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201. Treatment and survival diversities in different forms of ILD in Germany - EXCITING registry

Author

Kreuter, Michael, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Maqhuzu, Phillen, additional, Schwarzkopf, Larissa, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Jürgen, additional, Kauschka, Dagmar, additional, Günther, Andreas, additional, Herth, Felix J. F., additional, and Markart, Philipp, additional

Published
2019
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210. Pulmonary hypertension due to lung diseases: Updated recommendations from the Cologne Consensus Conference 2018

Author

Olschewski, Horst, primary, Behr, Jürgen, additional, Bremer, Hinrich, additional, Claussen, Martin, additional, Douschan, Philipp, additional, Halank, Michael, additional, Held, Matthias, additional, Hoeper, Marius M., additional, Holt, Stephan, additional, Klose, Hans, additional, Krüger, Stephan, additional, Lange, Tobias J., additional, Reichenberger, Frank, additional, Skowasch, Dirk, additional, Ulrich, Silvia, additional, Wilkens, Heinrike, additional, and Seeger, Werner, additional

Published
2018
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212. Pulmonary hypertension due to lung diseases: Updated recommendations from the Cologne Consensus Conference 2018

Author

Olschewski, Horst, Behr, Juergen, Bremer, Hinrich, Claussen, Martin, Douschan, Philipp, Halank, Michael, Held, Matthias, Hoeper, Marius M., Holt, Stephan, Klose, Hans, Krueger, Stephan, Lange, Tobias J., Reichenberger, Frank, Skowasch, Dirk, Ulrich, Silvia, Wilkens, Heinrike, Seeger, Werner, Olschewski, Horst, Behr, Juergen, Bremer, Hinrich, Claussen, Martin, Douschan, Philipp, Halank, Michael, Held, Matthias, Hoeper, Marius M., Holt, Stephan, Klose, Hans, Krueger, Stephan, Lange, Tobias J., Reichenberger, Frank, Skowasch, Dirk, Ulrich, Silvia, Wilkens, Heinrike, and Seeger, Werner

Abstract

The 2015 European Guidelines on Pulmonary Hypertension did not only cover pulmonary arterial hypertension (PAH) but also some aspects of pulmonary hypertension (PH) associated with chronic lung disease. The European Guidelines point out that the drugs currently used to treat patients with PAH (prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors, sGC stimulators) have not been sufficiently investigated in other forms of PH. Therefore, the European Guidelines do not recommend the use of these drugs in patientswith chronic lung disease and PH. This recommendation, however, is not always in agreement with medical ethics as physicians sometimes feel inclined to treat other forms of PHwhichmay affect quality of life and survival of these patients in a similar manner. To this end, it is crucial to consider the severity of both PH and the underlying lung disease. In June 2016, a Consensus Conference organized by the PHworking groups of the German Society of Cardiology (DGK), the German Society of Respiratory Medicine (DGP) and the German Society of Paediatric Cardiology (DGPK) was held in Cologne, Germany, to discuss open and controversial issues surrounding the practical implementation of the European Guidelines. Several working groups were created, one of which was dedicated to the diagnosis and treatment of PH in patients with chronic lung disease. The 2018 updated recommendations of this working group are summarized in the present paper. (c) 2018 Published by Elsevier B.V.

Published
2018

213. Additional file 1: Table S1. of Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

Author

Kreuter, Michael, Swigris, Jeff, Pittrow, David, Geier, Silke, Klotsche, Jens, Prasse, Antje, Wirtz, Hubert, Koschel, Dirk, Andreas, Stefan, Claussen, Martin, Grohé, Christian, Wilkens, Henrike, Hagmeyer, Lars, Skowasch, Dirk, Meyer, Joachim, Kirschner, Joachim, Gläser, Sven, Herth, Felix, Welte, Tobias, Neurohr, Claus, Schwaiblmair, Martin, Held, Matthias, Bahmer, Thomas, Frankenberger, Marion, and Behr, Jürgen

Subjects
humanities
Abstract

Comparison of baseline characteristics of patients with and without available QoL data (total enrolled patients n = 737). (DOCX 15 kb)

Published
2017
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214. Endoscopic Lung Volume Reduction in COPD: The Impact of Coil Implantation on Patients' Physical Activity.

