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11,088 results on '"Takeuchi, T."'

203. O-130 Reproductive outcomes of normal ovarian reserve patients after progestin-primed ovarian stimulation with chlormadinone acetate vs GnRH antagonist: A retrospective study with inverse-probability-of-treatment weighting

Author

Handa, M, primary, Takiuchi, T, additional, Kawaguchi, S, additional, Komukai, S, additional, Kitamura, T, additional, Miyake, T, additional, Ohara, Y, additional, Doshida, M, additional, Takeuchi, T, additional, Matsubayashi, H, additional, Ishikawa, T, additional, and Kimura, T, additional

Published
2022
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206. Hard x-ray photoemission spectroscopy of rhenium substituted higher manganese silicides.

Author

Matsunami, M., Iizuka, T., Ghodke, S., Yamamoto, A., Miyazaki, H., and Takeuchi, T.

Subjects
PHOTOELECTRON spectroscopy, HARD X-rays, X-ray spectroscopy, MANGANESE, FERMI energy, PHOTOEMISSION, ELECTRONIC structure
Abstract

We have investigated the electronic structure of a potential thermoelectric material, higher manganese silicide, and its solid solutions with supersaturated Re by means of hard x-ray photoemission spectroscopy. The unusual Re substitution dependence of thermoelectric properties in the higher manganese silicide, reducing the electrical resistivity without altering the Seebeck coefficient, can be explained in terms of the variation of the density of states at the Fermi level and its energy derivative. Such an electronic structure variation contributes to an improvement in the thermoelectric performance in combination with the suppressed thermal conductivity. [ABSTRACT FROM AUTHOR]

Published
2020
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207. Fermi Surface and Pseudogap Evolution in a Cuprate Superconductor

Author

He, Yang, Yin, Yi, Zech, M., Soumyanarayanan, Anjan, Yee, Michael M., Williams, Tess, Boyer, M. C., Chatterjee, Kamalesh, Wise, W. D., Zeljkovic, I., Kondo, Takeshi, Takeuchi, T., Ikuta, H., Mistark, Peter, Markiewicz, Robert S., Bansil, Arun, Sachdev, Subir, Hudson, E. W., and Hoffman, J. E.

