Search

Das nervöse und psychosoziale System des Menschen ist nicht statisch, sondern unterliegt kontinuierlich den Einflüssen der Entwicklung. Dieser Entwicklungsprozess ist aber kein gleichmäßiges Dahingleiten, sondern jede Lebensphase unterscheidet sich von der vorhergehenden und der nachfolgenden. Je nach Lebensphase und dem erreichten Entwicklungsalter gestalten sich die Lebensäußerungen, die Strategien zur Lebensbewältigung und nicht zuletzt auch die Psychopathologie des Individuums. Im ersten Abschnitt wird die Lebensthematik in den einzelnen Entwicklungsphasen mit ihren Risiken, Chancen und Krisen dargestellt. Im zweiten Abschnitt wird gezeigt, wie sich die Symptome von bestimmten Erkrankungen manifestieren und wie sie sich in den einzelnen Lebensphasen unterscheiden. Die psychiatrischen Krankheitsbilder und Reaktionsweisen sowie ihre entwicklungsspezifischen Ausprägungen werden zusammenfassend hervorgehoben. Im abschließenden Abschnitt werden die psychiatrischen Behandlungsverfahren dargestellt und gezeigt, dass das Entwicklungsalter ganz wesentlich die therapeutischen Vorgangsweisen, sowohl Medikamente als auch Psychotherapie betreffend, prägt.

Das Buch umfaßt die ganze Bandbreite der neurobiologischen Ansätze bei verschiedenen psychiatrischen Erkrankungen, sowohl hinsichtlich der Ätiopathogenese als auch der Therapie. In Form von Übersichtsarbeiten und Originalpublikationen von Ergebnissen einzelner Studien wird ein sehr aktuelles und sehr weit gefächertes Spektrum der biologisch-psychiatrischen Forschung geliefert. Neben einer Vielzahl anderer Themen stehen dabei dementielle Erkrankungen, angesichts der medizinischen und gesundheitspolitischen Bedeutung und der derzeitigen Intensität von Forschungsaktivitäten, ganz besonders im Mittelpunkt.

Dieses Buch stellt in kurzer und übersichtlicher Form Leitlinien zur Diagnostik und Therapie von psychiatrischen Erkrankungen im Alter dar. Aufbauend auf den langjährigen Erfahrunges des Autors mit dieser Patientengruppe, die aufgrund der demographischen Entwicklung stark zunimmt, werden Leitlinien zu medikamentösen und psychotherapeutischen Behandlungsmöglichkeiten dargestellt. Checklisten und Flußdiagramme erleichtern die diagnostischen und therapeutischen Entscheidungen beim Umgang mit diesen Patienten.

Hard Ball Systems and the Lorentz Gas are fundamental models arising in the theory of Hamiltonian dynamical systems. Moreover, in these models, some key laws of statistical physics can also be tested or even established by mathematically rigorous tools. The mathematical methods are most beautiful but sometimes quite involved. This collection of surveys written by leading researchers of the fields - mathematicians, physicists or mathematical physicists - treat both mathematically rigourous results, and evolving physical theories where the methods are analytic or computational. Some basic topics: hyperbolicity and ergodicity, correlation decay, Lyapunov exponents, Kolmogorov-Sinai entropy, entropy production, irreversibility. This collection is a unique introduction into the subject for graduate students, postdocs or researchers - in both mathematics and physics - who want to start working in the field.

Die Neuropathologie hat sich dank ihrer engen Anlehnung an klinische Fragestellungen, ihrer klaren Diktion und der reichhaltigen Bebilderung rasch einen breiten Leserkreis unter neurologisch interessierten Ärzten und Pathologen erworben. Nach wie vor ist die Morphologie der Krankheiten des Nervensystems und der Skelettmuskulatur die Voraussetzung für das Verständnis der Pathogenese und die Basis der neurologischen, neurochirurgischen und -radiologischen Diagnostik; von gleichem Interesse aber auch für Psychiater und Neuropädiater in Klinik und Praxis. Die rasche Entwicklung der Molekulargenetik mit ihrer Konsequenz neuer Klassifikationen, differenzierter Diagnostik und Prognoseeinschätzung machte eine 3. Auflage notwendig. Einige neue Autoren mit speziellen Erfahrungen, z.B. auf dem Gebiet der Prionenerkrankungen, bürgen für die Aktualität der Darstellungen.

