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1,341 results on '"Song, Hongjun"'

202. Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

Author

Jacob, Fadi, primary, Pather, Sarshan R., additional, Huang, Wei-Kai, additional, Zhang, Feng, additional, Wong, Samuel Zheng Hao, additional, Zhou, Haowen, additional, Cubitt, Beatrice, additional, Fan, Wenqiang, additional, Chen, Catherine Z., additional, Xu, Miao, additional, Pradhan, Manisha, additional, Zhang, Daniel Y., additional, Zheng, Wei, additional, Bang, Anne G., additional, Song, Hongjun, additional, Carlos de la Torre, Juan, additional, and Ming, Guo-li, additional

Published
2020
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204. List of Contributors

Author

Beliën, Jeroen A.M., primary, Beltramo, Riccardo, additional, Bianchini, Paulo, additional, Blau, Axel, additional, Branco, Tiago, additional, Cella Zanacchi, Francesca, additional, Cheng, Ji-Xin, additional, Dal Maschio, Marco, additional, De Stasi, Angela Michela, additional, Diaspro, Alberto, additional, Difato, Francesco, additional, Dilipkumar, Shilpa, additional, Dubois, Arnaud, additional, Ewers, Helge, additional, Fellin, Tommaso, additional, Fernández-Busnadiego, Rubén, additional, Houtsmuller, A.B., additional, Hu, Bing, additional, Hu, Chun-Rui, additional, Lucic, Vladan, additional, Ming, Guo-li, additional, Mondal, Partha P., additional, Nägerl, U.Valentin, additional, Nigg, A., additional, Ronzitti, Emiliano, additional, Sailor, Kurt A., additional, Song, Hongjun, additional, Staras, Kevin, additional, van Cappellen, W.A., additional, and Wouterlood, Floris G., additional

Published
2012
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209. Astroglia induce neurogenesis from adult neural stem cells

Author

Song, Hongjun, Stevens, Charles F., and Gage, Fred H.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Hongjun Song [1, 2]; Charles F. Stevens (corresponding author) [1]; Fred H. Gage (corresponding author) [2] New cells are generated throughout the central nervous system (CNS) well into adulthood [...]

Published
2002
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217. Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics

Author

Wang, Li, primary, Muneer, Adil, additional, Xie, Ling, additional, Zhang, Feng, additional, Wu, Bing, additional, Mei, Liu, additional, Lenarcic, Erik M, additional, Feng, Emerald Hillary, additional, Song, Juan, additional, Xiong, Yan, additional, Yu, Xufen, additional, Wang, Charles, additional, Gheorghe, Ciprian, additional, Torralba, Karina, additional, Cook, Jeanette Gowen, additional, Wan, Yisong Y., additional, Moorman, Nathaniel John, additional, Song, Hongjun, additional, Jin, Jian, additional, and Chen, Xian, additional

Published
2020
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220. Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases

Author

Lu, Leina, primary, Liu, Xiaoxiao, additional, Huang, Wei-Kai, additional, Giusti-Rodríguez, Paola, additional, Cui, Jian, additional, Zhang, Shanshan, additional, Xu, Wanying, additional, Wen, Zhexing, additional, Ma, Shufeng, additional, Rosen, Jonathan D., additional, Xu, Zheng, additional, Bartels, Cynthia F., additional, Kawaguchi, Riki, additional, Hu, Ming, additional, Scacheri, Peter C., additional, Rong, Zhili, additional, Li, Yun, additional, Sullivan, Patrick F., additional, Song, Hongjun, additional, Ming, Guo-li, additional, Li, Yan, additional, and Jin, Fulai, additional

Published
2020
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221. Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

Author

Jacob, Fadi, primary, Pather, Sarshan R., additional, Huang, Wei-Kai, additional, Wong, Samuel Zheng Hao, additional, Zhou, Haowen, additional, Zhang, Feng, additional, Cubitt, Beatrice, additional, Chen, Catherine Z., additional, Xu, Miao, additional, Pradhan, Manisha, additional, Zhang, Daniel Y., additional, Zheng, Wei, additional, Bang, Anne G., additional, Song, Hongjun, additional, de a Torre, Juan Carlos, additional, and Ming, Guo-li, additional

Published
2020
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223. Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