Published
2014

214. Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Author

Monti, S., Craven, A., Klersy, C., Montecucco, C., Caporali, R., Watts, R., Merkel, P. A., Luqmani, R., Achilleos, K., Adler, M., Alba, M. A., Albert, D. A., Alibaz-Oner, F., Allcoat, P., Amano, K., Amarasuriya, M., Amudala, N. A., Andrews, J., Archer, A. M., Arimura, Y., Atukorala, I., Azevedo, E., Bajad, S., Baldwin, C., Barra, L. J., Baslund, B., Basu, N., Baykal, M., Berger, C., Berglin, E., Besada, E., Bhardwaj, M., Bischof, A., Blockmans, D., Blood, J., Draibe, J. B., Brand, S., Brandao, M., Bruce, I. N., Butler, A., Calabrese, L. H., Ferrer, D. C., Carette, S., Carmona, D., Ceunen, H., Chakravarty, K., Chapman, P. T., Chocova, Z., Chung, S. A., Ci, W., Cid, M. C., Clark, T. M., Clarkson, M. R., De Jesus Contreras-Rodriguez, F., Conway, R., Cooke, K., Viros, X. C., Cordeiro, A., Costa, A., Culfear, K., Daikeler, T., Danda, D., Das, S. K., Dasgupta, B., De Castro, A. M., Dehghan, N., Devassy, R., Dhindsa, N., Diamantopoulos, A. P., Direskeneli, H., Dobashi, H., Juan, D., Durrani, M., Edelsten, C., Eifert, J., Elhayek, S., Elsideeg, S., Endo, T., Erden, A., Erer, B., Eriksson, P., Erturk, Z., Espigol-Frigole, G., Felicetti, M., Ferraro, A., Ferro, J. M., Fifi-Mah, A., Flores-Suarez, L. F., Flossmann, O., Flynn, D., Fonseca, J. E., Foot, J., Foote, M., Forbess, L., Fujimoto, S., Fukuoka, K., Furtado, C., Furuta, S., Gaffo, A. L., Gallagher, P., Gao, N., Gatenby, P., Gendi, N., Geraldes, R., Gerits, A., Gioffredi, A., Gomples, L., Goncalves, M. J., Gondo, P., Graham, A., Grainger, R., Gray, D. T., Grayson, P. C., Griffiths, L., Guo, Y., Gupta, R., Gylling, M., Hajj-Ali, R. A., Hammam, N., Harigai, M., Hartley, L., Haslett, J., Hassan, A., Hatemi, G., Hellmich, B., Henckaerts, L., Henes, J. C., Hepburn, J., Herd, V., Hess, C., Hill, C., Hinojosa-Azaola, A., Hirahashi, J., Hirano, F., Hocevar, A., Holle, J., Hollinger, N., Homma, S., Howard, T., Hoyles, R. K., Hruskova, Z., Hutcheon, G., Ignacak, M., Igney-Oertel, A., Ikeda, K., Ikegaya, N., Jagadeesh, S., Jaquith, J., Jayne, D. R. W., Jewell, T., Jones, C., Joshi, A., Kalyoncu, U., Kamall, S., Kamath, S., Lai, K. S., Kaname, S., Kanchinadham, S., Karadag, O., Karube, M., Kaszuba, M., Kaur, R., Kawakami, T., Kawashima, S., Khalidi, N., Khan, A., Kikuchi, M., Kilic, L., Kimura, M., King, M. J., Klapa, S., Klocke, R., Kobayashi, T., Kobayashi, S., Komagata, Y., Kronbichler, A., Kuczia, P., Kumar, M. S., Kurosawa, M., Lamprecht, P., Langford, C. A., Lanyon, P., Laversuch, C., Lee, S. J., Leoni, S., Li, J., Liang, K., Liang, P., Liao, H., Lee, L. A., Luqmani, R. A., Lyle, A., Macdonald, M., Mackie, S. L., Madden, L., Magliano, M., Makino, H., Makol, A., Malaiya, R., Malaviya, A., Manthri, R., Maritati, F., Da Silva, A. M., Mason, J. C., Matara, C., Matsui, K., Matteson, E. L., Mcbride, D., Mccullough, K., Mcgeoch, L., Mclaren, J., Mcmillian, C., Mendiratta, N., Menon, A., Merinopoulos, D., Merkel, P., Messier, S., Micheletti, R. G., Mills, K., Milman, N., Minoda, M., Minz, R. W., Mock, C., Mohammad, A. J., Moiseev, S., Moitinho, M., Molloy, E., Monach, P. A., Montgomery, M., Moosig, F., Moradizadeh, M., Morgan, M., Morgan, A. W., Morgan, A. -M., Muir, A., Mukhtyar, C., Muller, A., Muratore, F., Muso, E., Nada, R., Nakajima, H., Nakajima, T., Nakano, H., Nandagudi, A., Neumann, T., Y. F., Ng, K. H., Ng, Nogueira, E. L., Nolkha, N., Nordstrom, D., Novikov, P., Nugaliyadde, A., O'Donnell, J. L., O'Donoghue, J., O'Neill, L., O'Riordan, E., Oatley, M., Okubo, K., Oliva, E., Oshikawa, H., Ota, Y., Padoan, R., Pagnoux, C., Pan, L., Panaritis, K., Park, J. K., Patel, S., Patil, P., Pazzola, G., Peall, A., Pearce, F., Pehlevan, S., Pereira, L., Pettersson, T., Pineau, C. A., Pirila, L., Poglodek, B., Ponte, C., Prieto-Gonzalez, S., Priya, S. R., Purewal, B., Purschke, S., Putaala, J., Quickert, S., Quincey, V., Raghuvanshi, S., Rajasekhar, L., Ranganathan, D., Rathi, M., Rees, D., Rees, F., Renken, U., Restuccia, G., Rhee, R. L., Rice, B., Robins, D., Robson, J., Rodrigues, M., Romao, V. C., Rotar, C., Ruediger, C., Rutgers, A., A. C., Sa, Saavedra, M. J., Sada, K. -E., Sahbudin, I., Salvarani, C., Sandhu, N., Santos, E., Sato, Y., Schafer, V. S., Schiavon, F., Schmidt, W. A., Segelmark, M., Shahin, A., Sharma, A., Shotton, J., Silva, C., Singer, O. G., Sivasuthan, G., Smolen, S., Solanich-Moreno, X., Boixader, L. S., Song, Y. W., Springer, J., Sreih, A. G., Srivastava, R., Stamp, L. K., Stevens, R., Strbian, D., Sugino, K., Sunderkotter, C., Suppiah, R., Suzuki, K., Szekanecz, Z., Sznajd, J., Taimen, K., Tak, P. P., Takeuchi, T., Takizawa, N., Tames, L., Tan, B. E., Tanaka, M., Tang, M. W., Tatlisumak, T., Tesar, V., Thomas, A., Tian, X., Tokunaga, K., Tombetti, E., Tomsic, M., Toz, B., Tsukamoto, T., Uchida, S., Unal, A. U., Urban, M. L., Usui, J., Vaglio, A., Venkatachalam, S., Vermaak, E., Viswanath, V., Wada, T., Wagh, S., Wallace, D. J., Walters, G., Walz, B., Wan, J., Wang, T., Wang, G., Warrington, K. J., Watts, R. A., Wawrzycka-Adamczyk, K., Weeratunga, P., Weisman, M. H., Wickramasinghe, S., Williams, M., Wojcik, K., Woodruff, L., Xenitidis, T., Yamada, H., Yamagata, K., Yee, C. -S., Yoon, M., Yoshida, K., Yoshifuji, H., Ytterberg, S. R., Yumura, W., Zayed, H., Zeng, X., Zhao, M. -H., Zugaj, A., Zuk, J., İç Hastalıkları, Clinical Haematology, and Translational Immunology Groningen (TRIGR)

