton-proton collisions

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Clerbaux, A.K. Das, G. De Lentdecker, L. Favart, P. Gianneios, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, K. Mota Amarilo, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, L. Mundim, H. Nogima, J.P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, A. Lotfy, M.A. Mahmoud, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, K.T.S. Kallonen, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. Meena, G. Saha, M.A. Sessini, P. 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Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, S. Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Top quark, Beyond standard model, Lorentz symmetry, Physics, QC1-999
Abstract: A search for violation of Lorentz invariance in the production of top quark pairs (tt‾) is presented. The measured normalized differential tt‾ production cross section, as a function of the sidereal time, is examined for potential modulations induced by Lorentz-invariance breaking operators in an effective field theory extension of the standard model (SM). The cross section is measured from collision events collected by the CMS detector at a center-of-mass-energy of 13 TeV, corresponding to an integrated luminosity of 77.8 fb−1, and containing one electron and one muon. The results are found to be compatible with zero, in agreement with the SM, and are used to place upper limits at 68% confidence level on the magnitude of the Lorentz-violating couplings ranging from 1–8×10−3. This is the first precision test of the isotropy in special relativity with top quarks at the LHC, restricting further the bounds on such couplings by up to two orders of magnitude with respect to previous searches conducted at the Tevatron.
Published: 2024
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213. The potential effect of romosozumab on perioperative management for instrumentation surgery

Author: Koji Ishikawa, Soji Tani, Tomoaki Toyone, Koki Tsuchiya, Tomoko Towatari, Yusuke Oshita, Ryo Yamamura, Kazuki Wada, Takashi Nagai, Toshiyuki Shirahata, Katsunori Inagaki, and Kudo Yoshifumi
Subjects: aging, biomechanics, imaging, osteoporosis, Orthopedic surgery, RD701-811
Abstract: Abstract Background Age‐related changes in bone health increase the risk for complications in elderly patients undergoing orthopedic surgery. Osteoporosis is a key therapeutic target that needs to be addressed to ensure successful instrumentation surgery. The effectiveness of pharmacological interventions in orthopedic surgery, particularly the new drug romosozumab, is still unknown. We aim to evaluate the effect of 3‐month romosozumab treatment on biomechanical parameters related to spinal instrumentation surgery, using the Quantitative Computed Tomography (QCT)‐based Finite Element Method (FEM). Methods This open‐labeled, prospective study included 81 patients aged 60 to 90 years, who met the osteoporosis criteria and were scheduled for either romosozumab or eldecalcitol treatment. Patients were assessed using blood samples, dual‐energy absorptiometry (DXA), and QCT. Biomechanical parameters were evaluated using FEM at baseline and 3 months post‐treatment. The primary endpoints were biomechanical parameters at 3 months, while secondary endpoints included changes in regional volumetric bone mineral density around the pedicle (P‐vBMD) and vertebral body (V‐vBMD). Results Romosozumab treatment led to significant gains in P‐vBMD, and V‐vBMD compared to eldecalcitol at 3 months. Notably, the romosozumab group showed greater improvements in all biomechanical parameters estimated by FEM at 3 months compared to the eldecalcitol group. Conclusion Romosozumab significantly increased the regional vBMD as well as biomechanical parameters, potentially offering clinical benefits in reducing post‐operative complications in patients with osteoporosis undergoing orthopedic instrumentation surgery. This study highlights the novel advantages of romosozumab treatment and advocates further research on its effectiveness in perioperative management.
Published: 2024
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214. A case report of feline mast cell tumour with intertumoral heterogeneity: Identification of secondary mutations c.998G>C and c.2383G>C in KIT after resistance to toceranib

Author: Hiroyuki Tani, Tatsuro Hifumi, Keita Ito, Tomohide Kuramoto, Noriaki Miyoshi, Makoto Fujiki, and Tomohiro Nakayama
Subjects: acquired resistance, cat, heterogeneity, KIT mutation, mast cell tumour, resistance to toceranib, Veterinary medicine, SF600-1100
Abstract: Abstract A 12‐year‐old male domestic cat with multiple subcutaneous mast cell tumours (MCTs) presented with a 2‐week history of pruritus and raw/bleeding skin from self‐trauma at Kagoshima University Veterinary Teaching Hospital. Polymerase chain reaction (PCR) and histopathological analyses revealed intertumoral heterogeneity among tumour locations based on the mutation status of KIT. In addition, the expression pattern of KIT was characterized. After failed treatment with vinblastine (2.0–2.2 mg/m2, intravenous administration, two doses in total) or nimustine (25 mg/m2, intravenous administration, two doses in total), toceranib (2.2–2.6 mg/kg, orally administered, every other day) was administered to treat recurrent MCTs harbouring the KIT exon eight internal tandem duplication mutation, achieving a complete response. However, toceranib resistance developed 2 months after treatment initiation. Subsequent PCR analysis was conducted to identify the mutational status of KIT in each MCT and to detect the presence of secondary mutations associated with the acquisition of toceranib resistance. Secondary KIT mutations (c.998G>C and c.2383G>C), which were not initially detected in tumour cells at diagnosis, were identified after the development of resistance to toceranib. This indicates that the tumour cells in feline MCTs in the same case have diverse characteristics. Our findings encourage further investigation into the development of therapeutic strategies for feline MCTs, particularly focusing on the heterogeneous nature of KIT/KIT and overcoming acquired resistance to toceranib.
Published: 2024
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215. Majocchi’s Granuloma with Epidermal Cysts due to Trichophyton rubrum: Ultrastructural Observations

