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204. Induction Therapy With Alemtuzumab (Campath) in Combined Liver-Kidney Transplantation: University of Bologna Experience

Author

Gaudio, M. Del, primary, Ravaioli, M., additional, Ercolani, G., additional, Cescon, M., additional, Amaduzzi, A., additional, Neri, F., additional, Pellegrini, S., additional, Feliciangeli, G., additional, LaManna, G., additional, Morelli, C., additional, D'Arcangelo, G. Liviano, additional, Comai, G., additional, Cucchi, M., additional, Stefoni, S., additional, and Pinna, A.D., additional

Published
2013
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205. Transplantation: basic science

Author

Cantaluppi, V., primary, De Lena, M., additional, Beltramo, S., additional, Ferrario, S., additional, Dellepiane, S., additional, Figliolini, F., additional, Bruno, S., additional, Biancone, L., additional, Segoloni, G. P., additional, Tetta, C., additional, Camussi, G., additional, Prasad, N., additional, Jaisawal, A., additional, Yadav, B., additional, Agarwal, V., additional, Tripathi, D., additional, Nunez-Lozano, R., additional, Quiros, Y., additional, Sanchez-Gonzalez, P., additional, Perez de Obanos, M. P., additional, Ruiz, J., additional, Lopez-Hernandez, F. J., additional, Lopez-Novoa, J. M., additional, Yang, J. W., additional, Kim, J. S., additional, Lee, J. Y., additional, Park, H. C., additional, Han, B. G., additional, Choi, S. O., additional, Matsuyama, M., additional, Yoshimura, R., additional, Hayama, T., additional, Chargui, J., additional, Touraine, J.-L., additional, Yoshimura, N., additional, Zanazzi, M., additional, Carta, P., additional, Caroti, L., additional, Antognoli, G., additional, Pinzani, P., additional, Salvianti, F., additional, Villari, D., additional, Minetti, E., additional, Genina, A., additional, Ismail, W., additional, Soliman, A., additional, Ucar, H., additional, Akbas, H. S., additional, Yilmaz, V. T., additional, Aktas, A., additional, Suleymanlar, G., additional, Yucel, G., additional, Cappuccilli, M. L., additional, La Manna, G., additional, Capelli, I., additional, Baraldi, O., additional, Cuna, V., additional, Battaglino, G., additional, Todeschini, P., additional, Feliciangeli, G., additional, Scolari, M. P., additional, Stefoni, S., additional, Loiacono, E., additional, Votta, B., additional, Amore, A., additional, Ranghino, A., additional, Camilla, R., additional, Peruzzi, L., additional, Donadio, M. E., additional, Serriello, I., additional, Gallo, R., additional, Puccinelli, M. P., additional, Coppo, R., additional, Sahin, G., additional, Meltem Akay, O., additional, Uslu, S., additional, Bal, C., additional, Ugur Yalcin, A., additional, Gulbas, Z., additional, and George, J., additional

Published
2013
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206. Vascular access