Author

Qian, Xuyu, primary, Su, Yijing, additional, Adam, Christopher D., additional, Deutschmann, Andre U., additional, Pather, Sarshan R., additional, Goldberg, Ethan M., additional, Su, Kenong, additional, Li, Shiying, additional, Lu, Lu, additional, Jacob, Fadi, additional, Nguyen, Phuong T.T., additional, Huh, Sooyoung, additional, Hoke, Ahmet, additional, Swinford-Jackson, Sarah E., additional, Wen, Zhexing, additional, Gu, Xiaosong, additional, Pierce, R. Christopher, additional, Wu, Hao, additional, Briand, Lisa A., additional, Chen, H. Isaac, additional, Wolf, John A., additional, Song, Hongjun, additional, and Ming, Guo-li, additional

Published
2020
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225. An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

Author

Song, Guang, primary, Lee, Emily M., additional, Pan, Jianbo, additional, Xu, Miao, additional, Rho, Hee-Sool, additional, Cheng, Yichen, additional, Whitt, Nadia, additional, Yang, Shu, additional, Kouznetsova, Jennifer, additional, Klumpp-Thomas, Carleen, additional, Michael, Samuel G., additional, Moore, Cedric, additional, Yoon, Ki-Jun, additional, Christian, Kimberly M., additional, Simeonov, Anton, additional, Huang, Wenwei, additional, Xia, Menghang, additional, Huang, Ruili, additional, Lal-Nag, Madhu, additional, Tang, Hengli, additional, Zheng, Wei, additional, Qian, Jiang, additional, Song, Hongjun, additional, Ming, Guo-li, additional, and Zhu, Heng, additional

Published
2020
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232. A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

Author

Jacob, Fadi, primary, Salinas, Ryan D., additional, Zhang, Daniel Y., additional, Nguyen, Phuong T.T., additional, Schnoll, Jordan G., additional, Wong, Samuel Zheng Hao, additional, Thokala, Radhika, additional, Sheikh, Saad, additional, Saxena, Deeksha, additional, Prokop, Stefan, additional, Liu, Di-ao, additional, Qian, Xuyu, additional, Petrov, Dmitriy, additional, Lucas, Timothy, additional, Chen, H. Isaac, additional, Dorsey, Jay F., additional, Christian, Kimberly M., additional, Binder, Zev A., additional, Nasrallah, MacLean, additional, Brem, Steven, additional, O’Rourke, Donald M., additional, Ming, Guo-li, additional, and Song, Hongjun, additional

Published
2020
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236. Contributors

Author

Arnsten, Amy, primary, Abosch, Aviva, additional, Asbury, Arthur A., additional, Bolay, Hayrunnisa, additional, Colamarino, Sophia A., additional, Comella, Cynthia L., additional, Cummins, Theodore R., additional, Danton, Gary H., additional, Dietrich, W. Dalton, additional, Engel, Jerome, additional, Fischbeck, Kenneth H., additional, Frackowiak, R.S.J., additional, Gage, Fred H., additional, Geschwind, Daniel H., additional, Goldman, Steve, additional, Hall, Edward D., additional, Hallett, Mark, additional, Heemskerk, Jill, additional, Heninger, George R., additional, Hsia, Amie W., additional, Isacson, Ole, additional, Jankovic, Joseph, additional, Kullman, Dmitri M., additional, Lie, D. Chichung, additional, Marek, Kenneth L., additional, Massicotte, Christiane, additional, Mazziotta, John C., additional, McMahon, Stephen B., additional, Moskowitz, Michael A., additional, Murinson, Beth, additional, Park, James H., additional, Price, Donald L., additional, Rudick, Richard A., additional, Ruff, Robert L., additional, Schellinger, Peter D., additional, Scherer, Steven, additional, Shoemaker, Lorelei D., additional, Simpson, Lance, additional, Song, Hongjun, additional, Strittmatter, Stephen, additional, Sullivan, Patrick G., additional, Tuszynski, Mark H., additional, Vitek, Jerrold L., additional, Voller, Bernhard, additional, Walter, Benjamin L., additional, Warach, Steven, additional, Waxman, Steven G., additional, and Wood, John N., additional

Published
2005
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237. The Role of Animal Models in Evaluating Reasonable Safety and Efficacy for Human Trials of Cell-Based Interventions for Neurologic Conditions