Author: Naomi Tani, Nanako Yamada, Kazushi Anzawa, Takashi Mochizuki, and Osamu Yamamoto
Subjects: Granuloma trichophyticum, Majocchi’s granuloma, Trichophyton rubrum, electron microscopy, immunosuppressive patient, Dermatology, RL1-803
Abstract: Abstract is missing (Short communication)
Published: 2024
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216. Involvement of lipid-translocating exporter family proteins in determination of myriocin sensitivity in budding yeast

Author: Takahiro Kawaguchi, Yohei Ishibashi, Momoko Matsuzaki, Satomi Yamagata, and Motohiro Tani
Subjects: Sphingolipid, Myriocin, Long-chain base, Lipid-translocating exporter family, Rta1-like family, Budding yeast, Biology (General), QH301-705.5, Biochemistry, QD415-436
Abstract: Myriocin is an inhibitor of serine palmitoyltransferase involved in the initial biosynthetic step for sphingolipids, and causes potent growth inhibition in eukaryotic cells. In budding yeast, Rsb1, Rta1, Pug1, and Ylr046c are known as the Lipid-Translocating Exporter (LTE) family and believed to contribute to export of various cytotoxic lipophilic compounds. It was reported that Rsb1 is a transporter responsible for export of intracellularly accumulated long-chain bases, which alleviate the cytotoxicity. In this study, it was found that LTE family genes are involved in determination of myriocin sensitivity in yeast. Analyses of effects of deletion and overexpression of LTE family genes suggested that all LTEs contribute to suppression of cytotoxicity of myriocin. It was confirmed that RSB1 overexpression suppressed reduction in complex sphingolipid levels caused by myriocin treatment, possibly exporting myriocin to outside of the cell. These results suggested that LTE family genes function as a defense mechanism against myriocin.
Published: 2024
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217. Seed quality as a proxy of climate-ready orphan legumes: the need for a multidisciplinary and multi-actor vision

Author: Alma Balestrazzi, Cinzia Calvio, Anca Macovei, Andrea Pagano, Patrick Laux, Hassane Moutahir, Loїc Rajjou, Eleni Tani, Dimosthenis Chachalis, Christos Katsis, Lamiae Ghaouti, Said Gmouh, Sanaa Majid, Amine Elleuch, Moez Hanin, Bassem Khemakhem, Hanen El Abed, Joao Nunes, Susana Araújo, Aziz Benhamrouche, and Mohand Bersi
Subjects: climate change, Greater Mediterranean Region, resilience, food security, multi-actor approach, underutilized legumes, Plant culture, SB1-1110
Abstract: In developing countries, orphan legumes stand at the forefront in the struggle against climate change. Their high nutrient value is crucial in malnutrition and chronic diseases prevention. However, as the ‘orphan’ definition suggests, their seed systems are still underestimated and seed production is scanty. Seed priming is an effective, sustainable strategy to boost seed quality in orphan legumes for which up-to-date guidelines are required to guarantee reliable and reproducible results. How far are we along this path? What do we expect from seed priming? This brings to other relevant questions. What is the socio-economic relevance of orphan legumes in the Mediterranean Basin? How to potentiate a broader cultivation in specific regions? The case study of the BENEFIT-Med (Boosting technologies of orphan legumes towards resilient farming systems) project, developed by multidisciplinary research networks, envisions a roadmap for producing new knowledge and innovative technologies to improve seed productivity through priming, with the long-term objective of promoting sustainability and food security for/in the climate-sensitive regions. This review highlights the existing drawbacks that must be overcome before orphan legumes could reach the state of ‘climate-ready crops’. Only by the integration of knowledge in seed biology, technology and agronomy, the barrier existing between research bench and local agricultural fields may be overcome, generating high-impact technical innovations for orphan legumes. We intend to provide a powerful message to encourage future research in line with the United Nations Agenda 2030 for Sustainable Development.
Published: 2024
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218. Evidence for tWZ production in proton-proton collisions at s=13 TeV in multilepton final states

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, M.A. Shahzad, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, S. Elgammal, A. Ellithi Kamel, A. Lotfy, M.A. Mahmoud, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. 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Arcaro, C. Cosby, Z. Demiragli, C. Erice, E. Fontanesi, D. Gastler, S. Jeon, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, S. Yuan, G. Benelli, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J.M. Hogan, T. Kwon, G. Landsberg, K.T. Lau, D. Li, J. Luo, S. Mondal, M. Narain, N. Pervan, S. Sagir, F. Simpson, M. Stamenkovic, W.Y. Wong, X. Yan, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P.T. Cox, R. Erbacher, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, W. Wei, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, W.A. Nash, D. Saltzberg, B. Stone, V. Valuev, R. Clare, M. Gordon, G. Hanson, W. Si, S. Wimpenny, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, G. Collura, A. Dorsett, J. Incandela, M. Kilpatrick, A.J. Li, P. Masterson, H. Mei, M. Oshiro, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J.M. Lawhorn, J. Mao, H.B. Newman, T.Q. Nguyen, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, M.B. Andrews, P. Bryant, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, F. Marini, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, J. Monroy, J.R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, M.R. Adams, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, T.Á. Vámi, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, K. Wong, J. Bendavid, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, C. Fangmeier, F. Golf, G. Haza, J. Hossain, C. Joo, I. Kravchenko, I. Reed, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, A.G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Single top quark, Z boson, Machine learning, Multilepton, Physics, QC1-999
Abstract: The first evidence for the standard model production of a top quark in association with a W boson and a Z boson is reported. The measurement is performed in multilepton final states, where the Z boson is reconstructed via its decays to electron or muon pairs. At least one W boson, associated or from top quark decay, decays leptonically, too. The analysed data were recorded by the CMS experiment at the CERN LHC in 2016–2018 in proton-proton collisions at s=13 TeV, and correspond to an integrated luminosity of 138 fb−1. The measured cross section is 354±54(stat)±95(syst) fb, and corresponds to a statistical significance of 3.4 standard deviations.
Published: 2024
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219. Prognostic impact of increase in left atrial volume following left atrial appendage closure: Insights from the OCEAN-LAAC registry

