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224. McLeod Syndrome: A Perspective from Japanese Blood Centers.

Author

Walker, Ruth H., Saiki, Shinji, Danek, Adrian, Tani, Y., Takahashi, J., Tanaka, M., and Shibata, H.

Abstract

McLeod phenotype is one of the rare blood cell types, defined as those that occur at a frequency of 1:1,000 or less. We have screened donors for rare cells since 1987 using mouse monoclonal antibodies (MAbs). In the western regions of Japan a total of 16,160,714 donor red cells were screened using mouse anti-Kell MAbs (anti-k, anti-Ku and anti-K14) during 1987-2005. We found 182 blood cells with McLeod phenotype or Kmod and 286 with Ko. To identify McLeod phenotype, we examine the expression level of Kell antigens by flow cytometry, cell morphology (acanthocytes) by scanning electron microscopy, red cells of family members and the XK gene. As a result, we identified three donors with McLeod phenotype (two subsequently developed McLeod syndrome) and two with McLeod-like phenotype. Nine donors are now registered as McLeod phenotype in all Japan. [ABSTRACT FROM AUTHOR]

Published
2008
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234. Evaluation of a blood group genotyping platform ( BLOODchip® Reference) in Japanese samples.

Author

Tanaka, M., Kamada, I., Takahashi, J., Hirayama, F., and Tani, Y.

Subjects
BLOOD grouping & crossmatching, GENOTYPE-environment interaction, PHENOTYPES, BLOOD sampling, GENETIC polymorphisms
Abstract

SUMMARY Background Blood-group genotyping arrays have been widely used in Caucasian and African American populations, but have not been thoroughly tested in Japanese subjects. Aim To evaluate, using the BLOODchip® Reference genotyping system, the concordance of previously typed samples with expected phenotypes and the coverage of the Japanese variants. Methods Blood samples from 100 Japanese donors were obtained. DNA was extracted with QIAsymphony (Qiagen, Hilden, Germany). Samples were typed by serological methods and processed with the BLOODchip®. When a non-concordant result was identified, further sequencing by polymerase chain reaction-single specific primer ( PCR-SSP) was performed. Results Concordance between systems was 98% (736/751), and 98.8% (742/751) if only non-software-related non-concordances were considered. In the ABO group, 6 'No Call' ( NC, inability of the BLOODchip® to assign a result) were ascribed to a variant of blood subtype A1 ( A102; 467C>T), a common subtype in Asian populations, whereas three NC presented additional polymorphisms not contained in the BLOODchip® ( A102/ A205, A102/ O06 and A204/ O02). In the RhD group, one discrepancy was correctly genotyped as RHD* 1227A (Del phenotype) by the BLOODchip® (phenotyped as partial D, RHD* DIVb). Another was phenotyped as D+ by the BLOODchip® (phenotyped weak D by serology) and confirmed as RHD*D- CE(2)-D heterozygous by sequencing. The 3 RhD NC can be solved by further software update. For RhCE, one discrepancy was correctly genotyped for both systems; however, only the BLOODchip® was able to detect RHCE* CX allele. Conclusions By programming the A102 ABO variant into the system software with the new allele combinations, the BLOODchip® Reference is a suitable genotyping tool to be applied to Asian samples. [ABSTRACT FROM AUTHOR]

Published
2014
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239. Terminology for Red Cell Surface Antigens

Author

Daniels, G.L., primary, Anstee, D.J., additional, Cartron, J.P., additional, Dahr, W., additional, Garratty, G., additional, Henry, S., additional, Jorgensen, J., additional, Judd, W.J., additional, Kornstad, L., additional, Levene, C., additional, Lomas‐Francis, C., additional, Lubenko, A., additional, Moulds, J.J., additional, Moulds, J.M., additional, Moulds, M., additional, Overbeeke, M., additional, Reid, M.E., additional, Rouger, P., additional, Scott, M., additional, Seidl, S., additional, Sistonen, P., additional, Tani, Y., additional, Wendel, S., additional, and Zelinski, T., additional

Published
1999
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