Zu den häufigsten Alterserkrankungen zählen heute die Parkinson'sche Erkrankung sowie Demenzen. Eine Reihe neuer Erkenntnisse der Grundlagenforschung sowie die Entwicklung neuer Neuro-Psychopharmaka für die genannten Indikationen machten eine Neubearbeitung des Bandes erforderlich. In den vergangenen zwei Jahren wurden unter den Parkinson-Mitteln neue Dopamin-Agonisten, COMT-Hemmer sowie NMDA-Antagonisten zugelassen. Zur Behandlung der Alzheimer-Demenz wurden Antidementiva (Cholinesterosehemmer) entwickelt, weitere medikamentöse Therapieeinsätze befinden sich im Stadium der klinischen Prüfung und werden ebenfalls dargestellt. In gewohnter Form illustrieren zahlreiche Tabellen und Abbildungen die einzelnen Parkinsonmittel und Antidementiva (Nootropika). In Übersichtstabellen finden Sie Einzelpräparate – farblich abgesetzt mit wichtigen praktisch-klinischen Angaben – zur raschen Information. Ergänzend widmen sich mehrere Exkurse speziellen Fragen wie z. B. der Therapie von Dystonien oder der Chorea Huntington. Mit Beiträgen von A. Andrich, E. Auff, H. Baas, G. Becker, T. Becker, S. Bleich, H. M. Brecht, W. Danielczyk, G. Deuschl, T. Dierks, O. Dietmaier, A. Enz, E. Fertl, P.-A. Fischer, L. Frölich, M. Gerlach, H. Hampel, U. Hegerl, A. Heidrich, H. Herrschaft, C. Hock, S. Hoyer, K. Jellinger, K. Jorga, W. Juretzek, S. Kanowski, J. Kornhuber, P. H. Kraus, W. Kuhn, B. Lack, K. W. Lange, G. Laux, K. Maurer, H.-J. Möller, Th. Müller, W. E. Müller, F. Müller-Spahn, M. Naumann, N. Nedopil, W. Oertel, W. Poewe, W. Pöldinger, H. Przuntek, H. Reichmann, W. Retz, P. Riederer, M. Rösler, E. Savaskan, E. Schneider, M. Streifler, O. Tucha, G. Ulm, H.-P. Volz, H. Wachtel, G. K. Wenning, J. Wiltfang, G. Zürcher.

Das Buch beschäftigt sich mit aktuellen Problemen der Neuroleptika-Behandlung. Dabei wird insbesondere auf den Stellenwert der Thioxanthene eingegangen.

Circadian Rhythms and the Human covers the basic principles behind the human circadian rhythms. This book is composed of 12 chapters that discuss the detection, analysis, and definition of rhythms, specifically exogenous and endogenous rhythms. This book also demonstrates the mechanism of metabolic and gastrointestinal rhythms. The opening chapters deal with the rhythms in living organism; establishing the endogeneity of rhythms; definition of nychthemeral rhythm; methods of measuring the frequency of rhythms; exogenous effects upon the temperature rhythm; interaction between exogenous and endogenous influences; and possible origins of renal rhythmicity. The succeeding chapters consider the effect of exercise at different times of day and the concept of sleep-wakefulness rhythm. The discussion then shifts to the effects of repeated time-zone transitions and the effects of time on drug administration. The closing chapters are devoted to the assessment of work performance during shift work. The book can provide useful information to doctors, students, researchers, and the general reader.

Highly Commended, BMA Medical Book Awards 2014This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatme

As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer's disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer's disease.

Volume 5 of the series'Advances in Research on Neurodegeneration'is concerned with themes which are currently the focus of intensive research, and in which advances in our understanding of the pathological mechanisms un­ derlying neurodegenerative diseases are expected in the near future. The first section contains five reviews devoted to the various neuroimaging technolo­ gies. The discussion is concerned with the question of whether neuroimaging techniques make it possible to follow the process of degeneration as it occurs, and which methods offer the required sensitivity and quantifiability for this purpose. However, the question needs to be examined of whether, given the physical and chemical limitations of these techniques, even under optimal conditions, anatomical resolution can be improved to the extent that neuro­ degenerative diseases can be diagnosed earlier than currently possible and a confident diagnosis made. The possibilities of using neuroimaging techniques to provide information regarding the effects of neuroprotective or neuroregen­ erative therapeutic strategies, and for correlating the results of neuropsycho­ logical research with imaging data are also discussed. The second section is concerned with the significance of endogenous or exogenous neurotoxins as triggers for neurodegenerative processes that may lead to Parkinsonism. Vulnerability factors, which include such factors as nerve ending sensitivity, the synergistic effects of drugs and the various mechanisms underlying different toxins are discussed.