Subjects
Male, Outcome, Antineutrophil Cytoplasmic, 030232 urology & nephrology, 0302 clinical medicine, Risk Factors, 80 and over, Pharmacology (medical), Age of Onset, Young adult, Aged, 80 and over, education.field_of_study, age, anti-neutrophil cytoplasmic antibody-associated vasculitis, outcome, Adolescent, Adult, Aged, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antibodies, Antineutrophil Cytoplasmic, Female, Humans, Middle Aged, Morbidity, Prognosis, Retrospective Studies, Risk Assessment, Survival Rate, United Kingdom, Young Adult, Vasculitis, Systemic vasculitis, medicine.medical_specialty, Population, anti-neutrophil cytoplasmic antibody–associated vasculitis, Antibodies, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, education, Anti-neutrophil cytoplasmic antibody–associated vasculitis, Survival rate, Anti-neutrophil cytoplasmic antibody, 030203 arthritis & rheumatology, business.industry, Retrospective cohort study, medicine.disease, Age of onset, business
Abstract

Objectives ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- and older-onset patients are still incompletely understood. Methods We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: Results A total of 1338 patients with AAV were included: 66% had disease onset at Conclusion Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients.

Published
2021

215. POS0247 GLUCOCORTICOID TAPERING STRATEGY FOR ANCA-ASSOCIATED VASCULITIS: ADDRESSING THE GAP BETWEEN RECOMMENDATIONS AND REAL-WORLD PRACTICE

Author

Nishioka, R., primary, Mizushima, I., additional, Kida, T., additional, Omura, S., additional, Nakagomi, D., additional, Masatoshi, K., additional, Takizawa, N., additional, Nomura, A., additional, Yuji, K., additional, Kondo, N., additional, Yasuhiko, Y., additional, Yanagida, T., additional, Endo, K., additional, Hirata, S., additional, Kawahata, K., additional, Matsui, K., additional, Takeuchi, T., additional, Ichinose, K., additional, Kato, M., additional, Yanai, R., additional, Matsuo, Y., additional, Shimojima, Y., additional, Yamasaki, A., additional, Takata, T., additional, Ito, T., additional, Moriyama, M., additional, Takatani, A., additional, Miyawaki, Y., additional, Ito-Ihara, T., additional, Kawaguchi, T., additional, Yajima, N., additional, Kawahito, Y., additional, and Kawano, M., additional

Published
2022
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216. OP0062 EFFICACY AND SAFETY OF ADALIMUMAB WITH LOW AND HIGH DOSE-METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH INADEQUATE RESPONSE TO METHOTREXATE: THE RANDOMISED CONTROLLED MIRACLE STUDY