Author

McCullough, K. P., primary, Lok, C. E., additional, Fluck, R. J., additional, Spergel, L. M., additional, Andreucci, V. E., additional, Fort, J., additional, Krishnan, M., additional, Fissell, R. B., additional, Kawanishi, H., additional, Saran, R., additional, Port, F. K., additional, Robinson, B. M., additional, Pisoni, R. L., additional, Shinzato, T., additional, Shionoya, Y., additional, Fukui, H., additional, Sasaki, M., additional, Miwa, M., additional, Toma, S., additional, Lin, C.-C., additional, Yang, W.-C., additional, Simone, S., additional, Loverre, A., additional, Cariello, M., additional, Divella, C., additional, Castellano, G., additional, Gesualdo, L., additional, Grandaliano, G., additional, Pertosa, G., additional, Mattei, S., additional, Pignatelli, G., additional, Corradini, M., additional, Stefani, A., additional, Bovino, A., additional, Iannuzzella, F., additional, Vaglio, A., additional, Manari, A., additional, Pasquali, S., additional, Chan, J.-S., additional, Wu, T.-C., additional, Roy-Chaudhury, P., additional, Shih, C.-C., additional, Chen, J.-W., additional, Ponce, P., additional, Scholz, C., additional, Goncalves, P., additional, Grassmann, A., additional, Canaud, B., additional, Marcelli, D., additional, Suzuki, S., additional, Shibata, K., additional, Kuji, T., additional, Kawata, S., additional, Koguchi, N., additional, Nishihara, M., additional, Satta, H., additional, Toya, Y., additional, Umemura, S., additional, Corbett, R., additional, Demicheli, N., additional, Iori, F., additional, Grechy, L., additional, Khiroya, R., additional, Ellis, D., additional, Crane, J., additional, Hamady, M., additional, Gedroyc, W., additional, Duncan, N., additional, Vincent, P., additional, Caro, C., additional, Sarween, N., additional, Price, A., additional, Powers, S., additional, Allen, C., additional, Holland, M., additional, Gupta, I., additional, Baharani, J., additional, Parisotto, M. T., additional, Schoder, V., additional, Kaufmann, P., additional, Miriunis, C., additional, Moura, A., additional, Madureira, J., additional, Alija, P., additional, Fernandes, J., additional, Oliveira, J. G., additional, Lopez, M., additional, Felgueiras, M., additional, Amado, L., additional, Sameiro-Faria, M., additional, Miranda, V., additional, Vieira, M., additional, Santos-Silva, A., additional, Costa, E., additional, David, P., additional, Capurro, F., additional, Brustia, M., additional, De Mauri, A., additional, Ruva, C., additional, Chiarinotti, D., additional, Gravellone, L., additional, De Leo, M., additional, Turkvatan, A., additional, Kirkpantur, A., additional, Mandiroglu, S., additional, Afsar, B., additional, Seloglu, B., additional, Alkis, M., additional, Erkula, S., additional, GURBUZ, H. G., additional, Serin, M., additional, CALIK, Y., additional, Mandiroglu, F., additional, Balci, M., additional, Rikker, C., additional, Juhasz, E., additional, Tornoci, L., additional, Tovarosi, S., additional, Greguschik, J., additional, Rosivall, L., additional, Ibeas, J., additional, Valeriano, J., additional, Vallespin, J., additional, Fortuno, J., additional, Rodriguez-Jornet, A., additional, Cabre, C., additional, Merino, J., additional, Vinuesa, X., additional, Bolos, M., additional, Branera, J., additional, Mateos, A., additional, Jimeno, V., additional, Grau, C., additional, Criado, E., additional, Moya, C., additional, Ramirez, J., additional, Gimenez, A., additional, Garcia, M., additional, Kirmizis, D., additional, Kougioumtzidou, O., additional, Vakianis, P., additional, Bandera, A., additional, Veniero, P., additional, Brunori, G., additional, Dimitrijevic, Z., additional, Cvetkovic, T., additional, Paunovic, K., additional, Stojanovic, M., additional, Ljubenovic, S., additional, Mitic, B., additional, Djordjevic, V., additional, Aicha Henriette, S., additional, Farideh, A., additional, Daniela, B., additional, Zafer, T., additional, Francois, C., additional, Donati, G., additional, Scrivo, A., additional, Cianciolo, G., additional, La Manna, G., additional, Panicali, L., additional, Rucci, P., additional, Marchetti, A., additional, Giampalma, E., additional, Galaverni, M., additional, Golfieri, R., additional, Stefoni, S., additional, Skornyakov, I., additional, Kiselev, N., additional, Rozhdestvenskaya, A., additional, Stolyar, A., additional, Ancarani, P. P. A., additional, Devoto, E., additional, Dardano, G. G. D., additional, Coskun yavuz, Y., additional, Selcuk, N. Y., additional, Guney, I., additional, Altintepe, L., additional, Gerasimovska, V., additional, Gerasimovska-Kitanovska, B., additional, Persic, V., additional, Buturovic-Ponikvar, J., additional, Arnol, M., additional, Ponikvar, R., additional, Conti, N., additional, Scrivano, J., additional, Pettorini, L., additional, Giuliani, A., additional, Punzo, G., additional, Mene, P., additional, Pirozzi, N., additional, Kocyigit, I., additional, Unal, A., additional, Guney, A., additional, Mavili, E., additional, Deniz, K., additional, Sipahioglu, M., additional, Eroglu, E., additional, Tokgoz, B., additional, Oymak, O., additional, Gunal, A., additional, Boubaker, K., additional, Kaaroud, H., additional, Kheder, A., additional, Vidal, M., additional, Amengual, M. J., additional, Orellana, R., additional, Sanfeliu, I., additional, Marquina, D., additional, Xirinachs, M., additional, Sanchez, E., additional, Rey, M., additional, Strozecki, P., additional, Flisinski, M., additional, Kapala, A., additional, Manitius, J., additional, Gerasimovska-Kitanovska, B. D., additional, Sikole, A., additional, Weber, E., additional, Adrych, D., additional, Wolyniec, W., additional, Liberek, T., additional, Rutkowski, B., additional, Oguchi, K., additional, Nakahara, T., additional, Okamoto, M., additional, Iwabuchi, H., additional, Asano, M., additional, Rap, O., additional, Ruiz-Valverde, M., additional, Rodriguez-Murillo, J. A., additional, Mallafre-Anduig, J. M., additional, Zeid, M. M., additional, Deghady, A. A., additional, Elshair, H. S., additional, Elkholy, N. A., additional, Panagoutsos, S., additional, Devetzis, V., additional, Roumeliotis, A., additional, Kantartzi, K., additional, Mourvati, E., additional, Vargemezis, V., additional, Passadakis, P., additional, Kang, S. H., additional, Jung, S. Y., additional, Lee, S. H., additional, Cho, K. H., additional, Park, J. W., additional, Yoon, K. W., additional, and Do, J. Y., additional