In diesem Buch sind die Beiträge zum 28. Hämophilie-Symposion 1997 zusammengetragen. Schwerpunktthemen sind Virusinfektion, Synovitis-Pathogenese und Behandlung, Thrombophilie: Prothrombinmutation und Pädiatrische Hämostaseologie. Zahlreiche freie Redebeiträge und Poster zur Hämophilie und angrenzenden Gebieten runden diese Zusammenstellung ab.

Das'Handbuch der klinisch-psychologischen Behandlung'bietet eine konkrete Umsetzung von wissenschaftlichen Theorien und Modellen in die alltägliche Praxis. Internationale Experten behandeln nach einem einheitlichen Aufbauschema für jedes Störungsbild folgende Aspekte: • Beschreibung des Störungsbildes nach ICD-10 mit Querverweisen zu ICD-9 und zu DSM-IV • klinisch-psychologische Diagnostik • spezifische Interventionstechniken • Indikation/Kontraindikation • Integration mit medizinischen oder anderen Verfahren • empirische Studien • Ausschnitt aus einem Fallbeispiel • Zusammenfassung • Fachliteratur und Literatur für Patienten Im Anhang werden für die wichtigsten Störungsbilder nach ICD-10 und DSM-VI die verschiedenen psychologischen Interventionsformen und Behandlungstechniken systematisch zusammengestellt.

Die Vielfalt der hier vorgestellten Beiträge spiegelt das unermüdliche Bestreben aller in die Therapie von Parkinsonpatienten Involvierten wider, Lebensqualität und Wohlbefinden von chronisch Kranken und deren Angehörigen zu verbessern und diese komplexe Erkrankung auch vor dem Hintergrund von Begleiterkrankungen zu betrachten. Einerseits wird die Bedeutung vegetativer und sensorischer Störungen diskutiert, andererseits wird der Einfluss von Begleiterkrankungen und ausgeprägten Begleitsyndromen auf Therapie und Verlauf der Erkrankung vor dem Hintergrund persönlicher Erfahrungen vorgestellt. Diese Zusammenstellung bietet Erkenntnisse über mögliche Interaktionen, die im Rahmen der medikamentösen Kombinationstherapie zu beachten sind, sowie eine Bewertung der gängigen intensivmedizinischen Vorgehensweisen und der neu entwickelten Therapieverfahren wie der Tiefenhirnstimulation und eine Bewertung von Langzeitaspekten.

This volume represents the collected papers presented at the Third Triennial Symposium of the International Basal Ganglia society (IBAGS) held at Capo Boi, Italy, June 10-13, 1989. About 300 members of the society and participants attended the symposium which was held in a delightful environment conducive to the formal and informal exchange of scientific thought. The interdisciplinary nature of the symposium was unique in its coverage of the neurosciences from molecular biology to clinical and behavioural studies. The 80 papers collected here reflect the wide spectrum and the depth of studies on virtually all aspects of the basal ganglia. Unfortunately, this book does not capture the cordial and congenial atmosphere which has characterized this, and all prior symposia of the Society. Any cooperative endeavour of this kind requires a tremendous effort and dedication, usually by a small number of individuals. The Society is especially pleased to acknowledge the support and encouragement of the'Italian Ministry of university and Scientific Research'and the'Italian National. Research Council'. In addition the society received financial support from numerous Foundations and corporations, which are listed separately under acknowledgements. Finally the Editors are pleased that Plenum Press, which has published the two previous symposia, has accepted this program for publication. It is our hope that vast scientific efforts reflected in these pages will be widely disseminated and further encourage every kind of research related to the basal ganglia.

