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781 results on '"Strasser, Ruth H."'

203. Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin.

Author

Petzold, Cathleen, Steinbronn, Nadine, Gereke, Marcus, Strasser, Ruth H., Sparwasser, Tim, Bruder, Dunja, Geffers, Robert, Schallenberg, Sonja, and Kretschmer, Karsten

Abstract

Under physiological conditions, studies on the biology of naturally induced Foxp3+ Treg cells of intra- and extrathymic origin have been hampered by the lack of unambiguous markers to discriminate the mature progeny of such developmental Treg-cell sublineages. Here, we report on experiments in double-transgenic mice, in which red fluorescent protein (RFP) is expressed in all Foxp3+ Treg cells, whereas Foxp3-dependent GFP expression is exclusively confined to intrathymically induced Foxp3+ Treg cells. This novel molecular genetic tool enabled us to faithfully track and characterize naturally induced Treg cells of intrathymic (RFP+GFP+) and extrathymic (RFP+GFP-) origin in otherwise unmanipulated mice. These experiments directly demonstrate that extrathymically induced Treg cells substantially contribute to the overall pool of mature Foxp3+ Treg cells residing in peripheral lymphoid tissues of steady-state mice. Furthermore, we provide evidence that intra- and extrathymically induced Foxp3+ Treg cells represent distinct phenotypic and functional sublineages. [ABSTRACT FROM AUTHOR]

Published
2014
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215. The expression of macrophage migration inhibitory factor 1α (MIF 1α) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability

Author

Schmeisser, Alexander, primary, Marquetant, Rainer, additional, Illmer, Thomas, additional, Graffy, Christiane, additional, Garlichs, Christoph D., additional, Böckler, Dittmar, additional, Menschikowski, Dittmar, additional, Braun-Dullaeus, Ruediger, additional, Daniel, Werner G., additional, and Strasser, Ruth H., additional

Published
2005
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221. Antiinflammatory and antiangiogenetic effect of ramiprilat: Angiotensin converting enzyme inhibition in monocytes prevents their angiotensin II- and hypoxia-induced cytokine expression by downregulation of AT-1 receptor expression and NF-kappaB activation

Author

Schmeisser, Alexander, primary, Soehnlein, Oliver, additional, Illmer, Thomas, additional, Garlichs, Christoph, additional, Lorenz, Hannes, additional, Ehninger, Gerhard, additional, Daniel, Werner G., additional, and Strasser, Ruth H., additional

Published
2003
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222. The coexpression of the migration inhibiting factor 1-alpha with CD401 in human atherosclerotic plaques is associated with advanced plaque stages and extent of intraplaque inflammation

Author

Schmeisser, Alexander, primary, Illmer, Thomas, additional, Graffy, Christiane, additional, Loesel-Sadee, Herribert, additional, Boeckler, Dittmar, additional, Menschikowski, Dittmar, additional, Ehninger, Gerhard, additional, Garlichs, Christoph, additional, Daniel, Werner G., additional, and Strasser, Ruth H., additional

Published
2003
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227. Idiopathic clubbing

Author

Baragwanath, Philip, Reynen, Klaus, and Strasser, Ruth H.

Subjects
Fingers -- Abnormalities
Published
2001

230. Heart-type fatty acid-binding protein and myocardial creatine kinase enable rapid risk stratification in normotensive patients with pulmonary embolism

Author

Langer, Martin, Forkmann, Mathias, Richter, Utz, Tausche, Anne-Kathrin, Sveric, Krunoslav, Christoph, Marian, Ibrahim, Karim, Günther, Michael, Kolschmann, Steffen, Boscheri, Alessandra, Barthel, Peggy, Strasser, Ruth H., and Wunderlich, Carsten

Abstract

Risk assessments of hemodynamically stable patients with pulmonary embolisms (PE) remain challenging. In this context heart-type fatty acid–binding protein (H-FABP), creatine kinase isoenzyme MB (CK-MB), and troponin I (TnI) may hold prognostic utility for patients with pulmonary embolism.

Published
2016
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233. Aortic dissection albeit negative d-dimers and zero clinical probability – Another facet of medicine's deadly chameleon.

Author

Ruf, Tobias Friedrich, Pfluecke, Christian, Mues, Christoph, and Strasser, Ruth H.

Abstract

Aortic dissection, the rupture of the aorta's intimal and medial layers, leading to the formation of a false lumen, is a relatively common disease with high mortality. So far, while not addressing penetrating aortic ulcer or intramural hematoma, current guidelines take a negative value for d -dimers for a sufficient method to rule out aortic dissection in patients with a low clinical probability, as calculated by the ADD risk score. We present two cases of patients with acute aortic dissection, albeit presenting with a low clinical probability for acute aortic dissection and negative values for d -dimers. < Learning objective: One must entertain a high level of suspicion for acute aortic syndrome as even laboratory results within the normal range of d -dimers connected with a low clinical probability can be misleading. According to the patient's symptoms, a battery of different diagnostic tools should play in concert, including imaging studies, repeat clinical evaluation, and repeat laboratory tests, such as d -dimers, before dismissing a diagnosis as severe as aortic dissection.> [ABSTRACT FROM AUTHOR]

Published
2017
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243. Impaired Function of Inhibitory G Proteins During Acute Myocardial Ischemia of Canine Hearts and Its Reversal During Reperfusion and a Second Period of Ischemia

Author

Niroomand, Feraydoon, primary, Weinbrenner, Christof, additional, Weis, Angelika, additional, Bangert, Matthias, additional, Schwencke, Carsten, additional, Marquetant, Rainer, additional, Beyer, Thorsten, additional, Strasser, Ruth H., additional, Kübler, Wolfgang, additional, and Rauch, Bernhard, additional

Published
1995
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244. In Situ Postconditioning With Neuregulin-1β Is Mediated by a PI3K/Akt-Dependent Pathway

Author

Ebner, Bernd, Lange, Stefan A., Hollenbach, Doreen, Steinbronn, Nadine, Ebner, Annette, Fischaleck, Clementine, Braun-Dullaeus, Rüdiger, Weinbrenner, Christof, and Strasser, Ruth H.

