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895 results on '"Smyth, Susan"'

208. Mice With Targeted Inactivation of Ppap2b in Endothelial and Hematopoietic Cells Display Enhanced Vascular Inflammation and Permeability

Author

Panchatcharam, Manikandan, primary, Salous, Abdel K., additional, Brandon, Jason, additional, Miriyala, Sumitra, additional, Wheeler, Jessica, additional, Patil, Pooja, additional, Sunkara, Manjula, additional, Morris, Andrew J., additional, Escalante-Alcalde, Diana, additional, and Smyth, Susan S., additional

Published
2014
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211. Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes

Author

Smyth, Susan S., primary, Moliterno, David J., primary, Rorick, Tyrus L., primary, Moccetti, Tiziano, primary, Valgimigli, Marco, primary, Dery, Jean Pierre, primary, Cornel, Jan H., primary, Thomas, Gregory S., primary, Huber, Kurt, primary, Harrington, Robert A., primary, Hord, Edward, primary, Judge, Heather M., primary, Chen, Edmond, primary, Strony, John, primary, Mahaffey, Kenneth W., primary, Tricoci, Pierluigi, primary, Becker, Richard C., primary, Storey, Robert F., additional, Kotha, Jayaprakash, additional, and Jennings, Lisa K., additional

Published
2014
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212. Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets: STUDIES USING CHEMICAL INHIBITORS OF LIPID PHOSPHATE PHOSPHATASE ACTIVITY

Author

Wang, Zuncai, Morris, Andrew J., Smyth, Susan S., Sigal, Yury J., Prestwich, Glenn D., Sciorra, Vicki A., Pamuklar, Zehra, and Xu, Yong

Subjects
lipids (amino acids, peptides, and proteins), biological phenomena, cell phenomena, and immunity
Abstract

Blood platelets play an essential role in ischemic heart disease and stroke contributing to acute thrombotic events by release of potent inflammatory agents within the vasculature. Lysophosphatidic acid (LPA) is a bioactive lipid mediator produced by platelets and found in the blood and atherosclerotic plaques. LPA receptors on platelets, leukocytes, endothelial cells, and smooth muscle cells regulate growth, differentiation, survival, motility, and contractile activity. Definition of the opposing pathways of synthesis and degradation that control extracellular LPA levels is critical to understanding how LPA bioactivity is regulated. We show that intact platelets and platelet membranes actively dephosphorylate LPA and identify the major enzyme responsible as lipid phosphate phosphatase 1 (LPP1). Localization of LPP1 to the platelet surface is increased by exposure to LPA. A novel receptor-inactive sn-3-substituted difluoromethylenephosphonate analog of phosphatidic acid that is a potent competitive inhibitor of LPP1 activity potentiates platelet aggregation and shape change responses to LPA and amplifies LPA production by agonist-stimulated platelets. Our results identify LPP1 as a pivotal regulator of LPA signaling in the cardiovascular system. These findings are consistent with genetic and cell biological evidence implicating LPPs as negative regulators of lysophospholipid signaling and suggest that the mechanisms involve both attenuation of lysophospholipid actions at cell surface receptors and opposition of lysophospholipid production.

Published
2003
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213. Invasive Coronary Vasoreactivity Testing to Diagnose Microvascular Dysfunction in Women⁎⁎Editorials published in JACC: Cardiovascular Interventions reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Interventions or the American College of Cardiology

Author

Bailey, Alison L. and Smyth, Susan S.

Subjects
microvascular dysfunction, vasoreactivity, WISE study, Cardiology and Cardiovascular Medicine, coronary flow velocity reserve (CFR)
Published
2012
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215. Tiny dancers: the integrin–growth factor nexus in angiogenic signaling

Author

Patterson, Cam and Smyth, Susan S.

Abstract

A vital step in growth factor-driven angiogenesis is the coordinated engagement of endothelial integrins with the extracellular matrix. The molecular mechanisms that partner growth factors and integrins are being elucidated, revealing an intricate interaction of surface receptors and their signaling pathways.

Published
2002
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220. Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation

Author

Park, Gye Young, primary, Lee, Yong Gyu, additional, Berdyshev, Evgeny, additional, Nyenhuis, Sharmilee, additional, Du, Jian, additional, Fu, Panfeng, additional, Gorshkova, Irina A., additional, Li, Yongchao, additional, Chung, Sangwoon, additional, Karpurapu, Manjula, additional, Deng, Jing, additional, Ranjan, Ravi, additional, Xiao, Lei, additional, Jaffe, H. Ari, additional, Corbridge, Susan J., additional, Kelly, Elizabeth A. B., additional, Jarjour, Nizar N., additional, Chun, Jerold, additional, Prestwich, Glenn D., additional, Kaffe, Eleanna, additional, Ninou, Ioanna, additional, Aidinis, Vassilis, additional, Morris, Andrew J., additional, Smyth, Susan S., additional, Ackerman, Steven J., additional, Natarajan, Viswanathan, additional, and Christman, John W., additional