Author: Hideaki Nonaka, Masahiko Asami, Yu Horiuchi, Jun Tanaka, Daiki Yoshiura, Kota Komiyama, Hitomi Yuzawa, Kengo Tanabe, Mitsuru Sago, Shuhei Tanaka, Ryuki Chatani, Daisuke Hachinohe, Toru Naganuma, Yohei Ohno, Tomoyuki Tani, Hideharu Okamatsu, Kazuki Mizutani, Yusuke Watanabe, Masaki Izumo, Mike Saji, Shingo Mizuno, Hiroshi Ueno, Shunsuke Kubo, Shinichi Shirai, Masaki Nakashima, Masanori Yamamoto, and Kentaro Hayashida
Subjects: Heart failure, Left atrial appendage, Left atrial appendage closure, Left atrial volume, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Background: Percutaneous left atrial appendage closure (LAAC) is an effective therapy to prevent thromboembolic events among patients with atrial fibrillation (AF). However, since the left atrial appendage (LAA) contributes to left atrial volume and serves as a buffer for increasing left atrial pressure, this procedure may impair left atrium (LA) compliance, enlarge LA, and deteriorate diastolic function. In this study, we sought to investigate the change in left atrial volume index (LAVI) following LAAC and its effect on prognosis. Methods and Results: We analyzed 225 patients from the OCEAN-LAAC registry, an ongoing, multicenter Japanese study. Comparing LAVI measurements at baseline and 6 months after LAAC, no significant increase was observed (55.0 [44.0, 70.0] ml/m2 vs. 55.0 [42.0, 75.6] ml/m2; P = 0.31). However, some patients underwent LAVI increase. Particularly, a smaller LAVI (odds ratio [OR]: 0.98 [95 % confidence interval (CI): 0.97–0.996]) and elevated tricuspid regurgitation pressure (TRPG) at baseline (OR: 1.04 [95 % CI: 1.00 – 1.08]) were significantly related to the increase in LAVI at 6-month follow-up. In addition, a 5 ml/m2 increase in LAVI was significantly associated with subsequent heart failure hospitalization (HFH) (hazard ratio: 3.37 [95 % CI: 1.18–9.65]). This association, however, was not observed in patients with lower baseline LAVI (≤55 ml/m2) but was only seen in those with a baseline LAVI over 55 ml/m2. Conclusion: Our study demonstrated an increase in LAVI after LAAC was related to smaller LAVI or elevated TRPG at baseline. The LAVI increase was significantly associated with subsequent HFH.
Published: 2024
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220. An absorption model of volatile organic compound by plant leaf: The most influential site in the absorption pathway

Author: Mizuki Yamane and Akira Tani
Subjects: Fick's first law of diffusion, Henry's law constant, Octanol-water partition coefficient, Aldehydes, Ketones, Environmental pollution, TD172-193.5, Meteorology. Climatology, QC851-999
Abstract: Plant leaves absorb some kinds of volatile organic compounds (VOCs) and can contribute to air purification, as revealed by recent exposure experiments conducted at environmentally realistic concentrations in ppb (v/v). However, the mechanisms underlying VOC absorption by plants remain unclear. In this study, we applied Fick's first law of diffusion to a VOC absorption model for plant leaves to account for the VOC diffusion process via stomata, air-liquid partitioning, partitioning into the plasma membrane, and metabolic conversion of the VOC in plant cells. The resistance and concentration of VOCs at individual sites were determined using previously reported absorption data for aliphatic aldehydes and ketones in three plant species and the leaf morphology parameters obtained from leaf cross-section micrographs. The highest resistance occurred at the metabolic site (rmet), suggesting that VOC metabolic capacity is the most influential factor in VOC absorption. The resistance of stomata (rs) or plasma membrane (rpl) was the second highest, depending on compound family. Using the absorption rate data of Q. acutissima, it is revealed that metabolic site resistance rmet for methyl vinyl ketone is affected by light intensity. Thus, our VOC absorption model can determine the most influential site in the absorption pathway both for different VOCs and plant species. Our model can contribute to the development of plant-based strategies for controlling air pollution.
Published: 2024
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221. Enhancement of signal intensity of elements in human blood serum using a metal mesh-enhanced CO2 laser-induced breakdown spectroscopy in ambient He gas