Selected papers from the prestigious Stonwin Medical Conference, which each summer invites a small group of neurosurgical investigation. This volume presents recent advances in research and practice of surgery of the severed spinal cord. Future volumes will treat similarly focused, cutting-edge topics. In terms of editorial strategy, this series will afford Springer entree to a select groups of neurosurgeons.

This wonderful, profusely illustrated book provides a concise and thoughtful review of all the important diseases of the child's brain. The lesions are well organized into logical categories that help the reader to remember the information conveyed. The important features of each entity are discussed thoroughly. Data from the literature are documented by selected references and are clearly distinguished from the authors'personal experience. The gross pathology of each disease is illustrated by well selected, high quality CT scans and supporting neuroradiological studies. Each caption begins with the relevant clinical data, so the reader understands the clinical context in which the study was obtained. The caption then describes the specific CT features of the case, so the reader learns to interpret the images correctly to arrive at the final diagnosis. By this technique, the authors provide the reader with a large experience in all aspects of pediatric cranial CT and teach him to distinguish properly among the diverse disease states. The authors must be congratulated for their excellence and their me­ ticulous attention to detail. They have written an important book that brings together the fields of pediatric neurology and pediatric cranial CT, enhancing both. This volume is a necessary addition to the personal and professional libraries of all physicians who care for children: pediatri­ cians, neurologists, neurosurgeons and radiologists. I feel I am a better physician for having read this text.

This book is being published as we mark the end of the first 50 years of the modern antidepressant era. This era began with the chance discovery that tri- clic antidepressants and monoamine oxidase inhibitors had antidepressant p- perties. That discovery had three consequences. First, it brought simple and effective treatment to patients suffering from major depressive illnesses. Second, these discoveries, together with the discovery of lithium and chlorpromazine, began the remedicalization of psychiatry by making it clear that the treatment of many of the major psychiatric illnesses can be approached in the same way as other medical conditions. However, the most far-reaching effect was to provide the first clue as to what mechanisms might underlie antidepressant efficacy, a development that has led to an explosion in the number of available an- depressants and to their widespread use. The goal of this book is to provide a thorough review of the current status of antidepressants—how we arrived at this point in their evolution and where we are going in both the near and the long term. The book employs both a scientific and historical approach to accomplish these goals. The book is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that the book provides a comprehensive and logical approach to this important group of medications. The importance of the book is a function of its topic.

This book presents current research in the study of neurologic disorders. Topics discussed include oxidative stress-mediated neurodegeneration; mechanisms of the motoneuron stress response and its relevance in neurodegeneration; genetics and molecular biology of Alzheimer's disease and frontotemporal lobar degeneration; molecular imaging and Parkinson's disease; mitochondrion selective antioxidants as drug treatments for Alzheimer's disease; the role of vitamins in vascular dementia and biofluid protein biomarkers for the diagnosis of vascular dementia.

With contributions by numerous experts

Interest in Ginkgo biloba has grown dramatically in the last 10 years, along with a corresponding increase in research on this unique plant. This book provides an overview and recent findings concerning cell biology, biochemistry, development, morphology, phylogeny, paleobotany, as well as possible applications in chemistry and medicine. It also covers environmental aspects and the relationship between G. biloba and humans. The book will be of wide interest to botanists, horticulturists and scientists working on this attractive and useful plant. This book commemorates the hundredth anniversary of the discovery of Ginkgo sperm by Sakugoro Hirase and will both stimulate further study, and contribute to the development of new fields in Ginkgo research.

This volume contains the proceedings of the 14th Colloque Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique devoted to Alzheimer's Disease and dedicated to the epidemiological study of this dementia, a very important issue because the incidence and prevalence of Alzheimer's Disease rise exponentially with age. Epidemiological findings not only confirm dementia as a major challenge for the coming years but also contribute defining risk factors, predicting and may be preventing this disease.

Now in its Fifth Edition, Clinical Neuropsychology reviews the major neurobehavioral disorders associated with brain dysfunction and injury. Like previous editions of this book, the Fifth Edition focuses on the clinical presentation of the major neurobehavioral syndromes, including symptoms, signs, and methods of assessment that are useful for diagnosis, and also their underlying anatomy, physiology, and pathology. The major behavioral disorders that are covered include aphasia, agraphia, alexia, amnesia, apraxia, neglect, executive disorders and dementia. The text also discusses advances in assessment, diagnosis and treatment of these disorders. The authors attempt to explain the cognitive mechanisms that can account for specific symptoms and signs, and to provide new information about treatment and management. The authors have drawn from a wealth of new information and research that has emerged since the Fourth Edition was published in 2003. The editors have added a chapter on creativity to the Fifth Edition, since there has been increased interest in creativity, and brain disorders can either enhance or impair creativity. This text will be of value to clinicians, investigators, and students from a variety of disciplines, including neurology, psychology, cognitive neuroscience, psychiatry, and speech pathology.