Published
2013
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207. Alternative Vascular Access for Hemodialysis

Author

Mosconi, G, Zanchelli, F, Colì, L, Pace, G, Perna, C, Donati, G, Dalmastri, V, Gargiulo, M, Freyrie, A, and Stefoni, S

Subjects
Hemodialysis, vascular access, PTFE grafts
Published
1997

209. Effect of different dialysis membranes on platelet function. A tool for biocompatibility evaluation

Author

Lb, Sanctis, Stefoni S, Cianciolo G, Colì L, Andrea Buscaroli, Feliciangeli G, Lc, Borgnino, Bonetti M, Mc, Gregorini, De Giovanni P, and Buttazzi R

Subjects
Adult, Blood Platelets, Male, Serotonin, alpha-2-Antiplasmin, Heparin, Platelet Count, Polymers, Thrombin Time, Antithrombin III, Fibrinogen, Biocompatible Materials, Membranes, Artificial, Plasminogen, Middle Aged, Platelet Factor 4, beta-Thromboglobulin, Renal Dialysis, Humans, Female, Partial Thromboplastin Time, Sulfones, Cellulose, Cell Size
Abstract

Intradialytic coagulative and platelet activation, one of the main consequences of blood-membrane contact, was studied in a group of 5 RDT patients with a comparative evaluation of 3 different dialytic membranes: Cuprophan (CU), Polysulfone (PS) and Cellulose Triacetate (CT). Each patient underwent 5 consecutive dialysis sessions with the above mentioned membranes. Intradialytic platelet activation was studied through a morpho-functional evaluation between the mean platelet volume (MPV) and Serotonin (S), beta-Thromboglobulin (beta-TG) and Platelet Factor 4 (PF4) serum levels. These determinations were made before HD (time 0) and after 30', 120', and 240'. We also checked the intradialytic status of thrombogenesis and fibrinolysis determining aPTT, thrombin time, fibrinogen, antithrombin III (AT III), alpha-2 antiplasmin and plasminogen, at the same time intervals. All membranes tested (CU, PS, CT) caused appreciable intradialytic platelet activation, above all after 15' and at the end of dialysis sessions, more marked for CU than PS or CT. In particular MPV showed a decrease throughout the session (-5% at 30' and -9% at 240') while S, beta TG and PF4 peripheral blood levels showed a significant increase at the same intervals with CU membrane. Lastly coagulative and fibrinolytic parameters showed no significant differences among any of the membranes tested.

Published
1996

210. Effect of a plasma sodium biofeedback system applied to HFR on the intradialytic cardiovascular stability. Results from a randomized controlled study

Author

Locatelli, F., primary, Stefoni, S., additional, Petitclerc, T., additional, Coli, L., additional, Di Filippo, S., additional, Andrulli, S., additional, Fumeron, C., additional, Frasca, G. M., additional, Sagripanti, S., additional, Savoldi, S., additional, Serra, A., additional, Stallone, C., additional, Aucella, F., additional, Gesuete, A., additional, Scarlatella, A., additional, Quarello, F., additional, Mesiano, P., additional, Ahrenholz, P., additional, Winkler, R., additional, Mandart, L., additional, Fort, J., additional, Tielemans, C., additional, and Navino, C., additional

Published
2012
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211. Bone and mineral diseases - 1

Author

Walter*, S., primary, Dong, J., additional, Alexander, S., additional, Hunter, T., additional, Yin, K., additional, Maclean, D., additional, Tomlinson, J., additional, Karim, F., additional, Johnson, R., additional, Stevens, K., additional, Patel, R., additional, Clancy, M., additional, Graham, D., additional, Delles, C., additional, Jardine, A., additional, Behets, G., additional, Viaene, L., additional, Meijers, B., additional, D'haese, P., additional, Evenepoel, P., additional, Seiler, S., additional, Herath, E., additional, Flugge, F., additional, Weihrauch, A., additional, Fliser, D., additional, Heine, G. H., additional, Brandenburg, V., additional, Kruger, T., additional, Wagstaff, R., additional, Floege, J., additional, Specht, P., additional, Ketteler, M., additional, Angelini, M. L., additional, Cianciolo, G., additional, La Manna, G., additional, Cappuccilli, M. L., additional, Della Bella, E., additional, Rum, I., additional, Conte, D., additional, Cuna, V., additional, Dormi, A., additional, Todeschini, P., additional, Donati, G., additional, Costa, R., additional, Bagnara, G. P., additional, and Stefoni, S., additional

Published
2012
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212. Transplantation - clinical II

