Search

Your search keyword '"Smith, Erin"' showing total 2,951 results
Start Over Author "Smith, Erin"
2,951 results on '"Smith, Erin"'

205. Daily Session Schedule

Author

Rauch, Sheila A. M., primary, Rothbaum, Barbara O., additional, Smith, Erin R., additional, and Foa, Edna B., additional

Published
2020
Full Text
View/download PDF

208. Exposure in PE-IOP

Author

Rauch, Sheila A. M., primary, Rothbaum, Barbara O., additional, Smith, Erin R., additional, and Foa, Edna B., additional

Published
2020
Full Text
View/download PDF

212. Case Management

Author

Rauch, Sheila A. M., primary, Rothbaum, Barbara O., additional, Smith, Erin R., additional, and Foa, Edna B., additional

Published
2020
Full Text
View/download PDF

214. A Survey of 3.3 Micron PAH Emission in Planetary Nebulae

Author

Smith, Erin C. D. and McLean, Ian S.

Subjects
Astrophysics
Abstract

Results are presented from a pilot survey of 3.3 micron PAH emission from planetary nebulae using FLITECAM, an instrument intended for airborne astronomy with SOFIA. The observations were made during ground-based commissioning of FLITECAM's spectroscopic mode at the 3-m Shane telescope at Lick Observatory. Direct-ruled KRS-5 grisms were used to give a resolving power (R)~1,700. Targets were selected from IRAS, KAO and ISO sources with previously observed PAH emission at longer wavelengths. AGB stars and PN with C/O ratios < 1 were also added to the target list in order to test PAH detection thresholds. In all, 20 objects were observed. PAH emission was detected in 11 out of 20 observed targets., Comment: 8 pages, 2 tables, 4 figures, accepted to ApJ

Published
2007
Full Text
View/download PDF

216. Ongoing war between Israel and Hamas reaches new tensions - The Charger Bulletin

Author

Smith, Erin

Subjects
Israel-Arab conflicts -- Military aspects, Terrorist organizations -- Military aspects, News, opinion and commentary, Sports and fitness
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> On Oct. 7, Hamas, a Palestinian terrorist organization, launched an unprecedented attack by sea, air and ground on Israel. Rockets hit Israeli cities and thousands [...]

Published
2023

217. House of Representatives lacking leadership - The Charger Bulletin

Author

Smith, Erin

Subjects
United States. House of Representatives -- Political activity, Political parties, Legislators -- Political aspects -- Political activity, News, opinion and commentary, Sports and fitness, Republican Party (United States) -- Political activity -- Political aspects
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> One week after Kevin McCarthy (R-Cal.) was ousted as the Speaker of the House of Representatives, the House Republicans have still not found a replacement. [...]

Published
2023

218. Kevin McCarthy ousted as House Speaker - The Charger Bulletin

Author

Smith, Erin

Subjects
United States. House of Representatives -- Political activity, Political parties, News, opinion and commentary, Sports and fitness
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> Kevin McCarthy (R-Cal.) was voted out of his United States House of Representatives speakership on Oct. 3 by a 216-210 vote. 208 House Democrats voted [...]

Published
2023

219. Firearm open carry criminalized in CT - The Charger Bulletin

Author

Smith, Erin

Subjects
Government regulation, News, opinion and commentary, Sports and fitness
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> As of Oct. 1, 2023, the open carrying of a firearm is now illegal in Connecticut. The new law came into effect due to complaints [...]

Published
2023

220. CT minimum wage increases by 69 cents - The Charger Bulletin

Author

Smith, Erin

Subjects
Wages -- Minimum wage, News, opinion and commentary, Sports and fitness
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> On Sept. 18, Governor Ned Lamont announced at a press conference that effective Jan. 1, 2024, the Connecticut minimum wage will be increased from $15.00 [...]

Published
2023

221. MARB implements financial management firm in West Haven

Author

Smith, Erin

Subjects
Financial management, Company business management, Company financing, News, opinion and commentary, Sports and fitness
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> The Municipal Accountability Review Board is a state board that provides oversight to financially distressed municipalities. West Haven was moved to the board's highest tier [...]

Published
2023

222. CT Senator Blumenthal announces funding for synagogues to combat antisemitism

Author

Smith, Erin

Subjects
Antisemitism, Mediation, News, opinion and commentary, Sports and fitness
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> Last fall, Kanye West flooded social media with antisemitic comments, leading to the disabling of his social media accounts. These comments on social media had [...]

Published
2023

223. West Haven's Sept. 12 Primary Election - The Charger Bulletin

Author

Smith, Erin

Subjects
Primaries, News, opinion and commentary, Sports and fitness, Republican Party (United States)
Abstract

Byline: Erin Smith content'class='sno-story-body-content sno-no-cap'> Election season is off to a start in Connecticut on Tuesday, Sept. 12. The state will hold races in 12 Democratic towns and 14 Republican [...]

Published
2023

224. Postconcussive symptoms (PCS) following combat-related traumatic brain injury (TBI) in Veterans with posttraumatic stress disorder (PTSD): Influence of TBI, PTSD, and depression on symptoms measured by the Neurobehavioral Symptom Inventory (NSI)

Author

Porter, Katherine E., Stein, Murray B., Martis, Brian, Avallone, Kimberly M., McSweeney, Lauren B., Smith, Erin R., Simon, Naomi M., Gargan, Sean, Liberzon, Israel, Hoge, Charles W., and Rauch, Sheila A.M.

Published
2018
Full Text
View/download PDF

226. Genome-wide association study of age at menarche in African-American women

Author

Demerath, Ellen W, Liu, Ching-Ti, Franceschini, Nora, Chen, Gary, Palmer, Julie R, Smith, Erin N, Chen, Christina TL, Ambrosone, Christine B, Arnold, Alice M, Bandera, Elisa V, Berenson, Gerald S, Bernstein, Leslie, Britton, Angela, Cappola, Anne R, Carlson, Christopher S, Chanock, Stephen J, Chen, Wei, Chen, Zhao, Deming, Sandra L, Elks, Cathy E, Evans, Michelle K, Gajdos, Zofia, Henderson, Brian E, Hu, Jennifer J, Ingles, Sue, John, Esther M, Kerr, Kathleen F, Kolonel, Laurence N, Le Marchand, Loic, Lu, Xiaoning, Millikan, Robert C, Musani, Solomon K, Nock, Nora L, North, Kari, Nyante, Sarah, Press, Michael F, Rodriquez-Gil, Jorge L, Ruiz-Narvaez, Edward A, Schork, Nicholas J, Srinivasan, Sathanur R, Woods, Nancy F, Zheng, Wei, Ziegler, Regina G, Zonderman, Alan, Heiss, Gerardo, Windham, B Gwen, Wellons, Melissa, Murray, Sarah S, Nalls, Michael, Pastinen, Tomi, Rajkovic, Aleksandar, Hirschhorn, Joel, Cupples, L Adrienne, Kooperberg, Charles, Murabito, Joanne M, and Haiman, Christopher A

Subjects
Genetics, Aging, Prevention, Contraception/Reproduction, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Black or African American, Case-Control Studies, Child, Diabetes Mellitus, Type 2, Female, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Humans, Linear Models, Membrane Glycoproteins, Membrane Proteins, Menarche, Nuclear Receptor Subfamily 1, Group F, Member 1, Obesity, Polymorphism, Single Nucleotide, Risk Factors, White People, Young Adult, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

African-American (AA) women have earlier menarche on average than women of European ancestry (EA), and earlier menarche is a risk factor for obesity and type 2 diabetes among other chronic diseases. Identification of common genetic variants associated with age at menarche has a potential value in pointing to the genetic pathways underlying chronic disease risk, yet comprehensive genome-wide studies of age at menarche are lacking for AA women. In this study, we tested the genome-wide association of self-reported age at menarche with common single-nucleotide polymorphisms (SNPs) in a total of 18 089 AA women in 15 studies using an additive genetic linear regression model, adjusting for year of birth and population stratification, followed by inverse-variance weighted meta-analysis (Stage 1). Top meta-analysis results were then tested in an independent sample of 2850 women (Stage 2). First, while no SNP passed the pre-specified P < 5 × 10(-8) threshold for significance in Stage 1, suggestive associations were found for variants near FLRT2 and PIK3R1, and conditional analysis identified two independent SNPs (rs339978 and rs980000) in or near RORA, strengthening the support for this suggestive locus identified in EA women. Secondly, an investigation of SNPs in 42 previously identified menarche loci in EA women demonstrated that 25 (60%) of them contained variants significantly associated with menarche in AA women. The findings provide the first evidence of cross-ethnic generalization of menarche loci identified to date, and suggest a number of novel biological links to menarche timing in AA women.