Published
2013
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225. Bioactive Lipids and Cationic Antimicrobial Peptides as New Potential Regulators for Trafficking of Bone Marrow-Derived Stem Cells in Patients with Acute Myocardial Infarction

Author

Karapetyan, Anush V., primary, Klyachkin, Yuri M., additional, Selim, Samy, additional, Sunkara, Manjula, additional, Ziada, Khaled M., additional, Cohen, Donald A., additional, Zuba-Surma, Ewa K., additional, Ratajczak, Janina, additional, Smyth, Susan S., additional, Ratajczak, Mariusz Z., additional, Morris, Andrew J., additional, and Abdel-Latif, Ahmed, additional

Published
2013
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231. Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement.

Author

Sexton, Travis, Wallace, Eric, Chen, Amy, Charnigo, Richard, Reda, Hassan, Ziada, Khaled, Gurley, John, and Smyth, Susan

Abstract

Transcatheter aortic valve replacement (TAVR) has been increasingly used to treat patients with symptomatic aortic stenosis. Despite improvements in valve deployment, patients that have undergone TAVR are at high risk for major adverse events following the procedure. Blood cell numbers, platelet function, and biomarkers of systemic inflammation were analyzed in 58 patients undergoing TAVR with the Edward's SAPIEN valve. Following valve deployment, platelet count and agonist-induced platelet activity declined and plasma markers of systemic inflammation (interleukin-6 and S100A8/A9) increased. Baseline platelet activity prior to TAVR correlated with perioperative changes plasma interleukin-6 levels. Moreover, perioperative changes in plasma inflammatory markers predicted the decline in platelet count in the days following the TAVR procedure. Additionally, a significant effect of gender on platelet count following TAVR and was observed. Finally, post-procedural mortality was associated with sustained thrombocytopenia after TAVR. Our findings suggest that TAVR elicits a thromboinflammatory state that may contribute to post-procedural thrombocytopenia. Importantly, our results add to the growing body of literature that suggests the thromboinflammatory changes that occur early after TAVR may predict long-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2016
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244. Autotaxin and Its Product Lysophosphatidic Acid Suppress Brown Adipose Differentiation and Promote Diet-Induced Obesity in Mice

Author

Federico, Lorenzo, primary, Ren, Hongmei, additional, Mueller, Paul A., additional, Wu, Tao, additional, Liu, Shuying, additional, Popovic, Jelena, additional, Blalock, Eric M., additional, Sunkara, Manjula, additional, Ovaa, Huib, additional, Albers, Harald M., additional, Mills, Gordon B., additional, Morris, Andrew J., additional, and Smyth, Susan S., additional

Published
2012
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246. Platelet Biology and Response to Antiplatelet Therapy in Women

Author

Wang, Tracy Y., primary, Angiolillo, Dominick J., additional, Cushman, Mary, additional, Sabatine, Marc S., additional, Bray, Paul F., additional, Smyth, Susan S., additional, Dauerman, Harold L., additional, French, Patricia A., additional, and Becker, Richard C., additional

Published
2012
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248. PHARMACODYNAMICS OF VORAPAXAR, A PLATELET PAR-1 ANTAGONIST, AND ITS INTERACTION WITH P2Y12 RECEPTOR PATHWAY IN THE TRACER TRIAL

Author

Jennings, Lisa K., primary, Moliterno, David, additional, Storey, Robert, additional, Hord, Edward, additional, Kotha, Jayaprakash, additional, Becker, Richard, additional, Smyth, Susan, additional, Providencia, Luis, additional, Moccetti, Tiziano, additional, Valgimigli, Marco, additional, Dery, Jean-Pierre, additional, Cornel, J.H., additional, Thomas, Gregory, additional, Huber, Kurt, additional, Chen, Edmond, additional, Strony, John, additional, Rorick, Tyrus, additional, Tricoci, Pierluigi, additional, and Mahaffey, Kenneth, additional

Published
2012
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249. INCREASED MORBIDITY AND MORTALITY AMONG ATRIAL FIBRILLATION PATIENTS WITH PROLONGED QRS: RESULTS FROM THE AFFIRM STUDY

Author

Whitbeck, Matthew, primary, Charnigo, Richard, additional, Fornwalt, Brandon, additional, Morales, Gustavo, additional, Shah, Jignesh, additional, Zegarra, Milagros M., additional, Bailey, Alison, additional, Anaya, Paul, additional, Macaulay, Tracy, additional, Campbell, Charles, additional, Gurley, John, additional, Ziada, Khaled, additional, Rong, Bai, additional, Biase, Luigi Di, additional, Natale, Andrea, additional, Smyth, Susan, additional, Moliterno, David, additional, and Elayi, Claude S., additional

Published
2012
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