Author

Tamai, H., primary, Ikeda, K., additional, Miyamoto, T., additional, Taguchi, H., additional, Kuo, C. F., additional, Shin, K., additional, Hirata, S., additional, Okano, Y., additional, Sato, S., additional, Yasuoka, H., additional, Choi, I. A., additional, Park, S. H., additional, Weng, M. Y., additional, Kuwana, M., additional, Lee, Y. J., additional, Ishii, T., additional, Kim, J., additional, Kameda, H., additional, Kojima, T., additional, Baek, H. J., additional, Hsu, P. N., additional, Huang, C. M., additional, Cheng, T. T., additional, Sung, W. Y., additional, Taninaga, T., additional, Mori, M., additional, Miyagishi, H., additional, Sato, Y., additional, Takeuchi, T., additional, and Kaneko, Y., additional

Published
2022
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217. POS0459 APTAMER-BASED PROTEOMIC SCREENING IN IDENTIFICATION OF PATHOGENIC SIGNAL PATHWAY AND URINARY BIOMARKERS ASSOCIATED WITH HISTOLOGICAL FINDINGS IN LUPUS NEPHRITIS

Author

Hiramoto, K., primary, Saito, S., additional, Hanaoka, H., additional, Suzuki, K., additional, Kikuchi, J., additional, Fukui, H., additional, Takano, R., additional, Miyoshi, F., additional, Seki, N., additional, Sugahara, K., additional, Kaneko, Y., additional, and Takeuchi, T., additional

Published
2022
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218. POS0097 IDENTIFICATION OF NEW CANDIDATE DRUGS FOR PRIMARY SJÖGREN’S SYNDROME USING A DRUG REPURPOSING TRANSCRIPTOMIC APPROACH

Author

Felten, R., primary, Ye, T., additional, Schleiss, C., additional, Schwikowski, B., additional, Sibilia, J., additional, Monneaux, F., additional, Dumortier, H., additional, Jonsson, R., additional, Lessard, C., additional, Ng, W. F., additional, Takeuchi, T., additional, Mariette, X., additional, and Gottenberg, J. E., additional

Published
2022
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220. POS0822 HYPERTROPHIC PACHYMENINGITIS IN ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS: A MULTICENTER SURVEY IN JAPAN

Author

Shimojima, Y., primary, Kishida, D., additional, Ichikawa, T., additional, Kida, T., additional, Yajima, N., additional, Omura, S., additional, Nakagomi, D., additional, Abe, Y., additional, Masatoshi, K., additional, Takizawa, N., additional, Nomura, A., additional, Kukida, Y., additional, Kondo, N., additional, Yasuhiko, Y., additional, Yanagida, T., additional, Endo, K., additional, Hirata, S., additional, Kawahata, K., additional, Matsui, K., additional, Takeuchi, T., additional, Ichinose, K., additional, Kato, M., additional, Yanai, R., additional, Matsuo, Y., additional, Yamasaki, A., additional, Nishioka, R., additional, Takata, T., additional, Moriyama, M., additional, Takatani, A., additional, Ito, T., additional, Miyawaki, Y., additional, Ito-Ihara, T., additional, Kawaguchi, T., additional, Kawahito, Y., additional, and Sekijima, Y., additional

Published
2022
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221. POS0121 ASSOCIATION OF LUPUS LOW DISEASE ACTIVITY STATE ATTAINMENT WITH REDUCED ORGAN DAMAGE AND FLARE IN SLE PATIENTS WITH HIGH DISEASE ACTIVITY

Author

Kandane-Rathnayake, R., primary, Golder, V., additional, Louthrenoo, W., additional, Chen, Y. H., additional, Cho, J., additional, Lateef, A., additional, Hamijoyo, L., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, Zamora, L., additional, Li, Z., additional, An, Y., additional, Sockalingam, S., additional, Katsumata, Y., additional, Harigai, M., additional, Hao, Y., additional, Zhang, Z., additional, Basnayake, B., additional, Chan, M., additional, Kikuchi, J., additional, Takeuchi, T., additional, Bae, S. C., additional, Oon, S., additional, O’neill, S., additional, Goldblatt, F., additional, Gibson, K., additional, Ng, K., additional, Law, A., additional, Tugnet, N., additional, Kumar, S., additional, Tee, C., additional, Tee, M., additional, Tanaka, Y., additional, Lau, C. S., additional, Nikpour, M., additional, Morand, E. F., additional, and Hoi, A., additional