Published
2013

227. Loci influencing blood pressure identified using a cardiovascular gene-centric array

Author

Ganesh, Santhi K, Tragante, Vinicius, Guo, Wei, Guo, Yiran, Lanktree, Matthew B, Smith, Erin N, Johnson, Toby, Castillo, Berta Almoguera, Barnard, John, Baumert, Jens, Chang, Yen-Pei Christy, Elbers, Clara C, Farrall, Martin, Fischer, Mary E, Franceschini, Nora, Gaunt, Tom R, Gho, Johannes MIH, Gieger, Christian, Gong, Yan, Isaacs, Aaron, Kleber, Marcus E, Leach, Irene Mateo, McDonough, Caitrin W, Meijs, Matthijs FL, Mellander, Olle, Molony, Cliona M, Nolte, Ilja M, Padmanabhan, Sandosh, Price, Tom S, Rajagopalan, Ramakrishnan, Shaffer, Jonathan, Shah, Sonia, Shen, Haiqing, Soranzo, Nicole, van der Most, Peter J, Van Iperen, Erik PA, Van Setten, Jessic A, Vonk, Judith M, Zhang, Li, Beitelshees, Amber L, Berenson, Gerald S, Bhatt, Deepak L, Boer, Jolanda MA, Boerwinkle, Eric, Burkley, Ben, Burt, Amber, Chakravarti, Aravinda, Chen, Wei, Cooper-DeHoff, Rhonda M, Curtis, Sean P, Dreisbach, Albert, Duggan, David, Ehret, Georg B, Fabsitz, Richard R, Fornage, Myriam, Fox, Ervin, Furlong, Clement E, Gansevoort, Ron T, Hofker, Marten H, Hovingh, G Kees, Kirkland, Susan A, Kottke-Marchant, Kandice, Kutlar, Abdullah, LaCroix, Andrea Z, Langaee, Taimour Y, Li, Yun R, Lin, Honghuang, Liu, Kiang, Maiwald, Steffi, Malik, Rainer, Murugesan, Gurunathan, Newton-Cheh, Christopher, O'Connell, Jeffery R, Onland-Moret, N Charlotte, Ouwehand, Willem H, Palmas, Walter, Penninx, Brenda W, Pepine, Carl J, Pettinger, Mary, Polak, Joseph F, Ramachandran, Vasan S, Ranchalis, Jane, Redline, Susan, Ridker, Paul M, Rose, Lynda M, Scharnag, Hubert, Schork, Nicholas J, Shimbo, Daichi, Shuldiner, Alan R, Srinivasan, Sathanur R, Stolk, Ronald P, Taylor, Herman A, Thorand, Barbara, Trip, Mieke D, van Duijn, Cornelia M, Verschuren, W Monique, Wijmenga, Cisca, Winkelmann, Bernhard R, Wyatt, Sharon, and Young, J Hunter

Subjects
Hypertension, Heart Disease, Human Genome, Genetics, Clinical Research, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Adult, Aged, Blood Pressure, Cardiovascular Diseases, Chromosome Mapping, Cohort Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, White People, CARDIOGRAM, METASTROKE, LifeLines Cohort Study, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ∼50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ∼2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 × 10(-6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.

Published
2013

228. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.

Author

Mangino, Massimo, Hwang, Shih-Jen, Spector, Timothy, Hunt, Steven, Kimura, Masayuki, Fitzpatrick, Annette, Christiansen, Lene, Petersen, Inge, Elbers, Clara, Harris, Tamara, Chen, Wei, Srinivasan, Sathanur, Kark, Jeremy, Benetos, Athanase, El Shamieh, Said, Visvikis-Siest, Sophie, Christensen, Kaare, Berenson, Gerald, Valdes, Ana, Viñuela, Ana, Garcia, Melissa, Arnett, Donna, Broeckel, Ulrich, Province, Michael, Pankow, James, Kammerer, Candace, Liu, Yongmei, Nalls, Michael, Tishkoff, Sarah, Thomas, Fridtjof, Psaty, Bruce, Bis, Joshua, Taylor, Kent, Smith, Erin, Schork, Nicholas, Levy, Daniel, Aviv, Abraham, Ziv, Elad, and Rotter, Jerome

Subjects
Genome-Wide Association Study, Humans, Kruppel-Like Transcription Factors, Telomere, Telomere Homeostasis, Telomere-Binding Proteins
Abstract

Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. We performed a meta-analysis of 9190 individuals from six independent GWAS and validated our findings in 2226 individuals from four additional studies. We confirmed previously reported associations with OBFC1 (rs9419958 P = 9.1 × 10(-11)) and with the telomerase RNA component TERC (rs1317082, P = 1.1 × 10(-8)). We also identified two novel genomic regions associated with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs3027234, P = 3.6 × 10(-8)) on chromosome17p13.1 and zinc finger protein 676 (ZNF676; rs412658, P = 3.3 × 10(-8)) on 19p12. The minor allele of rs3027234 was associated with both shorter LTL and lower expression of CTC1. Our findings are consistent with the recent observations that point mutations in CTC1 cause short telomeres in both Arabidopsis and humans affected by a rare Mendelian syndrome. Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population.

Published
2012

229. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

Author

Asselbergs, Folkert W, Guo, Yiran, van Iperen, Erik PA, Sivapalaratnam, Suthesh, Tragante, Vinicius, Lanktree, Matthew B, Lange, Leslie A, Almoguera, Berta, Appelman, Yolande E, Barnard, John, Baumert, Jens, Beitelshees, Amber L, Bhangale, Tushar R, Chen, Yii-Der Ida, Gaunt, Tom R, Gong, Yan, Hopewell, Jemma C, Johnson, Toby, Kleber, Marcus E, Langaee, Taimour Y, Li, Mingyao, Li, Yun R, Liu, Kiang, McDonough, Caitrin W, Meijs, Matthijs FL, Middelberg, Rita PS, Musunuru, Kiran, Nelson, Christopher P, O’Connell, Jeffery R, Padmanabhan, Sandosh, Pankow, James S, Pankratz, Nathan, Rafelt, Suzanne, Rajagopalan, Ramakrishnan, Romaine, Simon PR, Schork, Nicholas J, Shaffer, Jonathan, Shen, Haiqing, Smith, Erin N, Tischfield, Sam E, van der Most, Peter J, van Vliet-Ostaptchouk, Jana V, Verweij, Niek, Volcik, Kelly A, Zhang, Li, Bailey, Kent R, Bailey, Kristian M, Bauer, Florianne, Boer, Jolanda MA, Braund, Peter S, Burt, Amber, Burton, Paul R, Buxbaum, Sarah G, Chen, Wei, Cooper-DeHoff, Rhonda M, Cupples, L Adrienne, deJong, Jonas S, Delles, Christian, Duggan, David, Fornage, Myriam, Furlong, Clement E, Glazer, Nicole, Gums, John G, Hastie, Claire, Holmes, Michael V, Illig, Thomas, Kirkland, Susan A, Kivimaki, Mika, Klein, Ronald, Klein, Barbara E, Kooperberg, Charles, Kottke-Marchant, Kandice, Kumari, Meena, LaCroix, Andrea Z, Mallela, Laya, Murugesan, Gurunathan, Ordovas, Jose, Ouwehand, Willem H, Post, Wendy S, Saxena, Richa, Scharnagl, Hubert, Schreiner, Pamela J, Shah, Tina, Shields, Denis C, Shimbo, Daichi, Srinivasan, Sathanur R, Stolk, Ronald P, Swerdlow, Daniel I, Taylor, Herman A, Topol, Eric J, Toskala, Elina, van Pelt, Joost L, van Setten, Jessica, Yusuf, Salim, Whittaker, John C, Zwinderman, AH, Study, LifeLines Cohort, Anand, Sonia S, Balmforth, Anthony J, and Berenson, Gerald S

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Epidemiology, Health Sciences, Human Genome, Cardiovascular, Atherosclerosis, Aetiology, 2.1 Biological and endogenous factors, Cholesterol, HDL, Cholesterol, LDL, Female, Genome-Wide Association Study, Genotype, Humans, Lipids, Male, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Sex Factors, Triglycerides, White People, LifeLines Cohort Study, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering ∼2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.

Published
2012

230. Mind-Body Resilience for Women: A Focus on Depression: Developing innovative solutions for women with depression, accounting for differences in gender and sex, are critically important

Author

Smith, Erin, Heinemeyer, Mark, Chapman, Sandra Bond, Zarutskie, Paul, Wainer, Zoe, Berk, Michael, Chadha, Antonella Santuccione, and Eyre, Harris

Subjects
Women -- Health aspects, Depression, Mental -- Demographic aspects -- Diagnosis -- Development and progression, Business, Pharmaceuticals and cosmetics industries
Abstract

This article originally appeared in Psychiatric Times[TM] Depression is the leading cause of disability and a major contributor to the overall global burden of disease. (1) But as the Lancet [...]

Published
2023

231. Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens

Author

Yost, Shawn E, Smith, Erin N, Schwab, Richard B, Bao, Lei, Jung, HyunChul, Wang, Xiaoyun, Voest, Emile, Pierce, John P, Messer, Karen, Parker, Barbara A, Harismendy, Olivier, and Frazer, Kelly A

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Human Genome, Cancer, Biotechnology, Breast Cancer, Aetiology, 2.1 Biological and endogenous factors, Adult, Artifacts, Breast Neoplasms, DNA Damage, DNA Mutational Analysis, Female, Fixatives, Formaldehyde, Genome, Human, High-Throughput Nucleotide Sequencing, Humans, Mutation, Paraffin Embedding, Environmental Sciences, Information and Computing Sciences, Developmental Biology, Biological sciences, Chemical sciences, Environmental sciences
Abstract

The utilization of archived, formalin-fixed paraffin-embedded (FFPE) tumor samples for massive parallel sequencing has been challenging due to DNA damage and contamination with normal stroma. Here, we perform whole genome sequencing of DNA isolated from two triple-negative breast cancer tumors archived for >11 years as 5 µm FFPE sections and matched germline DNA. The tumor samples show differing amounts of FFPE damaged DNA sequencing reads revealed as relatively high alignment mismatch rates enriched for C · G > T · A substitutions compared to germline samples. This increase in mismatch rate is observable with as few as one million reads, allowing for an upfront evaluation of the sample integrity before whole genome sequencing. By applying innovative quality filters incorporating global nucleotide mismatch rates and local mismatch rates, we present a method to identify high-confidence somatic mutations even in the presence of FFPE induced DNA damage. This results in a breast cancer mutational profile consistent with previous studies and revealing potentially important functional mutations. Our study demonstrates the feasibility of performing genome-wide deep sequencing analysis of FFPE archived tumors of limited sample size such as residual cancer after treatment or metastatic biopsies.