Author

Riegersperger, M., primary, Plischke, M., additional, Steiner-Boker, S., additional, Seidinger, D., additional, Winkelmayer, W., additional, Sunder-Plassmann, G., additional, Vlahovic, P., additional, Cvetkovic, T., additional, Djordjevic, V., additional, Velickovic-Radovanovic, R., additional, Stefanovic, N., additional, Ignjatovic, A., additional, Sladojevic, N., additional, Cademartori, V., additional, Massarino, F., additional, Parodi, E. L., additional, Russo, R., additional, Sofia, A., additional, Fontana, I., additional, Viviani, G. L., additional, Garibotto, G., additional, Mai, M., additional, Mai, W., additional, Taner, B., additional, Wadei, H., additional, Prendergast, M., additional, Gonwa, T., additional, Martin, J., additional, Aurore, S., additional, Aline, C. S., additional, Nicolas, M., additional, Manolie, M., additional, Catherine, S., additional, Eric, A., additional, Christophe, M., additional, Brakemeier, S., additional, Liefeldt, L., additional, Glander, P., additional, Waiser, J., additional, Lachmann, N., additional, Schonemann, C., additional, Zukunft, B., additional, Illigens, P., additional, Schmidt, D., additional, Wu, K., additional, Rudolph, B., additional, Neumayer, H.-H., additional, Budde, K., additional, Pallardo Mateu, L., additional, Gavela Martinez, E., additional, Sancho Calabuig, A., additional, Crespo Albiach, J., additional, Beltran Catalan, S., additional, Kanter Berga, J., additional, Kimura, T., additional, Yagisawa, T., additional, Ishikawa, N., additional, Sakuma, Y., additional, Hujiwara, T., additional, Nukui, A., additional, Yashi, M., additional, Duraes, J., additional, Malheiro, J., additional, Fonseca, I., additional, Rocha, A., additional, Martins, L. S., additional, Almeida, M., additional, Dias, L., additional, Castro-Henriques, A., additional, Cabrita, A., additional, Volpe, A., additional, Quaglia, M., additional, Menegotto, A., additional, Fenoglio, R., additional, Izzo, C., additional, Airoldi, A., additional, Terrone, C., additional, Stratta, P., additional, Ahmed, B., additional, Mireille, K., additional, Nilufer, B., additional, Annick, M., additional, Karl Martin, W., additional, Anh-Dung, H., additional, Dimitri, M., additional, Philippe, M., additional, Judith, R., additional, Daniel, A., additional, Lan, Y., additional, Heine, C., additional, Capone, V., additional, Grace, B., additional, Clayton, P., additional, Cass, A., additional, Mcdonald, S., additional, Fujiwara, T., additional, Iwabuchi, T., additional, Muraishi, O., additional, Torregrosa, V., additional, Barros, X., additional, Martinez de Osaba, M. J., additional, Paschoalin, R., additional, Campistol, J. M., additional, Hassan, R., additional, El-Hefnawy, A., additional, Soliman, S., additional, Shokeir, A., additional, Cobanoglu Kudu, A., additional, Gungor, O., additional, Kircelli, F., additional, Altinel, E., additional, Asci, G., additional, Ozbek, S. S., additional, Toz, H., additional, Ok, E., additional, Sandrini, S., additional, Setti, G., additional, Valerio, F., additional, Possenti, S., additional, Torrisi, I., additional, Polanco, N., additional, Garcia-Puente, L., additional, Gonzalez Monte, E., additional, Morales, E., additional, Gutierrez, E., additional, Bengoa, I., additional, Hernandez, A., additional, Caballero, J., additional, Morales, J. M., additional, Andres, A., additional, Sgarlato, V., additional, Comai, G., additional, La Manna, G., additional, Moretti, I., additional, Grandinetti, V., additional, Martelli, D., additional, Scolari, M. P., additional, Stefoni, S., additional, Valentini, C., additional, Persici, E., additional, Cappuccilli, M. L., additional, Liviano D'arcangelo, G., additional, Fabbrizio, B., additional, Carretta, E., additional, Mosconi, G., additional, Feliciangeli, G., additional, Grigioni, F. W., additional, Apicella, L., additional, Guida, B., additional, Vitale, S., additional, Garofalo, G., additional, Russo, L., additional, Maresca, I., additional, Rossano, R., additional, Memoli, B., additional, Carrano, R., additional, Federico, S., additional, Sabbatini, M., additional, Carta, P., additional, Zanazzi, M., additional, DI Maria, L., additional, Caroti, L., additional, Miejshtri, A., additional, Tsalouchos, A., additional, Bertoni, E., additional, Sezer, S., additional, Erkmen Uyar, M., additional, Colak, T., additional, Bal, Z., additional, Tutal, E., additional, Kalaci, G., additional, Ozdemir Acar, F. N., additional, Jacquelinet, C., additional, Bayat, S., additional, Pernin, V., additional, Portales, P., additional, Szwarc, I., additional, Garrigue, V., additional, Vetromile, F., additional, Delmas, S., additional, Eliaou, J. F., additional, Mourad, G., additional, Huber, L., additional, Slowinski, T., additional, Naik, M., additional, Nakai, K., additional, Fujii, H., additional, Kono, K., additional, Goto, S., additional, Ishimura, T., additional, Takeda, M., additional, Fujisawa, M., additional, Nishi, S., additional, Pereira Paschoalin, R., additional, Torregrosa, J. V., additional, Barros Freiria, X., additional, Duran Rebolledo, C. E., additional, Sanchez Escuredo, A., additional, Sole, M., additional, Youssouf, S., additional, Tabbasm, F., additional, Bell, R., additional, Al-Jayyousi, R., additional, Warwick, G., additional, Grall, A., additional, Treguer, L., additional, Essig, M., additional, Lecaque, C., additional, Noel, N., additional, Buchler, M., additional, Bertrand, D., additional, Rivalan, J., additional, Braun, L., additional, Villemain, F., additional, Hurault de Ligny, B., additional, Totet, A., additional, Pestourie, N., additional, Toubas, D., additional, Nevez, G., additional, Le Meur, Y., additional, Nour el Houda, B., additional, Mustapha, H., additional, Wafaa, F., additional, Inass, L., additional, Rambabova Bushljetikj, I., additional, Masin-Spasovska, J., additional, Spasovski, G., additional, Popov, Z., additional, Sikole, A., additional, Ivanovski, N., additional, Raimundo, M., additional, Guerra, J., additional, Teixeira, C., additional, Santana, A., additional, Silva, S., additional, Mil Homens, C., additional, Gomes Da Costa, A., additional, Loredo, D., additional, Cleres, M., additional, Gondolesi, G., additional, Gutierrez, L. M., additional, Fortunato, R. M., additional, Descalzi, V., additional, and Raffaele, P., additional

