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1,362 results on '"Stefan, Norbert"'

201. The TUDID Study – Background and Design of a Prospective Cohort.

Author

Jaghutriz, Benjamin Assad, Wagner, Robert, Kullmann, Stephanie, Fritsche, Louise, Eckstein, Sabine S., Dannecker, Corinna, Willmann, Caroline, Randrianarisoa, Elko, Lehn-Stefan, Angela, Hieronimus, Anja, Hudak, Sarah, Vosseler, Dorothea, Lamprinou, Apostolia, Huber, Philipp, Vosseler, Andreas, Willmann, Gabriel, Heyne, Nils, Wolff, Diana, Stefan, Norbert, and Häring, Hans-Ulrich

Subjects
TYPE 1 diabetes, DIABETES complications, TYPE 2 diabetes, DIABETES
Abstract

Prevalence of both type 1 and type 2 diabetes mellitus is growing worldwide and one major cause for morbidity and mortality. However, not every patient develops diabetes-related complications, but causes for the individual susceptibility are still not fully understood. As a platform to address this, we initiated the TUDID (TUebingen DIabetes Database) study, a prospective, monocentric, observational study that includes adults with diabetes mellitus who are treated in the inpatient clinic of a University Hospital in southern Germany. Besides a thorough clinical examination and extensive laboratory tests (with integrated biobanking), major study focuses are the kidneys, the eyes, the vasculature as well as cognition and mood where standardized investigations for early stages for diabetes complications are performed. Analyses of the data generated by this precise characterization of diabetes-related complications will contribute to our understanding of the development and course of such complications, and thus facilitate the implementation of tailored treatment options that can reduce the risk and severity of diabetes-related complications. [ABSTRACT FROM AUTHOR]

Published
2022
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208. Single-Nucleotide Polymorphism rs7754840 of CDKAL1 Is Associated with Impaired Insulin Secretion in Nondiabetic Offspring of Type 2 Diabetic Subjects and in a Large Sample of Men with Normal Glucose Tolerance

Author

Stančáková, Alena, Pihlajamäki, Jussi, Kuusisto, Johanna, Stefan, Norbert, Fritsche, Andreas, Häring, Hans, Andreozzi, Francesco, Succurro, Elena, Sesti, Giorgio, Boesgaard, Trine Welløv, Hansen, Torben, Pedersen, Oluf, Jansson, Per Anders, Hammarstedt, Ann, Smith, Ulf, and Laakso, Markku

Published
2008

213. Associations of short stature and components of height with incidence of type 2 diabetes

Author

Wittenbecher, Clemens (Dr.), Kuxhaus, Olga, Boeing, Heiner, Stefan, Norbert (Dr. med.), and Schulze, Matthias Bernd (Prof. Dr.)

Subjects
ddc:570, Institut für Ernährungswissenschaft
Abstract

Aims/hypothesis This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. Methods A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. Results After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among men and women, but only among men if adjusted for total height. Adjustment for liver fat and triacylglycerols, adiponectin and C-reactive protein substantially attenuated associations between height and diabetes risk, particularly among women. Conclusions/interpretation We observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile.

Published
2019

214. Potential effects of reduced red meat compared with increased fiber intake on glucose metabolism and liver fat content

Author

Willmann, Caroline, Heni, Martin, Linder, Katarzyna, Wagner, Robert, Stefan, Norbert, Machann, Jürgen, Schulze, Matthias Bernd (Prof. Dr.), Joost, Hans-Georg, Haring, Hans-Ulrich, and Fritsche, Andreas

Subjects
Institut für Ernährungswissenschaft, ddc:610
Abstract

Background: Epidemiological studies suggest that an increased red meat intake is associated with a higher risk of type 2 diabetes, whereas an increased fiber intake is associated with a lower risk. Objectives: We conducted an intervention study to investigate the effects of these nutritional factors on glucose and lipid metabolism, body-fat distribution, and liver fat content in subjects at increased risk of type 2 diabetes. Methods: This prospective, randomized, and controlled dietary intervention study was performed over 6 mo. All groups decreased their daily caloric intake by 400 kcal. The "control" group (N = 40) only had this requirement. The "no red meat" group (N = 48) in addition aimed to avoid the intake of red meat, and the "fiber" group (N = 44) increased intake of fibers to 40 g/d. Anthropometric parameters and frequently sampled oral glucose tolerance tests were performed before and after intervention. Body-fat mass and distribution, liver fat, and liver iron content were assessed by MRI and single voxel proton magnetic resonance spectroscopy. Results: Participants in all groups lost weight (mean 3.3 +/- 0.5 kg, P < 0.0001). Glucose tolerance and insulin sensitivity improved (P < 0.001), and body and visceral fat mass decreased in all groups (P < 0.001). These changes did not differ between groups. Liver fat content decreased significantly (P < 0.001) with no differences between the groups. The decrease in liver fat correlated with the decrease in ferritin during intervention (r(2) = 0.08, P = 0.0021). This association was confirmed in an independent lifestyle intervention study (Tuebingen Lifestyle Intervention Program, N = 229, P = 0.0084). Conclusions: Our data indicate that caloric restriction leads to a marked improvement in glucose metabolism and body-fat composition, including liver-fat content. The marked reduction in liver fat might be mediated via changes in ferritin levels. In the context of caloric restriction, there seems to be no additional beneficial impact of reduced red meat intake and increased fiber intake on the improvement in cardiometabolic risk parameters. This trial was registered at clinicaltrials.gov as NCT03231839.