Published
2012

232. Mitochondrial mutations and polymorphisms in psychiatric disorders.

Author

Sequeira, Adolfo, Martin, Maureen V, Rollins, Brandi, Moon, Emily A, Bunney, William E, Macciardi, Fabio, Lupoli, Sara, Smith, Erin N, Kelsoe, John, Magnan, Christophe N, van Oven, Mannis, Baldi, Pierre, Wallace, Douglas C, and Vawter, Marquis P

Subjects
bipolar disorder, common deletion, homoplasmy, mitochondria, novel mutations, schizophrenia, Brain Disorders, Neurosciences, Depression, Serious Mental Illness, Schizophrenia, Genetics, Mental Health, Clinical Research, Human Genome, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Underpinning research, Mental health, Clinical Sciences, Law
Abstract

Mitochondrial deficiencies with unknown causes have been observed in schizophrenia (SZ) and bipolar disorder (BD) in imaging and postmortem studies. Polymorphisms and somatic mutations in mitochondrial DNA (mtDNA) were investigated as potential causes with next generation sequencing of mtDNA (mtDNA-Seq) and genotyping arrays in subjects with SZ, BD, major depressive disorder (MDD), and controls. The common deletion of 4,977 bp in mtDNA was compared between SZ and controls in 11 different vulnerable brain regions and in blood samples, and in dorsolateral prefrontal cortex (DLPFC) of BD, SZ, and controls. In a separate analysis, association of mitochondria SNPs (mtSNPs) with SZ and BD in European ancestry individuals (n = 6,040) was tested using Genetic Association Information Network (GAIN) and Wellcome Trust Case Control Consortium 2 (WTCCC2) datasets. The common deletion levels were highly variable across brain regions, with a 40-fold increase in some regions (nucleus accumbens, caudate nucleus and amygdala), increased with age, and showed little change in blood samples from the same subjects. The common deletion levels were increased in the DLPFC for BD compared to controls, but not in SZ. Full mtDNA genome resequencing of 23 subjects, showed seven novel homoplasmic mutations, five were novel synonymous coding mutations. By logistic regression analysis there were no significant mtSNPs associated with BD or SZ after genome wide correction. However, nominal association of mtSNPs (p

Published
2012

233. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.

Author

Smith, Erin N, Koller, Daniel L, Panganiban, Corrie, Szelinger, Szabolcs, Zhang, Peng, Badner, Judith A, Barrett, Thomas B, Berrettini, Wade H, Bloss, Cinnamon S, Byerley, William, Coryell, William, Edenberg, Howard J, Foroud, Tatiana, Gershon, Elliot S, Greenwood, Tiffany A, Guo, Yiran, Hipolito, Maria, Keating, Brendan J, Lawson, William B, Liu, Chunyu, Mahon, Pamela B, McInnis, Melvin G, McMahon, Francis J, McKinney, Rebecca, Murray, Sarah S, Nievergelt, Caroline M, Nurnberger, John I, Nwulia, Evaristus A, Potash, James B, Rice, John, Schulze, Thomas G, Scheftner, William A, Shilling, Paul D, Zandi, Peter P, Zöllner, Sebastian, Craig, David W, Schork, Nicholas J, and Kelsoe, John R

Subjects
Humans, Bipolar Disorder, Computational Biology, Genotype, Polymorphism, Single Nucleotide, Exons, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Genetics, Developmental Biology
Abstract

Although a highly heritable and disabling disease, bipolar disorder's (BD) genetic variants have been challenging to identify. We present new genotype data for 1,190 cases and 401 controls and perform a genome-wide association study including additional samples for a total of 2,191 cases and 1,434 controls. We do not detect genome-wide significant associations for individual loci; however, across all SNPs, we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (P = 1.5×10(-7)). To demonstrate that this result is not likely to be a false positive, we analyze replication rates in a large meta-analysis of height and show that, in a large enough study, associations replicate as a function of power, approaching a linear relationship. Within BD, SNPs near exons exhibit a greater probability of replication, supporting an enrichment of reproducible associations near functional regions of genes. These results indicate that there is likely common genetic variation associated with BD near exons (±10 kb) that could be identified in larger studies and, further, provide a framework for assessing the potential for replication when combining results from multiple studies.

Published
2011

234. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

Author

Lanktree, Matthew B, Guo, Yiran, Murtaza, Muhammed, Glessner, Joseph T, Bailey, Swneke D, Onland-Moret, N Charlotte, Lettre, Guillaume, Ongen, Halit, Rajagopalan, Ramakrishnan, Johnson, Toby, Shen, Haiqing, Nelson, Christopher P, Klopp, Norman, Baumert, Jens, Padmanabhan, Sandosh, Pankratz, Nathan, Pankow, James S, Shah, Sonia, Taylor, Kira, Barnard, John, Peters, Bas J, Maloney, Cliona M, Lobmeyer, Maximilian T, Stanton, Alice, Zafarmand, M Hadi, Romaine, Simon PR, Mehta, Amar, van Iperen, Erik PA, Gong, Yan, Price, Tom S, Smith, Erin N, Kim, Cecilia E, Li, Yun R, Asselbergs, Folkert W, Atwood, Larry D, Bailey, Kristian M, Bhatt, Deepak, Bauer, Florianne, Behr, Elijah R, Bhangale, Tushar, Boer, Jolanda MA, Boehm, Bernhard O, Bradfield, Jonathan P, Brown, Morris, Braund, Peter S, Burton, Paul R, Carty, Cara, Chandrupatla, Hareesh R, Chen, Wei, Connell, John, Dalgeorgou, Chrysoula, de Boer, Anthonius, Drenos, Fotios, Elbers, Clara C, Fang, James C, Fox, Caroline S, Frackelton, Edward C, Fuchs, Barry, Furlong, Clement E, Gibson, Quince, Gieger, Christian, Goel, Anuj, Grobbee, Diederik E, Hastie, Claire, Howard, Philip J, Huang, Guan-Hua, Johnson, W Craig, Li, Qing, Kleber, Marcus E, Klein, Barbara EK, Klein, Ronald, Kooperberg, Charles, Ky, Bonnie, LaCroix, Andrea, Lanken, Paul, Lathrop, Mark, Li, Mingyao, Marshall, Vanessa, Melander, Olle, Mentch, Frank D, Meyer, Nuala J, Monda, Keri L, Montpetit, Alexandre, Murugesan, Gurunathan, Nakayama, Karen, Nondahl, Dave, Onipinla, Abiodun, Rafelt, Suzanne, Newhouse, Stephen J, Otieno, F George, Patel, Sanjey R, Putt, Mary E, Rodriguez, Santiago, Safa, Radwan N, Sawyer, Douglas B, Schreiner, Pamela J, Simpson, Claire, Sivapalaratnam, Suthesh, Srinivasan, Sathanur R, and Suver, Christine

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Adult, Black or African American, Asian People, Body Height, Cardiovascular System, Female, Gene Frequency, Genetic Heterogeneity, Genetic Loci, Genome-Wide Association Study, Hispanic or Latino, Humans, Interleukin-11, Male, Polymorphism, Single Nucleotide, Smad3 Protein, White People, Hugh Watkins on behalf of PROCARDIS, Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 SNPs across approximately 2000 loci, we evaluated the association of common and uncommon SNPs with adult height in 114,223 individuals from 47 studies and six ethnicities. A total of 64 loci contained a SNP associated with height at array-wide significance (p < 2.4 × 10(-6)), with 42 loci surpassing the conventional genome-wide significance threshold (p < 5 × 10(-8)). Common variants with minor allele frequencies greater than 5% were observed to be associated with height in 37 previously reported loci. In individuals of European ancestry, uncommon SNPs in IL11 and SMAD3, which would not be genotyped with the use of standard genome-wide genotyping arrays, were strongly associated with height (p < 3 × 10(-11)). Conditional analysis within associated regions revealed five additional variants associated with height independent of lead SNPs within the locus, suggesting allelic heterogeneity. Although underpowered to replicate findings from individuals of European ancestry, the direction of effect of associated variants was largely consistent in African American, South Asian, and Hispanic populations. Overall, we show that dense coverage of genes for uncommon SNPs, coupled with large-scale meta-analysis, can successfully identify additional variants associated with a common complex trait.