Author: Ali Khumaeni, Wahyu Setia Budi, Rinda Hedwig, Kazuyoshi Kurihara, Masahiko Tani, and Koo Hendrik Kurniawan
Subjects: Elemental analysis, Human blood serum, Laser-induced breakdown spectroscopy, LIBS, Pulse CO2 laser, Analytical chemistry, QD71-142
Abstract: Accurate and reliable identification and analysis of the elemental composition of human blood serum is of utmost importance. The present investigation included the analysis of human blood serums for elemental composition using a metal mesh-supported CO2 laser-induced breakdown spectroscopy under a helium gas environment at atmospheric pressure. In this study, a pulsed transversely excited atmospheric CO2 laser with a wavelength of 10.64 µm and a pulse duration of 200 ns was applied to irradiate the human blood serum film placed on a copper metal to induce a luminous plasma. A significant increment of elemental signal intensity occurs by introducing a metal mesh covering the serum film. Qualitative and quantitative analyses have been conducted on the human blood serum's major, minor, and trace elements. The concentrations of elements in the human blood are estimated to be 9160 parts per million (ppm) for carbon (C), 174 ppm for calcium (Ca), 600 ppm for potassium (K), 1410 ppm for magnesium (Mg), 343 ppm for phosphorus (P), 2180 ppm for sodium (Na), and 48 ppm for iron (Fe). The results of the CO2 LIBS method demonstrate a high level of concurrence with the results obtained by the conventional XRF method.
Published: 2024
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222. Han desaparecido los estigmas? Prácticas y representaciones sociales del 'loco' y de la 'locura' entre expertos brasileños y expertos en formación en un contexto de cambios institucionales en Brasil.

Author: Annamaria Silvana de ROSA, Elena BOCCI, and Tani PEDREIRA
Subjects: Medicine, Public aspects of medicine, RA1-1270
Abstract: O artigo reconstrui sinteticamente os principais passos da reforma psiquiátrica no Brasil, assim como as medidas que favoreceram a transição gradual, não sem dificuldades, das instituições totais para os Centros de Atenção Psicossocial - CAPS. As transformações produzidas pela reforma psiquiátrica no Brasil no contexto mais amplo dos processos antimaniconiais de vários movimentos ao redor do mundo têm sido amplamente documentadas na literatura. Vários autores, inclusive brasileiros, inspirados na Teoria das Representações Sociais, têm destacado nos resultados obtidos por pesquisa, as relações entre as práticas e representações sociais. O estudo ora apresentado faz parte de um programa de investigação muito maior, hoje estendido para contexto cultural brasileiro, conduzido por de Rosa na década de 80, tendo sido objeto de recente acompanhamento 30 anos depois da reforma psiquiátrica na Itália. A discussão dos resultados, produto de uma seleção de especialistas e de especialistas em treinamento brasileiros tem suporte em uma relação dialógica-circular entre representações sociais e práticas utilizando uma abordagem de modelagem multi método. Da mesma forma que observado no estudo realizado amplamente na Itália e em outros países europeus, os resultados da pesquisa no Brasil enfatizam a aparente contradição entre as representações evoluídas da discriminação par e passo com as intenções comportamentais e as práticas orientadas pela tolerância anti-estigma detectadas por instrumentos de estrutura verbal além da persistência de núcleos estereotipados com relação à loucura e ao doente mental, identificadas por técnicas projetivas gráficas e figurativas. Os resultados também fornecem uma verificação ulterior empírica do conceito de “polifásia cognitiva”1 que revelam a coexistência de representações arcaicas e modernas, míticas e científicas, vinculadas ao senso comum ou ao conhecimento especializado dirigido ao grande público.
Published: 2012
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223. Consistency of antenatal contraceptive plan and postpartum fulfillment in patients with opioid use disorder

Author: Malhotra, Tani, Thomas, Kathryn, Ngendahimana, David, Gibson, Kelly S, and Arora, Kavita Shah
Published: 2024
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224. Hot QCD White Paper

Author: Arslandok, M, Bass, SA, Baty, AA, Bautista, I, Beattie, C, Becattini, F, Bellwied, R, Berdnikov, Y, Berdnikov, A, Bielcik, J, Blair, JT, Bock, F, Boimska, B, Bossi, H, Caines, H, Chen, Y, Chien, Y-T, Chiu, M, Connors, ME, Csanád, M, Silva, CL da, Dash, AP, David, G, Dehmelt, K, Dexheimer, V, Dong, X, Drees, A, Du, L, Durham, JM, Ehlers, RJ, Elfner, H, Evdokimov, O, Finger, M, Jr, M Finger, Frantz, J, Frawley, AD, Gale, C, Geurts, F, Gonzalez, V, Grau, N, Greene, SV, Grossberndt, SK, Hachiya, T, He, X, Heinz, U, Hong, B, Humanic, TJ, Ivanishchev, D, Jacak, BV, Jahan, J, Jeon, S, Jheng, HR, Jia, J, Judd, EG, Kapusta, JI, Karpenko, I, Khachatryan, V, Kharzeev, DE, Kim, M, Kimelman, B, Klay, JL, Klein, SR, Knospe, AG, Koch, V, Kotov, D, Krintiras, GK, Elayavalli, R Kunnawalkam, Kuo, CM, Lajoie, JG, Lee, Y-J, Li, W, Liao, J, Likmeta, I, Lim, SH, Liu, MX, Loizides, C, Longo, R, Luo, X, Luzum, M, Ma, R, Majumder, A, Mak, S, Markert, C, Mehtar-Tani, Y, Mignerey, AC, Minafra, N, Morrison, DP, Mueller, B, Nagle, JL, Narde, A, Nattrass, CE, Niida, T, Noronha, J, Noronha-Hostler, J, Nouicer, R, Novitzky, N, O'Brien, E, Odyniec, G, Okorokov, VA, and Osborn, JD
Subjects: nucl-ex, hep-ex, hep-ph, nucl-th
Abstract: Hot QCD physics studies the nuclear strong force under extreme temperatureand densities. Experimentally these conditions are achieved via high-energycollisions of heavy ions at the Relativistic Heavy Ion Collider (RHIC) and theLarge Hadron Collider (LHC). In the past decade, a unique and substantial suiteof data was collected at RHIC and the LHC, probing hydrodynamics at the nucleonscale, the temperature dependence of the transport properties of quark-gluonplasma, the phase diagram of nuclear matter, the interaction of quarks andgluons at different scales and much more. This document, as part of the 2023nuclear science long range planning process, was written to review the progressin hot QCD since the 2015 Long Range Plan for Nuclear Science, as well ashighlight the realization of previous recommendations, and presentopportunities for the next decade, building on the accomplishments andinvestments made in theoretical developments and the construction of newdetectors. Furthermore, this document provides additional context to supportthe recommendations voted on at the Joint Hot and Cold QCD Town Hall Meeting,which are reported in a separate document.
Published: 2023

225. Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE.

Author: Iwagawa, Toshiro, Masumoto, Hiroki, Tabuchi, Hitoshi, Tani, Kenzaburo, Watanabe, Sumiko, and Conklin, Bruce
Subjects: CHM, CRISPR/Cas9, RPE, choroideremia, exon-skipping, hiPSC, Humans, Artificial Intelligence, Choroideremia, CRISPR-Cas Systems, Exons, Induced Pluripotent Stem Cells, Retinal Pigment Epithelium
Abstract: BACKGROUND: Exon-skipping is a powerful genetic tool, especially when delivering genes using an AAV-mediated full-length gene supplementation strategy is difficult owing to large length of genes. Here, we used engineered human induced pluripotent stem cells and artificial intelligence to evaluate clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9-based exon-skipping vectors targeting genes of the retinal pigment epithelium (RPE). The model system was choroideremia; this is an X-linked inherited retinal disease caused by mutation of the CHM gene. METHODS: We explored whether artificial intelligence detected differentiation of human OTX2, PAX6 and MITF (hOPM) cells, in which OTX2, PAX6 and MITF expression was induced by doxycycline treatment, into RPE. Plasmid encoding CHM exon-skipping modules targeting the splice donor sites of exons 6 were constructed. A clonal hOPM cell line with a frameshift mutation in exon 6 was generated and differentiated into RPE. CHM exon 6-skipping was induced, and the effects of skipping on phagocytic activity, cell death and prenylation of Rab small GTPase (RAB) were evaluated using flow cytometry, an in vitro prenylation assay and western blotting. RESULTS: Artificial intelligence-based evaluation of RPE differentiation was successful. Retinal pigment epithelium cells with a frameshift mutation in exon 6 showed increased cell death, reduced phagocytic activity and increased cytosolic unprenylated RABs only when oxidative stress was in play. The latter two phenotypes were partially rescued by exon 6-skipping of CHM. CONCLUSIONS: CHM exon 6-skipping contributed to RPE phagocytosis probably by increasing RAB38 prenylation under oxidative stress.
Published: 2023

226. Jet thermalization in QCD kinetic theory

Author: Mehtar-Tani, Y., Schlichting, S., and Soudi, I.
Subjects: High Energy Physics - Phenomenology
Abstract: We perform numerical studies in QCD kinetic theory to investigate the energy and angular profiles of a high energy parton - as a proxy for a jet produced heavy ion collisions - passing through a Quark-Gluon Plasma (QGP). We find that the fast parton loses energy to the plasma mainly via a radiative turbulent gluon cascade that transport energy locally from the jet down to the temperature scale where dissipation takes place. In this first stage, the angular structure of the turbulent cascade is found to be relatively collimated. However, when the lost energy reaches the plasma temperature is it rapidly transported to large angles w.r.t. the jet axis and thermalizes. We investigate the contribution of the soft jet constituents to the total jet energy. We show that for jet opening angles of about 0.3 rad or smaller the effect is negligible. Conversely, larger opening angles become more and more sensitive to the thermal component of the jet and thus to medium response. Our result showcase the importance of the jet cone size in mitigating or enhancing the details of dissipation in jet quenching observables., Comment: 41 pages, 12 figures
Published: 2022
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227. Transverse momentum broadening from NLL BFKL to all orders in pQCD

Author: Caucal, Paul and Mehtar-Tani, Yacine
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Theory, Nuclear Theory
Abstract: We study, to all orders in perturbative QCD, the universal behavior of the saturation momentum $Q_s(L)$ controlling the transverse momentum distribution of a fast parton propagating through a dense QCD medium with large size $L$. Due to the double logarithmic nature of the quantum evolution of the saturation momentum, its large $L$ asymptotics is obtained by slightly departing from the double logarithmic limit of either next-to-leading log (NLL) BFKL or leading order DGLAP evolution equations. At fixed coupling, or in conformal $\mathcal{N}=4$ SYM theory, we derive the large $L$ expansion of $Q_s(L)$ up to order $\alpha_s^{3/2}$. In QCD with massless quarks, where conformal symmetry is broken by the running of the strong coupling constant, the one-loop QCD $\beta$-function fully accounts for the universal terms in the $Q_s(L)$ expansion. Therefore, the universal coefficients of this series are known exactly to all orders in $\alpha_s$., Comment: 13 pages, 4 figures, 3 appendices
Published: 2022
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228. A regionalized partially nonergodic ground-motion data driven model for low to moderate seismicity areas: using RESIF-RAP, ESM, RESORCE and NGA-West2 data