Published
2012
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216. Analysis of 80 Dual-Kidney Transplantations: A Multicenter Experience

Author

Nardo, B., primary, Bertelli, R., additional, Cavallari, G., additional, Capocasale, E., additional, Cappelli, G., additional, Mazzoni, M.P., additional, Benozzi, L., additional, Valle, R. Dalla, additional, Fuga, G., additional, Busi, N., additional, Gilioli, C., additional, Albertazzi, A., additional, Stefoni, S., additional, Pinna, A.D., additional, and Faenza, A., additional

Published
2011
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220. Restless legs syndrome enhances cardiovascular risk and mortality in patients with end-stage kidney disease undergoing long-term haemodialysis treatment

Author

La Manna, G., primary, Pizza, F., additional, Persici, E., additional, Baraldi, O., additional, Comai, G., additional, Cappuccilli, M. L., additional, Centofanti, F., additional, Carretta, E., additional, Plazzi, G., additional, Coli, L., additional, Montagna, P., additional, and Stefoni, S., additional

Published
2010
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224. SAFETY PROFILE OF TASOCITINIB (CP-690,550)-BASED CNI-FREE REGIMENS IN DE NOVO KIDNEY TRANSPLANT PATIENTS IN A DOSE/EXPOSURE-FINDING PHASE 2B STUDY: RESULTS OF A 6-MONTH INTERIM ANALYSIS

Author

Tedesco-Silva, H., primary, Grinyó, J. M., additional, Brennan, D., additional, Klintmalm, G., additional, Hartmann, A., additional, Kulkarni, S., additional, Vincenti, F., additional, Steinberg, S., additional, Stefoni, S., additional, Kudlacz, E., additional, and Chan, G., additional

Published
2010
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237. Value of panel reactive antibodies (PRA) as a guide to the treatment of hyperimmunized patients in renal transplantation

Author

Andrea Buscaroli, Nanni Costa A, Iannelli S, Cianciolo G, De Santis L, La Manna G, Stefoni S, Vangelista A, and Bonomini V