Author

Biener, Leonie, Skowasch, Dirk, Hollmann, Sophia, Schreiber, Tina, Nickenig, Georg, Fimmers, Rolf, and Pizarro, Carmen

Subjects
*PULMONARY emphysema treatment, *ACADEMIC medical centers, *ACCELEROMETERS, *ENDOSCOPY, *ENERGY metabolism, *LONGITUDINAL method, *OBSTRUCTIVE lung diseases, *PNEUMONECTOMY, *QUALITY of life, *PHYSICAL activity
Abstract

Endoscopic lung volume reduction (ELVR) is an emerging therapy option for the treatment of severe emphysema in COPD. To which extent patients profit from lung volume reduction via coils (LVRC) regarding morbidity, mortality, and quality of life is not clear yet. In this monocentric prospective cohort study, 13 COPD patients with severe emphysema (residual volume [RV] >225%) were enrolled at the University Hospital of Bonn. Activity measurements were assessed by a validated accelerometer wristband. By LVRC, RV could be reduced by 0.13 L to 5.54 ± 1.29 L. We could show a clinically relevant improvement in patients' physical activity after LVRC, measured as daily step count (497.7 ± 72.6 vs. 1,913.7 ± 182.7 steps/day, p = 0.03) and mean daily active energy expenditure (714.4 ± 73.6 vs. 2,321.3 ± 163.9 joules, p = 0.03). This improvement in physical activity is possibly associated with a positive effect on patients' morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2020
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215. Clinical features of sarcoidosis patients presenting with head and neck manifestations – a two-center retrospective study and proposal of a diagnostic algorithm for the otorhinolaryngologist.

Author

Send, Thorsten, Korsten, Peter, Bertlich3., Mattis, Braunwarth, Christoph, Bootz, Friedrich, Skowasch, Dirk, and Jakob, Mark

Subjects
SARCOIDOSIS diagnosis, THERAPEUTIC use of glucocorticoids, OTOLARYNGOLOGISTS, SARCOIDOSIS, ACADEMIC medical centers, AZATHIOPRINE, COMBINATION drug therapy, LUNGS, RETROSPECTIVE studies, LYMPH nodes, DIFFERENTIAL diagnosis, HEAD, METHOTREXATE, SYMPTOMS, DESCRIPTIVE statistics, NECK, LONGITUDINAL method
Abstract

Background and Aims: We aimed to investigate the clinical characteristics of patients presenting with sarcoidosis of the head and neck as the initial manifestation and to provide recommendations for the diagnostic work-up for the practicing otorhinolaryngologist. Material and Methods: We performed a retrospective cohort study at two university medical centers in Germany. Patients with a histopathologically confirmed diagnosis of sarcoidosis treated in the otorhinolaryngology departments were analyzed. Results: We identified 62 patients (2003–2016). In total, 85.4% (n = 53) of patients received the initial diagnosis of sarcoidosis during their ENT treatment. Sarcoidosis was detected in the lymph nodes in 42.3% (n = 30) of the patients; 57.7% had extra-lymphatic manifestations. Fifteen patients (24.2%) showed pulmonary involvement. 30.6% (n = 19) were treated with oral glucocorticoids (GC) alone, three patients with GC and methotrexate, one patient initially received a combination of GC and azathioprine, one patient rejected the recommended treatment. Conclusions: Sarcoidosis should be considered as a differential diagnosis in patients presenting with head and neck symptoms. The most frequent presenting symptoms were cervical lymphadenopathy and affection of the paranasal sinuses. Therefore, otorhinolaryngologists should be aware of sarcoidosis and help guide referral strategies as they may be the first physicians treating these patients. [ABSTRACT FROM AUTHOR]

Published
2020
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217. A double-blind, randomized, sham-controlled study of Targeted Lung Denervation in patients with moderate to severe COPD