Author: Chaibeddra Tani, Fayçal and Derras, Boumédiène
Published: 2024
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229. Safety and Efficacy of Lenvatinib in Very Old Patients with Unresectable Hepatocellular Carcinoma

Author: Camera, Silvia, Rimini, Margherita, Rossari, Federico, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Yoo, Changhoon, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Presa, José, Masi, Gianluca, Bergamo, Francesca, Salani, Francesca, Marseglia, Mariarosaria, Amadeo, Elisabeth, Vitiello, Francesco, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Iavarone, Massimo, Cabibbo, Giuseppe, Montes, Margarida, Foschi, Francesco Giuseppe, Vivaldi, Caterina, Lonardi, Sara, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Hiraoka, Atsushi, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Persano, Mara, Foti, Silvia, Piscaglia, Fabio, Scartozzi, Mario, Cascinu, Stefano, and Casadei-Gardini, Andrea
Published: 2024
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230. Mountain masses as a determinant to genetic structure of char distributed in the Chugoku region, Japan

Author: Kawai, Koichiro, Matsuo, Mahiro, Fujiwara, Kazuki, Tani, Shotaro, Tada, Shohei, and Saito, Hidetoshi
Published: 2024
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231. Effect of periodontitis induced by Fusobacterium nucleatum on the microbiota of the gut and surrounding organs

Author: Lee, Sangmin, Haraga, Hiroshi, Satoh, Takenori, Mutoh, Noriko, Watanabe, Kiyoko, Hamada, Nobushiro, and Tani-Ishii, Nobuyuki
Published: 2024
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232. Predictors of technical difficulty for trainees in esophageal endoscopic submucosal dissection

Author: Ueda, Tomoya, Ishihara, Ryu, Yoshii, Shunsuke, Li, James Weiquan, Asada, Yuya, Kitagawa, Daiki, Kizawa, Atsuko, Ninomiya, Takehiro, Okubo, Yuki, Kawakami, Yushi, Tani, Yasuhiro, Shichijo, Satoki, Kanesaka, Takashi, Yamamoto, Sachiko, Takeuchi, Yoji, Higashino, Koji, Uedo, Noriya, and Michida, Tomoki
Published: 2024
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233. Cotton Based Self-Powered Temperature Sensor Based on Au-Augmented WS2 Triboelectric Nanogenerator

Author: Chekke, Tani, Narzary, Ringshar, Ngadong, Soni, Satpati, Biswarup, Bayan, Sayan, and Das, Upamanyu
Published: 2024
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234. How a “Something Else” Response Option for Sexual Identity Affects National Survey Estimates of Associations Between Sexual Identity, Reproductive Health, and Substance Use

Author: West, Brady T., Engstrom, Curtiss W., Schepis, Ty S., Tani, Ilmul J., and McCabe, Sean Esteban
Published: 2024
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235. Clinical application of 18F-fluorodeoxyglucose positron emission tomography/computed tomography radiomics-based machine learning analyses in the field of oncology

Author: Nakajo, Masatoyo, Jinguji, Megumi, Ito, Soichiro, Tani, Atushi, Hirahara, Mitsuho, and Yoshiura, Takashi
Published: 2024
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236. Successful School Interventions for Students with Disability during COVID-19: Empirical Evidence from Australia

Author: Smith, Catherine, Tani, Massimiliano, Yates, Sophie, and Dickinson, Helen
Abstract: Children and young people with disability are a "vulnerable" population within a pandemic context as they face structural inequities and discrimination as a result of their impairments. In this paper, we report research that sought to examine the learning experiences of children and young people with disability during the COVID-19 pandemic. We wanted to understand how this group fared and whether different interventions impacted on these experiences. Data were collected from an online survey organized by Children and Young People with Disability Australia (CYDA) that garnered responses from more than 700 families. The study contributes empirical evidence to the growing literature about COVID-19-related impacts on learners already recognized as experiencing multiple disadvantages in schooling. We find some significant gaps in supports offered to students with disability and their families. Notwithstanding that some students did not receive any support from their schools, where supports were offered, social supports had the greatest positive impact on feelings of learner engagement. Our findings support key propositions in the social and emotional learning literature, namely that particular resourcing should be dedicated to social interaction and feelings of belonging as these are crucial to learners engaging in learning processes. There are clear implications of these findings in terms of what educational institutions might do to help engage students with disability in remote learning.
Published: 2023
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237. A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921

Author: Tahara, Arisu, Tani, Kazuki, Wakatsuki, Miyu, Tokiwa, Toshiyuki, Higo, Mayuka, Nonaka, Kenichi, Hirose, Tomoyasu, Hokari, Rei, Ishiyama, Aki, Iwatsuki, Masato, Watanabe, Yoshihiro, Honsho, Masako, Asami, Yukihiro, Matsui, Hidehito, Sunazuka, Toshiaki, Hanaki, Hideaki, Teruya, Toshiaki, and Ishii, Takahiro
Published: 2023
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238. Airborne hydrophilic microplastics in cloud water at high altitudes and their role in cloud formation

Author: Wang, Yize, Okochi, Hiroshi, Tani, Yuto, Hayami, Hiroshi, Minami, Yukiya, Katsumi, Naoya, Takeuchi, Masaki, Sorimachi, Atsuyuki, Fujii, Yusuke, Kajino, Mizuo, Adachi, Kouji, Ishihara, Yasuhiro, Iwamoto, Yoko, and Niida, Yasuhiro
Published: 2023
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239. Associations Between Drug Treatments and the Risk of Aneurysmal Subarachnoid Hemorrhage: a Systematic Review and Meta-analysis

