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1,698 results on '"Tang, W.H. Wilson"'

202. Validating an Idiopathic Dilated Cardiomyopathy Diagnosis Using Cardiovascular Magnetic Resonance: The Dilated Cardiomyopathy Precision Medicine Study

Author

Haas, Garrie J., primary, Zareba, Karolina M., additional, Ni, Hanyu, additional, Bello-Pardo, Erika, additional, Huggins, Gordon S., additional, Hershberger, Ray E., additional, Kinnamon, Daniel D., additional, Jordan, Elizabeth, additional, Haas, Garrie J., additional, Fishbein, Daniel P., additional, Gottlieb, Stephen S., additional, Wheeler, Matthew T., additional, Hofmeyer, Mark, additional, Tang, W.H. Wilson, additional, Owens, Anjali T., additional, Moore, Charles K., additional, Jimenez, Javier, additional, Trachtenberg, Barry H., additional, Sweitzer, Nancy K., additional, Shah, Palak, additional, Lowes, Brian D., additional, Stoller, Douglas, additional, Smart, Frank, additional, Morris, Alanna A., additional, Wilcox, Jane E., additional, Katz, Stuart, additional, Pan, Stephen, additional, Ewald, Gregory A., additional, Aaronson, Keith D., additional, Wang, Jessica J., additional, Pamboukian, Salpy, additional, Judge, Daniel P., additional, Kransdorf, Evan P., additional, Garg, Sonia, additional, Desvigne-Nickens, Patrice, additional, Troendle, James, additional, Fu, Yi-Ping, additional, and Hindorff, Lucia, additional

Published
2022
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203. 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Author

Yancy, Clyde W., Jessup, Mariell, Bozkurt, Biykem, Butler, Javed, Casey, Donald E., Jr., Drazner, Mark H., Fonarow, Gregg C., Geraci, Stephen A., Horwich, Tamara, Januzzi, James L., Johnson, Maryl R., Kasper, Edward K., Levy, Wayne C., Masoudi, Frederick A., McBride, Patrick E., McMurray, John J.V., Mitchell, Judith E., Peterson, Pamela N., Riegel, Barbara, Sam, Flora, Stevenson, Lynne W., Tang, W.H. Wilson, Tsai, Emily J., and Wilkoff, Bruce L.

Published
2013
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215. Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis

Author

Schillemans, Tessa, Tragante, Vinicius, Maitusong, Buamina, Gigante, Bruna, Cresci, Sharon, Laguzzi, Federica, Vikström, Max, Richards, Mark, Pilbrow, Anna, Cameron, Vicky, Foco, Luisa, Doughty, Robert N., Kuukasjärvi, Pekka, Allayee, Hooman, Hartiala, Jaana A., Tang, W.H. Wilson, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Laurikka, Jari O., Srinivasan, Sundararajan, Mordi, Ify R., Trompet, Stella, Kraaijeveld, Adriaan, van Setten, Jessica, Gijsberts, Crystel M., Maitland-van der Zee, Anke H., Saely, Christoph H., Gong, Yan, Johnson, Julie A., Cooper-DeHoff, Rhonda M., Pepine, Carl J., Casu, Gavino, Leiherer, Andreas, Drexel, Heinz, Horne, Benjamin D., van der Laan, Sander W., Marziliano, Nicola, Hazen, Stanley L., Sinisalo, Juha, Kähönen, Mika, Lehtimäki, Terho, Lang, Chim C., Burkhardt, Ralph, Scholz, Markus, Jukema, J. Wouter, Eriksson, Niclas, Akerblom, Axel, James, Stefan, Held, Claes, Hagström, Emil, Spertus, John A., Algra, Ale, de Faire, Ulf, Akesson, Agneta, Asselbergs, Folkert W., Patel, Riyaz S., Leander, Karin, Schillemans, Tessa, Tragante, Vinicius, Maitusong, Buamina, Gigante, Bruna, Cresci, Sharon, Laguzzi, Federica, Vikström, Max, Richards, Mark, Pilbrow, Anna, Cameron, Vicky, Foco, Luisa, Doughty, Robert N., Kuukasjärvi, Pekka, Allayee, Hooman, Hartiala, Jaana A., Tang, W.H. Wilson, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Laurikka, Jari O., Srinivasan, Sundararajan, Mordi, Ify R., Trompet, Stella, Kraaijeveld, Adriaan, van Setten, Jessica, Gijsberts, Crystel M., Maitland-van der Zee, Anke H., Saely, Christoph H., Gong, Yan, Johnson, Julie A., Cooper-DeHoff, Rhonda M., Pepine, Carl J., Casu, Gavino, Leiherer, Andreas, Drexel, Heinz, Horne, Benjamin D., van der Laan, Sander W., Marziliano, Nicola, Hazen, Stanley L., Sinisalo, Juha, Kähönen, Mika, Lehtimäki, Terho, Lang, Chim C., Burkhardt, Ralph, Scholz, Markus, Jukema, J. Wouter, Eriksson, Niclas, Akerblom, Axel, James, Stefan, Held, Claes, Hagström, Emil, Spertus, John A., Algra, Ale, de Faire, Ulf, Akesson, Agneta, Asselbergs, Folkert W., Patel, Riyaz S., and Leander, Karin