Published
2022
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223. AB0394 CLINICAL OUTCOMES UP TO WEEK 48 OF ONGOING FILGOTINIB (FIL) RHEUMATOID ARTHRITIS (RA) LONG-TERM EXTENSION (LTE) TRIAL OF BIOLOGIC DISEASE-MODIFYING ANTIRHEUMATIC DRUG (bDMARD) INADEQUATE RESPONDERS (IR) INITIALLY ON FIL OR PLACEBO IN A PHASE 3 PARENT STUDY (PS)

Author

Buch, M. H., primary, Takeuchi, T., additional, Rajendran, V., additional, Gottenberg, J. E., additional, Pechonkina, A., additional, Tan, Y., additional, Gong, Q., additional, Van Beneden, K., additional, and Caporali, R., additional

Published
2022
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225. OP0142 COMPARISON OF ATTAINMENT AND PROTECTIVE EFFECTS OF THE LUPUS LOW DISEASE ACTIVITY STATE IN PATIENTS WITH NEWLY DIAGNOSED VERSUS ESTABLISHED SLE - A MULTICENTRE PROSPECTIVE STUDY

Author

Golder, V., primary, Kandane-Rathnayake, R., additional, Louthrenoo, W., additional, Chen, Y. H., additional, Cho, J., additional, Lateef, A., additional, Hamijoyo, L., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, Zamora, L., additional, LI, Z., additional, An, Y., additional, Sockalingam, S., additional, Katsumata, Y., additional, Harigai, M., additional, Hao, Y., additional, Zhang, Z., additional, Basnayake, B., additional, Chan, M., additional, Kikuchi, J., additional, Takeuchi, T., additional, Bae, S. C., additional, O’neill, S., additional, Goldblatt, F., additional, Oon, S., additional, Gibson, K., additional, Ng, K., additional, Law, A., additional, Tugnet, N., additional, Kumar, S., additional, Tee, C., additional, Tee, M., additional, Tanaka, Y., additional, Lau, C. S., additional, Nikpour, M., additional, Hoi, A., additional, and Morand, E. F., additional

Published
2022
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227. AB0625 Association between Cytomegalovirus Reactivation and Renal Prognosis during Remission Induction Therapy for ANCA-Associated Vasculitis

Author

Kawamori, K., primary, Oguro, N., additional, Kida, T., additional, Omura, S., additional, Nakagomi, D., additional, Masatoshi, K., additional, Takizawa, N., additional, Nomura, A., additional, Yuji, K., additional, Kondo, N., additional, Yasuhiko, Y., additional, Yanagida, T., additional, Endo, K., additional, Hirata, S., additional, Kawahata, K., additional, Matsui, K., additional, Takeuchi, T., additional, Ichinose, K., additional, Kato, M., additional, Yanai, R., additional, Matsuo, Y., additional, Shimojima, Y., additional, Nishioka, R., additional, Yamasaki, A., additional, Takata, T., additional, Ito, T., additional, Moriyama, M., additional, Takatani, A., additional, Miyawaki, Y., additional, Kawahito, Y., additional, Ito-Ihara, T., additional, Kawaguchi, T., additional, and Yajima, N., additional

Published
2022
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228. POS0664 RADIOGRAPHIC CHANGE IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ESTIMATED BASELINE YEARLY PROGRESSION ≥5 OR <5: POST HOC ANALYSIS OF TWO PHASE 3 TRIALS OF FILGOTINIB

Author

Tanaka, Y., primary, Atsumi, T., additional, Aletaha, D., additional, Landewé, R. B. M., additional, Bartok, B., additional, Pechonkina, A., additional, Yin, Z., additional, Han, L., additional, Emoto, K., additional, Kano, S., additional, Rajendran, V., additional, and Takeuchi, T., additional

Published
2022
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231. Development of Nb3Al Superconductors

Author

Inoue, K., Takeuchi, T., Iijima, Y., Kikuchi, A., Nakagawa, N., Iwaki, G., Moriai, H., Watanabe, K., Kawazoe, Yoshiyuki, editor, Hasegawa, Masayuki, editor, Inoue, Akihisa, editor, Kobayashi, Norio, editor, Sakurai, Toshio, editor, Wille, Luc, editor, Watanabe, Kazuo, editor, and Motokawa, Mitsuhiro, editor

Published
2002
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232. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis

Author

Grayson, P. C., Ponte, C., Suppiah, R., Robson, J. C., Craven, A., Judge, A., Khalid, S., Hutchings, A., Luqmani, R. A., Watts, R. A., Merkel, P. A., Gatenby, P., Hill, C., Ranganathan, D., Kronbichler, A., Blockmans, D., Barra, L., Carette, S., Pagnoux, C., Dhindsa, N., Fifi-Mah, A., Khalidi, N., Liang, P., Milman, N., Pineau, C., Tian, X., Wang, G., Wang, T., Zhao, M. -H., Tesar, V., Baslund, B., Hammam, N., Shahin, A., Pirila, L., Putaala, J., Hellmich, B., Henes, J., Lamprecht, P., Neumann, T., Schmidt, W., Sunderkoetter, C., Szekanecz, Z., Danda, D., Das, S., Gupta, R., Rajasekhar, L., Sharma, A., Wagh, S., Clarkson, M., Molloy, E., Salvarani, C., Schiavon, F., Tombetti, E., Vaglio, A., Amano, K., Arimura, Y., Dobashi, H., Fujimoto, S., Harigai, M., Hirano, F., Hirahashi, J., Honma, S., Kawakami, T., Kobayashi, S., Kono, H., Makino, H., Matsui, K., Muso, E., Suzuki, K., Ikeda, K., Takeuchi, T., Tsukamoto, T., Uchida, S., Wada, T., Yamada, H., Yamagata, K., Yumura, W., Lai, K. S., Flores-Suarez, L. F., Hinojosa, A., Rutgers, B., Tak, P. -P., Grainger, R., Quincey, V., Stamp, L., Besada, E., Diamantopoulos, A., Sznajd, J., Azevedo, E., Geraldes, R., Rodrigues, M., Santos, E., Song, Y. -W., Moiseev, S., Hocevar, A., Cid, M. C., Moreno, X. S., Atukorala, I., Berglin, E., Mohammed, A., Segelmark, M., Daikeler, T., Direskeneli, H., Hatemi, G., Kamali, S., Karadag, O., Pehlevan, S., Adler, M., Basu, N., Bruce, I., Chakravarty, K., Dasgupta, B., Flossmann, O., Gendi, N., Hassan, A., Hoyles, R., Jayne, D., Jones, C., Klocke, R., Lanyon, P., Laversuch, C., Luqmani, R., Robson, J., Magliano, M., Mason, J., Maw, W. W., Mcinnes, I., Mclaren, J., Morgan, M., Morgan, A., Mukhtyar, C., O'Riordan, E., Patel, S., Peall, A., Venkatachalam, S., Vermaak, E., Menon, A., Watts, R., Yee, C. -S., Albert, D., Calabrese, L., Chung, S., Forbess, L., Gaffo, A., Gewurz-Singer, O., Grayson, P., Liang, K., Matteson, E., Springer, J., Sreih, A., and Translational Immunology Groningen (TRIGR)

Subjects
Adult, Male, Vasculitis, Myeloblastin, Immunology, Churg-Strauss Syndrome, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Antibodies, Antineutrophil Cytoplasmic, Diagnosis, Differential, Rheumatology, Risk Factors, Humans, Immunology and Allergy, anti-neutrophil cytoplasm antibody, Prospective Studies, Aged, Granulomatosis with Polyangiitis, Reproducibility of Results, Middle Aged, United States, Female, eosinophilic granulomatosis with polyangiitis, Eosinophilic Granuloma, Europe, classification, Societies
Abstract

ObjectiveTo develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA).MethodsPatients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate criteria items using consensus methodology, (2) prospective collection of candidate items present at the time of diagnosis, (3) data-driven reduction of the number of candidate items, (4) expert panel review of cases to define the reference diagnosis and (5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators.ResultsThe development set for EGPA consisted of 107 cases of EGPA and 450 comparators. The validation set consisted of an additional 119 cases of EGPA and 437 comparators. From 91 candidate items, regression analysis identified 11 items for EPGA, 7 of which were retained. The final criteria and their weights were as follows: maximum eosinophil count ≥1×109/L (+5), obstructive airway disease (+3), nasal polyps (+3), cytoplasmic antineutrophil cytoplasmic antibody (ANCA) or anti-proteinase 3–ANCA positivity (−3), extravascular eosinophilic predominant inflammation (+2), mononeuritis multiplex/motor neuropathy not due to radiculopathy (+1) and haematuria (−1). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having EGPA if the cumulative score was ≥6 points. When these criteria were tested in the validation data set, the sensitivity was 85% (95% CI 77% to 91%) and the specificity was 99% (95% CI 98% to 100%).ConclusionThe 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis demonstrate strong performance characteristics and are validated for use in research.