Published
2011

237. Advancing Space Science Requires NASA Support for Coordination Between the Science Mission Directorate Communities

Author

Mandt, Kathleen, primary, Rymer, Abigail, additional, Kalirai, Jason, additional, Allen, Robert, additional, Cocoros, Alice, additional, Stevenson, Kevin, additional, Hurley, Dana, additional, Lisse, Carey, additional, Runyon, Kirby, additional, Dalba, Paul, additional, Domagal-Goldman, Shawn, additional, Kane, Stephen R., additional, Brandt, Pontus, additional, Provornikova, Elena, additional, Meadows, Victoria, additional, Vervack, Ronald, additional, Roberge, Aki, additional, Dong, Chuanfei, additional, Arney, Giada, additional, Bodewits, Dennis, additional, Simon, Amy, additional, Rivera-Valentine, Edgard, additional, Soderland, Krista, additional, Diniega, Serina, additional, Bayless, Amanda, additional, Richey, Christina, additional, Becker, Tracy, additional, Schmidt, Britney, additional, Val-Borro, Miguel de, additional, Milam, Stefanie, additional, Quick, Lynnae, additional, Turner, Neal, additional, Angerhausen, Daniel, additional, Dyar, Darby, additional, Samara, Marilia, additional, Hendrix, Amanda, additional, Soto, Alejandro, additional, Miller, Kelly, additional, Mahaffy, Paul, additional, Quintana, Elisa, additional, Bergin, Edwin A., additional, Vidaurri, Monica R., additional, Bryne, Paul, additional, Danchi, William C., additional, Mayorga, Laura, additional, Marley, Mark S., additional, Barnes, Rory, additional, Genio, Anthony D. Del, additional, Plavchan, Peter, additional, Turnbull, Margaret C., additional, Gelino, Dawn M., additional, Wright, Jason T., additional, Meyer, Michael R., additional, Pepper, Joshua, additional, Dragomir, Diana, additional, Garcia-Sage, Katherine, additional, Solmaz, Arif, additional, Heavens, Nicholas, additional, Beatty, Thomas, additional, Redfield, Seth, additional, Melis, Carl, additional, Stapelfeldt, Karl, additional, Drake, Jeremy, additional, Lovato, Kylie, additional, Hasegawa, Yasuhiro, additional, Smith, Erin C., additional, Curry, Shannon, additional, Jenkins, Jon M., additional, Jackson, Brian, additional, Cartwright, Richard, additional, Cohen, Ian J., additional, Retherford, Kurt, additional, Pinella-Alonso, Noemi, additional, Paganelli, Flora, additional, Accomazzi, Alberto, additional, Fortney, Jonathan, additional, Nikoukar, Romina, additional, and Chen, Thomas Y., additional

Published
2023
Full Text
View/download PDF

238. Redefining the Edge:: Life Without Levees

Author

Smith, Erin

Subjects
places, placemaking, architecture, environment, landscape, urban design, public realm, planning, design, volume 21, issue 1, Recovering, erin, smith, levees, redefining, edge
Published
2009