As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.

Vascular dementia is the second most common form of dementia after Alzheimer's disease in older adults. The term refers to a group of syndromes caused by different mechanisms all resulting in vascular lesions in the brain. Early detection and accurate diagnosis are important, as vascular dementia is at least partially preventable. Risk factors for vascular dementia include hypertension, smoking, hypercholesterolemia, diabetes mellitus, and cardiovascular and cerebrovascular disease. This book presents current research from across the globe in the study of vascular dementia, including GRK2 overexpression in the context of early Alzheimer disease pathogenesis; vitamin deficiencies and vascular dementia; biofluid markers as potential markers for vascular dementia; and the epidemiology of vascular dementia.

Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.

The renowned Principles and Practice of Geriatric Psychiatry, now in its third edition, addresses the social and biological concepts of geriatric mental health from an international perspective. Featuring contributions by distinguished authors from around the world, the book offers a distinctive angle on issues in this continually developing discipline. Principles and Practice of Geriatric Psychiatry provides a comprehensive review of: geriatric psychiatry spanning both psychiatric and non-psychiatric disorders scientific advances in service development specific clinical dilemmas New chapters on: genetics of aging somatoform disorders epidemiology of substance abuse somatoform disorders care of the dying patient Continuing the practice of earlier editions, the major sections of the book address aging, diagnosis and assessment and clinical conditions, incorporating an engaging discussion on substance abuse and schizophrenic disorders. Shorter sections include the presentation of mental illness in elderly people from different cultures—one of the most popular sections in previous editions. Learning and behavioural studies, as well as models of geriatric psychiatry practice, are covered extensively. This book provides a detailed overview of the entire range of mental illness in old age, presented within an accessible format. Principles and Practice of Geriatric Psychiatry is an essential read for psychiatrists, geriatricians, neurologists and psychologists. It is of particular use for instructors of general psychiatry programs and their residents.

S3 Praxisleitlinien in Psychiatrie und Psychotherapie - Nationale VersorgungsLeitlinie Unipolare Depression. Es gehört zu den Aufgaben der medizinisch-wissenschaftlichen Fachgesellschaften, Leitlinien zu entwickeln und ihren Praxistransfer zu gewährleisten. Leitlinien beruhen auf empirischer Evidenz und Expertenkonsens und sollen dem praktisch Tätigen dazu dienen, Diagnostik und Therapie nach den Regeln der Kunst zu gestalten. Auf der einen Seite sollen sie den Arzt nicht binden, drücken aber doch eine gewissen Verbindlichkeit aus. Leitlinien sind immer dem jeweiligen Stand der Wissenschaft angepasst und geben einen evidenzbasierten Handlungsrahmen vor; dies ist gerade für jüngere Ärzte und Therapeuten eine unschätzbare Hilfe in der täglichen Arbeit.

The second edition of Management of Dementia combines a balanced review of the latest knowledge and research in this area with practical guidance based on the authors'considerable personal experience of dementia care. It is directed at professionals working in the area who want to practice evidence-based medicine without losing sight of the p

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.

This is a book of psychiatry at its most practical level. It aims to answer the sorts of questions psychiatrists ask on a daily basis. What treatments are available for the condition that I think this patient has? What is the relative value of each of these treatments? Are there any other treatments that I should be considering if a first approach has failed? Is there any value in combinations of treatment? And, can I be sure that the evidence and recommendations I read are free from bias? The content is organised into three sections covering disease classification, the major treatment modalities and the application of these treatments to the wide range of psychiatric diagnoses. All professionals in mental health want to give the best treatments for their patients. This book provides clinicians with the knowledge and guidance to achieve this aim.

