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201. Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells

Author

Ren,Fang, Shrestha,Christina, Shi,Huirong, Sun,Fangfang, Zhang,Minghui, Cao,Yuan, and Li,Gailing

Subjects
OncoTargets and Therapy
Abstract

Fang Ren, Christina Shrestha, Huirong Shi, Fangfang Sun, Minghui Zhang, Yuan Cao, Gailing Li Department of Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Fang RenDepartment of Gynecology, First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, People’s Republic of ChinaTel +8613849115866Email renfang@foxmail.comPurpose: The retinoblastoma binding protein RBP2 (KDM5A) is a histone demethylase that promotes cell growth in many human cancers. A series of functional experiments were conducted to explore the role of miR-421/KDM5A in ovarian cancer cells and their underlying molecular mechanisms.Materials and Methods: Public microarray databases were analyzed to assess KDM5A and miR-421 expression in ovarian cancer. KDM5A was predicted to be a target of miR-421 using software analysis. The expression of the miR-421/KDM5A regulatory axis in ovarian cancer and the mechanisms of its effects on proliferation, migration, and invasion of ovarian cancer cell lines were investigated.Results: Compared with normal ovarian tissues, the expression of KDM5A mRNA and protein was elevated (P< 0.05), and miR-421 expression was reduced in ovarian cancer tissue (P< 0.05). miR-421 was found to bind specifically to the KDM5A gene. Silencing KDM5A or overexpressing miR-421 significantly inhibited proliferation, migration, and invasion of OVCAR-8 and SKOV-3 cells. Similarly, compared with nude mice injected with cells transfected with empty capsids, the in vivo proliferation rate of OVCAR-8 cells after miR-421 overexpression was reduced significantly.Conclusion: The miR-421/KDM5A regulatory axis plays an important role in the development and progression of ovarian cancer cells.Keywords: ovarian cancer, KDM5A/RBP2, miR-421, progression

Published
2020

204. Author Correction: Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

Author

Huang, Yubin, primary, Xu, Zhen, additional, Xiong, Shanshan, additional, Sun, Fangfang, additional, Qin, Guangrong, additional, Hu, Guanglei, additional, Wang, Jingjing, additional, Zhao, Lei, additional, Liang, Yu-Xiang, additional, Wu, Tianzhun, additional, Lu, Zhonghua, additional, Humayun, Mark S., additional, So, Kwok-Fai, additional, Pan, Yihang, additional, Li, Ningning, additional, Yuan, Ti-Fei, additional, Rao, Yanxia, additional, and Peng, Bo, additional

Published
2020
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210. Is market index autocorrelation attributable to price latency? Evidence from CSI500.

Author

Li, Meng, Qiao, Lixin, and Sun, Fangfang

Subjects
STOCK price indexes, RATE of return on stocks, PRICE indexes
Abstract

This article discusses the autocorrelation in daily returns of the China Stock Index 500 (CSI500) from the perspective of price latency due to price limit mechanism. We propose limit-up/limit-down (LULD) indices to quantify the price latency in CSI500 as an aggregated number of component stocks closing with LULD in a given trading day. We found that the positive autocorrelation in the CSI500 market index during the data period disappeared after the price latency was controlled. This implies that the autocorrelation we observed may be attributable to the price latency measured by LULD indices. Our findings provide new insight into the dynamic features of market indices and may serve as a workable reference for practical usage of the market index. [ABSTRACT FROM AUTHOR]

Published
2022
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226. Neurofibromatosis type I with malignant peripheral nerve sheath tumors in the upper arm

Author

Zhang, Lili, Sun, Fangfang, Li, Hongyu, Du, Jie, and Zhao, Lirong

Subjects
Male, Young Adult, Neurofibromatosis 1, Peripheral Nervous System Neoplasms, neurofibromatosis type I, Arm, case report, Humans, malignant peripheral nerve sheath tumor, Clinical Case Report, Research Article
Abstract

Rationale: Malignant peripheral nerve sheath tumor occurring in the context of neurofibromatosis type I (NF1) is relatively rare. Herein, we report a case of NF1 with malignant peripheral nerve sheath tumor in the upper arm. Patient concerns: A 24-year-old man presented with a mass in the medial part of the left upper arm that had been present for more than 20 years. In the previous 1 year prior to admission, the mass had grown significantly. Physical examination showed cafe-au-lait spots of variable sizes throughout the body and multiple masses in the medial part of the left upper arm. Three months later after the resection of the masses, the patient was readmitted to our department due to tumor recurrence. Two months after the extended resection, in situ recurrence of the tumor was noted again. Four months after the operation and the administration of radiotherapy, a mass was found in the outside of the left upper arm. Diagnosis: Immunohistochemical staining showed the masses were positivity for vimentin, CD34, and S100; the tumor cells were negative for PGP9.5, CD57, EMA, and SMA. The Ki-67 labeling index was approximately 40%. A diagnosis of malignant peripheral nerve sheath tumor was made. Interventions: Surgical resection was performed for both the primary tumors and the 2 subsequent recurrence tumors. The patient underwent radiotherapy with 60 Gy in 30 fractions after the third operation. Four months after the administration of radiotherapy, the patient underwent tumorectomy of a mass in the outside of the left upper arm. Outcomes: During the 4-month follow-up after the fourth operation, the patient's condition was stable. Lessons: Malignant peripheral nerve sheath tumor in NF1 is an exceedingly rare entity that poses a great diagnostic challenge. High-frequency ultrasound can support the diagnosis.

Published
2019

231. Intravesical contrast-enhanced ultrasound (CEUS) for the diagnosis of vesicouterine fistula (VUF)

Author

Sun, Fangfang, Cui, Lifeng, Zhang, Lili, Hao, Jianxun, Gu, Jinhua, Du, Jie, and Zhao, Lirong

Subjects
vesicouterine fistula (VUF), Adult, Uterine Diseases, Fistula, contrast-enhanced ultrasound (CEUS), Humans, Female, Clinical Case Report, urogenital fistula, Research Article, Ultrasonography
Abstract

Background: Vesicouterine fistula (VUF) is a very rare type of urogenital fistula, the incidence of which has increased in recent years due to increased cesarean section deliveries and other pelvic surgeries. The clinical diagnosis of VUF is typically challenging. Case: A 31-year-old woman who presented with fever, increase urine frequency, and urinary incontinence at night, along with occasional vaginal discharge after cesarean section. The VUF was misdiagnosed on conventional ultrasound, but was successfully diagnosed by using intravesical contrast-enhanced ultrasound (CEUS) using SonoVue, which was confirmed by the subsequent cystoscopy. Conclusion: Intravesical CEUS provides a new effective method for diagnosing VUF, which may become the first choice for diagnosing urogenital fistulas.

Published
2018

249. CD4+CXCR4+ T cells as a novel prognostic biomarker in patients with idiopathic inflammatory myopathy-associated interstitial lung disease

Author

Wang, Kaiwen, primary, Zhao, Jiangfeng, additional, Chen, Zhiwei, additional, Li, Ting, additional, Tan, Xiaoming, additional, Zheng, Yu, additional, Gu, Liyang, additional, Guo, Li, additional, Sun, Fangfang, additional, Wang, Haiting, additional, Li, Jiajie, additional, Wang, Xiaodong, additional, Riemekasten, Gabriela, additional, and Ye, Shuang, additional

Published
2018
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