239. The James Webb Space Telescope Mission

Author

Gardner, Jonathan P., primary, Mather, John C., additional, Abbott, Randy, additional, Abell, James S., additional, Abernathy, Mark, additional, Abney, Faith E., additional, Abraham, John G., additional, Abraham, Roberto, additional, Abul-Huda, Yasin M., additional, Acton, Scott, additional, Adams, Cynthia K., additional, Adams, Evan, additional, Adler, David S., additional, Adriaensen, Maarten, additional, Aguilar, Jonathan Albert, additional, Ahmed, Mansoor, additional, Ahmed, Nasif S., additional, Ahmed, Tanjira, additional, Albat, Rüdeger, additional, Albert, Loïc, additional, Alberts, Stacey, additional, Aldridge, David, additional, Allen, Mary Marsha, additional, Allen, Shaune S., additional, Altenburg, Martin, additional, Altunc, Serhat, additional, Alvarez, Jose Lorenzo, additional, Álvarez-Márquez, Javier, additional, de Oliveira, Catarina Alves, additional, Ambrose, Leslie L., additional, Anandakrishnan, Satya M., additional, Andersen, Gregory C., additional, Anderson, Harry James, additional, Anderson, Jay, additional, Anderson, Kristen, additional, Anderson, Sara M., additional, Aprea, Julio, additional, Archer, Benita J., additional, Arenberg, Jonathan W., additional, Argyriou, Ioannis, additional, Arribas, Santiago, additional, Artigau, Étienne, additional, Arvai, Amanda Rose, additional, Atcheson, Paul, additional, Atkinson, Charles B., additional, Averbukh, Jesse, additional, Aymergen, Cagatay, additional, Bacinski, John J., additional, Baggett, Wayne E., additional, Bagnasco, Giorgio, additional, Baker, Lynn L., additional, Balzano, Vicki Ann, additional, Banks, Kimberly A., additional, Baran, David A., additional, Barker, Elizabeth A., additional, Barrett, Larry K., additional, Barringer, Bruce O., additional, Barto, Allison, additional, Bast, William, additional, Baudoz, Pierre, additional, Baum, Stefi, additional, Beatty, Thomas G., additional, Beaulieu, Mathilde, additional, Bechtold, Kathryn, additional, Beck, Tracy, additional, Beddard, Megan M., additional, Beichman, Charles, additional, Bellagama, Larry, additional, Bely, Pierre, additional, Berger, Timothy W., additional, Bergeron, Louis E., additional, Bernier, Antoine-Darveau, additional, Bertch, Maria D., additional, Beskow, Charlotte, additional, Betz, Laura E., additional, Biagetti, Carl P., additional, Birkmann, Stephan, additional, Bjorklund, Kurt F., additional, Blackwood, James D., additional, Blazek, Ronald Paul, additional, Blossfeld, Stephen, additional, Bluth, Marcel, additional, Boccaletti, Anthony, additional, Boegner Jr, Martin E., additional, Bohlin, Ralph C., additional, Boia, John Joseph, additional, Böker, Torsten, additional, Bonaventura, N., additional, Bond, Nicholas A., additional, Bosley, Kari Ann, additional, Boucarut, Rene A., additional, Bouchet, Patrice, additional, Bouwman, Jeroen, additional, Bower, Gary, additional, Bowers, Ariel S., additional, Bowers, Charles W., additional, Boyce, Leslye A., additional, Boyer, Christine T., additional, Boyer, Martha L., additional, Boyer, Michael, additional, Boyer, Robert, additional, Bradley, Larry D., additional, Brady, Gregory R., additional, Brandl, Bernhard R., additional, Brannen, Judith L., additional, Breda, David, additional, Bremmer, Harold G., additional, Brennan, David, additional, Bresnahan, Pamela A., additional, Bright, Stacey N., additional, Broiles, Brian J., additional, Bromenschenkel, Asa, additional, Brooks, Brian H., additional, Brooks, Keira J., additional, Brown, Bob, additional, Brown, Bruce, additional, Brown, Thomas M., additional, Bruce, Barry W., additional, Bryson, Jonathan G., additional, Bujanda, Edwin D., additional, Bullock, Blake M., additional, Bunker, A. J., additional, Bureo, Rafael, additional, Burt, Irving J., additional, Bush, James Aaron, additional, Bushouse, Howard A., additional, Bussman, Marie C., additional, Cabaud, Olivier, additional, Cale, Steven, additional, Calhoon, Charles D., additional, Calvani, Humberto, additional, Canipe, Alicia M., additional, Caputo, Francis M., additional, Cara, Mihai, additional, Carey, Larkin, additional, Case, Michael Eli, additional, Cesari, Thaddeus, additional, Cetorelli, Lee D., additional, Chance, Don R., additional, Chandler, Lynn, additional, Chaney, Dave, additional, Chapman, George N., additional, Charlot, S., additional, Chayer, Pierre, additional, Cheezum, Jeffrey I., additional, Chen, Bin, additional, Chen, Christine H., additional, Cherinka, Brian, additional, Chichester, Sarah C., additional, Chilton, Zachary S., additional, Chittiraibalan, Dharini, additional, Clampin, Mark, additional, Clark, Charles R., additional, Clark, Kerry W., additional, Clark, Stephanie M., additional, Claybrooks, Edward E., additional, Cleveland, Keith A., additional, Cohen, Andrew L., additional, Cohen, Lester M., additional, Colón, Knicole D., additional, Coleman, Benee L., additional, Colina, Luis, additional, Comber, Brian J., additional, Comeau, Thomas M., additional, Comer, Thomas, additional, Reis, Alain Conde, additional, Connolly, Dennis C., additional, Conroy, Kyle E., additional, Contos, Adam R., additional, Contreras, James, additional, Cook, Neil J., additional, Cooper, James L., additional, Cooper, Rachel Aviva, additional, Correia, Michael F., additional, Correnti, Matteo, additional, Cossou, Christophe, additional, Costanza, Brian F., additional, Coulais, Alain, additional, Cox, Colin R., additional, Coyle, Ray T., additional, Cracraft, Misty M., additional, Crew, Keith A., additional, Curtis, Gary J., additional, Cusveller, Bianca, additional, Maciel, Cleyciane Da Costa, additional, Dailey, Christopher T., additional, Daugeron, Frédéric, additional, Davidson, Greg S., additional, Davies, James E., additional, Davis, Katherine Anne, additional, Davis, Michael S., additional, Day, Ratna, additional, de Chambure, Daniel, additional, de Jong, Pauline, additional, De Marchi, Guido, additional, Dean, Bruce H., additional, Decker, John E., additional, Delisa, Amy S., additional, Dell, Lawrence C., additional, Dellagatta, Gail, additional, Dembinska, Franciszka, additional, Demosthenes, Sandor, additional, Dencheva, Nadezhda M., additional, Deneu, Philippe, additional, DePriest, William W., additional, Deschenes, Jeremy, additional, Dethienne, Nathalie, additional, Detre, Örs Hunor, additional, Diaz, Rosa Izela, additional, Dicken, Daniel, additional, DiFelice, Audrey S., additional, Dillman, Matthew, additional, Disharoon, Maureen O., additional, Dixon, William V., additional, Doggett, Jesse B., additional, Dominguez, Keisha L., additional, Donaldson, Thomas S., additional, Doria-Warner, Cristina M., additional, Santos, Tony Dos, additional, Doty, Heather, additional, Douglas, Jr, Robert E., additional, Doyon, René, additional, Dressler, Alan, additional, Driggers, Jennifer, additional, Driggers, Phillip A., additional, Dunn, Jamie L., additional, DuPrie, Kimberly C., additional, Dupuis, Jean, additional, Durning, John, additional, Dutta, Sanghamitra B., additional, Earl, Nicholas M., additional, Eccleston, Paul, additional, Ecobichon, Pascal, additional, Egami, Eiichi, additional, Ehrenwinkler, Ralf, additional, Eisenhamer, Jonathan D., additional, Eisenhower, Michael, additional, Eisenstein, Daniel J., additional, El Hamel, Zaky, additional, Elie, Michelle L., additional, Elliott, James, additional, Elliott, Kyle Wesley, additional, Engesser, Michael, additional, Espinoza, Néstor, additional, Etienne, Odessa, additional, Etxaluze, Mireya, additional, Evans, Leah, additional, Fabreguettes, Luce, additional, Falcolini, Massimo, additional, Falini, Patrick R., additional, Fatig, Curtis, additional, Feeney, Matthew, additional, Feinberg, Lee D., additional, Fels, Raymond, additional, Ferdous, Nazma, additional, Ferguson, Henry C., additional, Ferrarese, Laura, additional, Ferreira, Marie-Héléne, additional, Ferruit, Pierre, additional, Ferry, Malcolm, additional, Filippazzo, Joseph Charles, additional, Firre, Daniel, additional, Fix, Mees, additional, Flagey, Nicolas, additional, Flanagan, Kathryn A., additional, Fleming, Scott W., additional, Florian, Michael, additional, Flynn, James R., additional, Foiadelli, Luca, additional, Fontaine, Mark R., additional, Fontanella, Erin Marie, additional, Forshay, Peter Randolph, additional, Fortner, Elizabeth A., additional, Fox, Ori D., additional, Framarini, Alexandro P., additional, Francisco, John I., additional, Franck, Randy, additional, Franx, Marijn, additional, Franz, David E., additional, Friedman, Scott D., additional, Friend, Katheryn E., additional, Frost, James R., additional, Fu, Henry, additional, Fullerton, Alexander W., additional, Gaillard, Lionel, additional, Galkin, Sergey, additional, Gallagher, Ben, additional, Galyer, Anthony D., additional, García Marín, Macarena, additional, Gardner, Lisa E., additional, Garland, Dennis, additional, Garrett, Bruce Albert, additional, Gasman, Danny, additional, Gáspár, András, additional, Gastaud, René, additional, Gaudreau, Daniel, additional, Gauthier, Peter Timothy, additional, Geers, Vincent, additional, Geithner, Paul H., additional, Gennaro, Mario, additional, Gerber, John, additional, Gereau, John C., additional, Giampaoli, Robert, additional, Giardino, Giovanna, additional, Gibbons, Paul C., additional, Gilbert, Karoline, additional, Gilman, Larry, additional, Girard, Julien H., additional, Giuliano, Mark E., additional, Gkountis, Konstantinos, additional, Glasse, Alistair, additional, Glassmire, Kirk Zachary, additional, Glauser, Adrian Michael, additional, Glazer, Stuart D., additional, Goldberg, Joshua, additional, Golimowski, David A., additional, Gonzaga, Shireen P., additional, Gordon, Karl D., additional, Gordon, Shawn J., additional, Goudfrooij, Paul, additional, Gough, Michael J., additional, Graham, Adrian J., additional, Grau, Christopher M., additional, Green, Joel David, additional, Greene, Gretchen R., additional, Greene, Thomas P., additional, Greenfield, Perry E., additional, Greenhouse, Matthew A., additional, Greve, Thomas R., additional, Greville, Edgar M., additional, Grimaldi, Stefano, additional, Groe, Frank E., additional, Groebner, Andrew, additional, Grumm, David M., additional, Grundy, Timothy, additional, Güdel, Manuel, additional, Guillard, Pierre, additional, Guldalian, John, additional, Gunn, Christopher