Abstract

The myocardial infarct size can be reduced by pharmacological postconditioning using cardioprotective agents. Neuregulin-1β is a potential candidate, but previous studies in an isolated heart model of ischemia and reperfusion displayed controversial results. An in situ model of ischemia/reperfusion was used to clarify whether the remote application of neuregulin-1β can reduce the reperfusion injury. A second aim was to evaluate, if the effects are specific for reperfused tissue or if this is a general antiapoptotic effect. In addition, the contributing molecular mechanisms were investigated.

Published
2015
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245. The lysosomal transfer of LDL/cholesterol from macrophages into vascular smooth muscle cells induces their phenotypic alteration.

Author

Weinert, Sönke, Poitz, David M., Auffermann-Gretzinger, Susanne, Eger, Lars, Herold, Joerg, Medunjanin, Senad, Schmeisser, Alexander, Strasser, Ruth H., and Braun-Dullaeus, Ruediger C.

Subjects
LYSOSOMES, LOW density lipoproteins, MACROPHAGES, VASCULAR smooth muscle, PHENOTYPES, MUSCLE cells, ATHEROSCLEROTIC plaque
Abstract

Aims Macrophages (MPs) and vascular smooth muscle cells (VSMCs) closely interact within the growing atherosclerotic plaque. An in vitro co-culture model was established to study how MPs modulate VSMC behaviour. Methods and results MPs were exposed to fluorescence-labelled-acetylated LDL (FL-acLDL) prior to co-culture with VSMCs. Fluorescence microscopy visualized first transport of FL-acLDL within 6 h after co-culture implementation. When MPs had been fed with FL-acLDL in complex with fluorescence-labelled cholesterol (FL-Chol), these complexes were also transferred during co-culture and resulted in cholesterol positive lipid droplet formation in VSMCs. When infected with a virus coding for a fusion protein of Rab5a and fluorescent protein reporter (FP) to mark early endosomes, no co-localization between Rab5a-FP and the transported FL-acLDL within VSMCs was detected implying a mechanism independent of phagocytosis. Next, expression of lysosome-associated membrane glycoprotein 1 (LAMP1)-FP, marking all lysosomes in VSMCs, revealed that the FL-acLDL was located in non-acidic lysosomes. MPs infected with virus encoding for LAMP1-FP prior to co-culture demonstrated that intact fluorescence-marked lysosomes were transported into the VSMC, instead. Xenogenic cell composition (rat VSMC, human MP) and subsequent quantitative RT–PCR with rat-specific primers rendered induction of genes typical for MPs and down-regulation of the cholesterol sensitive HMG-CoA reductase. Conclusion Our results demonstrate that acLDL/cholesterol-loaded lysosomes are transported from MPs into VSMCs in vitro. Lysosomal transfer results in a phenotypic alteration of the VSMC towards a foam cell-like cell. This way VSMCs may lose their plaque stabilizing properties and rather contribute to plaque destabilization and rupture. [ABSTRACT FROM AUTHOR]

Published
2013
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250. Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: Design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial.

Author

Thiele, Holger, Schuler, Gerhard, Neumann, Franz-Josef, Hausleiter, Jörg, Olbrich, Hans-Georg, Schwarz, Bettina, Hennersdorf, Marcus, Empen, Klaus, Fuernau, Georg, Desch, Steffen, de Waha, Suzanne, Eitel, Ingo, Hambrecht, Rainer, Böhm, Michael, Kurowski, Volkhard, Lauer, Bernward, Minden, Hans-Heinrich, Figulla, Hans-Reiner, Braun-Dullaeus, Rüdiger C., and Strasser, Ruth H.

Abstract

Background: In current guidelines, intraaortic balloon pumping (IABP) is considered a class 1 indication in cardiogenic shock complicating acute myocardial infarction. However, evidence is mainly based on retrospective or prospective registries with a lack of randomized clinical trials. Therefore, IABP is currently only used in 20% to 40% of cardiogenic shock cases. The hypothesis of this trial is that IABP in addition to early revascularization by either percutaneous coronary intervention or coronary artery bypass grafting will improve clinical outcome of patients in cardiogenic shock. Study Design: The IABP-SHOCK II study is a 600-patient, prospective, multicenter, randomized, open-label, controlled trial. The study is designed to compare the efficacy and safety of IABP versus optimal medical therapy on the background of early revascularization by either percutaneous coronary intervention or coronary artery bypass grafting. Patients will be randomized in a 1:1 fashion to 1 of the 2 treatments. The primary efficacy end point of IABP-SHOCK II is 30-day all-cause mortality. Secondary outcome measures, such as hemodynamic, laboratory, and clinical parameters, will serve as surrogate end points for prognosis. Furthermore, an intermediate and long-term follow-up at 6 and 12 months will be performed. Safety will be assessed, by the GUSTO bleeding definition, peripheral ischemic complications, sepsis, and stroke. Conclusions: The IABP-SHOCK II trial addresses important questions regarding the efficacy and safety of IABP in addition to early revascularization in patients with cardiogenic shock complicating myocardial infarction. [Copyright &y& Elsevier]

Published
2012
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