Author

Slebos, Dirk-Jan, primary, Shah, Pallav, additional, Herth, Felix, additional, Pison, Christophe, additional, Schumann, Christian, additional, Kessler, Romain, additional, Bonta, Peter, additional, Gesierich, Wolfgang, additional, Hubner, Ralph-Harto, additional, Darwiche, Kaid, additional, Lamprecht, Bernd, additional, Perez, Thierry, additional, Skowasch, Dirk, additional, Deslee, Gaetan, additional, and Valipour, Arschang, additional

Published
2018
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219. Outcome differences between idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD) - data from the EXCITING registry

Author

Kreuter, Michael, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Witt, Sabine, additional, Leidl, Reiner, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Juergen, additional, Guenther, Andreas, additional, Kauschka, Dagmar, additional, Herth, Felix J.F., additional, and Markart, Philipp, additional

Published
2018
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220. Bronchial Thermoplasty Global Registry: One Year Results

Author

Torrego, Alfonso, primary, Herth, Felix, additional, Munoz, Ana M, additional, Puente, Luis, additional, Facciolongo, Nicola, additional, Bicknell, Stephen, additional, Novali, Mauro, additional, Gasparini, Stefano, additional, Bonifazi, Martina, additional, Dheda, Keertan, additional, Andreo, Felipe, additional, Votruba, Jiří, additional, Langton, David, additional, Flandes, Javier, additional, Fielding, David, additional, Bonta, P. I., additional, Skowasch, Dirk, additional, Ing, Alvin, additional, Schulz, Christian, additional, Darwiche, Kaid, additional, McMullen, Edmund, additional, Nolan, Fran, additional, and Niven, Robert, additional

Published
2018
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225. Carotid strain measurement in patients with pseudoxanthoma elasticum – Hint for a different pathomechanism?

Author

Passon, Sebastian Gorgonius, primary, Küllmar, Viviane, additional, Blatzheim, Anna Katharina, additional, Pausewang, Kristin Solveig, additional, Stumpf, Max Jonathan, additional, Hendig, Doris, additional, Gliem, Martin, additional, Pingel, Simon, additional, Schueler, Robert, additional, Skowasch, Dirk, additional, Schahab, Najib, additional, Nickenig, Georg, additional, and Schaefer, Christian Alexander, additional

Published
2018
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227. High prevalence of COPD in atherosclerosis patients

Author

Tuleta,Izabela, Farrag,Tarik, Busse,Laura, Pizarro,Carmen, Schaefer,Christian, Pingel,Simon, Nickenig,Georg, Skowasch,Dirk, Schahab,Nadjib, Tuleta,Izabela, Farrag,Tarik, Busse,Laura, Pizarro,Carmen, Schaefer,Christian, Pingel,Simon, Nickenig,Georg, Skowasch,Dirk, and Schahab,Nadjib

Abstract

Izabela Tuleta, Tarik Farrag, Laura Busse, Carmen Pizarro, Christian Schaefer, Simon Pingel, Georg Nickenig, Dirk Skowasch, Nadjib Schahab Department of Internal Medicine II – Cardiology, Pulmonology and Angiology, University of Bonn, Bonn, Germany Abstract: Atherosclerosis and COPD are both systemic inflammatory diseases that may influence each other. The aim of the present study was to determine the prevalence of COPD in patients with cerebral and/or peripheral artery disease and to assess factors associated with the presence of COPD. Following the diagnosis of cerebral and/or peripheral artery disease by means of duplex sonography, 166 consecutive patients underwent body plethysmography with capillary blood gas analysis. Thereafter, blood tests with determination of different parameters such as lipid profile, inflammatory and coagulation markers were conducted in remaining 136 patients who fulfilled inclusion criteria of the study. Thirty-six out of 136 patients suffered from COPD, mostly in early stages of the disease. Residual volume indicating emphysema was increased (162.9%±55.9% vs 124.5%±37.0%, p<0.05) and diffusion capacity was decreased (55.1%±19.5% vs 75.3%±18.6%, p<0.05) in COPD patients vs non-COPD group. In capillary blood gas analysis, COPD patients had lower partial pressure of oxygen (70.9±11.5 vs 75.2±11.0 mmHg, p<0.05) and higher partial pressure of carbon dioxide (36.8±7.5 vs 34.4±4.4 mmHg, p<0.05) compared with non-COPD individuals. Presence of COPD was associated with predominance of diabetes mellitus, interleukin-8-related systemic neutrophilic inflammation and anemia. In conclusion, COPD is highly prevalent in patients with atherosclerotic artery disease. Keywords: cerebral artery disease, peripheral artery disease, lung function, capillary blood gas, diabetes mellitus, inflammation, interleukin-8, anemia