Treating stroke requires attention not only to patients'physical needs, but to their psychiatric needs as well. Unfortunately, there has been a considerable lack of literature that tackles this important facet of recovery. The Psychiatry of Stroke fills this void through a comprehensive examination that explores the mental and physical issues faced by stroke patients and offers up-to-date treatment options. Based on extensive clinical experience, the text offers practical advice for improving the treatment of stroke by increasing the attention paid to its mental aspects. Detailed and definitive, this unique text demonstrates how mental impairment sets limits to stroke treatment and rehabilitation and shows how to evaluate and treat these impairments. Accessible to a wide range of readers, this new edition presents detailed reviews of classical papers as well as more basic outlines that provide a general overview. Regardless of familiarity, readers will find comprehensive and authoritative guidance for improving treatment. Some of the topics covered include: background and causation risk factors and diagnosis of stroke localization of mental functions neuropsychopharmachology psychiatric syndromes apathy and failure to rehabilitate depression, anxiety, and dementia sex anger and violence outcome and effects the process of recovery family treatment team legal issues, money, and ethics and much more! The Psychiatry of Stroke also includes a wealth of informative tables and diagrams as well as a full glossary of terms. Extensively referenced, this important text also provides useful appendices that look at resources for caregivers and the anatomy and historical significance of stroke. Physicians and mental health professionals who treat stroke patients; staff of stroke units and rehabilitation hospitals and centers; fellows in geriatric psychiatry, geriatrics, and stroke programs; gerontology students and educators; and families of the victims of stroke or vascular dementia will find this book an invaluable day-to-day resource.

This blue-ribbon guide has long prevailed as one of the leading resources on Parkinson's Disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advan

This comprehensive reference addresses all aspects of fetal and neonatal pathology, including complicated pregnancies, multiple pregnancies, abortion, placental pathology, and disorders affecting the full-term neonate. A consistent organization allows for quick access to specific guidance, and nearly 2,500 illustrations - 2,350 in full color - depict conditions and abnormalities as they present in practice, facilitating diagnosis. An Image Bank on CD-ROM - new to this edition - features all of the illustrations from the 2-volume set, downloadable for presentations. - Offers comprehensive coverage of all common and rare embryonic, fetal, and infant disorders in one source. - Correlates clinical, pathologic, and genetic findings for each systemic disease. - Emphasizes the genetic and molecular basis of birth defects.Features nearly 2,500 illustrations - 2,350 in full color - which depict each abnormality or condition as they present in practice. - Presents practical information on autopsy techniques and protocols.Provides the latest guidance on molecular pathology, immunohistochemistry, DNA technology, and more. - Offers an expanded discussion of developmental biology related to the pathogenesis of birth defects. - Features user-friendly summary tables and diagnostic flow charts, making information quick and easy to find. - Includes a CD-ROM featuring all of the illustrations from the 2-volume set.

In two freestanding but linked volumes, Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. This volume, Medical Neurorehabilitation, can stand alone as a clinical handbook for neurorehabilitation. It covers the practical applications of the basic science principles presented in volume 1, provides authoritative guidelines on the management of disabling symptoms, and describes comprehensive rehabilitation approaches for the major categories of disabling neurological disorders. Emphasizing the integration of basic and clinical knowledge, this book and its companion are edited and written by leading international authorities. Together they are an essential resource for neuroscientists and provide a foundation for the work of clinical neurorehabilitation professionals.

Die Alzheimer-Demenz gilt als die häufigste neurodegenerative Erkrankung des höheren Lebensalters. Die mit dieser Krankheit assoziierten neuromorphologischen Veränderungen führen zu vielfältigen klinischen, psychopathologischen sowie neuropsychologischen Störungen und lassen sich mit geeigneten Bild gebenden Verfahren in vivo darstellen. In der vorliegenden Arbeit werden die Zusammenhänge zwischen klinischen Beobachtungen und zerebralen Veränderungen mit der Magnetresonanztomographie (MRT) systematisch sowohl bei manifester Alzheimer-Demenz als auch bei leichter kognitiver Beeinträchtigung untersucht. Zusammenfassend erweitern die Ergebnisse einerseits unser Verständnis der Zusammenhänge zwischen zerebralen Veränderungen und Krankheitssymptomen und können andererseits klinisch zur Früh- und Differentialdiagnostik der Alzheimer-Demenz einschließlich ihrer präklinischen Stadien beitragen. Sie ermöglichen aber auch ein objektives Verlaufsmonitoring der Erkrankung. Diese Perspektiven dürften mit der Entwicklung neuer – hoffentlich auch kurativer – therapeutischer Strategien klinisch noch an Bedeutung gewinnen.