Published
2019

215. MOESM1 of Effect of SGLT2 inhibitors on body composition, fluid status and renin–angiotensin–aldosterone system in type 2 diabetes: a prospective study using bioimpedance spectroscopy

Author

Schork, Anja, Saynisch, Janine, Vosseler, Andreas, Jaghutriz, Benjamin, Heyne, Nils, Peter, Andreas, Hans-Ulrich Häring, Stefan, Norbert, Fritsche, Andreas, and Artunc, Ferruh

Abstract

Additional file 1: Figure S1. Course of HbA1c (A), BMI (B), fat tissue index (FTI, C), lean tissue index (LTI, D), total body water (E), intracellular water (F), systolic and diastolic blood pressure (G and H) and heart rate (I) under treatment with SGLT2 inhibitors. Left side shows absolute values, right side shows values normalized for baseline value. Whiskers indicate median and interquartile range. Friedman test was performed to test for significant differences during course of follow up; Wilcoxon Signed-Rank test was used to evaluate for differences between respective points of follow up; Bonferroni correction for multiple testing was performed.

Published
2019
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230. Heremans-Schmid glycoprotein/ fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans

Author

Stefan, Norbert, Hennige, Anita M., Staiger, Harald, Machann, Jurgen, Schick, Fritz, Krober, Stefan M., Machicao, Fausto, Fritsche, Andreas, and Haring, Hans-Ulrich

Subjects
Diabetes -- Research, Insulin resistance -- Risk factors -- Research, Alpha fetoproteins -- Research, Type 2 diabetes -- Causes of -- Research -- Risk factors, Health, Research, Risk factors, Causes of
Abstract

OBJECTIVE--The [α.sub.2]-Heremans-Schmid glycoprotein (AHSG; fetuin-A in animals) impairs insulin signaling in vitro and in rodents. Whether AHSG is associated with insulin resistance in humans is under investigation. In an animal [...]

Published
2006

231. Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

Author

Ji, Yingjie, Yiorkas, Andrianos M., Frau, Francesca, Mook-Kanamori, Dennis, Staiger, Harald, Thomas, E. Louise, Atabaki-Pasdar, Naeimeh, Campbell, Archie, Tyrrell, Jessica, Jones, Samuel E., Beaumont, Robin N., Wood, Andrew R., Tuke, Marcus A., Ruth, Katherine S., Mahajan, Anubha, Murray, Anna, Freathy, Rachel M., Weedon, Michael N., Hattersley, Andrew T., Hayward, Caroline, Machann, Juergen, Haering, Hans-Ulrich, Franks, Paul W., de Mutsert, Renee, Pearson, Ewan, Stefan, Norbert, Frayling, Timothy M., Allebrandt, Karla V., Bell, Jimmy D., Blakemore, Alexandra I., Yaghootkar, Hanieh, Ji, Yingjie, Yiorkas, Andrianos M., Frau, Francesca, Mook-Kanamori, Dennis, Staiger, Harald, Thomas, E. Louise, Atabaki-Pasdar, Naeimeh, Campbell, Archie, Tyrrell, Jessica, Jones, Samuel E., Beaumont, Robin N., Wood, Andrew R., Tuke, Marcus A., Ruth, Katherine S., Mahajan, Anubha, Murray, Anna, Freathy, Rachel M., Weedon, Michael N., Hattersley, Andrew T., Hayward, Caroline, Machann, Juergen, Haering, Hans-Ulrich, Franks, Paul W., de Mutsert, Renee, Pearson, Ewan, Stefan, Norbert, Frayling, Timothy M., Allebrandt, Karla V., Bell, Jimmy D., Blakemore, Alexandra I., and Yaghootkar, Hanieh

Abstract

Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined MRI data with genome-wide association studies of body fat percentage (%) and metabolic traits. We report 14 alleles, including 7 newly characterized alleles, associated with higher adiposity but a favorable metabolic profile. Consistent with previous studies, individuals carrying more favorable adiposity alleles had higher body fat % and higher BMI but lower risk of type 2 diabetes, heart disease, and hypertension. These individuals also had higher subcutaneous fat but lower liver fat and a lower visceral-to-subcutaneous adipose tissue ratio. Individual alleles associated with higher body fat % but lower liver fat and lower risk of type 2 diabetes included those in PPARG, GRB14, and IRS1, whereas the allele in ANKRD55 was paradoxically associated with higher visceral fat but lower risk of type 2 diabetes. Most identified favorable adiposity alleles are associated with higher subcutaneous and lower liver fat, a mechanism consistent with the beneficial effects of storing excess triglycerides in metabolically low-risk depots.