Author

Regenberg, Alan, Mathews, Debra JH, Blass, David M, Bok, Hilary, Coyle, Joseph T, Duggan, Patrick, Faden, Ruth, Finkel, Julia, Gearhart, John D, Hillis, Argye, Hoke, Ahmet, Johnson, Richard, Johnston, Michael, Kahn, Jeffrey, Kerr, Douglas, King, Patricia, Kurtzberg, Joanne, Liao, S Matthew, McDonald, John W, McKhann, Guy, Nelson, Karin B, Rao, Mahendra, Siegel, Andrew W, Smith, Kirby, Solter, Davor, Song, Hongjun, Sugarman, Jeremy, Vescovi, Angelo, Young, Wise, Greely, Henry T, and Traystman, Richard J

Published
2009
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238. A previously undetected pathology of Zika virus infection

Author

Christian, Kimberly M, Song, Hongjun, and Ming, Guo-li

Subjects
Zika virus infection -- Development and progression -- Care and treatment, Genetic disorders -- Development and progression -- Care and treatment, Biological sciences, Health
Abstract

Author(s): Kimberly M Christian [1]; Hongjun Song [1, 2, 3]; Guo-li Ming (corresponding author) [1, 2] It has been two years since the World Health Organization (WHO) declared concern over [...]

Published
2018
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242. Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state

Author

Jimenez-Cyrus, Dennisse, Adusumilli, Vijay S., Stempel, Max H., Maday, Sandra, Ming, Guo-li, Song, Hongjun, and Bond, Allison M.

Abstract

Quiescent adult neural stem cells (NSCs) in the mammalian brain arise from proliferating NSCs during development. Beyond acquisition of quiescence, an adult NSC hallmark, little is known about the process, milestones, and mechanisms underlying the transition of developmental NSCs to an adult NSC state. Here, we performed targeted single-cell RNA-seq analysis to reveal the molecular cascade underlying NSC development in the early postnatal mouse dentate gyrus. We identified two sequential steps, first a transition to quiescence followed by further maturation, each of which involved distinct changes in metabolic gene expression. Direct metabolic analysis uncovered distinct milestones, including an autophagy burst before NSC quiescence acquisition and cellular reactive oxygen species level elevation along NSC maturation. Functionally, autophagy is important for the NSC transition to quiescence during early postnatal development. Together, our study reveals a multi-step process with defined milestones underlying establishment of the adult NSC pool in the mammalian brain.

Published
2024
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243. Imaging Algorithm for Arc Synthetic Aperture Radar Using Frequency Modulated Continuous Wave

Author

Lu Matt, Song Hongjun, and Luo Yunhua

Subjects
Frequency-Modulated Continuous Wave (FMCW), Computer Science::Graphics, lcsh:Technology (General), Arc Synthetic Aperture Radar (Arc-SAR), lcsh:T1-995, Physics::Atmospheric and Oceanic Physics, Two dimensional frequency domain algorithms
Abstract

Arc Synthetic Aperture Radar (Arc-SAR) is a new operation-mode radar that is suitable for wide observation in certain areas. With its high resolution, wide observation area, and short repetition visit period, Arc-SAR is widely used in monitoring deformation measurements, landslides, and natural hazards. Because of the special movement of Arc-SAR, the BackproPagation Algorithm (BPA) is widely used in its image processing. Here, we propose a novel two-dimensional frequency domain algorithm to process an Arc-SAR signal. First, we derive a signal model of Arc-SAR based on that of frequency-modulated continuous-wave radar. Next, because the length of the arm is far shorter than the distance of the antenna to the target, the signal can be processed in a 2D frequency domain. Finally, we analyze the error of the frequency method used. This algorithm has the advantages of high computation speed and accuracy. The simulation and experimental data results confirm the effectiveness and validity of the proposed method.

Published
2016

244. DISC1 Partners with GSK3[beta] in Neurogenesis

Author

Ming, Guo-Li and Song, Hongjun

Subjects
Mental illness -- Development and progression, Neurosciences, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2009.03.005 Byline: Guo-li Ming (1)(2)(3), Hongjun Song (1)(2)(3) Abstract: The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3[beta]/[beta]-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders. Author Affiliation: (1) Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (2) Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (3) The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Published
2009

245. Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

Author

Juopperi Tarja A, Kim Woon, Chiang Cheng-Hsuan, Yu Huimei, Margolis Russell L, Ross Christopher A, Ming Guo-li, and Song Hongjun