Subjects
Adult, Cytotoxicity, Immunologic, Male, Reoperation, Time Factors, Adolescent, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Isoantibodies, Predictive Value of Tests, Renal Dialysis, Humans, Blood Transfusion, Child, Antilymphocyte Serum, Retrospective Studies, Transplantation, Histocompatibility Testing, Graft Survival, Infant, Middle Aged, Kidney Transplantation, Child, Preschool, 030211 gastroenterology & hepatology, Female, Immunosuppressive Agents, Follow-Up Studies
Abstract

Patient presensitization represents a considerable problem in candidacy for renal transplantation. While it is well known that hyperimmunized patients--panel reactive antibody (PRA) higher than 60%--create difficulties in donor matching and have a worse outcome than non-hyperimmunized patients, less information is available on patients with an intermediate degree of sensitization (30-60%). In order to evaluate how graft outcome relates to such degrees of sensitization, 241 consecutive transplanted patients were divided into two groups on the basis of their previous year's PRA peak: group A, PRA 0-29%; group B, PRA 30-60%. Group A showed a significantly better survival both in the first year (90% vs 79%, P0.05) and in the third year (82% vs 64%, P0.01). However, detailed analysis of group B demonstrated that some parameters may significantly influence graft outcome: (1) better compatibility on locus DR; (2) a primary kidney transplant; (3) a dialysis duration of less than 6 months; and (4) the prophylactic use of antilymphocyte globulin (ALG).

Published
1992

238. Flow cytometry evaluation of urinary sediment in renal transplantation

Author

Nanni-Costa A, Iannelli S, Vangelista A, Andrea Buscaroli, Liviano G, Raimondi C, Todeschini P, Lamanna G, Stefoni S, and Bonomini V

Subjects
Transplantation, 030230 surgery, Urine, Flow Cytometry, Kidney Transplantation, Killer Cells, Natural, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Antigens, CD, Reference Values, Humans, 030211 gastroenterology & hepatology, Lymphocytes
Abstract

The value of exfoliative urinary cytology for the diagnosis of different pathological conditions in renal transplantation is widely recognized. The method, however, has not yet gained full acceptance, mainly because identification of the different cells is not always possible by means of standard staining techniques. In view of its characteristics, flow cytometry (FC) seems to represent a consistently reliable, rapid and innovative approach for differentialing the various cells present in the urinary sediment and assessing their number. This study gives the examination result of 223 urinary specimens from 127 transplanted patients selected according to pathology. Sediment cells, collected from fresh urine samples, were washed, treated with a lysing solution, resuspended in saline solution and directly analysed in a FACSCAN cytometer. Morphological evaluation showed: a small number of cells in patients with stable renal function; a larger number of cells, with predominance of lymphocytes, during acute rejection episodes; an absolute predominance of neutrophils during bacterial infection; large-sized cellular debris in cases of post-transplant tubular necrosis; and small cell debris in cases of cyclosporine cytotoxicity. Lymphocyte surface-marker evaluation made it possible to differentiate lymphocyte populations observed during acute rejection episodes (cytotoxic T-cell, CD8 and HLA class II and NK cells) from those detected during bacterial infection (T-cell CD4 positive). These results suggest that urinary FC may be a reliable diagnostic tool in clinical renal transplantation.

Published
1992

245. GENETIC FACTORS IN CHRONIC ALLOGRAFT NEPHROPATHY. A CASE-CONTROL STUDY IN A POPULATION OF KIDNEY TRANSPLANTED PATIENTS

Author

Scolari, M P., primary, La Manna, G, additional, Cappuccilli, M L., additional, Lanci, N, additional, Todeschini, P, additional, Dormi, A, additional, Conte, D, additional, Borgnino, L C., additional, Chiarini, A, additional, D’Addio, F, additional, D’Arcangelo, G Liviano, additional, Feliciangeli, G, additional, Faenza, A, additional, and Stefoni, S, additional

Published
2004
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