Abstract

Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator–activated receptor gamma coactivator-1 alpha (PPARGC1A), a transcription factor linked to energy metabolism which may play a role in the heart function. Thus, its associations with subsequent CHD events remain unclear. We aimed to investigate the effect of three different SNPs in the PPARGC1A gene on the risk of subsequent CHD in a population with established CHD. Methods: We employed an individual-level meta-analysis using 23 studies from the GENetIcs of sUbSequent Coronary Heart Disease (GENIUS-CHD) consortium, which included participants (n = 80,900) with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. Three variants in the PPARGC1A gene (rs8192678, G482S; rs7672915, intron 2; and rs3755863, T528T) were tested for their associations with subsequent events during the follow-up using a Cox proportional hazards model adjusted for age and sex. The primary outcome was subsequent CHD death or myocardial infarction (CHD death/myocardial infarction). Stratified analyses of the participant or study characteristics as well as additional analyses for secondary outcomes of specific cardiovascular disease diagnoses and all-cause death were also performed. Results: Meta-analysis revealed no significant association between any of the three variants in the PPARGC1A gene and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline: rs8192678, hazard ratio (HR): 1.01, 95% confidence interval (CI) 0.98–1.05 and rs7672915, HR: 0.97, 95% CI 0.94–1.00; rs3755863, HR: 1.02, 95% CI 0.99–1.06. Similarly, no significant associations were observed for any of the secondary outcomes. The results from stratified analyses showed null results, except for significant inverse associations between rs7672915 (intro

Published
2022

216. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics

Author

Hemnes, Anna R., Beck, Gerald J., Newman, John H., Abidov, Aiden, Aldred, Micheala A., Barnard, John, Berman Rosenzweig, Erika, Borlaug, Barry A., Chung, Wendy K., Comhair, Suzy A.A., Erzurum, Serpil C., Frantz, Robert P., Gray, Michael P., Grunig, Gabriele, Hassoun, Paul M., Hill, Nicholas S., Horn, Evelyn M., Hu, Bo, Lempel, Jason K., Maron, Bradley A., Mathai, Stephen C., Olman, Mitchell A., Rischard, Franz P., Systrom, David M., Tang, W.H. Wilson, Waxman, Aaron B., Xiao, Lei, Yuan, Jason X.-J., and Leopold, Jane A.

Published
2017
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217. Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions

Author

Raizada, Mohan K., Joe, Bina, Bryan, Nathan S., Chang, Eugene B., Dewhirst, Floyd E., Borisy, Gary G., Galis, Zorina S., Henderson, Wendy, Jose, Pedro A., Ketchum, Christian J., Lampe, Johanna W., Pepine, Carl J., Pluznick, Jennifer L., Raj, Dominic, Seals, Douglas R., Gioscia-Ryan, Rachel A., Tang, W.H. Wilson, and Oh, Young S.

Published
2017
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223. Effectiveness of the Family Heart Talk Communication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial.