Author: Shimizu, Kampei, Aoki, Tomohiro, Etminan, Nima, Hackenberg, Katharina A. M., Tani, Shoichi, Imamura, Hirotoshi, Kataoka, Hiroharu, and Sakai, Nobuyuki
Published: 2023
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240. Detection of bone marrow edema in differential diagnoses of odontogenic cysts using dual-energy computed tomography

Author: Hasegawa, Takumi, Arimoto, Satomi, Saito, Izumi, Yatagai, Nanae, Murakami, Aki, Sasaki, Aki, Tadokoro, Yoshiaki, Tani, Wakiko, Kagawa, Kiyosumi, and Akashi, Masaya
Published: 2023
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241. Clinical significance of KL-6 in immune-checkpoint inhibitor treatment for non-small cell lung cancer

Author: Nakahama, Kenji, Izumi, Motohiro, Yoshimoto, Naoki, Fukui, Mitsuru, Sugimoto, Akira, Nagamine, Hiroaki, Ogawa, Koichi, Sawa, Kenji, Tani, Yoko, Kaneda, Hiroyasu, Mitsuoka, Shigeki, Watanabe, Tetsuya, Asai, Kazuhisa, and Kawaguchi, Tomoya
Published: 2023
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242. Efficacy and safety of atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma patients with esophageal–gastric varices

Author: Tada, Fujimasa, Hiraoka, Atsushi, Tada, Toshifumi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Naganuma, Atsushi, Kosaka, Hisashi, Matono, Tomomitsu, Kuroda, Hidekatsu, Yata, Yutaka, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Yokohama, Keisuke, Nishikawa, Hiroki, Imai, Michitaka, Koizumi, Yohei, Nakamura, Shinichiro, Iijima, Hiroko, Kaibori, Masaki, Hiasa, Yoichi, and Kumada, Takashi
Published: 2023
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243. Refugees as Skilled Migrants: Insights from Australia’s 2018 Employer-Sponsored Refugee Migration Pilot

Author: Higgins, Claire, Baker, Sally, Cousins, Stephanie, Wang, Ben Zhe, Cheng, Zhiming, Tani, Massimiliano, and Jack, Victoria
Published: 2023
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244. Does Certifying Foreign Qualifications Lead to Better Immigrant Skills Utilization?

Author: Pecoraro, Marco and Tani, Massimiliano
Published: 2023
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245. Evaluating prognostic significance of preoperative C-reactive protein to albumin ratio in older patients with pathological stage II or III colorectal cancer

Author: Koji Numata, Yukari Ono, Mihwa Ju, Shizune Onuma, Ayano Tanaka, Taichi Kawabe, Sho Sawazaki, Akio Higuchi, Kazuki Yamanaka, Shinsuke Hatori, Hiroyuki Saeki, Hiroshi Matsukawa, Yasushi Rino, and Kazuyuki Tani
Subjects: colorectal neoplasms, curative surgery, older patients, c-reactive protein to albumin ratio, prognosis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Purpose This study was performed to evaluate the prognostic value of preoperative C-reactive protein to albumin ratio (CAR) in older patients with colorectal cancer (CRC) undergoing curative resection. Methods We retrospectively analyzed 244 older patients (aged 75 years or higher) with pathological stage II or III CRC who underwent curative surgery between 2008 and 2016. The optimal value of CAR was calculated and its correlation with the clinicopathological factors and prognosis was examined. Results The optimal cutoff value of the CAR was 0.085. High preoperative CAR was significantly associated with high carcinoembryonic antigen levels (P=0.001), larger tumor size (P
Published: 2024
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246. Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions

Author: Saori Yoshimura, Ryuki Shimada, Koji Kikuchi, Soichiro Kawagoe, Hironori Abe, Sakie Iisaka, Sayoko Fujimura, Kei-ichiro Yasunaga, Shingo Usuki, Naoki Tani, Takashi Ohba, Eiji Kondoh, Tomohide Saio, Kimi Araki, and Kei-ichiro Ishiguro
Subjects: Science
Abstract: Abstract Meiotic prophase progression is differently regulated in males and females. In males, pachytene transition during meiotic prophase is accompanied by robust alteration in gene expression. However, how gene expression is regulated differently to ensure meiotic prophase completion in males remains elusive. Herein, we identify HSF5 as a male germ cell-specific heat shock transcription factor (HSF) for meiotic prophase progression. Genetic analyzes and single-cell RNA-sequencing demonstrate that HSF5 is essential for progression beyond the pachytene stage under non-stress conditions rather than heat stress. Chromatin binding analysis in vivo and DNA-binding assays in vitro suggest that HSF5 binds to promoters in a subset of genes associated with chromatin organization. HSF5 recognizes a DNA motif different from typical heat shock elements recognized by other canonical HSFs. This study suggests that HSF5 is an atypical HSF that is required for the gene expression program for pachytene transition during meiotic prophase in males.
Published: 2024
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247. A digital twin prototype to visualize heterogeneous seismic damage simulation results on web-GIS