Completely updated including coverage of the Parkin gene, this second edition unveils advances in the genetics of Parkinson's Disease (PD). The author reviews the role of alpha synuclein in the genesis of PD and covers tau protein and related diseases, MPTP and drug induced PD, oxidative stress, mitochondrial dysfunction, and apoptosis. He explores pharmacological approaches to the treatment of PD such as the use of COMT inhibitors and dopamine agonist and advances in technology such as devices that provide additional treatment options including deep brain stimulation and transplantation. The book concludes with new chapters covering the differential diagnosis of PD and related disorders.

Das tiefe Tal überwinden! Depressionen gehören zu den häufigsten psychiatrischen Krankheitsbildern. Therapiemöglichkeiten gibt es viele, und meistens haben sie auch Erfolg. Was aber tun, wenn sich eine Depression als therapieresistent, extrem langanhaltend oder ständig wiederkehrend erweist? Einfach weiterprobieren – oder praktische Hilfe suchen? Die Neuauflage der Therapieresistenten Depressionen beantwortet Ihre Fragen: Was sind die Ursachen, und wie definiert man eine therapieresistente Depression? Welche weiteren pharmakologischen und nichtpharmakologischen Behandlungsmöglichkeiten gibt es? Wie sollte der Gesamtbehandlungsplan aussehen? Welche Zukunftsperspektiven eröffnen sich? Hier finden Sie praktische Anleitungen und Leitlinien für Ihren Therapieplan und profitieren von den neuesten Forschungsergebnissen eines internationalen Autorenteams. So entwickeln Sie die optimalen Behandlungsstrategien für Ihre Patienten!

Parkinson's Disease and Nonmotor Dysfunction fills a major gap in the current rapidly growing body of knowledge concerning Parkinson's disease. Drs. Pfeiffer and Bodis-Wollner have correctly perceived that many nonmotor features of Parkinson's disease are given insufficient attention in the medical literature. Unfortunately, they are often also given insufficient attention by the practicing neurologists who see these patients. As recently pointed out, there is clearly much more to Parkinson's disease than depletion of the nigrostriatal dopamine system (1). Parkinson's disease (not just m- tiple system atrophy) is a multisystem disorder, both pathologically and in its clinical manifestations. This is clearly true for the various motor system abnormalities, which are not fully corrected by dopamine replacement therapy strategies, but also for the nonmotor system abnormalities that are the subject of this volume. Although recently there has been increased awareness of the cognitive, psychiatric, and sleep disorders commonly associated with Parkinson's disease, many of their manifestations remain under-recognized and their importance in managing patients is underestimated. Even less attention is paid to the myriad of other nonmotor disturbances that plague these patients. For example, among the autonomic disorders, although orthostatic hypotension is well recognized, it is usually attributed to dopaminergic medications rather than to effects of the underlying disease. Urologic disorders are also very familiar in these patients, but may not be properly understood or well managed.

How does the brain represent number and make mathematical calculations? What underlies the development of numerical and mathematical abilities? What factors affect the learning of numerical concepts and skills? What are the biological bases of number knowledge? Do humans and other animals share similar numerical representations and processes? What underlies numerical and mathematical disabilities and disorders, and what is the prognosis for rehabilitation? These questions are the domain of mathematical cognition, the field of research concerned with the cognitive and neurological processes that underlie numerical and mathematical abilities. TheHandbook of Mathematical Cognition is a collection of 27 essays by leading researchers that provides a comprehensive review of this important research field.

The rising prevalence of dementia in the population continues to pose a serious public health challenge in both the developed and the developing world. Previous editions of Dementia have become acknowledged as a key'gold standard'work in this field, and have had a genuinely international approach. The third edition has been fully revised and upda

A comprehensive review of current tactics in the therapeutic management of Parkinson's disease, this volume offers summaries of salient research findings as well as contemporary attitudes and practical advice from field specialists. The well-timed Third Edition is expanded and topically reorganized to register trends and progress in anti-parkinsoni