Published
2019
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236. Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion.

Author

Hudak, Sarah, Huber, Philipp, Lamprinou, Apostolia, Fritsche, Louise, Stefan, Norbert, Peter, Andreas, Birkenfeld, Andreas L., Fritsche, Andreas, Heni, Martin, and Wagner, Robert

Subjects
INSULIN sensitivity, INTERSTIMULUS interval, SECRETION, GLUCOSE tolerance tests, STATISTICAL reliability
Abstract

Aims: Insulin sensitivity and insulin secretion can be estimated by multiple indices from fasting blood samples or blood samples obtained during oral glucose tolerance tests. The test-retest reliability of these indices in repeated measurements within the same individuals can strongly vary. Methods: We analyzed data of persons without diabetes who underwent two repeated OGTTs. For each measurement pair, we calculated multiple commonly used indices for the assessment of insulin secretion and insulin sensitivity. We then evaluated the coefficient of variation (standard deviation/mean) and discriminant ratio for each index. Results: 89 persons underwent two OGTTs with a median interval of 86 days (IQR 64–249). Among indices of insulin sensitivity derived from fasting blood samples, the revised quantitative insulin sensitivity check index had the smallest coefficient of variation (2.8 ± 2.1%) whereas the C-peptide based homeostasis model assessment 2 had the highest discriminant ratio (1.97 (1.65–2.39)). As for insulin sensitivity indices that are based on OGTT, the oral glucose insulin sensitivity index had the smallest coefficient of variation (6.5 ± 5.1%). The highest discriminant ratio was found for the non-esterified fatty acids-based insulin sensitivity index (NEFA-ISI, 2.70 (2.30–3.22)). For the assessment of insulin secretion from fasting variables, the lowest mean coefficient of variation was found for C-peptide based homeostasis model assessment 2 beta with 10.8 ± 8% and the highest discriminant ratio for the C-peptide / Glucose-Ratio (2.18 (1.84–2.63)). Among indices assessing insulin secretion from an OGTT, the lowest coefficient of variation was found for the ratio of the areas under the C-peptide and glucose curves from 0 to 120 minutes with 11.3 ± 9.7%. Conclusion: The data reveal large differences in the reproducibility and the discrimination capability of different indices that assess insulin sensitivity or insulin secretion. Our findings can aid the selection of an appropriate index in clinical studies. [ABSTRACT FROM AUTHOR]

Published
2021
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238. Adiponectin in Youth

Author

Stefan, Norbert, Stumvoll, Michael, Häring, Hans-Ulrich, and Fritsche, Andreas

Published
2004

243. Glucose Allostasis

Author

Stumvoll, Michael, Tataranni, P. Antonio, Stefan, Norbert, Vozarova, Barbora, and Bogardus, Clifton

Published
2003

249. Glucose allostasis. (Perspectives in Diabetes)

Author

Stumvoll, Michael, Tataranni, P. Antonio, Stefan, Norbert, Vozarova, Barbora, and Bogardus, Clifton

Subjects
Insulin resistance -- Physiological aspects -- Risk factors, Glucose metabolism -- Physiological aspects, Type 2 diabetes -- Risk factors, Health, Physiological aspects, Risk factors
Abstract

In many organisms, normoglycemia is achieved by a tight coupling of nutrient-stimulated insulin secretion in the pancreatic β-cell (acute insulin response [AIR]) and the metabolic action of insulin to stimulate glucose disposal (insulin action [M]). It is widely accepted that in healthy individuals with normal glucose tolerance, normoglycemia can always be maintained by compensatorily increasing AIR in response to decreasing M (and vice versa). This has been mathematically described by the hyperbolic relationship between AIR and M and referred to as glucose homeostasis, with glucose concentration assumed to remain constant along the hyperbola. Conceivably, glucose is one of the signals stimulating AIR in response to decreasing M. Hypothetically, as with any normally functioning feed-forward system, AIR should not fully compensate for worsening M, since this would remove the stimulus for the compensation. We provide evidence from cross-sectional, longitudinal, and prospective data from Pima Indians (n = 413) and Caucasians (n = 60) that fasting and postprandial glucose concentrations increase with decreasing M despite normal compensation of AIR. For this physiologic adaptation to chronic stress (insulin resistance), we propose to use the term 'glucose allostasis.' Allostasis (stability through change) ensures the continued homeostatic response (stability through staying the same) to acute stress at some cumulative costs to the system. With increasing severity and over time, the allostatic load (increase in glycemia) may have pathological consequences, such as the development of type 2 diabetes. Diabetes 52:903-909, 2003, Insulin action and secretion are the principal determinants of glycemia. In people with normal glucose tolerance (NGT), a decrease in insulin action (M) is accompanied by upregulation of insulin secretion [...]

Published
2003

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