A., additional, Gurule, Anthony, additional, Gutman, Irvin Meyer, additional, Guy, Paul D., additional, Guyot, Benjamin, additional, Hack, Warren J., additional, Haderlein, Peter, additional, Hagan, James B., additional, Hagedorn, Andria, additional, Hainline, Kevin, additional, Haley, Craig, additional, Hami, Maryam, additional, Hamilton, Forrest Clifford, additional, Hammann, Jeffrey, additional, Hammel, Heidi B., additional, Hanley, Christopher J., additional, Hansen, Carl August, additional, Hardy, Bruce, additional, Harnisch, Bernd, additional, Harr, Michael Hunter, additional, Harris, Pamela, additional, Hart, Jessica Ann, additional, Hartig, George F., additional, Hasan, Hashima, additional, Hashim, Kathleen Marie, additional, Hashimoto, Ryan, additional, Haskins, Sujee J., additional, Hawkins, Robert Edward, additional, Hayden, Brian, additional, Hayden, William L., additional, Healy, Mike, additional, Hecht, Karen, additional, Heeg, Vince J., additional, Hejal, Reem, additional, Helm, Kristopher A., additional, Hengemihle, Nicholas J., additional, Henning, Thomas, additional, Henry, Alaina, additional, Henry, Ronald L., additional, Henshaw, Katherine, additional, Hernandez, Scarlin, additional, Herrington, Donald C., additional, Heske, Astrid, additional, Hesman, Brigette Emily, additional, Hickey, David L., additional, Hilbert, Bryan N., additional, Hines, Dean C., additional, Hinz, Michael R., additional, Hirsch, Michael, additional, Hitcho, Robert S., additional, Hodapp, Klaus, additional, Hodge, Philip E., additional, Hoffman, Melissa, additional, Holfeltz, Sherie T., additional, Holler, Bryan Jason, additional, Hoppa, Jennifer Rose, additional, Horner, Scott, additional, Howard, Joseph M., additional, Howard, Richard J., additional, Huber, Jean M., additional, Hunkeler, Joseph S., additional, Hunter, Alexander, additional, Hunter, David Gavin, additional, Hurd, Spencer W., additional, Hurst, Brendan J., additional, Hutchings, John B., additional, Hylan, Jason E., additional, Ignat, Luminita Ilinca, additional, Illingworth, Garth, additional, Irish, Sandra M., additional, Isaacs III, John C., additional, Jackson Jr, Wallace C., additional, Jaffe, Daniel T., additional, Jahic, Jasmin, additional, Jahromi, Amir, additional, Jakobsen, Peter, additional, James, Bryan, additional, James, John C., additional, James, LeAndrea Rae, additional, Jamieson, William Brian, additional, Jandra, Raymond D., additional, Jayawardhana, Ray, additional, Jedrzejewski, Robert, additional, Jeffers, Basil S., additional, Jensen, Peter, additional, Joanne, Egges, additional, Johns, Alan T., additional, Johnson, Carl A., additional, Johnson, Eric L., additional, Johnson, Patricia, additional, Johnson, Phillip Stephen, additional, Johnson, Thomas K., additional, Johnson, Timothy W., additional, Johnstone, Doug, additional, Jollet, Delphine, additional, Jones, Danny P., additional, Jones, Gregory S., additional, Jones, Olivia C., additional, Jones, Ronald A., additional, Jones, Vicki, additional, Jordan, Ian J., additional, Jordan, Margaret E., additional, Jue, Reginald, additional, Jurkowski, Mark H., additional, Justis, Grant, additional, Justtanont, Kay, additional, Kaleida, Catherine C., additional, Kalirai, Jason S., additional, Kalmanson, Phillip Cabrales, additional, Kaltenegger, Lisa, additional, Kammerer, Jens, additional, Kan, Samuel K., additional, Kanarek, Graham Childs, additional, Kao, Shaw-Hong, additional, Karakla, Diane M., additional, Karl, Hermann, additional, Kassin, Susan A., additional, Kauffman, David D., additional, Kavanagh, Patrick, additional, Kelley, Leigh L., additional, Kelly, Douglas M., additional, Kendrew, Sarah, additional, Kennedy, Herbert V., additional, Kenny, Deborah A., additional, Keski-Kuha, Ritva A., additional, Keyes, Charles D., additional, Khan, Ali, additional, Kidwell, Richard C., additional, Kimble, Randy A., additional, King, James S., additional, King, Richard C., additional, Kinzel, Wayne M., additional, Kirk, Jeffrey R., additional, Kirkpatrick, Marc E., additional, Klaassen, Pamela, additional, Klingemann, Lana, additional, Klintworth, Paul U., additional, Knapp, Bryan Adam, additional, Knight, Scott, additional, Knollenberg, Perry J., additional, Knutsen, Daniel Mark, additional, Koehler, Robert, additional, Koekemoer, Anton M., additional, Kofler, Earl T., additional, Kontson, Vicki L., additional, Kovacs, Aiden Rose, additional, Kozhurina-Platais, Vera, additional, Krause, Oliver, additional, Kriss, Gerard A., additional, Krist, John, additional, Kristoffersen, Monica R., additional, Krogel, Claudia, additional, Krueger, Anthony P., additional, Kulp, Bernard A., additional, Kumari, Nimisha, additional, Kwan, Sandy W., additional, Kyprianou, Mark, additional, Labador, Aurora Gadiano, additional, Labiano, Álvaro, additional, Lafrenière, David, additional, Lagage, Pierre-Olivier, additional, Laidler, Victoria G., additional, Laine, Benoit, additional, Laird, Simon, additional, Lajoie, Charles-Philippe, additional, Lallo, Matthew D., additional, Lam, May Yen, additional, LaMassa, Stephanie Marie, additional, Lambros, Scott D., additional, Lampenfield, Richard Joseph, additional, Lander, Matthew Ed, additional, Langston, James Hutton, additional, Larson, Kirsten, additional, Larson, Melora, additional, LaVerghetta, Robert Joseph, additional, Law, David R., additional, Lawrence, Jon F., additional, Lee, David W., additional, Lee, Janice, additional, Lee, Yat-Ning Paul, additional, Leisenring, Jarron, additional, Leveille, Michael Dunlap, additional, Levenson, Nancy A., additional, Levi, Joshua S., additional, Levine, Marie B., additional, Lewis, Dan, additional, Lewis, Jake, additional, Lewis, Nikole, additional, Libralato, Mattia, additional, Lidon, Norbert, additional, Liebrecht, Paula Louisa, additional, Lightsey, Paul, additional, Lilly, Simon, additional, Lim, Frederick C., additional, Lim, Pey Lian, additional, Ling, Sai-Kwong, additional, Link, Lisa J., additional, Link, Miranda Nicole, additional, Lipinski, Jamie L., additional, Liu, XiaoLi, additional, Lo, Amy S., additional, Lobmeyer, Lynette, additional, Logue, Ryan M., additional, Long, Chris A., additional, Long, Douglas R., additional, Long, Ilana D., additional, Long, Knox S., additional, López-Caniego, Marcos, additional, Lotz, Jennifer M., additional, Love-Pruitt, Jennifer M., additional, Lubskiy, Michael, additional, Luers, Edward B., additional, Luetgens, Robert A., additional, Luevano, Annetta J., additional, G. Flores Lui, Sarah Marie, additional, Lund III, James M., additional, Lundquist, Ray A., additional, Lunine, Jonathan, additional, Lützgendorf, Nora, additional, Lynch, Richard J., additional, MacDonald, Alex J., additional, MacDonald, Kenneth, additional, Macias, Matthew J., additional, Macklis, Keith I., additional, Maghami, Peiman, additional, Maharaja, Rishabh Y., additional, Maiolino, Roberto, additional, Makrygiannis, Konstantinos G., additional, Malla, Sunita Giri, additional, Malumuth, Eliot M., additional, Manjavacas, Elena, additional, Marini, Andrea, additional, Marrione, Amanda, additional, Marston, Anthony, additional, Martel, André R, additional, Martin, Didier, additional, Martin, Peter G., additional, Martinez, Kristin L., additional, Maschmann, Marc, additional, Masci, Gregory L., additional, Masetti, Margaret E., additional, Maszkiewicz, Michael, additional, Matthews, Gary, additional, Matuskey, Jacob E., additional, McBrayer, Glen A., additional, McCarthy, Donald W., additional, McCaughrean, Mark J., additional, McClare, Leslie A., additional, McClare, Michael D., additional, McCloskey, John C., additional, McClurg, Taylore D., additional, McCoy, Martin, additional, McElwain, Michael W., additional, McGregor, Roy D., additional, McGuffey, Douglas B., additional, McKay, Andrew G., additional, McKenzie, William K., additional, McLean, Brian, additional, McMaster, Matthew, additional, McNeil, Warren, additional, De Meester, Wim, additional, Mehalick, Kimberly L., additional, Meixner, Margaret, additional, Meléndez, Marcio, additional, Menzel, Michael P., additional, Menzel, Michael T., additional, Merz, Matthew, additional, Mesterharm, David D., additional, Meyer, Michael R., additional, Meyett, Michele L., additional, Meza, Luis E., additional, Midwinter, Calvin, additional, Milam, Stefanie N., additional, Miller, Jay Todd, additional, Miller, William C., additional, Miskey, Cherie L., additional, Misselt, Karl, additional, Mitchell, Eileen P., additional, Mohan, Martin, additional, Montoya, Emily E., additional, Moran, Michael J., additional, Morishita, Takahiro, additional, Moro-Martín, Amaya, additional, Morrison, Debra L., additional, Morrison, Jane, additional, Morse, Ernie C., additional, Moschos, Michael, additional, Moseley, S. H., additional, Mosier, Gary E., additional, Mosner, Peter, additional, Mountain, Matt, additional, Muckenthaler, Jason S., additional, Mueller, Donald G., additional, Mueller, Migo, additional, Muhiem, Daniella, additional, Mühlmann, Prisca, additional, Mullally, Susan Elizabeth, additional, Mullen, Stephanie M., additional, Munger, Alan J, additional, Murphy, Jess, additional, Murray, Katherine T., additional, Muzerolle, James C., additional, Mycroft, Matthew, additional, Myers, Andrew, additional, Myers, Carey R., additional, R. Myers, Fred Richard, additional, Myers, Richard, additional, Myrick, Kaila, additional, Nagle, IV, Adrian F., additional, Nayak, Omnarayani, additional, Naylor, Bret, additional, Neff, Susan G., additional, Nelan, Edmund P., additional, Nella, John, additional, Nguyen, Duy Tuong, additional, Nguyen, Michael N., additional, Nickson, Bryony, additional, Nidhiry, John Joseph, additional, Niedner, Malcolm B., additional, Nieto-Santisteban, Maria, additional, Nikolov, Nikolay K., additional, Nishisaka, Mary Ann, additional, Noriega-Crespo, Alberto, additional, Nota, Antonella, additional, O’Mara, Robyn C., additional, Oboryshko, Michael, additional, O’Brien, Marcus B., additional, Ochs, William R., additional, Offenberg, Joel D., additional, Ogle, Patrick Michael, additional, Ohl, Raymond G., additional, Olmsted, Joseph Hamden, additional, Osborne, Shannon Barbara, additional, O’Shaughnessy, Brian Patrick, additional, Östlin, Göran, additional, O’Sullivan, Brian, additional, Otor, O. Justin, additional, Ottens, Richard, additional, Ouellette, Nathalie N.