Author

Kinnamon, Daniel D., Jordan, Elizabeth, Haas, Garrie J., Hofmeyer, Mark, Kransdorf, Evan, Ewald, Gregory A., Morris, Alanna A., Owens, Anjali, Lowes, Brian, Stoller, Douglas, Tang, W.H. Wilson, Garg, Sonia, Trachtenberg, Barry H., Shah, Palak, Pamboukian, Salpy V., Sweitzer, Nancy K., Wheeler, Matthew T., Wilcox, Jane E., Katz, Stuart, and Pan, Stephen

Published
2023
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227. Indications for Cardiac Resynchronization Therapy: 2011 Update From the Heart Failure Society of America Guideline Committee

Author

Stevenson, William G., Hernandez, Adrian F., Carson, Peter E., Fang, James C., Katz, Stuart D., Spertus, John A., Sweitzer, Nancy K., Tang, W.H. Wilson, Albert, Nancy M., Butler, Javed, Westlake Canary, Cheryl A., Collins, Sean P., Colvin-Adams, Monica, Ezekowitz, Justin A., Givertz, Michael M., Hershberger, Ray E., Rogers, Joseph G., Teerlink, John R., Walsh, Mary N., Stough, Wendy Gattis, and Starling, Randall C.

Published
2012
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230. Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

Author

Mullens, Wilfried, primary, Martens, Pieter, additional, Testani, Jeffrey M., additional, Tang, W.H. Wilson, additional, Skouri, Hadi, additional, Verbrugge, Frederik H., additional, Fudim, Marat, additional, Iacoviello, Massimo, additional, Franke, Jennifer, additional, Flammer, Andreas J., additional, Palazzuoli, Alberto, additional, Barragan, Paola Morejon, additional, Thum, Thomas, additional, Marcos, Marta Cobo, additional, Miró, Òscar, additional, Rossignol, Patrick, additional, Metra, Marco, additional, Lassus, Johan, additional, Orso, Francesco, additional, Jankowska, Ewa A., additional, Chioncel, Ovidiu, additional, Milicic, Davor, additional, Hill, Loreena, additional, Seferovic, Petar, additional, Rosano, Giuseppe, additional, Coats, Andrew, additional, and Damman, Kevin, additional

Published
2022
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236. Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

Author

Shao, Spencer H., Allen, Brian, Clement, Jessica, Chung, Gina, Gao, Jingjing, Hubbell, Earl, Liu, Minetta C., Swanton, Charles, Tang, W.H. Wilson, Yimer, Habte, and Tummala, Mohan

Abstract

There are four solid tumors with common screening options in the average-risk population aged 21 to 75 years (breast, cervical, colorectal, and, based on personalized risk assessment, prostate), but many cancers lack recommended population screening and are often detected at advanced stages when mortality is high. Blood-based multi-cancer early detection tests have the potential to improve cancer mortality through additional population screening. Reported here is a post-hoc analysis from the third Circulating Cell-free Genome Atlas substudy to examine multi-cancer early detection test performance in solid tumors with and without population screening recommendations and in hematologic malignancies. Participants with cancer in the third Circulating Cell-free Genome Atlas substudy analysis were split into three subgroups: solid screened tumors (breast, cervical, colorectal, prostate), solid unscreened tumors, and hematologic malignancies. In this post hoc analysis, sensitivity is reported for each subgroup across all ages and those aged ⩾50 years overall, by cancer, and by clinical cancer stage. Aggregate sensitivity in the solid screened, solid unscreened, and hematologic malignancy subgroups was 34%, 66%, and 55% across all cancer stages, respectively; restricting to participants aged ⩾50 years showed similar aggregate sensitivity. Aggregate sensitivity was 27%, 53%, and 60% across stages I to III, respectively. Within the solid unscreened subgroup, aggregate sensitivity was >75% in 8/18 cancers (44%) and >50% in 13/18 (72%). This multi-cancer early detection test detected cancer signals at high (>75%) sensitivity for multiple cancers without existing population screening recommendations, suggesting its potential to complement recommended screening programs.Clinical trial identifier: NCT02889978.