Published
2017

228. Asthma is associated with atherosclerotic artery changes

Author

Tuleta, Izabela, primary, Skowasch, Dirk, additional, Aurich, Florian, additional, Eckstein, Nicolas, additional, Schueler, Robert, additional, Pizarro, Carmen, additional, Schahab, Nadjib, additional, Nickenig, Georg, additional, Schaefer, Christian, additional, and Pingel, Simon, additional

Published
2017
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229. High prevalence of COPD in atherosclerosis patients

Author

Tuleta, Izabela, primary, Farrag, Tarik, additional, Busse, Laura, additional, Pizarro, Carmen, additional, Schaefer, Christian, additional, Pingel, Simon, additional, Nickenig, Georg, additional, Skowasch, Dirk, additional, and Schahab, Nadjib, additional

Published
2017
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233. Gender associated Differences in Patients with IPF based on the Analysis of the INSIGHTS-IPF Registry Data

Author

Prasse, Antje, primary, Kreuter, Michael, additional, Klotsche, Jens, additional, Koschel, Dirk, additional, Frankenberger, Marion, additional, Neurohr, Claus, additional, Schwaiblmair, Martin, additional, Skowasch, Dirk, additional, Claussen, Martin, additional, Gläser, Sven, additional, Wilkens, Henrike, additional, Grohe, Christian, additional, Hagmeier, Lars, additional, Kirschner, Joachim, additional, Andreas, Stefan, additional, Wirtz, Hubert, additional, Pittrow, David, additional, Behr, Jürgen, additional, and Geier, Silke, additional

Published
2017
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234. Exacerbations, hospitalisations and mortality in patients with idiopathic pulmonary fibrosis in clinical practice: INSIGHTS-IPF registry

Author

Behr, Juergen, primary, Pittrow, David, additional, Prasse, Antje, additional, Wirtz, Hubert, additional, Koschel, Dirk, additional, Andreas, Stefan, additional, Claussen, Martin, additional, Grohé, Christian, additional, Wilkens, Heinrike, additional, Hagmeier, Lars, additional, Skowasch, Dirk, additional, Meyer, F. Joachim, additional, Kirschner, Joachim, additional, Gläser, Sven, additional, Herth, Felix J.F., additional, Welte, Tobias, additional, Neurohr, Claus, additional, Schwaiblmair, Martin, additional, Held, Matthias, additional, Bahmer, Thomas, additional, Geier, Silke, additional, Klotsche, Jens, additional, Frankenberger, Marion, additional, and Kreuter, Michael, additional

Published
2017
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237. Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

Author

Kreuter, Michael, primary, Swigris, Jeff, additional, Pittrow, David, additional, Geier, Silke, additional, Klotsche, Jens, additional, Prasse, Antje, additional, Wirtz, Hubert, additional, Koschel, Dirk, additional, Andreas, Stefan, additional, Claussen, Martin, additional, Grohé, Christian, additional, Wilkens, Henrike, additional, Hagmeyer, Lars, additional, Skowasch, Dirk, additional, Meyer, Joachim F, additional, Kirschner, Joachim, additional, Gläser, Sven, additional, Herth, Felix J. F., additional, Welte, Tobias, additional, Neurohr, Claus, additional, Schwaiblmair, Martin, additional, Held, Matthias, additional, Bahmer, Thomas, additional, Frankenberger, Marion, additional, and Behr, Jürgen, additional

Published
2017
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238. Modulation of carotid strain by statin therapy in atherosclerosis patients