Subjects
Huntington’s disease, Induced pluripotent stem cells, Neural differentiation, Astrocytes, Disease modeling, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Huntington’s Disease (HD) is a devastating neurodegenerative disorder that clinically manifests as motor dysfunction, cognitive impairment and psychiatric symptoms. There is currently no cure for this progressive and fatal disorder. The causative mutation of this hereditary disease is a trinucleotide repeat expansion (CAG) in the Huntingtin gene that results in an expanded polyglutamine tract. Multiple mechanisms have been proposed to explain the preferential striatal and cortical degeneration that occurs with HD, including non-cell-autonomous contribution from astrocytes. Although numerous cell culture and animal models exist, there is a great need for experimental systems that can more accurately replicate the human disease. Human induced pluripotent stem cells (iPSCs) are a remarkable new tool to study neurological disorders because this cell type can be derived from patients as a renewable, genetically tractable source for unlimited cells that are difficult to acquire, such as neurons and astrocytes. The development of experimental systems based on iPSC technology could aid in the identification of molecular lesions and therapeutic treatments. Results We derived iPSCs from a father with adult onset HD and 50 CAG repeats (F-HD-iPSC) and his daughter with juvenile HD and 109 CAG repeats (D-HD-iPSC). These disease-specific iPSC lines were characterized by standard assays to assess the quality of iPSC lines and to demonstrate their pluripotency. HD-iPSCs were capable of producing phenotypically normal, functional neurons in vitro and were able to survive and differentiate into neurons in the adult mouse brain in vivo after transplantation. Surprisingly, when HD-iPSCs were directed to differentiate into an astrocytic lineage, we observed the presence of cytoplasmic, electron clear vacuoles in astrocytes from both F-HD-iPSCs and D-HD-iPSCs, which were significantly more pronounced in D-HD-astrocytes. Remarkably, the vacuolation in diseased astrocytes was observed under basal culture conditions without additional stressors and increased over time. Importantly, similar vacuolation phenotype has also been observed in peripheral blood lymphocytes from individuals with HD. Together, these data suggest that vacuolation may be a phenotype associated with HD. Conclusions We have generated a unique in vitro system to study HD pathogenesis using patient-specific iPSCs. The astrocytes derived from patient-specific iPSCs exhibit a vacuolation phenotype, a phenomenon previously documented in primary lymphocytes from HD patients. Our studies pave the way for future mechanistic investigations using human iPSCs to model HD and for high-throughput therapeutic screens.

Published
2012
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246. Human Adult Neurogenesis: Evidence and Remaining Question

Author

Kempermann, Gerd, Gage, Fred H, Aigner, Ludwig, Song, Hongjun, Curtis, Maurice A, Thuret, Sandrine, Kuhn, H Georg, Jessberger, Sebastian, Frankland, Paul W, Cameron, Heather A, Gould, Elizabeth, Hen, Rene, Abrous, D Nora, Toni, Nicolas, Schinder, Alejandro F, Zhao, Xinyu, Lucassen, Paul J, Frisén, Jonas, University of Zurich, and Kempermann, Gerd

Subjects
1307 Cell Biology, 10242 Brain Research Institute, 1311 Genetics, 1313 Molecular Medicine, 570 Life sciences, biology, 610 Medicine & health
Published
2018

247. Tet2negatively regulates memory fidelity

Author

Zengeler, Kristine E., primary, Gettens, Caroline P., additional, Smith, Hannah C., additional, Caron, Mallory M., additional, Zhang, Xinyuan, additional, Howard, Alexandra H., additional, Boitnott, Andrea R., additional, Gogliettino, Alex R., additional, Reda, Anas, additional, Malachowsky, Beth G., additional, Zhong, Chun, additional, Song, Hongjun, additional, Kaas, Garrett A., additional, and Kennedy, Andrew J., additional

Published
2019
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249. Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR-mutant glioblastoma

Author

Makhlin, Igor, primary, Salinas, Ryan D, additional, Zhang, Daniel, additional, Jacob, Fadi, additional, Ming, Gou-li, additional, Song, Hongjun, additional, Saxena, Deeksha, additional, Dorsey, Jay F, additional, Nasrallah, MacLean P, additional, Morrissette, Jennifer JD, additional, Binder, Zev A, additional, O'Rourke, Donald M, additional, Desai, Arati S, additional, Brem, Steven, additional, and Bagley, Stephen J, additional

Published
2019
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