-Q., additional, Outlaw, Daria J., additional, Owens, Beverly A., additional, Pacifici, Camilla, additional, Page, James Christophe, additional, Paranilam, James G., additional, Park, Sang, additional, Parrish, Keith A., additional, Paschal, Laura, additional, Patapis, Polychronis, additional, Patel, Jignasha, additional, Patrick, Keith, additional, Pattishall Jr, Robert A., additional, Paul, Douglas William, additional, Paul, Shirley J., additional, Pauly, Tyler Andrew, additional, Pavlovsky, Cheryl M., additional, Peña-Guerrero, Maria, additional, Pedder, Andrew H., additional, Peek, Matthew Weldon, additional, Pelham, Patricia A., additional, Penanen, Konstantin, additional, Perriello, Beth A., additional, Perrin, Marshall D., additional, Perrine, Richard F., additional, Perrygo, Chuck, additional, Peslier, Muriel, additional, Petach, Michael, additional, Peterson, Karla A., additional, Pfarr, Tom, additional, Pierson, James M., additional, Pietraszkiewicz, Martin, additional, Pilchen, Guy, additional, Pipher, Judy L., additional, Pirzkal, Norbert, additional, Pitman, Joseph T., additional, Player, Danielle M., additional, Plesha, Rachel, additional, Plitzke, Anja, additional, Pohner, John A., additional, Poletis, Karyn Konstantin, additional, Pollizzi, Joseph A., additional, Polster, Ethan, additional, Pontius, James T., additional, Pontoppidan, Klaus, additional, Porges, Susana C., additional, Potter, Gregg D., additional, Prescott, Stephen, additional, Proffitt, Charles R., additional, Pueyo, Laurent, additional, Quispe Neira, Irma Aracely, additional, Radich, Armando, additional, Rager, Reiko T., additional, Rameau, Julien, additional, Ramey, Deborah D., additional, Alarcon, Rafael Ramos, additional, Rampini, Riccardo, additional, Rapp, Robert, additional, Rashford, Robert A., additional, Rauscher, Bernard J., additional, Ravindranath, Swara, additional, Rawle, Timothy, additional, Rawlings, Tynika N., additional, Ray, Tom, additional, Regan, Michael W., additional, Rehm, Brian, additional, Rehm, Kenneth D., additional, Reid, Neill, additional, Reis, Carl A., additional, Renk, Florian, additional, Reoch, Tom B., additional, Ressler, Michael, additional, Rest, Armin W., additional, Reynolds, Paul J., additional, Richon, Joel G., additional, Richon, Karen V., additional, Ridgaway, Michael, additional, Riedel, Adric Richard, additional, Rieke, George H., additional, Rieke, Marcia J., additional, Rifelli, Richard E., additional, Rigby, Jane R., additional, Riggs, Catherine S., additional, Ringel, Nancy J., additional, Ritchie, Christine E., additional, Rix, Hans-Walter, additional, Robberto, Massimo, additional, Robinson, Gregory L., additional, Robinson, Michael S., additional, Robinson, Orion, additional, Rock, Frank W., additional, Rodriguez, David R., additional, del Pino, Bruno Rodríguez, additional, Roellig, Thomas, additional, Rohrbach, Scott O., additional, Roman, Anthony J., additional, Romelfanger, Frederick J., additional, Romo Jr, Felipe P., additional, Rosales, Jose J., additional, Rose, Perry, additional, Roteliuk, Anthony F., additional, Roth, Marc N., additional, Rothwell, Braden Quinn, additional, Rouzaud, Sylvain, additional, Rowe, Jason, additional, Rowlands, Neil, additional, Roy, Arpita, additional, Royer, Pierre, additional, Rui, Chunlei, additional, Rumler, Peter, additional, Rumpl, William, additional, Russ, Melissa L., additional, Ryan, Michael B., additional, Ryan, Richard M., additional, Saad, Karl, additional, Sabata, Modhumita, additional, Sabatino, Rick, additional, Sabbi, Elena, additional, Sabelhaus, Phillip A., additional, Sabia, Stephen, additional, Sahu, Kailash C., additional, Saif, Babak N., additional, Salvignol, Jean-Christophe, additional, Samara-Ratna, Piyal, additional, Samuelson, Bridget S., additional, Sanders, Felicia A., additional, Sappington, Bradley, additional, Sargent, B. A., additional, Sauer, Arne, additional, Savadkin, Bruce J., additional, Sawicki, Marcin, additional, Schappell, Tina M., additional, Scheffer, Caroline, additional, Scheithauer, Silvia, additional, Scherer, Ron, additional, Schiff, Conrad, additional, Schlawin, Everett, additional, Schmeitzky, Olivier, additional, Schmitz, Tyler S., additional, Schmude, Donald J., additional, Schneider, Analyn, additional, Schreiber, Jürgen, additional, Schroeven-Deceuninck, Hilde, additional, Schultz, John J., additional, Schwab, Ryan, additional, Schwartz, Curtis H., additional, Scoccimarro, Dario, additional, Scott, John F., additional, Scott, Michelle B., additional, Seaton, Bonita L., additional, Seely, Bruce S., additional, Seery, Bernard, additional, Seidleck, Mark, additional, Sembach, Kenneth, additional, Shanahan, Clare Elizabeth, additional, Shaughnessy, Bryan, additional, Shaw, Richard A., additional, Shay, Christopher Michael, additional, Sheehan, Even, additional, Sheth, Kartik, additional, Shih, Hsin-Yi, additional, Shivaei, Irene, additional, Siegel, Noah, additional, Sienkiewicz, Matthew G., additional, Simmons, Debra D., additional, Simon, Bernard P., additional, Sirianni, Marco, additional, Sivaramakrishnan, Anand, additional, Slade, Jeffrey E., additional, Sloan, G. C., additional, Slocum, Christine E., additional, Slowinski, Steven E., additional, Smith, Corbett T., additional, Smith, Eric P., additional, Smith, Erin C., additional, Smith, Koby, additional, Smith, Robert, additional, Smith, Stephanie J., additional, Smolik, John L., additional, Soderblom, David R., additional, Sohn, Sangmo Tony, additional, Sokol, Jeff, additional, Sonneborn, George, additional, Sontag, Christopher D., additional, Sooy, Peter R., additional, Soummer, Remi, additional, Southwood, Dana M., additional, Spain, Kay, additional, Sparmo, Joseph, additional, Speer, David T., additional, Spencer, Richard, additional, Sprofera, Joseph D., additional, Stallcup, Scott S., additional, Stanley, Marcia K., additional, Stansberry, John A., additional, Stark, Christopher C., additional, Starr, Carl W., additional, Stassi, Diane Y., additional, Steck, Jane A., additional, Steeley, Christine D., additional, Stephens, Matthew A., additional, Stephenson, Ralph J., additional, Stewart, Alphonso C., additional, Stiavelli, Massimo, additional, Jr, Hervey Stockman, additional, Strada, Paolo, additional, Straughn, Amber N., additional, Streetman, Scott, additional, Strickland, David Kendal, additional, Strobele, Jingping F., additional, Stuhlinger, Martin, additional, Stys, Jeffrey Edward, additional, Such, Miguel, additional, Sukhatme, Kalyani, additional, Sullivan, Joseph F., additional, Sullivan, Pamela C., additional, Sumner, Sandra M., additional, Sun, Fengwu, additional, Sunnquist, Benjamin Dale, additional, Swade, Daryl Allen, additional, Swam, Michael S., additional, Swenton, Diane F., additional, Swoish, Robby A., additional, Tam Litten, Oi In, additional, Tamas, Laszlo, additional, Tao, Andrew, additional, Taylor, David K., additional, Taylor, Joanna M., additional, Plate, Maurice te, additional, Van Tea, Mason, additional, Teague, Kelly K., additional, Telfer, Randal C., additional, Temim, Tea, additional, Texter, Scott C., additional, Thatte, Deepashri G., additional, Thompson, Christopher Lee, additional, Thompson, Linda M., additional, Thomson, Shaun R., additional, Thronson, Harley, additional, Tierney, C. M., additional, Tikkanen, Tuomo, additional, Tinnin, Lee, additional, Tippet, William Thomas, additional, Todd, Connor William, additional, Tran, Hien D., additional, Trauger, John, additional, Trejo, Edwin Gregorio, additional, Vinh Truong, Justin Hoang, additional, Tsukamoto, Christine L., additional, Tufail, Yasir, additional, Tumlinson, Jason, additional, Tustain, Samuel, additional, Tyra, Harrison, additional, Ubeda, Leonardo, additional, Underwood, Kelli, additional, Uzzo, Michael A., additional, Vaclavik, Steven, additional, Valenduc, Frida, additional, Valenti, Jeff A., additional, Van Campen, Julie, additional, van de Wetering, Inge, additional, Van Der Marel, Roeland P., additional, van Haarlem, Remy, additional, Vandenbussche, Bart, additional, van Dishoeck, Ewine F., additional, Vanterpool, Dona D., additional, Vernoy, Michael R., additional, Vila Costas, Maria Begoña, additional, Volk, Kevin, additional, Voorzaat, Piet, additional, Voyton, Mark F., additional, Vydra, Ekaterina, additional, Waddy, Darryl J., additional, Waelkens, Christoffel, additional, Wahlgren, Glenn Michael, additional, Walker Jr, Frederick E., additional, Wander, Michel, additional, Warfield, Christine K., additional, Warner, Gerald, additional, Wasiak, Francis C., additional, Wasiak, Matthew F., additional, Wehner, James, additional, Weiler, Kevin R., additional, Weilert, Mark, additional, Weiss, Stanley B., additional, Wells, Martyn, additional, Welty, Alan D., additional, Wheate, Lauren, additional, Wheeler, Thomas P., additional, White, Christy L., additional, Whitehouse, Paul, additional, Whiteleather, Jennifer Margaret, additional, Whitman, William Russell, additional, Williams, Christina C., additional, Willmer, Christopher N. A., additional, Willott, Chris J., additional, Willoughby, Scott P., additional, Wilson, Andrew, additional, Wilson, Debra, additional, Wilson, Donna V., additional, Windhorst, Rogier, additional, Wislowski, Emily Christine, additional, Wolfe, David J., additional, Wolfe, Michael A., additional, Wolff, Schuyler, additional, Wondel, Amancio, additional, Woo, Cindy, additional, Woods, Robert T., additional, Worden, Elaine, additional, Workman, William, additional, Wright, Gillian S., additional, Wu, Carl, additional, Wu, Chi-Rai, additional, Wun, Dakin D., additional, Wymer, Kristen B., additional, Yadetie, Thomas, additional, Yan, Isabelle C., additional, Yang, Keith C., additional, Yates, Kayla L., additional, Yeager, Christopher R., additional, Yerger, Ethan John, additional, Young, Erick T., additional, Young, Gary, additional, Yu, Gene, additional, Yu, Susan, additional, Zak, Dean S., additional, Zeidler, Peter, additional, Zepp, Robert, additional, Zhou, Julia, additional, Zincke, Christian A., additional, Zonak, Stephanie, additional, and Zondag, Elisabeth, additional