Author

Schaefer, Christian Alexander, primary, Blatzheim, Anna Katharina, additional, Passon, Sebastian Gorgonius, additional, Pausewang, Kristin Solveig, additional, Schahab, Nadjib, additional, Nickenig, Georg, additional, Skowasch, Dirk, additional, Schueler, Robert, additional, Hammerstingl, Christoph, additional, and Pingel, Simon, additional

Published
2017
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240. Increased vascular occlusion in patients with pseudoxanthoma elasticum

Author

Pingel, Simon, primary, Pausewang, Kristin Solveig, additional, Passon, Sebastian Gorgonius, additional, Blatzheim, Anna Katharina, additional, Gliem, Martin, additional, Issa, Peter Charbel, additional, Hendig, Doris, additional, Horlbeck, Fritz, additional, Tuleta, Izabela, additional, Nickenig, Georg, additional, Schahab, Nadjib, additional, Skowasch, Dirk, additional, and Schaefer, Christian Alexander, additional

Published
2017
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242. Left Ventricular Myocardial Fibrosis, Atrophy, and Impaired Contractility in Patients With Pulmonary Arterial Hypertension and a Preserved Left Ventricular Function

Author

Homsi, Rami, primary, Luetkens, Julian A., additional, Skowasch, Dirk, additional, Pizarro, Carmen, additional, Sprinkart, Alois M., additional, Gieseke, Juergen, additional, Meyer zur Heide gen. Meyer-Arend, Julia, additional, Schild, Hans H., additional, and Naehle, Claas P., additional

Published
2017
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244. Speckle tracking echocardiography in chronic obstructive pulmonary disease and overlapping obstructive sleep apnea

Author

Pizarro,Carmen, van Essen,Fabian, Linnhoff,Fabian, Schueler,Robert, Hammerstingl,Christoph, Nickenig,Georg, Skowasch,Dirk, Weber,Marcel, Pizarro,Carmen, van Essen,Fabian, Linnhoff,Fabian, Schueler,Robert, Hammerstingl,Christoph, Nickenig,Georg, Skowasch,Dirk, and Weber,Marcel

Abstract

Carmen Pizarro,* Fabian van Essen,* Fabian Linnhoff, Robert Schueler, Christoph Hammerstingl, Georg Nickenig, Dirk Skowasch, Marcel Weber Department of Internal Medicine II, Cardiology, Pneumology and Angiology, University Hospital Bonn, Bonn, Germany *These authors contributed equally to this work Background: COPD and congestive heart failure represent two disease entities of growing global burden that share common etiological features. Therefore, we aimed to identify the degree of left ventricular (LV) dysfunction in COPD as a function of COPD severity stages and concurrently placed particular emphasis on the presence of overlapping obstructive sleep apnea (OSA).Methods: A total of 85 COPD outpatients (64.1±10.4 years, 54.1% males) and 20 controls, matched for age, sex, and smoking habits, underwent speckle tracking echocardiography for LV longitudinal strain imaging. Complementary 12-lead electrocardiography, laboratory testing, and overnight screening for sleep-disordered breathing using the SOMNOcheck micro® device were performed.Results: Contrary to conventional echocardiographic parameters, speckle tracking echocardiography revealed significant impairment in global LV strain among COPD patients compared to control smokers (-13.3%±5.4% vs -17.1%±1.8%, P=0.04). On a regional level, the apical septal LV strain was reduced in COPD (P=0.003) and associated with the degree of COPD severity (P=0.02). With regard to electrocardiographic findings, COPD patients exhibited a significantly higher mean heart rate than controls (71.4±13.0 beats per minute vs 60.3±7.7 beats per minute, P=0.001) that additionally increased over Global Initiative for Chronic Obstructive Lung Disease stages (P=0.01). Albeit not statistically significant, COPD led to elevated N-terminal pro-brain natriuretic peptide levels (453.2±909.0 pg/mL vs 96.8±70.0 pg/mL, P=0.08). As to somnological testing, the portion o