Author: Takuzo Yamashita, Yoshihide Sekimoto, Mikio Koshihara, Takafumi Nakagawa, Hideyuki O-Tani, and Toshihiko Horiuchi
Subjects: digital twin, seismic response analysis, geographic information system, visualization, resilience, Architecture, NA1-9428, Building construction, TH1-9745
Abstract: Access to a wide range of information tailored to specific purposes, including extensive damage projections and statistics for target areas and the potential for individual building and dwelling damage predicted through simulations, enhances cities’ resilience against large-scale earthquakes. Recognizing the significance of this, we have developed a prototype of a digital twin capable of comprehensively visualizing various simulations on a web-based geographic information system (GIS) platform. This prototype employs three seismic damage simulators: the Integrated Earthquake Simulation for area damage, the wallstat for wooden houses, and the E-Simulator for a reinforced concrete building. A trial of earthquake damage simulations was conducted to assess this prototype’s efficacy, focusing on the damage incurred in Mashiki Town during the 2016 Kumamoto earthquake. The trial successfully verified the capability of the system to visualize and integrate various types of simulation data alongside records obtained from actual earthquake disasters. This paper provides an overview of the digital twin prototype. It reports on the trial’s results, focusing on the visualization and integration achieved through this trial.
Published: 2024
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248. Formations of force network and softening of amorphous elastic materials from a coarsen-grained particle model

Author: Rei Kurita, Yuto Tamura, and Marie Tani
Subjects: Amorphous materials, Coarsen-grain particle model, Force networks, Softening, Medicine, Science
Abstract: Abstract Amorphous materials, such as granular substances, glasses, emulsions, foams, and cells, play significant roles in various aspects of daily life, serving as building materials, plastics, food products, and agricultural items. Understanding the mechanical response of these materials to external forces is crucial for comprehending their deformation, toughness, and stiffness. Despite the recognition of the formation of force networks within amorphous materials, the mechanisms behind their formation and their impact on macroscopic physical properties remain elusive. In this study, we employ a coarse-grained particle model to investigate the mechanical response, wherein local physical properties are integrated into the softness of the particles. Our findings reveal the emergence of a chain-like force distribution, which correlates with the planar distribution of softness and heterogeneous density variations. Additionally, we observe that the amorphous material undergoes softening due to the heterogeneous distribution of softness, a phenomenon explicable through a simple theoretical framework. Moreover, we demonstrate that the ambiguity regarding the size ratio of the blob to the force network can be adjusted by the amplitude of planar fluctuations in softness, underscoring the robustness of the coarse-grained particle model.
Published: 2024
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249. Management of hepatocellular carcinoma, an important cause of death in Japanese autoimmune hepatitis patients

Author: Tomoko Tadokoro, Takako Nomura, Koji Fujita, Takushi Manabe, Kei Takuma, Mai Nakahara, Kyoko Oura, Shima Mimura, Joji Tani, Asahiro Morishita, Hideki Kobara, Masafumi Ono, and Tsutomu Masaki
Subjects: Autoimmune hepatitis, Hepatocellular carcinoma, Molecular-targeted drug, Immune checkpoint inhibitor, Carcinogenic factor, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Abstract Background Hepatocellular carcinoma (HCC) in autoimmune hepatitis (AIH) was considered rare but is increasing with prolonged prognosis. Its impact on the overall prognosis of AIH is unknown, and treatment has not been established. Aim To investigate the risk factors and prognosis of HCC in patients with AIH and identify appropriate management strategies. Methods We studied patients with AIH including background liver disease, sex, age, complications, treatment, response to treatment, liver fibrosis, prognosis, and treatment. Results In 131 patients, deaths due to liver failure were more common early after the onset of AIH; however, deaths due to HCC increased gradually. HCC was observed in 12 patients (median age, 70 years; male/female, 4/8; cirrhosis at onset, 11; median time to carcinogenesis, 7 years). Cirrhosis at diagnosis was identified as a risk factor for carcinogenesis in the multivariate analysis (odds ratio, 41.36; p
Published: 2024
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250. Establishment of immortalized Egyptian Rousettus bat cell lines

Author: Lanlan Bai, Tetsuya Tani, Takeshi Kobayashi, Ryotaro Nouda, Yuta Kanai, Yusuke Sano, Kazutoshi Takami, Hiroshi Tomita, Eriko Sugano, Taku Ozaki, Tohru Kiyono, and Tomokazu Fukuda
Subjects: cell cycle regulator, Egyptian Rousettus bat, immortalized cells, SV40 large T antigen, TERT, Biology (General), QH301-705.5
Abstract: The Egyptian Rousettus bat (Rousettus aegyptiacus) is a common fruit bat species that is distributed mainly in Africa and the Middle East. Bats serve as reservoir hosts for numerous pathogens. Human activities, such as hunting bats for food, managing vermin, and causing habitat loss, elevate the likelihood of transmission of bat pathogens to humans and other animals. Consequently, bat cell lines play a crucial role as research materials for investigating viral pathogens. However, the inherent limitation of finite cell division in primary cells necessitates the use of immortalized cells derived from various bat tissues. Herein, we successfully established six fibroblast cell lines derived from an infant bat heart and lungs and an elderly bat heart. Three of the six cell lines, called K4DT cells, were transduced by a combination of cell cycle regulators, mutant cyclin‐dependent kinase 4, cyclin D1, and human telomerase reverse transcriptase. The other three cell lines, named SV40 cells, were transfected with simian virus 40 large T antigen. Transgene protein expression was detected in the transduced cells. All three K4DT cell lines and one lung‐derived SV40 cell line were virtually immortalized and nearly maintained the normal diploid karyotypes. However, the two other heart‐derived SV40 cell lines had aberrant karyotypes and the young bat‐derived cell line stopped proliferating at approximately 40 population doublings. These bat cell lines are valuable for studying pathogen genomics and biology.
Published: 2024
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