Published
2023
Full Text
View/download PDF

242. The James Webb Space Telescope Mission: Optical Telescope Element Design, Development, and Performance

Author

McElwain, Michael W., primary, Feinberg, Lee D., additional, Perrin, Marshall D., additional, Clampin, Mark, additional, Mountain, C. Matt, additional, Lallo, Matthew D., additional, Lajoie, Charles-Philippe, additional, Kimble, Randy A., additional, Bowers, Charles W., additional, Stark, Christopher C., additional, Acton, D. Scott, additional, Atkinson, Charles, additional, Barinek, Beth, additional, Barto, Allison, additional, Basinger, Scott, additional, Beck, Tracy, additional, Bergkoetter, Matthew D., additional, Bluth, Marcel, additional, Boucarut, Rene A., additional, Brady, Gregory R., additional, Brooks, Keira J., additional, Brown, Bob, additional, Byard, John, additional, Carey, Larkin, additional, Carrasquilla, Maria, additional, Chae, Dan, additional, Chaney, David, additional, Chayer, Pierre, additional, Chonis, Taylor, additional, Cohen, Lester, additional, Cole, Helen J., additional, Comeau, Thomas M., additional, Coon, Matthew, additional, Coppock, Eric, additional, Coyle, Laura, additional, Dean, Bruce H., additional, Dziak, Kenneth J., additional, Eisenhower, Michael, additional, Flagey, Nicolas, additional, Franck, Randy, additional, Gallagher, Benjamin, additional, Gilman, Larry, additional, Glassman, Tiffany, additional, Green, Joseph J., additional, Grieco, John, additional, Haase, Shari, additional, Hadjimichael, Theodore J., additional, Hagopian, John G., additional, Hahn, Walter G., additional, Hartig, George F., additional, Havey, Keith A., additional, Hayden, William L., additional, Hellekson, Robert, additional, Hicks, Brian, additional, Holfeltz, Sherie T., additional, Howard, Joseph M., additional, Huguet, Jesse A., additional, Jahne, Brian, additional, Johnson, Leslie A., additional, Johnston, John D., additional, Jurling, Alden S., additional, Kegley, Jeffrey R., additional, Kennard, Scott, additional, Keski-Kuha, Ritva A., additional, Knight, J. Scott, additional, Kulp, Bernard A., additional, Levi, Joshua S., additional, Levine, Marie B., additional, Lightsey, Paul, additional, Luetgens, Robert A., additional, Mather, John C., additional, Matthews, Gary W., additional, McKay, Andrew G., additional, Mehalick, Kimberly I., additional, Meléndez, Marcio, additional, Mosier, Gary E., additional, Murphy, Jess, additional, Nelan, Edmund P., additional, Niedner, Malcolm B., additional, Nol, Darin M., additional, Ohara, Catherine M., additional, Ohl, Raymond G., additional, Olczak, Eugene, additional, Osborne, Shannon B., additional, Park, Sang, additional, Perrygo, Charles, additional, Pueyo, Laurent, additional, Redding, David C., additional, Regan, Michael W., additional, Reynolds, Paul, additional, Rifelli, Rich, additional, Rigby, Jane R., additional, Sabatke, Derek, additional, Saif, Babak N., additional, Scorse, Thomas R., additional, Seo, Byoung-Joon, additional, Shi, Fang, additional, Sigrist, Norbert, additional, Smith, Koby, additional, Smith, J. Scott, additional, Smith, Erin C., additional, Sohn, Sangmo Tony, additional, Stahl, H. Philip, additional, Telfer, Randal, additional, Terlecki, Todd, additional, Texter, Scott C., additional, Van Buren, David, additional, Van Campen, Julie M., additional, Vila, Begoña, additional, Voyton, Mark F., additional, Waldman, Mark, additional, Walker, Chanda B., additional, Weiser, Nick, additional, Wells, Conrad, additional, West, Garrett, additional, Whitman, Tony L., additional, Wolf, Erin, additional, and Zielinski, Thomas P., additional

Published
2023
Full Text
View/download PDF

246. Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast.

Author

Demogines, Ann, Smith, Erin, Kruglyak, Leonid, and Alani, Eric

Subjects
Chromosomes, Fungal, Saccharomyces cerevisiae, Spores, Fungal, DNA Damage, 4-Nitroquinoline-1-oxide, DNA Helicases, Saccharomyces cerevisiae Proteins, Mutagens, Oligonucleotide Array Sequence Analysis, Microbial Sensitivity Tests, Two-Hybrid System Techniques, Crosses, Genetic, DNA Repair, Quantitative Trait, Heritable, Phenotype, Polymorphism, Genetic, Genome, Fungal, Adenosine Triphosphatases, Genetic Linkage, Chromosomes, Fungal, Crosses, Genetic, Genome, Polymorphism, Quantitative Trait, Heritable, Spores, Genetics, Developmental Biology
Abstract

Complex traits typically involve the contribution of multiple gene variants. In this study, we took advantage of a high-density genotyping analysis of the BY (S288c) and RM strains of Saccharomyces cerevisiae and of 123 derived spore progeny to identify the genetic loci that underlie a complex DNA repair sensitivity phenotype. This was accomplished by screening hybrid yeast progeny for sensitivity to a variety of DNA damaging agents. Both the BY and RM strains are resistant to the ultraviolet light-mimetic agent 4-nitroquinoline 1-oxide (4-NQO); however, hybrid progeny from a BYxRM cross displayed varying sensitivities to the drug. We mapped a major quantitative trait locus (QTL), RAD5, and identified the exact polymorphism within this locus responsible for 4-NQO sensitivity. By using a backcrossing strategy along with array-assisted bulk segregant analysis, we identified one other locus, MKT1, and a QTL on Chromosome VII that also link to the hybrid 4-NQO-sensitive phenotype but confer more minor effects. This work suggests an additive model for sensitivity to 4-NQO and provides a strategy for mapping both major and minor QTL that confer background-specific phenotypes. It also provides tools for understanding the effect of genetic background on sensitivity to genotoxic agents.

Published
2008

248. Gene–Environment Interaction in Yeast Gene Expression

Author

Smith, Erin N and Kruglyak, Leonid

Subjects
Genetics, 2.1 Biological and endogenous factors, Aetiology, Environment, GTPase-Activating Proteins, Gene Expression Regulation, Fungal, Gene Regulatory Networks, Genetic Linkage, Models, Genetic, Phenotype, Polymorphism, Genetic, Quantitative Trait Loci, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology
Abstract

The effects of genetic variants on phenotypic traits often depend on environmental and physiological conditions, but such gene-environment interactions are poorly understood. Recently developed approaches that treat transcript abundances of thousands of genes as quantitative traits offer the opportunity to broadly characterize the architecture of gene-environment interactions. We examined the genetic and molecular basis of variation in gene expression between two yeast strains (BY and RM) grown in two different conditions (glucose and ethanol as carbon sources). We observed that most transcripts vary by strain and condition, with 2,996, 3,448, and 2,037 transcripts showing significant strain, condition, and strain-condition interaction effects, respectively. We expression profiled over 100 segregants derived from a cross between BY and RM in both growth conditions, and identified 1,555 linkages for 1,382 transcripts that show significant gene-environment interaction. At the locus level, local linkages, which usually correspond to polymorphisms in cis-regulatory elements, tend to be more stable across conditions, such that they are more likely to show the same effect or the same direction of effect across conditions. Distant linkages, which usually correspond to polymorphisms influencing trans-acting factors, are more condition-dependent, and often show effects in different directions in the two conditions. We characterized a locus that influences expression of many growth-related transcripts, and showed that the majority of the variation is explained by polymorphism in the gene IRA2. The RM allele of IRA2 appears to inhibit Ras/PKA signaling more strongly than the BY allele, and has undergone a change in selective pressure. Our results provide a broad overview of the genetic architecture of gene-environment interactions, as well as a detailed molecular example, and lead to key insights into how the effects of different classes of regulatory variants are modulated by the environment. These observations will guide the design of studies aimed at understanding the genetic basis of complex traits.

Published
2008

250. Telehealth Assessment in Rehabilitation Counseling During the COVID-19 Pandemic.

Author

Pebdani, Roxanna N., Zeidan, Adriana M., Fearn-Smith, Erin M., and Matthews, Lynda R.

Subjects
OCCUPATIONAL roles, COMPUTER software, RESEARCH, RESEARCH methodology, ATTITUDES of medical personnel, INTERNET, REHABILITATION counselors, MEDICAL care use, DESCRIPTIVE statistics, QUESTIONNAIRES, TECHNOLOGY, DATA analysis software, TELEMEDICINE, REHABILITATION counseling, COVID-19 pandemic
Abstract

Research has shown that using telehealth for rehabilitation assessment can be an effective approach. The COVID-19 pandemic and subsequent lockdowns led to many rehabilitation counselors pivoting to telehealth assessment with their clients. This study explores rehabilitation counselors' use of rehabilitation assessments and telehealth since the beginning of the COVID-19 pandemic. Using a mixed-methods approach, the researchers analyzed data from 41 rehabilitation counselors across Australia. Participants were asked which measures they used prior to the pandemic, how their use of the measures changed during telehealth, and how their work changed due to the COVID-19 pandemic. The Depression Anxiety Stress Scales and the Occupational Search Inventory were the most commonly used tests. Theoretical analysis demonstrated that participants utilized tests based on their usefulness in comprehensive assessment and rehabilitation planning, for engaging the client in the assessment process, out of necessity (mandated tests), and due to attributes of the test the counselor valued. Participants described the impact of COVID-19 on assessment practice, demonstrating that despite challenges to telehealth, there were also benefits and that assessment measures could be altered for use in telehealth. Although telehealth had an impact on how rehabilitation counselors provided assessments, many found ways to make it work at a distance. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results