Published
2016

245. Invasive coronary angiography in patients with acute exacerbated COPD and elevated plasma troponin

Author

Pizarro,Carmen, Herweg-Steffens,Neele, Buchenroth,Martin, Schulte,Wolfgang, Schaefer,Christian, Hammerstingl,Christoph, Werner,Nikos, Nickenig,Georg, Skowasch,Dirk, Pizarro,Carmen, Herweg-Steffens,Neele, Buchenroth,Martin, Schulte,Wolfgang, Schaefer,Christian, Hammerstingl,Christoph, Werner,Nikos, Nickenig,Georg, and Skowasch,Dirk

Abstract

Carmen Pizarro,1,* Neele Herweg-Steffens,1,* Martin Buchenroth,2 Wolfgang Schulte,3 Christian Schaefer,1 Christoph Hammerstingl,1 Nikos Werner,1 Georg Nickenig,1 Dirk Skowasch1 1Department of Internal Medicine II – Cardiology, Pneumology and Angiology, University Hospital Bonn, Germany; 2Department of Pneumology, Johanniter Hospital Bonn, Germany; 3Department of Pneumology, Malteser Hospital Bonn/Rhein-Sieg, Germany *These authors contributed equally to this work Background: In acute exacerbation of COPD, increased plasma levels of cardiac troponin are frequent and associated with increased mortality. Thus, we aimed at prospectively determining the diagnostic value of coronary angiography in patients with exacerbated COPD and concomitantly elevated cardiac troponin. Patients and methods: A total of 88 patients (mean age 72.9±9.2 years, 56.8% male) hospitalized for acute exacerbation of COPD with elevated plasma troponin were included. All patients underwent coronary angiography within 72 hours after hospitalization. Complementary 12-lead electrocardiogram, transthoracic echocardiography, pulmonary function, and angiological testing were performed.Results: Coronary angiography objectified the presence of ischemic heart disease (IHD) in 59 patients (67.0%), of whom 34 patients (38.6% of total study population) underwent percutaneous coronary intervention. Among these 34 intervened patients, the vast majority (n=26, 76.5%) had no previously known IHD, whereas only eight out of 34 patients (23.5%) presented an IHD history. Patients requiring coronary intervention showed significantly reduced left ventricular ejection fraction (45.8%±13.1% vs 55.1%±13.3%, P=0.01) and a significantly more frequent electrocardiographic ST-segment depression (20.6% vs 7.4%, P=0.01). Neither additional laboratory parameters for inflammation and myocardial injury nor lung functional measurements differed significantly between the gr

Published
2016

248. Somatostatin receptor based PET/CT in patients with the suspicion of cardiac sarcoidosis: an initial comparison to cardiac MRI

Author

Lapa, Constantin, primary, Reiter, Theresa, additional, Kircher, Malte, additional, Schirbel, Andreas, additional, Werner, Rudolf A., additional, Pelzer, Theo, additional, Pizarro, Carmen, additional, Skowasch, Dirk, additional, Thomas, Lena, additional, Schlesinger-Irsch, Ulrike, additional, Thomas, Daniel, additional, Bundschuh, Ralph A., additional, Bauer, Wolfgang R., additional, and Gärtner, Florian C., additional

Published
2016
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249. Lower extremity and carotid artery disease in COPD

Author

Pizarro, Carmen, primary, Linnhoff, Fabian, additional, van Essen, Fabian, additional, Pingel, Simon, additional, Schaefer, Christian Alexander, additional, Schahab, Nadjib, additional, Fimmers, Rolf, additional, Nickenig, Georg, additional, and Skowasch, Dirk, additional

Published
2016
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250. Pseudoxanthoma Elasticum – Also a Lung Disease? The Respiratory Affection of Patients with Pseudoxanthoma Elasticum

Author

Pingel, Simon, primary, Passon, Sebastian Gorgonius, additional, Pausewang, Kristin Solveig, additional, Blatzheim, Anna Katharina, additional, Pizarro, Carmen, additional, Tuleta, Izabela, additional, Gliem, Martin, additional, Charbel Issa, Peter, additional, Schahab, Nadjib, additional, Nickenig, Georg, additional, Skowasch, Dirk, additional, and Schaefer, Christian Alexander, additional

Published
2016
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