Published
2022

241. Profil de tolérance jusqu’à 9,3 ans de baricitinib dans le traitement de la polyarthrite rhumatoïde : mise à jour d’une analyse intégrée de la tolérance

Author

Taylor, P.C., primary, Takeuchi, T., additional, Burmester, G.R., additional, Durez, P., additional, Smolen, J., additional, Deberdt, W., additional, Xie, L., additional, Zhong, J., additional, Torres, J.R., additional, Bello, N., additional, Winthrop, K., additional, and Combe, B., additional

Published
2021
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243. The Herschel ATLAS

Author

Eales, S., Dunne, L., Clements, D., Cooray, A., De Zotti, G., Dye, S., Ivison, R., Jarvis, M., Lagache, G., Maddox, S., Negrello, M., Serjeant, S., Thompson, M. A., Kampen, E. Van, Amblard, A., Andreani, P., Baes, M., Beelen, A., Bendo, G. J., Benford, D., Bertoldi, F., Bock, J., Bonfield, D., Boselli, A., Bridge, C., Buat, V., Burgarella, D., Carlberg, R., Cava, A., Chanial, P., Charlot, S., Christopher, N., Coles, P., Cortese, L., Dariush, A., da Cunha, E., Dalton, G., Danese, L., Dannerbauer, H., Driver, S., Dunlop, J., Fan, L., Farrah, D., Frayer, D., Frenk, C., Geach, J., Gardner, J., Gomez, H., González-Nuevo, J., González-Solares, E., Griffin, M., Hardcastle, M., Hatziminaoglou, E., Herranz, D., Hughes, D., Ibar, E., Jeong, Woong-Seob, Lacey, C., Lapi, A., Lawrence, A., Lee, M., Leeuw, L., Liske, J., López-Caniego, M., Müller, T., Nandra, K., Panuzzo, P., Papageorgiou, A., Patanchon, G., Peacock, J., Pearson, C., Phillipps, S., Pohlen, M., Popescu, C., Rawlings, S., Rigby, E., Rigopoulou, M., Robotham, A., Rodighiero, G., Sansom, A., Schulz, B., Scott, D., Smith, D. J. B., Sibthorpe, B., Smail, I., Stevens, J., Sutherland, W., Takeuchi, T., Tedds, J., Temi, P., Tuffs, R., Trichas, M., Vaccari, M., Valtchanov, I., van der Werf, P., Verma, A., Vieria, J., Vlahakis, C., and White, Glenn J.

Published
2010
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244. Characterization of a novel Entamoeba histolytica strain from Burkina Faso, Africa, possessing a unique hexokinase-2 gene

Author

Suzuki J., Kobayashi S., Imada M., Tolba M.E., and Takeuchi T.

Subjects
Entamoeba histolytica, isoenzyme, hexokinase, genetic variation, isoelectric focusing, Infectious and parasitic diseases, RC109-216
Abstract

An Entamoeba histolytica strain (BF-841 cl1) that originated from Burkina Faso, Africa presented with novel, polymorphic genotypes of the serine-rich E. histolytica protein and the anodic hexokinase-2 (HXK-2) isoenzyme band, which showed less electrophoretic mobility than that of an E. histolytica reference strain [HM-1:IMSS cl6 (zymodeme (Z)-II)] by starch gel electrophoresis and isoelectric focusing (IEF). The HXK-2 gene of BF-841 cl1 had amino acid variations at four positions compared to the sequence of HM-1: IMSS cl6. These variations were absent from the sequences of four other E. histolytica strains with different zymodemes [KU27 (Z-II), SAW1627 (Z-IIα-), SAW755CR clB (Z-XIV), and KU2 (Z-XIX)]. The results of IEF showed no difference in the substrate specificity of HXK (HXK-1 and HXK-2) between BF-841 cl1 and the three reference E. histolytica strains (HM-1:IMSS cl6, SAW755 clB, and KU27). It was also confirmed that BF-841 cl1 was able to form liver abscesses in Syrian hamsters.

Published
2011
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