Published
2023
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241. Incorporation of natriuretic peptides with clinical risk scores to predict heart failure among individuals with dysglycaemia

Author

Segar, Matthew W., primary, Khan, Muhammad Shahzeb, additional, Patel, Kershaw V., additional, Vaduganathan, Muthiah, additional, Kannan, Vaishnavi, additional, Willett, Duwayne, additional, Peterson, Eric, additional, Tang, W.H. Wilson, additional, Butler, Javed, additional, Everett, Brendan M., additional, Fonarow, Gregg C., additional, Wang, Thomas J., additional, McGuire, Darren K., additional, and Pandey, Ambarish, additional

Published
2021
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243. The contributory role of gut microbiota in cardiovascular disease

Author

Tang, W.H. Wilson and Hazen, Stanley L.

Subjects
Medical research, Medicine, Experimental, Microbiota (Symbiotic organisms) -- Health aspects, Host-bacteria relationships -- Research, Cardiovascular diseases -- Risk factors, Health care industry
Abstract

Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/ phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota-dependent formation of TMA and host hepatic flavin monooxygenase 3-dependent (FMO3-dependent) formation of TMA-W-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks. Collectively, these studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD., Introduction Cardiovascular disease (CVD) remains the leading cause of death in both the United States and industrialized societies, with growing incidence in developing countries (1). Factors contributing to CVD arise [...]

Published
2014
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244. Decongestion with Acetazolamide in Acute Decompensated Heart Failure across the Spectrum of Left Ventricular Ejection Fraction: a Pre-specified Analysis from the ADVOR trial.

Author

Martens, Pieter, Dauw, Jeroen, Verbrugge, Frederik H., Nijst, Petra, Meekers, Evelyne, Augusto Jr, Silvio Nunes, Ter Maaten, Jozine M., Damman, Kevin, Mebazaa, Alexandre, Filippatos, Gerasimos, Ruschitzka, Frank, Tang, W.H. Wilson, Dupont, Matthias, Mullens, Wilfried, and Augusto, Silvio Nunes Jr

Published
2023
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247. Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer

Author

Kruse, Megan L., primary, Patel, Mona, additional, McManus, Jeffrey, additional, Chung, Yoon-Mi, additional, Li, Xiuxiu, additional, Wei, Wei, additional, Bazeley, Peter S., additional, Nakamura, Fumihiko, additional, Hardaway, Aimalie, additional, Downs, Erinn, additional, Chandarlapaty, Sarat, additional, Thomas, Mathew, additional, Moore, Halle C.F., additional, Budd, George T., additional, Tang, W.H. Wilson, additional, Hazen, Stanley L., additional, Bernstein, Aaron, additional, Nik-Zainal, Serena, additional, Abraham, Jame, additional, and Sharifi, Nima, additional

Published
2021
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248. Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension

Author

Farha, Samar, primary, Comhair, Suzy, additional, Hou, Yuan, additional, Park, Margaret M., additional, Sharp, Jacqueline, additional, Peterson, Laura, additional, Willard, Belinda, additional, Zhang, Renliang, additional, DiFilippo, Frank P., additional, Neumann, Donald, additional, Tang, W.H. Wilson, additional, Cheng, Feixiong, additional, and Erzurum, Serpil, additional

Published
2021
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249. The Reply

Author

Krittanawong, Chayakrit, primary, Narasimhan, Bharat, additional, Wang, Zhen, additional, Virk, Hafeez Ul Hassan, additional, Farrell, Ann M., additional, Zhang, HongJu, additional, and Tang, W.H. Wilson, additional

Published
2021
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250. Effectiveness of the Family Heart TalkCommunication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial

Author

Kinnamon, Daniel D., Jordan, Elizabeth, Haas, Garrie J., Hofmeyer, Mark, Kransdorf, Evan, Ewald, Gregory A., Morris, Alanna A., Owens, Anjali, Lowes, Brian, Stoller, Douglas, Tang, W.H. Wilson, Garg, Sonia, Trachtenberg, Barry H., Shah, Palak, Pamboukian, Salpy V., Sweitzer, Nancy K., Wheeler, Matthew T., Wilcox, Jane E., Katz, Stuart, Pan, Stephen, Jimenez, Javier, Aaronson, Keith D., Fishbein, Daniel P., Smart, Frank, Wang, Jessica, Gottlieb, Stephen S., Judge, Daniel P., Moore, Charles K., Mead, Jonathan O., Huggins, Gordon S., Ni, Hanyu, Burke, Wylie, and Hershberger, Ray E.

Published
2023
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